Diabetic Complications

Name	AC	CK
Curcumin	44	97
Vitamin D	10	67
Omega-3 Fatty Acids	5	44
Alpha-Lipoic Acid	9	42
Cinnamon	7	42
Ginger	14	42
Carnitine	4	40
Magnesium	4	40
Nigella sativa (aka Black Seed)	12	40
Vitamin C	8	39
Resveratrol	22	38
Berberine	12	33
Flavonoids	9	32
Astaxanthin	17	31
Sesame Seed Oil	2	30
Vitamin B-12	3	30
Ginsenosides	14	26
Astragaloside	14	25
Polyphenols	9	24
Quercetin	8	23
B-complex	2	20
Benfotiamine	2	20
Fish	1	20
Hibiscus	2	20
Soy Protein	2	20
Thiamine (B-1)	2	20
EGCG (Epigallocatechin gallate)	11	18
Bee Propolis	4	17
Coenzyme Q10	5	17
Puerarin	9	17
Thymoquinone	10	17
Dates	4	16
Genistein	10	16
Gingerol	7	16
Grape Seed Extract	8	16
Moringa oleifera	8	15
Citrus naringin	6	14
Garlic	6	14
Paeoniflorin	8	14
Cannabis	3	13
Cinnamaldehyde	6	13
Cannabidiol	7	12
Delta-tetrahydrocannabinol (THC)	2	12
Flaxseed	2	12
Green Tea	2	12
Honey	2	12
Pomegranate	7	12
Probiotics	2	12
Pycnogenol (Pine Bark)	2	12
Saffron	2	12
Taurine	2	12
Fucoidan	6	11
Naringenin	6	11
Nettle	6	11
Almond	1	10
Arginine	1	10
Ascorbyl Palmitate	1	10
Bay leaf	1	10
Bifidobacterium Bifidum	1	10
Biotin	1	10
Carnitine, Acetyl-L-	1	10
Chia	1	10
Chromium	1	10
Cocoa	2	10
Cranberry	1	10
Curcuminoids	1	10
Eicosapentaenoic acid (EPA)	1	10
Ellagic Acid	5	10
Homeopathic Medicine: All	1	10
Kanuka Honey	1	10
Kiwifruit	1	10
Lactobacillus Acidophilus	1	10
Lactobacillus casei	1	10
Oyster Mushroom	1	10
Red Yeast Rice	1	10
Rice Bran	1	10
Roselle	1	10
Selenium	1	10
Sesame Seeds	1	10
St. Johns Wort	5	10
Turmeric	1	10
Ubiquinol	1	10
Vitamin B-6	1	10
Fisetin	3	9
Luteolin	3	9
Mangiferin	5	9
NAC (N-acetyl-L-cysteine)	5	9
Rose	5	9
Sulforaphane	5	9
Anthocyanins	5	8
Banana	4	8
Crocin	4	8
Diosgenin	4	8
Fenugreek	5	8
Ginkgo biloba	4	8
Goji	4	8
Hibiscus sabdariffa	4	8
Lotus	3	8
Prunella vulgaris	3	8
Purslane	4	8
Thymol	3	8
Vitamin E	3	8
Melatonin	4	7
Pterostilbene	4	7
Royal Jelly	4	7
Asiatic Acid	3	6
Bael	3	6
Caffeic acid phenethyl ester	3	6
Chaga Mushroom (Inonotus obliquus)	3	6
Fig	2	6
Gamma-Linoleic Acid (GLA)	2	6
Gastrodin	2	6
Hesperidin	3	6
Lychee	3	6
Piperine	2	6
Rutin	3	6
Sesamol	3	6
Strawberry	3	6
Tanshinone IIA	4	6
6-Shogaol	3	5
Chrysin	3	5
Fish Oil	3	5
Gallic Acid	3	5
Nobiletin	3	5
Rooibos	3	5
Salvia miltiorrhiza	3	5
Acetyl-l-carnitine	1	4
Amla Fruit	2	4
Caffeic Acid	2	4
Cannabinoids	3	4
Carnosic Acid	2	4
Carnosine	1	4
Corn: Purple	2	4
Dill	2	4
Embelia ribes	1	4
False Black Pepper	2	4
