Diabetic Neuropathy

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20 Substances Researched for Diabetic Neuropathy
NameACCKFocus
Alpha-Lipoic Acid211Locked
Bitter Apple110Locked
B-complex12Locked
Berberine12Locked
Curcumin12Locked
Feverfew12Locked
Fig12Locked
Grape Seed Extract12Locked
Gymnema Sylvestre12Locked
Naringenin 12Locked
Nettle12Locked
Resveratrol12Locked
Rhubarb12Locked
Saffron12Locked
St. Johns Wort12Locked
Stilbenes12Locked
Vitamin C12Locked
Vitamin E: alpha tocopherol12Locked
Jujube11Locked
Kiwifruit11Locked
2 Problem Substances Researched for Diabetic Neuropathy
NameACCKFocus
Alloxan12Locked
Rosiglitazone (trade name Avandia)12Locked
2 Therapeutic Actions Researched for Diabetic Neuropathy
NameACCKFocus
Yoga110Locked
Yogic Technique: Sudarshan kriya110Locked

View the Evidence:
44 Abstracts with Diabetic Neuropathy Research

[+]

Reduced serum levels of folate and vitamin B12 were found in Chinese patients with T2DM and diabetic peripheral neuropathy.Jan 08, 2017

Pubmed Data : Mol Cell Endocrinol. 2017 Jan 9. Epub 2017 Jan 9. PMID: 28081987
Article Published Date : Jan 08, 2017
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy, Vitamin B 12 Deficiency
[+]

Alpha lipoic has significant therapeutic value in the treatment of diabetic neuropathy. Nov 01, 2008

Pubmed Data : Bosn J Basic Med Sci. 2008 Nov;8(4):341-5. PMID: 19125705
Article Published Date : Nov 01, 2008
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy, Polyneuropathies
[+]

Application of a topical formulation of C. colocynthis fruit extract can decrease pain in patients with PDPN.Mar 19, 2015

Pubmed Data : J Diabetes. 2015 Mar 20. Epub 2015 Mar 20. PMID: 25800045
Article Published Date : Mar 19, 2015
Study Type : Human Study
Additional Links
Substances : Bitter Apple
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Aromatherapy massage was beneficial for neuropathic pain and quality of life in diabetic patients.Jun 30, 2017

Pubmed Data : J Nurs Scholarsh. 2017 Jul ;49(4):379-388. Epub 2017 Jun 12. PMID: 28605119
Article Published Date : Jun 30, 2017
Study Type : Human Study
Additional Links
Substances : Chamomile, Eucalyptus, Geranium, Lavender: Essential Oil, Rosemary: Essential Oil
Diseases : Diabetic Neuropathy
Therapeutic Actions : Aromatherapy Massage
Additional Keywords : Essential Oils
[+]

Centella asiatica triterpenes are beneficial for diabetic neuropathy.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Esper Dermatol. 2018 Jun ;20(2 Suppl 1):12-22. PMID: 31080345
Article Published Date : May 31, 2018
Study Type : Human Study
Additional Links
Substances : Gotu Kola
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

This trial points towards the beneficial effect of yogic breathing program in preventing progression of cardiac neuropathy.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Endocrinol Metab. 2014 Jul ;18(4):582-4. PMID: 25143922
Article Published Date : Jun 30, 2014
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
Therapeutic Actions : Yoga, Yogic Technique: Sudarshan kriya
Pharmacological Actions : Hypoglycemic Agents
[+]

Vitamin D supplementations improve peripheral diabetic neuropathy.Jan 31, 2019

Pubmed Data : Diabetes Metab Syndr. 2019 Jan - Feb;13(1):890-893. Epub 2018 Dec 20. PMID: 30641826
Article Published Date : Jan 31, 2019
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
[+]

Vitamin-E was found to be effective in reducing pain score in diabetic neuropathy patients.Jan 31, 2014

Pubmed Data : Pharmacol Rep. 2014 Feb ;66(1):44-8. Epub 2014 Jan 30. PMID: 24905305
Article Published Date : Jan 31, 2014
Study Type : Human Study
Additional Links
Substances : Vitamin E
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics, Antioxidants
[+]

Alpha-lipoic acid has a protective effect on peripheral neuronal cell damage generated with diabetic neuropathy.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Arch. 2018 Jun ;72(3):178-181. PMID: 30061762
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Jul-Sep;17(3):1559325819862449. Epub 2019 Jul 16. PMID: 31360147
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Analysis showed that naringenin corrected the altered sciatic changes in diabetic animals.Sep 30, 2015

Pubmed Data : Neurol Res. 2015 Oct ;37(10):924-33. Epub 2015 Jul 17. PMID: 26187552
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Diabetic Neuropathy, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy.May 31, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Jun ;392(6):697-713. Epub 2019 Feb 13. PMID: 30759263
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Combretum fragrans
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antidepressive Agents, Antinoceceptive , Antioxidants, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

