Chemotherapy-Induced Toxicity

Name	AC	CK
Curcumin	66	113
Magnesium	10	94
Flavonoids	52	93
Ginsenosides	43	92
Thymoquinone	31	60
Vitamin E	12	49
Resveratrol	25	44
Melatonin	18	39
Alpha-Lipoic Acid	16	37
Berberine	19	37
Chokeberry	5	34
Reishi Mushroom	13	34
Bee Propolis	6	33
Ginger	13	33
Royal Jelly	12	32
Vitamin C	19	32
Homeopathic Medicine: Traumeel	2	30
NAC (N-acetyl-L-cysteine)	12	30
Nigella sativa (aka Black Seed)	16	30
Probiotics	11	30
Coenzyme Q10	11	29
Grape Seed Extract	13	28
Silibinin	6	28
Ginseng	11	27
Sulforaphane	14	25
Astragaloside	12	24
Quercetin	18	24
Rutin	14	23
Astaxanthin	12	22
Crocin	12	22
Ellagic Acid	11	22
Folic Acid	2	22
Ginkgo biloba	11	22
Citrus naringin	11	21
Hesperidin	11	21
Oleuropein	7	21
Onion	5	21
Acetyl-l-carnitine	2	20
Caffeic acid phenethyl ester	10	20
Calendula	1	20
Echinacea	6	20
Garlic	11	20
Homeopathic Medicine: All	1	20
Sodium Bicarbonate	1	20
Vitamin B-12	1	20
Wheat Grass	1	20
Chrysin	11	19
Carnitine	4	18
EGCG (Epigallocatechin gallate)	11	18
Salvia miltiorrhiza	11	18
Isoflavones	6	17
Licorice	9	17
Naringenin	9	17
Tanshinone IIA	10	17
Anthocyanins	9	16
Astragalus	5	16
L-Carnitine	4	16
Panax Notoginseng	8	16
Fucoidan	10	15
Genistein	5	15
Paeonol	8	15
Zataria multiflora	8	15
Apigenin	10	14
Cannabidiol	7	14
Green Tea	6	14
Honokiol	9	14
Neem	4	14
Pomegranate	9	14
Selenium	8	14
St. Johns Wort	3	14
Vitamin D	3	14
Angelica	3	13
Hydrogen Water	6	13
Lotus	9	13
Spirulina	6	13
Allicin	6	12
Carvacrol	6	12
Codonopsis pilosula	2	12
Ginseng (Korean)	6	12
Lactobacillus plantarum	6	12
Lycopene	7	12
Myricetin	6	12
Palmitoylethanolamide	2	12
Polyphenols	9	12
Wheat Germ	2	12
Asiatic Acid	6	11
Betulinic acid	5	11
Cannabis	2	11
Dates	6	11
Glutamine	2	11
Honey	6	11
Puerarin	5	11
Rosmarinic acid	6	11
AHCC	3	10
Bifidobacterium	1	10
Bifidobacterium Breve	1	10
Caffeine	1	10
Cordyceps sinensis	5	10
Gallic Acid	5	10
Geranium	1	10
Honey: Life Mel Proprietary Formula	1	10
Luteolin	7	10
Mangosteen	3	10
Medicinal Mushrooms	5	10
Multivitamin	1	10
Olive leaf extract	5	10
Paeoniflorin	7	10
Saccharomyces Boulardii	1	10
Saffron	4	10
Sea buckthorn	6	10
Vitamin B-6	1	10
Chrysanthemum Indicum	3	9
Fisetin	4	9
Gingerol	5	9
Maitake Mushroom	4	9
Poria cocos	5	9
Sesamol	6	9
Urolithin A	5	9
Beta-glucan	3	8
Camel Milk	4	8
Diosmin	4	8
Emodin	6	8
Flaxseed	4	8
Geraniol	4	8
Honeysuckle	4	8
Lactobacillus rhamnosus	4	8
P-Coumaric Acid	5	8
Panax Ginseng	4	8
Phloretin	5	8
Seaweed: Brown	4	8
Andrographis	6	7
