Fibrosis

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11 Substances Researched for Fibrosis
NameACCKFocus
Barberry12Locked
Black Tea12Locked
Black Tea Theaflavins12Locked
Citrus Peel 12Locked
Naringenin 12Locked
Radish12Locked
Taurine12Locked
Bee Venom11Locked
Cannabinoids 11Locked
Resveratrol11Locked
Vitamin D11Locked
2 Problem Substances Researched for Fibrosis
NameACCKFocus
Bleomycin12Locked
Paraquat12Locked

View the Evidence:
73 Abstracts with Fibrosis Research

[+]

Use of aloe vera and turmeric paste as a supplementary medicine in oral submucosal fibrosis.Sep 30, 2019

Pubmed Data : Indian J Otolaryngol Head Neck Surg. 2019 Oct ;71(Suppl 1):883-886. Epub 2019 Jan 29. PMID: 31742088
Article Published Date : Sep 30, 2019
Study Type : Human Study
Additional Links
Substances : Aloe Vera, Turmeric
Diseases : Fibrosis
Additional Keywords : Natural Substance Synergy
[+]

Ascorbic acid attenuated the inflammatory response and fibrosis in the lungs of rats treated with lipopolysaccharide.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : SAGE Open Med. 2019 ;7:2050312119828260. Epub 2019 Feb 4. PMID: 30783524
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fibrosis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Astaxanthin provides a potential therapeutic value in pulmonary fibrosis treatment.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2015 Sep ;19(9):2215-31. Epub 2015 Jun 27. PMID: 26119034
Article Published Date : Aug 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Fibrosis
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0205535. Epub 2018 Nov 5. PMID: 30395570
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fibrosis, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation
Problem Substances : Paraquat
[+]

Berberine alleviates adipose tissue fibrosis.May 27, 2018

Pubmed Data : Biomed Pharmacother. 2018 May 28 ;105:121-129. Epub 2018 May 28. PMID: 29852389
Article Published Date : May 27, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Fibrosis, Obesity
Pharmacological Actions : Anti-Fibrotic
[+]

Berberis vulgaris fruit has beneficial effects in rat pulmonary fibrosis induced by paraquat.Jun 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jul ;81:329-36. Epub 2016 Apr 26. PMID: 27261610
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Barberry
Diseases : Fibrosis, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
Problem Substances : Paraquat
[+]

Betulinic acid derivative BA5 had a potent anti-inflammatory activity on a model of parasite-driven heart disease.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2019 ;10:1257. Epub 2019 Jun 11. PMID: 31244833
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Chagas Disease, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Caffeic acid phenethyl ester is effective in resolving colon fibrosis in chronic inflammation.Aug 23, 2018

Pubmed Data : Pathol Res Pract. 2018 Aug 24. Epub 2018 Aug 24. PMID: 30170869
Article Published Date : Aug 23, 2018
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Colitis, Fibrosis, Gastrointestinal Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma.Nov 23, 2018

Pubmed Data : Eur J Pharmacol. 2018 Nov 24. Epub 2018 Nov 24. PMID: 30481497
Article Published Date : Nov 23, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Asthma, Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction.Sep 16, 2018

Pubmed Data : J Mol Histol. 2018 Sep 17. Epub 2018 Sep 17. PMID: 30225683
Article Published Date : Sep 16, 2018
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Fibrosis, Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Citrus maxima peel powder produced significant hepatoprotective action in carbon tetrachloride administered rats.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:598179. Epub 2015 May 28. PMID: 26106435
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Citrus Peel
Diseases : Chemically-Induced Liver Damage, Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Coenzyme Q10 inhibits the activation of pancreatic stellate cells.Nov 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 3 ;8(54):92300-92311. Epub 2017 Sep 23. PMID: 29190916
Article Published Date : Nov 02, 2017
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Components present in the Radish extract can remarkably prevent the aggravation of pulmonary fibrosis via decreasing TGF-β1 level.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2015 Sep-Oct;10(5):429-35. PMID: 26752991
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Radish
Diseases : Fibrosis
Pharmacological Actions : Chemoprotective Agents
Problem Substances : Bleomycin
[+]