Gotu Kola	2	4
Histidine	1	4
Peanut	2	4
Phloretin	2	4
Pomegranate Seed	2	4
Rosemaric Acid	2	4
Safranal	2	4
Sesamin	2	4
Spirulina	2	4
Stevia	2	4
Toona sinensis	2	4
Ursolic Acid	2	4
Water: Deep Sea	2	4
Zerumbone	2	4
Zinc	2	4
Apigenin	2	3
Bamboo	2	3
Bitter Apple	2	3
Bitter Melon	2	3
Lupeol	2	3
Lutein	2	3
Lycopene	2	3
Myricetin	2	3
Okra	2	3
Onion	2	3
Panax Notoginseng	2	3
Parthenolide	2	3
Urolithin A	2	3
Xanthohumol	2	3
Acai	1	2
Aduki bean	1	2
Allicin	1	2
Aloe Vera	1	2
Andrographis	1	2
Arctigenin	1	2
Artichoke	1	2
Bacopa	1	2
Basil	1	2
Beans: All	1	2
Bee Venom	1	2
Bergamot orange	1	2
Betanin	1	2
Bilberry	1	2
Black Raspberry Seed	1	2
Boron	1	2
Butyrate	1	2
Caraway	1	2
Carnosine	1	2
Carnosol	1	2
Chamomile	1	2
Chlorella (Algae)	1	2
Chokeberry	1	2
Citrus Peel	1	2
Clove	1	2
Coconut Water	1	2
Coffee	1	2
Cordyceps sinensis	1	2
Coriandrum sativum	1	2
Cumin	1	2
D-Limonene	1	2
Date Seeds	1	2
Diosmin	1	2
Echinacea	1	2
Elderberry	1	2
Eugenol	1	2
Ferulic acid	1	2
Frankincense	1	2
Geraniol	1	2
Ginseng (American)	1	2
Ginseng (Korean)	1	2
Hawthorn	1	2
Horse Chestnut	1	2
Horsetail	1	2
Huperzine	1	2
Inositol	1	2
Kaempferol	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Mango leaf	1	2
Manuka Honey	1	2
Marijuana	1	2
Milk Thistle	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Muskmelon	1	2
Oak	1	2
Oleuropein	1	2
Oregano	1	2
P-Coumaric Acid	1	2
Palash	1	2
Passion Flower	1	2
Perilla	1	2
Persimmon	1	2
Piceatannol	1	2
Pine Bark Extract	1	2
Pineapple	1	2
Potato	1	2
Prickly Pear Cactus	1	2
Psychedelics:All	1	2
Pterocarpus marsupium	1	2
Pumpkin	1	2
Punicalagin	1	2
Rehmannia	1	2
Rhubarb	1	2
Rice	1	2
Rose Hips	1	2
Silibinin	1	2
Spikenard	1	2
Stilbenes	1	2
Syrian rue	1	2
Taro	1	2
Tarragon	1	2
Tetrahydrocurcumin	1	2
Trigonelline	1	2
Vitamin A	1	2
Vitamin E: alpha tocopherol	1	2
Vitamin K	1	2
Vitamin K2	1	2
Vitexins	1	2
Walnut	1	2
Wheat Grass	1	2
White Mulberry	1	2
Agaricus brasiliensis	1	1
Apple Polyphenols	1	1
Artesunate	1	1
Baicalein	1	1
Betulinic acid	1	1
Broccoli Sprouts	1	1
Caffeine	1	1
Cannabigerol	1	1
Catechin	1	1
Chickpea	1	1
Crocetin	1	1
Cucumber	1	1
Delphinidin	1	1
Fermented Foods and Beverages	1	1
Graviola	1	1
Hibiscus rosa-sinensis	1	1
Isoliquiritigenin	1	1
Isothiocyanates	1	1
Mangosteen	1	1
Nutmeg	1	1
Plantago	1	1
Red Sage	1	1
Reishi Mushroom	1	1
Silver (nanoparticles)	1	1
Silymarin	1	1
Soy Sauce	1	1
Tangeretin	1	1
Theophylline	1	1
Zeaxanthin	1	1
Vanadium	1	0

