Chronic Pain

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21 Substances Researched for Chronic Pain
NameACCKFocus
Turmeric221Locked
Curcuminoids120Locked
Ginger120Locked
Cannabis413Locked
Delta-tetrahydrocannabinol (THC)211Locked
Curcumin110Locked
Vitamin D110Locked
Cannabinoids 55Locked
Kratom23Locked
Bacopa12Locked
Dill12Locked
Feverfew12Locked
Psychedelics:All 12Locked
Resveratrol12Locked
Anandamide11Locked
Cannabidiol 11Locked
Endocannabinoids11Locked
Garlic11Locked
Melatonin11Locked
Mineral Water11Locked
Willow Bark11Locked
3 Problem Substances Researched for Chronic Pain
NameACCKFocus
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)120Locked
Morphine110Locked
Sertraline12Locked
18 Therapeutic Actions Researched for Chronic Pain
NameACCKFocus
Tai Chi120Locked
Mud therapy 312Locked
Bath: Sulfur110Locked
Cognitive Behavioural Approaches110Locked
Emotional Freedom Technique110Locked
Floatation Tank Immersion110Locked
Integrative Medicine110Locked
Meditation 110Locked
Music110Locked
Reiki Therapy110Locked
Relaxation Therapy 110Locked
Shinrin-yoku (taking in the atmosphere of the forest)110Locked
Acupuncture13Locked
Hydrotherapy 22Locked
Balneotherapy11Locked
Fasting/Caloric Restriction11Locked
Sauna Therapy11Locked
Spa Bathing11Locked

View the Evidence:
115 Abstracts with Chronic Pain Research

[+]

Acupuncture and conventional medicine for chronic neck pain have similar effectiveness on pain and disability.Nov 08, 2017

Pubmed Data : Am J Chin Med. 2017 Nov 9:1-23. Epub 2017 Nov 9. PMID: 29121797
Article Published Date : Nov 08, 2017
Study Type : Meta Analysis
Additional Links
Diseases : Chronic Pain, Neck Pain
Therapeutic Actions : Acupuncture, Electroacupuncture
Pharmacological Actions : Analgesics
[+]

Acupuncture may be effective at relieving chronic knee pain.Nov 07, 2017

Pubmed Data : Acupunct Med. 2017 Nov 8. Epub 2017 Nov 8. PMID: 29117967
Article Published Date : Nov 07, 2017
Study Type : Meta Analysis
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Acupuncture
[+]

Clinicians may consider Tai Chi as a viable complementary and alternative medicine for chronic pain conditions.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:25325. Epub 2016 Apr 29. PMID: 27125299
Article Published Date : Dec 31, 2015
Study Type : Meta Analysis, Review
Additional Links
Diseases : Chronic Pain, Osteoarthritis, Pain: Lower Back
Therapeutic Actions : Tai Chi
Pharmacological Actions : Analgesics
[+]

Curcuminoids supplements may be a safe and effective strategy to improve pain severity.Dec 13, 2015

Pubmed Data : Pain Med. 2015 Dec 14. Epub 2015 Dec 14. PMID: 26814259
Article Published Date : Dec 13, 2015
Study Type : Meta Analysis, Review
Additional Links
Substances : Curcuminoids
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Ear acupuncture may be a promising modality to be used for pain reduction within 48 hours.Feb 28, 2017

Pubmed Data : Pain Med. 2017 Mar 1 ;18(3):551-564. PMID: 28395101
Article Published Date : Feb 28, 2017
Study Type : Meta Analysis, Review
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Acupuncture
Pharmacological Actions : Analgesics
[+]

Palmitoylethanolamide may be a useful treatment for pain and is generally well tolerated in research populations.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Physician. 2017 Jul ;20(5):353-362. PMID: 28727699
Article Published Date : Jun 30, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

The current meta-analysis supports the use of melatonin for anti-nociception.Nov 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 21 ;8(59):100582-100592. Epub 2017 Oct 5. PMID: 29246003
Article Published Date : Nov 20, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : Melatonin
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive , Brain-derived neurotrophic factor modulator
Additional Keywords : Antinoceceptive, Brain-derived neurotrophic factor modulator, Chronic Pain, melatonin
[+]

The findings of meta-analysis indicate that laser phototherapy is highly effective for pain relief.Mar 26, 2018

Pubmed Data : Photomed Laser Surg. 2018 Mar 27. Epub 2018 Mar 27. PMID: 29583080
Article Published Date : Mar 26, 2018
Study Type : Meta Analysis
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Laser Treatment , Light Therapy
Pharmacological Actions : Analgesics
[+]

Zingiberaceae extracts are clinically effective hypoalgesic agents and the available data show a better safety profile than non steroidal anti inflammatory drugs.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr J. 2015 ;14:50. Epub 2015 May 14. PMID: 25972154
Article Published Date : Dec 31, 2014
Study Type : Meta Analysis, Review
Additional Links
Substances : Ginger, Turmeric
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

A combination of multidisciplinary treatment and repeated thermal therapy may be a promising method for treatment of chronic pain.Dec 31, 2004

