Osteoporosis

Name	AC	CK
Vitamin K2	18	106
Vitamin K	19	103
Vitamin D	14	82
Vitamin C	11	68
Vitamin K2: Menaquinone-7	9	56
Soy	6	52
Magnesium	5	50
Natto	5	50
Plum	7	45
Genistein	9	41
Isoflavones	4	32
Calcium	6	25
Green Tea	5	25
Hops	3	22
Strontium	3	21
Vitamin K2: (MK-4)	3	21
phytoestrogens	3	21
Berberine	6	18
Black Tea	4	16
Boron	4	14
Soy Protein	3	14
Cryptoxanthin	4	13
Puerarin	7	13
Curcumin	7	12
Fruit: All	3	12
Melatonin	2	12
DHEA (Dehydroepiandrosterone)	2	11
Vegetables: All	2	11
Beer	1	10
Black Cohosh	1	10
Carotenoids	1	10
Eicosapentaenoic acid (EPA)	1	10
Fermented Foods and Beverages	1	10
Gamma-Linoleic Acid (GLA)	1	10
Lactobacillus reuteri	1	10
Lycopene	1	10
Red Clover	1	10
Resveratrol	7	10
Silica: Orthosilicic acid	1	10
Diosgenin	4	8
Pueraria mirifica	4	8
Onion	2	7
Gastrodin	3	6
Hesperidin	3	6
Nigella sativa (aka Black Seed)	3	6
Pomegranate	3	6
Xylitol	3	6
Zinc	4	6
Citrus naringin	3	5
Fucoidan	3	5
Myricetin	3	5
Vitamin E	3	5
Black Raspberry	2	4
DHA (Docosahexaenoic Acid)	2	4
EGCG (Epigallocatechin gallate)	2	4
Emodin	2	4
FOS (Fructooligosaccharides)	2	4
Ginsenosides	3	4
Kudzu	2	4
Noni	2	4
Oleanolic acid	2	4
Olive Oil	2	4
Psychedelics:All	2	4
Royal Jelly	2	4
Chlorogenic Acid	2	3
Flavonoids	2	3
Phloretin	2	3
Pomegranate Seed	2	3
Tanshinone IIA	2	3
Ursolic Acid	2	3
Whey	2	3
Xanthohumol	2	3
18β-Glycyrrhetinic Acid	1	2
Adlay	1	2
Alpha-Lipoic Acid	2	2
Antrodia camphorata	1	2
Arginine	1	2
Ashwagandha	1	2
B-complex	2	2
Basil	1	2
Bergamot orange	1	2
Beta-Caryophyllene	1	2
Blackberry	1	2
Blueberry	1	2
Chicory	1	2
Clove	1	2
Coconut Oil	1	2
Coenzyme Q10	1	2
Cordyceps Militaris	1	2
Cumin	1	2
Devils Claw	1	2
Dioscorea spongiosa	1	2
Equol	1	2
Fennel	1	2
Fenugreek	1	2
Grapefruit	1	2
Horsetail	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Kefir	1	2
Lactoferrin	1	2
Lysine	1	2
Maca	1	2
Magnolol	1	2
Maitake Mushroom	1	2
Manganese	1	2
Milk Thistle	1	2
Milk: Fermented	1	2
Mugwort	1	2
Mushrooms: All	1	2
Nobiletin	1	2
Oleuropein	1	2
Olive	1	2
Orange	1	2
Oyster Mushroom	1	2
Paeoniflorin	1	2
Palash	1	2
Parsley	1	2
Passion Flower	1	2
Phellinus Linteus	1	2
Polygonatum Sibiricum	1	2
Polyphenols	1	2
Prebiotics	2	2
Prickly Pear Cactus	1	2
Probiotics	2	2
Red Marine Algae	1	2
Red Yeast Rice	1	2
Rooibos	1	2
Rosemary	1	2
Safflower	1	2
Shiitake Mushroom	1	2
Spinach	1	2
TA-65 (Astragalus compound)	1	2
Tangeretin	1	2
Tart Cherry	1	2
Tea	1	2
Thyme	1	2
Thymoquinone	1	2
Tocotrienols	1	2
Vitamin E: Gamma-tocotrienol	1	2
Yacón	1	2
neohesperidin	1	2
Anise	1	1
Asiatic Acid	1	1
Avenanthramides	1	1
Bai Zhu	1	1
Baicalein	1	1
Barberry	1	1
Cannabidiol	1	1
Catechin	1	1
Chamomile	1	1
Chrysanthemum Indicum	1	1
Cinnamon	1	1
Epimedium	1	1
Glycyrrhizin	1	1
Honeybush	1	1
Hydroxytyrosol	1	1
Icariin	1	1
Indole-3-Carbinol	1	1
Isoquercitrin	1	1
Ligustrazine	1	1
Loquat	1	1
Luteolin	1	1
Mangiferin	1	1
Marijuana	1	1
Nutmeg	1	1
Oats	1	1
Panax Notoginseng	1	1
Parthenolide	1	1
Persimmon	1	1
Progesterone	1	1
Prune	1	1
Rehmannia	1	1
Sesamol	1	1
Sideritis	1	1
Thymol	1	1
Tomatidine	1	1
Verbascoside	1	1
Vitamin A	1	1
Walnut	1	1
Water: Deep Sea	1	1
Zyflamend	1	1
Ipriflavone	1	0

