Liver Damage

Name	AC	CK
Curcumin	59	121
Silymarin	9	26
Ginsenosides	14	25
Milk Thistle	3	24
Nigella sativa (aka Black Seed)	12	22
Polyphenols	12	22
Puerarin	11	21
Thymoquinone	11	20
Resveratrol	8	18
Vitamin C	10	18
Anthocyanins	8	16
Flavonoids	9	16
Melatonin	5	16
Silibinin	4	15
Turmeric	7	14
Dandelion	6	12
Ginger	6	12
Turmeric: Fermented	2	12
Phyllanthus urinaria	2	11
Rose	6	11
Black Tea	5	10
Fermented Foods and Beverages	5	10
Grape Seed Extract	5	10
Sesamol	3	10
Naringenin	5	9
Olive leaf extract	5	9
Sulforaphane	6	9
Alpha-Lipoic Acid	4	8
Asiatic Acid	4	8
Bael	4	8
Beet	4	8
Blueberry	4	8
Camel Milk	4	8
Diallyl sulfide	4	8
Ellagic Acid	4	8
Garlic	4	8
Geraniol	4	8
Honey	4	8
Lycopene	4	8
Mangiferin	3	8
Radish	5	8
Reishi Mushroom	4	8
Sweet Potato: Purple	4	8
Vitamin D	4	8
Astaxanthin	4	7
Fucoidan	4	7
Carrot	3	6
Carvacrol	3	6
Catechin	3	6
Chlorella (Algae)	2	6
Date Seeds	2	6
Dates	3	6
Diosmin	3	6
Fenugreek	3	6
Genistein	3	6
Gingerol	3	6
Ginkgo biloba	2	6
Green Tea	3	6
Jujube	3	6
Lactobacillus plantarum	3	6
Olive Oil	3	6
Pomegranate	3	6
Quercetin	3	6
Royal Jelly	2	6
Sea buckthorn	3	6
Shikonin	3	6
Solanum nigrum (black nightshade)	3	6
Vitamin E	3	6
Yellow Tea	3	6
Zataria multiflora	3	6
Artichoke	3	5
Citrus naringin	3	5
EGCG (Epigallocatechin gallate)	3	5
Fig	3	5
Genipin	3	5
Indole-3-Carbinol	3	5
NAC (N-acetyl-L-cysteine)	3	5
Rosemary	3	5
Apple Polyphenols	2	4
Apricot	2	4
Artesunate	1	4
Ayurvedic formulation: Liv52	2	4
Beeswax	2	4
Berberine	2	4
Berries: All	2	4
Blue Honeysuckle	2	4
Caffeic acid phenethyl ester	2	4
Chlorogenic Acid	2	4
Choline	2	4
Citrus Peel	2	4
Cranberry	2	4
Crocin	2	4
DHA (Docosahexaenoic Acid)	2	4
Dill	2	4
EPA (Eicosapentaenoic Acid)	2	4
Embelia ribes	2	4
Garlic: Aged	2	4
Henna	2	4
Hesperidin	2	4
Hibiscus sabdariffa	2	4
Hu Zhang (Polygonum cuspidatum)	1	4
Hydrogen Water	2	4
Hydroxytyrosol	2	4
Isoliquiritigenin	2	4
Juniper	2	4
Kombucha Tea	3	4
Lactobacillus casei	2	4
Litchi	2	4
Lotus	3	4
Luteolin	2	4
Lychee	2	4
Myricetin	2	4
Noni	2	4
Onion	2	4
Papaya	2	4
Passion Flower	2	4
Phloretin	3	4
Piceatannol	2	4
Pomegranate Peel	2	4
Pomegranate Seed	2	4
Potato	2	4
Propolis: Bee	2	4
Rooibos	2	4
Saffron	2	4
Selenium	2	4
Shiitake Mushroom	2	4
Stevia	2	4
Verbascoside	2	4
White Tea	2	4
Xanthohumol	2	4
Yeast	2	4
Zinc	2	4
Amygdalin (laetrile)	2	3
Chaga Mushroom (Inonotus obliquus)	2	3
D-Limonene	2	3
Lactobacillus fermentum	2	3
Lignans	2	3
Mulberry	2	3
Oleanolic acid	2	3
Thistle	2	3
Ursolic Acid	2	3
Ajwain	1	2
Almond	1	2
Andrographis	1	2
Anise	1	2
Antrodia camphorata	1	2
Apigenin	1	2
Apocynin	1	2
Apples	1	2
Apricot Kernel	1	2
Arginine	1	2
Ashwagandha	1	2
Baccharis trimera	1	2
Bacopa	1	2
Bamboo	1	2
Banana Peel	1	2
Banana Stem	1	2
Barberry	1	2
Barley	1	2
Beta-Caryophyllene	1	2
Bilberry	1	2
