Brain Inflammation

Name	AC	CK
Curcumin	30	45
Resveratrol	14	21
Ginsenosides	12	20
Astaxanthin	8	14
Cannabidiol	10	14
Flavonoids	10	14
Apigenin	7	13
Luteolin	9	13
Thymoquinone	8	13
Alpha-Lipoic Acid	3	12
Berberine	6	12
Cannabinoids	9	12
Paeoniflorin	6	12
Polyphenols	8	12
EGCG (Epigallocatechin gallate)	8	11
Frankincense	2	11
Gastrodin	6	10
Ginkgo biloba	5	10
Hesperidin	5	10
Lycopene	6	10
Melatonin	6	10
Probiotics	1	10
Yoghurt	1	10
Ashwagandha	6	9
Genistein	5	9
Ginger	5	9
Tanshinone IIA	6	9
Vitamin C	5	9
Chrysin	5	8
Huperzine	5	8
Biochanin A	4	7
Honokiol	4	7
Astragaloside	3	6
Blueberry	4	6
DHA (Docosahexaenoic Acid)	4	6
Fisetin	4	6
Silibinin	3	6
Arctigenin	3	5
Bee Venom	3	5
Betulinic acid	3	5
Caffeine	3	5
Carnosic Acid	3	5
Fish Oil	3	5
Gotu Kola	3	5
Hemp Seed	4	5
Naringenin	3	5
Nobiletin	3	5
Omega-3 Fatty Acids	4	5
Palmitoylethanolamide	3	5
Piperine	3	5
Polyunsaturated Fatty Acids (PUFAs)	3	5
Toona sinensis	3	5
6-Shogaol	2	4
Bacopa	3	4
Baicalein	2	4
Burdock	2	4
Chamomile	2	4
Citrus Peel	2	4
Coconut Oil	2	4
Crocin	2	4
Delta-tetrahydrocannabinol (THC)	3	4
Ellagic Acid	2	4
Eriodictyol	2	4
Garlic	3	4
Gingerol	2	4
Hydrogen Water	2	4
Isoliquiritigenin	2	4
Lion's Mane (Hericium Erinaceus)	2	4
Lychee	2	4
Magnolol	2	4
Neem	2	4
Nettle	2	4
Parthenolide	2	4
Quercetin	3	4
Rosmarinic acid	2	4
Selenium	2	4
Sesamin	2	4
Sesamol	2	4
Sweet Potato: Purple	2	4
Tangeretin	2	4
Theaflavins	2	4
Ume (Japanese apricot)	2	4
Urolithin A	2	4
Walnut	2	4
Anthocyanins	2	3
Beta-Caryophyllene	2	3
Butterbur	2	3
Catechols	2	3
Ginseng (Korean)	2	3
Glycyrrhizin	2	3
Hydroxytyrosol	2	3
Maple Syrup	2	3
Mulberry	2	3
NAC (N-acetyl-L-cysteine)	2	3
Peony	2	3
Pterostilbene	2	3
Puerarin	2	3
Punicalagin	2	3
Reishi Mushroom	2	3
Spirulina	2	3
Sulforaphane	2	3
Turmerones	2	3
Vitamin D	2	3
Vitexins	2	3
Acorus calamus	1	2
Amla Fruit	1	2
Arginine	1	2
Artesunate	1	2
Asiatic Acid	2	2
Bamboo	1	2
Bee Pollen	1	2
Berries: All	1	2
Bifidobacterium Longum	1	2
Black Tea	1	2
Boron	1	2
Butyrate	1	2
Caffeic acid phenethyl ester	1	2
Carnosine	1	2
Carvacrol	1	2
Chinese Skullcap	1	2
Chokeberry	1	2
Choline	1	2
Chrysanthemum Indicum	1	2
