Insomnia

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25 Substances Researched for Insomnia
NameACCKFocus
Valerian854Locked
Lavender550Locked
Cannabis220Locked
Tart Cherry220Locked
Kava Kava212Locked
Melatonin212Locked
Cannabinoids 110Locked
Gourd110Locked
Homeopathic Medicine: All110Locked
Hops110Locked
Magnesium110Locked
Marijuana110Locked
Pumpkin Seed Oil/Meal110Locked
Tryptophan110Locked
Cannabidiol 13Locked
Vitamin C13Locked
Ziziphus spinosa23Locked
Aloe Vera12Locked
Carotenoids12Locked
Crocetin12Locked
Crocin12Locked
Curcumin12Locked
Saffron12Locked
Schisandra12Locked
Magnolia11Locked
4 Problem Substances Researched for Insomnia
NameACCKFocus
Chemotherapy120Locked
Statin Drugs120Locked
Cell Phone Exposure212Locked
Lovastatin110Locked
14 Therapeutic Actions Researched for Insomnia
NameACCKFocus
Acupuncture651Locked
Aromatherapy 440Locked
Acupressure330Locked
Massage/Therapeutic Touch330Locked
Tai Chi322Locked
Cognitive Behavioural Approaches220Locked
Electroacupuncture220Locked
Moxibustion220Locked
Music220Locked
Napping212Locked
Grounding: Contact with the Earth110Locked
Homeopathic Treatment110Locked
Hormone Replacement Therapy110Locked
Laughter/Humor110Locked
2 Problematic Actions Researched for Insomnia
NameACCKFocus
Chemotherapy120Locked
Electromagnetic Fields12Locked

View the Evidence:
86 Abstracts with Insomnia Research

[+]

Insomnia is a possible statin-associated psychiatric adverse effect.Jan 01, 2008

Pubmed Data : Drug Saf. 2008;31(12):1115-23. PMID: 19026028
Article Published Date : Jan 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Insomnia
Problem Substances : Statin Drugs
[+]

There are high rates of behavioral symptoms in breast cancer survivors, particularly those treated with chemotherapyAug 08, 2011

Pubmed Data : J Clin Oncol. 2011 Aug 8. Epub 2011 Aug 8. PMID: 21825266
Article Published Date : Aug 08, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Chemotherapy-Induced Toxicity, Depression, Fatigue, Inflammation, Insomnia
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Chemotherapy
Adverse Pharmacological Actions : Inflammatory, Tumor necrosis factorα (TNFα) up-regulation
[+]

"Acupuncture improves sleep in postmenopause in a randomized, double-blind, placebo-controlled study."Sep 02, 2012

Pubmed Data : Climacteric. 2012 Sep 3. Epub 2012 Sep 3. PMID: 22943846
Article Published Date : Sep 02, 2012
Study Type : Human Study
Additional Links
Diseases : Insomnia, Postmenopausal Disorders: Insomnia
Therapeutic Actions : Acupuncture
[+]

A combination of valerian and hops reduces sleep latency in patients suffering from non-organic insomnia. Sep 01, 2007

Pubmed Data : Phytother Res. 2007 Sep;21(9):847-51. PMID: 17486686
Article Published Date : Sep 01, 2007
Study Type : Human Study
Additional Links
Substances : Hops, Valerian
Diseases : Insomnia
[+]

A single session of cognitive behavioral therapy for insomnia was found to be sufficiently efficacious for a significant proportion of those with acute insomnia. Dec 31, 2014

Pubmed Data : Sleep. 2015 ;38(6):971-8. Epub 2015 Jun 1. PMID: 25515106
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Insomnia, Sleep Disorders
Therapeutic Actions : Cognitive Behavioural Approaches
Additional Keywords : Significant Treatment Outcome
[+]

Acupoints massage may improve the quality of sleep and quality of life in patients with end-stage renal disease.Apr 01, 2003

Pubmed Data : J Adv Nurs. 2003 Apr;42(2):134-42. PMID: 12670382
Article Published Date : Apr 01, 2003
Study Type : Human Study
Additional Links
Diseases : Insomnia, Kidney Failure, Renal Disease: End-Stage
Therapeutic Actions : Acupressure, Massage/Therapeutic Touch
[+]