Name	AC	CK
Glipizide	2	40
Sulfonylureas	3	40
Rosiglitazone (trade name Avandia)	3	31
Aspirin	2	30
Glibenclamide	2	30
Statin Drugs	3	23
Glyburide	1	20
Organochlorine pesticides	1	20
Persistent organic pollutants (POPs)	1	20
Pesticides	1	20
Fructose	2	12
Insulin	2	12
Bisphenol A	1	10
Metformin	1	10
Simvastatin	1	10
Alloxan	2	4
Atorvastatin	1	3
Pravastatin	1	3
Cadmium	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Sucrose	1	2
Wheat	1	2

Name	AC	CK
Acupuncture	6	60
Yoga	2	30
Laser Treatment: Low-Level	6	27
Hyperbaric Treatment	3	22
Dietary Modification: Vegetarian	1	20
Therapeutic Breathing	2	20
Transcutaneous electrical nerve stimulation (TENS)	1	20
Exercise	6	17
Acupressure	1	10
Aromatherapy	1	10
Deep Breathing	1	10
Dietary Modification: Low Carbohydrate	1	10
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Dietary Modification: Low Glycemic Diet	1	10
Dietary Modification: Mediterranean Diet	1	10
Dietary Modification: Paleolithic/Stone Age Diet	1	10
Fasting/Caloric Restriction	1	10
Hydrotherapy	1	10
Integrative Medicine	1	10
Laughter/Humor	1	10
Reflexology	1	10
Thermal Therapy: Far-Infrared	1	10
Whole-Body Vibration	1	10
Electroacupuncture	2	4
Exercise: Resistance Training	2	4
Exercise: Aerobic	1	2
Light-Emitting Diodes (LEDs) Therapy	1	2
Ozone Therapy	1	1

Name	AC	CK	Focus
Western Diet	1	2

[+]

There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.Jun 01, 2010

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2010 Jun;33(6):1224-9. Epub 2010 Mar 9. PMID: 20215447

Article Published Date : Jun 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Coronary Artery Disease, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2, Mortality: All-Cause

Problem Substances : Glipizide, Glyburide

Adverse Pharmacological Actions : Cardiotoxic

[+]

A systematic review and meta-analysis of Abelmoschus manihot for diabetic nephropathy.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:9679234. Epub 2019 Apr 18. PMID: 31118973

Click here to read the entire abstract

Pubmed Data : Diabetes Res Clin Pract. 2008 Dec;82(3):391-5. Epub 2008 Oct 21. PMID: 18945509

Article Published Date : Dec 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Coronary Artery Disease, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Glibenclamide, Glipizide

Adverse Pharmacological Actions : Cardiotoxic

[+]

Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease.Nov 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Additional Keywords : Drug: Glibenclamide, Drug Synergy

[+]

3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes.Feb 09, 2015

Click here to read the entire abstract

Pubmed Data : J Complement Integr Med. 2015 Feb 10. Epub 2015 Feb 10. PMID: 25719344

Article Published Date : Feb 09, 2015

Study Type : Human Study

Additional Links

Substances : Ginger

Diseases : C-Reactive Protein (CRP), Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Hyperglycemia, Insulin Resistance

Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers

[+]

A combination of quercetin, ascorbyl palmitate and vitamin D appears to safely offer relief of symptomatic diabetic neuropathy.Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : J Diabetes Complications. 2005 Sep-Oct;19(5):247-53. PMID: 16112498

Pubmed Data : Nutr Metab (Lond). 2009;6:21. Epub 2009 May 6. PMID: 19419563

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2

[+]

A pilot study indicated that applying kiwifruit on neuropathic diabetic foot ulcers led to a significant reduction in the size of the foot ulcers and faster wound healing.May 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Res Med Sci. 2014 Jun ;19(6):520-4. PMID: 25197293

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2009 Sep;15(9):1027-32. PMID: 19757980

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Diabetic Neuropathies

Therapeutic Actions : Acupressure

[+]

Acupuncture could bring benefit as an additional treatment for people with diabetic painful neuropathy.May 31, 2014

Click here to read the entire abstract

Pubmed Data : Acupunct Med. 2014 Jun ;32(3):242-9. Epub 2014 Mar 21. PMID: 24657491

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2020 Feb ;19(2):1468-1471. Epub 2019 Dec 27. PMID: 32010324

Pubmed Data : J Pediatr Endocrinol Metab. 2015 Aug 15. Epub 2015 Aug 15. PMID: 26352081

Article Published Date : Aug 14, 2015

Study Type : Human Study

Additional Links

Diseases : Diabetic Complications

Therapeutic Actions : Aromatherapy

Pharmacological Actions : Antinoceceptive

Additional Keywords : Essential Oils

[+]

Ascorbic acid with metformin is more effective against reducing risks for diabetes related long-term complications.Aug 13, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : J Clin Biochem Nutr. 2009 Jan;44(1):52-6. Epub 2008 Dec 27. PMID: 19177188