Baicalein	3	7
Carotenoids	4	7
Crocetin	2	7
Fermented Foods and Beverages	4	7
Ferulic acid	6	7
Indole-3-Carbinol	4	7
Mangiferin	4	7
Piperine	4	7
Rose	4	7
Rosemaric Acid	5	7
Schisandra	3	7
Tannic Acid	4	7
Arginine	3	6
Bael	3	6
Beta-Caryophyllene	3	6
Betanin	3	6
Black Tea	4	6
Cannabinoids	4	6
Diosgenin	3	6
Fig	3	6
Frankincense	3	6
Grape	4	6
Huaier (Trametes robiniophila murr)	3	6
Icariin	3	6
Lactobacillus Acidophilus	3	6
Nobiletin	3	6
Oligosaccharides	3	6
Omega-3 Fatty Acids	3	6
Orange	3	6
Patchouli	3	6
Pomegranate Seed	2	6
Pterostilbene	3	6
Punicalagin	4	6
Pycnogenol (Pine Bark)	3	6
Red Sage	3	6
Rhubarb	3	6
Safflower	3	6
Taurine	3	6
White Tea	3	6
Aloe Vera	3	5
Blueberry	3	5
Chlorella (Algae)	2	5
Citrus Triterpenoids	3	5
Cordyceps Militaris	3	5
Gold (nanoparticles)	3	5
Gotu Kola	3	5
Kaempferol	3	5
Ligustrazine	3	5
Olive Oil	3	5
Peony	3	5
Soy	1	5
Vitamin E: alpha tocopherol	3	5
Wogonin	3	5
18β-Glycyrrhetinic Acid	2	4
Amla Fruit	2	4
Apocynin	2	4
Bacopa	2	4
Bai Zhu	2	4
Barberry	2	4
Bile salts	1	4
Bitter Apple	2	4
Blackberry	2	4
Capsaicin	2	4
Carnosic Acid	2	4
Cashew	2	4
Celery	2	4
Celery Oil	2	4
Citrus Peel	2	4
Clove	2	4
Coconut Oil	2	4
Curcuminoids	2	4
Delta-tetrahydrocannabinol (THC)	2	4
Diallyl sulfide	2	4
Eugenol	2	4
Evening Primrose Oil	2	4
Fenugreek	2	4
Garcinia kola	2	4
Garlic: Aged	2	4
Ginseng (American)	2	4
Hawthorn	2	4
Hazelnut	2	4
Lactobacillus paracasei	2	4
Lactoferrin	2	4
Lemon Peel	1	4
Lion's Mane (Hericium Erinaceus)	2	4
Magnolol	2	4
Mango	2	4
Manuka Honey	2	4
Milk Thistle	2	4
Moringa oleifera	2	4
Nordihydroguaiaretic acid (NDGA)	2	4
Oleanolic acid	2	4
Oyster Mushroom	2	4
Parsley	2	4
Piceatannol	3	4
Piperidines	1	4
Plantago	2	4
Pomegranate Peel	2	4
Pumpkin Seeds	2	4
Red Wine Extract	1	4
Rubia Cordifolia	1	4
Sesamin	2	4
Silymarin	2	4
Soup	2	4
Spikenard	2	4
Tangeretin	3	4
Terminalia	2	4
Testosterone	1	4
Theanine	2	4
Vanillin	2	4
Vitexins	2	4
Walnut	2	4
White Mulberry	3	4
Achiote	2	3
Andrographolide	2	3
Bee Venom	2	3
Bromelain	2	3
Carbon 60	2	3
Daidzein	2	3
Dandelion	1	3
Diosmetin	1	3
Eriodictyol	2	3
Formononetin	2	3
Goji	2	3
Pine Bark Extract	2	3
Riboflavin (Vitamin B-2)	2	3
Rosemary	2	3
Thunder god vine	1	3
Watercress	2	3
Xanthohumol	2	3
Acorus calamus	1	2
Apricot Kernel	1	2
Arctigenin	1	2
Artemisinin	1	2
Artesunate	1	2
Ashwagandha	1	2
Avocado	1	2
Basil	1	2
Bee Pollen	1	2
Bergamot	1	2
Betaine	1	2
Bifidobacterium Bifidum	1	2
Bifidobacterium Lactis	1	2
Bilberry	1	2
Biochanin A	1	2
