Results for Shikonin

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Bladder Cancer : CK(632) : AC(247)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032), Apoptotic : CK(6986) : AC(5304), Chemosensitizer : CK(1124) : AC(854)
Additional Keywords : Antiproliferative : CK(65) : AC(52), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(290) : AC(232), Dose Response : CK(1712) : AC(683), Shikonin

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.

Article Published Date : Apr 10, 2017
Study Type : Human In Vitro
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Glioblastoma : CK(545) : AC(272)
Pharmacological Actions : Anti-metastatic : CK(1972) : AC(1481), Antiproliferative : CK(6801) : AC(5032), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(727) : AC(442), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(786) : AC(505)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(65) : AC(52), Chemotherapeutic Synergy: Temozolomide : CK(48) : AC(35), Glioblastoma, Shikonin

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Liver Injury: Ischemia/reperfusion : CK(95) : AC(52)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Autophagy Inhibitors : CK(175) : AC(115), Hepatoprotective : CK(5098) : AC(2264)
Additional Keywords : Anti-Apoptotic, Autophagy Inhibitors : CK(5) : AC(4), Hepatoprotective, Liver Injury: Ischemia/reperfusion, Shikonin

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Diabetic Retinopathy : CK(290) : AC(121)
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672), Anti-Inflammatory Agents : CK(20859) : AC(8334), Cyclooxygenase 2 Inhibitors : CK(1589) : AC(926)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

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