Osteoporosis

Name	AC	CK
Vitamin K2	19	116
Vitamin K	20	104
Vitamin D	19	97
Vitamin C	13	79
Isoflavones	7	64
Vitamin K2: Menaquinone-7	9	56
Magnesium	6	52
Soy	6	52
Natto	5	50
Plum	7	45
Genistein	9	41
Puerarin	10	37
Fruit: All	4	32
Vegetables: All	3	31
Vitamin K2: (MK-4)	4	31
Green Tea	7	28
Calcium	6	25
Citrus naringin	4	25
Hops	3	22
Strontium	3	21
phytoestrogens	3	21
Carotenoids	2	20
Red Clover	2	20
Berberine	6	18
Melatonin	5	17
Black Tea	4	16
Royal Jelly	4	15
Boron	4	14
Soy Protein	3	14
Cryptoxanthin	4	13
Curcumin	8	13
Fermented Foods and Beverages	2	12
Flavonoids	7	12
Lycopene	3	12
Probiotics	3	12
Beer	2	11
DHEA (Dehydroepiandrosterone)	2	11
Resveratrol	8	11
Black Cohosh	1	10
Brown Rice	1	10
Eicosapentaenoic acid (EPA)	1	10
Gamma-Linoleic Acid (GLA)	1	10
Japanese mugwort	1	10
Lactobacillus reuteri	1	10
Paprika	1	10
Silica: Orthosilicic acid	1	10
Vitamin B-5 (Pantothenic Acid)	1	10
Diosgenin	4	8
Pueraria mirifica	4	8
Zinc	5	8
Catechin	3	7
Ginsenosides	5	7
Myricetin	4	7
Onion	2	7
Tea	2	7
Emodin	3	6
Fucoidan	4	6
Gastrodin	3	6
Hesperidin	3	6
Kaempferol	3	6
Kudzu	3	6
Nigella sativa (aka Black Seed)	3	6
Polyphenols	4	6
Pomegranate	3	6
Xylitol	3	6
Asiatic Acid	3	5
Astragalus	1	5
EGCG (Epigallocatechin gallate)	3	5
Shikonin	3	5
Ursolic Acid	3	5
Vitamin E	3	5
Whey	3	5
Babchi	2	4
Black Raspberry	2	4
Blueberry	3	4
DHA (Docosahexaenoic Acid)	2	4
FOS (Fructooligosaccharides)	2	4
Kefir	2	4
Lactobacillus plantarum	2	4
NAC (N-acetyl-L-cysteine)	2	4
Nobiletin	2	4
Noni	2	4
Oleanolic acid	2	4
Olive Oil	2	4
Psychedelics:All	2	4
Safflower	2	4
Salvia miltiorrhiza	2	4
Chlorogenic Acid	2	3
Chrysanthemum Indicum	2	3
Coenzyme Q10	2	3
Isoquercitrin	2	3
Panax Notoginseng	2	3
Persimmon	2	3
Phloretin	2	3
Pomegranate Seed	2	3
Reishi Mushroom	2	3
Tanshinone IIA	2	3
Xanthohumol	2	3
18β-Glycyrrhetinic Acid	1	2
Adlay	1	2
Allicin	1	2
Alpha-Lipoic Acid	2	2
Antrodia camphorata	1	2
Arginine	1	2
Ashwagandha	1	2
Astaxanthin	1	2
Astragaloside	1	2
B-complex	2	2
Basil	1	2
Bergamot orange	1	2
Beta-Caryophyllene	1	2
Bifidobacterium Longum	1	2
Blackberry	1	2
Chia	1	2
Chicory	1	2
Clove	1	2
Coconut Oil	1	2
Cordyceps Militaris	1	2
Crocin	1	2
Cumin	1	2
Devils Claw	1	2
Dioscorea spongiosa	1	2
Equol	1	2
Fennel	1	2
Fenugreek	1	2
Ferulic acid	1	2
Fisetin	1	2
Formononetin	1	2
Garden Cress (Lepidium sativum)	1	2
Garlic	1	2
Grapefruit	1	2
Guava	1	2
Honeydew (melon)	1	2
Horsetail	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Kimchi	1	2
Krill	1	2
Lactoferrin	1	2
Lysine	1	2
Maca	1	2
Magnolol	1	2
Maitake Mushroom	1	2
Manganese	1	2
Milk Thistle	1	2
Milk: Fermented	1	2
Moringa oleifera	1	2
Mugwort	1	2
Mushrooms: All	1	2
Oleuropein	1	2
Olive	1	2
Orange	1	2
Oyster Mushroom	1	2
Paeoniflorin	1	2
Paeonol	1	2
Palash	1	2
Parsley	1	2
Passion Flower	1	2
Phellinus Linteus	1	2
Polygonatum Sibiricum	1	2
Prebiotics	2	2
Prickly Pear Cactus	1	2
Quercetin	1	2
Red Marine Algae	1	2
Red Yeast Rice	1	2
Rooibos	1	2
Rosemary	1	2
Sesamin	1	2
Shiitake Mushroom	1	2
Spinach	1	2
TA-65 (Astragalus compound)	1	2
Tangeretin	1	2
Tart Cherry	1	2
Theaflavins	1	2
Thyme	1	2
Thymoquinone	1	2
Tocotrienols	1	2
Tomatidine	2	2
Vitamin E: Gamma-tocotrienol	1	2
White Tea	1	2
Yacón	1	2
acetyl-11-keto-beta-boswellic acid	1	2
neohesperidin	1	2
Angelica	1	1
Anise	1	1
Anthocyanins	1	1
Artesunate	1	1
Avenanthramides	1	1
Bai Zhu	1	1
Baicalein	1	1
Barberry	1	1
Bergamot	1	1
Broccoli	1	1
Burdock	1	1
Cannabidiol	1	1
Chamomile	1	1
Chocolate	1	1
Cinnamon	1	1
Cocoa	1	1
Delphinidin	1	1
Epimedium	1	1
Fucoxanthin	1	1
Ginger	1	1
Ginseng (Korean)	1	1
Glycyrrhizin	1	1
Guduchi	1	1
Honeybush	1	1
Hydroxytyrosol	1	1
Icariin	1	1
Indole-3-Carbinol	1	1
Ligustrazine	1	1
Loquat	1	1
Lotus	1	1
Luteolin	1	1
Mangiferin	1	1
Maqui	1	1
Marijuana	1	1
Moxibustion	1	1
Nutmeg	1	1
Oats	1	1
Orange: Mandarin	1	1
Parthenolide	1	1
Piceatannol	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Progesterone	1	1
Prune	1	1
Prunella vulgaris	1	1
Punicalagin	1	1
Rehmannia	1	1
Seaweed	1	1
Seaweed: Brown	1	1
Sesamol	1	1
Sideritis	1	1
Sulforaphane	1	1
Thymol	1	1
Verbascoside	1	1
Vitamin A	1	1
Walnut	1	1
Water: Deep Sea	1	1
Zyflamend	1	1
Ipriflavone	1	0