Acupressure has the potential to improve insomnia in residents of long-term care facilities. Sep 01, 2004

Pubmed Data : Rheumatol Int. 2004 Sep;24(5):278-82. Epub 2003 Sep 17. PMID: 20056221
Article Published Date : Sep 01, 2004
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupressure
[+]

Acupuncture has therapeutic value in the treatment of insomnia. Feb 01, 2010

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2010 Feb;8(2):126-30. PMID: 20141734
Article Published Date : Feb 01, 2010
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupuncture
[+]

Acupuncture in combination with foot massage is superior to Alprazolam in the treatment of insomnia. Oct 01, 2001

Pubmed Data : J Antimicrob Chemother. 2001 Oct;48(4):487-91. PMID: 18630537
Article Published Date : Oct 01, 2001
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupuncture, Massage/Therapeutic Touch
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Acupuncture may have therapeutic value in intractable insomnia. Mar 01, 2010

Pubmed Data : J Tradit Chin Med. 2010 Mar;30(1):21-2. PMID: 20397457
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupuncture
[+]

Acupuncture plus cupping for treating insomnia is therapeutic in college students.Dec 01, 2007

Pubmed Data : Med Sci Monit. 2007 Dec;13(12):BR286-92. PMID: 21053624
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupuncture, Moxibustion
[+]

Amber lenses represent a safe, affordable, and easily implemented therapeutic intervention for insomnia symptoms.Dec 31, 2017

Pubmed Data : J Psychiatr Res. 2018 Jan ;96:196-202. Epub 2017 Oct 21. PMID: 29101797
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Amber Lenses, Blue Light Blocking
Anti Therapeutic Actions : Blue Light (400−495 nm)
[+]

Aromatherapy massage may have some value in a hospice setting for reducing insomnia.Mar 01, 2004

Pubmed Data : Palliat Med. 2004 Mar;18(2):87-92. PMID: 15046404
Article Published Date : Mar 01, 2004
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Insomnia
Therapeutic Actions : Aromatherapy , Massage/Therapeutic Touch
[+]

Both melatonin and light treatment have positive effects on various sleep outcomes.Oct 09, 2016

Pubmed Data : Sleep. 2016 Oct 10. Epub 2016 Aug 10. PMID: 27748241
Article Published Date : Oct 09, 2016
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Insomnia, Sleep Disorders
Therapeutic Actions : Light Therapy
[+]

Cannabis may improve pain, mood and sleep in some patients with chronic pain.Jun 01, 2002

Pubmed Data : Pain Res Manag. 2002 Summer;7(2):95-9. PMID: 12185373
Article Published Date : Jun 01, 2002
Study Type : Human Study
Additional Links
Substances : Marijuana
Diseases : Insomnia, Pain
[+]

Cannabis-based medicine is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain and is mostly well tolerated.Sep 27, 2005

Pubmed Data : Neurology. 2005 Sep 27;65(6):812-9. PMID: 16186518
Article Published Date : Sep 27, 2005
Study Type : Human Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Insomnia, Multiple Sclerosis, Pain, Sleep Disorders
Pharmacological Actions : Analgesics
[+]

Cherry juice increased sleep time and sleep efficiency. Mar 26, 2017

Pubmed Data : Am J Ther. 2017 Mar 27. Epub 2017 Mar 27. PMID: 28901958
Article Published Date : Mar 26, 2017
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Tart Cherry
Diseases : Insomnia
Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation
[+]

Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime.Jul 01, 2002

Pubmed Data : Metabolism. 2002 Jul;51(7):887-92. PMID: 12077736
Article Published Date : Jul 01, 2002
Study Type : Human Study
Additional Links
Diseases : Insomnia
Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Classical music reduces sleeping problems in students. May 01, 2008

Pubmed Data : J Adv Nurs. 2008 May;62(3):327-35. PMID: 18426457
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Music
[+]

Cognitive behavioural therapy has beneficial effects for patients suffering from insomnia.Feb 13, 2017