Citrus naringin	1	2
Crocetin	1	2
Dandelion	2	2
Diosmin	1	2
Dong Quai	1	2
Dopa bean	1	2
EPA (Eicosapentaenoic Acid)	1	2
Echinacea	1	2
Endocannabinoids	1	2
Essential Fatty Acids	1	2
Fermented Foods and Beverages	1	2
Ferulic acid	1	2
Fiber	1	2
Formononetin	1	2
Fucoxanthin	2	2
Gallic Acid	1	2
Gamma-Oryzanol	1	2
Gardenia	1	2
Ginseng	1	2
Glucosamine	1	2
Grape Seed Extract	1	2
Green Coffee Bean	1	2
Guduchi	1	2
Hibiscus sabdariffa	1	2
Indole-3-Carbinol	1	2
Isothiocyanates	2	2
Kefir	1	2
Krill	1	2
Lactobacillus helveticus	1	2
Lactobacillus probiotics	1	2
Licorice	1	2
Lithium	1	2
Lupeol	1	2
Magnesium	1	2
Mangosteen	1	2
Modified Citrus Pectin	1	2
Moringa oleifera	1	2
Moxibustion	1	2
Myricetin	2	2
Oleocanthal	1	2
Oleuropein	1	2
Olive Oil	1	2
Onion	1	2
P-Coumaric Acid	1	2
Paeonol	2	2
Pantothenic Acid (Vitamin B-5)	1	2
Paprika	1	2
Patchouli	1	2
Phloretin	1	2
Phyllanthus amarus	1	2
Pomegranate	2	2
Propolis: Bee	1	2
Propolis: Brazillian	1	2
Purslane	1	2
Riboflavin (Vitamin B-2)	1	2
Rice Bran	2	2
Rose	1	2
Rosemary	1	2
Rutin	1	2
St. Johns Wort	1	2
Tannic Acid	1	2
Tart Cherry	1	2
Tetrahydrocurcumin	1	2
Theanine	1	2
Thiamine (B-1)	1	2
Thymol	1	2
Tualang Honey	1	2
Turmeric	2	2
Vitamin B-12	1	2
Vitamin B-3 (Niacin)	1	2
Vitamin B-6	1	2
Zerumbone	1	2
Acacia catechu	1	1
Achillea fragrantissima	1	1
Agrimony	1	1
Apple	1	1
Arugula	1	1
Ayahuasca	1	1
Babchi	1	1
Benzyl isothiocyanate	1	1
Bergamot	1	1
Black Currant	1	1
Blackberry	1	1
Cannabigerol	1	1
Cannabinoids: Synthetic	1	1
Cannabis	1	1
Carnosol	1	1
Chaga Mushroom (Inonotus obliquus)	1	1
Chia	1	1
Cordyceps sinensis	1	1
Cysteine (see N-Acetylcysteine)	1	1
Diosgenin	1	1
Elderberry	1	1
Emodin	1	1
Fucoidan	1	1
Garlic: Aged	1	1
Goji	1	1
Gold (nanoparticles)	1	1
Green Tea	1	1
Gynostemma	1	1
Hawthorn	1	1
Hemp Protein	1	1
Hibiscus	1	1
Knema laurina	1	1
Mangiferin	1	1
Matairesinol	1	1
Oleanolic acid	1	1
Olive leaf extract	1	1
Persimmon	1	1
Prickly Pear Cactus	1	1
Pycnogenol (Pine Bark)	1	1
Red Wine Extract	1	1
Safflower	1	1
Sembung Leaf	1	1
Spermidine	1	1
Strawberry	1	1
Vanillin	1	1
Vitamin E	1	1
Wasabi	1	1
Watercress	1	1
Wine	1	1
Wogonin	1	1
Xanthohumol	1	1

