Demyelinating Diseases

Name	AC	CK
Vitamin D	26	158
Cannabis	27	152
Cannabidiol	27	124
Delta-tetrahydrocannabinol (THC)	15	106
Cannabinoids	22	84
Vitamin E	8	54
Coenzyme Q10	6	43
Vitamin B-12	7	37
Curcumin	11	30
Testosterone	5	25
Cannabinoids: Synthetic	5	24
Probiotics	6	24
Omega-3 Fatty Acids	3	21
Vitamin B12: methylcobalamin	3	21
B-complex	1	20
Melatonin	8	20
EGCG (Epigallocatechin gallate)	7	18
Progesterone	6	18
Alpha-Lipoic Acid	5	15
Polyunsaturated Fatty Acids (PUFAs)	3	15
Resveratrol	10	15
Antioxidant formulas	3	13
Estriol	3	12
Estradiol (E(2))	7	11
Folic Acid	2	11
Glutathione	2	11
Vitamin A	2	11
Bifidobacterium Bifidum	1	10
Bifidobacterium Infantis	1	10
Cocoa	1	10
Copper	1	10
Creatine	1	10
Fruit: All	1	10
Lactobacillus Acidophilus	1	10
Lactobacillus casei	1	10
Lactobacillus fermentum	1	10
Marijuana	1	10
Olive	1	10
Olive Oil	1	10
Phosphatidylethanolamine	1	10
Phosphatidylserine	1	10
Selenium	1	10
Superoxide dismutase	1	10
Threonine	1	10
Vegetables: All	1	10
Vitamin K2	1	10
Whey	1	10
Zinc	1	10
Glycoaminoglycans	4	8
Insulin-like Growth Factor (IGF-1)	4	7
Chrysin	2	6
DHA (Docosahexaenoic Acid)	3	6
St. Johns Wort	4	6
Genistein	3	5
Nigella sativa (aka Black Seed)	3	5
Palmitoylethanolamide	2	5
Tripterygium wilfordii	3	5
Berberine	2	4
EPA (Eicosapentaenoic Acid)	2	4
Gamma-Linoleic Acid (GLA)	1	4
Ginkgo biloba	3	4
Tanshinone IIA	2	4
Vitamin C	2	4
Arginine	2	3
Celery seed	2	3
Cinnamon	2	3
Gc protein-derived macrophage activating factor (GcMAF)	1	3
Ginger	2	3
Ginsenosides	2	3
Luteolin	2	3
Magnesium	1	3
Panax Ginseng	2	3
Penaeus Latisculatus (prawn)	2	3
Polyphenols	3	3
Saffron	2	3
Silica	1	3
Stilbenes	2	3
18β-Glycyrrhetinic Acid	1	2
5-HTP (5-Hydroxytryptophan)	1	2
6-Shogaol	1	2
Acetyl-l-carnitine	1	2
Aloe Vera	1	2
Amino Acids: Branched Chain	1	2
Arctigenin	1	2
Astaxanthin	1	2
Bee Venom	1	2
Beta-Caryophyllene	1	2
Beta-Elemene	1	2
Blueberry	1	2
Burdock	1	2
Caprylic Acid	1	2
Chinese Herbal Formula: Qichu Fujin Recipe	1	2
Chinese Skullcap	1	2
Coconut Oil	1	2
EDTA (synthetic amino acid compound)	1	2
Fiber	1	2
Fisetin	1	2
Fucoidan	1	2
Galactooligosaccharides	1	2
Ginseng (Korean)	1	2
Glucosamine	1	2
Glycyrrhizin	1	2
Goldenthread	1	2
Hesperidin	1	2
Huperzine	1	2
Hydrogen Water	1	2
Isoliquiritigenin	1	2
Licorice	1	2
Ligustrazine	1	2
Mangosteen	1	2
Moringa oleifera	1	2
Myricetin	1	2
Naringenin	1	2
Nerve growth factor	1	2
Oleanolic acid	1	2
Paeoniflorin	1	2
Parthenolide	1	2
Peony	1	2
Phytosterols	1	2
Piperlongumine	1	2
Placenta Extract (or Stem Cells)	1	2
Prebiotics	1	2
Pyruvate	1	2
Red Wine Extract	2	2
Riboflavin (Vitamin B-2)	2	2
Rosemaric Acid	1	2
Rosemary	1	2
S-Adenosylmethionine (SAMe)	1	2
SAMe (S-adenosylmethionine)	2	2
Scolopendra subspinipes mutilans	1	2
Sesame Seed Oil	1	2
Thyme	1	2
Thymus Extract	1	2
Triptolide	1	2
Vitamin E: alpha tocopherol	1	2
Wen Pi Tang	1	2
phytoestrogens	1	2
Andrographis	1	1
Astragaloside	1	1
Beta Sitosterol	1	1
Broccoli	1	1
Cannabichromene	1	1
Cannabigerol	1	1
Carnitine	1	1
Cranberry	1	1
Diosgenin	1	1
Endocannabinoids	1	1
Fish Oil	1	1
Flavonoids	1	1
Frankincense	1	1
Ginseng	1	1
Grape	1	1
Haritaki (Terminalia chebula)	1	1
Herbal Therapies (Unspecified in Abstracts)	1	1
Hydroxytyrosol	1	1
Kava Kava	1	1
Lactobacillus probiotics	1	1
Lion's Mane (Hericium Erinaceus)	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Safranal	1	1
Sodium benzoate (cinnamon metabolite)	1	1
Sulforaphane	1	1
Tauroursodeoxycholic acid	1	1
Thyroid hormones	1	1
Tibetan Herbal Formula: Padma 28	1	1
Turmeric	1	1
Tyrosol	1	1
Valerian	1	1
Vitamin B-3 (Niacin)	1	1
Vitamin B-5 (Pantothenic Acid)	1	1
Vitamin B-6	1	1
Wine	1	1

