Neurodegenerative Diseases

Name	AC	CK
Vitamin D	25	340
Curcumin	127	251
Ginkgo biloba	37	231
Melatonin	40	151
Vitamin B-12	17	131
Huperzine	25	124
Vitamin E	21	122
Ginsenosides	60	118
Cannabidiol	41	116
Coenzyme Q10	23	115
Resveratrol	66	105
Folic Acid	18	96
Flavonoids	40	95
Polyphenols	46	88
Catechin	22	75
Cannabis	17	65
Coconut Oil	13	64
EGCG (Epigallocatechin gallate)	41	64
Vitamin B-6	10	60
Probiotics	21	59
Cannabinoids	31	58
Coffee	8	57
B-complex	6	55
Vitamin C	23	54
Vegetables: All	7	53
Berberine	34	51
Thymoquinone	27	51
Alpha-Lipoic Acid	14	50
Bacopa	25	49
Omega-3 Fatty Acids	15	49
Astaxanthin	30	46
Saffron	18	45
Bee Venom	14	44
Lavender: Essential Oil	5	44
Anthocyanins	17	43
Delta-tetrahydrocannabinol (THC)	11	43
Fruit: All	5	42
Lemon Balm	4	42
Sage	5	42
Mucuna pruriens (aka Velvet Beans)	13	41
Green Tea	20	40
Olive Oil	13	40
Puerarin	20	40
Rosmarinic acid	10	40
Baicalein	11	38
Carotenoids	7	38
NAC (N-acetyl-L-cysteine)	8	38
Quercetin	25	38
Tanshinone IIA	18	38
Crocin	18	37
EPA (Eicosapentaenoic Acid)	6	37
Polyunsaturated Fatty Acids (PUFAs)	6	37
Lutein	6	36
DHA (Docosahexaenoic Acid)	15	35
Lion's Mane (Hericium Erinaceus)	10	34
Lycopene	16	33
Nobiletin	13	33
Rosemary	8	32
SAMe (S-adenosylmethionine)	4	32
Genistein	20	31
Selenium	9	31
Fucoidan	16	30
Naringenin	19	30
Vitamin B-5 (Pantothenic Acid)	1	30
Caffeine	10	29
Palmitoylethanolamide	11	29
Ashwagandha	16	28
Fisetin	15	28
Fish Oil	6	28
Paeoniflorin	17	28
Tea	15	28
Gastrodin	16	27
Carvacrol	9	26
Strawberry	7	26
Thiamine (B-1)	5	26
Lactoferrin	5	25
Pomegranate	13	25
Safflower	15	25
Turmeric	14	25
Holy Basil	3	24
Sulforaphane	14	24
Ginseng (Korean)	12	23
Vitamin B12: methylcobalamin	5	23
Gotu Kola	14	22
Piperidines	2	22
Piperine	13	22
Vitamin B-3 (Niacin)	3	22
Ginger	12	21
Papaya: Fermented	2	21
Spermidine	2	21
Walnut	13	21
Carnitine, Acetyl-L-	2	20
Rose	6	20
St. John's Wort	1	20
Lychee	9	19
Nigella sativa (aka Black Seed)	10	19
Reishi Mushroom	9	19
Creatine	4	18
Luteolin	10	18
Stilbenes	10	18
Chrysin	9	17
Red Wine Extract	4	17
6-Shogaol	9	16
Antioxidant formulas	5	16
Apigenin	8	16
Carnosic Acid	7	16
Citrus naringin	9	16
Prebiotics	5	16
Royal Jelly	11	16
Silibinin	6	16
Zinc	4	16
Asiatic Acid	10	15
Blueberry	10	15
Estradiol (E(2))	8	15
Grape	4	15
Hesperidin	8	15
Honokiol	8	15
Mangiferin	8	15
Mangosteen	8	15
Phloretin	5	15
Progesterone	4	15
Apples	3	14
Bamboo	5	14
Coconut	4	14
Ellagic Acid	8	14
Glutathione	5	14
Grape Seed Extract	6	14
Hydroxytyrosol	10	14
Lavender	3	14
Licorice	9	14
Magnesium	8	14
Myricetin	10	14
Testosterone	3	14
Amla Fruit	5	13
Astragaloside	10	13
Black Currant	3	13
Ginseng	8	13
Kefir	2	13
Medium Chain Triglycerides	2	13
Oleuropein	10	13
Persimmon	7	13
Spirulina	6	13
Thymol	6	13
Cinnamon	8	12
Citrus Peel	5	12
Culinary Herbs and Spices	2	12
Folate	2	12
Fucoxanthin	7	12
Green Coffee Bean	2	12
Oleocanthal	5	12
Phosphatidylserine	2	12
Pycnogenol (Pine Bark)	2	12
Rutin	7	12
Tangeretin	6	12
Berries: All	2	11
Black Tea	7	11
Chokeberry	6	11
Copper	2	11
Goji	7	11
Lotus	7	11
Paeonol	7	11
Schisandra	6	11
Ursolic Acid	6	11
Brown Rice	1	10
Chlorogenic Acid	5	10
Cholesterol	1	10
Curry Spice	1	10
Eicosapentaenoic acid (EPA)	2	10
Ferulic acid	5	10
GlyceroPhosphoCholine (alpha-GPC)	1	10
Melissa (Lemonbalm)	1	10
Monounsaturated fatty acids	1	10
Nuts	1	10
Rosemary: Essential Oil	1	10
S-Adenosylmethionine (SAMe)	5	10
Sea Cucumber	1	10
Seaweed: Brown	4	10
Silica	1	10
Silica: Orthosilicic acid	1	10
Superoxide dismutase	1	10
Theanine	6	10
Tomato	1	10
Whey	1	10
Zeaxanthin	1	10
Black Pepper	5	9
Honeysuckle	8	9
Hydrogen Water	3	9
Lactobacillus plantarum	4	9
Passion Flower	4	9
Peony	5	9
Rosemaric Acid	6	9
Syrian rue	5	9
Biochanin A	5	8
Emodin	3	8
Glycoaminoglycans	4	8
Gynostemma	5	8
Isoflavones	2	8
Plum	3	8
Rice Bran	3	8
Sesamin	4	8
Sesamol	4	8
Spikenard	4	8
Antrodia camphorata	3	7
Brown Rice: Pre-Germinated	2	7
Carnosine	5	7
Crocetin	4	7
Echinacea	4	7
Fermented Foods and Beverages	5	7
Frankincense	4	7
Garlic	5	7
Insulin-like Growth Factor (IGF-1)	4	7
Moringa oleifera	4	7
Mulberry	4	7
Panax Notoginseng	4	7
Pterostilbene	5	7
Safranal	4	7
Theaflavins	3	7
Vanillin	3	7
Vitexins	5	7
beta-Carotene	4	7
Betulinic acid	3	6
Chinese Skullcap	4	6
Daidzein	2	6
Demethoxycurcumin	4	6
Diosgenin	3	6
Eriodictyol	2	6
False Black Pepper	4	6
Fenugreek	3	6
Formononetin	4	6
Gingerol	3	6
Gold (nanoparticles)	3	6
Magnolol	3	6
Olive	3	6
Piperlongumine	4	6
Pomegranate Peel	2	6
Urolithin A	3	6
Wine	2	6
Acetyl-l-carnitine	3	5
Agaricus Blazei	3	5
Amurensin G	1	5
Barberry	4	5
Basil	3	5
Beta-Caryophyllene	3	5
Blackberry	4	5
Bromelain	1	5
Caffeic Acid	3	5