Name	AC	CK
Bisphosphonates	10	48
Gluten	3	33
Warfarin	2	30
Alendronate (trade name Fosamax)	8	27
Rosiglitazone (trade name Avandia)	5	26
Proton-Pump Inhibitors	4	24
Arimidex	1	10
Aromatase Inhibitor Drugs	1	10
Aspirin	1	10
Bumex	1	10
Coffee	1	10
Diuretic Drugs	1	10
Diuretic: Loop	1	10
Histamine Receptor Antagonists	1	10
Letrozole (trade name Femera)	1	10
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	10
Tamoxifen	1	10
Dexamethasone	6	9
Risedronate	2	3
Aluminium Cans	1	2
Aluminum	1	2
Glyphosate	1	2
Retinoic Acid	1	2
Sugary soda	1	2
Zoledronic Acid	2	2
Aluminum Chloride	1	1
Cow Milk	2	1
Dioxins	1	1
Etidronate	1	1
Ibandronate	1	1
Pamidronate (trade name Aredia)	1	1
Thyroxine	1	1

Name	AC	CK
Tai Chi	5	60
Sunlight exposure	6	34
Exercise	5	33
Acupuncture	2	21
Yoga	2	20
Dietary Modification: Less Acid/More Alkaline Foods	1	10
Fasting/Caloric Restriction	1	10
Hyperbaric Treatment	1	10
Dietary Modification: Wheat/Gluten Free	2	4
Electroacupuncture	2	4
Laser Treatment: Low-Level	1	2
Whole-Body Vibration	2	2
Integrative Medicine	1	1

Name	AC	CK
High Bone Density	12	111
DXA Scans	3	21
Oophorectomy (Ovariectomy)	1	10
Western Diet	2	4

[+]

Greater dietary vitamin C intake was associated with a lower risk of hip fracture and osteoporosisMar 31, 2018

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2018 Apr ;119(8):847-858. PMID: 29644950

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6016874. Epub 2021 Feb 10. PMID: 33628301

Article Published Date : Dec 31, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Citrus naringin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Puerarin showed upregulating effects on bone mass in ovariectomy-induced postmenopausal osteoporosis.Jul 02, 2019

Click here to read the entire abstract

Pubmed Data : Curr Stem Cell Res Ther. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31269886

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2019 ;14(5):e0217223. Epub 2019 May 31. PMID: 31150426

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Fruit: All, Vegetables: All

Diseases : Fractures: Bone, Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Risk Reduction

[+]

This present systematic review indicated that acupuncture could be an effective therapy for treating osteoporosis.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2018 ;46(3):489-513. Epub 2018 Apr 4. PMID: 29614884