B vitamins alleviate indices of neuropathic pain in diabetic rats. Jun 10, 2009

Pubmed Data : Eur J Pharmacol. 2009 Jun 10;612(1-3):41-7. Epub 2009 Apr 23. PMID: 19393643
Article Published Date : Jun 10, 2009
Study Type : Animal Study
Additional Links
Substances : B-complex
Diseases : Diabetic Neuropathy
[+]

Berberine has a beneficial effect against diabetic neuropathy by improving micropathology and increasing neuritin expression.Feb 02, 2016

Pubmed Data : Eur J Pharmacol. 2016 Feb 3. Epub 2016 Feb 3. PMID: 26849937
Article Published Date : Feb 02, 2016
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Neuropathy
Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents
[+]

Berberine is a potential therapeutic alleviating diabetes and diabetic neuropathic painMay 11, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 May 12. Epub 2019 May 12. PMID: 31079200
Article Published Date : May 11, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabeties. Mar 17, 2019

Pubmed Data : Brain Res. 2019 Mar 18. Epub 2019 Mar 18. PMID: 30898678
Article Published Date : Mar 17, 2019
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Allodynia, Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Curcumin has been demonstrated to effectively prevent or ameliorate diabetic mellitus and its complications including diabetic neuropathic pain.Aug 13, 2015

Pubmed Data : Neurosci Lett. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26282904
Article Published Date : Aug 13, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy, Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Deguelin ameliorates diabetic neuropathy by decreasing oxidative stress and plasma glucose levels.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;48(3):1164-1176. Epub 2018 Jul 25. PMID: 30045011
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Deguelin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Nrf2 activation
[+]

E. sativa might be beneficial in chronic diabetes in ameliorating the progression of diabetic neuropathy.Jul 31, 2018

Pubmed Data : Inflammopharmacology. 2018 Aug ;26(4):993-1003. Epub 2017 Nov 20. PMID: 29159712
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Arugula, Kaempferol
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antinoceceptive
Additional Keywords : Plant Extracts
[+]

Ficus racemosa exhibits protective effects by reducing complications of diabetic neuropathy with neurodegeneration (DNN).Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharmacol. 2015 Nov-Dec;47(6):610-5. PMID: 26729951
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Fig
Diseases : Diabetic Complications, Diabetic Neuropathy
Pharmacological Actions : Hypoglycemic Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(6):e39647. Epub 2012 Jun 25. PMID: 22761855
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Diabetic Neuropathy, Hyperalgesia
Pharmacological Actions : Analgesics
[+]

Grape seed extract has a therapeutic effect on oxidation-associated nerve damage in diabetic rat.s Aug 01, 2008

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):321-8. PMID: 18797155
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Diabetic Neuropathy
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Gymnema sylvestre extract application may be useful for the treatment of neuropathy in patients with chronic diabetes.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 May ;9(5):1670-1678. Epub 2015 Feb 20. PMID: 26136876
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Gymnema Sylvestre
Diseases : Diabetes Mellitus: Type 1, Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Hericium erinaceus treatment along with the antioxidant activity could be the probable way by which it had alleviated diabetic neuropathy.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:595480. Epub 2015 Apr 16. PMID: 25960754
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics, Antioxidants
Problem Substances : Alloxan
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Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.Aug 31, 2017

Pubmed Data : J Nutr Biochem. 2017 Sep ;47:41-52. Epub 2017 May 11. PMID: 28528294
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Juglans regia leaf extract exert preventive and curative effects against STZ-induced diabetic neuropathy.Oct 01, 2017

Pubmed Data : BMC Complement Altern Med. 2017 Oct 2 ;17(1):476. Epub 2017 Oct 2. PMID: 28969623
Article Published Date : Oct 01, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Moringa oleifera has neuroprotective effects in diabetic neuropathic pain model.Dec 11, 2017

Pubmed Data : Chin J Integr Med. 2017 Dec 12. Epub 2017 Dec 12. PMID: 29234979
Article Published Date : Dec 11, 2017
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Neuroprotective Agents
[+]

Nettle showed results comparable to rosiglitazone in reversing the long standing diabetes induced complications.Sep 26, 2013

Pubmed Data : Neurosci Lett. 2013 Sep 27 ;552:114-9. Epub 2013 Jul 31. PMID: 23916662
Article Published Date : Sep 26, 2013
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Diabetic Neuropathy, Memory Disorders
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Natural Substances Versus Drugs, Phytotherapy, Plant Extracts
Problem Substances : Rosiglitazone (trade name Avandia)
[+]

Neuroprotective and antinociceptive effects of rosemary extract in rats with painful diabetic neuropathy.May 11, 2018

Pubmed Data : J Physiol Sci. 2018 May 12. Epub 2018 May 12. PMID: 29754274
Article Published Date : May 11, 2018
Study Type : Animal Study
Additional Links
Substances : Rosemary
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Antinoceceptive , Neuroprotective Agents
[+]