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Substances : Bay leaf

Diseases : Cholesterol: LDL/HDL ratio, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2, Triglycerides: Elevated

Pharmacological Actions : Hypoglycemic Agents

[+]

Benfotiamine inhibits oxidative stress with type 2 diabetes.Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2006 Sep;29(9):2064-71. PMID: 16936154

Pubmed Data : Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):344-54. PMID: 21675032

Article Published Date : Oct 01, 2010

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2007 Nov;30(11):2804-10. Epub 2007 Aug 8. PMID: 17686832

Article Published Date : Nov 01, 2007

Study Type : Human Study

Additional Links

Substances : Chia

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

[+]

Cocoa flavanols intake benefits cognitive function in type 1 diabetes.Jun 24, 2019

Click here to read the entire abstract

Pubmed Data : Psychopharmacology (Berl). 2019 Jun 25. Epub 2019 Jun 25. PMID: 31236643

Efficacy of alogliptin combined with motor imagery under hyperbaric oxygen in diabetic nephropathy with silent cerebral infarction.Oct 31, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Rep. 2017 Nov ;7(5):407-415. Epub 2017 Sep 14. PMID: 29181153

Article Published Date : Oct 31, 2017

Study Type : Human Study

Additional Links

Diseases : Cerebral Ischemia, Diabetic Nephropathy

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Neuroprotective Agents

[+]

Eicosapentaenoic acid (EPA) reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Mar 01, 2007

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2007 Mar;191(1):162-7. Epub 2006 Apr 17. PMID: 16616147

Article Published Date : Mar 01, 2007

Study Type : Human Study

Additional Links

Substances : Eicosapentaenoic acid (EPA)

Diseases : Carotid Stenosis, Diabetes: Cardiovascular Illness

[+]

Glibenclamide in combination with metformin is associated with significantly higher mortality. Nov 01, 2006

Pubmed Data : Diabetologia. 2009 Feb;52(2):208-12. Epub 2008 Dec 5. PMID: 19057893

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Substances : Thiamine (B-1)

Diseases : Diabetes: Kidney Function , Diabetic Nephropathy, Microalbuminuria

[+]

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2012 Aug 8. Epub 2012 Aug 8. PMID: 22875226

Article Published Date : Aug 07, 2012

Study Type : Human Study

Additional Links

Diseases : Aortic Calcification, Arterial Calcification, Coronary Artery Disease, Diabetes: Cardiovascular Illness

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Cardiotoxic

[+]

Nigella sativa oil supplementation had a protective effect in diabetic nephropathy.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Saudi J Kidney Dis Transpl. 2017 Jan-Feb;28(1):9-14. PMID: 28098097

Pubmed Data : Mymensingh Med J. 2007 Jan;16(1):94-9. PMID: 17344789

Article Published Date : Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : Indian J Med Res. 2010 May;131:636-40. PMID: 20516534

Article Published Date : May 01, 2010

Study Type : Human Study

Additional Links

Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 2

Therapeutic Actions : Therapeutic Breathing, Yoga

[+]

Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Kidney Int. 2017 02 ;91(2):435-442. Epub 2016 Dec 4. PMID: 27927601

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Bifidobacterium Bifidum, Lactobacillus Acidophilus, Lactobacillus casei

Diseases : Diabetic Complications, Hemodialysis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

probiotic yogurt may be used as an alternative prevention approach and treatment method to control diabetic complications.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:843036. Epub 2014 Jan 9. PMID: 24527055

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Diseases : Diabetic Neuropathies

Therapeutic Actions : Reflexology

[+]

Selenium supplementation among diabetic nephropathy patients had favourable effects on serum MMP-2, plasma NO, TAC and GSH.Sep 19, 2016

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2016 Sep 20:1-7. Epub 2016 Sep 20. PMID: 27647263

Article Published Date : Sep 19, 2016

Study Type : Human Study

Additional Links

Substances : Selenium

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor

[+]

Serum vitamin D and diabetic foot complications.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : J Med Food. 2006 Fall;9(3):408-12. PMID: 17004907

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Substances : Sesame Seed Oil

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

[+]

The use of glyburide and/or metformin results in increased mortality in type 2 diabetics with coronary artery disease. Feb 01, 2001