Name	AC	CK
Bisphosphonates	10	48
Gluten	3	33
Warfarin	2	30
Alendronate (trade name Fosamax)	8	27
Rosiglitazone (trade name Avandia)	5	26
Proton-Pump Inhibitors	4	24
Arimidex	1	10
Aromatase Inhibitor Drugs	1	10
Aspirin	1	10
Bumex	1	10
Coffee	1	10
Diuretic Drugs	1	10
Diuretic: Loop	1	10
Histamine Receptor Antagonists	1	10
Letrozole (trade name Femera)	1	10
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	10
Tamoxifen	1	10
Dexamethasone	6	9
Risedronate	2	3
Aluminium Cans	1	2
Sugary soda	1	2
Zoledronic Acid	2	2
Aluminum Chloride	1	1
Cow Milk	2	1
Etidronate	1	1
Ibandronate	1	1
Pamidronate (trade name Aredia)	1	1
Thyroxine	1	1

Name	AC	CK
Tai Chi	5	60
Sunlight exposure	4	32
Acupuncture	1	20
Exercise	2	20
Yoga	2	20
Dietary Modification: Less Acid/More Alkaline Foods	1	10
Fasting/Caloric Restriction	1	10
Hyperbaric Treatment	1	10
Dietary Modification: Wheat/Gluten Free	2	4
Electroacupuncture	2	4
Laser Treatment: Low-Level	1	2
Whole-Body Vibration	2	2
Integrative Medicine	1	1

Name	AC	CK
High Bone Density	12	111
DXA Scans	3	21
Oophorectomy (Ovariectomy)	1	10
Western Diet	2	4

[+]

Greater dietary vitamin C intake was associated with a lower risk of hip fracture and osteoporosisMar 31, 2018

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Pubmed Data : Br J Nutr. 2018 Apr ;119(8):847-858. PMID: 29644950

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Pubmed Data : Curr Stem Cell Res Ther. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31269886

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2019 ;14(5):e0217223. Epub 2019 May 31. PMID: 31150426

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Fruit: All, Vegetables: All

Diseases : Fractures: Bone, Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Risk Reduction

[+]

This present systematic review indicated that acupuncture could be an effective therapy for treating osteoporosis.Dec 31, 2017

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Pubmed Data : Am J Chin Med. 2018 ;46(3):489-513. Epub 2018 Apr 4. PMID: 29614884

Click here to read the entire abstract

Pubmed Data : 1: Clin Ter. 2009 Mar-Apr;160(2):105-9. PMID:19452097

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Diseases : Osteoporosis

Therapeutic Actions : Exercise

[+]

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

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Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316

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Pubmed Data : Nutrition. 2009 Oct;25(10):1057-63. Epub 2009 Jun 13. PMID: 19527924

Article Published Date : Oct 01, 2009

Study Type : Human Study

Additional Links

Substances : Beer, Hops, phytoestrogens

Diseases : Osteoporosis

[+]

Bisphosphonate use in chronic kidney disease is associated wtih adynamic bone disease.Jan 01, 2010

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Pubmed Data : Blood Purif. 2010;29(3):293-9. Epub 2010 Jan 21. PMID: 20090316

Pubmed Data : Osteoporos Int. 2008 Aug;19(8):1119-23. Epub 2008 Feb 20. PMID: 18286218

Article Published Date : Aug 01, 2008

Study Type : Human Study

Additional Links

Diseases : Bone Fractures, Osteoporosis

[+]

Problem Substances : Cell Phone Exposure

[+]

Gamma-linolenic acid (GLA) and Eicosapentaenoic acid (EPA) have beneficial effects on bone in elderly patients. Oct 01, 1998

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Pubmed Data : Aging (Milano). 1998 Oct;10(5):385-94. PMID: 9932142