Bile salts	1	2
Bitter Apple	1	2
Bitter Melon	1	2
Black Currant	1	2
Black Raspberry	1	2
Black Tea Theaflavins	1	2
Broccoli Sprouts	1	2
Bromelain	1	2
Burdock	1	2
Butterbur	1	2
Cabbage	1	2
Caffeine	1	2
Cannabidiol	1	2
Capsaicin	1	2
Carotenoids	1	2
Celery	1	2
Celosia cristata (cockscomb)	1	2
Centella asiatica	1	2
Chamomile	1	2
Chickpea	1	2
Chicory	1	2
Chrysanthemum Indicum	1	2
Chrysin	1	2
Cinnamon	1	2
Cissus quadrangularis	1	2
Coconut Oil	1	2
Coconut Water	1	2
Coenzyme Q10	1	2
Coffee: Green/Unroasted	1	2
Cordyceps sinensis	1	2
Coriandrum sativum	1	2
Cucurbitacin B	1	2
Cumin	1	2
Cysteine (see N-Acetylcysteine)	1	2
Dibenzoylmethane (DBM)	1	2
Earthworms	1	2
Echinacea	1	2
Eggplant	1	2
Elderberry	1	2
Emodin	1	2
Eriodictyol	1	2
Feverfew	1	2
Fisetin	1	2
Fish Oil	1	2
Flaxseed	1	2
Folic Acid	1	2
Gallic Acid	1	2
Garden Cress (Lepidium sativum)	1	2
Geranium	1	2
Ginseng	1	2
Glycyrrhizin	1	2
Goat Milk	1	2
Goji	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Gotu Kola	1	2
Grape	1	2
Guava	1	2
Guduchi	1	2
Hibiscus rosa-sinensis	1	2
Hops	1	2
Horehound	1	2
Kimchi	1	2
Lactobacillus probiotics	1	2
Lactobacillus reuteri	1	2
Lactobacillus rhamnosus GG	1	2
Lactobacillus salivarius	1	2
Ligustrazine	1	2
Long Pepper	1	2
Loquat Seeds	1	2
Lutein	1	2
Magnesium	1	2
Mango	1	2
Medicinal Mushrooms	1	2
Mint	1	2
Miso	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Myrica rubra	1	2
Nettle	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Nobiletin	1	2
Nutmeg	1	2
Oak	1	2
Okra	1	2
Oleuropein	1	2
Olive	1	2
Orange	1	2
Oregano	1	2
Oyster Mushroom	1	2
Paeoniflorin	1	2
Palash	1	2
Palmitoylethanolamide	1	2
Panax Notoginseng	1	2
Peppermint	1	2
Phosphatidylcholine	1	2
Pine Bark Extract	1	2
Piper cubeba (Cubeb)	1	2
Piperine	1	2
Plant Stem Cells	1	2
Proanthocyanidins	1	2
Probiotics	1	2
Prunella vulgaris	1	2
Pterocarpus marsupium	1	2
Pterostilbene	1	2
Pumpkin Seed Oil/Meal	1	2
Purslane	1	2
Raspberry	1	2
Red Cabbage	1	2
Rice Bran	1	2
Rice: Brown	1	2
Rice: Parboiled	1	2
Rosemaric Acid	1	2
Sage	1	2
Saikosaponin	1	2
Salvia miltiorrhiza	1	2
Semecarpus anacardium	1	2
Sesame Seed Oil	1	2
Sessile Joyweed	1	2
Silica Hydride	1	2
Soy	1	2
Spirulina	1	2
Stilbenes	1	2
Strawberry	1	2
Tannic Acid	1	2
Taro	1	2
Taurine	1	2
Thymol	1	2
Tyrosine	1	2
Urine	1	2
Urine: Cow	1	2
Vanillin	1	2
Vitexins	1	2
Walnut	1	2
Water: Deuterium Depleted	1	2
Water: Electrolyzed Reduced	1	2
Yoghurt	1	2
Agrimony	1	1
Allicin	1	1
Astragaloside	1	1
Blackberry	1	1
Caraway	1	1
Coffee	1	1
Coriandor	1	1
Curcuminoids	1	1
Cyperus longus	1	1
Gynostemma	1	1
Haritaki (Terminalia chebula)	1	1
Honokiol	1	1
Kudzu	1	1
Lavender	1	1
Licorice	1	1
Lupeol	1	1
Prickly Pear Cactus	1	1
Rice: Black	1	1
Tanshinone IIA	1	1
Tetrahydrocurcumin	1	1
Vitex negundo	1	1
Wheat Grass	1	1
White Mulberry	1	1

