n/a
Article Publish Status: FREE
Abstract Title:

Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats.

Abstract Source:

Avicenna J Phytomed. 2019 Nov-Dec;9(6):587-596. PMID: 31763217

Abstract Author(s):

Vahid Sheibani, Ali Mandegary, Elham Vazifekhahan, Zahra Kasbzade, Amir Asadi, Fariba Sharififar

Article Affiliation:

Vahid Sheibani

Abstract:

Objective: () has been proposed for memory enhancing in Persian traditional medicine; but to now, no study has been carried out in this field yet. The aim of this research was to study the plant effect on spatial memory in scopolamine-induced amnesia and investigateanticholinesterase effect of.

Material and Methods: Aerial parts of the plant were extracted with methanol and standardized on the basis of rutin content. Male rats received three doses ofextract (100, 200 and 400 mg/kg, intraperitoneal (ip) for 7 days) and 30 min after the latest dose, scopolamine (1 mg/kg) was administered to animals. Learning capacity and spatial memory were studied using morris water maze (MWM) and passive avoidance test (PAT) methods. Anticholinesterase activity was studied using Ellman's method. Physostigmine (0.3 mg/kg) and piracetam (200 mg/kg) were used as positive controls.

Results: All doses ofextract significantly decreased the distance and time spent to find the platform in MWM and increased the time latency in PAT test. In both MWM and PAT tests, the highest effect ofwas observed at 200 mg/kg which was in accordance with AChE inhibitory effect of the plant.

Conclusion: Our findings indicate thathas anti-amnesic effect and might improve memory deficit through anticholinesterase activity.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.