Pubmed Data : Psychother Psychosom. 2005 ;74(5):288-94. PMID: 16088266
Article Published Date : Dec 31, 2004
Study Type : Human Study
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Thermal Therapy: Far-Infrared
[+]

A curcumin extract is appropriate for the care of patients with joint problems and may also contribute to the regeneration of cartilage.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Rheumatol J. 2014 ;8:77-81. Epub 2014 Oct 17. PMID: 25352926
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Chronic Pain, Osteoarthritis, Quality of Life: Poor
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

A fenugreek transdermal patch decreases pain score and demand for morphine in post-surgery patients in comparison to diclofenac patch.Feb 04, 2019

Pubmed Data : J Complement Integr Med. 2019 Feb 5. Epub 2019 Feb 5. PMID: 30721143
Article Published Date : Feb 04, 2019
Study Type : Human Study
Additional Links
Substances : Fenugreek
Diseases : Chronic Pain, Postoperative Recovery
Pharmacological Actions : Antinoceceptive
Additional Keywords : Medication Reduction
[+]

Acupuncture therapy offered in the group setting was effective in reducing pain severity.Jun 07, 2017

Pubmed Data : Pain Med. 2017 Jun 8. Epub 2017 Jun 8. PMID: 28595273
Article Published Date : Jun 07, 2017
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Osteoarthritis
Therapeutic Actions : Acupuncture
Pharmacological Actions : Analgesics
[+]

Application of diosmin might be able to reduce radicular pain.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2017 ;2017:6875968. Epub 2017 Oct 8. PMID: 29119110
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Diosmin
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Problem Substances : Dexamethasone
[+]

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Pubmed Data : Drug Alcohol Depend. 2015 Feb 1 ;147:144-50. Epub 2014 Dec 10. PMID: 25533893
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Substances : Cannabis
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

Chronic pain treatment with cannabidiol in kidney transplant patients in Uruguay.Feb 28, 2018

Pubmed Data : Transplant Proc. 2018 Mar ;50(2):461-464. PMID: 29579828
Article Published Date : Feb 28, 2018
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Chronic Pain, Organ Transplantation: Kidney
Pharmacological Actions : Analgesics
[+]

Clinical Pilates exercise is an efficient technique for patients experiencing shoulder pain, as it helps reduce pain and disability among them.Sep 30, 2017

Pubmed Data : J Bodyw Mov Ther. 2017 Oct ;21(4):847-851. Epub 2017 Mar 4. PMID: 29037638
Article Published Date : Sep 30, 2017
Study Type : Human Study
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Pilates
Additional Keywords : Chronic Pain, Pilates
[+]

Flotation therapy helped relieve participants stress, anxiety, depression and relief from long lasting pain, while increasing sleep quality and optimism levels. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14:417. Epub 2014 Oct 25. PMID: 25344737
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Chronic Pain, Depression, Depressive Disorder, Sleep Disorders, Stress
Therapeutic Actions : Floatation Tank Immersion, Relaxation Therapy
Additional Keywords : Altered States Of Consciousness, Significant Treatment Outcome
[+]

Forest therapy can help to improve psychological and physiological symptoms of chronic widespread pain.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2016 ;13(3). Epub 2016 Feb 24. PMID: 26927141
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Depression, Quality of Life: Poor
Therapeutic Actions : Shinrin-yoku (taking in the atmosphere of the forest)
Additional Keywords : Significant Treatment Outcome
[+]

Low vitamin D might have an influence on new occurrence of chronic widespread pain. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Musculoskelet Disord. 2016 ;17(1):32. Epub 2016 Jan 16. PMID: 26774507
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Chronic Pain, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

M technique hand massage with or without aromatherapy significantly decreased chronic pain.Nov 30, 2014

Pubmed Data : J Holist Nurs. 2014 Dec ;32(4):304-13; quiz 314-5. Epub 2014 Apr 14. PMID: 24733781
Article Published Date : Nov 30, 2014
Study Type : Human Study
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Aromatherapy Massage, Massage/Therapeutic Touch
[+]

Massage with topical sesame oil was associated with significant reduction in pain severity of patients with limbs trauma.May 31, 2017

Pubmed Data : Complement Ther Med. 2017 Jun ;32:41-48. Epub 2017 Mar 16. PMID: 28619303
Article Published Date : May 31, 2017
Study Type : Human Study
Additional Links
Substances : Sesame Seed Oil
Diseases : Chronic Pain
Therapeutic Actions : Massage/Therapeutic Touch
Pharmacological Actions : Analgesics
[+]

Meditation-CBT intervention reduced pain severity and sensitivity to experimental thermal pain stimuli in patients with opioid-treated CLBP.Mar 09, 2016

Pubmed Data : Pain Med. 2016 Mar 10. Epub 2016 Mar 10. PMID: 26968850
Article Published Date : Mar 09, 2016
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Low Back Pain
Therapeutic Actions : Cognitive Behavioural Approaches, Meditation
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

Mindfulness meditation has prominent effects on psychological aspects on living with chronic pain, improving depression and quality of life.Sep 27, 2017