Click here to read the entire abstract

Pubmed Data : 1: Clin Ter. 2009 Mar-Apr;160(2):105-9. PMID:19452097

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Diseases : Osteoporosis

Therapeutic Actions : Exercise

[+]

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Click here to read the entire abstract

Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316

Click here to read the entire abstract

Pubmed Data : Cochrane Database Syst Rev. 2009(4):CD002010. Epub 2009 Oct 7. PMID: 19821288

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cystic Fibrosis, Osteoporosis

Problem Substances : Bisphosphonates

[+]

Bone mineral density is a significant prognostic factor for postmenopausal Caucasian women with breast cancer. Low bone mineral density is associated with a lower local and distant rate of recurrence.Feb 28, 2013

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Pubmed Data : Breast J. 2013 Mar-Apr;19(2):168-72. Epub 2013 Feb 13. PMID: 23406171

Click here to read the entire abstract

Pubmed Data : J Bone Miner Res. 2009 Jun;24(6):1086-94. PMID: 19138129

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Carotenoids, Lycopene

Diseases : Osteoporosis

[+]

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women.Aug 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Clin Nutr. 2017 Sep ;106(3):909-920. Epub 2017 Aug 2. PMID: 28768651

Article Published Date : Aug 31, 2017

Study Type : Human Study

Additional Links

Substances : Isoflavones, Probiotics, Red Clover

Diseases : Osteoporosis, Postmenopausal Disorders

Pharmacological Actions : Osteoprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Correcting Dysbiosis may help to correct malabsorption and resulting bone disease.May 01, 2001

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2001 May;46(5):1077-82. PMID: 11341652.PMID:11341652

Article Published Date : May 01, 2001

Study Type : Human Study

Additional Links

Diseases : Dysbiosis, Osteoporosis

[+]

DHEA supplementation improved lower extremity strength and function in older, frail women involved in a gentle exercise program of chair aerobics or yoga.Oct 25, 2008

Article Published Date : Oct 31, 1995

Study Type : Human Study

Additional Links

Substances : Green Tea

Diseases : Osteoporosis

[+]

DXA-generated Z-scores and T-scores may differ substantially and significantly in young adults.Oct 01, 2007

Click here to read the entire abstract

Pubmed Data : J Clin Densitom. 2007 Oct-Dec;10(4):351-8. Epub 2007 Jul 26. PMID: 17662630

Article Published Date : Oct 01, 2007

Study Type : Human Study

Additional Links

Diseases : Osteopenia, Osteoporosis

Additional Keywords : T-Score/Z-Score Mythology

Anti Therapeutic Actions : DXA Scans

[+]

Effects of ipriﬂavone on postmenopausal syndrome and osteoporosis. Jan 31, 2010

Click here to read the entire abstract

Pubmed Data : Gynecol Endocrinol. 2010 Feb ;26(2):76-80. PMID: 19672742

Click here to read the entire abstract

Pubmed Data : J Clin Orthop Trauma. 2019 Nov-Dec;10(6):1097-1100. Epub 2019 Mar 21. PMID: 31708635

Article Published Date : Oct 31, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Osteoporosis, Vitamin D Deficiency

Additional Keywords : Risk Factors

[+]

Higher bone density (upper 33%) is associated with a 2-fold increased risk of breast cancer.Mar 01, 2003

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Pubmed Data : Bone. 2003 Mar;32(3):211-6. PMID: 12667548

Article Published Date : Mar 01, 2003

Study Type : Human Study

Additional Links

Diseases : Breast Cancer, Osteoporosis

Additional Keywords : Diseases that are Linked

Anti Therapeutic Actions : High Bone Density

[+]

[+]

Isoflavones attenuate bone loss and have a potentially protective effect on the lumbar spine in womenFeb 01, 2004

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2004 Feb;79(2):326-33. PMID: 14749241

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Osteoporosis

[+]

Additional Keywords : Diseases that are Linked

[+]

Magnesium may have beneficial effects in reducing bone loss associated with high bone turnover, such as age-related osteoporosis. Dec 27, 2002

Click here to read the entire abstract

Pubmed Data : J Biol Chem. 2002 Dec 27;277(52):50341-7. Epub 2002 Oct 16. PMID: 9709941

Article Published Date : Dec 27, 2002

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Osteoporosis

[+]

Pubmed Data : J Pineal Res. 2015 Jun 3. Epub 2015 Jun 3. PMID: 26036434

Article Published Date : Jun 02, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Bone Fractures, Osteopenia, Osteoporosis

Pharmacological Actions : Osteogenic

Additional Keywords : Dose Response, Significant Treatment Outcome

[+]

Oophorectomy adversely affect healthy postmenopausal women by accelerating loss of bone mineral density (BMD) and the rate of increase in carotid artery intima-media thickness (CIMT).Mar 31, 2014