Caffeic acid phenethyl ester	3	5
Caprylic Acid	2	5
Cinnamaldehyde	3	5
Dogwood	4	5
Essential Fatty Acids	2	5
Geraniol	3	5
Hawthorn	4	5
Hibiscus sabdariffa	4	5
Kimchi	3	5
Long Pepper	3	5
Medicinal Mushrooms	2	5
Oleanolic acid	4	5
Pistachio nut	3	5
Raspberry	4	5
Red Sage	3	5
Riboflavin (Vitamin B-2)	3	5
St. Johns Wort	3	5
Toona sinensis	3	5
Verbascoside	3	5
Zataria multiflora	3	5
Zerumbone	3	5
Angelica	2	4
Avocado	1	4
Ayahuasca	3	4
Bay leaf	1	4
Bifidobacterium Breve	2	4
Bifidobacterium Lactis	2	4
Bifidobacterium Longum	2	4
Bitter Orange	2	4
Carnosol	2	4
Cocoa	3	4
Cordyceps sinensis	2	4
Cysteine (see N-Acetylcysteine)	1	4
Dopa bean	2	4
Epicatechin	2	4
Eugenol	2	4
Garlic: Aged	2	4
Ginseng (American)	2	4
Guarana	1	4
Guduchi	3	4
Indian Mulberry	2	4
Jujube	2	4
Ligustrazine	2	4
Lupeol	1	4
Mushrooms: All	2	4
Nettle	2	4
Olive leaf extract	3	4
Panax Ginseng	2	4
Perilla	3	4
Piceatannol	3	4
Policosanol	2	4
Prunella vulgaris	2	4
Psyllium	2	4
Punicalagin	4	4
Purslane	2	4
Radish	2	4
Soy	1	4
Soy Protein	1	4
Tetrahydrocurcumin	1	4
Ume (Japanese apricot)	2	4
Allicin	2	3
Apple	2	3
Arginine	2	3
Babchi	2	3
Bael	2	3
Bee Propolis	3	3
Bisdemethoxycurcumin	3	3
Black Tea Theaflavins	2	3
Butyrate	2	3
Cashew	2	3
Chaenomeles speciosa	2	3
Chia	2	3
Coptis chinensis	2	3
Cordyceps Militaris	2	3
Cranberry	2	3
Cyanidin	3	3
Dandelion	3	3
Genipin	1	3
Honey	3	3
Hyperforin	2	3
Indole-3-Carbinol	2	3
Isothiocyanate	2	3
Japanese mugwort	2	3
Kaempferol	2	3
Kudzu	2	3
Lactobacillus probiotics	2	3
Lignans	2	3
Maple Syrup	2	3
Melanin: Bacterial	2	3
Milk Thistle	2	3
Multivitamin	1	3
Nicotinamide adenine dinucleotide (NADH)	2	3
Noni	2	3
Nordihydroguaiaretic acid (NDGA)	2	3
Oligosaccharides	2	3
Onion	2	3
Rhubarb	2	3
Ruta Graveolens	1	3
Salvia miltiorrhiza	3	3
Silymarin	2	3
Tannic Acid	2	3
Tauroursodeoxycholic acid	2	3
Turmerones	2	3
Water: Deuterium Depleted	1	3
Wogonin	2	3
Xanthohumol	3	3
Xanthones	2	3
18β-Glycyrrhetinic Acid	1	2
5-HTP (5-Hydroxytryptophan)	1	2
Algae	1	2
Almond	2	2
Amino Acids: Branched Chain	1	2
Anise	1	2
Apple Cider Vinegar	1	2
Arctigenin	1	2
Ayurvedic Formulation: Chyawanprash	1	2
Beet	1	2
Bergamot	2	2
Beta Sitosterol	1	2
Bifidobacterium Bifidum	1	2
Bilberry	1	2
Butterbur	1	2
Caffeoylquinic Acids	1	2
Cannabinoids: Synthetic	2	2
Capparis spinosa (caper)	1	2
Celastrol	1	2
Celery	1	2
Chaga Mushroom (Inonotus obliquus)	1	2
Cherry: All Varieties	1	2
Chromium	1	2
Coconut Water	1	2
Cucurbitacin E	1	2
Curcuminoids	2	2
Curry Tree	1	2
Cyanidin 3-glucoside	1	2
Date Seeds	1	2
Eicosanoyl-5-hydroxytryptamide (EHT)	1	2
Elderberry	2	2
Essential Oils: Unspecified	1	2
Evening Primrose Oil	1	2
Evodia ruteacarpa	1	2
FOS (Fructooligosaccharides)	1	2
Fennel	1	2
Fig	1	2
Galactooligosaccharides	1	2
Gallic Acid	2	2
Ginseng (Asian)	1	2
Grapefruit Seed Extract	1	2
Grewia Asiatica	1	2
Hazelnut	2	2
Hemp Seed	2	2
Hops	1	2
Icariin	1	2
Isoliquiritigenin	2	2
Kava Kava	2	2
Kiwifruit	1	2
Krill	1	2
Lactobacillus Acidophilus	1	2
Lactobacillus fermentum	1	2
Lactobacillus helveticus	1	2
Lauric acid	2	2
Liquiritigenin	2	2
Loquat	1	2
Lysine	1	2
Mango	1	2
Mango leaf	1	2
Marijuana	1	2
Mint	1	2
Moxibustion	1	2
Myrtle	1	2
Nattokinase	1	2
Niacin	1	2
Octacosanol	1	2
Oregano	1	2
Oridonin	1	2
Orthosiphon	1	2
Pantethine	1	2
Pantothenic Acid (Vitamin B-5)	1	2
Pine Bark Extract	1	2
Poria cocos	1	2
Prickly Pear Cactus	1	2
Propolis: Bee	1	2
Propolis: Brazillian	2	2
Pumpkin Seeds	1	2
Pyruvate	1	2
Raisins	1	2
Red Clover	1	2
Red Yeast Rice	1	2
Rooibos	1	2
Rose Hips	1	2
Sandalwood	1	2
Satsuma	1	2
Scolopendra subspinipes mutilans	1	2
Sesame Seeds	1	2
Shikonin	1	2
Soursop	1	2
Star Fruit	1	2
Sweet Potato: Purple	1	2
Tart Cherry	1	2
Terminalia chebula	1	2
Tocotrienol: Delta	1	2
Tyrosine	1	2
Ubiquinol	1	2
Valerian	1	2
Vitamin A	1	2
Vitamin E: alpha tocopherol	2	2
Vitamin K2	1	2
Wen Pi Tang	1	2
White Tea	2	2
Yeast	1	2
Yerba Mate	1	2
acetyl-11-keto-beta-boswellic acid	1	2
phytoestrogens	1	2
Acacia catechu	1	1
Achillea fragrantissima	1	1
Apple Polyphenols	1	1
Asparagus	1	1
Astragalus	1	1
Banana	1	1
Beta-glucan	1	1
Betanin	1	1
Black Raspberry	1	1
Blue Honeysuckle	1	1
Boerhaavia diffusa	1	1
Brazil nut	1	1
Broccoli Sprouts	1	1
Brussel sprouts	1	1
Cannabichromene	1	1
Cannabigerol	1	1
Cardamom	1	1
Cardamonin	1	1
Carnitine	1	1
Carob	1	1
Carpolobia lutea	1	1
Catechols	1	1
Chickpea	1	1
Chili pepper	1	1
Choline	1	1
Chrysanthemum Indicum	1	1
Clove	1	1
Codonopsis pilosula	1	1
Coffee: Green/Unroasted	1	1
Colostrum	1	1
Coriandor	1	1
Coriandrum sativum	1	1
Corn Silk	1	1
Coumestrol	1	1
Cumin	1	1
Daisy	1	1
Devils Claw	1	1
Endocannabinoids	1	1
Fiber	1	1
Ginseng (Siberian)	1	1
Glycyrrhiza uralensis	1	1

