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While technically a berry, pomegranate "fruit" may be nature's answer to turning the tide against the #1 cause of death in the industrialized world: heart disease. Let's start with what it tells us simply through experiencing it...
Pomegranate has a remarkable astringency, giving your mouth and gums that dry, puckering mouth feel. This cleansing sensation is technically caused, as with all astringents, by shrinking and disinfecting your mucous membranes.
Anyone who drinks pomegranate juice, or is lucky enough to eat one fresh, can understand why it is so effective at cleansing the circulatory system. Nature certainly planted enough poetic visual clues there for us: its juice looks like blood, and it does resemble a multi-chambered heart, at least when you consider its appearance in comparison to most other fruits.
But sometimes the obvious (in appearance and effect) is not compelling enough - certainly not for the hyper-rational, "evidence-based" folks in positions of medical and regulatory power today - so we have science to lend additional support and credibility, and perhaps even keep some of us from being fined or going to jail for stating the obvious, e.g. "This juice may be beneficial to your health."
Indeed, your mouth and your arteries are lined with the same cell type: epithelial cells. Together, they make up the epithelium, one of four basic tissue types within animals, along with connective tissue, muscle tissue and nervous tissue, and which comprises the interior walls of the entire circulatory system. So, when you feel that amazing cleansing effect in your mouth, this is in fact akin to what your circulatory system - and the epithelium/endothelium lining the inside of your veins and arteries - "feels" as well. How do we know this for sure?
A remarkable study, published in the journal Clinical Nutrition, took 10 patients with atherosclerosis and measured their carotid arteries before and after one year of supplementing their diet with pomegranate juice. After one year, the plaque clogging their carotid arteries was reduced by up to 30%, while the control group's blockages increased by 9% - effectively reversing the disease process by up to 39% within one year. Additional "side benefits" included a 130% increase in their antioxidant status, with LDL susceptibility to oxidation (it is far more important to maintain the quality of the LDL, i.e. keep it from getting damaged, than to nit-pick about the "right number") being reduced 59%. Finally, systolic blood pressure was reduced 21% within the first year. Wow, right? But it only gets better...
Pomegranate actually has been studied to possess therapeutic properties in over 80 diseases or disease symptoms. You can view the entire spectrum of studies on our ("our" meaning yours too, as we are open access) Pomegranate Research Page.
[In his upcoming book REGENERATE: Unlocking Your Body's Radical Resilience through the New Biology (pre-order here: https://amzn.to/2QUEFKb), Sayer documents the incredible new research showing you can reverse premature aging and chronic disease through dietary and lifestyle modifications. This clip is from his upcoming free masterclass Regenerate Yourself (sign up here: https://tinyurl.com/regenyourself). Download a free chapter of REGENERATE here: https://www.tinyurl.com/sayeregen Bon Appétit! Enjoy!]
Here are some additional highlights for cardiovascular health
- High Blood Pressure (Hypertension): One of the identified mechanisms behind pomegranate's blood-pressuring lowering properties is its ability to inhibit Angiotensin-Converting Enzyme, at least in the diabetic rat model.  But obviously, reversing the plaque build-up in the arteries is one way to disburden the heart, as well. Another is its ability to increase nitric oxide production in the artery (eNOS), which results in improving its ability to dilate - effectively, reversing endothelial dysfunction.
- Fighting Infection: While it is commonly overlooked, cardiovascular disease, and more particularly atherosclerosis, is connected to infection. Dentists know this, which is why they often prescribe antibiotics following dental work which releases bacteria into systemic circulation. Plaque in the arteries can also harbor viral pathogens. Pomegranate happens to have potent antiviral and antibacterial properties relevant to cardiovascular disease initiation and progression. It has been studied to combat the following infectious organisms:
- Avian Influenza
- Escherichia Coli
- Hepatitis B
- Influenza A
- Staphylococcus auerus
- Vaccinia virus
- Vibrio (Cholera) virus
[for first-hand citations visit our pomegranate page]
- Reduces Oxidative Stress: Pomegranate has potent antioxidant properties, which reduces the likelihood that LDL will oxidize, becoming the atherogenic/cardiotoxic form known as ox-LDL, which can injure the lining of the arteries and deposit there as plaque. These antioxidant properties have also been identified to have potential anti-platelet implications, potentially reducing the risk for an obstructive clot.
Pomegranate was upheld as a sacred fruit in many cultural traditions the world over. Whether Christian, Arab, Jew, Buddhist, or Hindu, pomegranate was perceived as a symbol and source of fertility and/or regeneration.
It is interesting to me that it is not religion, or any other cultural institution or artifact (except perhaps music), but a FRUIT, which binds us so closely together in the near-universal appreciation for what God/Nature provides as both a source of nourishment and a medicine of quite possibly unparalleled therapeutic properties for heart health.
For additional research on Unclogging Your Arteries, visit our research page on the topic which includes 129 substances of interest.
 Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc Res. 2007 Jan 15;73(2):414-23. Epub 2006 Sep 1. PMID: 17014835
 Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr. 2000 May ;71(5):1062-76. PMID: 10799367