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Pubmed Data : Fertil Steril. 2014 Apr ;101(4):1117-22. Epub 2014 Feb 14. PMID: 24530156

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Nutr Res. 2020 ;64. Epub 2020 Oct 6. PMID: 33240029

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Carotenoids, Paprika

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Patients with Gaucher disease living in England have a high frequency of vitamin D deficiency Mar 01, 2009

Click here to read the entire abstract

Pubmed Data : Mol Genet Metab. 2009 Mar ;96(3):113-20. Epub 2009 Jan 14. PMID: 19147383

Click here to read the entire abstract

Pubmed Data : J Clin Gastroenterol. 2006 Nov-Dec;40(10):906-9. PMID: 17063109

Article Published Date : Oct 31, 2006

Study Type : Human Study

Additional Links

Diseases : Celiac Disease, Osteoporosis

Therapeutic Actions : Fasting/Caloric Restriction

Pharmacological Actions : Leptin Down-Regulation

Problem Substances : Gluten

[+]

Soy food consumption may reduce the risk of fracture in postmenopausal women, particularly among those in the early years following menopause.Sep 12, 2005

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2005 Sep 12;165(16):1890-5. PMID: 16157834

Article Published Date : Sep 12, 2005

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Bone Fractures, Osteoporosis

Additional Keywords : Risk Reduction

[+]

Click here to read the entire abstract

Pubmed Data : J Pediatr Endocrinol Metab. 1996 Mar;9 Suppl 1:101-11. PMID: 17921409

Article Published Date : Mar 01, 1996

Study Type : Human Study

Additional Links

Substances : Black Tea, Green Tea

Diseases : Hip Fracture, Osteopenia, Osteoporosis

[+]

The combination of β-cryptoxanthin and vitamin C is inversely associated with the risk of developing osteoporosis in post-menopausal Japanese female subjects.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2016 ;62(3):185-91. PMID: 27465725

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Cryptoxanthin, Vitamin C

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Risk Factors

[+]

The consumption of vitamin K2 rich fermented soybean food products may contribute to the relatively lower fracture risk of Japanese women. Apr 01, 2001

Click here to read the entire abstract

Pubmed Data : Nutrition. 2001 Apr;17(4):315-21. PMID: 11369171

Click here to read the entire abstract

Pubmed Data : Am J Physiol Renal Physiol. 2003 Jan;284(1):F32-40. Epub 2002 Sep 24. PMID: 12388390

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Diseases : Acid-Base Imbalance, Acidosis, Osteoporosis

Therapeutic Actions : Dietary Modification: Less Acid/More Alkaline Foods

[+]

These result shows that pantothenic acid rich diet can protect bone loss from estrogen deficiency.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2019 ;11(8):5008-5018. Epub 2019 Aug 15. PMID: 31497217

Article Published Date : Dec 31, 2018

[+]

Vitamin K2 treatment in combination with calcium supplementation increases bone mineral density in the treatment of postmenopausal osteoporosis.Apr 01, 2006

[+]

Yoga may be an alternative physical activity for the rehabilitation of osteoporotic subjects.Feb 18, 2010

Click here to read the entire abstract

Pubmed Data : Eur J Phys Rehabil Med. 2010 Feb 18. Epub 2010 Feb 18. PMID: 20332729

Article Published Date : Feb 18, 2010

Study Type : Human Study

Additional Links

Diseases : Osteoporosis

Therapeutic Actions : Yoga

[+]

Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells.Jan 01, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2019 ;13:1311-1321. Epub 2019 Apr 23. PMID: 31114166

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Osteoporos. 2011 Dec ;6(1-2):209-213. Epub 2011 Jun 15. PMID: 22207878

Article Published Date : Dec 01, 2011

Study Type : Human: Case Report

Additional Links

Substances : Calcium, Vitamin D

Diseases : Celiac Disease, Osteomalacia, Osteoporosis

Therapeutic Actions : Dietary Modification: Wheat/Gluten Free

Problem Substances : Gluten

[+]

High dose vitamin D may have a therapeutic role in certain cases of chronic pain associated with sickle cell anemia. Oct 01, 2011

Click here to read the entire abstract

Pubmed Data : J Pediatr Hematol Oncol. 2011 Oct ;33(7):549-51. PMID: 21941148

Article Published Date : Oct 01, 2011

Study Type : Human: Case Report

Additional Links

Substances : Vitamin D

Diseases : Osteoporosis, Sickle Cell Anemia, Vitamin D Deficiency

[+]

This case report describes a case of PPI-induced thrombocytopenia.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Case Rep Gastrointest Med. 2018 ;2018:4294805. Epub 2018 Apr 30. PMID: 29854491

Article Published Date : Dec 31, 2017

Study Type : Human: Case Report, Review

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Osteoporosis, Thrombocytopenia