Pubmed Data : Encephale. 2017 Feb 14. Epub 2017 Feb 14. PMID: 28213988
Article Published Date : Feb 13, 2017
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Meditation
[+]

Cognitive therapy and tai chi led to improvements in risk scores associated with cardiovascular, metabolic, and inflammatory disease risks. Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Psychoneuroendocrinology. 2015 May ;55:184-92. Epub 2015 Feb 25. PMID: 25770704
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Diseases : Chronic Disease, Insomnia
Therapeutic Actions : Cognitive Behavioural Approaches, Tai Chi
Additional Keywords : Risk Factors, Risk Reduction
[+]

Consumption of medical Cannabis flower is associated with significant improvements in perceived insomnia.Jul 10, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicines (Basel). 2018 Jul 11 ;5(3). Epub 2018 Jul 11. PMID: 29997343
Article Published Date : Jul 10, 2018
Study Type : Human Study
Additional Links
Substances : Cannabis
Diseases : Insomnia
[+]

Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients.Apr 01, 2009

Pubmed Data : Sleep Med. 2009 Apr;10(4):439-45. Epub 2008 Aug 27. PMID: 18755628
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Insomnia, Pineal Gland Calcification
Additional Keywords : Diseases that are Linked
[+]

Electroacupuncture appears to have therapeutic value in the treatment of primary insomnia. Aug 01, 2009

Pubmed Data : Sleep. 2009 Aug 1;32(8):1039-47. PMID: 19725255
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Electroacupuncture
[+]

Electroacupuncture treatment is beneficial for the treamtment of chronic insomniacs.Dec 05, 2009

Pubmed Data : Chin Med J (Engl). 2009 Dec 5;122(23):2869-73. PMID: 20092793
Article Published Date : Dec 05, 2009
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Electroacupuncture
[+]

Emotional freedom technique may be a new therapeutic approach for improving psychological and immunological factors.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Allergy Asthma Immunol. 2015 Feb ;14(1):37-47. PMID: 25530137
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Diseases : Anxiety, Insomnia
Therapeutic Actions : Emotional Freedom Technique
Pharmacological Actions : Anti-Anxiety Agents, Immunomodulatory, Interleukin-17 upregulation
[+]

Essential oil of lavender serves as a mild sedative and promotes deep sleep in young men and women.Jan 01, 2005

Pubmed Data : Chronobiol Int. 2005;22(5):889-904. PMID: 16298774
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Insomnia
[+]

Far-infrared rays are applied to acupoints were beneficial in patients with depression and insomnia. Dec 31, 2008

Pubmed Data : Am J Chin Med. 2009 ;37(5):837-42. PMID: 19885944
Article Published Date : Dec 31, 2008
Study Type : Human Study
Additional Links
Diseases : Depression, Insomnia
Therapeutic Actions : Thermal Therapy: Far-Infrared
Pharmacological Actions : Malondialdehyde Down-regulation
[+]

Grounding the human body during sleep lowers and resynchronizes cortisol levels Oct 01, 2004

Pubmed Data : J Altern Complement Med. 2004 Oct;10(5):767-76. PMID: 15650465
Article Published Date : Oct 01, 2004
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Cortisol: High, Insomnia, Stress
Therapeutic Actions : Grounding: Contact with the Earth
[+]

Homeopathic treatment appears to have therapeutic effects in the treatment of elderly patients.Jan 01, 2010

Pubmed Data : BMC Geriatr. 2010;10:10. Epub 2010 Feb 22. PMID: 20175887
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Aging, Hypertension, Insomnia
Therapeutic Actions : Homeopathic Treatment
[+]

Insomnia patients may have decreased nocturnal levels of ghrelin. May 01, 2009

Pubmed Data : Psychoneuroendocrinology. 2009 May;34(4):540-5. Epub 2008 Dec 6. PMID: 19059729
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Diseases : Ghrelin disorders, Insomnia
[+]

Kava and valerian root are effective in the treatment of stress-induced insomnia. Sep 01, 2001

Pubmed Data : Phytother Res. 2001 Sep;15(6):549-51. PMID: 11536390
Article Published Date : Sep 01, 2001
Study Type : Human Study
Additional Links
Substances : Kava Kava, Valerian
Diseases : Insomnia, Stress
[+]