Bisdemethoxycurcumin	2	2
Bitter Melon	1	2
Bitter Orange	1	2
Bixin	2	2
Boerhaavia diffusa	1	2
Buckwheat	1	2
Butterfly Pea	1	2
Cannabigerol	1	2
Carrot	1	2
Carrots	1	2
Catechols	1	2
Chickpea	1	2
Chicoric Acid	1	2
Chlorogenic Acid	1	2
Cinnamaldehyde	1	2
Cinnamic acid	1	2
Coconut	1	2
Coconut Husk/Fiber	1	2
Coriandrum sativum	1	2
Corn Silk	1	2
Corn: Purple	1	2
Curcuma Comosa	1	2
Curry Leaves	1	2
Cyanidin 3-glucoside	1	2
D-Limonene	1	2
Dogwood	1	2
Dragon Fruit	1	2
Eucalyptus	1	2
Fucoxanthin	1	2
Glycyrrhizin	1	2
Grapes	1	2
Guava	1	2
Guduchi	1	2
Harmine	1	2
Hemp Seed	1	2
Hibiscus sabdariffa	1	2
Homeopathic Arsenicum album	1	2
Horehound	1	2
Horsetail	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrangea	1	2
Hydrogen: Molecular	1	2
Indian Mulberry	1	2
Ipriflavone	1	2
Jujube	2	2
Kahweol	1	2
Kefir	1	2
Kimchi	1	2
Kombucha Tea	1	2
Lactobacillus casei	1	2
Lactobacillus reuteri	1	2
Lecithin	1	2
Lemon	1	2
Liquiritigenin	1	2
Long Pepper	1	2
Loquat Seeds	1	2
Lutein	1	2
Lychee	1	2
Magnesium Sulfate	1	2
Marjoram	1	2
Meadowsweet	1	2
Methionine	1	2
Modified Citrus Pectin	1	2
Mushrooms: All	1	2
Mustard Greens	1	2
Nettle	1	2
Noni	1	2
Okra	1	2
Orange: Mandarin	1	2
Organosulfur Compounds	1	2
Orthosiphon	1	2
Passion fruit	1	2
Pea	1	2
Phlorotannins	1	2
Plantago major	1	2
Prickly Pear Cactus	1	2
Procyanidin B2	1	2
Propolis: Bee	1	2
Purslane	1	2
Quince	1	2
Raspberry	1	2
Raspberry ketone	1	2
Rehmannia	2	2
Rooibos	2	2
Saikosaponin	1	2
Sandalwood	1	2
Sea Cucumber	1	2
Seaweed	1	2
Sesame Seeds	1	2
Silver (nanoparticles)	1	2
Stilbenes	1	2
Strawberry	1	2
Sumac	1	2
Superoxide dismutase	1	2
Sweet Potato: Purple	1	2
Tetrahydrocurcumin	1	2
Thiamine (B-1)	1	2
Thyme	1	2
Thymol	1	2
Tocotrienol: Delta	2	2
Trichosanthes Kirilowii	1	2
Turmeric	1	2
Turmeric: Fermented	1	2
Ursolic Acid	1	2
Vinpocetine	1	2
Vitamin E: Gamma-Tocopherol	1	2
Water: Deep Sea	2	2
Water: Deuterium Depleted	1	2
Watermelon	1	2
Whey	1	2
Woodfordia fruticosa	1	2
Yarrow	1	2
Zinc	1	2
Acai	1	1
Alpha Linolenic Acid	1	1
Amygdalin	1	1
Antrodia cinnamomea	1	1
Beet	1	1
Benzyl isothiocyanate	1	1
Caffeic Acid	1	1
Camu Camu	1	1
Capparis spinosa (caper)	1	1
Catechin	1	1
Celastrol	1	1
Cysteine (see N-Acetylcysteine)	1	1
Eggplant	1	1
Genipin	1	1
Gold	1	1
Hydroxytyrosol	1	1
Hyperforin	1	1
Isoliquiritigenin	1	1
Isothiocyanate	1	1
Lettuce	1	1
Marijuana	1	1
Persimmon	1	1
Phyllanthus urinaria	1	1
Pumpkin	1	1
Rice Bran	1	1
Soursop	1	1
Sweet Orange	1	1
Tocotrienols	1	1
Zerumbone	1	1

