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Abstract Title:

The effect ofhydroalcoholic extract on memory and lung changes induced by rats that inhaled paraquat.

Abstract Source:

Nutr Neurosci. 2019 Oct 4:1-14. Epub 2019 Oct 4. PMID: 31583983

Abstract Author(s):

Mahrokh Heydari, Amin Mokhtari-Zaer, Fatemeh Amin, Arghavan Memarzia, Saeideh Saadat, Mahmoud Hosseini, Mohammad Hossein Boskabady

Article Affiliation:

Mahrokh Heydari

Abstract:

The effects of hydroalcoholic extract of() on memory changes, as well as lung injury due to inhaled paraqut (PQ) in rat, were examined.Control group of rat with saline aerosol administration, PQ groups with PQ aerosol (27 and 54 mg/m) administration, PQ groups treated with two doses of the extract (200 and 800 mg/kg/day) and dexamethasone (0.03 mg/kg/day) were studied. Shuttle box and Morris Water Maze (MWM) tests were carried out as well as oxidant, anti-oxidant markers, total and differential white blood cell (WBC) counts and cytokine levels in broncho-alveolar lavage (BALF).Inhaled PQ significantly increased the escape latency and travelled distance in MWM test, but the time spent in the target quadrant on the probe day was significantly reduced (<0.05 to p<0.001). The latency to enter the dark room at 3, 24, and 48 h after an electrical shock was reduced due to PQ (<0.05 to<0.001). Exposure to PQ significantly increased total WBC, neutrophil, eosinophil, lymphocyte, and monocyte counts, IL-10, interferon gama (INF-γ), nitrite (NO), and malondialdehyde (MDA) levels, but catalase (CAT), superoxide dismutase (SOD), and thiol levels were decreased (<0.05 to<0.00).and dexamethasone treatment significantly improved all behavioral as well as lung changes induced by inhaled PQ (<0.05 to<0.01).treatment improved learning and memory impairment as well as lung inflammation and oxidative stress induced by inhaled PQ.

Study Type : Animal Study

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