Additional Keywords : Risk Factors

Problem Substances : Proton-Pump Inhibitors

[+]

[+]

2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside can be considered as a potential therapeutic for the treatment of postmenopausal osteoporosis.Aug 27, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2018 Aug 28 ;19(9). Epub 2018 Aug 28. PMID: 30154383

Article Published Date : Aug 27, 2018

Study Type : Animal Study

Additional Links

Diseases : Osteoporosis

Pharmacological Actions : Chondroprotective, Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:2617868. Epub 2016 Apr 10. PMID: 27143981

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Antrodia camphorata

Diseases : Osteoporosis

Pharmacological Actions : Osteogenic, Osteoprotective

Additional Keywords : Bone Regeneration, Plant Extracts

[+]

Aqueous extracts of parsley, basil and chicory showed bone protection against glucocorticoid-induced osteoporosis in rats.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):165. Epub 2016 Jun 2. PMID: 27255519

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Basil, Chicory, Parsley

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants, Bone Density Conservation Agents

Additional Keywords : Plant Extracts

[+]

Artemisia annua extract prevents ovariectomy-induced bone loss.Dec 10, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Calcif Tissue Int. 2019 Aug 21. Epub 2019 Aug 21. PMID: 31435709

Article Published Date : Aug 20, 2019

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Osteoporosis, Postmenopausal Disorders

Pharmacological Actions : Osteoprotective

[+]

Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis. Jun 17, 2020

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2020 Jun 18 ;527(1):270-275. Epub 2020 May 4. PMID: 32446379

Article Published Date : Jun 17, 2020

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Osteopenia, Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL‐induced osteoclastogenesis.Jan 11, 2019

Pubmed Data : Biomed Pharmacother. 2018 Sep 14 ;108:280-287. Epub 2018 Sep 14. PMID: 30223099

Article Published Date : Sep 13, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Diabetic Complications, Osteoporosis, Oxidative Stress

Pharmacological Actions : Antioxidants, Osteoprotective

[+]

Bergapten exerts inhibitory effects on diabetes-related osteoporosis.Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2016 Dec ;38(6):1661-1672. Epub 2016 Nov 2. PMID: 27840967

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Bergamot orange

Diseases : Diabetic Complications, Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective

[+]

Beta-caryophyllene may be used as a therapeutic agent for the prevention and treatment of osteoporosis.Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):3602-3606. Epub 2016 Oct 18. PMID: 28105093

Article Published Date : Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2016 ;21(2). Epub 2016 Jan 26. PMID: 26821009

Article Published Date : Dec 31, 2015

Pubmed Data : Life Sci. 2016 Dec 1 ;166:20-26. Epub 2016 Sep 30. PMID: 27697446

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Puerarin, Zinc

Diseases : Osteoporosis

Pharmacological Actions : Osteogenic, Osteoprotective

Additional Keywords : bone loss, Osteoporosis, Ovariectomy-Induced Changes, Puerarin, zinc

[+]

Connectivity map analysis identifies fisetin as a treatment compound for osteoporosis.Feb 28, 2021

Click here to read the entire abstract

Pubmed Data : Curr Pharm Biotechnol. 2021 Mar 1. Epub 2021 Mar 1. PMID: 33645479

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

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Consumption of vitamin D2 enhanced mushrooms is associated with improved bone health.Jun 30, 2015

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Pubmed Data : J Nutr Biochem. 2015 Jul ;26(7):696-703. Epub 2015 Mar 5. PMID: 25792284

Article Published Date : Jun 30, 2015

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Pubmed Data : J Food Biochem. 2019 Jul ;43(7):e12895. Epub 2019 May 15. PMID: 31353703

Article Published Date : Jun 30, 2019

Study Type : Animal Study

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Substances : Crocin

Diseases : Metabolic Syndrome X, Osteoporosis

Pharmacological Actions : Osteoprotective

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Cumambrin A prevents OVX-induced osteoporosis.Dec 31, 2018

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Pubmed Data : FASEB J. 2019 06 ;33(6):6726-6735. Epub 2019 Feb 26. PMID: 30807230

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Pubmed Data : Phytomedicine. 2011 Jan 15;18(2-3):205-13. Epub 2010 Jul 16. PMID: 20637579

Article Published Date : Jan 15, 2011

Study Type : Animal Study

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Substances : Curcumin

Diseases : Bone Fractures, Osteopenia, Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Curcumin may be a potential therapeutic agent for the treatment of glucocorticoid induced osteoporosis.Dec 10, 2015

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Pubmed Data : Int J Mol Med. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26677102

Article Published Date : Dec 10, 2015

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Pubmed Data : J Cell Physiol. 2008 Jan;214(1):201-9. PMID: 17929247

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : DHA (Docosahexaenoic Acid)

Diseases : Osteoporosis

[+]

Dietary cordycepin can prevent bone loss caused by estrogen deficiency.Dec 31, 2014