Name	AC	CK
Aluminum	53	102
Donepezil (trade name Aricept)	7	100
Cholinesterase Inhibitor Drugs	6	86
Memantine	5	84
Pesticides	11	69
Lead	12	58
Statin Drugs	7	55
Proton-Pump Inhibitors	4	51
Antidepressants	2	50
Aluminum Chloride	18	42
Antipsychotic Drugs	3	40
Rotenone	20	36
Benzodiazepines	2	30
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	5	26
Tobacco	2	20
Glyphosate	6	17
Mercury	4	17
Monosodium Glutamate (MSG)	4	16
Bisphenol A	4	14
Antibiotics	3	13
Rivastigmine	2	13
Paraquat	6	12
Agricultural Chemicals	1	10
Artificially Sweetened Beverages	1	10
Calcium Supplements	1	10
Dental Amalgams	1	10
Hydrogenated Oil	1	10
L-glutamic Acid	1	10
Nicotine	1	10
Organochlorine pesticides	1	10
Persistent organic pollutants (POPs)	1	10
Radon	1	10
Zolpidem (trade name Ambien)	1	10
Lyme's Disease (Borrelia burgdorferi)	3	9
Thimerosal	4	8
Sodium Fluoride	4	7
Formaldehyde	3	6
Cell Phone Exposure	3	5
Chlorpyrifos	4	5
Glucose	1	5
Herbicides	1	5
Vaccine Adjuvants	4	5
Acrylamide	2	4
Aluminum oxide	1	4
Aspartame	2	4
Cadmium	3	4
Fluoride	2	4
Glyphosate formulations	1	4
Heavy Metals	3	4
Roundup (herbicide)	1	4
Atorvastatin	2	3
Eptastigmine	1	3
Galantamine	1	3
Arsenite	1	2
Canola Oil	1	2
Cypermethrin	1	2
Electronic Cigarettes	1	2
Flame Retardants	1	2
Gluten	2	2
Lovastatin	1	2
Organophosphates	1	2
Polychlorinated biphenyls (PCBs)	1	2
Streptozotocin	1	2
Tamoxifen	1	2
Toluene	1	2
Tricresyl phosphates (TCPs)	1	2
Acetaminophen	1	1
Alcohol Consumption	1	1
Aluminium Cans	1	1
Cholesterol Lowering Drugs	1	1
Cobalt	1	1
Cow Milk	1	1
Dimethoate	1	1
Excitotoxins	1	1
Infant Formula	1	1
Nonylphenol	1	1
Nonylphenol Ethoxylate (NPE)	1	1
Paracetamol	1	1
Simvastatin	1	1
Stannous chloride	1	1
Sugary soda	1	1
Tertiary butyl hydroperoxide	1	1
Zineb	1	1