CoQ10 may be a therapeutic candidate for antifibrotic methods.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:8039694. Epub 2019 Feb 7. PMID: 30881598
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice.Nov 14, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31732951
Article Published Date : Nov 14, 2019
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Fibrosis, Lung Injury: Acute, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Problem Substances : Paraquat
[+]

Effects of panax notoginseng saponin on the pathological ultrastructure and serum IL-6 and IL-8 in pulmonary fibrosis.Jun 21, 2018

Pubmed Data : J Cell Biochem. 2018 Jun 22. Epub 2018 Jun 22. PMID: 29932250
Article Published Date : Jun 21, 2018
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Fucoidan inhibits radiation-induced pneumonitis and lung fibrosis.Oct 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2018 Oct 19 ;16(10). Epub 2018 Oct 19. PMID: 30347679
Article Published Date : Oct 18, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Fibrosis, Pneumonitis, Radiotherapy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Geraniol prevents the atherogenic diet induced fibrosis in experimental hamsters.Sep 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Sep 5 ;762:102-11. Epub 2015 May 22. PMID: 26004525
Article Published Date : Sep 04, 2015
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Atherosclerosis, Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Ginger ingredients could be beneficial in alleviating diabetic prostatic complications through suppressing oxidative stress and tissue fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:6090269. Epub 2017 Aug 17. PMID: 28904557
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Diabetes: Oxidative Stress, Diabetic Complications, Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Lactobacillus rhamnosus GG reduces hepatic fibrosis in animals.Jan 04, 2017

Pubmed Data : Nutr Hosp. 2017 06 5 ;34(3):702-709. Epub 2017 Jun 5. PMID: 28627210
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG
Diseases : Fibrosis, Liver Disease
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Long-term diesel exhaust particles exposure may increase AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergy Asthma Immunol Res. 2016 May ;8(3):246-56. PMID: 26922935
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Diesel Exhaust Particle Toxicity , Fibrosis, Inflammation
[+]

Low-level laser therapy accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine.Feb 28, 2017

Pubmed Data : J Photochem Photobiol B. 2017 Mar ;168:30-39. Epub 2017 Jan 26. PMID: 28161653
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Diseases : Fibrosis, Surgery: Anesthesiology
Therapeutic Actions : Laser Treatment: Low-Level
Additional Keywords : Muscle Regeneration
[+]

Lung injury induced by bisphenol A is ameliorated by selenium supplementation.Feb 11, 2017

Pubmed Data : Pathophysiology. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28285737
Article Published Date : Feb 11, 2017
Study Type : Animal Study
Additional Links
Substances : Selenium
Diseases : Bisphenol Toxicity, Fibrosis, Lung Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Bisphenol Toxicity, Fibrosis, Lung Damage, Selenium
Problem Substances : Bisphenol A
[+]

Luteolin ameliorates diet-induced obesity and its comorbidities.Oct 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Oct 3 ;10(10). Epub 2018 Oct 3. PMID: 30282902
Article Published Date : Oct 02, 2018
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Fibrosis, Hepatic Steatosis, Insulin Resistance, Obesity
Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents
Additional Keywords : Anti-Obesity Agents
[+]

Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro.Nov 23, 2010

Pubmed Data : J Agric Food Chem. 2010 Nov 24 ;58(22):11653-61. Epub 2010 Oct 19. PMID: 20958047
Article Published Date : Nov 23, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model.May 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 May 31 ;9(1):8134. Epub 2019 May 31. PMID: 31148586
Article Published Date : May 30, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Cystitis, Fibrosis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic
[+]