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Pubmed Data : Biomed Res Int. 2015 ;2015:423869. Epub 2015 Mar 22. PMID: 25874211

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cordyceps Militaris

Diseases : Osteoporosis, Oxidative Stress

Pharmacological Actions : Antioxidants, Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

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Dioscorea spongiosa has profound antiosteoporotic effects. Apr 01, 2004

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Pubmed Data : Biol Pharm Bull. 2004 Apr;27(4):583-6. PMID: 15056872

Article Published Date : Apr 01, 2004

Study Type : Animal Study

Additional Links

Substances : Dioscorea spongiosa

Diseases : Osteoporosis

[+]

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Pubmed Data : Calcif Tissue Int. 2012 Mar 21. Epub 2012 Mar 21. PMID: 22434366

Article Published Date : Mar 21, 2012

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Osteoporosis

Additional Keywords : Ovariectomy-Induced Changes

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EGCG reversed GIO in rats by protecting osteoblasts by activating the Nrf2 signaling pathway.Dec 31, 2017

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Pubmed Data : Food Funct. 2018 May 23. Epub 2018 May 23. PMID: 29790498

Article Published Date : May 22, 2018

Study Type : Animal Study

Additional Links

Substances : Rooibos

Diseases : Bone Diseases, Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective

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Genistein and equol positively effect bone quality and quantity in osteoporotic mice. Mar 01, 2002

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Pubmed Data : J Vet Med Sci. 2002 Mar;64(3):227-35. PMID: 20036112

Article Published Date : Mar 01, 2002

Study Type : Animal Study

Additional Links

Substances : Equol, Genistein

Diseases : Osteoporosis

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Genistein is superior to the bone drugs alendronate, raloxifene and estradiol in osteoporotic, ovariectomized rats. Nov 01, 2008

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Pubmed Data : Nutr Res. 2015 Dec ;35(12):1095-105. Epub 2015 Oct 5. PMID: 26525915

Article Published Date : Dec 01, 2015

Study Type : Animal Study

Additional Links

Substances : Polyphenols

Diseases : Adiponectin: Low Levels, Female, Obesity, Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Harmine enhances type H vessel formation and prevents bone loss in ovariectomized mice.Dec 31, 2017

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Pubmed Data : J Appl Physiol. 2008 Mar;104(3):648-54. Epub 2008 Jan 3. PMID: 18174393

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Osteoporosis

Additional Keywords : Bone Quality

[+]

High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio.Sep 24, 2014

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Pubmed Data : Int J Mol Sci. 2014 Sep 25 ;15(9):17130-47. Epub 2014 Sep 25. PMID: 25257532

Article Published Date : Sep 24, 2014

Study Type : Animal Study

Additional Links

Substances : Diosgenin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Hu Zhang (resveratrol) has positive effect on bone loss in the ovariectomized rat model. Mar 01, 2005

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Pubmed Data : J Med Food. 2005 Spring;8(1):14-9. PMID: 15857203

Article Published Date : Mar 01, 2005

Study Type : Animal Study

Additional Links

Substances : Hu Zhang (Polygonum cuspidatum), Resveratrol

Diseases : Osteoporosis

[+]

Humulus lupulus L. extract may protect against bone loss, and have potentials in the treatment of osteoporosis.Mar 26, 2019

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Pubmed Data : Chin J Integr Med. 2019 Mar 27. Epub 2019 Mar 27. PMID: 30919241

Article Published Date : Mar 26, 2019

Study Type : Animal Study

Additional Links

Substances : Hops

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Inhibition of osteoclastogenesis and bone resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops.Nov 30, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Osteoporos Int. 2015 Feb ;26(2):589-99. Epub 2014 Oct 3. PMID: 25278298

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Kefir, Milk: Fermented

Diseases : Osteoporosis

Pharmacological Actions : Osteogenic

Additional Keywords : Significant Treatment Outcome

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Kefir-fermented peptides prevent menopausal osteoporosis and mildly modulate the structure of the gut microbiota.Nov 08, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Nov 9 ;12(11). Epub 2020 Nov 9. PMID: 33182364

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Jul 13 ;12(7). Epub 2020 Jul 13. PMID: 32668691

Article Published Date : Jul 12, 2020

Study Type : Animal Study

Additional Links

Substances : Garden Cress (Lepidium sativum)

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

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Low‑molecular weight fucoidan inhibits the differentiation of osteoclasts and reduces osteoporosis in ovariectomized rats.Jan 31, 2017

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Pubmed Data : Mol Med Rep. 2017 Feb ;15(2):890-898. Epub 2016 Dec 20. PMID: 28000877

Article Published Date : Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2019 Feb 18. Epub 2019 Feb 18. PMID: 30816431

Article Published Date : Feb 17, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Magnolol

Diseases : Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Manganese supplementation improves mineral density in rats. Jul 01, 2008