Name	AC	CK
Exercise	81	396
Music	13	116
Qigong	7	110
Exercise: Aerobic	9	103
Acupuncture	15	101
Tai Chi	8	100
Dietary Modification: Mediterranean Diet	8	53
Dietary Modification: Low Carbohydrate/Ketogenic	14	51
Electroacupuncture	17	49
Meditation	6	46
Exercise: Cycling	4	40
Aromatherapy	4	32
Ai-Chi Aquatic Exercise	3	30
Dancing	3	30
Massage/Therapeutic Touch	3	30
Mindfullness Training	2	30
Sunlight exposure	2	30
Therapeutic Breathing	2	30
Light-Emitting Diodes (LEDs) Therapy	2	26
Yoga	6	26
Laser Treatment: Low-Level	9	24
Drumming	2	20
Stem Cell Related Therapy	4	15
Acupressure	2	11
Horticultural Therapy (Gardening)	2	11
Integrative Medicine	2	11
Acupuncture: auricular	1	10
Animal Therapy	1	10
Aromatherapy Massage	1	10
Exercise: Endurance	1	10
Guided Imagery	1	10
Laughter/Humor	1	10
Loving	1	10
Mediterranean diet	1	10
Relaxation Therapy	1	10
Spiritual/Religious Practice	1	10
Fasting/Caloric Restriction	6	9
Exercise: Swimming	2	4
Hyperbaric Treatment	2	4
Mind-Body Therapies	1	4
Melodic Intonation Therapy	2	3
Art Therapy	1	2
Exercise: Running	1	2
Intermittent Hypoxia (low oxygen)	1	2
Light Therapy	1	2
Aquatic therapy	1	1
Craniosacral Therapy	1	1
Dietary Modification: High-Fat/Low-Carbohydrate	1	1
Magnet Therapy	1	1
Microbiota Transfer Therapy	1	1

