Myocardial Fibrosis

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45 Substances Researched for Myocardial Fibrosis
NameACCKFocus
Puerarin615Locked
Modified Citrus Pectin 212Locked
Coenzyme Q10110Locked
Selenium110Locked
Curcumin59Locked
Astragaloside36Locked
Tanshinone IIA46Locked
Astaxanthin15Locked
Cinnamaldehyde15Locked
Ginsenosides35Locked
Mangiferin24Locked
Rosmarinic acid24Locked
Piperine23Locked
Piperlongumine 23Locked
Asiatic Acid12Locked
Berberine12Locked
Chlorogenic Acid12Locked
Crocin12Locked
EGCG (Epigallocatechin gallate)12Locked
Emodin12Locked
Fisetin12Locked
Flavonoids12Locked
Fucoidan12Locked
Fucoxanthin 12Locked
Gallic Acid12Locked
Gastrodin12Locked
Ginger12Locked
Licorice12Locked
Lotus 12Locked
Nigella sativa (aka Black Seed)12Locked
Paeoniflorin12Locked
Probiotics12Locked
Procyanidin B2 12Locked
Pterostilbene12Locked
Red Sage12Locked
Rutin12Locked
Safflower12Locked
Thymoquinone12Locked
Ursolic Acid12Locked
Xanthohumol22Locked
Betulinic acid11Locked
Evodiamine11Locked
Gingerol 11Locked
Naringenin 11Locked
Quercetin11Locked
2 Problem Substances Researched for Myocardial Fibrosis
NameACCKFocus
Fructose12Locked
Isoproterenol22Locked
1 Therapeutic Actions Researched for Myocardial Fibrosis
NameACCKFocus
Traditional Chinese Medicine12Locked

View the Evidence:
73 Abstracts with Myocardial Fibrosis Research

[+]

Galectin-3 inhibition with modified citrus pectin in hypertension. Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JACC Basic Transl Sci. 2021 Jan ;6(1):12-21. Epub 2021 Jan 6. PMID: 33532663
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

There was less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10.Dec 07, 2017

Pubmed Data : Biofactors. 2017 Dec 8. Epub 2017 Dec 8. PMID: 29220105
Article Published Date : Dec 07, 2017
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10, Selenium
Diseases : Cardiac Mortality , Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Risk Reduction
[+]

Astaxanthin may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis.Mar 11, 2017

Pubmed Data : Biochim Biophys Acta. 2017 Mar 12. Epub 2017 Mar 12. PMID: 28300638
Article Published Date : Mar 11, 2017
Study Type : Human In Vitro
Additional Links
Substances : Astaxanthin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Cinnamaldehyde may be able to slow down the progression of cardiac fibrosis.Mar 20, 2017

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2017 Mar 21 ;97(11):869-873. PMID: 28355745
Article Published Date : Mar 20, 2017
Study Type : Human In Vitro
Additional Links
Substances : Cinnamaldehyde
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells.Nov 04, 2020

Pubmed Data : Eur J Pharmacol. 2020 Nov 5 ;886:173472. Epub 2020 Aug 27. PMID: 32860809
Article Published Date : Nov 04, 2020
Study Type : Human In Vitro
Additional Links
Substances : Puerarin
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Anti-fibrotic effects of curcumin and some of its analogues in the heart.Sep 10, 2019

Pubmed Data : Heart Fail Rev. 2019 Sep 11. Epub 2019 Sep 11. PMID: 31512150
Article Published Date : Sep 10, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.Nov 14, 2019

Pubmed Data : J Ethnopharmacol. 2019 Nov 15:112404. Epub 2019 Nov 15. PMID: 31739105
Article Published Date : Nov 14, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, MicroRNA modulator
[+]