Pubmed Data : Curr Opin Obstet Gynecol. 2017 Sep 28. Epub 2017 Sep 28. PMID: 28961631
Article Published Date : Sep 27, 2017
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Quality of Life: Poor
Therapeutic Actions : Meditation
Pharmacological Actions : Analgesics
[+]

Night-time sleep disturbance is common in individuals suffering from chronic pain and may be further exacerbated by opioid treatment.Aug 21, 2016

Pubmed Data : Anaesthesia. 2016 Aug 22. Epub 2016 Aug 22. PMID: 27545291
Article Published Date : Aug 21, 2016
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Sleep Disorders
Problem Substances : Morphine
[+]

Reiki may be beneficial to support traditional methods to manage pain and anxiety in children receiving palliative care.Feb 06, 2016

Pubmed Data : Am J Hosp Palliat Care. 2016 Feb 7. Epub 2016 Feb 7. PMID: 26858170
Article Published Date : Feb 06, 2016
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Cancer: Pain , Chronic Pain
Therapeutic Actions : Reiki Therapy
[+]

Some surgical anesthetic compounds might be reduced on days associated with increased geomagnetic activity. Jun 16, 2019

Pubmed Data : Int J Biometeorol. 2019 Jun 17. Epub 2019 Jun 17. PMID: 31209598
Article Published Date : Jun 16, 2019
Study Type : Animal Study, Human Study
Additional Links
Diseases : Chronic Pain
Additional Keywords : Geomagnetic Activity
[+]

Sulfur bath and mud packs lead to significant decrease in lipid peroxidation in plasma and pain intensity in patients with osteoarthritis, while increasing hemoglobin.Jul 01, 2010

Pubmed Data : Vojnosanit Pregl. 2010 Jul;67(7):573-8. PMID: 20707053
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Hemoglobin: Low, Osteoarthritis, Oxidative Stress, Pain
Therapeutic Actions : Bath: Sulfur, Mud therapy
[+]

Supplementation of vitamin C in patients undergoing surgery for foot and ankle trauma helps to reduce analgesic requirements.May 23, 2018

Pubmed Data : Foot Ankle Surg. 2018 May 24. Epub 2018 May 24. PMID: 30321947
Article Published Date : May 23, 2018
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Chronic Pain
Additional Keywords : Medication Reduction
[+]

The inflammation and associated pain involved in dressing changes of burn patients were relieved by puerarin treatment.May 31, 2013

Pubmed Data : Burns. 2013 Jun ;39(4):610-8. Epub 2012 Oct 6. PMID: 23044342
Article Published Date : May 31, 2013
Study Type : Human Study
Additional Links
Substances : Puerarin
Diseases : Burns, Chronic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

The present study suggests that THC does not selectively affect limbic regions, but rather interferes with sensory processing.Oct 29, 2015

Pubmed Data : Neuropsychopharmacology. 2015 Oct 30. Epub 2015 Oct 30. PMID: 26514581
Article Published Date : Oct 29, 2015
Study Type : Human Study
Additional Links
Substances : Delta-tetrahydrocannabinol (THC)
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

The results suggest that Tai Chi may reduce levels of β-endorphin in older adults with chronic pain.Aug 19, 2019

Pubmed Data : Aging Clin Exp Res. 2019 Aug 20. Epub 2019 Aug 20. PMID: 31432432
Article Published Date : Aug 19, 2019
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Inflammation
Therapeutic Actions : Tai Chi
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Theta binaural beats was effective in reducing perceived pain severity for participants.Dec 31, 2015

Pubmed Data : Altern Ther Health Med. 2016 Jan ;22(1):32-8. PMID: 26773319
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Music
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

This presents the first analysis of Italian clinical practice of the use of cannabinoids for a large variety of chronic pain syndromes.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pain Res. 2017 ;10:1217-1224. Epub 2017 May 22. PMID: 28579820
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Ultra-micronized palmitoylethanolamide effects on sleep-wake rhythm and neuropathic pain phenotypes in patients with carpal tunnel syndrome.Dec 31, 2017

Pubmed Data : CNS Neurol Disord Drug Targets. 2018 ;17(4):291-298. PMID: 29676237
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Carpal Tunnel Syndrome, Chronic Pain, Neuropathic Pain, Sleep Disorders
[+]

Vitamin D decreased pain and increased quality of life without significantly affecting nerve conduction in patients with chronic widespread pain.Feb 28, 2017

Pubmed Data : Int J Rehabil Res. 2017 Mar ;40(1):76-83. PMID: 28030514
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Chronic Pain, Vitamin D Deficiency
Pharmacological Actions : Antinoceceptive
[+]

WHEE appears a promising method for pain, anxiety, and depression in patients with chronic pain, compared to standard medical care alone.Jul 17, 2016

Pubmed Data : J Evid Based Complementary Altern Med. 2016 Jul 18. Epub 2016 Jul 18. PMID: 27432773
Article Published Date : Jul 17, 2016
Study Type : Human Study
Additional Links
Diseases : Anxiety, Chronic Pain, Depression
Therapeutic Actions : Emotional Freedom Technique, Integrative Medicine
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Yoga improves occupational performance, depression, and daily activities for people with chronic pain.Dec 31, 2018

