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Abstract Title:

Flare-up of hand osteoarthritis caused by zoledronic acid infusion.

Abstract Source:

Osteoporos Int. 2009 Nov 21. Epub 2009 Nov 21. PMID: 19936866

Abstract Author(s):

G R Werner de Castro, F S Neves, S C de Magalhães Souza Fialho, I A Pereira, G Ribeiro, A F Zimmermann

Article Affiliation:

Rheumatology Unit, Hospital Governador Celso Ramos, Florianópolis, Brazil, castrogrwc@gmail.com.

Abstract:

Zoledronic acid is effective for osteoporosis at a single annual intravenous dose. It usually causes few adverse effects; the most common are related to acute phase reactions. We reported the case of a 64-year-old woman who presented flare-up of hand osteoarthritis after zoledronic acid infusions. Despite the fact that arthralgia is a common side effect of intravenous bisphosphonates, development of inflammatory signs in osteoarthritic joints is a rare event. We hypothesized that this side effect is caused by a release of cytokines secondary to activation of gamma-delta T lymphocytes.

Study Type : Human Study
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