Neurodegenerative Diseases

Name	AC	CK
Ginkgo biloba	28	216
Curcumin	105	209
Vitamin D	15	207
Huperzine	23	121
Melatonin	27	121
Coenzyme Q10	21	109
Vitamin E	17	108
Vitamin B-12	12	95
Folic Acid	16	93
Resveratrol	52	78
Cannabidiol	28	66
Ginsenosides	39	62
Coconut Oil	11	61
Polyphenols	29	61
Coffee	8	57
Flavonoids	25	56
Vitamin B-6	8	56
B-complex	6	55
Cannabis	16	55
Cannabinoids	28	52
Vegetables: All	6	52
Alpha-Lipoic Acid	12	47
EGCG (Epigallocatechin gallate)	29	44
Lavender: Essential Oil	5	44
Thymoquinone	24	44
Delta-tetrahydrocannabinol (THC)	11	43
Probiotics	10	43
Sage	5	42
Fruit: All	4	41
Mucuna pruriens (aka Velvet Beans)	13	41
Bee Venom	10	38
Catechin	10	37
Saffron	13	37
Polyunsaturated Fatty Acids (PUFAs)	6	36
Bacopa	15	35
Anthocyanins	12	34
EPA (Eicosapentaenoic Acid)	5	34
Olive Oil	8	32
SAMe (S-adenosylmethionine)	4	32
Puerarin	16	31
Rosemary	7	30
Palmitoylethanolamide	11	29
Green Tea	12	28
Nobiletin	10	28
Selenium	7	28
Vitamin C	17	28
Berberine	17	27
Omega-3 Fatty Acids	6	26
Astaxanthin	17	24
Holy Basil	3	24
Thiamine (B-1)	4	24
Caffeine	5	23
Carotenoids	3	23
Pomegranate	12	23
Turmeric	12	23
Vitamin B12: methylcobalamin	5	23
Gastrodin	13	22
Lemon Balm	3	22
Lion's Mane (Hericium Erinaceus)	8	22
NAC (N-acetyl-L-cysteine)	3	22
Quercetin	13	22
Tanshinone IIA	13	22
Genistein	12	21
Lutein	2	21
Sulforaphane	12	21
Carnitine, Acetyl-L-	2	20
Papaya: Fermented	1	20
Piperidines	1	20
St. John's Wort	1	20
Fucoidan	11	19
Rose	5	19
Creatine	4	18
Stilbenes	10	18
Baicalein	9	17
Crocin	7	17
Fisetin	8	17
Red Wine Extract	4	17
Ashwagandha	10	16
DHA (Docosahexaenoic Acid)	9	16
Ginger	9	16
Gotu Kola	10	16
Nigella sativa (aka Black Seed)	9	16
Antioxidant formulas	4	15
Estradiol (E(2))	8	15
Naringenin	10	15
Progesterone	4	15
Rosmarinic acid	6	15
Walnut	8	15
Apigenin	6	14
Apples	3	14
Bamboo	5	14
Carnosic Acid	6	14
Coconut	4	14
Glutathione	5	14
Luteolin	7	14
Prebiotics	3	14
Testosterone	3	14
Zinc	3	14
Asiatic Acid	8	13
Ginseng (Korean)	7	13
Honokiol	7	13
Medium Chain Triglycerides	2	13
Phloretin	4	13
Reishi Mushroom	6	13
Spirulina	6	13
Amla Fruit	4	12
Cinnamon	8	12
Culinary Herbs and Spices	2	12
Fish Oil	2	12
Folate	2	12
Green Coffee Bean	2	12
Lavender	2	12
Lychee	5	12
Phosphatidylserine	2	12
Piperine	7	12
Royal Jelly	8	12
Berries: All	2	11
Citrus Peel	4	11
Copper	2	11
6-Shogaol	6	10
Black Currant	1	10
Cholesterol	1	10
Curry Spice	1	10
Eicosapentaenoic acid (EPA)	2	10
Ellagic Acid	6	10
GlyceroPhosphoCholine (alpha-GPC)	1	10
Hesperidin	6	10
Lycopene	5	10
Magnesium	6	10
Melissa (Lemonbalm)	1	10
Monounsaturated fatty acids	1	10
Nuts	1	10
Oleuropein	8	10
Paeoniflorin	6	10
Rosemary: Essential Oil	1	10
Rutin	5	10
Sea Cucumber	1	10
Silibinin	3	10
Silica	1	10
Silica: Orthosilicic acid	1	10
Superoxide dismutase	1	10
Theanine	6	10
Vitamin B-3 (Niacin)	1	10
Whey	1	10
Black Pepper	5	9
Blueberry	6	9
Goji	6	9
Myricetin	5	9
Passion Flower	4	9
Persimmon	6	9
Syrian rue	5	9
Tangeretin	4	9
Chokeberry	4	8
Chrysin	4	8
Ferulic acid	4	8
Ginseng	4	8
Glycoaminoglycans	4	8
Isoflavones	2	8
Rice Bran	3	8
Spikenard	4	8
Thymol	4	8
Astragaloside	6	7
Brown Rice: Pre-Germinated	2	7
Chlorogenic Acid	4	7
Hydrogen Water	2	7
Insulin-like Growth Factor (IGF-1)	4	7
Moringa oleifera	4	7
Rosemaric Acid	4	7
Vanillin	3	7
Chinese Skullcap	4	6
Demethoxycurcumin	4	6
Fenugreek	3	6
Fermented Foods and Beverages	4	6
Grape Seed Extract	3	6
Gynostemma	4	6
Hydroxytyrosol	5	6
Olive	3	6
Plum	2	6
Pomegranate Peel	2	6
S-Adenosylmethionine (SAMe)	4	6
Sesamin	3	6
Sesamol	3	6
Ursolic Acid	3	6
Wine	2	6
Acetyl-l-carnitine	3	5
Amurensin G	1	5
Beta-Caryophyllene	3	5
Bromelain	1	5
Caprylic Acid	2	5
Echinacea	3	5
Fucoxanthin	4	5
Geraniol	3	5
Long Pepper	3	5
Lotus	3	5
Mangiferin	3	5
Medicinal Mushrooms	2	5
Oleocanthal	1	5
Panax Notoginseng	3	5
Piperlongumine	3	5
Red Sage	3	5
Strawberry	4	5
Verbascoside	3	5
Avocado	1	4
Barberry	3	4
Bay leaf	1	4
Betulinic acid	2	4
Bifidobacterium Longum	2	4
Black Tea	3	4
Caffeic acid phenethyl ester	2	4
Carvacrol	2	4
Cocoa	3	4
Cordyceps sinensis	2	4
Cysteine (see N-Acetylcysteine)	1	4
Diosgenin	2	4
Dopa bean	2	4
Emodin	1	4
Eugenol	2	4
False Black Pepper	2	4
Ginseng (American)	2	4
Gold (nanoparticles)	2	4
Grape	2	4
Guarana	1	4
Kimchi	2	4
Licorice	3	4
Ligustrazine	2	4
Lupeol	1	4