Name	AC	CK
Aluminum	14	28
Mercury	3	16
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	12
Butyrophilin	1	10
Chlamydia Pneumoniae	1	10
Cow Milk	1	10
Streptococcal M Protein	1	10
Bisphenol A	3	5
Acrylamide	2	4
Morphine	2	4
Sodium Fluoride	2	4
Cadmium	2	3
Lead	2	3
Aluminum Chloride	1	2
Aspartame	1	2
Chlorpyrifos	1	2
Dexamethasone	1	2
Energy Drinks	1	2
Fluoride	1	2
Fluoxetine (trade name Prozac)	1	2
Glyphosate formulations	1	2
High Fructose Corn Syrup	1	2
Nanoparticles	1	2
Paraquat	1	2
Roundup (herbicide)	1	2
Simvastatin	1	2
Streptozotocin	1	2
Sugar Sweetened Beverages	1	2
Thimerosal	1	2
Amphetamine	1	1

Name	AC	CK
Exercise	10	32
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Electroacupuncture	5	10
Hyperbaric Treatment	3	6
Laser Treatment: Low-Level	3	6
Acupuncture	1	2
Cryotherapy	1	2
Dietary Modification: Low Calorie Diet	1	2
Exercise: Aerobic	1	2
Exercise: Endurance	1	2
Exercise: Swimming	1	2
Light-Emitting Diodes (LEDs) Therapy	1	1

Name	AC	CK
Vaccination: All	10	43
Vaccination: Mumps-Measles-Rubella (MMR)	2	13
Vaccination: Hexavalent	1	10
Vaccination: Measles	1	10
Vaccination: Adult Rubella	1	3
Vaccination: Hepatitis B	1	3
Vaccination: Mumps	1	3
Electromagnetic Field Harms	1	2
Electromagnetic Radiation	1	2
Electromagnetic Radiation: 1.8 GHz	1	2
Microwave Radiation	1	2
Nanotechnology	1	2
Vaccination: HPV (Gardasil)	1	2
Vaccination: Yellow Fever	1	1

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11.8% of 110 sudden infant death cases examined in the study occurred in temporal association with hexavalent vaccines.Mar 01, 2014

Click here to read the entire abstract

Pubmed Data : Curr Med Chem. 2014 Mar ;21(7):941-6. PMID: 24083600

Article Published Date : Mar 01, 2014

Study Type : Human Study

Additional Links

Diseases : Brain Inflammation , Encephalitis, Vaccine-induced Toxicity

Anti Therapeutic Actions : Vaccination: All, Vaccination: Hexavalent

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Boswellic acids could be used to reduce peritumoral edema associated with primary and secondary brain tumors.Dec 14, 2011

Click here to read the entire abstract

Pubmed Data : J Pharm Biomed Anal. 2011 Dec 15 ;56(5):998-1005. Epub 2011 Jul 29. PMID: 21855244

Article Published Date : Dec 14, 2011

Study Type : Human Study

Click here to read the entire abstract

Pubmed Data : Curr Top Behav Neurosci. 2016 Nov 10. Epub 2016 Aug 10. PMID: 27830574

Article Published Date : Nov 09, 2016

Study Type : Human Study

Additional Links

Diseases : Brain Inflammation , Depressive Disorder, Inflammation

Additional Keywords : Risk Factors

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Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents.Mar 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Adv. 2021 Apr ;7(15). Epub 2021 Apr 9. PMID: 33837086

Study Type : Human Study

Additional Links

Diseases : Autism Spectrum Disorders, Brain Inflammation

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Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias.Dec 15, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neurol Neurosurg Psychiatry. 2017 Dec 16. Epub 2017 Dec 16. PMID: 29248892

Article Published Date : Dec 15, 2017

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease, Brain Inflammation , Dementia: Lewy Body

Additional Keywords : Alzheimer's disease, Brain Inflammation, Dementia: Lewy Body

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The combined effects of yogurt and exercise in healthy adults: Implications for biomarkers of depression and cardiovascular diseases.Sep 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Nutr. 2018 Oct ;6(7):1968-1974. Epub 2018 Sep 7. PMID: 30349687

Article Published Date : Sep 30, 2018

Pubmed Data : J Inorg Biochem. 2015 Aug 1. Epub 2015 Aug 1. PMID: 26265215

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Diseases : Brain Inflammation , C-Reactive Protein, Inflammation

Additional Keywords : Increased Risk

Problem Substances : Aluminum

Adverse Pharmacological Actions : Neurotoxic

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Mercury stimulates VEGF and IL-6 release from human mast cells which could disrupt the blood-brain-barrier and permit brain inflammation.Mar 11, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neuroinflammation. 2010 Mar 11 ;7:20. Epub 2010 Mar 11. PMID: 20222982

