Fibrosis

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11 Substances Researched for Fibrosis
NameACCKFocus
Barberry12Locked
Black Tea12Locked
Black Tea Theaflavins12Locked
Citrus Peel 12Locked
Naringenin 12Locked
Radish12Locked
Taurine12Locked
Bee Venom11Locked
Cannabinoids 11Locked
Resveratrol11Locked
Vitamin D11Locked
2 Problem Substances Researched for Fibrosis
NameACCKFocus
Bleomycin12Locked
Paraquat12Locked

View the Evidence:
84 Abstracts with Fibrosis Research

[+]

Use of aloe vera and turmeric paste as a supplementary medicine in oral submucosal fibrosis.Sep 30, 2019

Pubmed Data : Indian J Otolaryngol Head Neck Surg. 2019 Oct ;71(Suppl 1):883-886. Epub 2019 Jan 29. PMID: 31742088
Article Published Date : Sep 30, 2019
Study Type : Human Study
Additional Links
Substances : Aloe Vera, Turmeric
Diseases : Fibrosis
Additional Keywords : Natural Substance Synergy
[+]

Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21.Jan 01, 2018

Pubmed Data : Toxicol Appl Pharmacol. 2018 11 1 ;358:35-42. Epub 2018 Sep 7. PMID: 30201452
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Baicalein
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

Pubmed Data : Chem Biol Interact. 2019 Feb 1 ;299:131-139. Epub 2018 Dec 11. PMID: 30543783
Article Published Date : Feb 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Ferulic acid
Diseases : Fibrosis, Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Regenerative
Additional Keywords : Liver Regeneration
[+]

Photobiomodulation therapy enhances the anti-fibrotic activity of adipose-derived mesenchymal stem cells.Feb 01, 2019

Pubmed Data : Lasers Med Sci. 2019 Feb ;34(1):1-10. Epub 2018 Oct 26. PMID: 30367294
Article Published Date : Feb 01, 2019
Study Type : Human In Vitro
Additional Links
Diseases : Fibrosis
Therapeutic Actions : Photodynamic therapy
Pharmacological Actions : Anti-Fibrotic, Regenerative
[+]

The antifibrotic effect of quercetin can be enhanced by adding methyl group on functionally important position.Dec 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2019 Dec ;20:100678. Epub 2019 Aug 16. PMID: 31467991
Article Published Date : Dec 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Quercetin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Ascorbic acid attenuated the inflammatory response and fibrosis in the lungs of rats treated with lipopolysaccharide.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : SAGE Open Med. 2019 ;7:2050312119828260. Epub 2019 Feb 4. PMID: 30783524
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fibrosis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Astaxanthin provides a potential therapeutic value in pulmonary fibrosis treatment.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2015 Sep ;19(9):2215-31. Epub 2015 Jun 27. PMID: 26119034
Article Published Date : Aug 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Fibrosis
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0205535. Epub 2018 Nov 5. PMID: 30395570
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fibrosis, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation
Problem Substances : Paraquat
[+]

Berberine alleviates adipose tissue fibrosis.May 27, 2018

Pubmed Data : Biomed Pharmacother. 2018 May 28 ;105:121-129. Epub 2018 May 28. PMID: 29852389
Article Published Date : May 27, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Fibrosis, Obesity
Pharmacological Actions : Anti-Fibrotic
[+]

Berberis vulgaris fruit has beneficial effects in rat pulmonary fibrosis induced by paraquat.Jun 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jul ;81:329-36. Epub 2016 Apr 26. PMID: 27261610
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Barberry
Diseases : Fibrosis, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
Problem Substances : Paraquat
[+]

Betulinic acid derivative BA5 had a potent anti-inflammatory activity on a model of parasite-driven heart disease.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2019 ;10:1257. Epub 2019 Jun 11. PMID: 31244833
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Chagas Disease, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Caffeic acid phenethyl ester is effective in resolving colon fibrosis in chronic inflammation.Aug 23, 2018

Pubmed Data : Pathol Res Pract. 2018 Aug 24. Epub 2018 Aug 24. PMID: 30170869
Article Published Date : Aug 23, 2018
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Colitis, Fibrosis, Gastrointestinal Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma.Nov 23, 2018

Pubmed Data : Eur J Pharmacol. 2018 Nov 24. Epub 2018 Nov 24. PMID: 30481497
Article Published Date : Nov 23, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Asthma, Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis.Jan 31, 2020

Pubmed Data : Phytomedicine. 2020 Feb ;67:153160. Epub 2019 Dec 26. PMID: 31901889
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Celastrol
Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction.Sep 16, 2018