Mangosteen	3	4
Mulberry	2	4
Mushrooms: All	2	4
Nettle	2	4
Panax Ginseng	2	4
Perilla	3	4
Piceatannol	3	4
Prunella vulgaris	2	4
Punicalagin	4	4
Purslane	2	4
Radish	2	4
Soy	1	4
Soy Protein	1	4
St. Johns Wort	2	4
Tetrahydrocurcumin	1	4
Ume (Japanese apricot)	2	4
Vitexins	3	4
Agaricus Blazei	2	3
Allicin	2	3
Antrodia camphorata	2	3
Arginine	2	3
Ayahuasca	2	3
Bael	2	3
Blackberry	2	3
Butyrate	2	3
Carnosine	2	3
Chaenomeles speciosa	2	3
Citrus naringin	2	3
Coptis chinensis	2	3
Cranberry	2	3
Dandelion	3	3
Garlic	3	3
Garlic: Aged	1	3
Genipin	1	3
Honey	3	3
Hyperforin	2	3
Isothiocyanate	2	3
Kudzu	2	3
Lignans	2	3
Melanin: Bacterial	2	3
Multivitamin	1	3
Nicotinamide adenine dinucleotide (NADH)	2	3
Oleanolic acid	2	3
Riboflavin (Vitamin B-2)	2	3
Safranal	2	3
Schisandra	2	3
Tauroursodeoxycholic acid	2	3
Turmerones	2	3
Zataria multiflora	2	3
18β-Glycyrrhetinic Acid	1	2
5-HTP (5-Hydroxytryptophan)	1	2
Amino Acids: Branched Chain	1	2
Angelica	1	2
Anise	1	2
Apple	1	2
Arctigenin	1	2
Ayurvedic Formulation: Chyawanprash	1	2
Basil	1	2
Beet	1	2
Bifidobacterium Breve	1	2
Bifidobacterium Lactis	1	2
Bilberry	1	2
Bitter Orange	1	2
Caffeic Acid	1	2
Caffeoylquinic Acids	1	2
Cannabinoids: Synthetic	2	2
Capparis spinosa (caper)	1	2
Carnosol	1	2
Cashew	1	2
Celery	1	2
Chaga Mushroom (Inonotus obliquus)	1	2
Cherry: All Varieties	1	2
Chromium	1	2
Coconut Water	1	2
Crocetin	1	2
Cucurbitacin E	1	2
Curcuminoids	2	2
Daidzein	1	2
Date Seeds	1	2
Eicosanoyl-5-hydroxytryptamide (EHT)	1	2
Elderberry	2	2
Epicatechin	1	2
Essential Oils: Unspecified	1	2
Evodia ruteacarpa	1	2
FOS (Fructooligosaccharides)	1	2
Fig	1	2
Frankincense	1	2
Galactooligosaccharides	1	2
Gingerol	1	2
Ginseng (Asian)	1	2
Grapefruit Seed Extract	1	2
Grewia Asiatica	1	2
Hops	1	2
Icariin	1	2
Isoliquiritigenin	2	2
Japanese mugwort	1	2
Jujube	1	2
Kaempferol	1	2
Kava Kava	2	2
Kiwifruit	1	2
Krill	1	2
Lactobacillus Acidophilus	1	2
Lactobacillus fermentum	1	2
Lactobacillus helveticus	1	2
Lauric acid	2	2
Loquat	1	2
Lysine	1	2
Magnolol	1	2
Mango	1	2
Mango leaf	1	2
Marijuana	1	2
Moxibustion	1	2
Myrtle	1	2
Nattokinase	1	2
Niacin	1	2
Noni	1	2
Octacosanol	1	2
Olive leaf extract	1	2
Peony	1	2
Policosanol	1	2
Poria cocos	1	2
Propolis: Bee	1	2
Psyllium	1	2
Pterostilbene	2	2
Pycnogenol (Pine Bark)	1	2
Pyruvate	1	2
Raisins	1	2
Raspberry	2	2
Red Clover	1	2
Red Yeast Rice	1	2
Rhubarb	1	2
Rooibos	1	2
Rose Hips	1	2
Salvia miltiorrhiza	2	2
Satsuma	1	2
Scolopendra subspinipes mutilans	1	2
Seaweed: Brown	1	2
Sesame Seeds	1	2
Sweet Potato: Purple	1	2
Tart Cherry	1	2
Tocotrienol: Delta	1	2
Ubiquinol	1	2
Valerian	1	2
Vitamin A	1	2
Wen Pi Tang	1	2
White Tea	2	2
Wogonin	1	2
Xanthohumol	2	2
Yeast	1	2
Yerba Mate	1	2
beta-Carotene	1	2
phytoestrogens	1	2
Acacia catechu	1	1
Achillea fragrantissima	1	1
Almond	1	1
Asparagus	1	1
Bee Propolis	1	1
Bergamot	1	1
Bisdemethoxycurcumin	1	1
Black Raspberry	1	1
Black Tea Theaflavins	1	1
Boerhaavia diffusa	1	1
Broccoli Sprouts	1	1
Brussel sprouts	1	1
Cannabichromene	1	1
Cannabigerol	1	1
Cardamom	1	1
Carnitine	1	1
Carob	1	1
Carpolobia lutea	1	1
Catechols	1	1
Chickpea	1	1
Chili pepper	1	1
Chrysanthemum Indicum	1	1
Cinnamaldehyde	1	1
Clove	1	1
Codonopsis pilosula	1	1
Coffee: Green/Unroasted	1	1
Colostrum	1	1
Cordyceps Militaris	1	1
Coriandor	1	1
Coriandrum sativum	1	1
Coumestrol	1	1
Cumin	1	1
Cyanidin	1	1
Daisy	1	1
Devils Claw	1	1
Endocannabinoids	1	1
Fiber	1	1
Gallic Acid	1	1
Ginseng (Siberian)	1	1
Glycyrrhiza uralensis	1	1
Grapes	1	1
Guava	1	1
Haritaki (Terminalia chebula)	1	1
Hawthorn	1	1
Hazelnut	1	1
Hemp Seed	1	1
Herbal Therapies (Unspecified in Abstracts)	1	1
Hibiscus sabdariffa	1	1
Indole-3-Carbinol	1	1
Isoquercitrin	1	1
Lingonberry	1	1
Lithium	1	1
Maple Syrup	1	1
Milk Thistle	1	1
Mistletoe	1	1
Neem	1	1
Okra	1	1
Orange: Mandarin	1	1
Papaya	1	1
Patchouli	1	1
Phytate	1	1
Procyanidin B2	1	1
Propolis: Brazillian	1	1
Red Pepper	1	1
Rehmannia	1	1
Rice: Black	1	1
Sembung Leaf	1	1
Spinach	1	1
Sweet Cherry	1	1
Tannic Acid	1	1
Tea	1	1
Theaflavins	1	1
Theophylline	1	1
Thyme	1	1
Tibetan Herbal Formula: Padma 28	1	1
Toona sinensis	1	1
Trigonelline	1	1
Triptolide	1	1
Vitamin B6	1	1
Water: Deep Sea	1	1
White Mulberry	1	1
Xanthones	1	1
Yellow Sweet Clover (Melilotus officinalis)	1	1
neohesperidin	1	1
Muira Puama	1	0