Article Published Date : Mar 11, 2010

Study Type : Human In Vitro

Additional Links

Diseases : Autism, Autism Spectrum Disorders, Brain Inflammation

Additional Keywords : Blood Brain Barrier, Heavy Metals and Autism, Vaccine Research

Problem Substances : Mercury

Adverse Pharmacological Actions : Blood Brain Barrier Injury, Inflammatory, Interleukin-6 up-regulation, Vascular Endothelial Growth Factor C Up-Regulation

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This demonstrates the broad neuroprotective action of apigenin against AD pathogenesis in a human disease model.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 ;6:31450. Epub 2016 Aug 12. PMID: 27514990

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6-shogaol may play a role in inhibiting glial cell activation and reducing memory impairment in animal models of dementia. Jun 19, 2014

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Pubmed Data : Biochem Biophys Res Commun. 2014 Jun 20 ;449(1):8-13. Epub 2014 May 2. PMID: 24796668

Article Published Date : Jun 19, 2014

Study Type : Animal Study

Additional Links

Substances : 6-Shogaol

Diseases : Brain Inflammation , Dementia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

A cecal slurry mouse model of sepsis leads to acute consumption of vitamin C in the brain.Mar 25, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Behav Immun. 2019 07 ;79:228-235. Epub 2019 Feb 7. PMID: 30738841

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Pubmed Data : Antioxidants (Basel). 2020 Sep 3 ;9(9). Epub 2020 Sep 3. PMID: 32899274

Article Published Date : Sep 02, 2020

Study Type : Animal Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Brain Inflammation , Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

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Anti-neuroinflammatory effect of alantolactone through the suppression of the NF-κB and MAPK signaling pathways.Jan 17, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cells. 2019 07 18 ;8(7). Epub 2019 Jul 18. PMID: 31323885

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Pubmed Data : Neurotherapeutics. 2016 Dec 7. Epub 2016 Dec 7. PMID: 27928708

Article Published Date : Dec 06, 2016

Study Type : Transgenic Animal Study

Additional Links

Substances : Ashwagandha

Diseases : Amyotrophic lateral sclerosis (ALS), Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

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Astaxanthin ameliorates lipopolysaccharide-induced neuroinflammation, oxidative stress and memory dysfunction.Feb 17, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

B vitamins had the potential for treatment of neuroinflammation and neuroregeneration.Dec 16, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2019 Dec 17 ;24(24). Epub 2019 Dec 17. PMID: 31861069

Article Published Date : Dec 16, 2019

Study Type : Animal Study

Additional Links

Substances : Pantothenic Acid (Vitamin B-5), Riboflavin (Vitamin B-2), Thiamine (B-1) , Vitamin B-12, Vitamin B-3 (Niacin), Vitamin B-6

Diseases : Brain Inflammation , Nerve Injuries, Neurodegenerative Diseases, Peripheral Nerve Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Baicalein is a promising novel analgesic agent for cancer-induced bone pain.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Eur J Pharmacol. 2018 May 17 ;832:56-66. Epub 2018 May 17. PMID: 29778746

Article Published Date : May 16, 2018

Study Type : Animal Study

Additional Links

Substances : Betulinic acid

Diseases : Brain Inflammation , Cognitive Decline/Dysfunction, Dementia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Brain-derived neurotrophic factor modulator, Neuroprotective Agents

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Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration.Jan 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Immunol. 2018 ;9:1832. Epub 2018 Aug 14. PMID: 30154787

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Pubmed Data : Biomolecules. 2019 Nov 8 ;9(11). Epub 2019 Nov 8. PMID: 31717470

Article Published Date : Nov 07, 2019

Study Type : Animal Study

Additional Links

Substances : Caffeine

Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

[+]

Calorie restriction protects neural stem cells from age-related deficits in the subventricular zoneJan 07, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

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Pubmed Data : Inflammopharmacology. 2016 Nov 16. Epub 2016 Nov 16. PMID: 27853890

Article Published Date : Nov 15, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Brain Inflammation , Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Inflammatory Agents, Brain Inflammation, CURCUMIN, Interleukin-1 beta downregulation, Natural Substance Synergy, Parkinson's disease, Piperine