Name	AC	CK
Pesticides	5	41
Gliadin	4	40
Lead	6	33
Statin Drugs	7	32
Fingolimod	4	31
Mercury	4	27
Gluten	5	23
Cow Milk	2	20
Dental Amalgams	1	20
Tobacco	2	20
Lyme's Disease (Borrelia burgdorferi)	5	15
Agricultural Chemicals	1	10
Butyrophilin	1	10
Candida species	1	10
Casein	1	10
Chlorpyrifos	1	10
L-glutamic Acid	1	10
Monosodium Glutamate (MSG)	1	10
Nicotine	1	10
Persistent organic pollutants (POPs)	1	10
Infliximab	2	9
Aluminum	3	8
Simvastatin	4	7
Cadmium	2	6
Etanercept	1	6
Tumor Necrosis Factor (TNF) Inhibitor Drugs	1	6
Antibiotics	1	3
Bisphenol A	2	3
Fusidic acid	1	3
Industrial Copper (inorganic)	1	3
interferon beta-1b	1	3
Acetyl ethyl tetramethyl tetralin (AETT)	1	2
Carbonyl Iron	1	2
Concanavalin A	1	2
Freund adjuvant	1	2
Lectins	1	2
Lovastatin	2	2
Perfume: Synthetic	1	2
Thimerosal	1	2
Wheat Germ Agglutinin (WGA)	1	2
Barium	1	1
Bisphenol S	1	1
Epstein-Barr Virus	1	1
Excitotoxins	1	1
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	1
Sodium Selenite	1	1
Staphylococcus aureus: Enterotoxin A	1	1

Name	AC	CK
Sunlight exposure	6	71
Pilates	3	40
Exercise	8	39
Ai-Chi Aquatic Exercise	2	20
Yoga	2	20
Stem Cell Related Therapy	4	15
Dietary Modification: Low Carbohydrate/Ketogenic	2	11
Acupuncture	1	10
Biofeedback	1	10
Craniosacral Therapy	1	10
Cryotherapy	1	10
Deep Breathing	1	10
Dietary Modification: Mediterranean Diet	1	10
Loving	1	10
Massage/Therapeutic Touch	1	10
Meditation	1	10
Ozone Therapy	1	10
Reflexology	1	10
Relaxation Therapy	1	10
Spiritual/Religious Practice	1	10
Tai Chi	1	10
Therapeutic Breathing	1	10
Ultrasound therapy	1	10
Whole-Body Vibration	1	10
Electroacupuncture	2	4
Fasting/Caloric Restriction	2	4
Laser Treatment: Low-Level	2	3
Hyperbaric Treatment	1	2
Intermittent Hypoxia (low oxygen)	1	2
Placentophagy	1	2
Aquatic therapy	1	1
Dietary Modification: High-Fat/Low-Carbohydrate	1	1
Laser Treatment	1	1