Name	AC	CK
Cisplatin	14	42
Cyclophosphamide	17	36
Chemotherapy	2	22
Arsenic Trioxide	9	17
Doxorubicin	7	13
Paclitaxel	5	12
Atorvastatin	1	10
Dl-alpha-tocopherol acetate	1	10
Tamoxifen	1	10
Bleomycin	3	9
Fluorouracil (5-FU or f5U)	3	5
Nicotine	3	3
Acetaminophen	1	2
Monosodium Glutamate (MSG)	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Paracetamol	1	2
Benzo(a)pyrene	1	1
Bisphenol A	1	1
Cadmium	1	1
Cyclosporins	1	1
Isoproterenol	1	1
Methotrexate	1	1
Streptozotocin	1	1

Name	AC	CK
Cryotherapy	3	31
Exercise	4	26
Infrared Light	1	20
Light Therapy: Red Colored	1	20
Laser Treatment: Low-Level	4	15
Dietary Modification: Mediterranean Diet	1	10
Fasting/Caloric Restriction	1	10
Homeopathic Treatment	1	10
Hyperbaric Treatment	2	5
Electroacupuncture	2	4
Dietary Modification: Low Calorie Diet	1	2
Exercise: Aerobic	1	2
Light-Emitting Diodes (LEDs) Therapy	1	2
Microbiota Transfer Therapy	1	2
Traditional Chinese Medicine	1	2
Guided Imagery	1	1
Laser Treatment	1	1
Ozone Therapy	1	1
Thermal Therapy: Far-Infrared	1	1

Name	AC	CK
Chemotherapy	11	71
Radiotherapy	2	12
Electromagnetic Field Harms	1	1
Electromagnetic Radiation	1	1

Click here to read the entire abstract

Pubmed Data : Int J Clin Oncol. 2020 Aug 1. Epub 2020 Aug 1. PMID: 32740717

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer

Pharmacological Actions : Chemoprotective Agents

[+]

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicityDec 12, 2016

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Pubmed Data : Support Care Cancer. 2016 Dec 13. Epub 2016 Dec 13. PMID: 27966021

Pubmed Data : Support Care Cancer. 2010 Jun;18(6):751-9. Epub 2009 Aug 14. PMID: 19685085

Article Published Date : Jun 01, 2010

Study Type : Human Study

Additional Links

Substances : Bifidobacterium, Bifidobacterium Breve, Probiotics

Diseases : Chemotherapy-Induced Toxicity

[+]

Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.Dec 01, 2008

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Pubmed Data : Exp Neurol. 2008 Dec;214(2):276-84. Epub 2008 Sep 9. PMID: 18809400

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy

Pharmacological Actions : Neuroprotective Agents

[+]

An intravenous hydration regimen supplemented with magnesium prevented cisplatin-induced nephrotoxicity in patients with head and neck cancer.Feb 01, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Otolaryngol Head Neck Surg. 2018 Feb 2 ;47(1):10. Epub 2018 Feb 2. PMID: 29394952

[+]

Dl-alpha-tocopherol acetate does not protect against chemotherapy-induced chromosome damage and reduces the level of plasma gamma tocopherol.Feb 01, 2002

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Pubmed Data : Melanoma Res. 2002 Feb;12(1):83-90. PMID: 11828262

Article Published Date : Feb 01, 2002

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Melanoma

Problem Substances : Dl-alpha-tocopherol acetate

[+]

Effects of photobiomodulation (660 nm laser) on anthracycline extravasation.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Rev Lat Am Enfermagem. 2022 ;30:e3693. Epub 2022 Oct 17. PMID: 36287401

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pharmacol Toxicol. 2014 ;15:70. Epub 2014 Dec 4. PMID: 25472655

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer

Pharmacological Actions : Chemoprotective Agents, Renoprotective

Additional Keywords : Significant Treatment Outcome, Supplementation

[+]

Intravenous magnesium supplementation conferred protective effects against cisplatin-induced nephrotoxicity.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(17):7517-22. PMID: 26625755

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Onion

Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic

Additional Keywords : Dietary Modification

[+]

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.Sep 01, 2011

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Pubmed Data : J Psychosoc Oncol. 2011 Sep-Oct;29(5):499-514. PMID: 21882931

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Pubmed Data : CNS Neurol Disord Drug Targets. 2011 Dec ;10(8):916-20. PMID: 22229320

Article Published Date : Nov 30, 2011

Study Type : Human Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Chemotherapy-Induced Toxicity, Multiple Myeloma

Pharmacological Actions : Chemoprotective Agents

[+]

Photobiomodulation therapy prevents dysgeusia chemotherapy induced in breast cancer women treated with doxorubicin plus cyclophosphamide.Feb 28, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Med Food. 2005 Fall;8(3):382-5. PMID: 3857944

