Diabetic Neuropathy

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66 Substances Researched for Diabetic Neuropathy
NameACCKFocus
Alpha-Lipoic Acid634Locked
Bitter Apple212Locked
Vitamin B-12211Locked
Carnitine110Locked
Chamomile110Locked
Eucalyptus110Locked
Geranium110Locked
Gotu Kola110Locked
Lavender: Essential Oil110Locked
NAC (N-acetyl-L-cysteine)110Locked
Rosemary: Essential Oil110Locked
Vitamin D110Locked
Vitamin E110Locked
Berberine47Locked
Naringenin 24Locked
Tanshinone IIA24Locked
Vitamin C24Locked
Resveratrol23Locked
6-Shogaol12Locked
Artemisinin12Locked
Arugula12Locked
B-complex12Locked
Banana Peel12Locked
Biochanin A12Locked
Cannabidiol12Locked
Chrysin12Locked
Combretum fragrans12Locked
Curcumin12Locked
Deguelin12Locked
Diosmin 12Locked
Feverfew12Locked
Fig12Locked
Formononetin12Locked
Gastrodin12Locked
Ginger12Locked
Grape Seed Extract12Locked
Gymnema Sylvestre12Locked
Isoliquiritigenin12Locked
Kaempferol12Locked
Lion's Mane (Hericium Erinaceus)12Locked
Lycopene12Locked
Moringa oleifera12Locked
Nettle12Locked
Nigella sativa (aka Black Seed)12Locked
Phloretin12Locked
Rhubarb12Locked
Rosemary12Locked
Saffron12Locked
Spirulina12Locked
St. Johns Wort12Locked
Stilbenes12Locked
Thymoquinone12Locked
Vitamin E: alpha tocopherol12Locked
Walnut12Locked
Cinnamaldehyde11Locked
Dogwood11Locked
Folic Acid 11Locked
Hirudin (from Medicinal Leaches)11Locked
Jujube11Locked
Kiwifruit11Locked
Myo-inositol11Locked
Quercetin11Locked
Thiamine (B-1) 11Locked
Vitamin B-611Locked
Vitamin B1211Locked
Vitamin B12: methylcobalamin 11Locked
2 Problem Substances Researched for Diabetic Neuropathy
NameACCKFocus
Alloxan24Locked
Rosiglitazone (trade name Avandia)12Locked
6 Therapeutic Actions Researched for Diabetic Neuropathy
NameACCKFocus
Exercise120Locked
Aromatherapy Massage110Locked
Meditation 110Locked
Mindfullness Training110Locked
Yoga110Locked
Yogic Technique: Sudarshan kriya110Locked

View the Evidence:
69 Abstracts with Diabetic Neuropathy Research

[+]

Proprioceptive exercise may improve functional capacity, anxiety, and depression in diabetic neuropathy patients.Apr 15, 2020

Pubmed Data : Clin Rheumatol. 2020 Apr 16. Epub 2020 Apr 16. PMID: 32300897
Article Published Date : Apr 15, 2020
Study Type : Meta Analysis
Additional Links
Diseases : Anxiety, Depression, Diabetic Neuropathy
Therapeutic Actions : Exercise
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Reduced serum levels of folate and vitamin B12 were found in Chinese patients with T2DM and diabetic peripheral neuropathy.Jan 08, 2017

Pubmed Data : Mol Cell Endocrinol. 2017 Jan 9. Epub 2017 Jan 9. PMID: 28081987
Article Published Date : Jan 08, 2017
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy, Vitamin B 12 Deficiency
[+]

7,8-dihydroxyflavone protects high glucose-damaged neuronal cells against oxidative stress.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2019 01 1 ;27(1):85-91. PMID: 30481956
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Alpha lipoic has significant therapeutic value in the treatment of diabetic neuropathy. Nov 01, 2008

Pubmed Data : Bosn J Basic Med Sci. 2008 Nov;8(4):341-5. PMID: 19125705
Article Published Date : Nov 01, 2008
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy, Polyneuropathies
[+]