Name	AC	CK
Electromagnetic Field Harms	16	75
Electromagnetic Radiation	13	51
Vaccination: All	19	34
Overdiagnosis	2	20
Shift Work	1	20
Western Diet	4	16
Low Dose Ionizing Radiation	1	10
Mobile Phone Radiation	6	9
Wi-Fi Radiation	3	5
Electromagnetic Radiation: 2.4 GHz	2	4
Microwave Radiation	2	3
Air Travel	1	2
Nanotechnology	1	2

Problem Substances : Benzodiazepines

[+]

Acupuncture may be effective in improving cognitive function in vascular dementia animal models.Nov 12, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Aging Neurosci. 2020 ;12:277. Epub 2020 Sep 25. PMID: 33101006

Article Publish Status : This is a free article. Click here to read the complete article.

Huperzine A is a well-tolerated drug that could significantly improve cognitive performance in patients with Alzheimer's disease and vascular dementia.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Alzheimers Dis. 2015 ;43(2):605-11. PMID: 25352453

Article Published Date : Dec 31, 2014

Study Type : Meta Analysis

Additional Links

Substances : Ginkgo biloba

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction, Dementia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Music could be a powerful treatment strategy in dementia.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharm Health Care Sci. 2015 ;1:14. Epub 2015 Apr 10. PMID: 26819725

Pubmed Data : Clin Nutr. 2021 May 21 ;40(6):3922-3930. Epub 2021 May 21. PMID: 34139465

Click here to read the entire abstract

Pubmed Data : J Psychopharmacol. 2020 Jan 7:269881119895536. Epub 2020 Jan 7. PMID: 31909680

Pubmed Data : Hum Psychopharmacol. 2014 Jul ;29(4):351-9. PMID: 25163440

Article Published Date : Jun 30, 2014

Study Type : Human Study

Additional Links

Substances : Saffron

Diseases : Alzheimer's Disease

Additional Keywords : Natural Substances Versus Drugs, Phytotherapy, Plant Extracts

Problem Substances : Memantine

[+]

Aerobic exercise in early Alzheimer’s disease is associated with benefits in functional ability.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Am J Alzheimers Dis Other Demen. 2003 Nov-Dec;18(6):353-8. PMID: 14682084

Article Published Date : Nov 01, 2003

Study Type : Human Study

Additional Links

Diseases : Dementia

Therapeutic Actions : Animal Therapy

[+]

Antioxidant beverages could be used as a natural complementary therapy to alleviate or decrease oxidative stress in Alzheimer’s disease.Aug 22, 2015

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Pubmed Data : Eur J Nutr. 2015 Aug 23. Epub 2015 Aug 23. PMID: 26298312