Pubmed Data : J Mol Histol. 2018 Sep 17. Epub 2018 Sep 17. PMID: 30225683
Article Published Date : Sep 16, 2018
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Fibrosis, Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Citrus maxima peel powder produced significant hepatoprotective action in carbon tetrachloride administered rats.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:598179. Epub 2015 May 28. PMID: 26106435
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Citrus Peel
Diseases : Chemically-Induced Liver Damage, Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Coenzyme Q10 inhibits the activation of pancreatic stellate cells.Nov 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 3 ;8(54):92300-92311. Epub 2017 Sep 23. PMID: 29190916
Article Published Date : Nov 02, 2017
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Components present in the Radish extract can remarkably prevent the aggravation of pulmonary fibrosis via decreasing TGF-β1 level.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2015 Sep-Oct;10(5):429-35. PMID: 26752991
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Radish
Diseases : Fibrosis
Pharmacological Actions : Chemoprotective Agents
Problem Substances : Bleomycin
[+]

CoQ10 may be a therapeutic candidate for antifibrotic methods.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:8039694. Epub 2019 Feb 7. PMID: 30881598
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice.Nov 14, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31732951
Article Published Date : Nov 14, 2019
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Fibrosis, Lung Injury: Acute, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Problem Substances : Paraquat
[+]

Effects of panax notoginseng saponin on the pathological ultrastructure and serum IL-6 and IL-8 in pulmonary fibrosis.Jun 21, 2018

Pubmed Data : J Cell Biochem. 2018 Jun 22. Epub 2018 Jun 22. PMID: 29932250
Article Published Date : Jun 21, 2018
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Fucoidan inhibits radiation-induced pneumonitis and lung fibrosis.Oct 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2018 Oct 19 ;16(10). Epub 2018 Oct 19. PMID: 30347679
Article Published Date : Oct 18, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Fibrosis, Pneumonitis, Radiotherapy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Geraniol prevents the atherogenic diet induced fibrosis in experimental hamsters.Sep 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Sep 5 ;762:102-11. Epub 2015 May 22. PMID: 26004525
Article Published Date : Sep 04, 2015
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Atherosclerosis, Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Ginger ingredients could be beneficial in alleviating diabetic prostatic complications through suppressing oxidative stress and tissue fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:6090269. Epub 2017 Aug 17. PMID: 28904557
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Diabetes: Oxidative Stress, Diabetic Complications, Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Lactobacillus rhamnosus GG reduces hepatic fibrosis in animals.Jan 04, 2017

Pubmed Data : Nutr Hosp. 2017 06 5 ;34(3):702-709. Epub 2017 Jun 5. PMID: 28627210
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG
Diseases : Fibrosis, Liver Disease
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Long-term diesel exhaust particles exposure may increase AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergy Asthma Immunol Res. 2016 May ;8(3):246-56. PMID: 26922935
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Diesel Exhaust Particle Toxicity , Fibrosis, Inflammation
[+]

Low-level laser therapy accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine.Feb 28, 2017

Pubmed Data : J Photochem Photobiol B. 2017 Mar ;168:30-39. Epub 2017 Jan 26. PMID: 28161653
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Diseases : Fibrosis, Surgery: Anesthesiology
Therapeutic Actions : Laser Treatment: Low-Level
Additional Keywords : Muscle Regeneration
[+]

Lung injury induced by bisphenol A is ameliorated by selenium supplementation.Feb 11, 2017

Pubmed Data : Pathophysiology. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28285737
Article Published Date : Feb 11, 2017
Study Type : Animal Study
Additional Links
Substances : Selenium
Diseases : Bisphenol Toxicity, Fibrosis, Lung Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Bisphenol Toxicity, Fibrosis, Lung Damage, Selenium
Problem Substances : Bisphenol A
[+]

Luteolin ameliorates diet-induced obesity and its comorbidities.Oct 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Oct 3 ;10(10). Epub 2018 Oct 3. PMID: 30282902
Article Published Date : Oct 02, 2018
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Fibrosis, Hepatic Steatosis, Insulin Resistance, Obesity
Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents
Additional Keywords : Anti-Obesity Agents
[+]

Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro.Nov 23, 2010

Pubmed Data : J Agric Food Chem. 2010 Nov 24 ;58(22):11653-61. Epub 2010 Oct 19. PMID: 20958047
Article Published Date : Nov 23, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model.May 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 May 31 ;9(1):8134. Epub 2019 May 31. PMID: 31148586
Article Published Date : May 30, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Cystitis, Fibrosis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic
[+]

