Aging: Brain

Name	AC	CK
Resveratrol	3	24
Ginkgo biloba	8	21
Flavonoids	4	16
Green Tea	4	16
Bacopa	4	15
Melatonin	7	14
Antioxidant formulas	1	10
Black Tea	1	10
Multivitamin	1	10
Wine	1	10
Catechin	4	8
Curcumin	4	8
Blueberry	3	6
Lotus	3	6
Phosphatidylserine	3	6
Acetyl-l-carnitine	3	5
Alpha-Lipoic Acid	2	4
Anthocyanins	2	4
Apples	2	4
Grape Seed Extract	2	4
OPC (Oligomeric Proanthocyanidins)	2	4
Polyphenols	2	4
Tea	2	4
Vitamin E	2	4
Folic Acid	2	3
Walnut	2	3
Blackberry	1	2
Cannabinoids	1	2
Carnosic Acid	1	2
Chinese Skullcap	1	2
Cistanche deserticola	1	2
Coenzyme Q10	1	2
Cryptoxanthin	1	2
DHA (Docosahexaenoic Acid)	1	2
GlyceroPhosphoCholine (alpha-GPC)	1	2
Huperzine	1	2
Icariin	1	2
Krill	1	2
Orange: Mandarin	1	2
Persimmon	1	2
Plum	1	2
Polyunsaturated Fatty Acids (PUFAs)	1	2
Pterostilbene	1	2
Rehmannia	1	2
Rice Bran	1	2
Rosemary	1	2
Rosmarinic acid	1	2
Soybean Oil	1	2
Spearmint	1	2
Spinach	1	2
Spirulina	1	2
St. Johns Wort	1	2
Strawberry	1	2
Vitamin B-6	1	2
Berries: All	1	1
Carnosine	1	1
EGCG (Epigallocatechin gallate)	1	1
Grape	1	1
Vitamin C	1	1

Name	AC	CK	Focus
Insulin	1	2

Name	AC	CK
Exercise	3	21
Dietary Modification: Mediterranean Diet	1	10
Meditation	1	10
Yoga	1	10
Acupuncture	3	6
Moxibustion	1	2
Fasting/Caloric Restriction	1	1
Music	1	1

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Nov 26 ;11(12). Epub 2019 Nov 26. PMID: 31779179

Article Published Date : Nov 25, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin D, Yoghurt

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

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Ginkgo biloba improves cognitive functioning and behavioral symptoms in patients with age-associated cognitive impairment or dementia. Jan 01, 2007

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Pubmed Data : Arzneimittelforschung. 2007;57(1):4-11. PMID: 17341003

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba

Diseases : Aging: Brain , Cognitive Decline/Dysfunction, Dementia

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Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation.Jun 13, 2019

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Pubmed Data : J Nutr. 2009 Jan;139(1):120-7. Epub 2008 Dec 3. PMID: 19056649

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Substances : Black Tea, Flavonoids, Green Tea, Wine

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

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Leisure activity involvement may help delay cognitive impairment.Sep 30, 2017

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Spearmint extract improves working memory in men and women with age-associated memory impairment.Dec 31, 2017

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Pubmed Data : J Altern Complement Med. 2018 Jan ;24(1):37-47. Epub 2018 Jan 9. PMID: 29314866

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Spearmint

Diseases : Aging: Brain , Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

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Superior effects of modified Chen-Style Tai Chi versus 24-style Tai Chi on cognitive function, fitness, and balance performance in adults over 55.May 03, 2019

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Pubmed Data : Brain Sci. 2019 May 4 ;9(5). Epub 2019 May 4. PMID: 31060221

Article Published Date : May 03, 2019

Study Type : Human Study

Additional Links

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Therapeutic Actions : Tai Chi

Pharmacological Actions : Neuroprotective Agents

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Yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.Dec 31, 2013

Article Published Date : Apr 01, 2008

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba, Phosphatidylserine, Vitamin B-6, Vitamin E

Diseases : Aging: Brain , Memory Disorders

Additional Keywords : Plant Extracts

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Pubmed Data : J Alzheimers Dis. 2006 Aug;9(3):243-51. PMID: 16914834