Click here to read the entire abstract

Pubmed Data : Clin Cardiol. 2001 Feb;24(2):151-8. PMID: 11460818

Pubmed Data : Arzneimittelforschung. 1999 Apr;49(4):324-9. PMID: 10337451

Click here to read the entire abstract

Pubmed Data : Diabetes Metab Res Rev. 2016 May 7. Epub 2016 May 7. PMID: 27155442

Article Published Date : May 06, 2016

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathies, Vitamin D Deficiency

Additional Keywords : Increased Risk

[+]

Vitamin D deficiency is considered as a risk factor for diabetic retinopathy and hearing loss among diabetic patients.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2018 ;2018:2714590. Epub 2018 Jul 9. PMID: 30112372

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Diseases : Diabetic Complications, Diabetic Retinopathy, Hearing Loss, Vitamin D Deficiency

Additional Keywords : Risk Factors

[+]

Vitamin D deficiency is prevalent in patients with diabetic nephropathy and increases in severity with diabetic nephropathy progression.Mar 03, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):855-60. PMID: 15636309

Article Published Date : Jun 01, 2002

Study Type : Human Study

Additional Links

Diseases : Diabetes: Cardiovascular Illness, Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2

Therapeutic Actions : Yoga

[+]

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Click here to read the entire abstract

Pubmed Data : J Med Food. 2017 Jun 26. Epub 2017 Jun 26. PMID: 28650731

Article Published Date : Jun 25, 2017

Study Type : Human In Vitro

Additional Links

Substances : Fisetin, Luteolin

Diseases : Diabetic Complications, Hyperglycemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Naringin protects against high glucose-induced human endothelial cell injury.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Diabetes. 2010 Jul;59(7):1825-35. Epub 2010 Apr 27. PMID: 20424226

Article Published Date : Jul 01, 2010

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2010 Jul ;24(7):969-74. PMID: 19957251

Article Published Date : Jun 30, 2010

Study Type : Animal Study

Additional Links

Diseases : Cardiomyopathy, Diabetes: Cardiovascular Illness

Pharmacological Actions : Cardioprotective

[+]

[+]

6-shogaol may be of value in protection against diabetic complications in kidney and heart.Aug 31, 2018

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2018 Sep ;31(5(Supplementary)):2109-2117. PMID: 30393220

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Cardiomyopathy, Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.Sep 01, 2016

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2016 Sep 2:1-9. Epub 2016 Sep 2. PMID: 27875075

Article Published Date : Sep 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chem Biol Interact. 2016 Feb 5 ;245:1-11. Epub 2015 Dec 8. PMID: 26680107

Article Published Date : Feb 04, 2016

Study Type : Animal Study

Additional Links

Substances : Thymol

Diseases : Diabetic Nephropathy, High Fat Diet

Pharmacological Actions : Renoprotective, Vascular Endothelial Growth Factor Inhibitors

[+]

Anti Therapeutic Actions : Western Diet

[+]

Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway.Mar 01, 2020

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2020 Mar 2:173052. Epub 2020 Mar 2. PMID: 32135124

Article Published Date : Mar 01, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Allicin

Diseases : Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation

[+]

Allicin delays the progression of diabetic nephropathy through antioxidant and anti-inflammatory mechanisms.Oct 10, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2018 Oct 11 ;19(10). Epub 2018 Oct 11. PMID: 30314265

Click here to read the entire abstract

Pubmed Data : Diabetes Res Clin Pract. 1999 Sep;45(2-3):137-46. PMID: 10588366

Article Published Date : Sep 01, 1999

Study Type : Animal Study

Additional Links

Substances : Acetyl-l-carnitine, Alpha-Lipoic Acid, Gamma-Linoleic Acid (GLA) , Vitamin E

Diseases : Diabetes: Cardiovascular Illness, Diabetic Neuropathies

Pharmacological Actions : Antioxidants

[+]

Antioxidative effect of flavonoid naringenin in the lenses of type 1 diabetic rats.Nov 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:974-984. Epub 2018 Sep 27. PMID: 30372909

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Diabetes: Cataract, Diabetes: Oxidative Stress, Diabetes Mellitus: Type 1

Pharmacological Actions : Antioxidants

[+]

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

[+]

Astaxanthin had an anti-depressant effect on diabetic mice.Dec 21, 2016

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Pubmed Data : Brain Res. 2016 Dec 22. Epub 2016 Dec 22. PMID: 28017669

Article Published Date : Dec 21, 2016

Study Type : Animal Study

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Substances : Astaxanthin

Diseases : Brain Inflammation , Depression, Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Prophylactic Agents

