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Article Publish Status: FREE
Abstract Title:

Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha.

Abstract Source:

Sci Rep. 2018 Mar 6 ;8(1):4090. Epub 2018 Mar 6. PMID: 29511228

Abstract Author(s):

Salam Pradeep Singh, Khumukcham Nongalleima, Ningthoujam Indrajit Singh, Pradip Doley, Chingakham Brajakisor Singh, Thiyam Ramsing Singh, Dinabandhu Sahoo

Article Affiliation:

Salam Pradeep Singh

Abstract:

Zerumbone is a known anti-cancer herbal compound. However, the actual protein target is not fully understood or known. This investigation focus on the association of zerumbone in HCT116 colon cancer cell proliferation and its link with TNF-alpha. The study shows that with the increasing concentration of zerumbone, there was a reduction of HCT116 cells proliferation based on the cell line study and hence higher TNF-alpha inhibition based on the TNF-alpha assay. The study also emphasizes on the computational aspect by investigating the molecular docking analysis of zerumbone against TNF-alpha. The docked complex was further validated using molecular dynamics simulation studies. The docking analysis observed that alpha-beta unsaturated carbonyl scaffold is an important moiety for the anti-cancer activity of zerumbone. Furthermore, the DFT analysis also confirms the reactivity nature of zerumbone based on the frontier molecular orbital analysis.

Study Type : In Vitro Study

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