Article Publish Status: FREE
Abstract Title:

The Preventive Effects of Standardized Extract ofand Carvacrol on Acetaminophen-Induced Hepatotoxicity in Rat: -Carvacrol and Hepatotoxicity.

Abstract Source:

J Pharmacopuncture. 2018 Dec ;21(4):249-257. Epub 2018 Dec 31. PMID: 30652051

Abstract Author(s):

Reza Mohebbati, Maryam Paseban, Farimah Beheshti, Mohammad Soukhtanloo, Mohammad Naser Shafei, Hasan Rakhshandeh, Abolfazl Khajavi Rad

Article Affiliation:

Reza Mohebbati


Objectives: The hepatotoxicity induced by Acetaminophen (AAP) mostly mediated by effect on oxidative stress parameters. The(Z.M) is an herbal medicine with well-known antioxidant effect. The aim of this study is investigation of preventive effects of Z.M and Carvacrol (CAR) on AAP-induced hepatotoxicity in rats.

Methods: Rats were randomly divided into four groups including: 1) Control, 2) Acetaminophen (AAP), 3) and 4) CAR. The saline, Z.M (200 mg/kg) and CAR (20 mg/kg) were administrated orally for 6 days, after that AAP (600 mg/kg) was administrated in the 7day. Blood sampling was performed on the first and last days. Also, the liver tissue was removed for evaluation of Malondyaldehide (MDA), Thiol content, Superoxide dismutase (SOD) and Catalase (CAT). Total Protein (tPro), Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Alkaline Phosphatase (ALP) in liver tissue were evaluated. The changes (Δ) of enzymes activities were presented.

Results: TheΔ GOT, Δ GPT and Δ ALP in CAR group significantly decreased compared to AAP group (P<0.01 to P<0.001) andΔ GPT in Z.M group was significantly reduced in comparison with AAP group (P<0.05). Also, MDA, Thiol, SOD and CAT levels in treated groups were attenuated compared to AAP group (P<0.05 to P<0.001).

Conclusion: Z.M and CAR have a powerful hepatoprotective effect. CAR is more effective than Z.M. Based on the results. Z.M and CAR could be potent supplementary agents against hepatotoxicity of AAP in patients.

Study Type : Animal Study

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