Name	AC	CK
Vaccination: All	25	185
Vaccination: Hepatitis B	11	80
Vaccination: Influenza	7	46
Vaccination: HPV (Gardasil)	4	32
Electromagnetic Fields	1	20
Vaccination: Mumps-Measles-Rubella (MMR)	5	20
Cesarean Delivery	1	10
Vaccination: Yellow Fever	1	10
Vaccination: Rabies	2	5
Vaccination: Diphtheria-Pertussis-Tetanus	2	3
Vaccination: Tetanus	2	3
Vaccination: Varicella (Chicken pox)	2	3
Vaccination: Haemophilus Influenzae	1	2
Vaccination: Lyme disease	1	2
Vaccination: Rotavirus	1	2
Nocebo Effect	1	1

[+]

Cannabinoids may have possible therapeutic properties for the management of the multiple sclerosis.Nov 19, 2010

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2010 Nov 19. Epub 2010 Nov 19. PMID: 21094240

Article Published Date : Nov 19, 2010

Study Type : Meta Analysis

Additional Links

Substances : Cannabinoids

Diseases : Multiple Sclerosis

[+]

Dental amalgams (mercury exposure) increase the risk of multiple sclerosis. Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : J Public Health Dent. 2007;67(1):64-6. PMID: 17436982

Article Published Date : Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : Mult Scler Relat Disord. 2019 Feb ;28:199-212. Epub 2019 Jan 3. PMID: 30623859

Pubmed Data : Eur J Clin Microbiol Infect Dis. 2010 Sep;29(9):1139-45. Epub 2010 Jun 17. PMID: 20556470

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Diseases : Multiple Sclerosis

Problem Substances : Candida species

[+]

Cannabis extracts can be a useful and safe option for patients with MS with moderate to severe spasticity resistant to common antispastic drugs.May 08, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Muscle Nerve. 2006 Nov;34(5):586-94. PMID: 16881064

Article Published Date : Nov 01, 2006

Study Type : Human Study

Additional Links

Substances : Creatine

Diseases : Charcot-Marie-Tooth Disease

[+]

Click here to read the entire abstract

Pubmed Data : Amyotroph Lateral Scler. 2011 Mar ;12(2):105-8. Epub 2010 Jul 26. PMID: 20653520

Article Published Date : Feb 28, 2011

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Therapeutic Actions : Spiritual/Religious Practice

[+]

Exposure to pesticides like chlorpyrifos may contribute to the pathogenesis of multiple sclerosis. May 01, 2002

Click here to read the entire abstract

Pubmed Data : Arch Environ Health. 2002 May-Jun;57(3):181-7. PMID: 12507170

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS Med. 2015 Aug ;12(8):e1001866. Epub 2015 Aug 25. PMID: 26305103

Click here to read the entire abstract

Pubmed Data : Ann N Y Acad Sci. 2009 Sep;1173:343-9. PMID: 19758171

Article Published Date : Sep 01, 2009

Hepatitis B vaccine is associated with an increased risk of multiple sclerosis. Sep 14, 2004

Click here to read the entire abstract

Pubmed Data : Neurology. 2004 Sep 14;63(5):838-42. PMID: 15365133

Article Published Date : Sep 14, 2004

Study Type : Human Study

Additional Links

Diseases : Demyelinating Diseases, Hepatitis B , Multiple Sclerosis, Vaccine-induced Toxicity

Additional Keywords : Hepatitis B Vaccine

Anti Therapeutic Actions : Vaccination: All

[+]

High dose vitamin D3 improves the inflammation/immune status in patients with multiple sclerosis. Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : PLoS One. 2010;5(12):e15235. Epub 2010 Dec 13. PMID: 21179201

Click here to read the entire abstract

Pubmed Data : J Neurol Neurosurg Psychiatry. 2019 Feb 13. Epub 2019 Feb 13. PMID: 30760645

Click here to read the entire abstract

Pubmed Data : J Child Neurol. 2010 Mar;25(3):321-7. PMID: 20189933

Article Published Date : Mar 01, 2010

Study Type : Human Study

Additional Links

Diseases : Demyelinating Diseases

Anti Therapeutic Actions : Vaccination: All, Vaccination: HPV (Gardasil)

[+]