AstragalosideⅣ was beneficial against cardiac fibrosis.Jun 30, 2017

Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:10-17. Epub 2017 Apr 19. PMID: 28545665
Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Hypoxia, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Bellidifolin ameliorates isoprenaline-induced myocardial fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:644886. Epub 2021 Apr 30. PMID: 33995055
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Berberine might become a new strategy for treating cardiac fibrosis in the future.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(10):12509-16. Epub 2015 Oct 1. PMID: 26722438
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Blackcurrant improves diabetic cardiovascular dysfunction by reducing inflammatory cytokines.Nov 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Nov 22 ;13(11). Epub 2021 Nov 22. PMID: 34836432
Article Published Date : Nov 21, 2021
Study Type : Animal Study
Additional Links
Substances : Black Currant
Diseases : Diabetes Mellitus: Type 2, Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Chlorogenic acid alleviates hyperglycemia-induced cardiac fibrosis.Nov 16, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Nov 17:e2000810. Epub 2020 Nov 17. PMID: 33200558
Article Published Date : Nov 16, 2020
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Cardiomyopathy, Hyperglycemia, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug 7. Epub 2019 Aug 7. PMID: 31392383
Article Published Date : Aug 06, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activation.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2014 Oct ;35(10):1247-56. Epub 2014 Aug 18. PMID: 25132338
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Hypertension, Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Antihypertensive Agents, Cardioprotective
[+]

Curcumin may have therapeutic value in treating aortic stenosis, left ventricular dysfunction and myocardial fibrosis. Mar 01, 2009

Pubmed Data : Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Mar;37(3):262-7. PMID: 19781154
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Aortic Stenosis, Left Ventricular Hypertrophy, Myocardial Fibrosis
[+]

Curcumin protects against myocardial infarction-induced cardiac fibrosis.Dec 31, 2015

Pubmed Data : Drug Des Devel Ther. 2016 ;10:1267-77. Epub 2016 Mar 29. PMID: 27099472
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Cardioprotective, SIRT1 Activator
[+]

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharm Sin B. 2019 Jul ;9(4):724-733. Epub 2019 Apr 22. PMID: 31384533
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):1305-1313. PMID: 34607503
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Epigallocatechin-3-O-gallate attenuated the endoglin expression and myocardial fibrosis in vitro and in vivo.Jun 15, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2016 Jun 16. Epub 2016 Jun 16. PMID: 27306149
Article Published Date : Jun 15, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
[+]

Fisetin alleviates atrial inflammation, remodelling, and vulnerability to atrial fibrillation after myocardial infarction.Nov 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Heart J. 2019 Nov 30 ;60(6):1398-1406. Epub 2019 Oct 31. PMID: 31666455
Article Published Date : Nov 29, 2019
Study Type : Animal Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoidan and fucoxanthin in combination can potentially reduce cardiac hypertrophy, cardiac fibrosis, ROS level,Jan 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2019 Jan 21 ;17(1). Epub 2019 Jan 21. PMID: 30669571
Article Published Date : Jan 20, 2019
Study Type : Animal Study
Additional Links
Substances : Fucoidan, Fucoxanthin
Diseases : Aging: Heart, Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Galangin attenuates isoproterenol-induced inflammation and fibrosis in the cardiac tissue.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:585163. Epub 2020 Nov 30. PMID: 33328989
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
Problem Substances : Isoproterenol
[+]

Gallic acid has therapeutic potential for the treatment of heart failure-induced pulmonary fibrosis.Nov 30, 2017

Pubmed Data : Vascul Pharmacol. 2017 Dec ;99:74-82. Epub 2017 Oct 31. PMID: 29097327
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Gallic Acid
Diseases : Heart Failure, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Gastrodin protects against cardiac hypertrophy and fibrosis.Dec 31, 2011

Pubmed Data : Mol Cell Biochem. 2012 Jan ;359(1-2):9-16. Epub 2011 Jul 16. PMID: 21833534
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Ginger extract protects the heart against inflammation and fibrosis in diabetes.Sep 01, 2020