Name	AC	CK
Donepezil (trade name Aricept)	7	100
Memantine	5	84
Pesticides	11	69
Aluminum	30	59
Cholinesterase Inhibitor Drugs	4	56
Statin Drugs	7	55
Lead	9	54
Antidepressants	1	40
Antipsychotic Drugs	3	40
Aluminum Chloride	13	32
Benzodiazepines	2	30
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	5	26
Tobacco	2	20
Glyphosate	5	16
Mercury	3	16
Rotenone	9	16
Rivastigmine	2	13
Monosodium Glutamate (MSG)	2	12
Bisphenol A	2	11
Agricultural Chemicals	1	10
Artificially Sweetened Beverages	1	10
Calcium Supplements	1	10
Dental Amalgams	1	10
Hydrogenated Oil	1	10
L-glutamic Acid	1	10
Nicotine	1	10
Organochlorine pesticides	1	10
Persistent organic pollutants (POPs)	1	10
Radon	1	10
Zolpidem (trade name Ambien)	1	10
Lyme's Disease (Borrelia burgdorferi)	3	9
Paraquat	3	7
Sodium Fluoride	4	7
Thimerosal	3	7
Chlorpyrifos	4	5
Herbicides	1	5
Acrylamide	2	4
Aluminum oxide	1	4
Cadmium	3	4
Fluoride	2	4
Formaldehyde	2	4
Glyphosate formulations	1	4
Roundup (herbicide)	1	4
Atorvastatin	2	3
Eptastigmine	1	3
Galantamine	1	3
Antibiotics	1	2
Arsenite	1	2
Aspartame	1	2
Canola Oil	1	2
Cell Phone Exposure	1	2
Electronic Cigarettes	1	2
Flame Retardants	1	2
Gluten	2	2
Heavy Metals	1	2
Lovastatin	1	2
Organophosphates	1	2
Tamoxifen	1	2
Toluene	1	2
Tricresyl phosphates (TCPs)	1	2
Acetaminophen	1	1
Aluminium Cans	1	1
Cholesterol Lowering Drugs	1	1
Cobalt	1	1
Cow Milk	1	1
Dimethoate	1	1
Excitotoxins	1	1
Paracetamol	1	1
Proton-Pump Inhibitors	1	1
Simvastatin	1	1
Stannous chloride	1	1
Sugary soda	1	1
Vaccine Adjuvants	1	1
Zineb	1	1