Pubmed Data : Work. 2019 ;63(2):181-189. PMID: 31156199
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Depression
Therapeutic Actions : Yoga
Pharmacological Actions : Antidepressive Agents
[+]

Yoga improves quality of life and fall risk-factors in a sample of people with chronic pain and type 2 diabetes.Feb 14, 2018

Pubmed Data : Complement Ther Clin Pract. 2018 Feb 15. Epub 2018 Feb 15. PMID: 29526474
Article Published Date : Feb 14, 2018
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Diabetes Mellitus: Type 2
Therapeutic Actions : Yoga
[+]

A 69-year-old woman had been receiving acupuncture found relief from lower back pain.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Acupunct Meridian Stud. 2015 Oct ;8(5):255-8. Epub 2015 Sep 2. PMID: 26433803
Article Published Date : Sep 30, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Chronic Pain, Pain: Lower Back
Therapeutic Actions : Acupuncture
[+]

The subject in this study is nearly one year using only natural product cannabis plus supplements for his severe pain. May 17, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cases J. 2009 May 18 ;2:7487. Epub 2009 May 18. PMID: 19829975
Article Published Date : May 17, 2009
Study Type : Human: Case Report
Additional Links
Substances : Cannabis
Diseases : Arthritis, Chronic Pain, Fibromyalgia, HIV Infections
Pharmacological Actions : Analgesics
[+]

3,3'-Diindolylmethane nanoencapsulation improves its antinociceptive action.Aug 31, 2019

Pubmed Data : Colloids Surf B Biointerfaces. 2019 Sep 1 ;181:295-304. Epub 2019 May 25. PMID: 31154140
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Antinoceceptive
[+]

A liposomal preparation of black seed oil demonstrated significant analgesic activity in mice.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2017 Mar ;25(3):404-412. Epub 2016 Oct 1. PMID: 28344496
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Liposomal
[+]

Acupuncture is an effective treatment for chronic overlapping pain conditions and provide insight into treatment response variability.Jul 03, 2018

Pubmed Data : J Pain. 2018 Jul 4. Epub 2018 Jul 4. PMID: 29981376
Article Published Date : Jul 03, 2018
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , Chronic Pain
Therapeutic Actions : Acupuncture
Pharmacological Actions : Analgesics
[+]

An extract of Dill had significant antidepressant and analgesic effects compared with the drug references without any adverse effects.Feb 10, 2016

Pubmed Data : Am J Ther. 2016 Feb 11. Epub 2016 Feb 11. PMID: 26872137
Article Published Date : Feb 10, 2016
Study Type : Animal Study
Additional Links
Substances : Dill
Diseases : Chronic Pain, Depression
Pharmacological Actions : Analgesics, Antidepressive Agents
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs, Tramadol
Problem Substances : Sertraline
[+]

Analgesic activity of the aqueous fraction from the ethanolic extract of Chrysanthemum indicumJun 30, 2011

Pubmed Data : Pharmazie. 2011 Jul ;66(7):538-42. PMID: 21812331
Article Published Date : Jun 30, 2011
Study Type : Animal Study
Additional Links
Substances : Chrysanthemum Indicum
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Plant Extracts
[+]

Analgesic effect and related amino acids regulation of ginsenoside Rg3 in mouse pain models.Dec 14, 2019

Pubmed Data : Life Sci. 2019 Dec 15 ;239:117083. Epub 2019 Nov 20. PMID: 31759043
Article Published Date : Dec 14, 2019
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

Anti-allodynic effect of mangiferin in rats with chronic post-ischemia pain.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1119. Epub 2018 Oct 2. PMID: 30333751
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Chronic Pain, Ischemia
Pharmacological Actions : Antinoceceptive
[+]

Antinociceptive effect of methanol extract of Celosia cristata in mice.Oct 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Oct 22 ;16(1):400. Epub 2016 Oct 22. PMID: 27770773
Article Published Date : Oct 21, 2016
Study Type : Animal Study
Additional Links
Substances : Celosia cristata (cockscomb)
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
Additional Keywords : Plant Extracts
[+]

Antinociceptive effect of the essential oil of tarragon.Jan 31, 2014

Pubmed Data : Pharm Biol. 2014 Feb ;52(2):208-12. Epub 2013 Sep 30. PMID: 24074293
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Tarragon
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
Additional Keywords : Essential Oils
[+]

Antinociceptive effects of Salvia divinorum and bioactive salvinorins in experimental pain models.Oct 04, 2019

Pubmed Data : J Ethnopharmacol. 2019 Oct 5:112276. Epub 2019 Oct 5. PMID: 31593812
Article Published Date : Oct 04, 2019
Study Type : Animal Study
Additional Links
Substances : Salvia divinorum
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

Bacopa monnieri extracts have significant anti-hyperglycemic and anti-nociceptive potential.Oct 31, 2015

Pubmed Data : Pak J Pharm Sci. 2015 Nov ;28(6):2135-9. PMID: 26639482
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Chronic Pain, Hyperglycemia
Pharmacological Actions : Antinoceceptive , Hypoglycemic Agents
Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs
[+]