Pubmed Data : Can J Diabetes. 2020 Sep 2. Epub 2020 Sep 2. PMID: 33162372
Article Published Date : Sep 01, 2020
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Cardiomyopathy, Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts
[+]

Ginsenoside Rg2 alleviates myocardial fibrosis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):106-113. PMID: 33535854
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Ginsenoside Rh2 is suitable to develop as an alternative remedy for cardiac fibrosis.Jun 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jun 26 ;18(7). Epub 2017 Jun 26. PMID: 28672855
Article Published Date : Jun 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes Mellitus: Type 1, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosisSep 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2021 Oct ;24(4). Epub 2021 Jul 30. PMID: 34328199
Article Published Date : Sep 30, 2021
Study Type : Animal Study
Additional Links
Substances : Liquiritigenin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, Transforming growth factor beta (TGF-β) upregulation
[+]

Low-dose PCB126 exposure disrupts cardiac metabolism and causes hypertrophy and fibrosis.Aug 30, 2021

Pubmed Data : Environ Pollut. 2021 Aug 31 ;290:118079. Epub 2021 Aug 31. PMID: 34488161
Article Published Date : Aug 30, 2021
Study Type : Animal Study
Additional Links
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Problem Substances : Polychlorinated biphenyls (PCBs)
Adverse Pharmacological Actions : Cardiotoxic
[+]

Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.Apr 26, 2020

Pubmed Data : Pharmacol Res. 2020 Apr 27 ;157:104845. Epub 2020 Apr 27. PMID: 32353588
Article Published Date : Apr 26, 2020
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Nrf2 activation
[+]

Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2021 Mar 1 ;25(2):131-137. PMID: 33602883
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Aging: Heart, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Modified citrus pectin ameliorates myocardial fibrosis and inflammation.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jun ;126:110071. Epub 2020 Mar 12. PMID: 32172066
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective
[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252
Article Published Date : Sep 19, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Anti-Fibrotic, Cardioprotective, Diabetic Complications, Lotus, Myocardial Fibrosis
[+]

Nrf2 Is a key regulator on puerarin preventing cardiac fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:540. Epub 2018 Jun 6. PMID: 29928229
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Oral administration of probiotics may attenuate cardiomyocyte fibrosis and cardiac hypertrophy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2016 ;13(4):277-85. Epub 2016 Mar 30. PMID: 27076784
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Probiotics
Diseases : High Fat Diet, Myocardial Fibrosis
Pharmacological Actions : Autophagy Up-regulation, Cardioprotective
[+]

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Mar ;111:695-704. Epub 2019 Jan 3. PMID: 30611994
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Cardiac Hypertrophy, Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EBioMedicine. 2017 Apr ;18:179-187. Epub 2017 Mar 14. PMID: 28330809
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis.Jan 31, 2021

Pubmed Data : Phytomedicine. 2021 Feb ;82:153461. Epub 2021 Jan 6. PMID: 33497927
Article Published Date : Jan 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosisAug 14, 2018

Pubmed Data : Eur J Pharmacol. 2018 Aug 15 ;833:545-554. Epub 2018 Jun 18. PMID: 29913124
Article Published Date : Aug 14, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Pterostilbene attenuates fructose-induced myocardial fibrosis. Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:1243215. Epub 2019 Dec 4. PMID: 31871537
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : High Fructose Diet, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Puerarin alleviates lipopolysaccharide-induced myocardial fibrosis.Mar 30, 2020

Pubmed Data : Cardiovasc Toxicol. 2020 Mar 31. Epub 2020 Mar 31. PMID: 32236896
Article Published Date : Mar 30, 2020
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor
[+]

Puerarin could be a potential agent in attenuating myocardial Infarction induced cardiac fibrosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2016 ;8(10):4425-4433. Epub 2016 Oct 15. PMID: 27830026
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic
[+]