Article Published Date : Oct 01, 1998

Study Type : Human Study

Additional Links

Substances : Eicosapentaenoic acid (EPA) , Gamma-Linoleic Acid (GLA)

Diseases : Osteoporosis

[+]

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.Oct 01, 2002

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Pubmed Data : J Bone Miner Res. 2002 Oct;17(10):1904-12. PMID: 12369794

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Pubmed Data : Bone. 2003 Mar;32(3):211-6. PMID: 12667548

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Pubmed Data : J Bone Miner Metab. 2000;18(4):216-22. PMID: 10874601

Article Published Date : Jan 01, 2000

Study Type : Human Study

Additional Links

Substances : Natto , Vitamin K

Diseases : Osteoporosis

Pharmacological Actions : Secretagogue

[+]

Isoflavones attenuate bone loss and have a potentially protective effect on the lumbar spine in womenFeb 01, 2004

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Pubmed Data : Am J Clin Nutr. 2004 Feb;79(2):326-33. PMID: 14749241

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Osteoporosis

[+]

Click here to read the entire abstract

Pubmed Data : Scand J Clin Lab Invest. 1998 May ;58(3):225-8. PMID: 9670346

Article Published Date : Apr 30, 1998

Study Type : Human Study

Additional Links

Substances : Vitamin C

Diseases : Hip Fracture, Osteoporosis

[+]

Magnesium deficiency may contribute to osteoporosis promotion associated with gluten-sensitive enteropathy.Jan 01, 1996

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Pubmed Data : Osteoporos Int. 1996;6(6):453-61. PMID: 9116391

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Pubmed Data : Br J Nutr. 2009 Oct;102(8):1171-8. Epub 2009 May 19. PMID: 19450370

Article Published Date : Oct 01, 2009

Study Type : Human Study

Additional Links

Substances : Vitamin K2: Menaquinone-7

Diseases : Bone Fractures, Osteoporosis

[+]

MK-7 in addition to ordinary meals could improve osteocalcin γ-carboxylation status.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2015 ;61(6):471-80. PMID: 26875489

Pubmed Data : J Pineal Res. 2015 Jun 3. Epub 2015 Jun 3. PMID: 26036434

Article Published Date : Jun 02, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Bone Fractures, Osteopenia, Osteoporosis

Pharmacological Actions : Osteogenic

Additional Keywords : Dose Response, Significant Treatment Outcome

[+]

Oophorectomy adversely affect healthy postmenopausal women by accelerating loss of bone mineral density (BMD) and the rate of increase in carotid artery intima-media thickness (CIMT).Mar 31, 2014

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Pubmed Data : Fertil Steril. 2014 Apr ;101(4):1117-22. Epub 2014 Feb 14. PMID: 24530156

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Pubmed Data : Mol Genet Metab. 2009 Mar ;96(3):113-20. Epub 2009 Jan 14. PMID: 19147383

Pubmed Data : J Clin Gastroenterol. 2006 Nov-Dec;40(10):906-9. PMID: 17063109

Article Published Date : Oct 31, 2006

Study Type : Human Study

Additional Links

Diseases : Celiac Disease, Osteoporosis

Therapeutic Actions : Fasting/Caloric Restriction

Pharmacological Actions : Leptin Down-Regulation

Problem Substances : Gluten

[+]

Soy food consumption may reduce the risk of fracture in postmenopausal women, particularly among those in the early years following menopause.Sep 12, 2005

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Pubmed Data : Arch Intern Med. 2005 Sep 12;165(16):1890-5. PMID: 16157834

Article Published Date : Sep 12, 2005

Study Type : Human Study

Additional Links

Substances : Soy

Diseases : Bone Fractures, Osteoporosis

Additional Keywords : Risk Reduction

[+]

Click here to read the entire abstract

Pubmed Data : J Pediatr Endocrinol Metab. 1996 Mar;9 Suppl 1:101-11. PMID: 17921409

Article Published Date : Mar 01, 1996

Study Type : Human Study

Additional Links

Substances : Black Tea, Green Tea

Diseases : Hip Fracture, Osteopenia, Osteoporosis

[+]

The combination of β-cryptoxanthin and vitamin C is inversely associated with the risk of developing osteoporosis in post-menopausal Japanese female subjects.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2016 ;62(3):185-91. PMID: 27465725

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Cryptoxanthin, Vitamin C

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Risk Factors

[+]

The consumption of vitamin K2 rich fermented soybean food products may contribute to the relatively lower fracture risk of Japanese women. Apr 01, 2001

