Neurotoxic

Name	AC	CK
Statin Drugs	40	191
Thimerosal	32	187
Gluten	18	141
Gliadin	10	100
Simvastatin	21	82
Fluoride	10	80
Wheat	10	72
Oseltamivir (trade name Tamiflu)	7	59
Mercury	11	56
Bisphenol A	22	54
Lovastatin	15	52
Lead	7	51
Arsenic	4	50
Aluminum	21	45
Glyphosate	21	42
Tamoxifen	3	40
Pesticides	9	38
Aluminum Hydroxide	5	25
Sodium Fluoride	9	24
Donepezil (trade name Aricept)	3	23
Pravastatin	3	23
Antipsychotic Drugs	2	22
Quetiapine	2	22
Rivastigmine	2	21
Amoxapine	1	20
Buproprione	1	20
Chlorprothiexene	1	20
Clozapine	1	20
Dental Amalgams	1	20
Escitaloprame	1	20
Fenofibrates	2	20
Maprotilene	1	20
Risperidone	1	20
Tobacco	2	20
Trimipramine	1	20
Aspartame	10	18
Atorvastatin	9	18
Monosodium Glutamate (MSG)	4	16
Tricresyl phosphates (TCPs)	5	15
Cholesterol Lowering Drugs	3	14
Organophosphates	2	12
Triclosan	2	12
Agricultural Chemicals	1	10
Aspirin	5	10
BisGMA-based dental products	1	10
Bupropion	1	10
Butyrophilin	1	10
Casein	1	10
Chlamydia Pneumoniae	1	10
Cow Milk	1	10
Energy Drinks	1	10
Industrial Copper (inorganic)	1	10
Industrial Iron	1	10
Iodine: Excess	1	10
Nicotine	1	10
Organochlorine pesticides	1	10
Parabens	1	10
Pepper Spray	1	10
Perfluorinated compounds	1	10
Perfluorooctane sulfonate (PFOS)	1	10
Polycyclic aromatic hydrocarbon: coal-fired power plant associated	1	10
Streptococcal M Protein	1	10
Tobacco Smoke: Passive	1	10
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	4	8
Herbicides	2	7
Paraquat	3	7
Infliximab	2	6
Brevetoxin	3	5
Chlorpyrifos	3	5
Red tide	3	5
Acetaminophen	2	4
Aluminum Chloride	2	4
Cadmium	2	4
Cipro	2	4
Flame Retardants	2	4
Paracetamol	2	4
Roundup (herbicide)	2	4
Sucralose (aka Splenda)	2	4
Sucrose	2	4
Antibiotics	1	3
Bisphenol S	2	3
Fusidic acid	1	3
Lamivudine	1	3
Rosuvastatin	1	3
Synthetic Cannabinoids	1	3
Acesulfame potassium	1	2
Aluminum oxide	1	2
Aromatase Inhibitor Drugs	1	2
Artificial Sweeteners	1	2
Cyclophosphamide	1	2
Deltamethrin	1	2
Dichlorvos	1	2
Doxorubicin	1	2
Endocrine Disrupting Chemicals (EDCs)	1	2
Fluoxetine (trade name Prozac)	1	2
Formaldehyde	1	2
Fructose	1	2
Glyphosate formulations	1	2
Memantine	1	2
Nanoparticles	1	2
Parathion	1	2
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	2
Uranium: Depleted	1	2
Vaccine Adjuvants	1	2
Zinc Chloride	1	2
Alcohol Consumption	1	1
Benzo(a)pyrene	1	1
Brilliant Blue FCF	1	1
Chemotherapy	1	1
Cholinesterase Inhibitor Drugs	1	1
Dimethoate	1	1
Epstein-Barr Virus	1	1
Ethanol	1	1
Fluoroquinolone Antibiotic	1	1
Galantamine	1	1
Hormone Replacement Therapy	1	1
L-glutamic Acid	1	1
Mevastatin	1	1
Quinoline Yellow	1	1
Tylenol	1	1
Zinc Oxide	1	1
Zineb	1	1