Naringenin exerts a pharmacological effect against the progression of cardiac hypertrophy induced by pressure overload. Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Dec ;10(6):2206-2212. Epub 2015 Oct 19. PMID: 26668617
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Naringenin treatment suppressed the inflammatory response and pulmonary fibrosis by inhibition of autophagy after Mycoplasma pneumoniae infection.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2018 ;2018:8753894. Epub 2018 Apr 4. PMID: 29849498
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Fibrosis, Mycoplasma Infections, Pneumonia
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Nigella sativa oil treatment attenuated the effects of bleomycin induced pulmonary fibrosis.Apr 12, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr 13 ;90:626-637. Epub 2017 Apr 13. PMID: 28412654
Article Published Date : Apr 12, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Nigella sativa treatment might be beneficial in lung injury and have potential clinical use.Dec 31, 2008

Pubmed Data : Acta Histochem. 2009 ;111(5):393-403. Epub 2009 May 9. PMID: 19428057
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Lung Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.May 31, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jun ;417(1-2):87-96. Epub 2016 May 10. PMID: 27160937
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Cardiomyopathy, Diabetes Mellitus: Type 1, Diabetic Complications, Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
Additional Keywords : Fibronectin
[+]

Oleanolic acid acetate may mitigate the inflammatory response and development of pulmonary fibrosis in the lungs.Mar 01, 2018

Pubmed Data : Respir Physiol Neurobiol. 2018 Mar 2 ;252-253:1-9. Epub 2018 Mar 2. PMID: 29505886
Article Published Date : Mar 01, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Fibrosis, Lung Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway.Jan 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 01 18 ;7:40183. Epub 2017 Jan 18. PMID: 28098144
Article Published Date : Jan 17, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Chronic Kidney Disease (CKD), Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model.Jul 31, 2019

Pubmed Data : J Cell Physiol. 2019 Aug ;234(8):14351-14363. Epub 2019 Feb 4. PMID: 30714138
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Palmitoylethanolamide reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis.Aug 31, 2016

Pubmed Data : Pharmacol Res. 2016 Sep ;111:405-412. Epub 2016 Jul 8. PMID: 27402190
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Panax notoginseng saponins is capable of improving peritoneal function in subjects with peritoneal dialysis.Dec 31, 2014

Pubmed Data : Ren Fail. 2015 ;37(9):1507-13. Epub 2015 Sep 15. PMID: 26371362
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Fibrosis
Additional Keywords : Plant Extracts
[+]

Parthenolide alleviates peritoneal fibrosis.Dec 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2019 Dec 12 ;78:106064. Epub 2019 Dec 12. PMID: 31838448
Article Published Date : Dec 11, 2019
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Puerarin has the therapeutic effect on the pulmonary hypertension and accompanying pulmonary fibrosis.May 31, 2018

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Jun ;43(12):2618-2623. PMID: 29950085
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Fibrosis, Hypertension: Pulmonary, Hypoxia
Pharmacological Actions : Anti-Fibrotic
[+]

Regular boysenberry consumption has the potential to moderate chronic lung remodelling and fibrosis in asthma and other chronic pulmonary diseases.Aug 31, 2016

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1 ;311(3):L628-38. Epub 2016 Jul 1. PMID: 27371734
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Berries: All
Diseases : Asthma, Fibrosis, Lung Diseases
Pharmacological Actions : Anti-Fibrotic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jan ;121:109586. Epub 2019 Nov 6. PMID: 31706104
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Taurine was found to reduce epidural fibrosis in rat models.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;38(6):2261-71. Epub 2016 May 19. PMID: 27188306
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Taurine
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Theaflavin enriched black tea extracts exhibited hepatoprotective effects on experimental fibrosis.Jun 09, 2015

Pubmed Data : Food Funct. 2015 Jun 10 ;6(6):1832-40. PMID: 25927469
Article Published Date : Jun 09, 2015
Study Type : Animal Study
Additional Links
Substances : Black Tea, Black Tea Theaflavins
Diseases : Fibrosis, Liver Cancer: Prevention, Liver Damage
Pharmacological Actions : Hepatoprotective
Additional Keywords : Risk Reduction
[+]