Lavender fragrance had a beneficial effect on insomnia and depression in women college students.Sep 01, 1999

Pubmed Data : Br J Pharmacol. 1999 Sep;128(2):380-4. PMID: 16520572
Article Published Date : Sep 01, 1999
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Depression, Insomnia
Therapeutic Actions : Aromatherapy
[+]

Lavender fragrance is effective in treating mild insomnia. Aug 01, 2005

Pubmed Data : J Altern Complement Med. 2005 Aug;11(4):631-7. PMID: 16131287
Article Published Date : Aug 01, 2005
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Insomnia
Therapeutic Actions : Aromatherapy
[+]

Lettuce seed decreased insomnia during pregnancy and could be recommended as a safe natural remedy for treatment of pregnancy-related insomnia.Dec 04, 2018

Pubmed Data : J Ethnopharmacol. 2018 Dec 5 ;227:176-180. Epub 2018 Aug 30. PMID: 30172900
Article Published Date : Dec 04, 2018
Study Type : Human Study
Additional Links
Substances : Lettuce
Diseases : Insomnia
Pharmacological Actions : Hypnotics and Sedatives
Additional Keywords : Phytotherapy
[+]

Lovastatin has an adverse effect on sleep efficiency and sleep stages.Dec 01, 1991

Pubmed Data : Clin Pharmacol Ther. 1991 Dec ;50(6):730-7. PMID: 1752118
Article Published Date : Dec 01, 1991
Study Type : Human Study
Additional Links
Diseases : Insomnia, Sleep Disorders
Problem Substances : Lovastatin
[+]

Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months.Nov 30, 2017

Pubmed Data : Clin Chim Acta. 2017 Dec ;475:147-151. Epub 2017 Oct 26. PMID: 29080688
Article Published Date : Nov 30, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Insomnia, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

Melatonin significantly improves insomnia in patients aged 55 years or older. Jan 01, 2000

Pubmed Data : J Bone Miner Metab. 2000;18(4):216-22. PMID: 17875243
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Insomnia
[+]

Mobile phone exposure interferes with sleep patterns in subjects with mobile phone-related symptoms.Sep 20, 2010

Pubmed Data : Bioelectromagnetics. 2010 Sep 20. Epub 2010 Sep 20. PMID: 20857453
Article Published Date : Sep 20, 2010
Study Type : Human Study
Additional Links
Diseases : Insomnia, Mobile Phone-Induced Oxidative Stress, Sleep Disorders
Problem Substances : Cell Phone Exposure
[+]

Moxibustion is as effective as the benzodiazepine derivative Estrazolam for treating insomnia. Jun 01, 2009

Pubmed Data : J Tradit Chin Med. 2009 Jun;29(2):95-6. PMID: 19663092
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Moxibustion
Additional Keywords : Natural Substances Versus Drugs
[+]

Music improves sleep quality in older adults.Feb 01, 2005

Pubmed Data : J Adv Nurs. 2005 Feb;49(3):234-44. PMID: 15660547
Article Published Date : Feb 01, 2005
Study Type : Human Study
Additional Links
Diseases : Aging, Insomnia
Therapeutic Actions : Music
[+]

Napping and an extended duration of recovery sleep has a positive effect on alertness and immune cells after acute sleep restriction.Jan 01, 2011

Pubmed Data : Brain Behav Immun. 2011 Jan ;25(1):16-24. Epub 2010 Aug 8. PMID: 20699115
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Atherosclerosis, Inflammation, Insomnia
Therapeutic Actions : Napping
[+]

Neurexan might be an effective and well-tolerated alternative to conventional valerian-based therapies for the treatment of mild to moderate insomnia.Dec 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2008 ;8:411-20. Epub 2008 Apr 20. PMID: 18454251
Article Published Date : Dec 31, 2007
Study Type : Human Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Insomnia
Additional Keywords : Homeopathic Vs. Conventional Treatment, Phytotherapy, Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Oral intake of A. citriodora can be suggested as a complementary treatment for patients with insomnia.Nov 18, 2018

