Myocardial Fibrosis

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6 Substances Researched for Myocardial Fibrosis
NameACCKFocus
Curcumin47Locked
Berberine12Locked
EGCG (Epigallocatechin gallate)12Locked
Probiotics12Locked
Puerarin12Locked
Rosmarinic acid12Locked

View the Evidence:
60 Abstracts with Myocardial Fibrosis Research

[+]

There was less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10.Dec 07, 2017

Pubmed Data : Biofactors. 2017 Dec 8. Epub 2017 Dec 8. PMID: 29220105
Article Published Date : Dec 07, 2017
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10, Selenium
Diseases : Cardiac Mortality , Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Risk Reduction
[+]

Astaxanthin may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis.Mar 11, 2017

Pubmed Data : Biochim Biophys Acta. 2017 Mar 12. Epub 2017 Mar 12. PMID: 28300638
Article Published Date : Mar 11, 2017
Study Type : Human In Vitro
Additional Links
Substances : Astaxanthin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Cinnamaldehyde may be able to slow down the progression of cardiac fibrosis.Mar 20, 2017

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2017 Mar 21 ;97(11):869-873. PMID: 28355745
Article Published Date : Mar 20, 2017
Study Type : Human In Vitro
Additional Links
Substances : Cinnamaldehyde
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells.Nov 04, 2020

Pubmed Data : Eur J Pharmacol. 2020 Nov 5 ;886:173472. Epub 2020 Aug 27. PMID: 32860809
Article Published Date : Nov 04, 2020
Study Type : Human In Vitro
Additional Links
Substances : Puerarin
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Anti-fibrotic effects of curcumin and some of its analogues in the heart.Sep 10, 2019

Pubmed Data : Heart Fail Rev. 2019 Sep 11. Epub 2019 Sep 11. PMID: 31512150
Article Published Date : Sep 10, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.Nov 14, 2019

Pubmed Data : J Ethnopharmacol. 2019 Nov 15:112404. Epub 2019 Nov 15. PMID: 31739105
Article Published Date : Nov 14, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, MicroRNA modulator
[+]

AstragalosideⅣ was beneficial against cardiac fibrosis.Jun 30, 2017

Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:10-17. Epub 2017 Apr 19. PMID: 28545665
Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Hypoxia, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Berberine might become a new strategy for treating cardiac fibrosis in the future.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(10):12509-16. Epub 2015 Oct 1. PMID: 26722438
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Chlorogenic acid alleviates hyperglycemia-induced cardiac fibrosis.Nov 16, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Nov 17:e2000810. Epub 2020 Nov 17. PMID: 33200558
Article Published Date : Nov 16, 2020
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Cardiomyopathy, Hyperglycemia, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug 7. Epub 2019 Aug 7. PMID: 31392383
Article Published Date : Aug 06, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activation.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2014 Oct ;35(10):1247-56. Epub 2014 Aug 18. PMID: 25132338
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Hypertension, Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Antihypertensive Agents, Cardioprotective
[+]

Curcumin may have therapeutic value in treating aortic stenosis, left ventricular dysfunction and myocardial fibrosis. Mar 01, 2009

Pubmed Data : Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Mar;37(3):262-7. PMID: 19781154
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Aortic Stenosis, Left Ventricular Hypertrophy, Myocardial Fibrosis
[+]

Curcumin protects against myocardial infarction-induced cardiac fibrosis.Dec 31, 2015

Pubmed Data : Drug Des Devel Ther. 2016 ;10:1267-77. Epub 2016 Mar 29. PMID: 27099472
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Cardioprotective, SIRT1 Activator
[+]

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharm Sin B. 2019 Jul ;9(4):724-733. Epub 2019 Apr 22. PMID: 31384533
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Epigallocatechin-3-O-gallate attenuated the endoglin expression and myocardial fibrosis in vitro and in vivo.Jun 15, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2016 Jun 16. Epub 2016 Jun 16. PMID: 27306149
Article Published Date : Jun 15, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
[+]

Fisetin alleviates atrial inflammation, remodelling, and vulnerability to atrial fibrillation after myocardial infarction.Nov 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Heart J. 2019 Nov 30 ;60(6):1398-1406. Epub 2019 Oct 31. PMID: 31666455
Article Published Date : Nov 29, 2019
Study Type : Animal Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoidan and fucoxanthin in combination can potentially reduce cardiac hypertrophy, cardiac fibrosis, ROS level,Jan 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2019 Jan 21 ;17(1). Epub 2019 Jan 21. PMID: 30669571
Article Published Date : Jan 20, 2019
Study Type : Animal Study
Additional Links
Substances : Fucoidan, Fucoxanthin
Diseases : Aging: Heart, Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Gallic acid has therapeutic potential for the treatment of heart failure-induced pulmonary fibrosis.Nov 30, 2017

Pubmed Data : Vascul Pharmacol. 2017 Dec ;99:74-82. Epub 2017 Oct 31. PMID: 29097327
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Gallic Acid
Diseases : Heart Failure, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Gastrodin protects against cardiac hypertrophy and fibrosis.Dec 31, 2011