Name	AC	CK
Statin-Induced Pathologies	44	187
Childhood Cognitive Disorders	10	140
Cognitive Decline/Dysfunction	15	124
Neurodevelopmental Disorders	15	114
Intelligence Quotient (IQ): Low/Impaired	8	110
Childhood Chemical Exposures	7	90
Celiac Disease	10	84
Gluten Sensitivity	9	83
Peripheral Neuropathies	10	79
Drug-Induced Toxicity	10	73
Autism Spectrum Disorders	10	68
Prenatal Nutrition: Learning/Intelligence of Offspring	7	68
Multiple Sclerosis	10	61
Tic Disorders	3	60
Autism	7	55
Neurodegenerative Diseases	22	54
Prenatal Chemical Exposures	13	54
Memory Disorders: Drug-Induced	4	50
Neuropathies	11	50
Psychiatric Disorders	7	50
Seizures	3	50
Mercury Poisoning	7	48
Alzheimer's Disease	11	47
Learning disorders	5	45
Amyotrophic Lateral Sclerosis	5	43
Vaccine-induced Toxicity	6	39
Neurotoxicity	18	37
Memory Disorders	9	36
Depression	4	32
Bisphenol Toxicity	14	30
Cerebellar Ataxia	3	30
Fluoride Toxicity	6	30
Schizophrenia	3	30
Pesticide Toxicity	12	28
Aluminum Toxicity	17	27
Brain Inflammation	5	26
Glyphosate Toxicity	13	25
Infant Neurological Development	4	24
Headache	3	23
Memory Loss	3	23
Migraine Disorders	3	23
Attention Deficit Hyperactivity Disorder	3	21
Aggression	2	20
Ataxia: Cerebellar	2	20
Attention Deficit Disorder	1	20
Brain Damage	8	20
Fluorosis	1	20
Infant Infections	1	20
Infantile Spasms	1	20
Influenza	1	20
Lead Poisoning	2	20
Lyell syndrome	1	20
Meningitis: Drug-Induced	1	20
Mental Retardation	1	20
Metabolic Diseases	1	20
Pneumonia: Drug-Induced	1	20
Smoking	2	20
Speech Disorders	1	20
Demyelinating Diseases	6	19
Oxidative Stress	9	18
Polyneuropathies	3	16
Aerotoxic Syndrome	5	15
Pregnancy: Psychological and Physical Distress.	3	14
Attention Deficit Disorder with Hyperactivity	3	13
Autoimmune Diseases	3	13
Brain: Oxidative Stress	7	13
Dementia	4	13
Psychological Well-Being	2	13
Brain: Microglial Activation	3	12
Chemotherapy-Induced Toxicity	2	12
Fetal Origin of Adult Disease	2	12
Gulf War Syndrome	2	12
Inflammation	2	12
Parkinson's Disease	8	12
Epilepsy	2	11
Suicidal Behavior	2	11
Anxiety Disorders	1	10
Arsenic Poisoning	1	10
Ataxia: Dominant	1	10
Ataxia: Sporadic	1	10
C-Reactive Protein	1	10
CNS White Matter Abnormalities	1	10
Carpal Tunnel Syndrome	1	10
Casein Intolerance	1	10
Cerebral Calcifications	1	10
Childhood Infections	1	10
Children: Impaired Growth	1	10
Coal-Fired Power Plant Associated Toxicity	1	10
Copper Toxicity	1	10
Cornea Damage	1	10
Developmental Disorder: Children	1	10
Epilepsy: With Cerebral Calcifications	1	10
Food Allergies	1	10
Gluten Ataxia	1	10
Headache: Migraine	1	10
Hearing Loss	5	10
Heavy Metal Toxicity	1	10
Hyperexcitable brain and refractory coeliac disease	1	10
Hypertension	1	10
Impotence	1	10
Impulse Control Disorders	1	10
Iron Poisoning	1	10
Migraines	1	10
Myofascial Pain Dysfunction Syndrome: Temporomandibular Joint	1	10
Neuropsychological Dysfunction: Psychomotor Speed	1	10
Nicotine/Tobacco Toxicity	1	10
Parkinsonian Disorders	5	10
Pesticide-Induced Toxicity: Organophosphates	1	10
Post-Traumatic Stress Disorders (PTSD)	1	10
Psychological Distress	1	10
Psychoses	1	10
Sensory Neuropathies	1	10
Sleep Disorders	1	10
Spinocerebellar Ataxia Type 2	1	10
Suicidal Ideation	1	10
TSH: Elevated	1	10
Lipid Peroxidation	5	9
Bisphenol-A Toxicity	4	8
Parkinsonism	4	8
Tinnitus	4	7
Birth Defects	2	6
Brain Injury: Hippocampal Damage	3	6
Encephalopathies	2	6
Mitochondrial Diseases	2	6
Abortion: Spontaneous	1	5
Acetaminophen (Tylenol) Toxicity	3	5
Ataxia	3	5
Diabetes Mellitus: Type 2	2	5
Excitotoxicity	3	5
Herbicide Toxicity	1	5
Red Tide Associated Toxicity	3	5
Delirium: Drug-Induced	2	4
Dopamine Levels: Low	2	4
Drug-Induced Nutrient Depletion: Statin Drugs	2	4
Hypothyroidism	2	4
Insulin Resistance	2	4
Neurologic Disorders	4	4
Substantia Nigra: Damage	2	4
Tremor	2	4
Aging	2	3
Blood-Brain-Barrier Disorders	2	3
Bulbar palsy	1	3
Cerebral Hypoperfusion	1	3
Encephalomyelitis	1	3
Guillain-Barre Syndrome	1	3
Hepatitis B	1	3
Melas Syndrome	1	3
Meningitis: Aseptic	1	3
Mood Disorders	1	3
Obesity	2	3
Rhabdomyolysis	1	3
Schizophrenic Disorders	1	3
Uveitis	1	3
Amyloidosis	1	2
Anxiety	1	2
Bee Colony Collapse	1	2
Brain Cancer	1	2
Brain: Vascular Congestion	1	2
Breast Cancer	1	2
Breast Cancer: Prevention	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
DNA damage	2	2
Diabetes: Cognitive Dysfunction	1	2
Formaldehyde Toxicity	1	2
Fructose-Induced Toxicity	1	2
HPA Axis Dysregulation	1	2
Infant Chemical Exposures	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Liver Damage: Drug-Induced	1	2
MSG Toxicity	1	2
Neurodegeneration: Dentate Gyrus	1	2
Neuromuscular Diseases	1	2
Obesity: Hypothalamic	1	2
Overweight	1	2
Testicular Diseases	1	2
Uranium Poisoning	1	2
Alcohol Toxicity	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Asthma	1	1
Ataxia: Idiopathic	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bronchitis	1	1
Cadmium Poisoning	1	1
Chemically-Induced Liver Damage	1	1
Chemotherapy-Induced Neurotoxicity	1	1
Cochlear Neuronal Damage	1	1
Depression	1	1
Dizziness	1	1
Endocannabinoid Disorders	1	1
Epstein-Barr Virus Infections	1	1
Gastrointestinal Complaints	1	1
Hallucinations	1	1
Hearing Disorders	1	1
Infertility	1	1
Macrophagic myofasciitis	1	1
Neuromyotoxicity	1	1
Neurotoxic Shellfish Poisoning	1	1
Parasuicide	1	1
Reye Syndrome	1	1
Skeletal Muscle Changes: Ultrastructural Changes	1	1
Stroke	1	1