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Pubmed Data : Nutrition. 2001 Apr;17(4):315-21. PMID: 11369171

[+]

Yoga may be an alternative physical activity for the rehabilitation of osteoporotic subjects.Feb 18, 2010

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Pubmed Data : Eur J Phys Rehabil Med. 2010 Feb 18. Epub 2010 Feb 18. PMID: 20332729

Article Published Date : Feb 18, 2010

Study Type : Human Study

Additional Links

Diseases : Osteoporosis

Therapeutic Actions : Yoga

[+]

Onion juice consumption showed a positive modulatory effect on the bone loss and bone mineral density.Feb 16, 2016

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Pubmed Data : Food Funct. 2016 Feb 17 ;7(2):902-12. PMID: 26686359

Article Published Date : Feb 16, 2016

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Onion

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants

[+]

The results of the present study suggested that vitamin K2 targets miR-133a to regulate osteogenesis.Apr 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2017 May ;15(5):2473-2480. Epub 2017 Mar 9. PMID: 28447758

Article Published Date : Apr 30, 2017

Study Type : Human In Vitro

Additional Links

Substances : Vitamin K2

Diseases : Osteonecrosis, Osteoporosis

Pharmacological Actions : MicroRNA modulator, Osteogenic

[+]

Calcium, Vitamin D and a Gluten-Free diet decreased bone pain and improved muscle strength.Dec 01, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Osteoporos. 2011 Dec ;6(1-2):209-213. Epub 2011 Jun 15. PMID: 22207878

Article Published Date : Dec 01, 2011

Study Type : Human: Case Report

Additional Links

Substances : Calcium, Vitamin D

Diseases : Celiac Disease, Osteomalacia, Osteoporosis

Therapeutic Actions : Dietary Modification: Wheat/Gluten Free

Problem Substances : Gluten

[+]

High dose vitamin D may have a therapeutic role in certain cases of chronic pain associated with sickle cell anemia. Oct 01, 2011

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Pubmed Data : J Pediatr Hematol Oncol. 2011 Oct ;33(7):549-51. PMID: 21941148

Article Published Date : Oct 01, 2011

Study Type : Human: Case Report

Additional Links

Substances : Vitamin D

Diseases : Osteoporosis, Sickle Cell Anemia, Vitamin D Deficiency

[+]

This case report describes a case of PPI-induced thrombocytopenia.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Case Rep Gastrointest Med. 2018 ;2018:4294805. Epub 2018 Apr 30. PMID: 29854491

Article Published Date : Dec 31, 2017

Study Type : Human: Case Report, Review

Additional Links

Diseases : Drug-Induced Nutrient Depletion: Vitamin B-12, Osteoporosis, Thrombocytopenia

Additional Keywords : Risk Factors

Problem Substances : Proton-Pump Inhibitors

[+]

"Clove (Syzygium aromaticum Linn) extract rich in eugenol and eugenol derivatives shows bone-preserving efficacy."Mar 01, 2012

Additional Keywords : Ovariectomy-Induced Changes

[+]

Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis.Apr 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Pharmacol. 2016 May-Jun;48(3):312-5. PMID: 27298503

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Horsetail

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Natural Substances Versus Drugs

[+]

Analysis of anti-osteoporosis function of chlorogenic acid by gene microarray profiling in ovariectomy rat model.Jan 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):165. Epub 2016 Jun 2. PMID: 27255519

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Basil, Chicory, Parsley

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants, Bone Density Conservation Agents

Additional Keywords : Plant Extracts

[+]

Artemisia annua extract prevents ovariectomy-induced bone loss.Dec 10, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Beta-caryophyllene may be used as a therapeutic agent for the prevention and treatment of osteoporosis.Nov 30, 2016

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Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):3602-3606. Epub 2016 Oct 18. PMID: 28105093

Article Published Date : Nov 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2016 ;21(2). Epub 2016 Jan 26. PMID: 26821009

Article Published Date : Dec 31, 2015

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Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2006 Dec;26(12):1785-8. PMID: 17259120

Article Published Date : Dec 01, 2006

Study Type : Animal Study

Additional Links

Substances : Boron

Diseases : Osteoporosis

[+]

Citrus juice positively affects serum antioxidant status and bone strength.May 01, 2006

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Pubmed Data : Nutrition. 2006 May;22(5):559-63. Epub 2006 Feb 10. PMID: 16472977

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants

[+]

Co-administrated puerarin and zinc can partially reverse OVX-induced bone loss.Nov 30, 2016