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Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

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Pubmed Data : Pharmacology. 2016 Jan 30 ;97(3-4):151-160. Epub 2016 Jan 30. PMID: 26828892

Pubmed Data : Inflammation. 2021 Aug ;44(4):1381-1395. Epub 2021 Jan 29. PMID: 33511484

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Microbiome. 2019 Jun 29 ;7(1):98. Epub 2019 Jun 29. PMID: 31255176

Article Published Date : Jun 28, 2019

Study Type : Animal Study

Additional Links

Substances : Essential Fatty Acids

Diseases : Brain Inflammation , Dysbiosis, High Fructose Diet, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Neuroprotective Agents

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Diosmin could be considered as potential candidate for novel anti-Alzheimer's disease therapy.Jan 14, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neurotox Res. 2019 Feb ;35(2):318-330. Epub 2018 Sep 21. PMID: 30242626

Article Published Date : Jan 31, 2019

F. mume is a potentially valuable drug or nutraceutical for the treatment of vascular dementia.Jan 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Food. 2016 Feb ;19(2):196-204. Epub 2015 Dec 29. PMID: 26714236

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ume (Japanese apricot)

Diseases : Brain Inflammation , Cerebral Hypoperfusion, Dementia

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

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F. mume is potentially an effective therapeutic for the treatment of vascular dementia.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 ;15:125. Epub 2015 Apr 22. PMID: 25898017

Genipin, a compound found within gardenia fruit, inhibits microglial activation in a mouse model of brain inflammation. Feb 01, 2010

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Pubmed Data : Int Immunopharmacol. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20123040

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Gardenia

Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Genistein attenuates acute cerebral ischemic damage. Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Ginkgo biloba extract has specific neuroprotective effects that may be useful for the treatment of chronic cerebral hypoperfusion.Nov 14, 2016

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Pubmed Data : Phytomedicine. 2016 Nov 15 ;23(12):1356-1364. Epub 2016 Aug 1. PMID: 27765355

Article Published Date : Nov 14, 2016

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Brain Inflammation , Cerebral Hypoperfusion

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Ginkgo biloba extract improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse.Jul 31, 2016

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Pubmed Data : Exp Gerontol. 2016 Aug ;81:92-100. Epub 2016 May 22. PMID: 27220811

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neural Regen Res. 2019 Oct ;14(10):1814-1822. PMID: 31169200

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

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Ginsenoside Rg1 may have protective effects on neuroinflammation and neuronal injury induced by chronic glucocorticoids exposure.Sep 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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High selenium yeast mitigates aluminum-induced cerebral inflammation.Jul 15, 2018

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Pubmed Data : Biometals. 2018 Jul 16. Epub 2018 Jul 16. PMID: 30014352

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Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity.Jan 05, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Shock. 2008 Feb;29(2):212-6. PMID: 17693925

Article Published Date : Feb 01, 2008

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Brain Inflammation , Heat Stroke

Pharmacological Actions : Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Long-term resveratrol treatment confers neuroprotection against cerebral vascular dysfunction during nutrient stress.Apr 08, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation.Mar 31, 2019

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Pubmed Data : J Inorg Biochem. 2019 Apr ;193:143-151. Epub 2019 Feb 1. PMID: 30743053

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Pubmed Data : Toxicology. 2014 Mar 14. Epub 2014 Mar 14. PMID: 24636977

Article Published Date : Mar 13, 2014

Study Type : Animal Study

Additional Links

Diseases : Alzheimer's Disease, Brain Inflammation , Neurotoxicity, Parkinson's Disease, Parkinsonism

Problem Substances : Glyphosate formulations, Roundup (herbicide)

Adverse Pharmacological Actions : Excitotoxic, Neurotoxic

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Melatonin attenuates sepsis induced brain injury via activation SIRT1 signaling activation.Jun 09, 2015

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Pubmed Data : J Pineal Res. 2015 Jun 10. Epub 2015 Jun 10. PMID: 26094939

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Naringenin inhibits both inflammatory pain and neurogenic inflammation.Feb 17, 2016