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Astaxanthin has an inhibitory effect on oxidative stress in diabetic rats. Jul 01, 2008

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Pubmed Data : Int J Vitam Nutr Res. 2008 Jul-Sep;78(4-5):175-82. PMID: 19326340

Article Published Date : Jul 01, 2008

Study Type : Animal Study

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Substances : Astaxanthin

Diseases : Cataract, Diabetes: Oxidative Stress, Diabetes Mellitus: Type 1, Diabetic Complications, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Proanthocyanidins

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Additional Keywords : Antioxidants, Astaxanthin, Diabetic Nephropathy, Kidney Fibrosis, Nrf2 activation, Renoprotective

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Astaxanthin treatment partially attenuates some detrimental effect of diabetes.May 31, 2016

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Pubmed Data : Drug Des Devel Ther. 2018 ;12:2785-2793. Epub 2018 Sep 6. PMID: 30233141

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Astragaloside

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic

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Astragaloside IV attenuates podocyte apoptosis mediated by endoplasmic reticulum stress in diabetic nephropathy.Dec 31, 2015

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Pubmed Data : Ren Fail. 2016 Oct ;38(9):1528-1544. Epub 2016 Oct 26. PMID: 27784187

Article Published Date : Sep 30, 2016

Study Type : Animal Study

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Substances : Bacopa

Diseases : Advanced Glycation End products (AGE), Diabetic Nephropathy

Pharmacological Actions : Anti-Glycation Agents, Renoprotective

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Bamboo leaf extract treatment may be a potential promising therapy for diabetic nephropathy.Mar 26, 2017

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Pubmed Data : Int J Biol Macromol. 2017 Mar 27. Epub 2017 Mar 27. PMID: 28359892

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Pharmacol. 2016 ;7:360. Epub 2016 Aug 13. PMID: 27790139

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Garlic, Resveratrol

Diseases : Diabetes Mellitus: Type 1, Diabetic Complications

Pharmacological Actions : Antioxidants, Hepatoprotective, Pancreato Protective Agents

Additional Keywords : Superiority of Natural Substances versus Drugs

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Both topical and systemic administration of NAC improved wound healing in a diabetic rat model.Dec 31, 2018

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Pubmed Data : Pharm Biol. 2014 Aug ;52(8):1021-7. Epub 2014 Mar 12. PMID: 24617860

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Pubmed Data : Indian J Clin Biochem. 2019 Jul ;34(3):296-303. Epub 2018 Feb 26. PMID: 31391719

Article Published Date : Jun 30, 2019

Study Type : Animal Study

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Substances : Caffeic Acid

Diseases : Diabetic Nephropathy

Pharmacological Actions : MicroRNA modulator, Renoprotective

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Caffeic acid phenethyl ester should be considered in the prevention of oxidative stress in diabetic liver.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bratisl Lek Listy. 2016 ;117(5):276-82. PMID: 27215964

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Caffeic acid phenethyl ester

Diseases : Diabetic Complications, Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants

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Caffeic acid phenetyl ester, a compound found within bee propolis, protects the diabetic heart against oxidative stress. Feb 01, 2005

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Pubmed Data : Clin Biochem. 2005 Feb;38(2):191-6. PMID: 15642285

Article Published Date : Feb 01, 2005

Study Type : Animal Study

Additional Links

Substances : Bee Propolis, Caffeic acid phenethyl ester

Diseases : Diabetes: Cardiovascular Illness, Oxidative Stress

Pharmacological Actions : Antioxidants

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Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.Dec 14, 2010

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Pubmed Data : J Am Coll Cardiol. 2010 Dec 14;56(25):2115-25. PMID: 21144973

Article Published Date : Dec 14, 2010

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Cardiomyopathy, Cardiovascular Diseases, Diabetes: Cardiovascular Illness

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Chronic administration of N. sativa seed extract has a significant hypoglycemic effect.Dec 31, 2015

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Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):67-76. PMID: 27247923

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Diabetic Complications, Endothelial Dysfunction

Pharmacological Actions : Hypoglycemic Agents

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Chronic running exercise alleviates early progression of nephropathy.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(9):e0138037. Epub 2015 Sep 17. PMID: 26379244

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Pubmed Data : J Med Food. 2015 Feb 4. Epub 2015 Feb 4. PMID: 25651375

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Pubmed Data : Neurosci Lett. 2008 Aug 29;441(3):302-6. Epub 2008 Jun 22. PMID: 18586072