Pubmed Data : Phytother Res. 2018 Nov 19. Epub 2018 Nov 19. PMID: 30450627
Article Published Date : Nov 18, 2018
Study Type : Human Study
Additional Links
Substances : Lemon Verbena
Diseases : Insomnia
[+]

Overnight acupressure wrist compression ameliorate quality of sleep and reduce anxiety levels in insomniacs. Dec 01, 2008

Pubmed Data : Minerva Med. 2008 Dec;99(6):539-47. PMID: 19034253
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupressure
[+]

Self-administered acupressure taught in a short training course may be a feasible approach to improve insomnia.Sep 07, 2017

Pubmed Data : J Sleep Res. 2017 Sep 8. Epub 2017 Sep 8. PMID: 28884877
Article Published Date : Sep 07, 2017
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupressure
Additional Keywords : Acupressure, insomnia
[+]

Sleep fragmentation is associated with adverse health effects.Jul 27, 2011

Pubmed Data : Am J Clin Nutr. 2011 Jul 27. Epub 2011 Jul 27. PMID: 21795436
Article Published Date : Jul 27, 2011
Study Type : Human Study
Additional Links
Diseases : Fatigue, Insomnia, Overweight
[+]

Smoked cannabis reduces the intensity of pain and improves sleep in those with chronic neuropathic pain.Oct 05, 2010

Pubmed Data : CMAJ. 2010 Oct 5;182(14):E694-701. Epub 2010 Aug 30. PMID: 20805210
Article Published Date : Oct 05, 2010
Study Type : Human Study
Additional Links
Substances : Cannabis
Diseases : Insomnia, Neuropathic Pain, Pain
[+]

Supplementation of magnesium appears to improve subjective measures of insomnia.Nov 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Res Med Sci. 2012 Dec ;17(12):1161-9. PMID: 23853635
Article Published Date : Nov 30, 2012
Study Type : Human Study
Additional Links
Substances : Magnesium
Diseases : Insomnia
[+]

Tai Chi improves sleep quality in older adults with moderate sleep complaints. Jul 01, 2008

Pubmed Data : Sleep. 2008 Jul 1;31(7):1001-8. PMID: 18652095
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Tai Chi
[+]

Tart cherry juice may help older adults with insomnia.Jun 01, 2010

Pubmed Data : J Med Food. 2010 Jun;13(3):579-83. PMID: 20438325
Article Published Date : Jun 01, 2010
Study Type : Human Study
Additional Links
Substances : Tart Cherry
Diseases : Insomnia
[+]

The association between insomnia, c-reactive protein, and chronic low back pain.Jul 08, 2019

Pubmed Data : Scand J Pain. 2019 Jul 9. Epub 2019 Jul 9. PMID: 31287802
Article Published Date : Jul 08, 2019
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein (CRP), Inflammation, Insomnia, Low Back Pain
[+]

The consumption of a tart cherry juice concentrate provides an increase in exogenous melatonin that is beneficial in improving sleep duration and quality in healthy men and women.Oct 30, 2011

Pubmed Data : Eur J Nutr. 2011 Oct 30. Epub 2011 Oct 30. PMID: 22038497
Article Published Date : Oct 30, 2011
Study Type : Human Study
Additional Links
Substances : Tart Cherry
Diseases : Hormone Imbalances: Low Melatonin, Insomnia, Sleep Disorders
[+]

These findings support the hypothesis that migraine is a consequence of a loss of neurohormonal and metabolic integrity.Dec 31, 2014

Pubmed Data : Neuro Endocrinol Lett. 2015 ;36(5):421-9. PMID: 26707041
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Magnesium
Diseases : Depression, Fatigue, Fibromyalgia, Headache: Migraine, Insomnia
Therapeutic Actions : Hormone Replacement Therapy
Additional Keywords : Microbiota, Significant Treatment Outcome
[+]

These results suggest that a Mediterranean-style diet is associated with adequate sleep duration and less insomnia symptoms.Aug 21, 2018

Pubmed Data : Sleep. 2018 Aug 22. Epub 2018 Aug 22. PMID: 30137563
Article Published Date : Aug 21, 2018
Study Type : Human Study
Additional Links
Diseases : Insomnia
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