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Pubmed Data : Life Sci. 2016 Dec 1 ;166:20-26. Epub 2016 Sep 30. PMID: 27697446

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Puerarin, Zinc

Diseases : Osteoporosis

Pharmacological Actions : Osteogenic, Osteoprotective

Additional Keywords : bone loss, Osteoporosis, Ovariectomy-Induced Changes, Puerarin, zinc

[+]

Consumption of vitamin D2 enhanced mushrooms is associated with improved bone health.Jun 30, 2015

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Pubmed Data : J Nutr Biochem. 2015 Jul ;26(7):696-703. Epub 2015 Mar 5. PMID: 25792284

Article Published Date : Jun 30, 2015

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Pubmed Data : Phytomedicine. 2011 Jan 15;18(2-3):205-13. Epub 2010 Jul 16. PMID: 20637579

Article Published Date : Jan 15, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Bone Fractures, Osteopenia, Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin may be a potential therapeutic agent for the treatment of glucocorticoid induced osteoporosis.Dec 10, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26677102

Article Published Date : Dec 10, 2015

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Pubmed Data : J Cell Physiol. 2008 Jan;214(1):201-9. PMID: 17929247

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : DHA (Docosahexaenoic Acid)

Diseases : Osteoporosis

[+]

Dietary cordycepin can prevent bone loss caused by estrogen deficiency.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2015 ;2015:423869. Epub 2015 Mar 22. PMID: 25874211

Article Published Date : Dec 31, 2014

[+]

Gastrodin was able to prevent or delay dexamethasone induced osteoporosis.Mar 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2018 Apr ;41(4):2059-2069. Epub 2018 Jan 23. PMID: 29393365

Article Published Date : Mar 31, 2018

Study Type : Animal Study

Additional Links

Substances : Gastrodin

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants, Nrf2 activation, Osteoprotective

Problem Substances : Dexamethasone

[+]

Genistein and equol positively effect bone quality and quantity in osteoporotic mice. Mar 01, 2002

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Pubmed Data : J Vet Med Sci. 2002 Mar;64(3):227-35. PMID: 20036112

Article Published Date : Mar 01, 2002

Study Type : Animal Study

Additional Links

Substances : Equol, Genistein

Diseases : Osteoporosis

[+]

Genistein is superior to the bone drugs alendronate, raloxifene and estradiol in osteoporotic, ovariectomized rats. Nov 01, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Pharmacol. 2008 Nov;155(6):896-905. Epub 2008 Aug 11. PMID: 18695641

Article Published Date : Nov 01, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Bone Fractures, Osteopenia, Osteoporosis

Additional Keywords : Ovariectomy-Induced Changes, Superiority of Natural Substances versus Drugs

[+]

Pubmed Data : J Appl Physiol. 2008 Mar;104(3):648-54. Epub 2008 Jan 3. PMID: 18174393

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Osteoporosis

Additional Keywords : Bone Quality

[+]

High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio.Sep 24, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2014 Sep 25 ;15(9):17130-47. Epub 2014 Sep 25. PMID: 25257532

Article Published Date : Sep 24, 2014

Study Type : Animal Study

Additional Links

Substances : Diosgenin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Hu Zhang (resveratrol) has positive effect on bone loss in the ovariectomized rat model. Mar 01, 2005

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Pubmed Data : Animal Model Exp Med. 2019 Mar ;2(1):51-57. Epub 2019 Feb 21. PMID: 31016287

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Diseases : Osteoporosis

Therapeutic Actions : Laser Treatment: Low-Level

Additional Keywords : Ovariectomy-Induced Changes

[+]

Low‑molecular weight fucoidan inhibits the differentiation of osteoclasts and reduces osteoporosis in ovariectomized rats.Jan 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2017 Feb ;15(2):890-898. Epub 2016 Dec 20. PMID: 28000877

Article Published Date : Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2019 Feb 18. Epub 2019 Feb 18. PMID: 30816431

Article Published Date : Feb 17, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Magnolol

Diseases : Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Manganese supplementation improves mineral density in rats. Jul 01, 2008

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Pubmed Data : Biol Trace Elem Res. 2008 Jul;124(1):28-34. Epub 2008 Mar 11. PMID: 18330520

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Manganese

Diseases : Osteoporosis

[+]

Melatonin treatment is an efficient and practical strategy to improve in vitro expansion of BMMSCs for tissue engineering and cytotherapy.Dec 31, 2015

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Pubmed Data : Theranostics. 2016 ;6(11):1899-917. Epub 2016 Aug 8. PMID: 27570559