Article Published Date : Aug 29, 2008

Study Type : Animal Study

Additional Links

Substances : Coffee, Trigonelline

Diseases : Auditory neuropathy , Diabetic Neuropathies

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Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice.Feb 21, 2019

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Pubmed Data : Food Chem Toxicol. 2019 Feb 22. Epub 2019 Feb 22. PMID: 30802477

Article Published Date : Feb 21, 2019

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid, Carnosine

Diseases : Diabetic Complications, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

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Combined ginger and cinnamon have significant beneficial effects on the sperm viability, motility, and serum total testosterone, LH,FSH and serum anti-oxidants levelDec 31, 2013

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Pubmed Data : Afr J Tradit Complement Altern Med. 2014 ;11(4):1-8. Epub 2014 Jun 4. PMID: 25392573

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Cinnamon, Ginger

Diseases : Diabetic Complications

Pharmacological Actions : Antioxidants, Spermatogenic

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View the Evidence: 928 Abstracts with Diabetic Complications Research

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There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.Jun 01, 2010

A systematic review and meta-analysis of Abelmoschus manihot for diabetic nephropathy.Dec 31, 2018

Aspirin does not prevent cardiovascular events in diabetes mellitus.Jun 01, 2010

Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.Apr 15, 2003

Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.Dec 01, 2008

Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease.Nov 30, 2020

Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes.Jun 14, 2007

Sulfonylureas are associated with an increased risk of adverse cardiovascular events in type 2 diabetic patients.Jun 01, 2009

TENS therapy may be an effective and safe strategy in treatment of symptomatic diabetic peripheral neuropathy.Jul 01, 2010

There is significant evidence demonstrating that Qigong may be beneficial in type 2 diabetes. Sep 01, 2005

Vegetarian dietary patterns improve cardiometabolic risk factors in diabetes.Jun 12, 2018

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.Nov 01, 2010

The consumption of omega-3 fatty acid supplements decreases homocysteine levels in diabetic patients.Jun 01, 2010

"Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus."Jun 01, 2011

3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes.Feb 09, 2015

A combination of quercetin, ascorbyl palmitate and vitamin D appears to safely offer relief of symptomatic diabetic neuropathy.Sep 01, 2005

A flaxseed-derived lignan supplement may reduce C-reactive protein in type 2 diabetics. Apr 01, 2009

A low carbohydrate diet has the potential to reduce abdominal fat and adverse lipid changes in patients with type 2 diabetes.Jan 01, 2011

A low glycemic index diet improves glycation in patients with type 2 diabetes.Jun 01, 2010

A low-carbohydrate diet is as effective as insulin therapy in faciliating glycemic control in patients with severe type 2 diabetes. Jan 01, 2009

A pilot study indicated that applying kiwifruit on neuropathic diabetic foot ulcers led to a significant reduction in the size of the foot ulcers and faster wound healing.May 31, 2014

A tea made from Roselle (Hibiscus sabdariffa) improves blood lipid profiles in patients with diabetes. Aug 01, 2009

Acetyl-l-carnitine is effective and well tolerated in improving neurophysiological parameters and in reducing pain in patients with diabetic neuropathy. Jan 01, 2002

Acetyl-l-carnitine shows promise in the treatment of diabetic peripheral neuropathy. Jan 01, 2007

Acupressure therapy inhibits the development of diabetic complications in patients with type 2 diabetes. Sep 01, 2009

Acupuncture could bring benefit as an additional treatment for people with diabetic painful neuropathy.May 31, 2014

Acupuncture has therapeutic effects on diabetic neuropathies. Mar 01, 2006

Acupuncture has therapeutic value in the treatment of diabetic peripheral neuropathy. Jun 01, 2010

Acupuncture may be clinically useful for the radical treatment of diabetic bladder dysfunction. Aug 01, 2009

Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes.Jan 31, 2020

Almond ingestion at mealtime reduces postprandial glycemia and chronic ingestion reduces hemoglobin A(1c) in individuals with well-controlled type 2 diabetes mellitus.Apr 11, 2011

Alpha Lipoic Acid has therapeutic benefits in the treatment of diabetic neuropathy - Article 1Jan 01, 2008

Aromatherapy decreased the autonomic response to a painful stimulus.Aug 14, 2015

Ascorbic acid with metformin is more effective against reducing risks for diabetes related long-term complications.Aug 13, 2017

Aspirin increases mortality in diabetic patients without cardiovascular disease. Dec 01, 2009