Bioactive chromone constituents from Vitex negundo alleviate pain and inflammation.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pain Res. 2018 ;11:95-102. Epub 2017 Dec 28. PMID: 29343985
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitex negundo
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

Calea zacatechichi extract exhibited antinociceptive effects in a mouse model of abdominal pain.Jan 27, 2016

Pubmed Data : Metab Brain Dis. 2016 Jan 28. Epub 2016 Jan 28. PMID: 26821073
Article Published Date : Jan 27, 2016
Study Type : Animal Study
Additional Links
Substances : Psychedelics:All
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

Central and peripheral antinociceptive effects of ellagic acid in different animal models of pain.May 04, 2013

Pubmed Data : Eur J Pharmacol. 2013 May 5 ;707(1-3):46-53. Epub 2013 Mar 23. PMID: 23528359
Article Published Date : May 04, 2013
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

Chronic intermittent exposure to AM radiofrequency fields alters pain sensation in growing rats.Feb 01, 2006

Pubmed Data : Bioelectromagnetics. 2006 Feb ;27(2):105-11. PMID: 16283665
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain
Anti Therapeutic Actions : Electromagnetic Fields, Electromagnetic Radiation
[+]

Electroacupuncture potentiates peripheral CB2 receptor-inhibited chronic pain in a mouse model of knee osteoarthritis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pain Res. 2018 ;11:2797-2808. Epub 2018 Nov 8. PMID: 30510442
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Osteoarthritis: Knee
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Electroacupuncture treatment exhibited significant antinociceptive effects.Sep 12, 2016

Pubmed Data : Anesth Analg. 2016 Sep 13. Epub 2016 Sep 13. PMID: 27632349
Article Published Date : Sep 12, 2016
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antinoceceptive
[+]

Ethanolic extract of Nigella sativa possessed significant analgesic effect in mice.Jun 30, 2010

Pubmed Data : J Coll Physicians Surg Pak. 2010 Jul ;20(7):464-7. PMID: 20642947
Article Published Date : Jun 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Feverfew flower extract behaves as a potent pain reliever in acute, inflammatory, articular and neuropathic pain.Jul 14, 2015

Pubmed Data : Phytomedicine. 2015 Jul 15 ;22(7-8):752-8. Epub 2015 May 27. PMID: 26141762
Article Published Date : Jul 14, 2015
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Chronic Pain, Neuropathic Pain, Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Geraniol has antinociceptive activity especially in pain related to inflammation.Dec 31, 2016

Pubmed Data : Basic Clin Pharmacol Toxicol. 2017 Jan ;120(1):22-29. Epub 2016 Jul 21. PMID: 27277137
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Antinoceceptive
[+]

Hyperbaric oxygen therapy attenuated chronic constriction injury induced rat neuropathic pain and inflammatory responses.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Headache Pain. 2017 Dec ;18(1):1. Epub 2017 Jan 5. PMID: 28058534
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Inflammation, Neuropathic Pain
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Insufficient or poor-quality sleep may worsen pain and this enhanced pain may not be reduced by analgesics in mice.May 07, 2017

Pubmed Data : Nat Med. 2017 May 8. Epub 2017 May 8. PMID: 28481358
Article Published Date : May 07, 2017
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Insomnia, Sleep Disorders
Additional Keywords : Increased Risk
[+]

Investigation of anti-inflammatory and analgesic activities of camel milk in animal models.Jun 30, 2019

Pubmed Data : Pak J Pharm Sci. 2019 Jul ;32(4(Supplementary)):1879-1883. PMID: 31680087
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Camel Milk
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

Isoliquiritigenin has analgesic and uterine relaxant effects.Aug 31, 2012

Pubmed Data : Phytother Res. 2012 Sep ;26(9):1410-7. Epub 2012 Mar 3. PMID: 22389128
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Kratom analogs might represent a promising new generation of novel pain relievers.Aug 23, 2016

Pubmed Data : J Med Chem. 2016 Aug 24. Epub 2016 Aug 24. PMID: 27556704
Article Published Date : Aug 23, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Kratom
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Luteolin possess potent anti-nociceptive and anti-inflammatory properties and can thus be used in pain management.Dec 31, 2017

Pubmed Data : J Environ Pathol Toxicol Oncol. 2018 ;37(4):351-364. PMID: 30806241
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Antioxidants
[+]

Nettle could be another therapeutic alternative for relieving pain and for minimising the use of drugs that have long-term secondary effects.Nov 19, 2017

Pubmed Data : Arch Physiol Biochem. 2017 Nov 20:1-9. Epub 2017 Nov 20. PMID: 29157001
Article Published Date : Nov 19, 2017
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Allodynia, Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

Obesity may increase susceptibility to chronic pain often due to poor diet.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID: 29436058
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Ginseng, Resveratrol, Sulforaphane
Diseases : Chronic Pain, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Inflammatory Diet, Risk Factors
[+]

Photobiomodulation therapy may be a useful adjunct treatment for chronic pain.Nov 28, 2019