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukemia: Acute myelogenous leukemia (AML) , Lymphoma, Myelodysplastic Syndrome, Radiation Induced Illness

Additional Keywords : Iatrogenic Disease

Anti Therapeutic Actions : Chemotherapy, Radiotherapy

[+]

These results demonstrated the feasibility of a dietary antioxidant supplementation in order to prevent the cisplatin induced hearing damage.Jan 31, 2017

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Pubmed Data : Heliyon. 2017 Feb ;3(2):e00251. Epub 2017 Feb 20. PMID: 28239674

Article Published Date : Jan 31, 2017

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Multivitamin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents

[+]

TRAUMEEL S may reduce significantly the severity and duration of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.Aug 01, 2001

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Pubmed Data : Cancer. 2001 Aug 1;92(3):684-90. PMID: 11505416

Article Published Date : Aug 01, 2001

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Pubmed Data : Int J Environ Res Public Health. 2016 ;13(2). Epub 2016 Feb 19. PMID: 26907305

Article Published Date : Dec 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Onion

Diseases : Chemotherapy-Induced Toxicity: Bleomycin

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Plant Extracts

Problem Substances : Bleomycin

[+]

Protective effects of crocetin on arsenic trioxide-induced oxidative stress.Oct 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2021 Nov-Dec;35(6):3157-3163. PMID: 34697146

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Pubmed Data : Phytomedicine. 2023 Jul ;115:154776. Epub 2023 Mar 18. PMID: 37087793

Article Published Date : Jun 30, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemoprotective Agents

[+]

Hydrogen-rich saline attenuates cardiac and hepatic injury in a doxorubicin model.Dec 31, 2015

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Puerarin activates adaptive autophagy and protects the myocardium against doxorubicin-induced cardiotoxicity.Aug 31, 2022

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Pubmed Data : Biomed Pharmacother. 2022 Sep ;153:113403. Epub 2022 Jul 13. PMID: 36076529

Article Published Date : Aug 31, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

Solubilized curcuminoid complex prevents extensive immunosuppression through immune restoration and antioxidant activity.Dec 25, 2022

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"Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy."Feb 14, 2012

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Pubmed Data : Clin Cancer Res. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22338017

Article Published Date : Feb 14, 2012

Pubmed Data : Clin Exp Pharmacol Physiol. 2016 Apr 30. Epub 2016 Apr 30. PMID: 27130783

Article Published Date : Apr 29, 2016

Study Type : Animal Study

Additional Links

Diseases : Anorexia: Cancer-Associated, Cachexia: Chemotherapy Induced, Chemotherapy-Induced Toxicity: 5-fluorouracil

Problem Substances : Fluorouracil (5-FU or f5U)

[+]

6-gingerol ameliorates cisplatin-induced pica.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2020 ;14:4085-4099. Epub 2020 Oct 2. PMID: 33061309

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents

[+]

6-gingerol was as effective as ondansetron in the treatment of pica induced by cisplatin.Dec 31, 2018

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Pubmed Data : Indian J Pharmacol. 2017 Jan-Feb;49(1):65-70. PMID: 28458425

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

A combination of virgin coconut oil and extra virgin olive oil elicits superior protection against doxorubicin cardiotoxicity in rats.Jan 28, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Turk J Pharm Sci. 2022 04 29 ;19(2):138-144. PMID: 35509244

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2014 ;14(1):92. Epub 2014 Sep 28. PMID: 25298749

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Renoprotective

Additional Keywords : Plant Extracts

[+]

Aged garlic extract and grape seed proanthocyanidin protect against doxorubicin-induced cardiotoxicity.Aug 01, 2009

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Pubmed Data : Can J Physiol Pharmacol. 2009 Aug;87(8):633-40. PMID: 19767888

Pubmed Data : Food Chem Toxicol. 2023 Nov ;181:114090. Epub 2023 Oct 12. PMID: 37838213

Article Published Date : Oct 31, 2023

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

Ameliorating effects of Hericium erinaceus polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide.Mar 19, 2023

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Pubmed Data : Food Funct. 2023 Mar 20 ;14(6):2921-2932. Epub 2023 Mar 20. PMID: 36892225

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Pubmed Data : Pharm Biol. 2023 Dec ;61(1):1211-1221. PMID: 37585723

Article Published Date : Nov 30, 2023

Study Type : Animal Study

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Substances : Chicoric Acid, Echinacea