Application of a topical formulation of C. colocynthis fruit extract can decrease pain in patients with PDPN.Mar 19, 2015

Pubmed Data : J Diabetes. 2015 Mar 20. Epub 2015 Mar 20. PMID: 25800045
Article Published Date : Mar 19, 2015
Study Type : Human Study
Additional Links
Substances : Bitter Apple
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Aromatherapy massage was beneficial for neuropathic pain and quality of life in diabetic patients.Jun 30, 2017

Pubmed Data : J Nurs Scholarsh. 2017 Jul ;49(4):379-388. Epub 2017 Jun 12. PMID: 28605119
Article Published Date : Jun 30, 2017
Study Type : Human Study
Additional Links
Substances : Chamomile, Eucalyptus, Geranium, Lavender: Essential Oil, Rosemary: Essential Oil
Diseases : Diabetic Neuropathy
Therapeutic Actions : Aromatherapy Massage
Additional Keywords : Essential Oils
[+]

Centella asiatica triterpenes are beneficial for diabetic neuropathy.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Esper Dermatol. 2018 Jun ;20(2 Suppl 1):12-22. PMID: 31080345
Article Published Date : May 31, 2018
Study Type : Human Study
Additional Links
Substances : Gotu Kola
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy.Oct 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Oct 23 ;12(11). Epub 2020 Oct 23. PMID: 33114210
Article Published Date : Oct 22, 2020
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid, Carnitine, Vitamin B-12
Diseases : Diabetic Neuropathy
Pharmacological Actions : Renoprotective
Additional Keywords : Risk Reduction
[+]

Integrative therapies such as mindfulness meditation can be part of a comprehensive pain management plan.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Evid Based Integr Med. 2019 Jan-Dec;24:2515690X19876599. PMID: 31544476
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Diabetic Neuropathy
Therapeutic Actions : Meditation , Mindfullness Training
Pharmacological Actions : Analgesics
Additional Keywords : Medication Reduction
[+]

N-acetylcysteine may alleviate painful symptoms of diabetic neuropathy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pain Res. 2019 ;12:3147-3159. Epub 2019 Nov 19. PMID: 31819599
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Oral 600mg alpha-lipoic acid twice daily treatment for diabetic peripheral neuropathy over 6 months is effective, safe and tolerable.May 04, 2020

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2020 May 5. Epub 2020 May 5. PMID: 32370731
Article Published Date : May 04, 2020
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathy, Peripheral Neuropathies
Pharmacological Actions : Neuroprotective Agents
[+]

This trial points towards the beneficial effect of yogic breathing program in preventing progression of cardiac neuropathy.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Endocrinol Metab. 2014 Jul ;18(4):582-4. PMID: 25143922
Article Published Date : Jun 30, 2014
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
Therapeutic Actions : Yoga, Yogic Technique: Sudarshan kriya
Pharmacological Actions : Hypoglycemic Agents
[+]

Vitamin D supplementations improve peripheral diabetic neuropathy.Jan 31, 2019

Pubmed Data : Diabetes Metab Syndr. 2019 Jan - Feb;13(1):890-893. Epub 2018 Dec 20. PMID: 30641826
Article Published Date : Jan 31, 2019
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
[+]

Vitamin-E was found to be effective in reducing pain score in diabetic neuropathy patients.Jan 31, 2014

Pubmed Data : Pharmacol Rep. 2014 Feb ;66(1):44-8. Epub 2014 Jan 30. PMID: 24905305
Article Published Date : Jan 31, 2014
Study Type : Human Study
Additional Links
Substances : Vitamin E
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics, Antioxidants
[+]

Antinociceptive effect of chrysin in diabetic neuropathy and formalin-induced pain models.May 24, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anim Cells Syst (Seoul). 2020 May 25 ;24(3):143-150. Epub 2020 May 25. PMID: 33209194
Article Published Date : May 24, 2020
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antinoceceptive
[+]