Pubmed Data : Mol Cell Biochem. 2012 Jan ;359(1-2):9-16. Epub 2011 Jul 16. PMID: 21833534
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Ginger extract protects the heart against inflammation and fibrosis in diabetes.Sep 01, 2020

Pubmed Data : Can J Diabetes. 2020 Sep 2. Epub 2020 Sep 2. PMID: 33162372
Article Published Date : Sep 01, 2020
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Cardiomyopathy, Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts
[+]

Ginsenoside Rh2 is suitable to develop as an alternative remedy for cardiac fibrosis.Jun 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jun 26 ;18(7). Epub 2017 Jun 26. PMID: 28672855
Article Published Date : Jun 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes Mellitus: Type 1, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.Apr 26, 2020

Pubmed Data : Pharmacol Res. 2020 Apr 27 ;157:104845. Epub 2020 Apr 27. PMID: 32353588
Article Published Date : Apr 26, 2020
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Nrf2 activation
[+]

Modified citrus pectin ameliorates myocardial fibrosis and inflammation.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jun ;126:110071. Epub 2020 Mar 12. PMID: 32172066
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective
[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252
Article Published Date : Sep 19, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Anti-Fibrotic, Cardioprotective, Diabetic Complications, Lotus, Myocardial Fibrosis
[+]

Nrf2 Is a key regulator on puerarin preventing cardiac fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:540. Epub 2018 Jun 6. PMID: 29928229
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Oral administration of probiotics may attenuate cardiomyocyte fibrosis and cardiac hypertrophy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2016 ;13(4):277-85. Epub 2016 Mar 30. PMID: 27076784
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Probiotics
Diseases : High Fat Diet, Myocardial Fibrosis
Pharmacological Actions : Autophagy Up-regulation, Cardioprotective
[+]

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Mar ;111:695-704. Epub 2019 Jan 3. PMID: 30611994
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Cardiac Hypertrophy, Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EBioMedicine. 2017 Apr ;18:179-187. Epub 2017 Mar 14. PMID: 28330809
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosisAug 14, 2018

Pubmed Data : Eur J Pharmacol. 2018 Aug 15 ;833:545-554. Epub 2018 Jun 18. PMID: 29913124
Article Published Date : Aug 14, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Pterostilbene attenuates fructose-induced myocardial fibrosis. Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:1243215. Epub 2019 Dec 4. PMID: 31871537
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : High Fructose Diet, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Puerarin alleviates lipopolysaccharide-induced myocardial fibrosis.Mar 30, 2020

Pubmed Data : Cardiovasc Toxicol. 2020 Mar 31. Epub 2020 Mar 31. PMID: 32236896
Article Published Date : Mar 30, 2020
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor
[+]

Puerarin could be a potential agent in attenuating myocardial Infarction induced cardiac fibrosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2016 ;8(10):4425-4433. Epub 2016 Oct 15. PMID: 27830026
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic
[+]

Puerarin may provide a new adjuvant for antifibrotic treatment strategies for patients with heart disease.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PPAR Res. 2017 ;2017:2647129. Epub 2017 May 30. PMID: 28638404
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Heart Disease, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Rosmarinic acid can protect against cardiac dysfunction and fibrosis following myocardial infarction.Aug 18, 2016

Pubmed Data : J Agric Food Chem. 2016 Aug 19. Epub 2016 Aug 19. PMID: 27538767
Article Published Date : Aug 18, 2016
Study Type : Animal Study
Additional Links
Substances : Rosmarinic acid
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Rosmarinic acid might be a promising therapeutic agent against cardiac fibrosis.Jan 23, 2018

Pubmed Data : Cell Death Dis. 2018 Jan 24 ;9(2):102. Epub 2018 Jan 24. PMID: 29367637
Article Published Date : Jan 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Rosmarinic acid
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Salvia miltiorrhiza and Carthamus tinctorius extract prevents cardiac fibrosis and dysfunction after myocardial infarction.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:6479136. Epub 2019 May 30. PMID: 31275414
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Red Sage, Safflower
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Tanshinone IIA exerts antifibrotic effects in postinfarct cardiac fibrosis.Apr 30, 2015

Pubmed Data : J Cardiovasc Pharmacol. 2015 May ;65(5):456-64. PMID: 25636075
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Tanshinone IIA protects against subclinical lipopolysaccharide induced cardiac fibrosis.Jun 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jul ;60:59-63. Epub 2018 Apr 25. PMID: 29704740
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

The protective role of liquiritin in high fructose-induced myocardial fibrosis.Nov 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:1337-1349. Epub 2016 Nov 1. PMID: 27810791
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Licorice
Diseases : High Fructose Diet, Inflammation, Insulin Resistance, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, NF-kappaB Inhibitor
[+]

These results provide evidence for the cardioprotective action of grape seed procyanidin B2 against asporin injury.Sep 08, 2019