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Immunomodulatory

Additional Keywords : Plant Extracts

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An extract of Mandarin Orange demonstrates anti-pulmonary fibrosis effects. Oct 29, 2009

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Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):143-8. Epub 2009 Jul 28. PMID: 19643175

Article Published Date : Oct 29, 2009

Study Type : Animal Study

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Substances : Orange: Mandarin

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis

[+]

An extract of Moringa oleifera leaves could protect the spermatogonial cells from cyclophosphamide induced damage.Apr 21, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Apr 22 ;182:101-9. Epub 2016 Feb 10. PMID: 26875643

Article Published Date : Apr 21, 2016

Study Type : Animal Study

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Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Fertility Agents: Male

Additional Keywords : Plant Extracts

Problem Substances : Cyclophosphamide

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An extract of P. oleracea leaves ameliorated the immunosuppressive action of cyclophosphamide in mice.Apr 05, 2018

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Pubmed Data : J Ethnopharmacol. 2018 Apr 6 ;215:191-198. Epub 2018 Jan 9. PMID: 29325915

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Pubmed Data : Food Chem Toxicol. 2014 Mar ;65:140-6. Epub 2013 Dec 31. PMID: 24389340

Article Published Date : Feb 28, 2014

Study Type : Animal Study

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Substances : Ipriflavone

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage

Pharmacological Actions : Antimutagenic Agents, Chemoprotective Agents

[+]

Antioxidant and anti-inflammatory effects of crocin ameliorate doxorubicin-induced nephrotoxicity.Dec 31, 2020

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Apigenin-coated gold nanoparticles as a cardioprotective strategy against doxorubicin-induced cardiotoxicity.Feb 28, 2023

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Pharmacological Actions : Chemoprotective Agents, MicroRNA modulator

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Astragaloside IV attenuates the myocardial injury caused by adriamycin by inhibiting autophagy.Dec 31, 2020

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Pubmed Data : Biochem Pharmacol. 2020 Oct 24 ;183:114299. Epub 2020 Oct 24. PMID: 33148504

Article Published Date : Oct 23, 2020

Study Type : Animal Study

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Substances : Astragaloside

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Renoprotective

[+]

Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury.Jan 27, 2020

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Pubmed Data : J Ethnopharmacol. 2020 Jan 28 ;252:112637. Epub 2020 Jan 28. PMID: 32004631

Article Published Date : Jan 27, 2020

Study Type : Animal Study

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Substances : Astragalus, Panax Notoginseng

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Bacopa monnieri may be useful alone or in combination with other anti-emetic drugs for the treatment of chemotherapy-induced emesis in man.Mar 31, 2017

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Pubmed Data : Front Pharmacol. 2021 ;12:758670. Epub 2021 Oct 13. PMID: 34721041

Bilberry enhances the effects and reduces the side effects of the chemotoxic agaent 5-flouroucil.Jan 01, 2007

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Pubmed Data : Biofactors. 2007;29(1):55-65. PMID: 17611294

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Pubmed Data : J Complement Integr Med. 2017 Dec 13. Epub 2017 Dec 13. PMID: 29236674

Article Published Date : Dec 12, 2017

Study Type : Animal Study

Additional Links

Substances : Bitter Apple

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, Renoprotective

[+]

Bitter apple pretreatment attenuates cyclophosphamide-induced oxidative stress and the subsequent DNA damage in mice.Dec 31, 2012

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Pubmed Data : ScientificWorldJournal. 2013 ;2013:980480. Epub 2013 Nov 7. PMID: 24324391

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Pubmed Data : ACS Omega. 2022 Apr 26 ;7(16):13697-13703. Epub 2022 Apr 14. PMID: 35559194

Article Published Date : Apr 25, 2022

Study Type : Animal Study

Additional Links

Substances : Frankincense

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

Brassica rapa (Mustard Greens) have a protective effect on cisplatin-induced nephrotoxicity in cells and rats. Dec 01, 2006

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Pubmed Data : Biol Pharm Bull. 2006 Dec;29(12):2436-41. PMID: 17142978

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:8424872. Epub 2019 Jul 29. PMID: 31467580

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation

Additional Keywords : C-phycocyanin

[+]

C. indicum ethanol extract could attenuate cisplatin-induced nephrotoxicity and might be a beneficial agent for acute renal failure management.Feb 28, 2015

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Pubmed Data : Nat Prod Commun. 2015 Mar ;10(3):397-402. PMID: 25924514