Association between anticholinergic medication use and risk of dementia among patients with Parkinson's disease.Jun 27, 2019

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Pubmed Data : Pharmacotherapy. 2019 Jun 28. Epub 2019 Jun 28. PMID: 31251824

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Pubmed Data : J Alzheimers Dis. 2019 Dec 2. Epub 2019 Dec 2. PMID: 31815694

Article Published Date : Dec 01, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction, Vitamin D Deficiency

Pharmacological Actions : Neuroprotective Agents

[+]

Cocoa procyanidins attenuate lipid peroxidation associated neuronal cell death in a manner relevant to Alzheimer's disease.May 15, 2009

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Pubmed Data : Free Radic Biol Med. 2009 May 15;46(10):1319-27. Epub 2009 Feb 25. PMID: 19248828

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Pubmed Data : Am J Epidemiol. 2006 Nov 1;164(9):898-906. Epub 2006 Jul 26. PMID: 16870699

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(8):e0182048. Epub 2017 Aug 1. PMID: 28763509

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Dementia

Therapeutic Actions : Mediterranean diet

Pharmacological Actions : Neuroprotective Agents

[+]

Decreased brain volume in adults with childhood lead exposure.May 26, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS Med. 2008 May 27 ;5(5):e112. PMID: 18507499

Article Published Date : May 26, 2008

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease, Childhood Chemical Exposures, Childhood Cognitive Disorders, Lead Poisoning, Neurodegenerative Diseases

Problem Substances : Lead

Adverse Pharmacological Actions : Neurotoxic

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Decreased salivary lactoferrin levels are specific to Alzheimer's disease Jun 18, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Clin Neuromuscul Dis. 2008 Dec ;10(2):56-60. PMID: 19169091

Article Published Date : Nov 30, 2008

Study Type : Human Study

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Diseases : Amyotrophic Lateral Sclerosis

Therapeutic Actions : Therapeutic Breathing

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Dietary niacin may protect against Alzheimer's disease and age related cognitive decline.Jul 31, 2004

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Pubmed Data : J Neurol Neurosurg Psychiatry. 2004 Aug ;75(8):1093-9. PMID: 15258207

Article Published Date : Jul 31, 2004

Study Type : Human Study

Additional Links

Substances : Vitamin B-3 (Niacin)

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

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Additional Keywords : Natural Substances Versus Drugs

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Efficacy of tanshinone IIA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia.Dec 31, 2020

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Pubmed Data : J Tradit Chin Med. 2021 02 ;41(1):133-139. PMID: 33522206

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Tanshinone IIA

Diseases : Dementia

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Additional Keywords : Mesenchymal Stem Cells

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Eiocosapentaenoic acid significantly reduces brain atrophy in Huntington's disease. Sep 01, 2008

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Pubmed Data : J Int Med Res. 2008 Sep-Oct;36(5):896-905. PMID: 18831882

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Substances : Eicosapentaenoic acid (EPA) , EPA (Eicosapentaenoic Acid)

Diseases : Huntington Disease

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Electro-acupuncture add-on treatment markedly improves activity of daily living and quality of life of Parkinson's disease patients.Dec 31, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:692795. Epub 2015 Aug 13. PMID: 26351515

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Pubmed Data : J Alzheimers Dis. 2015 Dec 10 ;50(2):443-53. PMID: 26682695

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Pubmed Data : Parkinsonism Relat Disord. 2016 Nov ;32:66-72. Epub 2016 Aug 26. PMID: 27591074

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Diseases : Dysbiosis, Parkinson's Disease

Additional Keywords : Microbiota, Risk Factors

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Fermented papaya has antioxidant actions in AD patients and that it may be a prophylactic food against neurological diseases associated with free radical overproduction.Dec 31, 2014

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Pubmed Data : Mediators Inflamm. 2015 ;2015:624801. Epub 2015 Apr 7. PMID: 25944987

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Pubmed Data : Eur J Neurol. 2006 Sep;13(9):981-5. PMID: 16930364

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba, Piperidines

Diseases : Alzheimer's Disease, Dementia

Additional Keywords : Donepezil Alternatives, Natural Substances Versus Drugs, Plant Extracts

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Gingko biloba compares favorably to the drug donepezil in the treatment of dementia.Sep 01, 2009

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Pubmed Data : Fortschr Neurol Psychiatr. 2009 Sep;77(9):494-506. Epub 2009 Jul 20. PMID: 19621278

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba

Diseases : Dementia

Pharmacological Actions : Cardiovascular Agents

Additional Keywords : Donepezil Alternatives, Natural Substances Versus Drugs, Plant Extracts