Additional Keywords : Drug: Tamoxifen

Problem Substances : Tamoxifen

Adverse Pharmacological Actions : Neurotoxic

[+]

The WHO reports 71,471 seizures from a variety of neuroactive drugs between 1968-2006.Mar 01, 2010

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Pubmed Data : Seizure. 2010 Mar;19(2):69-73. Epub 2009 Dec 24. PMID: 20036167

Article Published Date : Mar 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Seizures

Problem Substances : Amoxapine, Buproprione , Chlorprothiexene , Clozapine, Donepezil (trade name Aricept), Escitaloprame, Maprotilene , Quetiapine, Rivastigmine, Trimipramine

Adverse Pharmacological Actions : Neurotoxic

[+]

There is good evidence to support the existence of both metabolic and neurological adverse effects in children treated with second-generation antipsychotics.Jul 31, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Saf. 2011 Aug 1 ;34(8):651-68. PMID: 21751826

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2019 Sep 1 ;378:114608. Epub 2019 Jun 5. PMID: 31173788

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Fluoride Toxicity

Problem Substances : Sodium Fluoride

Adverse Pharmacological Actions : Neurotoxic

[+]

Cognitive impairment and associated loss in brain white microstructure in aircrew members exposed to engine oil fumes.May 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Imaging Behav. 2016 Jun ;10(2):437-44. PMID: 26063438

Article Published Date : May 31, 2016

Study Type : Human Study

Additional Links

Diseases : Aerotoxic Syndrome, Brain Damage, Depression

Anti Therapeutic Actions : Air Travel

Problem Substances : Tricresyl phosphates (TCPs)

Adverse Pharmacological Actions : Neurotoxic

[+]

Decreased brain volume in adults with childhood lead exposure.May 26, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Environ Pollut. 2014 Apr ;187:130-5. Epub 2014 Jan 28. PMID: 24486466

Click here to read the entire abstract

Pubmed Data : Biol Psychiatry. 2010 Jul 1;68(1):100-4. Epub 2010 May 14. PMID: 20471632

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Diseases : Celiac Disease, Gluten Sensitivity, Psychoses, Schizophrenia

Problem Substances : Gliadin, Gluten, Wheat

Adverse Pharmacological Actions : Neurotoxic

[+]

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.Sep 01, 2011

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Pubmed Data : J Psychosoc Oncol. 2011 Sep-Oct;29(5):499-514. PMID: 21882931

Article Published Date : Sep 01, 2011

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity, Memory Disorders: Drug-Induced, Memory Loss

Anti Therapeutic Actions : Chemotherapy

Problem Substances : Tamoxifen

Adverse Pharmacological Actions : Neurotoxic

[+]

Mercury and elevated testosterone in autistic children may work synergistically and more studies should be conducted to understand the relationship.Jan 01, 2005

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Pubmed Data : Med Hypotheses. 2005 ;64(5):946-54. PMID: 15780490

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Testosterone

Diseases : Autism, Autism Spectrum Disorders

Additional Keywords : Heavy Metals and Autism, Vaccine Research

Problem Substances : Mercury

Adverse Pharmacological Actions : Neurotoxic

[+]

Mercury exposure from thimerosal containing childhood vaccines raised the subsequent risk of diagnosis of emotional disturbances.Jan 18, 2017

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Pubmed Data : Brain Inj. 2017 Jan 19:1-7. Epub 2017 Jan 19. PMID: 28102704

Psychiatric adverse reactions associated with cholesterol-lowering drugs have been reported. Jan 01, 2007

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Pubmed Data : Drug Saf. 2007 ;30(3):195-201. PMID: 17343428

Click here to read the entire abstract

Pubmed Data : Alzheimer Dis Assoc Disord. 2010 Jul-Sep;24(3):220-6. PMID: 20473136

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Med Med Res. 2014 Apr 16 ;4(8):1641-1662. PMID: 24839595

Article Published Date : Apr 16, 2014

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction

Additional Keywords : EMF

Anti Therapeutic Actions : 5G Millimeter Wave Radiation, Electromagnetic Fields, Electromagnetic Radiation, Microwave Radiation, Mobile Phone Radiation

Adverse Pharmacological Actions : Neurotoxic

[+]