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Pubmed Data : Biol Trace Elem Res. 2008 Jul;124(1):28-34. Epub 2008 Mar 11. PMID: 18330520

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Manganese

Diseases : Osteoporosis

[+]

Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells.Oct 23, 2019

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Pubmed Data : Free Radic Biol Med. 2019 Oct 24. Epub 2019 Oct 24. PMID: 31669348

Article Published Date : Oct 23, 2019

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants

Additional Keywords : Mesenchymal Stem Cells

[+]

Melatonin treatment is an efficient and practical strategy to improve in vitro expansion of BMMSCs for tissue engineering and cytotherapy.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Theranostics. 2016 ;6(11):1899-917. Epub 2016 Aug 8. PMID: 27570559

Article Published Date : Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Exp Ther Med. 2016 May ;11(5):1881-1888. Epub 2016 Mar 10. PMID: 27168821

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Olive Oil

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Olive oil prevents bone loss in tumor patients and has excellent prospects for curing osteoporosis after menopause.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Interv Aging. 2014 ;9:2087-95. Epub 2014 Dec 2. PMID: 25506212

Pubmed Data : Pharmacol Rep. 2017 Oct ;69(5):1113-1119. Epub 2017 May 13. PMID: 29031689

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Kaempferol

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Oral administration of quercetin or its derivatives inhibit bone loss in animal model of osteoporosis.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Cell Endocrinol. 2015 Dec 5 ;417:103-13. Epub 2015 Sep 28. PMID: 26419930

Article Published Date : Dec 04, 2015

Study Type : Animal Study

Additional Links

Substances : Babchi

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts

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View the Evidence: 526 Abstracts with Osteoporosis Research

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Greater dietary vitamin C intake was associated with a lower risk of hip fracture and osteoporosisMar 31, 2018

High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women.Apr 01, 2009

Long-term use of warfarin was associated with osteoporotic fractures, at least in men with atrial fibrillation. Jan 23, 2006

Low serum level of magnesium seems to be a risk factor for osteoporosis among the postmenopausal women.May 31, 2014

Naringin had been shown to promote bone formation in OVX rats. Dec 31, 2020

Puerarin showed upregulating effects on bone mass in ovariectomy-induced postmenopausal osteoporosis.Jul 02, 2019

Soy isoflavones prevent bone resorption and loss.Jul 09, 2019

Tai chi is effective in improving balance of older adults and in the absence of other interventions, reduces falls in the nonfrail elderly.Jan 01, 2011

The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis.Dec 31, 2019

There was an association between the increase of at least one serving of fruits and vegetables per day and decreases in the risk of fractures.Dec 31, 2018

This present systematic review indicated that acupuncture could be an effective therapy for treating osteoporosis.Dec 31, 2017

Vitamin K1 and K2 exhibit anti-fracture activity.Dec 01, 2009

A black cohosh extract is equipotent to conjugated estrogens in reducing menopausal symptoms and bone markers, without adverse effects. Mar 14, 2003

A specific exercise program targeting osteoporosis improves the condition of postmenopausal women with low bone density. Mar 01, 2009

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Alendronate use is associated with low-energy femoral shaft fractures. May 01, 2008

Although hip bone mineral density is strongly related to hip fracture risk in elderly white women, other clinical risk factors also are independent predictors of long-term risk.Sep 01, 2004

Ambient air pollution was associated with lower bone mineral content in a young adult population in a peri-urban area of South India.Jan 02, 2020

Arimidex therapy contributes in the decline of bone mineral density in early breast cancer patients.Jan 01, 2010

Artemisia princeps as a promising therapeutic option for the improvement of postmenopausal osteoporosis.Dec 31, 2015

Ascorbic acid may modify the composition of gut microbiota which plays a role in the pathogenesis of an inflammatory bowel disease.Jul 28, 2020

Beer drinking contributes to higher bone density as a result of the phytoestrogen content (hops) of this alcoholic beverage. Oct 01, 2009

Bisphosphonate use in chronic kidney disease is associated wtih adynamic bone disease.Jan 01, 2010

Bisphosphonates used for osteoporosis in patients with cystic fibrosis increases bone mineral density without increasing bone quality/strength, while causing bone pain and flu-like symptoms. Jan 01, 2009

Bone mineral density is a significant prognostic factor for postmenopausal Caucasian women with breast cancer. Low bone mineral density is associated with a lower local and distant rate of recurrence.Feb 28, 2013

Calcium supplementation (without vitamin D) is associated with increased risk of bone fracture.Aug 01, 2008

Calcium supplementation may actually increase the risk of bone fracture.Dec 01, 2007

Carotenoids such as lycopene have a protective effect on bone health.Jun 01, 2009

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women.Aug 31, 2017

Correcting Dysbiosis may help to correct malabsorption and resulting bone disease.May 01, 2001