Human Papilloma Virus (HPV) vaccine is associated with demyelinating events. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Mult Scler. 2009 Jan;15(1):116-9. Epub 2008 Sep 19. PMID: 18805844

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 1997 Jun 15;145(12):1076-88. PMID: 9199537

Article Published Date : Jun 15, 1997

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Problem Substances : Agricultural Chemicals, Pesticides

Adverse Pharmacological Actions : Neurotoxic

[+]

Omega 3 fatty acids have therapeutic value in the treatment of Mulitple Sclerosis. Feb 01, 2009

Click here to read the entire abstract

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):131-6. Epub 2009 Jan 25. PMID: 19171471

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Multiple Sclerosis

[+]

Selenium, glutathione, copper/zinc and superoxide dismutase may have therapeutic value in ALS. Jan 01, 1995

Click here to read the entire abstract

Pubmed Data : Scand J Rheumatol. 1995;24(2):85-93. PMID: 9726810

Article Published Date : Jan 01, 1995

Study Type : Human Study

Additional Links

Substances : Antioxidant formulas, Copper, Glutathione, Selenium, Superoxide dismutase, Zinc

Diseases : Amyotrophic Lateral Sclerosis

Pharmacological Actions : Calcium Channel Blockers

[+]

Serum homocysteine may play a role in cognitive dysfunction in MS patients.Feb 20, 2018

Click here to read the entire abstract

Pubmed Data : Int J Neurosci. 2018 Feb 21:1-7. Epub 2018 Feb 21. PMID: 29384421

Article Published Date : Feb 20, 2018

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Homocysteine: Elevated, Multiple Sclerosis

Additional Keywords : Cognitive Decline/Dysfunction, Homocysteine: Elevated, Multiple Sclerosis, Risk Factors

[+]

[+]

THC/CBD oromucosal spray has shown to be effective in improving overactive bladder symptoms in multiple sclerosis patients.Oct 18, 2017

Click here to read the entire abstract

Pubmed Data : Neurol Sci. 2017 Oct 19. Epub 2017 Oct 19. PMID: 29052091

Article Published Date : Oct 18, 2017

Study Type : Human Study

Additional Links

Substances : Cannabidiol, Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Multiple Sclerosis, Overactive Bladder

[+]

THC:CBD oromucosal spray provided symptomatic relief of MS spasticity with good tolerability in a relevant number of previously resistant patients.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Eur Neurol. 2015 ;74(3-4):178-85. Epub 2015 Nov 17. PMID: 26571097

Additional Keywords : Molecular Mimicry

Problem Substances : Butyrophilin, Cow Milk

Adverse Pharmacological Actions : Immunoreactive

[+]

There is an association between blood lead and the risk of amyotrophic lateral sclerosis.May 15, 2010

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2010 May 15;171(10):1126-33. Epub 2010 Apr 20. PMID: 20406759

Article Published Date : May 15, 2010

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis, Lead Poisoning

Problem Substances : Lead

[+]

There is increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosisApr 15, 2008

Click here to read the entire abstract

Pubmed Data : J Neurol Sci. 2008 Apr 15;267(1-2):66-9. Epub 2007 Oct 24. PMID: 17961597

Article Published Date : Apr 15, 2008

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Amyotrophic Lateral Sclerosis, Mitochondrial Diseases, Oxidative Stress

Additional Keywords : Diseases that are Linked

[+]

[+]

These results found that preonset sun exposure was protective against subsequent conversion to MS and relapses.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Neurol. 2018 ;9:16. Epub 2018 Feb 1. PMID: 29449827

Click here to read the entire abstract

Pubmed Data : Arch Neurol. 1992 Sep;49(9):923-6. PMID: 1520082

Article Published Date : Sep 01, 1992

Study Type : Human Study

Additional Links

Substances : Threonine

Diseases : Multiple Sclerosis

Pharmacological Actions : Antispasmodic

[+]

Tobacco consumption is associated with increased risk for ALS. Jan 15, 2000

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2000 Jan 15;151(2):156-63. PMID: 10645818

Article Published Date : Jan 15, 2000

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis, Nicotine/Tobacco Toxicity , Smoking

Problem Substances : Nicotine, Tobacco

Adverse Pharmacological Actions : Neurotoxic

[+]

Diseases : Amyotrophic Lateral Sclerosis

[+]

Whole body cryotherapy appears to reduce oxidative stress in multiple sclerosis patients.Sep 01, 2011