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Pubmed Data : Front Cardiovasc Med. 2022 ;9:695004. Epub 2022 Jul 5. PMID: 35865382

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Paeonol

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Heart Failure

Pharmacological Actions : Cardioprotective, Chemoprotective Agents, MicroRNA modulator

[+]

Cardioprotective effect of Rheum turkestanicum against doxorubicin-induced toxicity.Dec 31, 2021

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Pubmed Data : J Med Food. 2017 Oct ;20(10):944-950. Epub 2017 Aug 17. PMID: 28816580

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Pubmed Data : Can J Physiol Pharmacol. 2017 Feb 3. Epub 2017 Feb 3. PMID: 28177660

Article Published Date : Feb 02, 2017

Study Type : Animal Study

Additional Links

Substances : Carvacrol

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Renoprotective

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Ginsenoside Rg3 for chemotherapy-induced myelosuppression.Dec 31, 2019

There are high rates of behavioral symptoms in breast cancer survivors, particularly those treated with chemotherapyAug 08, 2011

There is evidence to support the use of topical calendula for prophylaxis of acute dermatitis during radiotherapy and Traumeel S mouthwash in the treatment of chemotherapy-induced stomatitis. Jan 01, 2009

These results highlight the potential protective effect of magnesium supplementation on cisplatin-induced acute nephrotoxicity.Aug 18, 2019

A combination of geranium extract, Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis, improve the condition of cancer patients receiving chemotherapy/radiotherapy. Jun 01, 2009

A proprietary honey-based herbal formula reduces chemotherapy-induced neutropenia and the need for colony-stimulating factors.Jan 01, 2006

A short hydration regimen with 20 mEq of magnesium supplementation is safe and feasible for patients with lung cancer receiving cisplatin-based chemotherapy.Jul 31, 2020

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicityDec 12, 2016

A. melanocarpa may be regarded as a promising new source of bioactive antioxidant natural compounds for breast cancer patients.Feb 28, 2013

Acetyl L-carnitine treatment improves symptoms of chemotherapy induced neuropathy. Aug 01, 2005

Acetyl-L-carnitine appears to be an effective and well-tolerated agent for the treatment of chemotherapy-induced peripheral neuropathy.Mar 01, 2005

Acute exercise protects against doxorubicin cardiotoxicity.Sep 01, 2008

Adjunctive oral cryotherapy is effective for the prophylaxis and relief of oral mucositis and anorexia caused by chemotherapy.Dec 31, 2018

Administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies improves their intestinal environments.Jun 01, 2010

Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.Dec 01, 2008

An intravenous hydration regimen supplemented with magnesium prevented cisplatin-induced nephrotoxicity in patients with head and neck cancer.Feb 01, 2018

Astragalus may provide an ideal complementary treatment to chemotherapy.Mar 01, 2008

Atorvastatin causes cardiomyopathy when administered in combination with chemotherapy.Jul 01, 2007

Bee honey and royal jelly are effective in reducing cisplatin nephrotoxicity.May 25, 2017

Bi-weekly administration of paclitaxel and cisplatin in patients with advanced esophageal cancer results in amedian survival for all patients of 9 months.Mar 04, 2002

Caffeine potentiates chemotherapy for metastatic osteosarcoma.Sep 01, 2009

Cannabis extract is safe and efficacious in reducing chemotherapy-induced nauseau and vomiting.Nov 01, 2010

Carnitine improves fatigue, quality of life, lean body mass and appetite in advanced cancer patients undergoing anticancer therapy. Feb 01, 2006

Chemotherapy used in advanced gastric or gastroesophageal adenocarcinoma results in an overall median survival time of between 7-9 months.Mar 20, 2010

Children treated for solid tumors or lymphoma with chemotherapy have increased caries of the primary teeth.Jan 01, 2010

Cisplatin-associated severe acute kidney injury occurs in 20% of the patients and has a negative impact on long-term renal function and patient survival.Dec 31, 2014

Dl-alpha-tocopherol acetate does not protect against chemotherapy-induced chromosome damage and reduces the level of plasma gamma tocopherol.Feb 01, 2002

Effects of photobiomodulation (660 nm laser) on anthracycline extravasation.Dec 31, 2021

Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction.Oct 05, 2006

Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric patients.Oct 01, 2004

Ginger root powder is effective in reducing severity of acute and delayed chemotherapy-induced nausea and vomiting as additional therapy to ondensetron and dexamethasone in patients receiving chemotherapy.Sep 14, 2010

High-volume hydration and magnesium supplementation can reduce the renal toxicity induced by cisplatin.Dec 31, 2013

Intravenous magnesium supplementation conferred protective effects against cisplatin-induced nephrotoxicity.Dec 31, 2017

L-carnitine could enhance the spermatogenesis process after exposure to cisplatin during the prepubertal phase.Aug 08, 2020

Magnesium supplementation during cisplatin-containing chemotherapy was associated with less cisplatin-induced nephrotoxicity.Apr 19, 2018

Magnesium was found to provide nephroprotective effects among patients with cervical cancer undergoing chemotherapy with cisplatin alone.Mar 31, 2015

Manipulation of diet through high intake of yellow onion is a promising possibly to improve the synergistic effect in DOX-based chemotherapy.Dec 31, 2014

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.Sep 01, 2011

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Oral cryotherapy prevents oral mucositis and pain among patients with colorectal cancer undergoing chemotherapy.Dec 31, 2017

Oral glutamine supplementation protects lymphocytes and attenuates gut permeability in patients with esophageal cancer during radiochemotherapy.Apr 01, 1998

Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients.Apr 15, 2021

Our results suggest that the Aronia extract supplementation in breast cancer patients has a beneficial effect on thiols concentration in plasma. Dec 31, 2012

Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy.Nov 30, 2011

Photobiomodulation therapy prevents dysgeusia chemotherapy induced in breast cancer women treated with doxorubicin plus cyclophosphamide.Feb 28, 2022

Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy.Mar 01, 2002

Propolis plus bicarbonate was safe, well tolerated and promisingly effective in the prevention of oral mucositis in patients with breast cancer.Oct 31, 2017

Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer.Aug 16, 2022

Pyridoxine is effective for preventing hand-foot syndrome induced by pegylated liposomal doxorubicin.Dec 31, 2021

Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies.Dec 23, 2019

Saccharomyces boulardii has significant therapeutic activity in irinotecan-induced (chemotherapy) diarrhea and mucositis.Dec 09, 2008

Short term fasting during chemotherapy was well tolerated and reduced hematological toxicity of TAC in HER2-negative BC patients.Oct 04, 2015

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Soy isoflavones ameliorate the adverse effects of chemotherapy in children.Oct 01, 1996

The cisplatin total dose had a significant negative relationship with magnesium levels at 12 months in this study. Jul 31, 2015

The decrease in neutrophil count caused by breast carcinoma chemotherapy was ameliorated by dietary supplementation with a multivitamin or vitamin E.Sep 01, 2004

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

These results demonstrated the feasibility of a dietary antioxidant supplementation in order to prevent the cisplatin induced hearing damage.Jan 31, 2017

TRAUMEEL S may reduce significantly the severity and duration of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.Aug 01, 2001

Vitamin E and N-acetylcysteine are an effective antioxidant adjuvant therapy in children with acute lymphoblastic leukemia to reduce the chemo-/radiotherapy toxicity of treatment. Jan 01, 2009

Wheat grass juice may reduce myelotoxicity and need for granulocyte colony-stimulating factors in breast cancer patients receiving chemotherapy.Jan 01, 2007

Glycine max and Chrysanthemum indicum extracts exhibited a promising protective effect on cisplatin-induced nephrotoxicity.Nov 30, 2011

Onion extract may have protective effects against BLM-induced cyto- and genotoxicity in human lymphocytes.Dec 31, 2015

Protective effects of crocetin on arsenic trioxide-induced oxidative stress.Oct 31, 2021

Self-assembled betulinic acid can be used to ameliorate the cytotoxic effects of Doxorubicin.Apr 30, 2015

These findings indicate that the protective effects of low-dose BBR against DOX-induced cardiotoxicity are mediated by Bcl-xL.Apr 29, 2022

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

Baicalein enhances the expansion of hematopoietic and progenitor stem cells and alleviates 5-fluorouracil-induced myelosuppression.Feb 02, 2023

Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.Nov 17, 2022

Chlorella sorokiniana extract prevents cisplatin-induced myelotoxicity.Dec 31, 2019

Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis.Apr 30, 2022

Chemotherapy-Induced Toxicity

View the Evidence:
1384 Abstracts with Chemotherapy-Induced Toxicity Research