The results suggest that aluminum-induced CRP may in part contribute to a pathophysiological state associated with a chronic systemic inflammation of the human vasculature.Jul 31, 2015

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Pubmed Data : J Inorg Biochem. 2015 Aug 1. Epub 2015 Aug 1. PMID: 26265215

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Interdiscip Toxicol. 2015 Jun ;8(2):68-76. PMID: 27486363

Article Published Date : Jun 01, 2015

Study Type : Human Study

Additional Links

Diseases : Tic Disorders

Additional Keywords : Vaccine Research

Anti Therapeutic Actions : Vaccination: All, Vaccination: Hepatitis B

Problem Substances : Mercury, Thimerosal

Adverse Pharmacological Actions : Neurotoxic

[+]

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2006 Jul ;92(1):246-53. Epub 2006 Apr 19. PMID: 16624850

Article Published Date : Jul 01, 2006

Study Type : Human In Vitro

Additional Links

Additional Keywords : Vaccine Research

Problem Substances : Mercury, Thimerosal

Adverse Pharmacological Actions : Apoptotic, Neurotoxic

[+]

This study reveals a similar activity of both ethylmercury and methylmercury. An ethylmercury-glutathione adduct was also identified, suggesting ethylmercury may impair glutathione activity.Apr 01, 2014

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Pubmed Data : J Trace Elem Med Biol. 2014 Apr ;28(2):125-30. Epub 2014 Feb 9. PMID: 24613139

[+]

Atorvastatin-induced polyneuropathy has been reported. Nov 04, 2003

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Pubmed Data : Ann Intern Med. 2003 Nov 4 ;139(9):792-3. PMID: 14597471

Measles vaccine and glyphosate-induced parkinsonism has been reported. Jun 01, 2003

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Pubmed Data : Arq Neuropsiquiatr. 2003 Jun ;61(2B):381-6. Epub 2003 Jul 28. PMID: 12894271

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Pubmed Data : Clin Rheumatol. 2007 Feb;26(2):258-60. Epub 2006 Jul 6. PMID: 16683176

Article Published Date : Feb 01, 2007

Study Type : Human: Case Report

Additional Links

Diseases : Peripheral Neuropathies

Problem Substances : Infliximab

Adverse Pharmacological Actions : Neurotoxic

[+]

Peripheral neuropathy induced by lipid-lowering therapy has been reported. Jul 01, 1998

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Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pak J Biol Sci. 2014 Sep ;17(9):1079-82. PMID: 26031030

Article Published Date : Aug 31, 2014

Article Published Date : Oct 22, 2015

Citalopram induced depressive-like behaviour in the offspring of control mothers in this rat study. Jan 31, 2016

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Pubmed Data : Eur J Neurosci. 2016 Feb ;43(4):590-600. Epub 2016 Jan 13. PMID: 26669896

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Depression

Additional Keywords : Transgenerational Epigenetic Modification

Anti Therapeutic Actions : Prenatal Stress

Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)

Adverse Pharmacological Actions : Neurotoxic

[+]

Curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.May 11, 2015

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Pubmed Data : Mol Neurobiol. 2015 May 12. Epub 2015 May 12. PMID: 25963729

Article Published Date : May 11, 2015

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Pubmed Data : Brain Res Bull. 2018 Sep ;142:297-303. Epub 2018 Aug 15. PMID: 30118749

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Parkinsonian Disorders, Pesticide Toxicity

Problem Substances : Deltamethrin, Pesticides

Adverse Pharmacological Actions : Neurotoxic

[+]

Differential microRNA expression in the prefrontal cortex of mouse offspring induced by glyphosate exposure during pregnancy and lactation.Feb 28, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2018 Mar ;15(3):2457-2467. Epub 2017 Dec 21. PMID: 29467848

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Diseases : Glyphosate Toxicity, Prenatal Chemical Exposures

Problem Substances : Glyphosate

Adverse Pharmacological Actions : Neurotoxic

[+]

Donepezil markedly potentiates memantine neurotoxicity.Feb 01, 2008

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Pubmed Data : Neurobiol Aging. 2008 Feb ;29(2):153-67. Epub 2006 Nov 16. PMID: 17112636

Article Published Date : Feb 01, 2008

Study Type : Animal Study

Additional Links

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Apoptotic

Additional Keywords : Drug Synergy

Problem Substances : Donepezil (trade name Aricept), Memantine

Adverse Pharmacological Actions : Neurotoxic

[+]

Early developmental bisphenol-A exposure sex-independently impairs spatial memory.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 ;6:32492. Epub 2016 Aug 31. PMID: 27578147

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pathophysiology. 2015 Jun ;22(2):105-15. Epub 2015 Apr 2. PMID: 25863844

Article Published Date : May 31, 2015

Click here to read the entire abstract

Pubmed Data : Brain Res. 2018 Jul 18. Epub 2018 Jul 18. PMID: 30030983

Article Published Date : Jul 17, 2018

Study Type : Animal Study

Additional Links

Anti Therapeutic Actions : Mobile Phone Radiation

Adverse Pharmacological Actions : Neurotoxic

[+]

exposure to thimerosal during early postnatal life produces lasting alterations in the densities of brain opioid receptors along with other neuropathological changes, which may disturb brain development.Oct 31, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neurochem Res. 2010 Nov ;35(11):1840-7. Epub 2010 Aug 28. PMID: 20803069