Naringenin exerts a pharmacological effect against the progression of cardiac hypertrophy induced by pressure overload. Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Dec ;10(6):2206-2212. Epub 2015 Oct 19. PMID: 26668617
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Naringenin treatment suppressed the inflammatory response and pulmonary fibrosis by inhibition of autophagy after Mycoplasma pneumoniae infection.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2018 ;2018:8753894. Epub 2018 Apr 4. PMID: 29849498
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Fibrosis, Mycoplasma Infections, Pneumonia
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Nigella sativa oil treatment attenuated the effects of bleomycin induced pulmonary fibrosis.Apr 12, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr 13 ;90:626-637. Epub 2017 Apr 13. PMID: 28412654
Article Published Date : Apr 12, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Nigella sativa treatment might be beneficial in lung injury and have potential clinical use.Dec 31, 2008

Pubmed Data : Acta Histochem. 2009 ;111(5):393-403. Epub 2009 May 9. PMID: 19428057
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Lung Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.May 31, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jun ;417(1-2):87-96. Epub 2016 May 10. PMID: 27160937
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Cardiomyopathy, Diabetes Mellitus: Type 1, Diabetic Complications, Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
Additional Keywords : Fibronectin
[+]

Oleanolic acid acetate may mitigate the inflammatory response and development of pulmonary fibrosis in the lungs.Mar 01, 2018

Pubmed Data : Respir Physiol Neurobiol. 2018 Mar 2 ;252-253:1-9. Epub 2018 Mar 2. PMID: 29505886
Article Published Date : Mar 01, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Fibrosis, Lung Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway.Jan 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 01 18 ;7:40183. Epub 2017 Jan 18. PMID: 28098144
Article Published Date : Jan 17, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Chronic Kidney Disease (CKD), Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model.Jul 31, 2019

Pubmed Data : J Cell Physiol. 2019 Aug ;234(8):14351-14363. Epub 2019 Feb 4. PMID: 30714138
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Palmitoylethanolamide reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis.Aug 31, 2016

Pubmed Data : Pharmacol Res. 2016 Sep ;111:405-412. Epub 2016 Jul 8. PMID: 27402190
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Panax notoginseng saponins is capable of improving peritoneal function in subjects with peritoneal dialysis.Dec 31, 2014

Pubmed Data : Ren Fail. 2015 ;37(9):1507-13. Epub 2015 Sep 15. PMID: 26371362
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Fibrosis
Additional Keywords : Plant Extracts
[+]

Parthenolide alleviates peritoneal fibrosis.Dec 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2019 Dec 12 ;78:106064. Epub 2019 Dec 12. PMID: 31838448
Article Published Date : Dec 11, 2019
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Puerarin has the therapeutic effect on the pulmonary hypertension and accompanying pulmonary fibrosis.May 31, 2018

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Jun ;43(12):2618-2623. PMID: 29950085
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Fibrosis, Hypertension: Pulmonary, Hypoxia
Pharmacological Actions : Anti-Fibrotic
[+]

Regular boysenberry consumption has the potential to moderate chronic lung remodelling and fibrosis in asthma and other chronic pulmonary diseases.Aug 31, 2016

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1 ;311(3):L628-38. Epub 2016 Jul 1. PMID: 27371734
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Berries: All
Diseases : Asthma, Fibrosis, Lung Diseases
Pharmacological Actions : Anti-Fibrotic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Resveratrol alleviates chronic ambient particulate matter-induced lung inflammation and fibrosis.Oct 29, 2019

Pubmed Data : Ecotoxicol Environ Saf. 2019 Oct 30 ;182:109425. Epub 2019 Jul 8. PMID: 31295660
Article Published Date : Oct 29, 2019
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Air Pollution Linked Toxicity, Fibrosis, Lung Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jan ;121:109586. Epub 2019 Nov 6. PMID: 31706104
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Taurine was found to reduce epidural fibrosis in rat models.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;38(6):2261-71. Epub 2016 May 19. PMID: 27188306
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Taurine
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Theaflavin enriched black tea extracts exhibited hepatoprotective effects on experimental fibrosis.Jun 09, 2015

Pubmed Data : Food Funct. 2015 Jun 10 ;6(6):1832-40. PMID: 25927469
Article Published Date : Jun 09, 2015
Study Type : Animal Study
Additional Links
Substances : Black Tea, Black Tea Theaflavins
Diseases : Fibrosis, Liver Cancer: Prevention, Liver Damage
Pharmacological Actions : Hepatoprotective
Additional Keywords : Risk Reduction
[+]

These data support the potential use of NAC as an adjunctive therapy in human dystrophinopathies.Nov 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771272
Article Published Date : Nov 23, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Duchenne's Muscular Dystrophy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