Puerarin may provide a new adjuvant for antifibrotic treatment strategies for patients with heart disease.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PPAR Res. 2017 ;2017:2647129. Epub 2017 May 30. PMID: 28638404
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Heart Disease, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Rosmarinic acid can protect against cardiac dysfunction and fibrosis following myocardial infarction.Aug 18, 2016

Pubmed Data : J Agric Food Chem. 2016 Aug 19. Epub 2016 Aug 19. PMID: 27538767
Article Published Date : Aug 18, 2016
Study Type : Animal Study
Additional Links
Substances : Rosmarinic acid
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Rosmarinic acid might be a promising therapeutic agent against cardiac fibrosis.Jan 23, 2018

Pubmed Data : Cell Death Dis. 2018 Jan 24 ;9(2):102. Epub 2018 Jan 24. PMID: 29367637
Article Published Date : Jan 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Rosmarinic acid
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Salvia miltiorrhiza and Carthamus tinctorius extract prevents cardiac fibrosis and dysfunction after myocardial infarction.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:6479136. Epub 2019 May 30. PMID: 31275414
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Red Sage, Safflower
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Tanshinone IIA exerts antifibrotic effects in postinfarct cardiac fibrosis.Apr 30, 2015

Pubmed Data : J Cardiovasc Pharmacol. 2015 May ;65(5):456-64. PMID: 25636075
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Tanshinone IIA protects against subclinical lipopolysaccharide induced cardiac fibrosis.Jun 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jul ;60:59-63. Epub 2018 Apr 25. PMID: 29704740
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

The protective role of liquiritin in high fructose-induced myocardial fibrosis.Nov 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:1337-1349. Epub 2016 Nov 1. PMID: 27810791
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Licorice
Diseases : High Fructose Diet, Inflammation, Insulin Resistance, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, NF-kappaB Inhibitor
[+]

These results provide evidence for the cardioprotective action of grape seed procyanidin B2 against asporin injury.Sep 08, 2019

Pubmed Data : Cell Biol Int. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31498521
Article Published Date : Sep 08, 2019
Study Type : Animal Study
Additional Links
Substances : Procyanidin B2
Diseases : Cardiomyopathy, Myocardial Fibrosis
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

These results suggested that puerarin could prevent isoprenaline-induced myocardial fibrosis.Aug 31, 2012

Pubmed Data : J Nutr Biochem. 2012 Sep ;23(9):1080-5. Epub 2011 Nov 12. PMID: 22079205
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, NF-kappaB Inhibitor
[+]

Thymoquinone prevents myocardial and perivascular fibrosis induced by chronic lipopolysaccharide exposure.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2018 Dec ;21(4):284-293. Epub 2018 Dec 31. PMID: 30652055
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Treatment by Nigella sativa reduced myocardial fibrosis in inflammation-induced fibrosis.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2017 Feb ;12(1):74-81. PMID: 28255317
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Anti-Fibrotic, Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis, Nigella sativa (aka Black Seed)
[+]

Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice.Sep 01, 2015

Pubmed Data : Mol Cell Biochem. 2015 Sep ;407(1-2):263-79. Epub 2015 Jun 16. PMID: 26077659
Article Published Date : Sep 01, 2015
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Fibrosis, Insulin Resistance, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Regenerative
Additional Keywords : Heart Regeneration
Problem Substances : Fructose
[+]

Ursolic acid has an anti-fibrotic effect and attenuates the mitochondrial and lysosomal dysfunction in Isoproterenol-induced myocardial infarction.Apr 11, 2019

Pubmed Data : Hum Exp Toxicol. 2019 Apr 12:960327119842620. Epub 2019 Apr 12. PMID: 30977399
Article Published Date : Apr 11, 2019
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Zhigancao decoction can reverse atrial fibrillation-induced myocardial fibrosis in rabbits.Feb 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Med Res. 2019 Feb ;47(2):884-892. Epub 2019 Jan 11. PMID: 30632430
Article Published Date : Feb 01, 2019
Study Type : Animal Study
Additional Links
Diseases : Myocardial Fibrosis
Therapeutic Actions : Traditional Chinese Medicine
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Bodily Tissue Regeneration
[+]