Pubmed Data : Pain Pract. 2019 Nov 29. Epub 2019 Nov 29. PMID: 31782603
Article Published Date : Nov 28, 2019
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Ischemia
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Analgesics
[+]

Photobiomodulation therapy reduces acute pain and inflammation in mice.May 20, 2019

Pubmed Data : J Photochem Photobiol B. 2019 May 21 ;196:111513. Epub 2019 May 21. PMID: 31136885
Article Published Date : May 20, 2019
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Inflammation
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2016 Oct ;6(4):413-423. Epub 2015 Dec 11. PMID: 27774429
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Piperlongumine
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Resveratrol produces analgesia in an animal model of chronic pain. Dec 01, 2010

Pubmed Data : Arch Ital Biol. 2010 Dec;148(4):389-96. PMID: 21308652
Article Published Date : Dec 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Chronic Pain, Pain
Pharmacological Actions : Analgesics
[+]

Simultaneous use of valerian root and turnip extracts is recommended for analgesic effects in both acute and chronic phases of the pain.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Plast Surg. 2018 Sep ;7(3):345-350. PMID: 30560075
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Mustard: Field/Turnip, Valerian
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Plant Extracts
[+]

The alkaloid extract of Peganum harmala seems to have both central and peripheral antinociceptive activities.Feb 11, 2008

Pubmed Data : J Ethnopharmacol. 2008 Feb 12 ;115(3):449-54. Epub 2007 Oct 22. PMID: 18054186
Article Published Date : Feb 11, 2008
Study Type : Animal Study
Additional Links
Substances : Syrian rue
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
Additional Keywords : Plant Extracts
[+]

The dry ripe fruit of A. marmelos possesses significant dual analgesic activities.Feb 28, 2015

Pubmed Data : Pak J Pharm Sci. 2015 Mar ;28(2):515-9. PMID: 25730807
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Bael
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

The natural flavonoid Naringenin elicits analgesia through inhibition of NaV1.8 voltage-gated sodium channels.Nov 06, 2019

Pubmed Data : ACS Chem Neurosci. 2019 Nov 7. Epub 2019 Nov 7. PMID: 31697467
Article Published Date : Nov 06, 2019
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Allodynia, Chronic Pain
Pharmacological Actions : Analgesics
[+]

These data suggest that the Achillea millefolium and Origanum vulgare L. extract encapsulated in liposome gave a synergistic effect.Jul 17, 2017

Pubmed Data : Artif Cells Nanomed Biotechnol. 2017 Jul 18:1-7. Epub 2017 Jul 18. PMID: 28720004
Article Published Date : Jul 17, 2017
Study Type : Animal Study
Additional Links
Substances : Marjoram
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
Additional Keywords : Natural Substance Synergy
[+]

These results support the potential anti-nociceptive effect of stigmasterol in different models of pain.Oct 31, 2017

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2017 Nov ;390(11):1163-1172. Epub 2017 Aug 18. PMID: 28821921
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Chronic Pain
Pharmacological Actions : Analgesics, Antinoceceptive
[+]

These studies indicate the morphine can have a deleterious effect on postoperative pain.Mar 26, 2018

Pubmed Data : Anesth Analg. 2018 Mar 27. Epub 2018 Mar 27. PMID: 29596097
Article Published Date : Mar 26, 2018
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Postoperative Recovery
Problem Substances : Morphine
[+]

This study demonstrates novel characteristics of H. erinaceus in reducing nociceptive behaviour.Dec 31, 2016

Pubmed Data : Int J Med Mushrooms. 2017 ;19(6):499-507. PMID: 29199560
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

TRPA1 mediates the antinociceptive properties of safranal.Jan 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Jan 12. Epub 2019 Jan 12. PMID: 30636360
Article Published Date : Jan 11, 2019
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

A review of guided imagery for pain management in postoperative orthopedic patients.Nov 30, 2017

Pubmed Data : J Holist Nurs. 2017 Dec ;35(4):342-351. Epub 2016 Oct 23. PMID: 30208778
Article Published Date : Nov 30, 2017
Study Type : Review
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Guided Imagery
Pharmacological Actions : Analgesics
[+]

A review of the use and side effects of Kratom. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:968786. Epub 2015 Nov 10. PMID: 26640804
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Kratom
Diseases : Anxiety, Chronic Pain, Depression, Fatigue
Pharmacological Actions : Analgesics, Anti-Anxiety Agents, Antidepressive Agents
[+]

A review on the antinociceptive effects of kratom and its derivatives in animal model.Sep 24, 2017

Pubmed Data : Curr Drug Targets. 2017 Sep 25. Epub 2017 Sep 25. PMID: 28950813
Article Published Date : Sep 24, 2017
Study Type : Review
Additional Links
Substances : Kratom
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

An insight and update on the analgesic properties of vitamin C.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Bioallied Sci. 2018 Jul-Sep;10(3):119-125. PMID: 30237682
Article Published Date : Jun 30, 2018
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Battlefield acupuncture: Opening the door for acupuncture in Department of Defense/Veteran's Administration health care.Aug 31, 2016

