Abstract Title:

Yucca gloriosa: a source of phenolic derivatives with strong antioxidant activity.

Abstract Source:

J Agric Food Chem. 2007 Aug 8;55(16):6636-42. Epub 2007 Jul 11. PMID: 17625876

Abstract Author(s):

Carla Bassarello, Giuseppe Bifulco, Paola Montoro, Alexandre Skhirtladze, Mariam Benidze, Ether Kemertelidze, Cosimo Pizza, Sonia Piacente

Abstract:

On the basis of the biological activities exhibited by the phenolic constituents of Yucca schidigera, the antioxidant activity of the methanol extract of Yucca gloriosa roots was evaluated in the TEAC assay. The strong activity exerted by this extract prompted investigation of its phenolic constituents, yielding three new phenolic derivatives, gloriosaols C, D, and E, along with gloriosaols A and B previously isolated from Y. gloriosa roots and yuccaols C-E isolated from Y. schidigera. ESIMS and NMR data of gloriosaols C-E closely resembled those reported for gloriosaols A and B, two diasteroisomers characterized by unusual spirostructures. Careful inspection of ROESY spectra revealed that gloriosaols C-E are diastereoisomers of gloriosaols A and B. A possible assignment of the relative configuration of gloriosaols C-E, derived according to an integrated NMR-quantum mechanical (QM) approach, which was already applied to the determination of the stereostructures of gloriosaols A and B, is also proposed. Gloriosaols A-E exhibited potent antioxidant activity measured by the TEAC assay, showing the potential use of Y. gloriosa as a source of antioxidant principles.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758)

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Sayer Ji
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