Article Published Date : Dec 31, 2015

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Pubmed Data : Exp Ther Med. 2016 May ;11(5):1881-1888. Epub 2016 Mar 10. PMID: 27168821

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Olive Oil

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Olive oil prevents bone loss in tumor patients and has excellent prospects for curing osteoporosis after menopause.Dec 31, 2013

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Pubmed Data : Clin Interv Aging. 2014 ;9:2087-95. Epub 2014 Dec 2. PMID: 25506212

Pubmed Data : J Nat Med. 2016 Apr ;70(2):225-33. Epub 2016 Jan 27. PMID: 26815435

[+]

Pueraria lobate inhibits RANKL-mediated osteoclastogenesis.Dec 31, 2016

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Pubmed Data : Am J Chin Med. 2017 ;45(8):1725-1744. Epub 2017 Nov 9. PMID: 29121799

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Kudzu

Diseases : Osteoporosis, Periodontitis, Rheumatoid Arthritis

Pharmacological Actions : Osteoprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Pueraria mirifica alleviates cortical bone loss in naturally menopausal monkeys.Oct 31, 2016

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Pubmed Data : J Endocrinol. 2016 Nov ;231(2):121-133. Epub 2016 Sep 6. PMID: 27601445

Article Published Date : Oct 31, 2016

Study Type : Animal Study

Additional Links

Substances : Pueraria mirifica

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Plant Extracts

[+]

Pueraria mirifica prevents bone loss in ovariectomized rats.Dec 01, 2009

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Pubmed Data : Eur J Pediatr. 2009 Dec;168(12):1541-2. Epub 2009 Mar 11. PMID: 18313241

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Pueraria mirifica

Diseases : Osteoporosis

[+]

Puerarin alleviates streptozotocin-induced osteoporosisApr 30, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 May 1 ;115:108570. Epub 2019 May 1. PMID: 31054509

Article Published Date : Apr 30, 2019

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Diabetic Complications, Osteoporosis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Osteoprotective

[+]

Puerarin and zinc additively prevent mandibular bone loss through inhibiting osteoclastogenesis in ovariectomized rats.Jul 31, 2017

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Pubmed Data : Histol Histopathol. 2017 Aug ;32(8):851-860. Epub 2016 Dec 14. PMID: 27966208

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Pubmed Data : Endocrinology. 2007 Jun;148(6):2669-80. Epub 2007 Mar 1. PMID: 17332064

Pubmed Data : Phytomedicine. 2010 Feb;17(2):116-25. Epub 2009 Jul 3. PMID: 19577454

Pubmed Data : Helicobacter. 2009 Aug;14(4):280-5. PMID: 20132045

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : FOS (Fructooligosaccharides), Plum

Diseases : Osteopenia, Osteoporosis

[+]

The combination of soy and FOS reverse the loss of certain microarchitectural parameters of the bone in osteopenic rats. Jul 01, 2006

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Emodin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

These results suggest that O. humifusa supplementation has a positive effect on bone density.Dec 31, 2011

Pubmed Data : J Bone Miner Metab. 2010 Feb 10. Epub 2010 Feb 10. PMID: 20145960

Article Published Date : Feb 10, 2010

Study Type : Animal Study

Additional Links

Substances : Vitamin E, Vitamin E: Gamma-tocotrienol

Diseases : Osteopenia, Osteoporosis

[+]

Vitamins K2 plus vitamin D combination could be a novel therapeutic strategy in treating diabetes-associated osteoporosis.Nov 14, 2015

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Pubmed Data : Eur J Pharmacol. 2015 Nov 15 ;767:30-40. Epub 2015 Oct 8. PMID: 26452518

Article Published Date : Nov 14, 2015

Study Type : Animal Study

Additional Links

Substances : Vitamin D, Vitamin K2

Diseases : Diabetic Complications, Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Natural Substance Synergy

[+]

Whey protein fractions has therapeutic effect in ovariectomy-induced blone loss in rats.Aug 01, 2005

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Pubmed Data : Br J Nutr. 2005 Aug;94(2):244-52. PMID: 16115359

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : PLoS One. 2013 ;8(12):e80873. Epub 2013 Dec 4. PMID: 24324641

Article Published Date : Dec 31, 2012

Aqueous extracts of pomegranate seed may be an alternative therapy for use in the management of secondary osteoporosis.Jun 02, 2016

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Pubmed Data : Int J Mol Med. 2016 Jun 3. Epub 2016 Jun 3. PMID: 27278225

Article Published Date : Jun 02, 2016

Study Type : In Vitro Study

Additional Links

Substances : Pomegranate Seed

Diseases : Osteoporosis

[+]

