Article Publish Status: FREE
Abstract Title:

Accelerative effect of topicalessential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis.

Abstract Source:

Pharm Biol. 2021 Dec ;59(1):1-10. PMID: 33378625

Abstract Author(s):

Mohammad Reza Farahpour, Sara Sheikh, Elham Kafshdooz, Ali Sonboli

Article Affiliation:

Mohammad Reza Farahpour


CONTEXT: Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection.

OBJECTIVE: This study evaluates the effects of an ointment prepared from ZME (ZMEO) on infected wounds.

MATERIALS AND METHODS: A full-thickness excisional skin wound was surgically created in each mouse and inoculated with 5 × 10suspension containingand. The BALB/c mice ( = 72) were divided into four groups: (1) negative control that received base ointment (NCG), (2) positive control that daily received Mupirocin(MG), (3) therapeutic ointment containing 2% ZMEO and (4) therapeutic ointment containing 4% ZMEO, for 21 days. Wound contraction, total bacterial count, histopathological parameters, antioxidant activity, qRT-PCR analysis for expression of IL-1β, TNF-α, VEGF, IGF-1, TGF-β, IL-10, and FGF-2 mRNA levels were assessed on days 3, 7, and 14 following the wounding.

RESULTS: Topical administration of ZMEO significantly decreased the total bacterial count and wound area and also expression of IL-1β and TNF-α compared to the control groups ( < 0.05) in all days. This could also increase significantly the expression of TGF-β, IL-10 IGF-1, FGF-2, and VEGF, and also angiogenesis, fibroblasts, fibrocytes, epithelialization ratio, and collagen deposition and improve antioxidant status compared to the control group ( < 0.05).

DISCUSSION AND CONCLUSION: ZMEO accelerated the healing process of infected wounds by shortening the inflammatory factors and increasing proliferative phase. Applying ZMEO only and/or in combination with chemical agents for the treatment of wound healing could be suggested.

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