Article Published Date : Oct 31, 2010

Study Type : Animal Study

Additional Links

Anti Therapeutic Actions : Vaccination: All, Vaccination: Influenza

Problem Substances : Thimerosal

Adverse Pharmacological Actions : Neurotoxic

[+]

Fisetin may slow or prevent neurodegneration and can be utilised as neuroprotective agent against Alzheimer's and Parkinson's disease.Aug 07, 2015

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Pubmed Data : J Nutr Biochem. 2015 Aug 8. Epub 2015 Aug 8. PMID: 26411262

Article Published Date : Aug 07, 2015

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Aluminum Toxicity , Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Problem Substances : Aluminum Chloride

Adverse Pharmacological Actions : Neurotoxic

[+]

Fluoride levels in the 100-200 ppm range results in neurotoxicity in rats.Jul 24, 2010

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Pubmed Data : Biol Trace Elem Res. 2010 Jul 24. Epub 2010 Jul 24. PMID: 20658207

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Pubmed Data : Environ Toxicol Pharmacol. 2016 Jan 4 ;42:45-54. Epub 2016 Jan 4. PMID: 26773362

Article Published Date : Jan 03, 2016

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Pubmed Data : Food Chem Toxicol. 2017 Aug ;106(Pt A):223-231. Epub 2017 May 28. PMID: 28564613

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Problem Substances : Flame Retardants

Adverse Pharmacological Actions : Neurotoxic

[+]

High fluoride exposure has multigenerational and cumulative adverse effects on thyroid status, brain health and learning memory in rats. Jul 14, 2011

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Pubmed Data : Biol Trace Elem Res. 2011 Jul 14. Epub 2011 Jul 14. PMID: 21755305

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Matern Fetal Neonatal Med. 2014 Dec ;27(18):1915-21. Epub 2014 Apr 9. PMID: 24580725

Article Published Date : Dec 01, 2014

Study Type : Animal Study

Additional Links

Substances : Glutathione, Selenium, Vitamin A, Vitamin E

Diseases : Brain: Oxidative Stress, Mobile Phone-Induced Oxidative Stress, Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents

Additional Keywords : electromagnetic fields, electromagnetic frequencies, Electromagnetic Hypersensitivity, electromagnetic radiation, EMF, Pregnancy And Fetal Growth

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz, Mobile Phone Radiation

Problem Substances : Cell Phone Exposure

Adverse Pharmacological Actions : Neurotoxic, Oxidant

[+]

Long term exposure to cell phone frequencies induces apoptosis, mitochondrial oxidative stress and TRPV1 channel activation in the hippocampus.Jan 12, 2018

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Pubmed Data : Metab Brain Dis. 2018 Jan 13. Epub 2018 Jan 13. PMID: 29332300

Article Published Date : Jan 12, 2018

Study Type : Animal Study

Additional Links

Anti Therapeutic Actions : Mobile Phone Radiation

Adverse Pharmacological Actions : Neurotoxic

[+]

Long-term 1.8 GHZ RF-EMF induces memory impairments in rats that persist 2 weeks after radiation.Mar 01, 2013

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Pubmed Data : Electromagn Biol Med. 2013 Mar ;32(1):95-120. Epub 2013 Jan 15. PMID: 23320614

Article Published Date : Mar 01, 2013

Study Type : Animal Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Memory Disorders

Additional Keywords : Brain Function, Cell Phones, electromagnetic fields, electromagnetic frequencies, electromagnetic radiation, EMF, Radio Frequency Electromagnetic Radiation Exposure

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation, Electromagnetic Radiation: 1.8 GHz, Microwave Radiation, Mobile Phone Radiation

Problem Substances : Cell Phone Exposure

Adverse Pharmacological Actions : Neurotoxic

[+]

[+]

Long-term, excessive exposure to mobile phone electromagnetic fields leads to changes in Alzheimer's-related miRNA expression in the brain.Apr 01, 2015

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Pubmed Data : Int J Radiat Biol. 2015 Apr ;91(4):306-11. Epub 2015 Jan 27. PMID: 25529971

Article Published Date : Apr 01, 2015

Study Type : Animal Study

Additional Links

Additional Keywords : electromagnetic fields, electromagnetic frequencies, Electromagnetic Hypersensitivity, electromagnetic radiation, EMF

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation, Mobile Phone Radiation

Problem Substances : Cell Phone Exposure

Adverse Pharmacological Actions : Neurotoxic

[+]

Low cytochrome C oxidase is associated with Alzheimer's disease. This in vivo animal study indicates that certain heavy metals may induce oxidative stress and downregulate cytochrome C oxidase activity.Mar 01, 2011

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Pubmed Data : J Mol Neurosci. 2011 Mar ;43(3):284-9. Epub 2010 Aug 20. PMID: 20725867

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Pubmed Data : Nanoscale. 2015 Sep 21 ;7(37):15225-37. PMID: 26315713

Article Published Date : Sep 20, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Neurodegenerative Diseases

Additional Keywords : Risk Factors

Problem Substances : Aluminum oxide

Adverse Pharmacological Actions : Neurotoxic

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Nanoalumina stimulates mitochondrial dysfunction, leading to overactive autophagic degradation and results in apoptosis. This was confirmed by upregulation of apoptotic genes in the brains of nanoalumina-treated mice.Feb 01, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nanomedicine. 2013 Feb ;9(2):212-21. Epub 2012 Jun 9. PMID: 22687898