Chronic administration of red ginseng and black ginseng may decrease the cognitive deficits associated with normal aging.Dec 31, 2016

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Pubmed Data : Food Sci Biotechnol. 2017 ;26(6):1743-1747. Epub 2017 Oct 16. PMID: 30263713

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginseng, Ginseng (Korean)

Diseases : Aging: Brain

Pharmacological Actions : Neuroprotective Agents

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Chronic dietary supplement with multi-species live microorganisms can alter brain metabolites in aging rats and have beneficial effects on memory.Jun 04, 2017

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Pubmed Data : Neurobiol Learn Mem. 2017 Jun 5. Epub 2017 Jun 5. PMID: 28602659

Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice.Jan 01, 2008

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Pubmed Data : Biofactors. 2008;34(4):263-71. PMID: 19850981

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Catechin , Green Tea, Tea

Diseases : Aging, Aging: Brain , Learning disorders

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Dietary supplementation with blueberry, spinach, or strawberry reverses age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits. Nov 01, 2002

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Pubmed Data : J Gastroenterol. 2002 Nov;37 Suppl 14:67-72. PMID: 10479711

Article Published Date : Nov 01, 2002

Study Type : Animal Study

Additional Links

Substances : Blueberry, Spinach, Strawberry

Diseases : Aging, Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Disease Regression, Plant Extracts

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Extracts from spearmint and rosemary have beneficial effects on learning and memory and brain tissue markers of oxidation.Aug 11, 2016

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Pubmed Data : Physiol Behav. 2016 Aug 12. Epub 2016 Aug 12. PMID: 27527000

Ginseng extracts may suppress the cognitive decline associated with aging.Sep 30, 2017

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Pubmed Data : J Ginseng Res. 2017 Oct ;41(4):615-619. Epub 2017 Jun 20. PMID: 29021712

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Ginseng

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

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Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging.Dec 31, 2013

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Pubmed Data : Int J Mol Sci. 2020 Mar 4 ;21(5). Epub 2020 Mar 4. PMID: 32143275

Article Published Date : Mar 03, 2020

Study Type : Animal Study

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Aging: Brain , Neurodegenerative Diseases

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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Oligomeric proanthocyanidins improve memory in age-accelerated mice. Feb 01, 2010

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Pubmed Data : Br J Nutr. 2010 Feb;103(4):479-89. Epub 2009 Oct 13. PMID: 19822031

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : OPC (Oligomeric Proanthocyanidins)

Diseases : Aging, Aging: Brain , Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts, Proanthocyanidins

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Resveratrol preserves cerebrovascular density and cognitive function in aging mice.Jan 01, 2009

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Pubmed Data : Front Aging Neurosci. 2009;1:4. Epub 2009 Dec 9. PMID: 20552055

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Aging: Brain

Pharmacological Actions : Neuroprotective Agents

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Royal jelly delays motor functional impairment during aging in genetically heterogeneous male mice.Aug 31, 2018

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Pubmed Data : J Neurol Sci. 2009 Feb 15 ;277(1-2):58-64. Epub 2008 Nov 12. PMID: 19007942

Article Published Date : Feb 14, 2009

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Aging: Brain , Neurodegenerative Diseases

Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

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These results underscore the therapeutic potential of pterostilbene supplementation for age-related cognitive decline.Dec 31, 2018

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Pubmed Data : J Nutr Biochem. 2017 Jul 27 ;49:133-140. Epub 2017 Jul 27. PMID: 28950154

Article Published Date : Jul 26, 2017

Study Type : Animal Study

Additional Links

Substances : Xanthohumol

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Risk Reduction

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2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside promotes expression of the longevity gene Klotho.Dec 31, 2015

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Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:3128235. Epub 2016 Nov 3. PMID: 27885332

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : 2,3,5,4'-tetrahydroxystilbene-2-O-β -D-glucoside (THSG)

Diseases : Aging, Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Osteoprotective , Renoprotective

Additional Keywords : Gene Expression Regulation

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Bacopa monnieri is a potential therapeutic antioxidant to reduce oxidative stress and improve cognitive function.Dec 31, 2014