Name	AC	CK
Exercise	58	312
Acupuncture	12	97
Exercise: Aerobic	8	93
Music	10	85
Dietary Modification: Mediterranean Diet	5	41
Qigong	3	40
Tai Chi	3	40
Meditation	5	36
Electroacupuncture	9	34
Aromatherapy	4	32
Ai-Chi Aquatic Exercise	3	30
Dancing	3	30
Massage/Therapeutic Touch	3	30
Light-Emitting Diodes (LEDs) Therapy	2	26
Dietary Modification: Low Carbohydrate/Ketogenic	9	24
Drumming	2	20
Mindfullness Training	1	20
Stem Cell Related Therapy	4	15
Laser Treatment: Low-Level	3	14
Horticultural Therapy (Gardening)	2	11
Integrative Medicine	2	11
Acupressure	1	10
Acupuncture: auricular	1	10
Animal Therapy	1	10
Aromatherapy Massage	1	10
Exercise: Cycling	1	10
Exercise: Endurance	1	10
Laughter/Humor	1	10
Loving	1	10
Mediterranean diet	1	10
Relaxation Therapy	1	10
Spiritual/Religious Practice	1	10
Sunlight exposure	1	10
Therapeutic Breathing	1	10
Fasting/Caloric Restriction	6	9
Hyperbaric Treatment	2	4
Mind-Body Therapies	1	4
Yoga	2	4
Melodic Intonation Therapy	2	3
Intermittent Hypoxia (low oxygen)	1	2
Light Therapy	1	2
Aquatic therapy	1	1
Craniosacral Therapy	1	1
Dietary Modification: High-Fat/Low-Carbohydrate	1	1

Name	AC	CK
Electromagnetic Fields	2	22
Overdiagnosis	2	20
Shift Work	1	20
Vaccination: All	4	15
Low Dose Ionizing Radiation	1	10
Electromagnetic Radiation: 2.4 GHz	2	4
Wi-Fi Radiation	2	4
Mobile Phone Radiation	2	3
Air Travel	1	2
Nanotechnology	1	2
Western Diet	1	2

Problem Substances : Benzodiazepines

[+]

