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Abstract Title:

The effects of Zataria multiflora Boiss. (Shirazi thyme) on nonalcoholic fatty liver disease and insulin resistance: A randomized double-blind placebo-controlled clinical trial.

Abstract Source:

Complement Ther Med. 2018 Dec ;41:118-123. Epub 2018 Sep 17. PMID: 30477827

Abstract Author(s):

Nasrindokht Zamani, Mesbah Shams, Majid Nimrouzi, Mohammad Mehdi Zarshenas, Amin Abolhasani Foroughi, Ebrahim Fallahzadeh Abarghooei, Mohammad Reza Fattahi

Article Affiliation:

Nasrindokht Zamani

Abstract:

OBJECTIVE: The aim of the study is to evaluate the effects of Zataria multiflora Boiss. (Shirazi thyme) (ZM) supplementation on nonalcoholic fatty liver disease (NAFLD) and related insulin resistance (IR).

DESIGN: In this randomized double-blind placebo-controlled clinical trial, 85 patients with NAFLD were administered either 700 mg ZM powder or placebo twice daily for 12 weeks. All patients were advised to follow the recommendations for diet modification.

RESULTS: ZM supplementation resulted in a significant reduction in serum insulin level (-2.72 ± 0.80 vs -0.67 ± 0.90, P0.030), insulin resistance (-0.80 ± 0.22 vs 0.06 ± 0.22, P0.023), systolic (-3.44 ± 1.05 vs 1.03 ± 0.98, P0.002) and diastolic (-2.33 ± 0.77 vs 0.26 ± 0.63, P0.009) blood pressure in patients with NAFLD in comparison with the placebo group. There was no significant difference between two groups regarding serum levels of alanine aminotransferase (ALT), high sensitive C-reactive protein (hs-CRP), Tumor necrosis factor-α (TNF-α), grade of fatty liver in ultrasonography, lipid profiles, and other outcomes.

CONCLUSION: ZM supplementation with daily dose of 1400 mg for 12 weeks improved insulin resistance in patients with NAFLD. Further studies with longer duration and larger sample size are recommended.

Study Type : Human Study

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