Asiatic acid could be a potential candidate for a novel treatment against osteoporosis.Feb 28, 2014

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Pubmed Data : Cell Biochem Biophys. 2014 Mar ;68(2):437-42. PMID: 23934183

Article Published Date : Feb 28, 2014

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid

Diseases : Osteoporosis

Pharmacological Actions : Osteogenic

[+]

Avenanthramides prevent osteoblast and osteocyte apoptosis. Jul 10, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 Jul 11 ;8(7). Epub 2016 Jul 11. PMID: 27409635

Article Published Date : Jul 10, 2016

Study Type : In Vitro Study

Additional Links

Substances : Avenanthramides, Oats

Diseases : Osteoporosis

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation

[+]

Baicalein can regulate bone formation via the mTORC1 pathway.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2015 ;9:5169-83. Epub 2015 Sep 9. PMID: 26392752

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Baicalein

Diseases : Osteoporosis

Additional Keywords : Ovariectomy-Induced Changes

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Greater dietary vitamin C intake was associated with a lower risk of hip fracture and osteoporosisMar 31, 2018

High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women.Apr 01, 2009

Long-term use of warfarin was associated with osteoporotic fractures, at least in men with atrial fibrillation. Jan 23, 2006

Low serum level of magnesium seems to be a risk factor for osteoporosis among the postmenopausal women.May 31, 2014

Puerarin showed upregulating effects on bone mass in ovariectomy-induced postmenopausal osteoporosis.Jul 02, 2019

Soy isoflavones prevent bone resorption and loss.Jul 09, 2019

Tai chi is effective in improving balance of older adults and in the absence of other interventions, reduces falls in the nonfrail elderly.Jan 01, 2011

There was an association between the increase of at least one serving of fruits and vegetables per day and decreases in the risk of fractures.Dec 31, 2018

This present systematic review indicated that acupuncture could be an effective therapy for treating osteoporosis.Dec 31, 2017

Vitamin K1 and K2 exhibit anti-fracture activity.Dec 01, 2009

A black cohosh extract is equipotent to conjugated estrogens in reducing menopausal symptoms and bone markers, without adverse effects. Mar 14, 2003

A specific exercise program targeting osteoporosis improves the condition of postmenopausal women with low bone density. Mar 01, 2009

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Alendronate use is associated with low-energy femoral shaft fractures. May 01, 2008

Although hip bone mineral density is strongly related to hip fracture risk in elderly white women, other clinical risk factors also are independent predictors of long-term risk.Sep 01, 2004

Arimidex therapy contributes in the decline of bone mineral density in early breast cancer patients.Jan 01, 2010

Beer drinking contributes to higher bone density as a result of the phytoestrogen content (hops) of this alcoholic beverage. Oct 01, 2009

Bisphosphonate use in chronic kidney disease is associated wtih adynamic bone disease.Jan 01, 2010

Bisphosphonates used for osteoporosis in patients with cystic fibrosis increases bone mineral density without increasing bone quality/strength, while causing bone pain and flu-like symptoms. Jan 01, 2009

Bone mineral density is a significant prognostic factor for postmenopausal Caucasian women with breast cancer. Low bone mineral density is associated with a lower local and distant rate of recurrence.Feb 28, 2013

Calcium supplementation (without vitamin D) is associated with increased risk of bone fracture.Aug 01, 2008

Calcium supplementation may actually increase the risk of bone fracture.Dec 01, 2007

Carotenoids such as lycopene have a protective effect on bone health.Jun 01, 2009

Correcting Dysbiosis may help to correct malabsorption and resulting bone disease.May 01, 2001

DHEA supplementation improved lower extremity strength and function in older, frail women involved in a gentle exercise program of chair aerobics or yoga.Oct 25, 2008

Dietary magnesium may play a role in musculoskeletal health.Oct 29, 2017

Dietary vitamin K2 supplement improves bone status after lung and heart transplantation.Feb 27, 2010

Dried plum improves bone mineral density in postmenopausal women. May 31, 2011

Dried plum in its whole form is a promising and efficacious functional food therapy for preventing bone loss in postmenopausal women.May 13, 2017

Dried plums improve indices of bone formation in postmenopausal women.Mar 01, 2010

Drinking up to 3 cups of tea per day was associated with a 30% reduction in the risk of hip fractures in women.Oct 31, 1995

DXA-generated Z-scores and T-scores may differ substantially and significantly in young adults.Oct 01, 2007