Tryptophan-rich gourd seeds significantly improve subjective and objective measurements of insomnia.Apr 01, 2005

Pubmed Data : Nutr Neurosci. 2005 Apr;8(2):121-7. PMID: 16053244
Article Published Date : Apr 01, 2005
Study Type : Human Study
Additional Links
Substances : Gourd, Pumpkin Seed Oil/Meal, Tryptophan
Diseases : Insomnia
[+]

Valerian extract is comparable to the drug oxazepam in the treatment of non-organic insomnia. Nov 25, 2002

Pubmed Data : Eur J Med Res. 2002 Nov 25;7(11):480-6. PMID: 12568976
Article Published Date : Nov 25, 2002
Study Type : Human Study
Additional Links
Substances : Valerian
Diseases : Insomnia
Additional Keywords : Natural Substances Versus Drugs
[+]

Valerian improves sleep quality in postmenopausal women. Jul 14, 2011

Pubmed Data : Menopause. 2011 Jul 14. Epub 2011 Jul 14. PMID: 21775910
Article Published Date : Jul 14, 2011
Study Type : Human Study
Additional Links
Substances : Valerian
Diseases : Insomnia, Postmenopausal Disorders
[+]

Valerian significantly improves sleep in a randomized human trial. Apr 01, 1989

Pubmed Data : Pharmacol Biochem Behav. 1989 Apr;32(4):1065-6. PMID: 2678162
Article Published Date : Apr 01, 1989
Study Type : Human Study
Additional Links
Substances : Valerian
Diseases : Insomnia
[+]

Viewing humorous film improves nighttime wakening in children with atopic dermatitis.Apr 01, 2007

Pubmed Data : Indian Pediatr. 2007 Apr;44(4):281-5. PMID: 17468523
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Diseases : Atopic Dermatitis, Insomnia
Therapeutic Actions : Laughter/Humor
[+]

Women receiving aromatherapy experienced a significant improvement in sleep quality after intervention. However, lavender aromatherapy does not appear to confer benefit on heart rate variability (HRV) in the long-term followupJan 01, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:740813. Epub 2011 Aug 18. PMID: 21869900
Article Published Date : Jan 01, 2012
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Insomnia
Therapeutic Actions : Aromatherapy
[+]

Cannabidiol oil could be used as a safe treatment for reducing anxiety and improving sleep in posttraumatic stress disorders.Oct 11, 2016

Pubmed Data : Perm J. 2016 Oct 12 ;20(4). Epub 2016 Aug 12. PMID: 27768570
Article Published Date : Oct 11, 2016
Study Type : Human: Case Report
Additional Links
Substances : Cannabidiol
Diseases : Anxiety Disorders, Insomnia, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Anti-Anxiety Agents
[+]

Dramatic decreases in fatigue and insomnia were observed, as well as increased cognitive functioning. Jan 23, 2014

Pubmed Data : N Z Med J. 2014 Jan 24 ;127(1388):66-70. Epub 2014 Jan 24. PMID: 24481389
Article Published Date : Jan 23, 2014
Study Type : Human: Case Report
Additional Links
Substances : Vitamin C
Diseases : Breast Cancer, Fatigue: Cancer-Associated, Insomnia
Pharmacological Actions : Chemotherapeutic
[+]

"Valeriana wallichii root extract improves sleep quality and modulates brain monoamine level in rats."Jul 14, 2012

Pubmed Data : Phytomedicine. 2012 Jul 15 ;19(10):924-9. Epub 2012 Jul 4. PMID: 22766307
Article Published Date : Jul 14, 2012
Study Type : Animal Study
Additional Links
Substances : Valerian
Diseases : Insomnia
Pharmacological Actions : Monoaminergic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Aloe vera extract has sedative-hypnotic effects in animals. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2016 ;15(1):293-300. PMID: 27610170
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Insomnia, Sleep Disorders
Pharmacological Actions : Hypnotics and Sedatives
Additional Keywords : Plant Extracts
[+]