These data support the potential use of NAC as an adjunctive therapy in human dystrophinopathies.Nov 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771272
Article Published Date : Nov 23, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Duchenne's Muscular Dystrophy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

These findings suggest that piperine treatment ameliorates pancreatic fibrosis.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Oct ;20(4):3709-3718. Epub 2019 Sep 2. PMID: 31485676
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Fibrosis, Pancreatitis
Pharmacological Actions : Pancreato Protective Agents
[+]

Acetyl‐11‐keto‐β‐boswellic acid ameliorates renal interstitial fibrosis.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2018 Oct ;22(10):4997-5007. Epub 2018 Jul 28. PMID: 30054990
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Ophthalmol. 2018 ;11(2):189-195. Epub 2018 Feb 18. PMID: 29487805
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Fibrosis, Pterygium
Pharmacological Actions : Anti-Fibrotic
[+]

Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression.Jun 28, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun 29 ;106:373-380. Epub 2018 Jun 29. PMID: 29966983
Article Published Date : Jun 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Arctigenin may act as a suitable adjunct therapy for oral submucous fibrosis.Mar 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Mar 16 ;20(6). Epub 2019 Mar 16. PMID: 30884781
Article Published Date : Mar 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astaxanthin could relieve the symptoms and halt the progression of pulmonary fibrosis.May 31, 2013

Pubmed Data : Food Chem Toxicol. 2013 Jun ;56:450-8. Epub 2013 Mar 14. PMID: 23500768
Article Published Date : May 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Biological activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in antiaging and antiaging-related disease treatments.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:4973239. Epub 2016 Jun 20. PMID: 27413420
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Aging, Alzheimer's Disease, Atherosclerosis, Brain Inflammation , Cerebral Ischemia, Fibrosis, Memory Disorders, Parkinson's Disease
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Cardiovascular Agents, Hypoglycemic Agents, Neuroprotective Agents
Additional Keywords : Phytotherapy
[+]

Butyrate or phenylbutyrate and could be novel types of prophylactic and therapeutic treatments for pterygium.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Ophthalmol. 2017 ;10(9):1337-1343. Epub 2017 Sep 18. PMID: 28944189
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Fibrosis, Pterygium
Pharmacological Actions : Anti-Fibrotic
[+]

Carnosic acid might be a prospective therapeutic drug for liver fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:976. Epub 2018 Jan 19. PMID: 29403377
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Carthamus tinctorius L may potentially serve as a cardio-protective agent against LPS- induced cardiac fibrosis.Feb 28, 2017

Pubmed Data : Environ Toxicol. 2017 Mar ;32(3):754-763. Epub 2016 Apr 20. PMID: 27098997
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Fibrosis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Plant Extracts
[+]

Centella asiatica and asiatic acid can be used as antifibrotic agents.Apr 30, 2017

Pubmed Data : J Investig Clin Dent. 2017 May ;8(2). Epub 2016 Feb 3. PMID: 26840561
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gotu Kola
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Plant Extracts
[+]

Coenzyme Q10 supplementation in fibrosis and aging.Dec 31, 2018

Pubmed Data : Adv Exp Med Biol. 2019 ;1178:103-112. PMID: 31493224
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Coenzyme Q10
Diseases : Cardiovascular Diseases, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Curcumin is able to prevent epithelial-to-mesenchymal transition progress in intestinal fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7876064. Epub 2017 Jan 22. PMID: 28203261
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Inhibitory effects of astragaloside IV on silica-induced pulmonary fibrosis.Sep 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Sep 2 ;119:109387. Epub 2019 Sep 2. PMID: 31487583
Article Published Date : Sep 01, 2019
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Isoliquiritigenin may be a potential therapeutic agent for the prevention and treatment of mesangial fibrosis and glomerulosclerosis.Mar 09, 2010

Pubmed Data : J Agric Food Chem. 2010 Mar 10 ;58(5):3205-12. PMID: 20146476
Article Published Date : Mar 09, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Diabetic Nephropathy, Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