Alpha-lipoic acid has a protective effect on peripheral neuronal cell damage generated with diabetic neuropathy.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Arch. 2018 Jun ;72(3):178-181. PMID: 30061762
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Jul-Sep;17(3):1559325819862449. Epub 2019 Jul 16. PMID: 31360147
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Analysis showed that naringenin corrected the altered sciatic changes in diabetic animals.Sep 30, 2015

Pubmed Data : Neurol Res. 2015 Oct ;37(10):924-33. Epub 2015 Jul 17. PMID: 26187552
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Diabetic Neuropathy, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy.May 31, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Jun ;392(6):697-713. Epub 2019 Feb 13. PMID: 30759263
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Combretum fragrans
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antidepressive Agents, Antinoceceptive , Antioxidants, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

B vitamins alleviate indices of neuropathic pain in diabetic rats. Jun 10, 2009

Pubmed Data : Eur J Pharmacol. 2009 Jun 10;612(1-3):41-7. Epub 2009 Apr 23. PMID: 19393643
Article Published Date : Jun 10, 2009
Study Type : Animal Study
Additional Links
Substances : B-complex
Diseases : Diabetic Neuropathy
[+]

Berberine has a beneficial effect against diabetic neuropathy by improving micropathology and increasing neuritin expression.Feb 02, 2016

Pubmed Data : Eur J Pharmacol. 2016 Feb 3. Epub 2016 Feb 3. PMID: 26849937
Article Published Date : Feb 02, 2016
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Neuropathy
Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents
[+]

Berberine is a potential therapeutic alleviating diabetes and diabetic neuropathic painMay 11, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 May 12. Epub 2019 May 12. PMID: 31079200
Article Published Date : May 11, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin-A attenuates neuropathic pain in diabetic rats.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ayurveda Integr Med. 2016 Oct - Dec;7(4):231-237. Epub 2016 Nov 25. PMID: 27890700
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabeties. Mar 17, 2019

Pubmed Data : Brain Res. 2019 Mar 18. Epub 2019 Mar 18. PMID: 30898678
Article Published Date : Mar 17, 2019
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Allodynia, Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Curcumin has been demonstrated to effectively prevent or ameliorate diabetic mellitus and its complications including diabetic neuropathic pain.Aug 13, 2015

Pubmed Data : Neurosci Lett. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26282904
Article Published Date : Aug 13, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Deguelin ameliorates diabetic neuropathy by decreasing oxidative stress and plasma glucose levels.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;48(3):1164-1176. Epub 2018 Jul 25. PMID: 30045011
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Deguelin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Nrf2 activation
[+]

E. sativa might be beneficial in chronic diabetes in ameliorating the progression of diabetic neuropathy.Jul 31, 2018

Pubmed Data : Inflammopharmacology. 2018 Aug ;26(4):993-1003. Epub 2017 Nov 20. PMID: 29159712
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Arugula, Kaempferol
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antinoceceptive
Additional Keywords : Plant Extracts
[+]

Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy.Dec 31, 2019

Pubmed Data : J Integr Med. 2020 Jan ;18(1):59-67. Epub 2019 Dec 6. PMID: 31874814
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Bitter Apple
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
[+]

Ficus racemosa exhibits protective effects by reducing complications of diabetic neuropathy with neurodegeneration (DNN).Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharmacol. 2015 Nov-Dec;47(6):610-5. PMID: 26729951
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Fig
Diseases : Diabetic Complications, Diabetic Neuropathy
Pharmacological Actions : Hypoglycemic Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Formononetin ameliorates diabetic neuropathy.May 26, 2020

Pubmed Data : Chem Biodivers. 2020 May 27. Epub 2020 May 27. PMID: 32459048
Article Published Date : May 26, 2020
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
Pharmacological Actions : Renoprotective, SIRT1 Activator
[+]

Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(6):e39647. Epub 2012 Jun 25. PMID: 22761855
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Diabetic Neuropathy, Hyperalgesia
Pharmacological Actions : Analgesics
[+]