Acupuncture may be effective in improving cognitive function in vascular dementia animal models.Nov 12, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Therapie. 2010 May-Jun;65(3):255-9. Epub 2010 Aug 11. PMID: 20699079

Article Published Date : May 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Alzheimer's Disease, Bradycardia, Epileptic Seizures

Problem Substances : Donepezil (trade name Aricept), Memantine

[+]

Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neuroimage. 2018 02 1 ;166:230-238. Epub 2017 Nov 4. PMID: 29113943

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Alzheimers Dis. 2015 ;43(2):605-11. PMID: 25352453

Article Published Date : Dec 31, 2014

Study Type : Meta Analysis

Additional Links

Substances : Ginkgo biloba

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction, Dementia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Music could be a powerful treatment strategy in dementia.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Alzheimers Dis Rep. 2018 Feb 2 ;2(1):1-26. Epub 2018 Feb 2. PMID: 30480245

Article Published Date : Feb 01, 2018

Study Type : Meta Analysis, Review

Additional Links

Diseases : All-Cause Mortality, Dementia

Additional Keywords : Increased Risk

Problem Substances : Antipsychotic Drugs

[+]

Reduced exposure to sunlight were significantly associated with an increased risk of Parkinson's disease.Jan 22, 2019

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Pubmed Data : Med Sci Monit. 2019 Jan 23 ;25:666-674. Epub 2019 Jan 23. PMID: 30672512

Article Published Date : Jan 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharm Health Care Sci. 2015 ;1:14. Epub 2015 Apr 10. PMID: 26819725

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Pubmed Data : J Psychopharmacol. 2020 Jan 7:269881119895536. Epub 2020 Jan 7. PMID: 31909680

Pubmed Data : Hum Psychopharmacol. 2014 Jul ;29(4):351-9. PMID: 25163440

Article Published Date : Jun 30, 2014

Study Type : Human Study

Additional Links

Substances : Saffron

Diseases : Alzheimer's Disease

Additional Keywords : Natural Substances Versus Drugs, Phytotherapy, Plant Extracts

Problem Substances : Memantine

[+]

Aerobic exercise in early Alzheimer’s disease is associated with benefits in functional ability.Dec 31, 2016

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Pubmed Data : Clin Ther. 2003 Jan;25(1):178-93. PMID: 12637119

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : GlyceroPhosphoCholine (alpha-GPC)

Diseases : Alzheimer's Disease

[+]

Click here to read the entire abstract

Pubmed Data : Am J Alzheimers Dis Other Demen. 2003 Nov-Dec;18(6):353-8. PMID: 14682084

Article Published Date : Nov 01, 2003

Study Type : Human Study

Additional Links

Diseases : Dementia

Therapeutic Actions : Animal Therapy

[+]

Antioxidant beverages could be used as a natural complementary therapy to alleviate or decrease oxidative stress in Alzheimer’s disease.Aug 22, 2015

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Pubmed Data : Eur J Nutr. 2015 Aug 23. Epub 2015 Aug 23. PMID: 26298312

Article Published Date : Aug 22, 2015

Study Type : Human Study

Additional Links

Substances : Apples, Green Tea

Diseases : Alzheimer's Disease, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Click here to read the entire abstract

Pubmed Data : J Alzheimers Dis. 2019 Dec 2. Epub 2019 Dec 2. PMID: 31815694

Article Published Date : Dec 01, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction, Vitamin D Deficiency

Pharmacological Actions : Neuroprotective Agents

[+]

Cocoa procyanidins attenuate lipid peroxidation associated neuronal cell death in a manner relevant to Alzheimer's disease.May 15, 2009

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Pubmed Data : Free Radic Biol Med. 2009 May 15;46(10):1319-27. Epub 2009 Feb 25. PMID: 19248828

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Pubmed Data : Am J Epidemiol. 2006 Nov 1;164(9):898-906. Epub 2006 Jul 26. PMID: 16870699

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Pubmed Data : PLoS One. 2017 ;12(8):e0182048. Epub 2017 Aug 1. PMID: 28763509

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Dementia

Therapeutic Actions : Mediterranean diet

Pharmacological Actions : Neuroprotective Agents

[+]

Decreased brain volume in adults with childhood lead exposure.May 26, 2008

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Pubmed Data : PLoS Med. 2008 May 27 ;5(5):e112. PMID: 18507499

Article Published Date : May 26, 2008

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease, Childhood Chemical Exposures, Childhood Cognitive Disorders, Lead Poisoning, Neurodegenerative Diseases

Problem Substances : Lead

Adverse Pharmacological Actions : Neurotoxic

[+]

Decreased salivary lactoferrin levels are specific to Alzheimer's disease Jun 18, 2020