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Ginkgo biloba extract may attentuate the neurotoxic effects of levodopa in parkinson disease.Jan 01, 2003

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID: 12973934

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Pubmed Data : Acta Neurol Scand. 2010 Feb;121(2):120-6. Epub 2009 Oct 5. PMID: 19804473

Article Published Date : Feb 01, 2010

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis

Problem Substances : L-glutamic Acid, Monosodium Glutamate (MSG)

Adverse Pharmacological Actions : Excitotoxic

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Glyphosate has shown to be associated with the odds of premature mortality from Parkinson's disease.Dec 15, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Dement Geriatr Cogn Disord. 2010 Jul;29(6):553-9. Epub 2010 Jul 3. PMID: 20606437

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis, Hyperhomocysteinemia, Parkinson's Disease, Supranuclear Palsy: Progressive

Additional Keywords : Diseases that are Linked

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High homocysteine levels may be associated with the pathogenesis of neurological disorders.Jan 01, 2010

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Pubmed Data : Front Biosci (Schol Ed). 2010;2:359-72. Epub 2010 Jan 1. PMID: 20036953

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : B-complex

Diseases : Alzheimer's Disease, Amyotrophic Lateral Sclerosis,

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View the Evidence: 2719 Abstracts with Neurodegenerative Diseases Research

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21 percent of patients who receive donepezil discontinue treatment due to adverse side effects.Dec 07, 2009

A growing body of evidence supports qigong and tai chi performed as qigong as valid complementary or alternative therapeutic exercises.May 31, 2019

A systematic review and meta-analysis of the risk of dementia associated with benzodiazepine use.Jun 19, 2018

Acupuncture may be effective in improving cognitive function in vascular dementia animal models.Nov 12, 2018

Alzheimer disease is associated with a low concentration of serum vitamin E in older people.Aug 22, 2017

Alzheimer's disease cases have lower serum vitamin D concentrations than matched controls. Oct 04, 2012

An increased peripheral level of inflammatory markers is associated with a modest increase in risk of all-cause dementia.Mar 31, 2013

Antidepressant drug usage is associated with higher odds of Alzheimer’s disease and dementia.Dec 27, 2016

Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia.Dec 31, 2014

Baicalein exerts potential neuroprotective effects through multiple signaling pathways in animal models of Parkinson's disease.Dec 31, 2019

Cholinesterase inhibitor drug use is associated with increased incidence of bradycardia.Nov 01, 2009

Donepezil and memantine are known to cause bradycardia and to reduce the epileptogenic threshold.May 01, 2010

Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis.Dec 31, 2017

Effect of ginsenoside-Rg1 on experimental Parkinson's disease.May 31, 2021

Effectiveness of Tai Chi for health promotion for adults with health conditions: a scoping review of Meta-analyses.Feb 17, 2020

Efficacy of ethyl-EPA as a treatment for Huntington disease.Mar 19, 2019

Ginkgo biloba appears more effective than placebo.Jan 01, 2010

Ginkgo biloba is potentially beneficial for the improvement of cognitive function in patients with mild cognitive impairment or Alzheimer's disease.Dec 31, 2015

Higher coffee consumption is associated with reduced risk for Alzheimer disease.May 31, 2016

Higher levels of serum 25(OH)D was associated with a lower risk of dementia and Alzheimer's disease.Feb 14, 2018

Huperzine A appears to have beneficial effects on improvement of cognitive function.Dec 31, 2012

Huperzine A is a well-tolerated drug that could significantly improve cognitive performance in patients with Alzheimer's disease and vascular dementia.Dec 31, 2013

In this meta-analysis, there was an observed increased risk of amytrophic lateral sclerosis in workers occupationally exposed to extremely low frequency electromagnetic fields. Feb 01, 2018

Increased consumption of fruit and vegetables is associated with a reduced risk of cognitive impairment and dementia.Dec 31, 2016

Light alcohol intake may protect against dementia, while excessive drinking may instead increase the risk.Jan 16, 2017

Memantine does not appear to have proven benefit for mild to moderate alzheimer disease.Jan 01, 2005

Meta-analytic findings suggested overall benefits of EGb 761 for stabilizing or slowing decline in cognition of subjects with cognitive impairment and dementia.Dec 31, 2014

Music could be a powerful treatment strategy in dementia.Dec 31, 2019

Music therapy exerted a moderately large effect on disruptive behaviours of people with dementia, a moderate effect on anxiety levels and depressive moods.Aug 23, 2015