Ginger extracts and its compound, 6-shogaol could reduce pain symptoms in painful diabetic neuropathy.Nov 15, 2019

Pubmed Data : J Ethnopharmacol. 2019 Nov 16. Epub 2019 Nov 16. PMID: 31743763
Article Published Date : Nov 15, 2019
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol, Ginger
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Grape seed extract has a therapeutic effect on oxidation-associated nerve damage in diabetic rat.s Aug 01, 2008

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):321-8. PMID: 18797155
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Diabetic Neuropathy
[+]

Gymnema sylvestre extract application may be useful for the treatment of neuropathy in patients with chronic diabetes.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 May ;9(5):1670-1678. Epub 2015 Feb 20. PMID: 26136876
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Gymnema Sylvestre
Diseases : Diabetes Mellitus: Type 1, Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Hericium erinaceus treatment along with the antioxidant activity could be the probable way by which it had alleviated diabetic neuropathy.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:595480. Epub 2015 Apr 16. PMID: 25960754
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics, Antioxidants
Problem Substances : Alloxan
[+]

Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.Aug 31, 2017

Pubmed Data : J Nutr Biochem. 2017 Sep ;47:41-52. Epub 2017 May 11. PMID: 28528294
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Juglans regia leaf extract exert preventive and curative effects against STZ-induced diabetic neuropathy.Oct 01, 2017

Pubmed Data : BMC Complement Altern Med. 2017 Oct 2 ;17(1):476. Epub 2017 Oct 2. PMID: 28969623
Article Published Date : Oct 01, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Moringa oleifera has neuroprotective effects in diabetic neuropathic pain model.Dec 11, 2017

Pubmed Data : Chin J Integr Med. 2017 Dec 12. Epub 2017 Dec 12. PMID: 29234979
Article Published Date : Dec 11, 2017
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Neuroprotective Agents
[+]

Musa acuminata possess antidiabetic potential by reducing plasma glucose.Nov 04, 2019

Pubmed Data : Arch Physiol Biochem. 2019 Nov 5:1-13. Epub 2019 Nov 5. PMID: 31687854
Article Published Date : Nov 04, 2019
Study Type : Animal Study
Additional Links
Substances : Banana Peel
Diseases : Diabetic Complications, Diabetic Neuropathy, Dyslipidemias, Nephropathy
Pharmacological Actions : Hypoglycemic Agents
[+]

Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels.May 12, 2020

Pubmed Data : Food Funct. 2020 May 13. Epub 2020 May 13. PMID: 32400767
Article Published Date : May 12, 2020
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Nettle showed results comparable to rosiglitazone in reversing the long standing diabetes induced complications.Sep 26, 2013

Pubmed Data : Neurosci Lett. 2013 Sep 27 ;552:114-9. Epub 2013 Jul 31. PMID: 23916662
Article Published Date : Sep 26, 2013
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Diabetic Neuropathy, Memory Disorders
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Natural Substances Versus Drugs, Phytotherapy, Plant Extracts
Problem Substances : Rosiglitazone (trade name Avandia)
[+]

Neuroprotective and antinociceptive effects of rosemary extract in rats with painful diabetic neuropathy.May 11, 2018

Pubmed Data : J Physiol Sci. 2018 May 12. Epub 2018 May 12. PMID: 29754274
Article Published Date : May 11, 2018
Study Type : Animal Study
Additional Links
Substances : Rosemary
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Antinoceceptive , Neuroprotective Agents
[+]

Nigella sativa and thymoquinone could be a potential treatment against peripheral neuropathy.Dec 31, 2007

Pubmed Data : Neurochem Res. 2008 Jan ;33(1):87-96. Epub 2007 Aug 23. PMID: 17713854
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Phloretin could be a promising agent in the management of diabetic neuropathy.Apr 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 May ;101:821-832. Epub 2018 Mar 22. PMID: 29635891
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Phloretin
Diseases : Diabetic Neuropathy
[+]