Click here to read the entire abstract

Pubmed Data : Pol Merkur Lekarski. 2011 Sep ;31(183):150-3. PMID: 21991843

Article Published Date : Sep 01, 2011

Study Type : Human Study

Additional Links

Diseases : Multiple Sclerosis, Oxidative Stress

Therapeutic Actions : Cryotherapy

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

[+]

Click here to read the entire abstract

Pubmed Data : Eur J Clin Microbiol Infect Dis. 2011 May 1. Epub 2011 May 1. PMID: 21533622

Article Published Date : May 01, 2011

Study Type : Human: Case Report

Additional Links

Diseases : Candidiasis, Fungal Infection, Multiple Sclerosis

Additional Keywords : Diseases that are Linked

[+]

GcMAF shows therapeutic potency in the treatment of Multiple sclerosis.Jun 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anticancer Res. 2016 Jul ;36(7):3771-4. PMID: 27354653

Article Published Date : Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : Curr Aging Sci. 2011 Aug 12. Epub 2011 Aug 12. PMID: 21834785

Article Published Date : Aug 12, 2011

Study Type : Human: Case Report

Additional Links

Diseases : Multiple Sclerosis

Problem Substances : Cadmium, Industrial Copper (inorganic), Lead

[+]

Lead toxicitity may be associated with ALS. May 01, 1998

Click here to read the entire abstract

Pubmed Data : Rev Neurol (Paris). 1998 May;154(4):345-7. PMID: 9773065

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2012 ;7(4):e35758. Epub 2012 Apr 26. PMID: 22563398

Click here to read the entire abstract

Pubmed Data : J Mol Neurosci. 2011 May ;44(1):31-40. Epub 2011 Jan 19. PMID: 21246417

Article Published Date : Apr 30, 2011

Study Type : Animal Study

Additional Links

Substances : Beta-Elemene

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation

[+]

Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosisMay 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : PLoS One. 2010;5(10):e13489. Epub 2010 Oct 19. PMID: 20976070

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Blood-Brain-Barrier Disorders, Brain Inflammation , Multiple Sclerosis

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Berberine promotes neurite extension and axonal regeneration in injured nerves of the peripheral nervous systemApr 01, 2012

Click here to read the entire abstract

Pubmed Data : J Med Food. 2012 Apr ;15(4):413-7. Epub 2012 Feb 8. PMID: 22316297

Article Published Date : Apr 01, 2012

Study Type : Animal Study

Additional Links

Substances : Berberine, Goldenthread

Diseases : Demyelinating Diseases, Peripheral Nerve Diseases, Peripheral Neuropathies

Pharmacological Actions : Neuritogenic

Additional Keywords : Nerve Regeneration, Remyelination, Sciatic Nerve

[+]

Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.Mar 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 Apr 1 ;18(4). Epub 2017 Apr 1. PMID: 28368293

Article Published Date : Mar 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Beta-Caryophyllene

Diseases : Inflammation: Brain, Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

Additional Keywords : Cannabinoid Receptors

[+]

Blueberries have a beneficial effect in an experimental animal model of multiple sclerosis. Feb 10, 2012

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2012 Feb 10. Epub 2012 Feb 10. PMID: 22243431

Article Published Date : Feb 10, 2012

Study Type : Animal Study

Additional Links

Substances : Blueberry

Diseases : Multiple Sclerosis

[+]

Click here to read the entire abstract

Pubmed Data : Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Sep;6(3):182-4. PMID: 16183560

Article Published Date : Sep 01, 2005

Study Type : Animal Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : Amyotrophic Lateral Sclerosis

[+]

Cannabis contains a number of compounds which may have therapeutic value in delaying the progression of ALS. Mar 01, 2004

Click here to read the entire abstract

Pubmed Data : Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):33-9. PMID: 15204022

Article Published Date : Mar 01, 2004

Study Type : Animal Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : Amyotrophic Lateral Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

Cannabis extracts have therapeutic potential to slow multiple sclerosis progression and repair the central nervous system.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : Br J Pharmacol. 2015 Jul ;172(14):3579-95. Epub 2015 May 20. PMID: 25857324

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory

Additional Keywords : Plant Extracts

[+]

[+]

Co-administration of IGF-I and glycosaminoglycans greatly delays motor neuron disease in the mouse model.Apr 01, 2002