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Pubmed Data : Nihon Rinsho. 2016 Sep ;74(9):1577-1582. PMID: 30557496

Article Published Date : Aug 31, 2016

Study Type : Review

Additional Links

Diseases : Aging: Brain

Therapeutic Actions : Exercise

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Exercise has been found to lead to cognitive improvement in normal aging.Dec 31, 2015

The findings indicate that the nut consumption may contribute to the delay of cognitive decline in aging.Jan 31, 2018

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Pubmed Data : Curr Alzheimer Res. 2018 Feb 1. Epub 2018 Feb 1. PMID: 29422003

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Pubmed Data : Antioxidants (Basel). 2019 Mar 11 ;8(3). Epub 2019 Mar 11. PMID: 30862106

Article Published Date : Mar 10, 2019

Study Type : Review

Additional Links

Substances : Coenzyme Q10

Diseases : Aging: Brain , Mitochondrial Dysfunction , Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

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Resveratrol has a neuroprotective effect in a rat model of aging. Nov 30, 2008

A blueberry powder could can facilitate better episodic memory performance and improve cardiovascular function over 6 months.May 22, 2018

A high intake of nuts may protect older adults from cognitive decline.Nov 21, 2019

Adherence to the Mediterranean may positively affect not only the risk of AD, but also of predementia syndromes and their progression to overt dementia. May 01, 2011

Art therapy is associated with sustained improvement in cognitive function in the elderly with mild neurocognitive disorder.Nov 08, 2018

Bacopa enhances cognitive performance in the aging.Jul 01, 2008

Being physically active during early adulthood and midlife contributes to prevention of poor subjective cognitive function in late-life.Nov 16, 2017

Better B-vitamin status may have a role in impacting positively on mental health in older adults. Jan 24, 2019

Cycling in appears to improve some aspects of cognitive function and mental health.Dec 31, 2018

Daily consumption of pomegranate juice may stabilize the ability to learn visual information over a 12-month period.Nov 11, 2019

Dewaxed brown rice has the potential to be a useful staple food that maintains brain homeostasis among elderly individuals.Dec 31, 2018

Dietary intake of riboflavin and unsaturated fatty acid can improve the multi-domain cognitive function in middle-aged and elderly populations.Dec 31, 2018

Flavonol intake and cognitive decline in middle-aged adults.Nov 30, 2015

Fortified yogurts with vitamin D twice a day maintained global cognitive performance and vitamin D status in older females.Nov 25, 2019

Ginkgo biloba improves cognitive functioning and behavioral symptoms in patients with age-associated cognitive impairment or dementia. Jan 01, 2007

Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation.Jun 13, 2019

Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. Dec 31, 2017

Horticultural therapy could improve the stress levels and physical functional abilities of elderly people with mental health problems.May 31, 2018

Impact of coffee, wine, and chocolate consumption on cognitive outcome and MRI parameters in old age.Sep 30, 2018

In this study the brains of long term meditators at the age of 50 were estimated to be 7.5 years younger than controls. Apr 10, 2016

Inflammation is particularly detrimental in inactive older adults and may exacerbate the negative effects of physical inactivity on brain.May 08, 2016

Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance.Jan 01, 2009

Leisure activity involvement may help delay cognitive impairment.Sep 30, 2017

Long-term tai chi training is associated with better dual-task postural control and cognition in aging adults.May 31, 2018

Nut consumption was inversely associated with cognition decline.Dec 31, 2018

Photobiomodulation improves the frontal cognitive function of older adults.Jan 31, 2019

Physical activity is associated with decreasing age-related losses of neurological function. Mar 24, 2011

Physical exercise with music reduces gray and white matter loss in the frontal cortex of elderly people.Dec 31, 2016

Spearmint extract improves working memory in men and women with age-associated memory impairment.Dec 31, 2017

Superior effects of modified Chen-Style Tai Chi versus 24-style Tai Chi on cognitive function, fitness, and balance performance in adults over 55.May 03, 2019

Supplementation with antioxidant vitamins and minerals slows cognitive decline in middle-aged adults.Jan 01, 2011

The effects of drumming on working memory in older adults.May 03, 2018

The effects of lutein and zeaxanthin on resting state functional connectivity in older Caucasian adults.Jan 23, 2019