Pubmed Data : Nurs Outlook. 2016 Sep-Oct;64(5):491-8. Epub 2016 Jul 20. PMID: 27601311
Article Published Date : Aug 31, 2016
Study Type : Review
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Acupuncture
Pharmacological Actions : Analgesics
[+]

Beta-caryophyllene has anticancer and analgesic properties.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Med. 2016 Oct ;5(10):3007-3017. Epub 2016 Sep 30. PMID: 27696789
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : Beta-Caryophyllene
Diseases : Cancer: Pain , Cancers: All, Chronic Pain
Pharmacological Actions : Analgesics, Antineoplastic Agents
[+]

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history.Dec 04, 2018

Pubmed Data : J Ethnopharmacol. 2018 Dec 5 ;227:300-315. Epub 2018 Sep 8. PMID: 30205181
Article Published Date : Dec 04, 2018
Study Type : Review
Additional Links
Substances : Cannabis
Diseases : Chronic Pain, Colitis, Inflammation, Psychiatric Disorders, Sleep Disorders
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.Nov 14, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2018 Nov 15 ;50:285-299. Epub 2018 Sep 20. PMID: 30466988
Article Published Date : Nov 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Frankincense
Diseases : Chronic Pain, Osteoarthritis: Knee
Pharmacological Actions : Analgesics, Antinoceceptive
Additional Keywords : Natural Substance Synergy, Plant Extracts
[+]

Evidence of the efficacy and safety of cannabis medicines for chronic pain management.Jun 30, 2019

Pubmed Data : Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Jul ;62(7):836-844. PMID: 31139839
Article Published Date : Jun 30, 2019
Study Type : Review
Additional Links
Substances : Cannabis
Diseases : Chronic Pain, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Exogenous melatonin may offer an effective and safe analgesic drug. Sep 30, 2016

Pubmed Data : Dan Med J. 2016 Oct ;63(10). PMID: 27697139
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Hyperbaric oxygen therapy has been shown to reduce pain using animal models.Dec 31, 2015

Pubmed Data : Pain Pract. 2016 06 ;16(5):620-8. Epub 2015 May 19. PMID: 25988526
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Chronic Pain, Fibromyalgia, Headache, Neuralgia
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Analgesics
[+]

In this review cannabis is consistently effective in reducing chronic non-cancer pain.Oct 04, 2017

Pubmed Data : Curr Rheumatol Rep. 2017 Oct 5 ;19(11):67. Epub 2017 Oct 5. PMID: 28983880
Article Published Date : Oct 04, 2017
Study Type : Review
Additional Links
Substances : Cannabis
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Low level laser therapy may be an appropriate modality for reducing pain after surgery.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Lasers Med Sci. 2019 ;10(2):79-85. Epub 2019 Feb 25. PMID: 31360374
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Diseases : Chronic Pain, Postoperative Recovery
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Analgesics
[+]

Melatonin was found to be effective in many of these cases as an anxiolytic and analgesic agent, indicating its clinical application.Sep 30, 2016

Pubmed Data : Exp Ther Med. 2016 Oct ;12(4):1963-1968. Epub 2016 Aug 3. PMID: 27698681
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Anxiety, Chronic Pain
Pharmacological Actions : Analgesics, Anti-Anxiety Agents
[+]

More than 60 research articles in peer-reviewed journals report a staggering 98% efficacy rate with the use of this procedure.May 10, 2016

Pubmed Data : J Holist Nurs. 2016 May 11. Epub 2016 May 11. PMID: 27170647
Article Published Date : May 10, 2016
Study Type : Review
Additional Links
Diseases : Anxiety, Asthma, Chronic Pain, Depression, Fibromyalgia, Phobias, Post-Traumatic Stress Disorders (PTSD), Psychological Distress, Seizures
Therapeutic Actions : Emotional Freedom Technique
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Music as an adjunct to opioid-based analgesia.Jun 22, 2017

Pubmed Data : J Med Toxicol. 2017 Jun 23. Epub 2017 Jun 23. PMID: 28646359
Article Published Date : Jun 22, 2017
Study Type : Review
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Integrative Medicine, Music
[+]

Preclinical studies indicate a potential use of St. John's wort in medical pain management.Feb 11, 2017

Pubmed Data : J Ethnopharmacol. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28216196
Article Published Date : Feb 11, 2017
Study Type : Review
Additional Links
Substances : St. Johns Wort
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

Sauna, mud bath, and thermal water increase betaE levels through conveying heat to the tissues, which results in increased beta-endorphin levels.Jul 01, 2007

Pubmed Data : Eur J Appl Physiol. 2007 Jul;100(4):371-82. Epub 2007 May 5. PMID: 17483960
Article Published Date : Jul 01, 2007
Study Type : Review
Additional Links
Diseases : Chronic Pain, Endorphin Levels: Low, Pain
Therapeutic Actions : Hydrotherapy , Mud therapy , Sauna Therapy
[+]

The authors concluded that cannabinoids demonstrate a modest analgesic effect and are safe for the management of chronic pain.Nov 17, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Nov 18. Epub 2015 Nov 18. PMID: 26581068
Article Published Date : Nov 17, 2015
Study Type : Review
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

