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Abstract Title:

Zebrafish embryos exposed to deltamethrin exhibited abnormalities in spite of induced expression of related genes ( you, you-too, momo and u-boot).

Abstract Source:

Toxicol Ind Health. 2018 Dec 5:748233718807046. Epub 2018 Dec 5. PMID: 30518298

Abstract Author(s):

Kuder Reshma Shabnam, Dharmapuri Gangappa, Gundala Harold Philip

Article Affiliation:

Kuder Reshma Shabnam

Abstract:

Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. These stages are selected as most of the important developmental aspects take place during this period. All four genes are known to play a vital role in development of notochord and somites. To understand the effect of DM on development, embryos of 4 hpf stage were exposed to two concentrations (100 and 200µg/L) of DM, and observations were made at 12, 24 and 48 hpf stages. Our earlier studies have shown phenotypic abnormalities such as notochord bending, tail deformation, yolk sac and pericardial edema, lightening of body and eye pigmentation and interfered in somite patterning, during these stagesof development. Understanding the relationship of phenotypic abnormalities with these four genes has been our primary objective. These four genes were analyzed by Reverse transcription (RT)-polymerase chain reaction and intensity of the bands has shown induction in their expression after exposure tothe toxicant. In spite of the expression of genes, it was noticed that DM caused abnormalities. It can be said from the results that translational pathway could have been affected.

Study Type : Animal Study

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