The impact of exposure to air pollution on cognitive performance.Sep 10, 2018

There was a greater cortical thickness in the left prefrontal cortex of healthy elderly women who trained yoga for a minimum of 8 years.Dec 31, 2016

These findings show that lutein and zeaxanthin influence white matter integrity, particularly in regions vulnerable to age-related decline.Nov 16, 2017

Ultra-high hydrostatic pressurized brown rice has a protective effect against age-related decline in brain cognition and motivation.Dec 31, 2018

Yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.Dec 31, 2013

"Brain insulin impairs amyloid-beta(1-40) clearance from the brain."Oct 26, 2004

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.May 07, 2017

A combination of phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine improves short term memory in aging beagles. Apr 01, 2008

A high consumption of unsaturated fatty acids is associated with better memory and greater longevityJan 01, 2011

Acetyl-l-carnitine and R-alpha-lipoic acid partially reverses brain decay and RNA/DNA oxidation associated with memory loss in rats. Feb 19, 2002

Acupuncture could be a potential intervention to retard molecular events with aging in mammals.May 15, 2006

Acupuncture exhibits anti-brain aging properties. Jan 01, 2006

Acupuncture may delay brain ageing in SAMP8 mice by reducing oxidative protein damage and promoting Hsp84 and Hsp86 expression.Aug 14, 2019

Acupuncture significantly reduces aging-related changes in the cerebrum of age-accelerated mice. Jan 01, 2005

Alpha-GPC may be effective in slowing down the expression of structural changes occuring in aging brain.Sep 01, 1994

Anthocyanins from black chokeberry delayed aging-related degenerative changes of the brain.Jul 25, 2017

Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory.Jan 01, 2010

Antioxidant effect of peony seed oil on aging mice.Dec 31, 2016

Apple juice concentrate prevents oxidative damage and impaired maze performance in aged mice.Jul 01, 2009

Ascorbic acid ameliorates D-galactose-induced impairments through anti-oxidative and anti-inflammatory effects.Jan 14, 2019

Bacopa extract reduces brain amyloid levels in mice by as much as 60%. Aug 01, 2006

Berberine markedly ameliorates aging-related reductions in cognitive ability and muscular function.Dec 31, 2017

Beta-cryptoxanthin, plentiful in Japanese mandarin orange, prevents age-related cognitive dysfunction and oxidative damage in senescence-accelerated mouse brain.Jan 01, 2011

Blackberries improve motor and cognitive performance in aged rats. Jun 01, 2009

Blueberry attenuates microglial activation in the brain suggesting it may attenuate age-induced inflammation. Dec 14, 2009

Brahmi exerts distinct age-related effects on the cell-mediated immune responses through selective modulation of antioxidant enzyme activities.Jan 31, 2013

Calorie restriction protects neural stem cells from age-related deficits in the subventricular zoneJan 07, 2019

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.Apr 30, 2009

Catalpol, a compound found within Rehmannia, may ameliorate age-related brain dsyfunction. Dec 06, 2006

Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice.Jun 30, 2018

Chronic administration of red ginseng and black ginseng may decrease the cognitive deficits associated with normal aging.Dec 31, 2016

Chronic dietary supplement with multi-species live microorganisms can alter brain metabolites in aging rats and have beneficial effects on memory.Jun 04, 2017

Chrysanthemum indicum might be an alternative and promising agent for the treatment of aging and age-associated brain and liver diseasesJan 01, 2019

Cistanche deserticola exhibits anti-aging properties in mice. Sep 01, 2008

Coenzyme Q(10) supplementation reverses age-related impairments in spatial learning and lowers protein oxidation.Nov 09, 2012

Consumption of blueberries may reverse some age-related deficits in cognition.Feb 16, 2019

Curcuma treatment prevents cognitive deficit and alteration of neuronal morphology in the limbic system of aging rats.Feb 28, 2017

Curcumin counteracts the aluminium-induced ageing-related alterations in the rat brain.Aug 01, 2009

Aging: Brain

View the Evidence:
168 Abstracts with Aging: Brain Research