The available clinical data support the contention that palmitoylethanolamide has analgesic actions.Jan 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Clin Pharmacol. 2016 10 ;82(4):932-42. Epub 2016 Jun 29. PMID: 27220803
Article Published Date : Jan 09, 2016
Study Type : Review
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

The literature suggests that the medicinal use of cannabis may have a therapeutic role for a multitude of diseases.May 31, 2015

Pubmed Data : Headache. 2015 Jun ;55(6):885-916. Epub 2015 May 25. PMID: 26015168
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Chronic Pain, Headache
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

The possible role of cannabimimetic fatty acid derivatives in the pathological consequences of cancer and inflammation are examined.Oct 31, 2000

Pubmed Data : Chem Phys Lipids. 2000 Nov ;108(1-2):191-209. PMID: 11106791
Article Published Date : Oct 31, 2000
Study Type : Review
Additional Links
Substances : Anandamide, Cannabinoids , Endocannabinoids
Diseases : Asthma, Cachexia, Cancers: All, Chronic Pain, Inflammation
[+]

The role of magnesium in neurological disorders.Jun 05, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Jun 6 ;10(6). Epub 2018 Jun 6. PMID: 29882776
Article Published Date : Jun 05, 2018
Study Type : Review
Additional Links
Substances : Magnesium
Diseases : Anxiety, Chronic Pain, Depression, Headache: Migraine, Neurological Conditions
Pharmacological Actions : Analgesics, Anti-Anxiety Agents, Antidepressive Agents, Neuroprotective Agents
[+]

Therapeutic fasting has mood-enhancing and pain-relieving effects in chronic pain syndrome.Apr 01, 2010

Pubmed Data : Curr Pain Headache Rep. 2010 Apr;14(2):80-7. PMID: 20425196
Article Published Date : Apr 01, 2010
Study Type : Review
Additional Links
Diseases : Chronic Pain
Therapeutic Actions : Fasting/Caloric Restriction
[+]

There is a large body of preclinical evidence in support of cannabinoids as potential analgesic agents.Dec 31, 2016

Pubmed Data : Adv Pharmacol. 2017 ;80:437-475. Epub 2017 Jun 20. PMID: 28826543
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Brain Inflammation , Chronic Pain, Neuropathic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

This paper discusses the possible mechanisms of melatonins analgesic properties. Mar 15, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Ther. 2016 Mar 16. Epub 2016 Mar 16. PMID: 26984272
Article Published Date : Mar 15, 2016
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Chronic Pain, Fibromyalgia, Headache, Irritable Bowel Syndrome, Rheumatoid Arthritis
Pharmacological Actions : Analgesics
[+]

This review adds further support that currently available cannabinoids are safe, modestly effective analgesics.May 31, 2015

Pubmed Data : J Neuroimmune Pharmacol. 2015 Jun ;10(2):293-301. Epub 2015 Mar 22. PMID: 25796592
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

This review focuses on pre-clinical and clinical studies in the treatment of pathological pain.Sep 14, 2018

Pubmed Data : Phytomedicine. 2018 Sep 15 ;48:129-140. Epub 2018 Apr 17. PMID: 30195871
Article Published Date : Sep 14, 2018
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

This review suggests that cannabinoids may provide effective analgesia in chronic neuropathic pain conditions that are refractory to other treatments.Dec 31, 2014

Pubmed Data : J Oral Facial Pain Headache. 2015 ;29(1):7-14. PMID: 25635955
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Cannabidiol, Cannabinoids , Cannabis, Delta-tetrahydrocannabinol (THC)
Diseases : Chronic Pain, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Various spa therapies have therapeutic value for chronic low back pain, stabilized rheumatoid arthritis, ankylosing spondylitis and fibromyalgia. Jun 01, 2009

Pubmed Data : Bull Acad Natl Med. 2009 Jun;193(6):1345-56; discussion 1356-8. PMID: 20120164
Article Published Date : Jun 01, 2009
Study Type : Review
Additional Links
Substances : Mineral Water
Diseases : Arthritis: Rheumatoid, Chronic Pain, Fibromyalgia, Low Back Pain, Spondylitis: Ankylosing
Therapeutic Actions : Balneotherapy, Hydrotherapy , Mud therapy , Spa Bathing
[+]

Vitamin C appears to be a safe and effective adjunctive therapy for acute and chronic pain relief in specific patient groups.Apr 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Transl Med. 2017 Apr 14 ;15(1):77. Epub 2017 Apr 14. PMID: 28410599
Article Published Date : Apr 13, 2017
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Chronic Pain, Neuralgia
Pharmacological Actions : Analgesics
[+]

Willow oil, curcuma, and garlic have potent anti-inflammatory and analgesic properties.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2015 May-Jun;5(3):182-202. PMID: 26101752
Article Published Date : Apr 30, 2015
Study Type : Review
Additional Links
Substances : Garlic, Turmeric, Willow Bark
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

Copyright: sabelskaya / 123RF Stock Photo

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