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Pubmed Data : J Clin Neuromuscul Dis. 2008 Dec ;10(2):56-60. PMID: 19169091

Article Published Date : Nov 30, 2008

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Therapeutic Actions : Therapeutic Breathing

[+]

Dietary niacin may protect against Alzheimer's disease and age related cognitive decline.Jul 31, 2004

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Pubmed Data : J Neurol Neurosurg Psychiatry. 2004 Aug ;75(8):1093-9. PMID: 15258207

Article Published Date : Jul 31, 2004

Study Type : Human Study

Additional Links

Substances : Vitamin B-3 (Niacin)

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

Problem Substances : Cholinesterase Inhibitor Drugs

[+]

Fecal short chain fatty acids concentrations were significantly reduced in PD patients compared to controls.Oct 31, 2016

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Pubmed Data : Parkinsonism Relat Disord. 2016 Nov ;32:66-72. Epub 2016 Aug 26. PMID: 27591074

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Diseases : Dysbiosis, Parkinson's Disease

Additional Keywords : Microbiota, Risk Factors

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Fermented papaya has antioxidant actions in AD patients and that it may be a prophylactic food against neurological diseases associated with free radical overproduction.Dec 31, 2014

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Pubmed Data : Mediators Inflamm. 2015 ;2015:624801. Epub 2015 Apr 7. PMID: 25944987

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Papaya: Fermented

Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Significant Treatment Outcome

[+]

Folate intake below the recommended daily allowance may increase risk for mild cognitive impairment and probable dementia in later life.Jan 31, 2015

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Pubmed Data : J Acad Nutr Diet. 2015 Feb ;115(2):231-41. Epub 2014 Sep 8. PMID: 25201007

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Pubmed Data : Fortschr Neurol Psychiatr. 2009 Sep;77(9):494-506. Epub 2009 Jul 20. PMID: 19621278

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba

Diseases : Dementia

Pharmacological Actions : Cardiovascular Agents

Additional Keywords : Donepezil Alternatives, Natural Substances Versus Drugs, Plant Extracts

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Ginkgo biloba extract may attentuate the neurotoxic effects of levodopa in parkinson disease.Jan 01, 2003

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID: 12973934

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Pubmed Data : Acta Neurol Scand. 2010 Feb;121(2):120-6. Epub 2009 Oct 5. PMID: 19804473

Article Published Date : Feb 01, 2010

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Problem Substances : L-glutamic Acid, Monosodium Glutamate (MSG)

Adverse Pharmacological Actions : Excitotoxic

[+]

Glyphosate has shown to be associated with the odds of premature mortality from Parkinson's disease.Dec 15, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neurology. 2020 Jan 29. Epub 2020 Jan 29. PMID: 31996451

Article Published Date : Jan 28, 2020

Higher vitamin D levels appear to be associated with better cognition, especially in areas of executive function and mental flexibility.Dec 31, 2018

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Pubmed Data : J Nutr Health Aging. 2019 ;23(8):725-731. PMID: 31560030

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Dementia, Memory Disorders, Vitamin D Deficiency

Pharmacological Actions : Neuroprotective Agents

[+]

Homocysteine-lowering therapy may prevent bone loss in Parkinson's disease patients taking levodopa.Feb 15, 2010

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Pubmed Data : Mov Disord. 2010 Feb 15;25(3):332-40. PMID: 19938151

Pubmed Data : J Alzheimers Dis. 2017 ;58(1):55-67. PMID: 28387676

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease, Fungus Diseases

Additional Keywords : Fungal Proteins, Risk Factors

[+]

Improved cognition while cycling in Parkinson's disease patients and healthy adults.Dec 31, 2016

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Pubmed Data : Brain Cogn. 2017 04 ;113:23-31. Epub 2017 Jan 11. PMID: 28088064

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Parkinson's Disease

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Neuroprotective Agents

[+]

Improved Executive Function and Callosal White Matter Microstructure after Rhythm Exercise in Huntington's Disease.Dec 31, 2013

Pubmed Data : J Alzheimers Dis. 2016 Mar 11. Epub 2016 Mar 11. PMID: 26967227

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Pubmed Data : BJU Int. 2007 Mar;99(3):619-22. Epub 2006 Nov 28. PMID: 19910450

Article Published Date : Mar 01, 2007

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis, Autoimmune Diseases, Celiac Disease

[+]

Kefir improves cognitive deficits.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neurobiol Aging. 2004 Mar;25(3):311-4. PMID: 15123336

Article Published Date : Mar 22, 2006

Study Type : Human Study

Additional Links

Substances : Coconut, Coconut Oil, Medium Chain Triglycerides

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

[+]

Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. Mar 11, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Med (Lausanne). 2018 ;5:279. Epub 2018 Oct 15. PMID: 30460234