Association of vitamin D deficiency and degree of coronary artery disease in cardiac patients with type 2 diabetes.Dec 31, 2016

Bay leaves improve glucose and lipid profile of people with type 2 diabetes.Jan 01, 2009

Benfotiamine inhibits oxidative stress with type 2 diabetes.Sep 01, 2006

Benfotiamine reduces polyneuropathy symptoms. - Article 2Feb 01, 2005

Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

Biotin improves diabetic peripheral neuropathy. Jan 01, 1990

Black cumin seeds have significant anti-diabetic effects in type 2 diabetics. Oct 01, 2010

C-reactive protein is a strong independent predictor of death in type 2 diabetes: association with multiple facets of the metabolic syndrome.Mar 01, 2006

C-reactive protein more than LDL determines cardiovascular events and mortality in hemodialysis patients with type 2 diabetes mellitus.Nov 01, 2009

Chia seed (S. hispanica) supplementation attenuates cardiovascular risk factors while maintaining good glycemic and lipid control in people with well-controlled type 2 diabetes. Nov 01, 2007

Cocoa flavanols intake benefits cognitive function in type 1 diabetes.Jun 24, 2019

Cocoa flavanols reverse vascular dysfunction in diabetics.Jun 01, 2009

Combined therapy regulates the inflammatory process and oxidative stress and contributes to immune protection on patients with T2D.May 07, 2018

Compared to placebo, the prepared saffron gel could significantly improve erectile dysfunction in diabetic patientsMay 05, 2015

Complementary homeopathic therapy of diabetic neuropathy was feasible and promising effects in symptom scores and cost savings were observed.Dec 31, 2008

CoQ10 supplementation for 12 weeks among DN patients had favorable effects on glucose metabolism, MDA, and AGEs levels.Nov 06, 2017

Cranberry extract has a favorble effect on blood lipid profiles in patients with type 2 diabetes. Dec 01, 2008

Curcumin as a major active component of turmeric attenuates proteinuria in patients with overt diabetic nephropathy.Dec 31, 2018

Date consumption (and mainly the Hallawi variety) by healthy subjects, despite their high sugar content, demonstrates beneficial effects on serum triacylglycerol and oxidative stress and does not worsen serum glucose and lipid/lipoprotein pattern. Sep 09, 2009

Early hyperbaric oxygen therapy may improve the long term neurological consequences of diabetic patients suffering from hemorrhagic stroke.Feb 22, 2017

Effect of an aqueous extract of Terminalia chebula on endothelial dysfunction, systemic inflammation, and lipid profile in type 2 diabetes mellitus.Jul 01, 2020

Efficacy of alogliptin combined with motor imagery under hyperbaric oxygen in diabetic nephropathy with silent cerebral infarction.Oct 31, 2017

Eicosapentaenoic acid (EPA) reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Mar 01, 2007

Glibenclamide in combination with metformin is associated with significantly higher mortality. Nov 01, 2006

Green tea polyphenols reduces albuminuria in diabetic patients receiving the maximum recommended dose of RAS.Dec 31, 2015

Hibiscus infusion had positive effects on Blood Pressure in type 2 diabetics.Aug 07, 2008

High dose magnesium may improve control and/or prevent complications in type 2 diabetic patients. May 01, 1998

High doses of fructose raise the BP and cause the features of metabolic syndrome. Mar 01, 2010

High-dose thiamine therapy produced a regression of urinary albumin excretion in type 2 diabetic patients with microalbuminuria.Feb 01, 2009

Hypomagnesaemia was significantly associated with higher prevalence of diabetic nephropathy.Jul 13, 2016

Inhaled cannabis demonstrated a dose dependent reduction in diabetic peripheral neuropathy pain in patients with treatment refractory pain.Jun 30, 2015

Kanuka honey was associated with a reduction in weight and improvements in lipid parameters and reduced systolic blood pressure in individuals with type 2 diabetes.May 18, 2015

L-arginine protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.May 01, 2009

L-carnitine lowers lipoprotein (a) serum levels in patients with type 2 diabetes, whereas simvastatin increases them. Oct 01, 2006

L-carnitine significantly lowered the plasma Lp(a) level compared with placebo in selected hypercholesterolemic patients with newly diagnosed type 2 DM.May 01, 2003

L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes.Jan 01, 2009

Diabetic Complications

View the Evidence:
928 Abstracts with Diabetic Complications Research