NS extract is a therapeutic agent to treat the UUO-induced kidney damage comparable with the well-known RAS inhibitors captopril and losartan.Aug 01, 2018

Pubmed Data : Phytother Res. 2018 Aug 2. Epub 2018 Aug 2. PMID: 30070029
Article Published Date : Aug 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Additional Keywords : Natural Substances Versus Drugs
[+]

Oleanolic acid may be a promising therapeutic agent in the treatment of renal fibrosis.Jul 03, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jul 4 ;18(1):205. Epub 2018 Jul 4. PMID: 29973206
Article Published Date : Jul 03, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Fibrosis, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Photobotanical combinations may usher in new therapeutics or phototherapy adjuvants for the treatment of dermatologic diseases.Dec 31, 2016

Pubmed Data : Dermatol Surg. 2017 Jan ;43(1):81-86. PMID: 28027199
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Fibrosis, Skin Diseases
Therapeutic Actions : Integrative Medicine, Light-Emitting Diodes (LEDs) Therapy
[+]

Protective effects of Moringa oleifera on hepatitis B virus genotypes C and H transiently transfected Huh7 cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Immunol Res. 2017 ;2017:6063850. Epub 2017 Oct 26. PMID: 29214184
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera
Diseases : Fibrosis, Hepatitis B
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Resveratrol inhibits ROS-promoted activation and glycolysis of pancreatic stellate cells via suppression of miR-21.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1346958. Epub 2018 Apr 26. PMID: 29854071
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Fibrosis, Pancreatitis
Pharmacological Actions : MicroRNA modulator, Pancreato Protective Agents
[+]

Resveratrol is a potential therapeutic agent against diabetic renal fibrosis via regulation of AMPK/NOX4/ROS signaling.Aug 03, 2016

Pubmed Data : Food Funct. 2016 Aug 4. Epub 2016 Aug 4. PMID: 27489133
Article Published Date : Aug 03, 2016
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Diabetic Nephropathy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis.Apr 10, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 Apr 11. Epub 2018 Apr 11. PMID: 29654764
Article Published Date : Apr 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(9):e0184368. Epub 2017 Sep 6. PMID: 28877257
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemaric Acid
Diseases : Fibrosis
Pharmacological Actions : Apoptotic, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Several cannabinoids may be considered candidates for development as anti-inflammatory and antifibrotic agents.Jul 18, 2016

Pubmed Data : FASEB J. 2016 Jul 19. Epub 2016 Jul 19. PMID: 27435265
Article Published Date : Jul 18, 2016
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Fibrosis, Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition.Apr 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pharmacol Toxicol. 2018 Apr 2 ;19(1):13. Epub 2018 Apr 2. PMID: 29609658
Article Published Date : Apr 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Tanshinone IIA activates nuclear factor-erythroid 2-related factor 2 to restrain pulmonary fibrosis.May 19, 2019

Pubmed Data : Antioxid Redox Signal. 2019 May 20 ;30(15):1831-1848. Epub 2018 Sep 22. PMID: 30105924
Article Published Date : May 19, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

The present study reviews current understanding of the mechanisms of the anti-inflammatory properties of bee venom.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2015 ;7(11):4758-72. Epub 2015 Nov 16. PMID: 26580653
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Bee Venom
Diseases : Atherosclerosis, Fibrosis, Inflammation, Liver Fibrosis, Skin Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

This review highlights the effects of vitamin D on CCN gene expression in the setting of two common pathologic conditions, fibrosis and cancer.Jul 22, 2016

Pubmed Data : Cell Signal. 2016 Jul 23. Epub 2016 Jul 23. PMID: 27460560
Article Published Date : Jul 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Cancers: All, Fibrosis
Additional Keywords : Gene Expression Regulation
[+]

Total flavone of Abelmoschus manihot is expected to advance as a new therapy to treat Crohn's disease intestinal fibrosis.Aug 13, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2018 Aug 14 ;24(30):3414-3425. PMID: 30122880
Article Published Date : Aug 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Okra
Diseases : Crohn's Disease, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts

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