Zinc deficiency may be associated with low leptin levels. - GreenMedInfo Summary
The effects of zinc deficiency and testosterone supplementation on leptin levels in castrated rats and their relation with LH, FSH and testosterone.
Neuro Endocrinol Lett. 2005 Oct;26(5):548-54. PMID: 16264402
Selcuk University Meram Medical School Department of Urology, Konya, Turkey. firstname.lastname@example.org.
AIM: The aim of this study was to investigate how zinc-deficiency and testosterone supplementation, both in combination and individually, affect plasma LH, FSH and leptin levels in castrated rats. DESIGN: Group 1, Control Group. Group 2, Castration Group. Group 3, Testosterone Group. Group 4, Zinc-deficient Group. Group 5, Testosterone, Zinc-deficient Group. Group 6, Zinc-deficient, Castration Group. Group 7, Testosterone, Castration Group. Group 8, Zinc-deficient, Testosterone, Castration Group. MEASUREMENTS: Plasma zinc, leptin, LH, FSH, free and total testosterone levels were measured. RESULTS: Group 2 had the highest levels of leptin and LH, besides having the highest FSH levels together with Group 6 (p<0.01). Groups 5 and 8 had the lowest leptin levels (p<0.01). Leptin levels in Groups 4 and 7 were higher than those in Groups 5 and 8, but lower than those in all other groups (p<0.01). LH levels in Group 4 were not different than those in Groups 3, 5 and 8, but significantly lower than those in all other groups (p<0.01). Free and total testosterone levels were higher in Group 4 than in castration groups that were not supplemented testosterone, but were lower in the former than in all others (p<0.01). CONCLUSION: Plasma LH may be more effective than testosterone on plasma leptin and zinc can be an important mediator of the effect LH exercises on leptin.