Polyphenols can be promising in combating diabetic neuropathy-associated damaging pathways.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:9940169. Epub 2021 May 13. PMID: 34093722
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Curcumin, Kaempferol, Naringenin , Polyphenols, Quercetin, Resveratrol
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Pretreatment with the extract of Rheum ribes prior to alloxination, protected the mice from acquiring diabetes and diabetic neuropathy.Mar 25, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Pharm Res. 2014 Mar 26. Epub 2014 Mar 26. PMID: 24668155
Article Published Date : Mar 25, 2014
Study Type : Animal Study
Additional Links
Substances : Rhubarb
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Hypoglycemic Agents, Prophylactic Agents
Additional Keywords : Plant Extracts, Risk Reduction
Problem Substances : Alloxan
[+]

Protective effect of diosmin against diabetic neuropathy.Dec 31, 2013

Pubmed Data : J Integr Med. 2014 Jan ;12(1):35-41. PMID: 24461593
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Plant Extracts
[+]

Resveratrol has anti-inflammatory and neuroprotective properties in experimental diabetic neuropathy.Apr 02, 2010

Pubmed Data : Biochem Biophys Res Commun. 2010 Apr 2;394(2):360-5. Epub 2010 Mar 6. PMID: 20211601
Article Published Date : Apr 02, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Diabetic Neuropathy, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saffron extract may have a protective effect against diabetic neuropathy. Aug 27, 2009

Pubmed Data : Cell Mol Neurobiol. 2009 Aug 27. PMID: 19711182
Article Published Date : Aug 27, 2009
Study Type : Animal Study
Additional Links
Substances : Saffron
Diseases : Diabetic Neuropathy
[+]

Spirulina platensis could have a potential therapeutic role for managing induced painful diabetic neuropathy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pain Res. 2020 ;13:2289-2296. Epub 2020 Sep 15. PMID: 32982392
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antinoceceptive , Neuroprotective Agents
[+]

St. John's Wort and feverfew extracts may become new therapeutic perspectives for painful diabetic peripheral neuropathy. Dec 31, 2013

Pubmed Data : Fitoterapia. 2014 Jan ;92:23-33. Epub 2013 Oct 12. PMID: 24125916
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Feverfew, St. Johns Wort
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Tanshinone IIA could be a promising agent for painful diabetic neuropathy treatment.Oct 31, 2018

Pubmed Data : Exp Clin Endocrinol Diabetes. 2018 Nov ;126(10):632-639. Epub 2018 Jan 31. PMID: 29388177
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Neuropathy
[+]

The effects of lycopene on alloxan induced diabetic optic neuropathy.Feb 28, 2019

Pubmed Data : Cutan Ocul Toxicol. 2019 Mar ;38(1):88-92. Epub 2018 Nov 23. PMID: 30277087
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The potential roles of artemisinin and Its derivatives in the treatment of type 2 diabetes mellitus.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:585487. Epub 2020 Nov 26. PMID: 33381036
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Artemisinin
Diseases : Diabetes Mellitus: Type 2, Diabetic Complications, Diabetic Neuropathy, Diabetic Retinopathy
Pharmacological Actions : Cardioprotective, Neuroprotective Agents, Renoprotective
[+]

This study demonstrates that tanshinone IIA alleviates neuropathic pain.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kaohsiung J Med Sci. 2018 Aug ;34(8):428-437. Epub 2018 Apr 27. PMID: 30041760
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Neuropathy, Neuropathic Pain
Pharmacological Actions : Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Vitamin C ameliorated cardiac autonomic neuropathy in type 2 diabetic rats.Mar 14, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Diabetes. 2020 Mar 15 ;11(3):52-65. PMID: 32180894
Article Published Date : Mar 14, 2020
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Vitamins C and E provide synergistic neuroprotection in the jejunum in experimental diabetes.Sep 27, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pathophysiology. 2015 Sep 28. Epub 2015 Sep 28. PMID: 26433445
Article Published Date : Sep 27, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C, Vitamin E: alpha tocopherol
Diseases : Diabetes: Oxidative Stress, Diabetic Complications, Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