Elderly women with high bone mineral density (BMD) have up to 2.7 times greater risk of breast cancer, especially advanced cancer, compared with women with low BMD.Jun 20, 2001

Electromagnetic waves at high frequencies may decrease mean bone density, however, the results from this study were not statistically significant.Sep 01, 2009

Gamma-linolenic acid (GLA) and Eicosapentaenoic acid (EPA) have beneficial effects on bone in elderly patients. Oct 01, 1998

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.Oct 01, 2002

Genistein has a positive effect on bone metabolism in osteopenic postmenopausal women, without increasing endometrial thickness. Jun 19, 2007

Genistein is safe and effective in improving bone density without adverse responses in breast density or endometrium thickness in osteopenic, postmenopausal women. Dec 01, 2008

Green and yellow vegetable consumption is effective for maintaining bone mass in young women. Jan 01, 2009

Group exercise has a positive effect on postmenopausal osteoporosis and osteopenia.Aug 01, 2009

High consumption of coffee seems to contribute to a reduction in BMD Dec 31, 2009

Higher bone density (upper 33%) is associated with a 2-fold increased risk of breast cancer.Mar 01, 2003

Higher bone mass is associated with greater risk for breast cancer.Mar 20, 2007

Higher bone mineral density is associated with higher incidence of estrogen receptor positive breast cancer.Jul 20, 2007

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women. Dec 19, 2009

Increase in lumbar spine and femoral neck bone mineral density is associated with a 2.1 fold and 1.5 fold respectively, higher risk of breast cancer.Jul 31, 2000

Intake of fermented soybean (natto) increases circulating vitamin K2 and osteocalcin (a marker for bone formation) in normal individuals. Jan 01, 2000

Isoflavones attenuate bone loss and have a potentially protective effect on the lumbar spine in womenFeb 01, 2004

Lactobacillus reuteri reduces bone loss in older women with low bone mineral density.Jun 20, 2018

Long term use of vitamin C supplements was associated with a higher BMD in the early postmenopausal years and among never users of oestrogen.Sep 30, 1997

Long-term proton pump inhibitor therapy is associated with an increased risk of hip fracture.Dec 27, 2006

Long-term proton pump inhibitors use is associated with risk of bone complications.Feb 28, 2018

Long-term use of bisphosphonates is assocated with low-energy femoral fractures. Jan 01, 2009

Low levels of serum ascorbic acid in elderly patients with hip fracture.Apr 30, 1998

Magnesium deficiency may contribute to osteoporosis promotion associated with gluten-sensitive enteropathy.Jan 01, 1996

Magnesium may have beneficial effects in reducing bone loss associated with high bone turnover, such as age-related osteoporosis. Dec 27, 2002

Mammographic breast density is inversely associated with bone mineral density in the perimenopausal women.Aug 01, 2007

Menaquinone-7 (vitamin K2) supplementation increases osteocalcin carboxylation associated with improved bone quality.Oct 01, 2009

MK-7 in addition to ordinary meals could improve osteocalcin γ-carboxylation status.Dec 31, 2014

Most of the increase in mortality following hip and pelvic fractures is due to underlying conditions and probably would not be affected by reductions in the incidence of these fractures.Jul 22, 1996

Multiple hyperbaric oxygen treatments has the possibility of contributing to recovery acceleration in patients with transient osteoporosis of the hip.Oct 31, 2016

Natto, a rich source of vitamin K2, promotes bone formation in premenopausal women. Apr 01, 2004

Neuromuscular and visual impairments (as well as femoral-neck BMD) are significant and independent predictors of the risk of hip fracture in elderly women. Jul 20, 1996

one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.Jun 02, 2015

Oophorectomy adversely affect healthy postmenopausal women by accelerating loss of bone mineral density (BMD) and the rate of increase in carotid artery intima-media thickness (CIMT).Mar 31, 2014

Orthosilicic acid has therapeutic value in the treatment of osteopenia and osteoporosis. Jun 11, 2008

Osteoporosis rates are higher in adult patients with celiac disease.Mar 01, 1999

Patients with Gaucher disease living in England have a high frequency of vitamin D deficiency Mar 01, 2009

Prolonged intake of fermented soybean (natto) diets containing vitamin K2 (menaquinone-7) prevents bone loss in ovariectomized rats.Jan 01, 2000

Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.Jul 01, 2010

Reduced bone density in patients on long-term warfarin.Jul 01, 2009

Rosiglitazone and pioglitazone increase fracture risk in women and men with type 2 diabetes.Aug 01, 2010

Osteoporosis

View the Evidence:
397 Abstracts with Osteoporosis Research