Pubmed Data : Cell Biol Int. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31498521
Article Published Date : Sep 08, 2019
Study Type : Animal Study
Additional Links
Substances : Procyanidin B2
Diseases : Cardiomyopathy, Myocardial Fibrosis
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

These results suggested that puerarin could prevent isoprenaline-induced myocardial fibrosis.Aug 31, 2012

Pubmed Data : J Nutr Biochem. 2012 Sep ;23(9):1080-5. Epub 2011 Nov 12. PMID: 22079205
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, NF-kappaB Inhibitor
[+]

Thymoquinone prevents myocardial and perivascular fibrosis induced by chronic lipopolysaccharide exposure.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2018 Dec ;21(4):284-293. Epub 2018 Dec 31. PMID: 30652055
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Treatment by Nigella sativa reduced myocardial fibrosis in inflammation-induced fibrosis.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2017 Feb ;12(1):74-81. PMID: 28255317
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Anti-Fibrotic, Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis, Nigella sativa (aka Black Seed)
[+]

Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice.Sep 01, 2015

Pubmed Data : Mol Cell Biochem. 2015 Sep ;407(1-2):263-79. Epub 2015 Jun 16. PMID: 26077659
Article Published Date : Sep 01, 2015
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Fibrosis, Insulin Resistance, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Regenerative
Additional Keywords : Heart Regeneration
Problem Substances : Fructose
[+]

Ursolic acid has an anti-fibrotic effect and attenuates the mitochondrial and lysosomal dysfunction in Isoproterenol-induced myocardial infarction.Apr 11, 2019

Pubmed Data : Hum Exp Toxicol. 2019 Apr 12:960327119842620. Epub 2019 Apr 12. PMID: 30977399
Article Published Date : Apr 11, 2019
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Zhigancao decoction can reverse atrial fibrillation-induced myocardial fibrosis in rabbits.Feb 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Med Res. 2019 Feb ;47(2):884-892. Epub 2019 Jan 11. PMID: 30632430
Article Published Date : Feb 01, 2019
Study Type : Animal Study
Additional Links
Diseases : Myocardial Fibrosis
Therapeutic Actions : Traditional Chinese Medicine
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Bodily Tissue Regeneration
[+]

6-gingerol ameliorates isoproterenol -induced myocardial fibrosis.Jun 30, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Jul ;64(13):e2000003. Epub 2020 Jun 8. PMID: 32438504
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
Problem Substances : Isoproterenol
[+]

Betulinic acid may offer therapeutic potential towards the treatment of cardiac fibrosis.Oct 31, 2017

Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):6320-6325. Epub 2017 Aug 22. PMID: 28849070
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Curcumin may be a potential therapeutic agent for the treatment of cardiac fibrosis.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Mar ;11(3):998-1004. Epub 2016 Jan 8. PMID: 26998027
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Evodiamine prevents isoproterenol-induced cardiac fibrosis.May 31, 2017

Pubmed Data : Planta Med. 2017 Jun ;83(9):761-769. Epub 2016 Dec 23. PMID: 28010025
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Evodiamine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Problem Substances : Isoproterenol
[+]

Ginsenoside Rg2 attenuates myocardial fibrosis and improves cardiac function after myocardial infarction.Jul 23, 2020

Pubmed Data : Biosci Biotechnol Biochem. 2020 Jul 24:1-8. Epub 2020 Jul 24. PMID: 32706304
Article Published Date : Jul 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Naringenin may become a novel strategy for treating cardiac fibrosis.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Nov ;14(5):4425-4430. Epub 2017 Sep 5. PMID: 29104653
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Naringenin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Piperine can inhibit the transformation of endothelial cells into fibroblasts.Jul 23, 2019

Pubmed Data : Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Jul 24 ;47(7):554-560. PMID: 31365997
Article Published Date : Jul 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Piperine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts.Nov 30, 2018

Pubmed Data : J Cell Biochem. 2018 Dec ;119(12):10358-10364. Epub 2018 Aug 26. PMID: 30145839
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Quercetin inhibition of myocardial fibrosis through regulating MAPK signaling pathway via ROS.Apr 30, 2019

Pubmed Data : Pak J Pharm Sci. 2019 May ;32(3 Special):1355-1359. PMID: 31551215
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Tanshinone IIA could be beneficial in the treating diabetic-related cardiac fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;51(5):2250-2261. Epub 2018 Dec 7. PMID: 30537733
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation
[+]

Tanshinone IIA protects against cardiac fibrosis through inhibition of β-tubulin expression.Oct 31, 2018

Pubmed Data : J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6):1451-1455. PMID: 30574749
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis.Oct 26, 2020

Pubmed Data : Eur J Pharmacol. 2020 Oct 27:173690. Epub 2020 Oct 27. PMID: 33127362
Article Published Date : Oct 26, 2020
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Xanthohumol inhibits TGF-β1-induced cardiac fibroblasts activation via mediating PTEN/Akt/mTOR signalling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:5431-5439. Epub 2020 Dec 7. PMID: 33324040
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
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Substances : Xanthohumol
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective

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