Nobiletin may serve as a potential approach to alleviate neuroinflammation-related diseases.May 07, 2019

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Pubmed Data : J Agric Food Chem. 2019 May 8 ;67(18):5122-5134. Epub 2019 Apr 24. PMID: 30995031

Article Published Date : May 07, 2019

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Oleocanthal and extra-virgin olive oil could provide beneficial effect to slow or halt the progression of Alzheimer's disease.Aug 20, 2019

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Pubmed Data : ACS Chem Neurosci. 2019 Aug 21 ;10(8):3543-3554. Epub 2019 Jun 25. PMID: 31244050

View the Evidence: 627 Abstracts with Brain Inflammation Research

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11.8% of 110 sudden infant death cases examined in the study occurred in temporal association with hexavalent vaccines.Mar 01, 2014

Boswellic acids could be used to reduce peritumoral edema associated with primary and secondary brain tumors.Dec 14, 2011

Despite a "decrease" in measles and mumps encephalitis, hospital admissions for encephalitis of "unknown etiology" have increased substantially.Jan 01, 2017

Extracellular vesicles are increased in the serum of children with autism spectrum disorderAug 26, 2018

Inflammation may influence glutamate metabolism to alter behaviour, leading to depressive symptoms.Nov 09, 2016

Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents.Mar 31, 2021

Lipoic acid down-regulates inflammation in multiple sclerosis patients.Jan 01, 2010

Low-grade inflammation is associated with apathy indirectly via deep white matter lesions in community-dwelling older adults.Apr 16, 2019

Mild cognitive impairment patients have higher regulatory T-cell proportions compared with Alzheimer's disease-related dementia patients.Dec 31, 2019

Milk and bacterial proteins may produce neuron-specific antigens in children with autism. Aug 01, 2002

Multi-strain probiotic supplementation seems to exert a positive effect on neuroinflammation and neurocognitive impairment in HIV-1 infected subjects.Nov 20, 2017

Neuroglial activation and neuroinflammation in the brain of patients with autism.Dec 31, 2004

Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias.Dec 15, 2017

The combined effects of yogurt and exercise in healthy adults: Implications for biomarkers of depression and cardiovascular diseases.Sep 30, 2018

The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder.May 31, 2016

The measles vaccine can induce encephalitis.Jan 19, 2017

The results suggest that aluminum-induced CRP may in part contribute to a pathophysiological state associated with a chronic systemic inflammation of the human vasculature.Jul 31, 2015

These findings suggest that predisposition to autoimmunity, and immune/inflammatory activation, may be associated with autistic regression.Dec 31, 2016

This is the first study demonstrating inflammation within the neurocircuitry of OCD.Jul 31, 2017

Women engaging in greater amounts of exercising showed lower TNF-α levels and greater dorsolateral prefrontal cortex and temporal lobe volumes.Dec 31, 2020

Mercury stimulates VEGF and IL-6 release from human mast cells which could disrupt the blood-brain-barrier and permit brain inflammation.Mar 11, 2010

This demonstrates the broad neuroprotective action of apigenin against AD pathogenesis in a human disease model.Dec 31, 2015

A case report of fatal encephalitis asssociated with the measles rubella vaccine.Dec 01, 2013

A case series of multiple sclerosis-like persistent inflammatory activity and encephalitis in the brain of hepatitis B vaccinees.Jul 22, 1999

Encephalitis with seizures in 5 patients with confirmed mumps vaccine strain in cerebrospinal fluid.Feb 15, 2015

6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment.Oct 31, 2018

6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries.Jul 14, 2020

6-Gingerol, an active constituent of ginger, attenuates lipopolysaccharide-induced oxidation, inflammation, cognitive deficits.Mar 31, 2021

6-Shogaol exerts neuroprotective effects on dopaminergic neurons in vitro and in vivo parkinson's disease models.Aug 31, 2013

6-shogaol may play a role in inhibiting glial cell activation and reducing memory impairment in animal models of dementia. Jun 19, 2014

A cecal slurry mouse model of sepsis leads to acute consumption of vitamin C in the brain.Mar 25, 2020