Name	AC	CK
Statin Drugs	22	124
Paracetamol	51	95
Acetaminophen	49	91
Simvastatin	9	77
Atorvastatin	12	69
Isoniazid	4	62
Pravastatin	5	45
Bisphenol A	14	41
Fluvastatin	3	40
Lovastatin	7	36
Aflatoxin	10	27
High Fructose Corn Syrup	5	18
Rosuvastatin	4	17
Concanavalin A	7	16
Cadmium	9	15
Tylenol	2	14
Perfluorooctanoic acid (PFOA)	2	12
Tamoxifen	3	12
Fluoroquinolone Antibiotic	1	10
Proton-Pump Inhibitors	1	10
Fluoxetine (trade name Prozac)	4	9
Mercury	3	9
Pesticides	5	9
Morphine	4	8
Tertiary butyl hydroperoxide	6	7
2-chlorobenzylidene malononitrile (CS)	1	6
Arsenic	4	6
Aspartame	3	6
Glyphosate	4	6
Quizalofop-P-ethyl	1	6
Bisphenol S	3	5
Aluminum	2	4
Arsenite	2	4
Benzo(a)pyrene	2	4
Butylated Hydroxytoluene (BHT)	2	4
Cisplatin	2	4
Dichlorvos	2	4
Electronic Cigarettes	2	4
Formaldehyde	2	4
Fructose	2	4
Lead	2	4
Monosodium Glutamate (MSG)	2	4
N-nitrosodiethylamine	2	4
Nanoparticles	2	4
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	4
Organophosphate Pesticides	2	4
Perfluorooctane sulfonate (PFOS)	2	4
Rosiglitazone (trade name Avandia)	2	4
Sodium Fluoride	2	4
Acrylamide	2	3
Cerivastatin	1	3
Cholesterol Lowering Drugs	1	3
Fenofibrates	1	3
Fluconazole	1	3
Zinc Oxide	2	3
Aluminum Hydroxide	1	2
Antibiotics	1	2
Arsenic Trioxide	1	2
Brilliant Blue FCF	1	2
Chlorpyrifos	1	2
Cypermethrin	1	2
Dexamethasone	1	2
Diclofenac	1	2
Erythrosine	1	2
Ethylene Glycol	1	2
FD&C Red #40	1	2
Food Colorings	1	2
Insulin	1	2
Metanil-Yellow Dye	1	2
N-nitrosodimethylamine	1	2
Organophosphates	1	2
Paclitaxel	1	2
Ponceau 4R (New Coccine)	1	2
Selective Serotonin Reuptake Inhibitors (SSRIs)	1	2
Sucralose (aka Splenda)	1	2
Sucrose	1	2
Sugar Sweetened Beverages	1	2
Tartrazine (Yellow Food Dye)	1	2
Thiazolidinediones	1	2
Titanium Dioxide	1	2
Titanium Nanoparticles	1	2
Toluene	1	2
Trans Fatty Acids	1	2
Vaccine Adjuvants	1	2
Zoledronic Acid	1	2
Amiodarone	1	1
Dimethoate	1	1
Irinotecan	1	1
Methotrexate	1	1
Parabens	1	1
Triclosan	1	1
Zineb	1	1