Click here to read the entire abstract

Pubmed Data : J Neurochem. 2002 Apr;81(1):194-202. PMID: 12067233

Article Published Date : Apr 01, 2002

Study Type : Animal Study

Additional Links

Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)

Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Daru. 2015 ;23(1):48. Epub 2015 Oct 21. PMID: 26489494

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Multiple Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status.Jul 10, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 2009 Apr;72(4):434-43. Epub 2009 Jan 19. PMID: 14561497

Article Published Date : Apr 01, 2009

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 1999 May 19;258(3):685-8. PMID: 10329446

Article Published Date : May 19, 1999

Study Type : Animal Study

Additional Links

Substances : Genistein, phytoestrogens

Diseases : Amyotrophic Lateral Sclerosis, Stroke, Stroke: Attenuation/Recovery

Pharmacological Actions : Neuroprotective Agents

[+]

ginger extract modulates the expression of the IL-27 and IL-33 in the spinal cord of EAE mice and ameliorates the clinical symptoms of disease.Nov 14, 2014

Click here to read the entire abstract

Pubmed Data : J Neuroimmunol. 2014 Nov 15 ;276(1-2):80-8. Epub 2014 Aug 19. PMID: 25175065

Click here to read the entire abstract

Pubmed Data : Nutr Clin Pract. 2005 Dec;20(6):674-7. PMID: 16301624

Article Published Date : Dec 01, 2005

Study Type : Animal Study

Additional Links

Substances : Glucosamine

Diseases : Encephalomyelitis, Multiple Sclerosis

[+]

Click here to read the entire abstract

Pubmed Data : Brain Behav Immun. 2015 Jun 27. Epub 2015 Jun 27. PMID: 26130320

Article Published Date : Jun 26, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory

[+]

Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke.Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : Pediatr Res. 2011 Jan;69(1):51-5. PMID: 20856166

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Brain Inflammation , Demyelinating Diseases, Neonatal Stroke, Stroke: Attenuation/Recovery

Pharmacological Actions : Neuroprotective Agents, Neurorestorative

Additional Keywords : Remyelination

[+]

[+]

Non-invasive assessment of disease progression and neuroprotective effects of dietary coconut oil supplementation in the Amyotrophic lateral sclerosis.Sep 18, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neuroimage Clin. 2018 Sep 19 ;20:1092-1105. Epub 2018 Sep 19. PMID: 30368196

Article Published Date : Sep 18, 2018

Study Type : Animal Study

Additional Links

Substances : Coconut Oil

Diseases : Amyotrophic Lateral Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

Oleanolic acid reduces the severity and development of autoimmune encephalomyelitis and improves the TH1/TH2 polarization in an experimental model of multiple sclerosis. Jan 01, 2009

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Pubmed Data : Physiol Res. 2009;58(4):511-9. Epub 2008 Jul 25. PMID: 19679109

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Oleanolic acid

Diseases : Immune Dysregulation: TH1/TH2 imbalance, Multiple Sclerosis

[+]

Oral administration of cinnamon powder may be beneficial in MS patients and that no other existing anti-MS therapies could be so economical and trouble free as this approach.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(1):e0116566. Epub 2015 Jan 8. PMID: 25569428

Click here to read the entire abstract

Pubmed Data : Mol Neurobiol. 2017 Aug 18. Epub 2017 Aug 18. PMID: 28822061

Article Published Date : Aug 17, 2017

Study Type : Animal Study

Additional Links

Substances : Luteolin, Palmitoylethanolamide

Diseases : Multiple Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

Parthenolide modulates immune response in cells from C57BL/6 mice induced with experimental autoimmune encephalomyelitis.Apr 30, 2017

Click here to read the entire abstract

Pubmed Data : Planta Med. 2017 May ;83(8):693-700. Epub 2016 Dec 20. PMID: 27997959

Pubmed Data : Iran J Pharm Res. 2016 ;15(4):834-841. PMID: 28243280

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Mercury Poisoning, Multiple Sclerosis

Problem Substances : Mercury

Adverse Pharmacological Actions : Neurotoxic

[+]

Resveratrol ameliorates the clinical severity of MS through maintaining the BBB integrity in EAE mice.Aug 16, 2016

Click here to read the entire abstract

Pubmed Data : J Neurophysiol. 2016 Aug 17:jn.00510.2016. Epub 2016 Aug 17. PMID: 27535376