Ashwagandha may serve as an effective dietary supplement for management of sleep deprivation induced stress and associated functional impairments.Dec 20, 2016

Pubmed Data : Mol Cell Biochem. 2016 Dec 21. Epub 2016 Dec 21. PMID: 28004351
Article Published Date : Dec 20, 2016
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Brain Inflammation , Insomnia, Sleep Disorders
Pharmacological Actions : Anti-Anxiety Agents, Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Cell phone radiation exposure is associated with a broad range of brain protein changes which may explain the association between cell phone use and adverse health effects.Jan 20, 2012

Pubmed Data : Electromagn Biol Med. 2012 Jan 20. Epub 2012 Jan 20. PMID: 22263702
Article Published Date : Jan 20, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain Cancer, Fatigue, Headache, Insomnia, Memory Disorders
Anti Therapeutic Actions : Electromagnetic Fields
Problem Substances : Cell Phone Exposure
[+]

Crocin and crocetin significantly increased the total time of non-rapid eye movement (non-REM) sleep after the administration.Jan 31, 2012

Pubmed Data : Mol Nutr Food Res. 2012 Feb ;56(2):304-8. Epub 2011 Oct 28. PMID: 22038919
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocetin, Crocin, Saffron
Diseases : Delayed Sleep Phase Disorder, Insomnia, Sleep Disorders
Additional Keywords : Dose Response
[+]

Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion.Jan 01, 2007

Pubmed Data : Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E253-61. Epub 2006 Aug 29. PMID: 16940468
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cortisol: High, Insomnia
Therapeutic Actions : Napping
Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Insufficient or poor-quality sleep may worsen pain and this enhanced pain may not be reduced by analgesics in mice.May 07, 2017

Pubmed Data : Nat Med. 2017 May 8. Epub 2017 May 8. PMID: 28481358
Article Published Date : May 07, 2017
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Insomnia, Sleep Disorders
Additional Keywords : Increased Risk
[+]

Kava kava improves sleep quality in sleep-disturbed rats.Jul 01, 2005

Pubmed Data : Psychopharmacology (Berl). 2005 Jul;180(3):564-9. Epub 2005 Feb 8. PMID: 15700178
Article Published Date : Jul 01, 2005
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Diseases : Insomnia
Pharmacological Actions : Hypnotics and Sedatives
Additional Keywords : Plant Extracts
[+]

Melatonin prevented memory impairment that was induced by Sleep deprivation.Jun 17, 2015

Pubmed Data : Mol Neurobiol. 2015 Jun 18. Epub 2015 Jun 18. PMID: 26084441
Article Published Date : Jun 17, 2015
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Insomnia, Memory Disorders, Sleep Disorders
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Chronobiotic
[+]

Nitric oxide modulation is involved in the protective effect of curcumin in ameliorating sleep deprivation-induced behavioral alterations and oxidative damage.Oct 01, 1997

Pubmed Data : IEEE Trans Biomed Eng. 1997 Oct;44(10):909-20. PMID: 18586477
Article Published Date : Oct 01, 1997
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Anxiety Disorders, Insomnia, Oxidative Stress
[+]

Oleuropein has anti-inflammatory, analgesic and sedative effects both in vitro and in vivo.Jan 30, 2019

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2019 Jan 31 ;65(1):52-55. Epub 2019 Jan 31. PMID: 30782294
Article Published Date : Jan 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oleuropein, Olive
Diseases : Inflammation, Insomnia
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hypnotics and Sedatives, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Procyanidin B2 from lotus seedpod regulate NO/ADMA/DDAH pathway to treat insomnia in rats.Mar 11, 2019

Pubmed Data : Fundam Clin Pharmacol. 2019 Mar 12. Epub 2019 Mar 12. PMID: 30861604
Article Published Date : Mar 11, 2019
Study Type : Animal Study
Additional Links
Substances : Procyanidin B2
Diseases : Insomnia
Pharmacological Actions : Antioxidants
[+]

Schisandra possesses potent sedative and hypnotic activity, which supports its therapeutic use for insomnia. Apr 04, 2007