Article Published Date : Feb 01, 2013

Study Type : Animal Study

Additional Links

Diseases : Mitochondrial Dysfunction , Stroke, Stroke: Ischemic

Additional Keywords : Vaccine Research

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Aluminum, Aluminum oxide, Nanoparticles, Vaccine Adjuvants

Adverse Pharmacological Actions : Apoptotic, Blood Brain Barrier Injury, Inflammatory, Neurotoxic, Oxidant

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Neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEA may protect against mercury-induced neurotoxicity. Oct 21, 2011

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Pubmed Data : Neurochem Res. 2011 Oct 21. Epub 2011 Oct 21. PMID: 22015977

Article Published Date : Oct 21, 2011

Study Type : Animal Study

Additional Links

Substances : DHEA (Dehydroepiandrosterone)

Diseases : Excitotoxicity , Mercury Poisoning, Vaccine-induced Toxicity

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Mercury, Thimerosal

Adverse Pharmacological Actions : Neurotoxic

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Neonatal HBV vaccination of mice results in neurobehavioral impairments in early adulthood.Aug 01, 2016

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Pubmed Data : Psychoneuroendocrinology. 2016 Aug 2 ;73:166-176. Epub 2016 Aug 2. PMID: 27501128

Article Published Date : Aug 01, 2016

Study Type : Animal Study

Additional Links

Anti Therapeutic Actions : Vaccination: Hepatitis B

Adverse Pharmacological Actions : Neurotoxic

[+]

Neonicotinoid exposure alters the transcriptome of the developing mammalian brain in a similar way to nicotine exposure.Oct 03, 2016

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Pubmed Data : Int J Environ Res Public Health. 2016 Oct 4 ;13(10). Epub 2016 Oct 4. PMID: 27782041

Article Published Date : Oct 03, 2016

Study Type : Animal Study

Additional Links

Diseases : Pesticide Toxicity

Problem Substances : Pesticides

Adverse Pharmacological Actions : Neurotoxic

[+]

Oral aspartame significantly altered behaviour, anti-oxidant status and morphology of the hippocampus in mice.Dec 30, 2016

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Pubmed Data : Neurobiol Learn Mem. 2016 Dec 31 ;139:76-88. Epub 2016 Dec 31. PMID: 28049023

Article Published Date : Dec 30, 2016

Study Type : Animal Study

Additional Links

Problem Substances : Aspartame

Adverse Pharmacological Actions : Neurotoxic

[+]

Our findings suggest that BPA inhibits nerve conduction in a manner independent of estrogen receptors.Jun 30, 2017

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Pubmed Data : Biochem Biophys Rep. 2017 Jul ;10:145-151. Epub 2017 Mar 23. PMID: 28955742

Article Published Date : Jun 30, 2017

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity

Problem Substances : Bisphenol A

Adverse Pharmacological Actions : Neurotoxic

[+]

Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response.Feb 28, 2014

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Pubmed Data : Toxicol Sci. 2014 Mar ;138(1):139-47. Epub 2013 Dec 21. PMID: 24361869

Article Published Date : Feb 28, 2014

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Paraquat could negatively influence the learning and memory abilities of developing mice.May 31, 2011

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Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Jun ;29(6):437-9. PMID: 22096857

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Pubmed Data : Metab Brain Dis. 2015 Oct ;30(5):1193-206. Epub 2015 Jun 3. PMID: 26033310

Article Published Date : Oct 01, 2015

Study Type : Animal Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Learning disorders, Memory Disorders

Additional Keywords : Brain Function, electromagnetic radiation, EMF

Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation

Adverse Pharmacological Actions : Neurotoxic

[+]

Pumpkin fruit peel has a protective effect against carbon tetrachloride induced neurotoxicity.Oct 31, 2014

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Pubmed Data : Pak J Pharm Sci. 2014 Nov ;27(6):1967-73. PMID: 25362619

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Pubmed Data : Iran J Pharm Res. 2016 ;15(4):834-841. PMID: 28243280

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Mercury Poisoning, Multiple Sclerosis

Problem Substances : Mercury

Adverse Pharmacological Actions : Neurotoxic

[+]

Repetitive administration of aluminium to neonatal mice in amounts comparable to those to children receive via routine vaccinations result in neurodisruptive effects.Oct 31, 2013

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Pubmed Data : J Inorg Biochem. 2013 Nov ;128:237-44. Epub 2013 Jul 19. PMID: 23932735

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Pubmed Data : Neurosci Lett. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21763754

Article Published Date : Jul 08, 2011

Study Type : Animal Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies

Problem Substances : Atorvastatin, Statin Drugs

Adverse Pharmacological Actions : Neurotoxic

[+]

Statin drugs exhibit myotoxic, neurotoxic, hepatotoxic and testicule damaging properties in the anima model.Jul 01, 1996

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Pubmed Data : J Occup Health. 2004 Sep ;46(5):359-64. PMID: 15492452

Article Published Date : Aug 31, 2004

Study Type : Animal Study

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Pubmed Data : J Clin Diagn Res. 2016 Aug ;10(8):AF01-6. Epub 2016 Aug 1. PMID: 27656427

