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Abstract Title:

Short-Time Administration of Xanthone FromFruit Pericarp Attenuates the Hepatotoxicity and Renotoxicity of Type II Diabetes Mice.

Abstract Source:

J Am Coll Nutr. 2019 Dec 17:1-10. Epub 2019 Dec 17. PMID: 31846399

Abstract Author(s):

Naymul Karim, Md Atiar Rahman, Suksan Changlek, Jitbanjong Tangpong

Article Affiliation:

Naymul Karim

Abstract:

Our previous studies reported that xanthone can protect from hyperglycemia-induced diabetes mellitus (DM) via possessing antioxidant activity. An attempt has been made to evaluate the protective effect of xanthone against hepatotoxicity and renotoxicity of high-fat-diet and single-dose-streptozotocin-induced DM mice.In this research,antioxidant and antidiabetic assays were performed.oral glucose and maltose tolerance test, metabolic parameters, plasma biochemical markers, oxidative status, etc. were evaluated in experimental mice. In addition, liver/kidney tissue histology and kidney apoptosis were observed using hematoxylin and eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays, respectively.Xanthone exhibited potentantioxidant and antidiabetic activity. Xanthone treatments to diabetic mice significantly ( < 0.05) improved the biochemical and antioxidant parameters compared to that of the control group. Moreover, xanthone treatments also significantly (< 0.05) reformed the liver and kidney histological alterations as well as reduced the cellular apoptosis of kidney tissue.All findings together concluded that xanthone could be a dietary supplement for the patient with diabetic complications.

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