Nigella sativa and thymoquinone could be a potential treatment against peripheral neuropathy.Dec 31, 2007

Pubmed Data : Neurochem Res. 2008 Jan ;33(1):87-96. Epub 2007 Aug 23. PMID: 17713854
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Phloretin could be a promising agent in the management of diabetic neuropathy.Apr 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 May ;101:821-832. Epub 2018 Mar 22. PMID: 29635891
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Phloretin
Diseases : Diabetic Neuropathy
[+]

Pretreatment with the extract of Rheum ribes prior to alloxination, protected the mice from acquiring diabetes and diabetic neuropathy.Mar 25, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Pharm Res. 2014 Mar 26. Epub 2014 Mar 26. PMID: 24668155
Article Published Date : Mar 25, 2014
Study Type : Animal Study
Additional Links
Substances : Rhubarb
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Hypoglycemic Agents, Prophylactic Agents
Additional Keywords : Plant Extracts, Risk Reduction
Problem Substances : Alloxan
[+]

Protective effect of diosmin against diabetic neuropathy.Dec 31, 2013

Pubmed Data : J Integr Med. 2014 Jan ;12(1):35-41. PMID: 24461593
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Plant Extracts
[+]

Resveratrol has anti-inflammatory and neuroprotective properties in experimental diabetic neuropathy.Apr 02, 2010

Pubmed Data : Biochem Biophys Res Commun. 2010 Apr 2;394(2):360-5. Epub 2010 Mar 6. PMID: 20211601
Article Published Date : Apr 02, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Diabetic Neuropathy, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Saffron extract may have a protective effect against diabetic neuropathy. Aug 27, 2009

Pubmed Data : Cell Mol Neurobiol. 2009 Aug 27. PMID: 19711182
Article Published Date : Aug 27, 2009
Study Type : Animal Study
Additional Links
Substances : Saffron
Diseases : Diabetic Neuropathy
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St. John's Wort and feverfew extracts may become new therapeutic perspectives for painful diabetic peripheral neuropathy. Dec 31, 2013

Pubmed Data : Fitoterapia. 2014 Jan ;92:23-33. Epub 2013 Oct 12. PMID: 24125916
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Feverfew, St. Johns Wort
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Tanshinone IIA could be a promising agent for painful diabetic neuropathy treatment.Oct 31, 2018

Pubmed Data : Exp Clin Endocrinol Diabetes. 2018 Nov ;126(10):632-639. Epub 2018 Jan 31. PMID: 29388177
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Neuropathy
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This study demonstrates that tanshinone IIA alleviates neuropathic pain.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kaohsiung J Med Sci. 2018 Aug ;34(8):428-437. Epub 2018 Apr 27. PMID: 30041760
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Neuropathy, Neuropathic Pain
Pharmacological Actions : Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Vitamins C and E provide synergistic neuroprotection in the jejunum in experimental diabetes.Sep 27, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pathophysiology. 2015 Sep 28. Epub 2015 Sep 28. PMID: 26433445
Article Published Date : Sep 27, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C, Vitamin E: alpha tocopherol
Diseases : Diabetes: Oxidative Stress, Diabetic Complications, Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

Alpha lipoic acid has therapeutic value in the treatment of diabetic neuropathy. Jan 01, 2009

Pubmed Data : Rev Diabet Stud. 2009;6(4):230-6. Epub 2009 Dec 30. PMID: 20043035
Article Published Date : Jan 01, 2009
Study Type : Commentary
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Diabetic Neuropathy
[+]

An aqueous extract of the Ziziphus jujuba protects PC12 cells against high glucose-induced toxicity.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Mar ;18(3):301-6. PMID: 25945244
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Diabetic Neuropathy, Hyperglycemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Additional Keywords : Plant Extracts
[+]

Combination of quercetin, cinnamaldehyde and hirudin protects rat dorsal root ganglion neurons against high glucose-induced injury.Aug 31, 2017

Pubmed Data : Chin J Integr Med. 2017 Sep ;23(9):663-671. Epub 2017 Sep 2. PMID: 28861887
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde, Hirudin (from Medicinal Leaches), Quercetin
Diseases : Diabetic Neuropathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 inducer, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kiwi fruit peel extracts might contribute to the prevention of the development of diabetic neuropathy by blocking the MG-mediated intracellular glycation system.Apr 30, 2014

Pubmed Data : Pharm Biol. 2014 May ;52(5):628-36. Epub 2014 Feb 7. PMID: 24707974
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Kiwifruit
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Methylcobalamin the activated form of vitamin B-12 is a potential pain reliever.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2013 ;2013:424651. Epub 2013 Dec 26. PMID: 24455309
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Substances : Vitamin B12: methylcobalamin , Vitamin B-12
Diseases : Diabetic Neuropathy, Low Back Pain, Neuralgia
Pharmacological Actions : Analgesics
Additional Keywords : Nerve Regeneration

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