Name	AC	CK
Western Diet	2	4
Electromagnetic Fields	1	2
Mobile Phone Radiation	1	2
Vaccination: All	1	2
Vaccination: Hepatitis B	1	2
Nanotechnology	1	1

[+]

Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2013 ;13:58. Epub 2013 Mar 8. PMID: 23497020

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Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pak J Med Sci. 2020 Mar-Apr;36(3):445-450. PMID: 32292450

Article Published Date : Feb 29, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Hepatitis C, Liver Damage, Vitamin D Deficiency

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Hepatoprotective

Additional Keywords : Increased Risk

[+]

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID: 28071871

Article Published Date : Jan 31, 2017

Study Type : Human In Vitro

Additional Links

Substances : Mangiferin

Diseases : Chemically-Induced Liver Damage, Mercury Poisoning, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Additional Keywords : Methylmercury

Problem Substances : Mercury

[+]

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

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Pubmed Data : Gastroenterol Clin Biol. 1991 ;15(1):94-5. PMID: 2010080

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Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141

Article Published Date : May 18, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage, Cholestasis, Hepatitis: Cholestatic, Statin-Induced Pathologies

Problem Substances : Cerivastatin, Statin Drugs

Adverse Pharmacological Actions : Hepatotoxic

[+]

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

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Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Recenti Prog Med. 1991 Apr ;82(4):233-5. PMID: 1857844

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Prev Med. 2017 Jun 12 ;22(1):54. Epub 2017 Jun 12. PMID: 29165178

Article Published Date : Jun 11, 2017

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:838-844. Epub 2018 Sep 24. PMID: 30372895

Article Published Date : Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Pubmed Data : Environ Toxicol. 2020 Feb 25. Epub 2020 Feb 25. PMID: 32096903

Article Published Date : Feb 24, 2020

Study Type : Animal Study

Additional Links

Substances : Eugenol

Diseases : Chemically-Induced Liver Damage, Pesticide Toxicity

Therapeutic Actions : Exercise: Aerobic

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Chlorpyrifos

[+]

Aged black garlic has hepatoprotective effects and suggests that supplementation might be a good adjuvant therapy for the management of liver injury.Feb 28, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Chem Biol Interact. 2010 Apr 29;185(2):101-9. Epub 2010 Mar 6. PMID: 20211157

Article Published Date : Apr 29, 2010

Study Type : Animal Study

Additional Links

Substances : Almond, Catechin

Diseases : Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Alpha lipoic acid possess protective effects against chlorpyrifos induced liver injury.Feb 22, 2018

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Pubmed Data : Environ Toxicol Pharmacol. 2018 Feb 23 ;59:17-23. Epub 2018 Feb 23. PMID: 29500983

Ameliorative effects of honey, propolis, pollen, and royal jelly mixture against chronic toxicity of sumithion insecticide.Jun 04, 2020

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Pubmed Data : Molecules. 2020 Jun 5 ;25(11). Epub 2020 Jun 5. PMID: 32517066

Article Published Date : Jun 04, 2020

Study Type : Animal Study

Additional Links

Substances : Bee Pollen, Bee Propolis, Honey, Royal Jelly

Diseases : Chemically-Induced Liver Damage, Kidney Damage, Pesticide Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Pesticides

[+]

Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity.Feb 19, 2019

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Pubmed Data : Drug Chem Toxicol. 2019 Feb 20:1-7. Epub 2019 Feb 20. PMID: 30782023

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2015 Feb ;18(2):205-11. PMID: 25825639

[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Arctium lappa root extract prevents lead-induced liver injury.Nov 23, 2019

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Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282

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Pubmed Data : Springerplus. 2016 ;5:216. Epub 2016 Feb 29. PMID: 27026910

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Atorvastatin may contribute to hepatopathy through suppressing oxidized and reduce coenzyme q10 and mitochondrial function in the liver. Apr 20, 2012

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Pubmed Data : Physiol Res. 2012 Apr 20 ;61(2):185-93. Epub 2012 Jan 31. PMID: 22292717

