L. fruit attenuates obesity-associated alterations:mechanisms.
Arch Physiol Biochem. 2019 Jun 1:1-8. Epub 2019 Jun 1. PMID: 31155964
CONTEXT: L., ZL is a Mediterranean plant and widely consumed for its beneficial medicinal properties.
OBJECTIVE: We assessed the effects of ZL fruit on diet-induced obesity.
MATERIALS AND METHODS: Male C57BL/6j mice were divided into three groups. Each group received either a standard diet or a high-fat diet, HFD (30% of palm oil, w/v) or a HFD-supplemented with ZL fruit powder (10%, w/w) for six weeks, followed by a six weeks period, in which animals were maintained on the HFD and ZL aqueous extract (1%, w/v). We measured plasma parameters and assessed the expression of key genes involved in energy metabolism and inflammation.
RESULTS: ZL fruit improved glycaemia, lipids concentrations and inflammation in obese mice.
DISCUSSION AND CONCLUSION: Our investigations showed that ZL fruit improved glucose tolerance, dyslipidaemia and fatty liver disease, but not the severity of HFD-induced obesity in mice.