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Electromagnetic Radiation

Anti Therapeutic Actions : Electromagnetic Radiation, Mobile Phone Radiation

Adverse Pharmacological Actions : Neurotoxic

[+]

The presence of nanoplastics can increase BPA bioavailability and cause neurotoxicity in adult zebrafish.Aug 04, 2017

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Pubmed Data : Sci Total Environ. 2017 Aug 5 ;609:1312-1321. Epub 2017 Aug 5. PMID: 28793400

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Pubmed Data : Mol Psychiatry. 2004 Sep ;9(9):833-45. PMID: 15184908

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Pubmed Data : J Physiol Pharmacol. 2012 Jun ;63(3):277-83. PMID: 22791642

Article Published Date : Jun 01, 2012

Study Type : Animal Study

Additional Links

Additional Keywords : Vaccine Research

Problem Substances : Mercury, Thimerosal

Adverse Pharmacological Actions : Neurotoxic

[+]

This animal study suggests RF-EMF radiation stresses the brain.Mar 01, 2017

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Pubmed Data : Korean J Physiol Pharmacol. 2017 Mar ;21(2):179-188. Epub 2017 Feb 21. PMID: 28280411

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Treatment with quercetin may represent a therapeutic strategy to attenuate the neuronal death against aluminum-induced neurodegeneration.Mar 01, 2016

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Pubmed Data : Neuroscience. 2016 Mar 2. Epub 2016 Mar 2. PMID: 26944603

Article Published Date : Mar 01, 2016

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Aluminum Toxicity , Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

[+]

Triclosan can induce neurodegenerative effects in developing rat brains.Dec 31, 2015

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Pubmed Data : Biomol Ther (Seoul). 2016 Jan ;24(1):99-107. Epub 2016 Jan 1. PMID: 26759708

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Additional Keywords : Neural Stem Cells

Problem Substances : Triclosan

Adverse Pharmacological Actions : Neurotoxic

[+]

Vitamin E protects against oxidative and neurological damage caused by formaldehyde.May 01, 2005

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Pubmed Data : J Chem Neuroanat. 2005 May ;29(3):173-8. PMID: 15820619

Article Published Date : May 01, 2005

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases :

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View the Evidence: 395 Abstracts with Neurotoxic Research

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As thimerosal was removed from childhood vaccines, the number of neurodevelopmental disorders decreased in the US.Jun 01, 2006

Children who live in a fluorosis area have 5 times higher odds of developing low IQ than those who live in a nonfluorosis area or a slight fluorosis area.Jan 01, 2008

Children who live in an arsenicosis area or a slight arsenicosis area have lower IQ than those who live in a non-arsenicosis area.Jan 01, 2009

Dental amalgams (mercury exposure) increase the risk of multiple sclerosis. Jan 01, 2007

Exposure to high levels of fluoride may adversely influence children's intelligence development.Dec 01, 2008

Exposure to mercury from thimerosal-containing vaccines was associcated with an increased risk of neurodevelopmental problems in infants from 1992-1997.Apr 01, 2005

Oseltamivir for treatment of influenza in infants less than one year results in complications in 54% of the patients with the most serious of which were meningitis in 1 infant (1%), pneumonia in 9 (6%), and otitis media in 2 (1%)Jun 01, 2010

Oseltamivir has been reported to cause neuropsychiatric disorders in children and may be particularly dangerous to infants.Oct 01, 2006

Prenatal stress inhibits neuronal maturation in offspring. Aug 10, 2011

Rates of autism, speech disorders, mental retardation, infantile spasms, and thinking abnormalities were higher in children exposured to higher thimerosal levels.Aug 01, 2006

Tamoxifen interferes with cognitive function in breast cancer patients. Nov 01, 2000

The WHO reports 71,471 seizures from a variety of neuroactive drugs between 1968-2006.Mar 01, 2010

There is good evidence to support the existence of both metabolic and neurological adverse effects in children treated with second-generation antipsychotics.Jul 31, 2011

Thimersol exposure in infants is associated with an increase risk for tics. Sep 01, 2004

Thimersol exposure is associated with tics and delayed language acquisition in infants.Nov 01, 2003

A high prevalence of gluten sensitivity is found in sporadic and hereditary cerebellar ataxia.Apr 01, 2001

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.Nov 01, 2009

Aluminum vaccine adjuvants appear to contribute to the rising prevalence of autism.Nov 01, 2011

Antigliadin antibodies are found at a higher prevalence in Cuban patients with spinocerebellar ataxia type 2.Mar 01, 2008

Celiac disease is associated with ataxic syndromes without definite diagnosis, suggesting that it plays a part in the pathogenesis of some ataxic syndromes.Jan 01, 1999

Children's growth and intelligence can be adversely affected by fluoride and arsenic exposure in drinking water.Apr 01, 2007

Chronic consumption of proton pump inhibitors may increase the risk for Alzheimer disease.Apr 01, 2010

Cigarette smoking is associated with increased risk for ALS. Jan 01, 1999

Circulating levels of autophagy markers were low in children with higher fluoride body burden and lower intelligence quotient scores.Aug 31, 2019

Cognitive impairment and associated loss in brain white microstructure in aircrew members exposed to engine oil fumes.May 31, 2016

