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Abstract Title:

Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats.

Abstract Source:

Dig Dis Sci. 2008 Jul;53(7):1837-41. Epub 2008 Apr 22. PMID: 18427990

Abstract Author(s):

E Southcott, K L Tooley, G S Howarth, G P Davidson, R N Butler

Article Affiliation:

Centre for Paediatric and Adolescent Gastroenterology, Women's and Children's Hospital, Children, Youth and Women's Health Service, 72 King William Road, North Adelaide, SA 5006, Australia.

Abstract:

Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow's milk yoghurt (CY; fermented with Lactobacillus johnsonii), MTX + sheep's milk yoghurt (SY; containing Lactobacillus bulgaricus and Streptococcus thermophilus), and saline. Treatment gavage occurred twice daily for 7 days pre-MTX and 5 days post-MTX. Intestinal permeability was assessed on days -7, -1, 2, and 5 of the trial. Intestinal sections were collected at sacrifice for histological and biochemical analyses. Histology revealed that rats receiving CY and SY did not have a significantly damaged duodenum compared to controls. However, an improved small intestinal barrier function was evident, determined by a decreased lactulose/mannitol ratio. Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis.

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Sayer Ji
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