Pubmed Data : J Ethnopharmacol. 2007 Apr 4;110(3):471-5. Epub 2006 Oct 19. PMID: 17127021
Article Published Date : Apr 04, 2007
Study Type : Animal Study
Additional Links
Substances : Schisandra
Diseases : Insomnia
Pharmacological Actions : Hypnotics and Sedatives
[+]

Tai chi appears to be effective as a nonpharmacological approach to sleep enhancement for sleep-disturbed elderly individuals.Jun 01, 2004

Pubmed Data : J Am Geriatr Soc. 2004 Jun;52(6):892-900. PMID: 15161452
Article Published Date : Jun 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Insomnia, Sleep Disorders
Therapeutic Actions : Tai Chi
[+]

Ziziphus spinosa induces sleep through its sedative and hypnotic effecs. Apr 01, 2007

Pubmed Data : Nat Prod Res. 2007 Apr;21(4):310-20. PMID: 17479419
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Ziziphus spinosa
Diseases : Insomnia
Pharmacological Actions : Hypnotics and Sedatives
[+]

A meta-analysis of 16 studies indicates that Valerian root might improve sleep quality without producing side effects. Dec 01, 2006

Pubmed Data : Am J Med. 2006 Dec;119(12):1005-12. PMID: 17145239
Article Published Date : Dec 01, 2006
Study Type : Review
Additional Links
Substances : Valerian
Diseases : Insomnia
[+]

Acupuncture is effective in improving sleep quality in patients with insomnia. Dec 01, 2007

Pubmed Data : Zhongguo Zhen Jiu. 2007 Dec;27(12):886-8. PMID: 18271228
Article Published Date : Dec 01, 2007
Study Type : Commentary
Additional Links
Diseases : Insomnia
Therapeutic Actions : Acupuncture
Additional Keywords : Natural Therapy Versus Drug
[+]

Magnolia and Ziziphus extracts modulate central nervous system receptors in a manner consistent with their traditional use as anxiolytic and sleep-inducing. Jul 30, 2009

Pubmed Data : J Ethnopharmacol. 2009 Jul 30;124(3):421-5. Epub 2009 Jun 6. PMID: 19505549
Article Published Date : Jul 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Magnolia, Ziziphus spinosa
Diseases : Anxiety Disorders, Insomnia
Pharmacological Actions : Anxiolytic, Benzodiazepine receptor agonist
Additional Keywords : Benzodiazepine Receptor Agonist
[+]

Music-assisted relaxation to improve sleep quality.Jul 01, 2009

Pubmed Data : J Adv Nurs. 2009 Jul;65(7):1356-64. Epub 2009 Apr 28. PMID: 19456998
Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Diseases : Insomnia
[+]

The role of microbiome in insomnia, circadian disturbance and depression.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Psychiatry. 2018 ;9:669. Epub 2018 Dec 5. PMID: 30568608
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Diseases : Circadian Dysregulation, Depression, Insomnia
Additional Keywords : Microbiome
[+]

This review aims to provide the latest information on specific functional components of Passiflora incarnata L.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Menopausal Med. 2017 Dec ;23(3):156-159. Epub 2017 Dec 29. PMID: 29354614
Article Published Date : Nov 30, 2017
Study Type : Review
Additional Links
Substances : Passion Flower
Diseases : Anxiety, Dysmenorrhea, Inflammation, Insomnia
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents
[+]

Valerian root may be beneficial in reducing insomnia associated with oxidative stress. Aug 01, 2009

Pubmed Data : Neurochem Res. 2009 Aug;34(8):1372-9. Epub 2009 Feb 4. PMID: 19191025
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Valerian
Diseases : Insomnia
Pharmacological Actions : Neuroprotective Agents
[+]

Foot Reflexology (Wooden needle technique) is superior to the drug Alprazolam in the treatment of insomnia. Nov 01, 2009

Pubmed Data : Zhongguo Zhen Jiu. 2009 Nov;29(11):935-7. PMID: 19994698
Article Published Date : Nov 01, 2009
Additional Links
Diseases : Insomnia
Additional Keywords : Drug: Alprazolam, Therapeutic Action Superior to Drug Therapy

Copyright: ocusfocus / 123RF Stock Photo

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