Article Published Date : Aug 16, 2016

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Blood Brain Barrier

[+]

Resveratrol may improve Multiple Sclerosis by causing apoptosis in activated T cells. Dec 01, 2007

Click here to read the entire abstract

Pubmed Data : Mol Pharmacol.2007 Dec;72(6):1508-21. Epub 2007 Sep 14. PMID: 17872969

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Multiple Sclerosis

Additional Keywords : Autoimmunity

[+]

Resveratrol relieves symptoms in experimental autoimmune encephalomyelitis, an animal model of Multiple Sclerosis, by modulating cytokines and macrophages. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2009 Jan;9(1):134-43. Epub 2008 Nov 18. PMID: 19022403

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Multiple Sclerosis

Pharmacological Actions : Interleukin-6 Downregulation

Additional Keywords : Cytokine Modulation

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View the Evidence: 456 Abstracts with Demyelinating Diseases Research

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Cannabinoids may have possible therapeutic properties for the management of the multiple sclerosis.Nov 19, 2010

Dental amalgams (mercury exposure) increase the risk of multiple sclerosis. Jan 01, 2007

Low maternal exposure to ultraviolet radiation in pregnancy is associated with increased risk of multiple sclerosis in offspring. Jan 01, 2010

Mind-body medicine for multiple sclerosis: a systematic review.Dec 31, 2011

Pilates is a feasible therapy for people with multiple sclerosis that can lead to improvements on their physical function.Jan 31, 2019

There is a relation between Epstein-Barr virus and multiple sclerosis.Jul 01, 2010

There is a strong association between UV radiation (sunlight exposure) and multiple sclerosis.Aug 01, 2009

There is an association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis.Feb 01, 2003

These findings suggest that vitamin D supplementation may have a therapeutic role in the treatment of multiple sclerosis.Oct 02, 2018

Whole plant cannabis provides subjective symptom relief in multiple sclerosis. Jan 01, 2009

"Chart-confirmed guillain-barre syndrome after 2009 H1N1 influenza vaccination among the Medicare population, 2009-2010."Sep 14, 2013

"Risk of Guillain-Barré syndrome after 2010-2011 influenza vaccination."Apr 30, 2013

"Risk of Guillain-Barré syndrome after 2010-2011 influenza vaccination."Apr 30, 2013

"Yellow fever vaccination and increased relapse rate in travelers with multiple sclerosis."Oct 01, 2011

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

A higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS.Dec 19, 2003

A majority of patients with amyotrophic lateral sclerosis had signs of intestinal inflammation.Aug 31, 2017

A Mediterranean diet rich in olive oil may have a protective role in multiple sclerosis. Jun 01, 2009

Ai-Chi aquatic exercise improves the condition of patients with multiple sclerosis. Jan 01, 2012

Ai-Chi may improve balance, functional mobility, upper and lower extremity muscle strength and fatigue in patients with Multiple sclerosis.Dec 31, 2012

Air pollution by particulate matter PM10 may trigger multiple sclerosis relapses.Jun 30, 2017

An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.Mar 31, 2017

Antibodies to gliadin are more common in demyelinating diseases of the nervous sytem. Jan 06, 2013

Antibody titers against EBV in MS patients rise after the onset of the disease and indicate that vitamin D3 supplementation could limit augmentation of these titers in MS patients.Feb 28, 2015

Autologous bone marrow-derived stem cell therapy is safe and feasible in patients of ALS.Aug 31, 2012

Bifidobacterium alleviated Guillain-Barré syndrome by regulating Th cells.Jul 31, 2018

Biofeedback improves bowel symptoms in patients with multiple sclerosis. Sep 01, 2011

Breathing exercises may be beneficial in patients with mild to moderate stages of multiple sclerosis.Oct 31, 2016

Candida infection is more common in multiple sclerosis patients.Sep 01, 2010

Cannabis extracts can be a useful and safe option for patients with MS with moderate to severe spasticity resistant to common antispastic drugs.May 08, 2016

Cannabis-based extracts have therapeutic value for bladder dysfunction in advanced mutiple sclerosis. Aug 01, 2004

Cannabis-based medicine is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain and is mostly well tolerated.Sep 27, 2005

Cannabis-based medicine may represent a useful new agent for treatment of the symptomatic relief of spasticity in MS.Feb 28, 2007

