Cardiomegaly

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11 Substances Researched for Cardiomegaly

Name	AC	CK
Resveratrol	3	6
Curcumin	2	3
Cardamonin	1	2
Crocetin	1	2
Cyanidin 3-glucoside	1	2
Ginseng (American)	1	2
Paeoniflorin	1	2
Stilbenes	1	2
Tanshinone IIA	1	2
Kaempferol	1	1
P-Coumaric Acid	1	1

1 Problem Substances Researched for Cardiomegaly

Name	AC	CK	Focus
Rosiglitazone (trade name Avandia)	1	2

Research Articles 14
Cumulative Knowledge Score 22
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with Cardiomegaly Research

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[+]

Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction.Dec 31, 2017

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Pubmed Data : Pharmazie. 2018 09 1 ;73(9):508-512. PMID: 30223933

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Cardamonin

Diseases : Cardiomegaly, Myocardial Infarction

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Crocetin protects against cardiac hypertrophy. May 01, 2009

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Pubmed Data : J Cell Mol Med. 2009 May;13(5):909-25. Epub 2008 Dec 24. PMID: 19413885

Article Published Date : May 01, 2009

Study Type : Animal Study

Additional Links

Substances : Crocetin

Diseases : Cardiac Hypertrophy, Cardiomegaly

Pharmacological Actions : Antioxidants, Cardioprotective, NF-kappaB Inhibitor

[+]

Curcumin may inhibit cardiac hypertrophy and myocardial infarction.Oct 19, 2009

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Pubmed Data : Lab Invest. 2009 Oct 19. PMID: 18292806

Article Published Date : Oct 19, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cardiac Hypertrophy, Cardiomegaly, Heart Failure, Myocardial Infarction

Pharmacological Actions : Cardioprotective, Enzyme Inhibitors

[+]

Cyanidin 3-O-glucoside ameliorated cardiac hypertrophy and diastolic dysfunction in involved with hypertension.Jun 19, 2018

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Pubmed Data : Food Funct. 2018 Jun 20 ;9(6):3466-3480. PMID: 29878020

Article Published Date : Jun 19, 2018

Study Type : Animal Study

Additional Links

Substances : Cyanidin 3-glucoside

Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension

Pharmacological Actions : Cardioprotective

[+]

Ginseng may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.Nov 30, 2016

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Pubmed Data : Can J Physiol Pharmacol. 2016 Dec ;94(12):1325-1335. Epub 2016 Aug 17. PMID: 27797280

Article Published Date : Nov 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginseng (American)

Diseases : Cardiac Hypertrophy, Cardiomegaly

Pharmacological Actions : Cardioprotective

Additional Keywords : Plant Extracts

[+]

Paeoniflorin attenuates pressure overload-induced cardiac remodeling.May 31, 2013

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Pubmed Data : J Mol Histol. 2013 Jun ;44(3):357-67. Epub 2013 Feb 17. PMID: 23417833

Article Published Date : May 31, 2013

Study Type : Animal Study

Additional Links

Substances : Paeoniflorin

Diseases : Cardiomegaly, Heart Failure, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Resveratrol arrests and regresses the development of pressure overload cardiac hypertrophy in rats.May 01, 2010

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Pubmed Data : J Nutr. 2010 May;140(5):962-8. Epub 2010 Mar 24. PMID: 20335634

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Cardiac Hypertrophy, Cardiomegaly, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

Additional Keywords : Plant Extracts, Stilbenes

[+]

Resveratrol may have a beneficial effect on Ang II-induced cardiac remodeling.Jun 01, 2010

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Pubmed Data : Blood Press. 2010 Jun;19(3):196-205. PMID: 20429690

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Cardiomegaly, Hypertension, Mitochondrial Dysfunction

Additional Keywords : Mitochondrial Biogenesis, Stilbenes

[+]

Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the spontaneously hypertensive rats without lowering blood pressure.Feb 01, 2010

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Pubmed Data : Am J Hypertens. 2010 Feb;23(2):192-6. Epub 2009 Nov 26. PMID: 19942861

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol, Stilbenes

Diseases : Cardiac Hypertrophy, Cardiomegaly, Hypertension, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Rosiglitazone causes cardiac hypertrophy. Jul 01, 2009

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Pubmed Data : J Mol Cell Cardiol. 2009 Jul;47(1):85-95. Epub 2009 May 3. PMID: 19397913

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Cardiac Hypertrophy, Cardiomegaly

Problem Substances : Rosiglitazone (trade name Avandia)

Adverse Pharmacological Actions : Cardiotoxic

[+]

This study indicated a protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats.Feb 06, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Feb 7 ;8(6):10161-10170. PMID: 28053285

Article Published Date : Feb 06, 2017

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Cardiomegaly, Hypertension

Pharmacological Actions : Cardioprotective

[+]

Curcumin may play a therapeutic role in heart failure.Oct 01, 2007

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Pubmed Data : J Food Sci. 2007 Oct;72(8):S612-7. PMID: 20467147

Article Published Date : Oct 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cardiomegaly, Heart Failure

[+]

Kaempferol attenuates cardiac hypertrophy.Jun 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Planta Med. 2017 Jul ;83(10):837-845. Epub 2017 Feb 20. PMID: 28219095

Article Published Date : Jun 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Kaempferol

Diseases : Cardiomegaly, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective

[+]

Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteinsSep 30, 2013

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Pubmed Data : Food Chem Toxicol. 2013 Oct ;60:348-54. Epub 2013 May 10. PMID: 23669407

Article Published Date : Sep 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : P-Coumaric Acid

Diseases : Cardiomegaly, Myocardial Infarction

Pharmacological Actions : Cardioprotective

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 14 Abstracts with Cardiomegaly Research

Limited to Members Only

Currently Available Sorting Options

Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction.Dec 31, 2017

Crocetin protects against cardiac hypertrophy. May 01, 2009

Curcumin may inhibit cardiac hypertrophy and myocardial infarction.Oct 19, 2009

Cyanidin 3-O-glucoside ameliorated cardiac hypertrophy and diastolic dysfunction in involved with hypertension.Jun 19, 2018

Ginseng may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.Nov 30, 2016

Paeoniflorin attenuates pressure overload-induced cardiac remodeling.May 31, 2013

Resveratrol arrests and regresses the development of pressure overload cardiac hypertrophy in rats.May 01, 2010

Resveratrol may have a beneficial effect on Ang II-induced cardiac remodeling.Jun 01, 2010

Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the spontaneously hypertensive rats without lowering blood pressure.Feb 01, 2010

Rosiglitazone causes cardiac hypertrophy. Jul 01, 2009

This study indicated a protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats.Feb 06, 2017

Curcumin may play a therapeutic role in heart failure.Oct 01, 2007

Kaempferol attenuates cardiac hypertrophy.Jun 30, 2017

Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteinsSep 30, 2013

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Cardiomegaly

View the Evidence:
14 Abstracts with Cardiomegaly Research