6-gingerol ameliorates isoproterenol -induced myocardial fibrosis.Jun 30, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Jul ;64(13):e2000003. Epub 2020 Jun 8. PMID: 32438504
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
Problem Substances : Isoproterenol
[+]

Asiatic acid alleviates Ang-II induced cardiac hypertrophy and fibrosis via miR-126/PIK3R2 signaling.Jul 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2021 Jul 13 ;18(1):71. Epub 2021 Jul 13. PMID: 34256802
Article Published Date : Jul 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, MicroRNA modulator
[+]

Betulinic acid may offer therapeutic potential towards the treatment of cardiac fibrosis.Oct 31, 2017

Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):6320-6325. Epub 2017 Aug 22. PMID: 28849070
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Curcumin may be a potential therapeutic agent for the treatment of cardiac fibrosis.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Mar ;11(3):998-1004. Epub 2016 Jan 8. PMID: 26998027
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Evodiamine prevents isoproterenol-induced cardiac fibrosis.May 31, 2017

Pubmed Data : Planta Med. 2017 Jun ;83(9):761-769. Epub 2016 Dec 23. PMID: 28010025
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Evodiamine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Problem Substances : Isoproterenol
[+]

Ginsenoside Rg2 attenuates myocardial fibrosis and improves cardiac function after myocardial infarction.Jul 23, 2020

Pubmed Data : Biosci Biotechnol Biochem. 2020 Jul 24:1-8. Epub 2020 Jul 24. PMID: 32706304
Article Published Date : Jul 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Magnolol inhibits the proliferation and collagen synthesis of cardiac fibroblasts.Apr 15, 2021

Pubmed Data : Bioorg Med Chem Lett. 2021 Apr 16 ;43:128045. Epub 2021 Apr 16. PMID: 33865968
Article Published Date : Apr 15, 2021
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Cardiovascular Diseases, Heart Failure, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Naringenin may become a novel strategy for treating cardiac fibrosis.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Nov ;14(5):4425-4430. Epub 2017 Sep 5. PMID: 29104653
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Naringenin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Piperine can inhibit the transformation of endothelial cells into fibroblasts.Jul 23, 2019

Pubmed Data : Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Jul 24 ;47(7):554-560. PMID: 31365997
Article Published Date : Jul 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Piperine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts.Nov 30, 2018

Pubmed Data : J Cell Biochem. 2018 Dec ;119(12):10358-10364. Epub 2018 Aug 26. PMID: 30145839
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Quercetin inhibition of myocardial fibrosis through regulating MAPK signaling pathway via ROS.Apr 30, 2019

Pubmed Data : Pak J Pharm Sci. 2019 May ;32(3 Special):1355-1359. PMID: 31551215
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3.Jun 06, 2021

Pubmed Data : Cell Cycle. 2021 Jun 7:1-17. Epub 2021 Jun 7. PMID: 34097559
Article Published Date : Jun 06, 2021
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, MicroRNA modulator
[+]

Tanshinone IIA could be beneficial in the treating diabetic-related cardiac fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;51(5):2250-2261. Epub 2018 Dec 7. PMID: 30537733
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation
[+]

Tanshinone IIA protects against cardiac fibrosis through inhibition of β-tubulin expression.Oct 31, 2018

Pubmed Data : J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6):1451-1455. PMID: 30574749
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis.Oct 26, 2020

Pubmed Data : Eur J Pharmacol. 2020 Oct 27:173690. Epub 2020 Oct 27. PMID: 33127362
Article Published Date : Oct 26, 2020
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Xanthohumol inhibits TGF-β1-induced cardiac fibroblasts activation via mediating PTEN/Akt/mTOR signalling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:5431-5439. Epub 2020 Dec 7. PMID: 33324040
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective

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