Occupational exposure to pesticides appears to increases the risk of Parkinson's disease.Sep 30, 2012

People with various levels of cognitive impairment can benefit from supervised multi-modal exercise.Dec 26, 2017

Prescribing of antipsychotic drugs for dementia or for other mental health care should be avoided.Feb 01, 2018

Qigong is a beneficial alternative therapy contributing to increasing motor function, walking ability, and balance for patients with Parkinson's disease.Nov 30, 2020

Reduced exposure to sunlight were significantly associated with an increased risk of Parkinson's disease.Jan 22, 2019

Results of this meta-analytic study suggested that T. gondii can be considered a risk factor for the development of Alzheimer's disease.Sep 15, 2019

Tai Chi and Qigong is beneficial for improving motor function, depression and quality of life for individuals with Parkinson's disease.May 24, 2017

Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.Dec 31, 2014

The impact of tai chi on motor function, balance, and quality of life in Parkinson's disease.Dec 31, 2020

The results confirm the efficacy of the three herbal active substances in elderly patients with anxiety, depression, and dementia.Jun 19, 2015

There is an association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis.Feb 01, 2003

These findings indicate a potential therapeutic role of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucosidein Alzheimer's disease therapy.Aug 25, 2016

These results suggested that exercise programs might play an important role in cognition and activities of daily living in patients with dementia.Dec 31, 2018

This meta-analysis found a statistically significant increase in the risk of dementia among patients with rheumatoid arthritis.Dec 31, 2015

This meta-analysis provided some evidence that melatonin improves sleep quality in patients with AD and PD.Aug 08, 2015

This meta-analysis suggests that physical activity interventions positively influence cognitive function in patients with dementia.Dec 31, 2015

This meta-analysis supports the hypothesis that proton pump inhibitors increase the risk of dementia.Nov 20, 2019

This study shows a strongly positive association between bacterial infection and Alzheimer's disease.Dec 31, 2014

Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis.Nov 12, 2019

Vitamin D, cognition, and dementia: a systematic review and meta-analysis.Sep 24, 2012

Vitamin E might have a protective effect against Parkinson's disease.May 20, 2021

"Tai chi training appears to reduce balance impairments in patients with mild-to-moderate Parkinson's disease, with additional benefits of improved functional capacity and reduced falls."Feb 09, 2012

A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS. Apr 01, 2007

A higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS.Dec 19, 2003

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

A majority of patients with amyotrophic lateral sclerosis had signs of intestinal inflammation.Aug 31, 2017

A multi-vitamin/nutrient formula has therapeutic value in early-stage Alzheimer's diease. Dec 01, 2008

A multi-vitamin/nutrient formula has therapeutic value in moderate-stage to later-stage Alzheimer's diease. Feb 01, 2009

A naturally occuring L-Dopa rich plant extract of Mucuna pruriens was found to be an effective treatment for patients with Parkinson's disease.Sep 01, 1995

A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae.Feb 28, 2019

A polyphenol pattern provided by a diet containing specific plant products was associated with lower dementia risk.May 28, 2018

A single bout of aerobic exercise improves motor skill consolidation in Parkinson's disease.Dec 31, 2017

A supplement containing huperzine A and curcumin in dementia patients and individuals with mild cognitive impairment had beneficial effects.Dec 31, 2017

Acupressure is effective in reducing both agitation and stress residents with dementia. Aug 29, 2016

Acupuncture improves the overall function, cognition and activity of daily life in patients and the efficacy was superior to donepezil.Nov 30, 2014

Acupuncture in combination with Madopa may improve cerebral glucose metabolism in Parkinson's disease.Oct 01, 2007

Acupuncture is a safe and is effective in improving the cognitive function and global clinical status of Alzheimer's disease.Dec 28, 2017

Acute cannabidiol administration at a dose of 300 mg decreased anxiety in patients with Parkinson's disease.Jan 06, 2020

Adding medical cannabis oil to AD patients' pharmacotherapy is safe and a promising treatment option.Jan 11, 2016

Adherence to the Mediterranean may positively affect not only the risk of AD, but also of predementia syndromes and their progression to overt dementia. May 01, 2011

Administration of saffron capsules was comparable with memantine in reducing cognitive decline in patients with moderate to severe AD.Jun 30, 2014

Aerobic exercise in early Alzheimer’s disease is associated with benefits in functional ability.Dec 31, 2016

Aerobic exercise sustains performance of instrumental activities of daily living in early-stage Alzheimer disease.Dec 27, 2017

Neurodegenerative Diseases

View the Evidence:
2719 Abstracts with Neurodegenerative Diseases Research