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Diseases : Dementia

Therapeutic Actions : Music

[+]

N-acetylcysteine is associated with dopaminergic improvement in Parkinson's disease.Sep 30, 2019

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Pubmed Data : Clin Pharmacol Ther. 2019 Oct ;106(4):884-890. Epub 2019 Jul 17. PMID: 31206613

Click here to read the entire abstract

Pubmed Data : Neuroimage. 2016 May 1 ;131:226-38. Epub 2015 Oct 1. PMID: 26433119

Article Published Date : Apr 30, 2016

Study Type : Human Study

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

Therapeutic Actions : Exercise: Aerobic, Integrative Medicine

Pharmacological Actions : Neuroprotective Agents

[+]

Oxidative stress and inflammation are associated with physical frailty in patients with Alzheimer's disease.Jun 13, 2016

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Pubmed Data : Geriatr Gerontol Int. 2016 Jun 14. Epub 2016 Jun 14. PMID: 27296166

Article Published Date : Jun 13, 2016

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease, Inflammation, Oxidative Stress

[+]

Pantothenate deficiency could lead to neurodegeneration/dementia in Huntington's disease that might be preventable by treatment with vitamin B5.Jun 10, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Metabolites. 2019 Jun 11 ;9(6). Epub 2019 Jun 11. PMID: 31212603

Article Published Date : Jun 10, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin B-5 (Pantothenic Acid)

Diseases : Dementia, Huntington Disease, Neurodegenerative Diseases, Vitamin B Deficiency

Pharmacological Actions : Neuroprotective Agents

[+]

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The Following are Sub-Topics of Neurodegenerative Diseases

View the Evidence: 2425 Abstracts with Neurodegenerative Diseases Research

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21 percent of patients who receive donepezil discontinue treatment due to adverse side effects.Dec 07, 2009

A growing body of evidence supports qigong and tai chi performed as qigong as valid complementary or alternative therapeutic exercises.May 31, 2019

A systematic review and meta-analysis of the risk of dementia associated with benzodiazepine use.Jun 19, 2018

Acupuncture may be effective in improving cognitive function in vascular dementia animal models.Nov 12, 2018

Alzheimer disease is associated with a low concentration of serum vitamin E in older people.Aug 22, 2017

Alzheimer's disease cases have lower serum vitamin D concentrations than matched controls. Oct 04, 2012

An increased peripheral level of inflammatory markers is associated with a modest increase in risk of all-cause dementia.Mar 31, 2013

Antidepressant drug usage is associated with higher odds of Alzheimer’s disease and dementia.Dec 27, 2016

Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia.Dec 31, 2014

Cholinesterase inhibitor drug use is associated with increased incidence of bradycardia.Nov 01, 2009

Donepezil and memantine are known to cause bradycardia and to reduce the epileptogenic threshold.May 01, 2010

Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis.Dec 31, 2017

Effectiveness of Tai Chi for health promotion for adults with health conditions: a scoping review of Meta-analyses.Feb 17, 2020

Efficacy of ethyl-EPA as a treatment for Huntington disease.Mar 19, 2019

Ginkgo biloba appears more effective than placebo.Jan 01, 2010

Ginkgo biloba is potentially beneficial for the improvement of cognitive function in patients with mild cognitive impairment or Alzheimer's disease.Dec 31, 2015

Higher coffee consumption is associated with reduced risk for Alzheimer disease.May 31, 2016

Higher levels of serum 25(OH)D was associated with a lower risk of dementia and Alzheimer's disease.Feb 14, 2018

Huperzine A appears to have beneficial effects on improvement of cognitive function.Dec 31, 2012

Huperzine A is a well-tolerated drug that could significantly improve cognitive performance in patients with Alzheimer's disease and vascular dementia.Dec 31, 2013

In this meta-analysis, there was an observed increased risk of amytrophic lateral sclerosis in workers occupationally exposed to extremely low frequency electromagnetic fields. Feb 01, 2018

Increased consumption of fruit and vegetables is associated with a reduced risk of cognitive impairment and dementia.Dec 31, 2016

Light alcohol intake may protect against dementia, while excessive drinking may instead increase the risk.Jan 16, 2017

Memantine does not appear to have proven benefit for mild to moderate alzheimer disease.Jan 01, 2005

Meta-analytic findings suggested overall benefits of EGb 761 for stabilizing or slowing decline in cognition of subjects with cognitive impairment and dementia.Dec 31, 2014

Music could be a powerful treatment strategy in dementia.Dec 31, 2019

Music therapy exerted a moderately large effect on disruptive behaviours of people with dementia, a moderate effect on anxiety levels and depressive moods.Aug 23, 2015