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.Feb 06, 2017

A Spirulina diet given to lactating mothers can protect against neuroinflammation and decreased antioxidant defence in brain of suckling pups.Aug 28, 2016

A. calamus prevented from memory deficits and stress through controlling oxidative stress and inflammation processes.Dec 31, 2017

A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-κB signaling pathway.Dec 31, 2018

Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice.Oct 06, 2019

Acupuncture is an effective treatment for chronic overlapping pain conditions and provide insight into treatment response variability.Jul 03, 2018

Acute exposure to 900-MHz microwaves induces glial reactivity and biochemical modifications in the rat brain.Dec 01, 2004

Acute neuroinflammation promotes cell responses to 1800 MHz GSM electromagnetic fields in the rat cerebral cortex.Sep 30, 2017

Addition of tart cherry to the diet may promote healthy aging or delay the onset of neurodegenerative diseases.Nov 30, 2016

Administering crocin ameliorates anxiety-like behaviors and reduces the inflammatory response in amyloid-beta induced neurotoxicity.Mar 07, 2021

Administering curcumin may alleviate cerebral inflammation resulting from intracerebral hemorrhage.Mar 25, 2016

Administration of synthetic 2-AG to mice after CHI led to significant reduction of brain oedema, better clinical recovery, reduced infarct volume and reduced hippocampal cell death compared with controls.Oct 03, 2001

Aerobic exercise significantly increases the chronic unpredictable mild stress-depressed mice hippocampus expression of miR-223.Apr 13, 2020

Alpha-mangostin reduces the overactivation of the ERK signaling and also restored autism-like behavioral and neurochemical alterations.Feb 24, 2021

Aluminium, fluoride and a combination of aluminium-fluoride treatments caused an increase in brain lipid peroxidation products and reactive oxygen species formation.Feb 28, 2015

Aluminum can induce neuroinflammation and could lead to learning and memory deficits.Apr 30, 2016

Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice .Jun 30, 2021

Antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment.Nov 27, 2017

Anti-inflammatory and anti-oxidant activity of Hidroxin in rotenone-induced Parkinson's disease.Sep 02, 2020

Anti-neuroinflammatory effect of alantolactone through the suppression of the NF-κB and MAPK signaling pathways.Jan 17, 2019

Anti-neuroinflammatory effects of a food-grade phenolic-enriched maple syrup extract in a mouse model of Alzheimer's disease.Oct 03, 2019

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone.Oct 11, 2019

Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization.Jan 07, 2020

Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice.Apr 26, 2018

Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression.Sep 29, 2020

Antidepressive effect of arctiin by attenuating neuroinflammation.Jan 04, 2020

Apigenin restored immune function and decreased neuroinflammation in an experimental autoimmune encephalomyelitis model. Jun 03, 2015

Arctigenin may have anti-inflammatory and immunosuppressive properties via inhibiting Th17 cells.Oct 05, 2015

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation.Sep 09, 2020

Artesunate may exert protective effects against cerebral ischemia/reperfusion injury.Apr 30, 2018

Ashwagandha may serve as an effective dietary supplement for management of sleep deprivation induced stress and associated functional impairments.Dec 20, 2016

Ashwagandha treatment reversed the cytoplasmic mislocalization of hTDP-43 in spinal motor neurons and in brain.Dec 06, 2016

Astaxanthin ameliorates lipopolysaccharide-induced neuroinflammation, oxidative stress and memory dysfunction.Feb 17, 2019

Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury.Sep 18, 2018

Astaxanthin attenuates neuroinflammation in status epilepticus.Dec 31, 2019

Astaxanthin exerts different anti-inflammatory effects in female and male brains.Jan 29, 2016

Astaxanthin had an anti-depressant effect on diabetic mice.Dec 21, 2016

Astaxanthin suppresses the neurological disorders induced by the K+ channel blocker kaliotoxin.Apr 05, 2016

Astragalin exerted antidepressant-like action through SIRT1 signalling modulated NLRP3 inflammasome deactivation.Jan 19, 2020

Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice.May 23, 2018

Brain Inflammation

View the Evidence:
627 Abstracts with Brain Inflammation Research