Results for Shikonin

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Bladder Cancer : CK(521) : AC(176)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450), Apoptotic : CK(5217) : AC(3846), Chemosensitizer : CK(772) : AC(577)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(137) : AC(103), Dose Response : CK(1519) : AC(574), Shikonin

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.

Article Published Date : Apr 10, 2017
Study Type : Human In Vitro
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Glioblastoma : CK(398) : AC(193)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Antiproliferative : CK(4773) : AC(3450), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(551) : AC(315), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(543) : AC(337)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(65) : AC(52), Chemotherapeutic Synergy: Temozolomide : CK(5) : AC(4), Glioblastoma, Shikonin

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Liver Injury: Ischemia/reperfusion : CK(19) : AC(10)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Autophagy Inhibitors : CK(26) : AC(13), Hepatoprotective : CK(3182) : AC(1418)
Additional Keywords : Anti-Apoptotic, Autophagy Inhibitors : CK(5) : AC(4), Hepatoprotective, Liver Injury: Ischemia/reperfusion, Shikonin

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Diabetic Retinopathy : CK(60) : AC(23)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Anti-Inflammatory Agents : CK(12461) : AC(4729), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

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