Alpha lipoic acid has therapeutic value in the treatment of diabetic neuropathy. Jan 01, 2009

Pubmed Data : Rev Diabet Stud. 2009;6(4):230-6. Epub 2009 Dec 30. PMID: 20043035
Article Published Date : Jan 01, 2009
Study Type : Commentary
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathy
[+]

An aqueous extract of the Ziziphus jujuba protects PC12 cells against high glucose-induced toxicity.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Mar ;18(3):301-6. PMID: 25945244
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Diabetic Neuropathy, Hyperglycemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Additional Keywords : Plant Extracts
[+]

Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of actions.Jan 22, 2020

Pubmed Data : Life Sci. 2020 Jan 23:117350. Epub 2020 Jan 23. PMID: 31982401
Article Published Date : Jan 22, 2020
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Diabetic Neuropathy, Diabetic Retinopathy
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

B vitamins should be considered a plausible therapy for diabetic neuropathy.Feb 08, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Pharm Ther. 2021 Feb 9. Epub 2021 Feb 9. PMID: 33565138
Article Published Date : Feb 08, 2021
Study Type : Review
Additional Links
Substances : Folic Acid , Myo-inositol, Thiamine (B-1) , Vitamin B12, Vitamin B-6
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antinoceceptive
[+]

Berberine protects against diabetic kidney disease.Nov 15, 2019

Pubmed Data : Br J Pharmacol. 2019 Nov 16. Epub 2019 Nov 16. PMID: 31734944
Article Published Date : Nov 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Chronic Kidney Disease (CKD), Diabetes: Kidney Function , Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Hypolipidemic, Renoprotective
[+]

Combination of quercetin, cinnamaldehyde and hirudin protects rat dorsal root ganglion neurons against high glucose-induced injury.Aug 31, 2017

Pubmed Data : Chin J Integr Med. 2017 Sep ;23(9):663-671. Epub 2017 Sep 2. PMID: 28861887
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde, Hirudin (from Medicinal Leaches), Quercetin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 inducer, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kiwi fruit peel extracts might contribute to the prevention of the development of diabetic neuropathy by blocking the MG-mediated intracellular glycation system.Apr 30, 2014

Pubmed Data : Pharm Biol. 2014 May ;52(5):628-36. Epub 2014 Feb 7. PMID: 24707974
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Kiwifruit
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Loganin's antioxidant effects prevent RSC96 Schwann cell pyroptosis by inhibiting ROS generation and suppressing NLRP3 inflammasome activation.Jan 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2020 08 23 ;9(9). Epub 2020 Aug 23. PMID: 32842536
Article Published Date : Jan 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Dogwood
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Methylcobalamin the activated form of vitamin B-12 is a potential pain reliever.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2013 ;2013:424651. Epub 2013 Dec 26. PMID: 24455309
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Substances : Vitamin B12: methylcobalamin , Vitamin B-12
Diseases : Diabetic Neuropathy, Low Back Pain, Neuralgia
Pharmacological Actions : Analgesics
Additional Keywords : Nerve Regeneration
[+]

Paeoniflorin effect of schwann cell-derived exosomes ameliorates dorsal root ganglion neurons apoptosis through IRE1 α pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6079305. Epub 2021 Sep 27. PMID: 34616478
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Exosomes
[+]

The role of alpha-lipoic acid supplementation in the prevention of diabetes complications.Jan 17, 2021

Pubmed Data : Curr Diabetes Rev. 2021 Jan 18. Epub 2021 Jan 18. PMID: 33461470
Article Published Date : Jan 17, 2021
Study Type : Review
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Cardiomyopathy, Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Therapeutic potential of ursolic acid in cancer and diabetic neuropathy diseases.Nov 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Nov 10 ;22(22). Epub 2021 Nov 10. PMID: 34830043
Article Published Date : Nov 09, 2021
Study Type : Review
Additional Links
Substances : Ursolic Acid
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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