Occupational exposure to pesticides appears to increases the risk of Parkinson's disease.Sep 30, 2012

People with various levels of cognitive impairment can benefit from supervised multi-modal exercise.Dec 26, 2017

Prescribing of antipsychotic drugs for dementia or for other mental health care should be avoided.Feb 01, 2018

Reduced exposure to sunlight were significantly associated with an increased risk of Parkinson's disease.Jan 22, 2019

Results of this meta-analytic study suggested that T. gondii can be considered a risk factor for the development of Alzheimer's disease.Sep 15, 2019

Tai Chi and Qigong is beneficial for improving motor function, depression and quality of life for individuals with Parkinson's disease.May 24, 2017

Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.Dec 31, 2014

The results confirm the efficacy of the three herbal active substances in elderly patients with anxiety, depression, and dementia.Jun 19, 2015

There is an association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis.Feb 01, 2003

These findings indicate a potential therapeutic role of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucosidein Alzheimer's disease therapy.Aug 25, 2016

These results suggested that exercise programs might play an important role in cognition and activities of daily living in patients with dementia.Dec 31, 2018

This meta-analysis found a statistically significant increase in the risk of dementia among patients with rheumatoid arthritis.Dec 31, 2015

This meta-analysis provided some evidence that melatonin improves sleep quality in patients with AD and PD.Aug 08, 2015

This meta-analysis suggests that physical activity interventions positively influence cognitive function in patients with dementia.Dec 31, 2015

This meta-analysis supports the hypothesis that proton pump inhibitors increase the risk of dementia.Nov 20, 2019

This study shows a strongly positive association between bacterial infection and Alzheimer's disease.Dec 31, 2014

Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis.Nov 12, 2019

Vitamin D, cognition, and dementia: a systematic review and meta-analysis.Sep 24, 2012

"Tai chi training appears to reduce balance impairments in patients with mild-to-moderate Parkinson's disease, with additional benefits of improved functional capacity and reduced falls."Feb 09, 2012

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

A higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS.Dec 19, 2003

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

A majority of patients with amyotrophic lateral sclerosis had signs of intestinal inflammation.Aug 31, 2017

A multi-vitamin/nutrient formula has therapeutic value in early-stage Alzheimer's diease. Dec 01, 2008

A multi-vitamin/nutrient formula has therapeutic value in moderate-stage to later-stage Alzheimer's diease. Feb 01, 2009

A naturally occuring L-Dopa rich plant extract of Mucuna pruriens was found to be an effective treatment for patients with Parkinson's disease.Sep 01, 1995

A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae.Feb 28, 2019

A polyphenol pattern provided by a diet containing specific plant products was associated with lower dementia risk.May 28, 2018

A single bout of aerobic exercise improves motor skill consolidation in Parkinson's disease.Dec 31, 2017

A supplement containing huperzine A and curcumin in dementia patients and individuals with mild cognitive impairment had beneficial effects.Dec 31, 2017

Acupressure is effective in reducing both agitation and stress residents with dementia. Aug 29, 2016

Acupuncture improves the overall function, cognition and activity of daily life in patients and the efficacy was superior to donepezil.Nov 30, 2014

Acupuncture in combination with Madopa may improve cerebral glucose metabolism in Parkinson's disease.Oct 01, 2007

Acupuncture is a safe and is effective in improving the cognitive function and global clinical status of Alzheimer's disease.Dec 28, 2017

Acute cannabidiol administration at a dose of 300 mg decreased anxiety in patients with Parkinson's disease.Jan 06, 2020

Adding medical cannabis oil to AD patients' pharmacotherapy is safe and a promising treatment option.Jan 11, 2016

Adherence to the Mediterranean may positively affect not only the risk of AD, but also of predementia syndromes and their progression to overt dementia. May 01, 2011

Administration of saffron capsules was comparable with memantine in reducing cognitive decline in patients with moderate to severe AD.Jun 30, 2014

Aerobic exercise in early Alzheimer’s disease is associated with benefits in functional ability.Dec 31, 2016

Aerobic exercise sustains performance of instrumental activities of daily living in early-stage Alzheimer disease.Dec 27, 2017

Aerobic fitness may have a positive influence on protection of brain even in aMCI CSF biomarker, a high-risk population to convert to AD.May 31, 2016

Ai Chi exercises should be considered as a rehabilitation option for treatment of patients with mild or moderate Parkinson's disease.Mar 31, 2018

Alcohol use disorders were a major risk factor for onset of all types of dementia.Feb 19, 2018

Alpha lipoic acid is an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Oct 01, 2008

Alpha lipoic appears to be an effective neuroprotective agent in Alzheimer's disease. Jan 01, 2007

Neurodegenerative Diseases

View the Evidence:
2425 Abstracts with Neurodegenerative Diseases Research