DHEA supplementation improved lower extremity strength and function in older, frail women involved in a gentle exercise program of chair aerobics or yoga.Oct 25, 2008

Dietary magnesium may play a role in musculoskeletal health.Oct 29, 2017

Dietary vitamin K2 supplement improves bone status after lung and heart transplantation.Feb 27, 2010

Dried plum improves bone mineral density in postmenopausal women. May 31, 2011

Dried plum in its whole form is a promising and efficacious functional food therapy for preventing bone loss in postmenopausal women.May 13, 2017

Dried plums improve indices of bone formation in postmenopausal women.Mar 01, 2010

Drinking up to 3 cups of tea per day was associated with a 30% reduction in the risk of hip fractures in women.Oct 31, 1995

DXA-generated Z-scores and T-scores may differ substantially and significantly in young adults.Oct 01, 2007

Effects of ipriﬂavone on postmenopausal syndrome and osteoporosis. Jan 31, 2010

Elderly women with high bone mineral density (BMD) have up to 2.7 times greater risk of breast cancer, especially advanced cancer, compared with women with low BMD.Jun 20, 2001

Gamma-linolenic acid (GLA) and Eicosapentaenoic acid (EPA) have beneficial effects on bone in elderly patients. Oct 01, 1998

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.Oct 01, 2002

Genistein has a positive effect on bone metabolism in osteopenic postmenopausal women, without increasing endometrial thickness. Jun 19, 2007

Genistein is safe and effective in improving bone density without adverse responses in breast density or endometrium thickness in osteopenic, postmenopausal women. Dec 01, 2008

Green and yellow vegetable consumption is effective for maintaining bone mass in young women. Jan 01, 2009

Group exercise has a positive effect on postmenopausal osteoporosis and osteopenia.Aug 01, 2009

High consumption of coffee seems to contribute to a reduction in BMD Dec 31, 2009

High prevalence of vitamin D deficiency and osteoporosis in patients with fragility fractures of hip.Oct 31, 2019

Higher bone density (upper 33%) is associated with a 2-fold increased risk of breast cancer.Mar 01, 2003

Higher bone mass is associated with greater risk for breast cancer.Mar 20, 2007

Higher bone mineral density is associated with higher incidence of estrogen receptor positive breast cancer.Jul 20, 2007

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women. Dec 19, 2009

In a healthy middle aged population with normal BMD, an increase in plant food consumption, either alone or in combination with a diet containing meat, is associated with improved bone mineralisation markers.Jan 01, 2020

Increase in lumbar spine and femoral neck bone mineral density is associated with a 2.1 fold and 1.5 fold respectively, higher risk of breast cancer.Jul 31, 2000

Intake of fermented soybean (natto) increases circulating vitamin K2 and osteocalcin (a marker for bone formation) in normal individuals. Jan 01, 2000

Isoflavones attenuate bone loss and have a potentially protective effect on the lumbar spine in womenFeb 01, 2004

Lactobacillus reuteri reduces bone loss in older women with low bone mineral density.Jun 20, 2018

Long term use of vitamin C supplements was associated with a higher BMD in the early postmenopausal years and among never users of oestrogen.Sep 30, 1997

Long-term proton pump inhibitor therapy is associated with an increased risk of hip fracture.Dec 27, 2006

Long-term proton pump inhibitors use is associated with risk of bone complications.Feb 28, 2018

Long-term ultra-high hydrostatic pressurized brown rice intake prevents bone mineral density decline in elderly Japanese individuals.Dec 31, 2018

Long-term use of bisphosphonates is assocated with low-energy femoral fractures. Jan 01, 2009

Low levels of serum ascorbic acid in elderly patients with hip fracture.Apr 30, 1998

Magnesium deficiency may contribute to osteoporosis promotion associated with gluten-sensitive enteropathy.Jan 01, 1996

Magnesium may have beneficial effects in reducing bone loss associated with high bone turnover, such as age-related osteoporosis. Dec 27, 2002

Mammographic breast density is inversely associated with bone mineral density in the perimenopausal women.Aug 01, 2007

Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis.Dec 31, 2019

Menaquinone-7 (vitamin K2) supplementation increases osteocalcin carboxylation associated with improved bone quality.Oct 01, 2009

MK-7 in addition to ordinary meals could improve osteocalcin γ-carboxylation status.Dec 31, 2014

More than 10,000 steps daily may be needed to maintain bone mineral density.Dec 01, 2011

Most of the increase in mortality following hip and pelvic fractures is due to underlying conditions and probably would not be affected by reductions in the incidence of these fractures.Jul 22, 1996

Multiple hyperbaric oxygen treatments has the possibility of contributing to recovery acceleration in patients with transient osteoporosis of the hip.Oct 31, 2016

Osteoporosis

View the Evidence:
526 Abstracts with Osteoporosis Research