These findings suggest that piperine treatment ameliorates pancreatic fibrosis.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Oct ;20(4):3709-3718. Epub 2019 Sep 2. PMID: 31485676
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Fibrosis, Pancreatitis
Pharmacological Actions : Pancreato Protective Agents
[+]

Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;49(4):1551-1563. Epub 2018 Sep 13. PMID: 30212825
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Fibrosis, Renal Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice.Sep 01, 2015

Pubmed Data : Mol Cell Biochem. 2015 Sep ;407(1-2):263-79. Epub 2015 Jun 16. PMID: 26077659
Article Published Date : Sep 01, 2015
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Fibrosis, Insulin Resistance, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Regenerative
Additional Keywords : Heart Regeneration
Problem Substances : Fructose
[+]

Acetyl‐11‐keto‐β‐boswellic acid ameliorates renal interstitial fibrosis.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2018 Oct ;22(10):4997-5007. Epub 2018 Jul 28. PMID: 30054990
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Ophthalmol. 2018 ;11(2):189-195. Epub 2018 Feb 18. PMID: 29487805
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Fibrosis, Pterygium
Pharmacological Actions : Anti-Fibrotic
[+]

Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression.Jun 28, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun 29 ;106:373-380. Epub 2018 Jun 29. PMID: 29966983
Article Published Date : Jun 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Arctigenin may act as a suitable adjunct therapy for oral submucous fibrosis.Mar 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Mar 16 ;20(6). Epub 2019 Mar 16. PMID: 30884781
Article Published Date : Mar 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astaxanthin could relieve the symptoms and halt the progression of pulmonary fibrosis.May 31, 2013

Pubmed Data : Food Chem Toxicol. 2013 Jun ;56:450-8. Epub 2013 Mar 14. PMID: 23500768
Article Published Date : May 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Biological activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in antiaging and antiaging-related disease treatments.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:4973239. Epub 2016 Jun 20. PMID: 27413420
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Aging, Alzheimer's Disease, Atherosclerosis, Brain Inflammation , Cerebral Ischemia, Fibrosis, Memory Disorders, Parkinson's Disease
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Cardiovascular Agents, Hypoglycemic Agents, Neuroprotective Agents
Additional Keywords : Phytotherapy
[+]

Butyrate or phenylbutyrate and could be novel types of prophylactic and therapeutic treatments for pterygium.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Ophthalmol. 2017 ;10(9):1337-1343. Epub 2017 Sep 18. PMID: 28944189
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Fibrosis, Pterygium
Pharmacological Actions : Anti-Fibrotic
[+]

Carnosic acid might be a prospective therapeutic drug for liver fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:976. Epub 2018 Jan 19. PMID: 29403377
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Carthamus tinctorius L may potentially serve as a cardio-protective agent against LPS- induced cardiac fibrosis.Feb 28, 2017

Pubmed Data : Environ Toxicol. 2017 Mar ;32(3):754-763. Epub 2016 Apr 20. PMID: 27098997
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Fibrosis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Plant Extracts
[+]

Centella asiatica and asiatic acid can be used as antifibrotic agents.Apr 30, 2017

Pubmed Data : J Investig Clin Dent. 2017 May ;8(2). Epub 2016 Feb 3. PMID: 26840561
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gotu Kola
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Plant Extracts
[+]

Coenzyme Q10 supplementation in fibrosis and aging.Dec 31, 2018

Pubmed Data : Adv Exp Med Biol. 2019 ;1178:103-112. PMID: 31493224
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Coenzyme Q10
Diseases : Cardiovascular Diseases, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Curcumin is able to prevent epithelial-to-mesenchymal transition progress in intestinal fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7876064. Epub 2017 Jan 22. PMID: 28203261
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Inhibitory effects of astragaloside IV on silica-induced pulmonary fibrosis.Sep 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Sep 2 ;119:109387. Epub 2019 Sep 2. PMID: 31487583
Article Published Date : Sep 01, 2019
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Isoliquiritigenin may be a potential therapeutic agent for the prevention and treatment of mesangial fibrosis and glomerulosclerosis.Mar 09, 2010

Pubmed Data : J Agric Food Chem. 2010 Mar 10 ;58(5):3205-12. PMID: 20146476
Article Published Date : Mar 09, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Diabetic Nephropathy, Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Nigella sativa and thymoquinone have been shown to promote wound healing, attenuate tissue inflammation, and prevent organ fibrosis via regulation of the epithelial to mesenchymal transition process.Oct 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2019 Oct 30 ;19(1):290. Epub 2019 Oct 30. PMID: 31666058
Article Published Date : Oct 30, 2019
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Bodily Tissue Regeneration, Phytotherapy, Plant Extracts
[+]

NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter.Nov 14, 2018

Pubmed Data : Ecotoxicol Environ Saf. 2018 Nov 15 ;163:612-619. Epub 2018 Aug 6. PMID: 30092543
Article Published Date : Nov 14, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Air Pollution Linked Toxicity, Fibrosis, Lung Inflammation
Additional Keywords : Risk Factors
[+]

NS extract is a therapeutic agent to treat the UUO-induced kidney damage comparable with the well-known RAS inhibitors captopril and losartan.Aug 01, 2018

Pubmed Data : Phytother Res. 2018 Aug 2. Epub 2018 Aug 2. PMID: 30070029
Article Published Date : Aug 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Additional Keywords : Natural Substances Versus Drugs
[+]

Oleanolic acid may be a promising therapeutic agent in the treatment of renal fibrosis.Jul 03, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jul 4 ;18(1):205. Epub 2018 Jul 4. PMID: 29973206
Article Published Date : Jul 03, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Fibrosis, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Photobotanical combinations may usher in new therapeutics or phototherapy adjuvants for the treatment of dermatologic diseases.Dec 31, 2016

Pubmed Data : Dermatol Surg. 2017 Jan ;43(1):81-86. PMID: 28027199
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Fibrosis, Skin Diseases
Therapeutic Actions : Integrative Medicine, Light-Emitting Diodes (LEDs) Therapy
[+]

Protective effects of Moringa oleifera on hepatitis B virus genotypes C and H transiently transfected Huh7 cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Immunol Res. 2017 ;2017:6063850. Epub 2017 Oct 26. PMID: 29214184
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera
Diseases : Fibrosis, Hepatitis B
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Resveratrol inhibits ROS-promoted activation and glycolysis of pancreatic stellate cells via suppression of miR-21.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1346958. Epub 2018 Apr 26. PMID: 29854071
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Fibrosis, Pancreatitis
Pharmacological Actions : MicroRNA modulator, Pancreato Protective Agents
[+]

Resveratrol is a potential therapeutic agent against diabetic renal fibrosis via regulation of AMPK/NOX4/ROS signaling.Aug 03, 2016

Pubmed Data : Food Funct. 2016 Aug 4. Epub 2016 Aug 4. PMID: 27489133
Article Published Date : Aug 03, 2016
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Diabetic Nephropathy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis.Apr 10, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 Apr 11. Epub 2018 Apr 11. PMID: 29654764
Article Published Date : Apr 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(9):e0184368. Epub 2017 Sep 6. PMID: 28877257
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemaric Acid
Diseases : Fibrosis
Pharmacological Actions : Apoptotic, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Several cannabinoids may be considered candidates for development as anti-inflammatory and antifibrotic agents.Jul 18, 2016

Pubmed Data : FASEB J. 2016 Jul 19. Epub 2016 Jul 19. PMID: 27435265
Article Published Date : Jul 18, 2016
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Fibrosis, Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition.Apr 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pharmacol Toxicol. 2018 Apr 2 ;19(1):13. Epub 2018 Apr 2. PMID: 29609658
Article Published Date : Apr 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Tanshinone IIA activates nuclear factor-erythroid 2-related factor 2 to restrain pulmonary fibrosis.May 19, 2019

Pubmed Data : Antioxid Redox Signal. 2019 May 20 ;30(15):1831-1848. Epub 2018 Sep 22. PMID: 30105924
Article Published Date : May 19, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

The present study reviews current understanding of the mechanisms of the anti-inflammatory properties of bee venom.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2015 ;7(11):4758-72. Epub 2015 Nov 16. PMID: 26580653
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Bee Venom
Diseases : Atherosclerosis, Fibrosis, Inflammation, Liver Fibrosis, Skin Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

This review highlights the effects of vitamin D on CCN gene expression in the setting of two common pathologic conditions, fibrosis and cancer.Jul 22, 2016

Pubmed Data : Cell Signal. 2016 Jul 23. Epub 2016 Jul 23. PMID: 27460560
Article Published Date : Jul 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Cancers: All, Fibrosis
Additional Keywords : Gene Expression Regulation
[+]

Total flavone of Abelmoschus manihot is expected to advance as a new therapy to treat Crohn's disease intestinal fibrosis.Aug 13, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2018 Aug 14 ;24(30):3414-3425. PMID: 30122880
Article Published Date : Aug 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Okra
Diseases : Crohn's Disease, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts

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