Celiac disease has been associated with recurrent guillain barre syndrome.Sep 07, 2010

Cesarean delivery appears to increase the risk of multiple sclerosis.Oct 07, 2011

Children vaccinated with MMR before age 10 are at significantly higher risk of multiple sclerosis. Jan 01, 2009

Cigarette smoking is associated with increased risk for ALS. Jan 01, 1999

Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. Dec 13, 2005

Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis.Dec 31, 2018

Continuous fingolimod treatment has been linked to nasopharyngitis (34%), headache (30%), fatigue (19%) and influenza (18%). Feb 01, 2010

CoQ10 supplementation at a dosage of 500 mg appears to decrease inflammatory markers in patients with MS.Apr 30, 2015

Craniosacral therapy is effective for treating lower urinary tract symptoms and improving quality of life in multiple sclerosis patients. May 01, 2009

Creatine may have therapeutic activity in patients with Charcot-Marie-Tooth disease.Nov 01, 2006

Delta-tetrahydrocannabinol (THC) and cannabidiol have therapeutic value in the management of spasticity associated wtih multiple sclerosis. Aug 01, 1996

Diaphragm training has value in amyotrophic lateral sclerosis.Nov 30, 2008

Dronabinol is a safe long-term treatment option for neuropathic pain patients.Oct 25, 2017

EGCG given to patients with multiple sclerosis over 12 weeks improved muscle metabolism during moderate exercise to a greater extent in men than in women.Feb 28, 2015

Epstein-Barr virus infection may be associated with increased risk of multiple sclerosisDec 26, 2001

Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis.Mar 31, 2018

Exercise may be an additional modifiable protective factor for multiple sclerosis.Feb 28, 2017

Existential well-being, as well as spirituality issues, perceived by SALS patients seems to be directly related with quality of life, severity of mood disturbance and burden experienced by their caregivers.Feb 28, 2011

Exposure to pesticides like chlorpyrifos may contribute to the pathogenesis of multiple sclerosis. May 01, 2002

Fingolimod has been linked to a wide variety of side effects, including fatal viral infection.Feb 04, 2010

Fingolimod treatment is associated with a number of adverse side effects.Feb 04, 2010

Flavonoid rich dark cocoa may improve fatigue in people with multiple sclerosis.Sep 30, 2017

Free testosterone is significantly decreased in ALS, indicating that supplementation with testosterone may have a therapeutic role in ALS treatment. Mar 15, 2002

Genetically lowered 25OHD level is associated with an increase in the risk of MS in people of European descent.Jul 31, 2015

Geomagnetic and solar activity may represent an environmental health risk factor for multiple sclerosis.Jun 30, 2016

Glutamate levels may contribute to the pathogenesis of ALS.Feb 01, 2010

Gluten sensitivity is a clinically confirmed problem in multiple sclerosis.Sep 01, 2009

Guillain-Barre syndrome is often associated with the presence of anti-ganglioside antibodies, indicating it is an autoimmune neurological disorder.Jul 14, 2010

Hepatitis B vaccination coverage has fallen to beneath 30% in France due to concerns over safety.Nov 01, 2009

Hepatitis B vaccination is associated with a wide range of autoimmune diseases.Feb 01, 2006

Hepatitis B vaccination is associated with an increased risk of CNS inflammatory demyelination after 3 years of age.May 01, 2002

Hepatitis B vaccination may contribute to autoimmune demyelinating complications due to immunological cross-reactivity between Hepatitis B virus surface antigen and myelin basic protein.Sep 01, 2005

Hepatitis B vaccine is associated with an increased risk of multiple sclerosis. Sep 14, 2004

High dose vitamin D3 improves the inflammation/immune status in patients with multiple sclerosis. Jan 01, 2010

High homocysteine levels are associated with neurodegenerative conditions such as Parkinson's disease, ALS and progressive supranuclear palsy.Jul 01, 2010

High homocysteine levels may be associated with the pathogenesis of neurological disorders.Jan 01, 2010

High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis.Feb 12, 2019

Higher vitamin D levels are inversely correlated to lower incidence of multiple sclerosis in women.Aug 13, 2008

Highly significant increases compared with controls were found in patients with multiple sclerosis for IgA and IgG antibodies against gliadin and gluten and IgA antibodies against casein.Oct 01, 2004

Demyelinating Diseases

View the Evidence:
456 Abstracts with Demyelinating Diseases Research