Article Published Date : Apr 20, 2012

Study Type : Animal Study

Additional Links

Diseases : Liver Damage: Drug-Induced, Statin-Induced Pathologies

Problem Substances : Atorvastatin

Adverse Pharmacological Actions : Hepatotoxic

[+]

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

Article Published Date : Aug 19, 2018

Study Type : Animal Study

Additional Links

Substances : Bael , Piperine

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

B. trimera a potential candidate drug capable of protecting the liver against damage caused by Acetaminophen overdose.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2014 ;2014:196598. Epub 2014 Nov 12. PMID: 25435714

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Baccharis trimera

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

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Pubmed Data : Heliyon. 2016 Feb ;2(2):e00068. Epub 2016 Feb 15. PMID: 27441247

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Pubmed Data : Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID: 27455313

Article Published Date : Jul 20, 2016

Study Type : Animal Study

Additional Links

Substances : Barley

Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Bees' honey attenuation of metanil-yellow-induced hepatotoxicity in rats.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:614580. Epub 2013 Jun 3. PMID: 23818929

Article Published Date : Dec 31, 2012

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Pubmed Data : Food Chem Toxicol. 2012 Jun ;50(6):2027-33. Epub 2012 Mar 24. PMID: 22465004

Article Published Date : May 31, 2012

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage, DNA damage

Pharmacological Actions : Hepatoprotective

Problem Substances : N-nitrosodiethylamine

Adverse Pharmacological Actions : Hepatotoxic

[+]

Beetroot protects the liver against chemical toxicity.Feb 01, 2006

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Pubmed Data : Fitoterapia. 2006 Feb;77(2):91-3. Epub 2005 Dec 20. PMID: 16376022

Article Published Date : Feb 01, 2006

Study Type : Animal Study

Additional Links

Substances : Beet

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Beetroot water extract could be used following silver nano particles as a potential therapeutic intervention to minimize liver toxicity.Dec 31, 2019

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Pubmed Data : Int J Nanomedicine. 2020 ;15:3471-3482. Epub 2020 May 15. PMID: 32547008

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Berberine protects against the hepatic damage induced by ParacetamolFeb 01, 2000

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Pubmed Data : Fitoterapia. 2000 Feb ;71(1):25-33. PMID: 11449466

Pubmed Data : Environ Pollut. 2020 Dec 22 ;271:116304. Epub 2020 Dec 22. PMID: 33401208

Article Published Date : Dec 21, 2020

Study Type : Animal Study

Additional Links

Diseases : Bisphenol Toxicity, Chemically-Induced Liver Damage, Nonalcoholic fatty liver disease (NAFLD)

Problem Substances : Bisphenol F

[+]

Bisphenol S-induced chronic inflammatory stress in liver.Feb 28, 2019

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Pubmed Data : Environ Pollut. 2019 Mar ;246:963-971. Epub 2018 Dec 24. PMID: 31159146

Article Published Date : Feb 28, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Bisphenol Toxicity, Inflammation, Liver Damage, Oxidative Stress

Problem Substances : Bisphenol S

[+]

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

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Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728

Article Published Date : Jun 07, 2010

Study Type : Animal Study

Additional Links

Substances : Blueberry

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

[+]

Both Nigella sativa and date reduce the toxic effects of aflatoxin-B1 in liver and kidney.Jun 30, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Health Sci (Qassim). 2008 Jul ;2(2):26-44. PMID: 21475486

Article Published Date : Jun 30, 2008

Study Type : Animal Study

Additional Links

Substances : Dates, Nigella sativa (aka Black Seed)

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Aflatoxin

[+]

Boysenberry anthocyanins is a food component available to prevent liver injury.Dec 31, 2003

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Pubmed Data : Biofactors. 2004 ;21(1-4):259-61. PMID: 15630207

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Propolis: Brazillian

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Brewer's yeast (S. cerevisiae) has a protective effect against chemically-induced liver damage in rats. Jun 01, 2009

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Pubmed Data : Clin Nutr. 2009 Jun;28(3):338-45. Epub 2009 Feb 23. PMID: 19233522

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Yeast

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Broccoli sprout extract protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.Sep 20, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID: 26401074