Decreased brain volume in adults with childhood lead exposure.May 26, 2008

Disaster-related prenatal maternal stress influences birth outcomes, including lower head circumference.Jul 22, 2011

Epilepsy with cerebral calcifications of unexplained origin may likely be caused by undiagnosed celiac disease.Aug 22, 1992

Exposure of pregnant women to emissions of PAHs from the coal-burning plant, in combination with prenatal exposure to envrionmental tobacco smoke, may have adversely affected cognitive function of children at age 5.Mar 01, 2012

Exposure to fluoride and arsenic in drinking water is associated with decreased intelligence in children.Jan 01, 2007

Food allergies and migraine.Dec 31, 1969

Gluten sensitivity is a clinically confirmed problem in multiple sclerosis.Sep 01, 2009

Gluten sensitivity is associated with sporadic cerebellar ataxia in Taiwan.Dec 01, 2010

Greater exposure to bisGMA-based (BPA-containing) dental composite restorations was associated with impaired psychosocial function in children.Jul 15, 2012

Headache and CNS white matter abnormalities may be associated with gluten sensitivity.Feb 13, 2001

Headache and mechanical sensitization of human pericranial muscles after repeated intake of monosodium glutamate (MSG).Nov 30, 2013

Heavy metal accumulation and associated biochemical alterations are found in Autistic Spectrum Disorder.Jul 14, 2011

High exposure to ethylmercury from thimerosal-containing vaccines in the first month of life increases the risk of subsequent development of neurologic development impairment.Dec 31, 1969

High iodine and high fluorine adversely effects the intelligence and health of children.Oct 01, 1994

Highly significant increases compared with controls were found in patients with multiple sclerosis for IgA and IgG antibodies against gliadin and gluten and IgA antibodies against casein.Oct 01, 2004

Hospitalized patients with overdoses of Wellbutrin XL were studied for agitation, tremors, hallucinations, and seizures with delayed seizure onset noted.Sep 30, 2009

Hyperexcitable brain and refractory coeliac disease: a new syndrome.Oct 31, 2013

Individuals with schizophrenia have a novel immune response to gluten.May 01, 2010

Lead and mercury negatively affect infant milestones like walking and talking.Apr 01, 2014

Lead exposure at younger age significantly impacts a child's later neurodevelopment.Aug 09, 2011

Lead may contribute to the pathogenesis of autism. Jul 06, 2011

Lipid lowering drugs increase the risk of peripheral neuropathy.Dec 01, 2004

Long-term exposure to statin drugs may substantially increase the risk of polyneuropathy.May 14, 2002

Long-term treatment with statins caused a clinically silent but still definite damage to peripheral nerves when the treatment lasts longer than 2 years.Sep 03, 2011

Long-term treatment with statins might cause a clinically silent but still electrophysiologically definite damage to peripheral nerves.Dec 01, 2007

Lovastatin may adversely affect neuropsychological tests of attention and psychomotor speed.May 01, 2000

Markers of gluten sensitivity and celiac disease are increased in recent-onset psychosis and multi-episode schizophrenia.Jul 01, 2010

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.Sep 01, 2011

Mercury and elevated testosterone in autistic children may work synergistically and more studies should be conducted to understand the relationship.Jan 01, 2005

Mercury exposure from thimerosal containing childhood vaccines raised the subsequent risk of diagnosis of emotional disturbances.Jan 18, 2017

Mercury levels are 1.9 times higher in subjects diagnosed with autism spectrum disorders.Jan 01, 2010

Milk and bacterial proteins may produce neuron-specific antigens in children with autism. Aug 01, 2002

Neurological symptoms occur in 6-10% of those with celiac disease, with cerebella ataxia being the most frequent symptom.Dec 15, 2009

Occupational exposures to agricultural chemicals is associated with increased risk for ALS. Jun 15, 1997

Organic-Hg exposure from thimerosal-containing hepatitis B vaccine led to an increased risk of neurodevelopmental disorder diagnosis.Aug 31, 2014

Pepper spray may result in damage to corneal nerve terminals with physical symptoms that last at least a week. Jul 01, 2000

Perfluorinated compound exposure in children has been linked to impulse control problems. Jun 17, 2011

Persons with schizophrenia have higher than expected titers of antibodies related to celiac disease and gluten sensitivity.Jan 01, 2011

Pesticide exposure is associated with an increased risk of amyotrophic lateral sclerosis.Jan 01, 2010

Pesticide exposure is associated with psychological distress and suicidal ideation. Nov 01, 2010

Porphyrin patterns in autism may indicate mercury toxicity. The authors emphasize that additional research should be conducted to explore the role of mercury in autism.Aug 01, 2006

Psychiatric adverse reactions associated with cholesterol-lowering drugs have been reported. Jan 01, 2007

Sensory ganglionopathy may be a manifestation of gluten sensitivity.Sep 14, 2010

Severity of autism may correlated with the number of maternal dental amalgams.Jan 01, 2009

Simvastatin inhibits brain cholesterol biosynthesis without positively alterting molecular indices of Alzheimer disease pathology. Jul 01, 2010

Statin drug use results in decrements in cognitive functioning. Dec 01, 2004

Statin drugs are associated with adverse mental effects.Sep 20, 1997

Neurotoxic

View the Evidence:
395 Abstracts with Neurotoxic Research