Article Published Date : Sep 20, 2015

Study Type : Animal Study

Additional Links

Substances : Broccoli Sprouts

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer

Additional Keywords : Gene Expression Regulation, Plant Extracts

Problem Substances : Acetaminophen

[+]

Bromelain ameliorates hepatic microcirculation after warm ischemia indicating it may have liver protective effects after injury. May 01, 2007

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Pubmed Data : J Surg Res. 2007 May 1;139(1):88-96. Epub 2007 Feb 8. PMID: 17292418

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Butterbur extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice.Sep 30, 2010

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Pubmed Data : J Med Food. 2010 Oct ;13(5):1216-23. PMID: 20828319

Article Published Date : Sep 30, 2010

Study Type : Animal Study

Click here to read the entire abstract

Pubmed Data : Biotech Histochem. 2016 Jan 21:1-12. Epub 2016 Jan 21. PMID: 26796199

Article Published Date : Jan 20, 2016

Study Type : Animal Study

Additional Links

Substances : Turmeric

Diseases : Cadmium Poisoning , Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Hepatoprotective

[+]

Caffeic acid phenethyl ester should be considered in the prevention of oxidative stress in diabetic liver.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1421438. Epub 2018 May 2. PMID: 29854073

[+]

Celosia cristata extract prevented oxidative stress-induced liver injury by enhancing hepatocyte antioxidant abilities.Jan 31, 2015

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Pubmed Data : Food Chem. 2015 Feb 1 ;168:572-9. Epub 2014 Jul 31. PMID: 25172750

Chlorella has hepatoprotective properties against tetrachloride-induced oxidative damage in rats.Sep 01, 2009

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Pubmed Data : In Vivo. 2009 Sep-Oct;23(5):747-54. PMID: 19779110

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Cissus quadrangularis protects gainst isoniazid-induced liver damage in rats.Dec 01, 2010

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Pubmed Data : Indian J Pharmacol. 2010 Dec;42(6):397-400. PMID: 21189914

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Cissus quadrangularis

Diseases : Chemically-Induced Liver Damage, Drug-Induced Toxicity , Tuberculosis Drug Induced Toxicity

Pharmacological Actions : Hepatoprotective

[+]

Citrus maxima peel powder produced significant hepatoprotective action in carbon tetrachloride administered rats.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2018 Jun 25 ;18(1):195. Epub 2018 Jun 25. PMID: 29940935

Article Published Date : Jun 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Res Pharm Sci. 2016 Mar-Apr;11(2):120-9. PMID: 27168751

Pubmed Data : Basic Clin Pharmacol Toxicol. 2020 May 25. Epub 2020 May 25. PMID: 32452080

Article Published Date : May 24, 2020

Study Type : Animal Study

Additional Links

Substances : Cucurbitacin B

Diseases : Liver Damage: Drug-Induced, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Transforming growth factor beta (TGF-β) inhibitor

Problem Substances :

Liver Damage jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

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The Following are Sub-Topics of Liver Damage

View the Evidence: 1080 Abstracts with Liver Damage Research

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Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

The use of statins for LDL suppression is associated with increased risk for cancer.Jul 31, 2007

Acetylcysteine for the treatment of suspected remdesivir-associated acute liver Failure in COVID-19.Oct 01, 2020

Atorvastatin-induced acute pancreatitis has been reported.Jan 01, 2011

Autoimmune hepatitis associated with atorvastatin use has been reported.Aug 01, 2003

Bisphenol A was detected above the detection limit in all samples in individuals affected by non-alcoholic fatty liver disease.Jun 04, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Exposure of children to even low doses of BPA may adversely affect later liver function.Nov 16, 2017

Fermented turmeric powder is well-tolerated and effective in subjects with elevated alanine transaminase levels.Dec 31, 2012

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.Aug 12, 2012

Fluvastatin has been linked to adverse hepatic reactions.Jan 01, 2006

Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.Feb 28, 2019

Isoniazid has been associated with grade 3 or 4 liver failure in 1.4%-5.2% of patients being treated for latent tuberculosis infection.Dec 15, 2009

Isoniazid treatment in latent tuberculosis infection may be associated with moderate-to-severe liver damage without symptoms. Jul 01, 2005

Liver failure and damage are rare but severe unintended consequences of statin drug use.Aug 31, 2011

More than half of patients who present at the hospital with acetaminophen-induced liver damage or liver failure have undetectable levels of acetaminophen.Feb 04, 2019

NAC has a therapeutic effect on hepatotoxicity in children being treated with chemotherapeutic agents.Mar 31, 2020

NAC should be considered in management of anti-tuberculosis drug induced liver injury.Aug 25, 2020

Perfluorooctanoic acid has hepatotoxic effects.Jul 31, 2016

Phyllanthus Urinaria is useful in preventing or delaying the development of HBV-associated cirrhosis to hepatocellular carcinoma.Mar 24, 2013

Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients.Feb 29, 2020

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients. Jan 01, 1992

Severe, even fatal liver injuries have resulted as a consequence of isoniazid treatment in individuals with latent tuberculosis.Mar 05, 2010

Silibinin could be beneficial in preventing drug-induced liver injury in tuberculosis treatments. Dec 31, 2014

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

There is evidence that aflatoxin exposure plays a role in the pathogenesis of liver cancer in the US population. Jan 01, 1999

Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess.Feb 28, 2018

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.Jan 01, 2010

Zinc and vitamin C oral supplementation for 1 month had an ameliorative effect on the hepatotoxicity of Aflatoxin B1 in wheat miller workers.Jun 12, 2019

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.Aug 11, 2019

Curcumin could modulate hepatocyte epithelial-mesenchymal transition implicated in treatment of liver fibrosis.Aug 23, 2015

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

A case of hepatitis caused by simvastatin has been reported. Jan 01, 1991

A case report of fluoxetine-induced Stevens-Johnson syndrome and liver injury.Jan 31, 2019

Acute cholestatic hepatitis associated with atorvastatin use has been reported. Jan 01, 2006

Acute cholestatic hepatitis associated with pravastatin has been reported. May 01, 1999

Acute cholestatic hepatitis induced by cerivastatin has been reported. May 18, 2002

Acute cholestatic hepatitis induced by fenofibrate has been reported.Oct 01, 2009

Acute exposure to CS tear gas has been reported to cause several health problems in an individual.Dec 26, 1981

Acute hepatitis induced by lovastatin has been reported. Sep 01, 1994

After taking 30 mg artichoke leaf extract tea 3 times a day, patients bilirubin levels significantly declined at the end of the first week and all liver function tests were normalized within 2 months. Dec 31, 2013

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. Jul 01, 2008

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.Aug 09, 1999

Cholestatic jaundice during lovastatin medication has been reported. May 10, 1991

Cholestatic jaundice induced by atorvastatin has been observed. Jul 01, 2009

Hepatitis associated with treatment with lovastatin has been reported. Mar 01, 1998

Liver fibrosis has been attributed to lipid lowering medications.Sep 01, 2001

Lovastatin monotherapy has been reported to have been a cause of rhabdomyolysis, acute renal failure and hepatopathy.Jul 01, 1997

Mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl has been reported. Oct 01, 2007

N-acetylcysteine in the management of acute liver failure from sickle cell hepatic crisis.Jul 31, 2019

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

Reversible acute hepatitis induced by rosuvastatin has been reported.Jul 01, 2008

Rosuvastatin-associated hepatitis with autoimmune features has been reported. May 01, 2005

Simvastatin has been reported to cause cholestatic hepatitis. Apr 01, 1991

Simvastatin has been reported to cause liver lesions.Apr 13, 1996

Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation has been reported. Sep 01, 2008

Ameliorative effect of kefir against γ-irradiation induced liver injury in male rats: impact on oxidative stress and inflammation.Jun 24, 2020

Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity.Jul 25, 2020

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet.Dec 31, 2019

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect.Sep 15, 2020

Purple grape juices prevent pentylenetetrazol-induced oxidative damage in the liver and serum of Wistar rats.Jan 31, 2013

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage.Apr 29, 2020

"Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury."Oct 01, 2012

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."Oct 01, 2006

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced liver damage in mice.Nov 01, 2011

Liver Damage

View the Evidence:
1080 Abstracts with Liver Damage Research