Polycystic Ovary Syndrome

Name	AC	CK
Vitamin D	13	182
Inositol	5	41
Berberine	9	40
Coenzyme Q10	4	40
Folic Acid	4	40
NAC (N-acetyl-L-cysteine)	3	40
Cinnamon	6	35
Myo-inositol	4	31
D-Chiro-Inositol	3	30
Pomegranate	3	30
Flaxseed	4	25
Resveratrol	5	23
Licorice	3	22
Omega-3 Fatty Acids	3	22
Alpha-Lipoic Acid	2	20
Buckwheat	2	20
Magnesium	2	20
Vitamin E	2	20
Zinc	2	20
Chamomile	2	12
Curcumin	2	12
Onion	2	12
Spearmint	2	12
Fenugreek	2	11
Almond	1	10
Arginine	1	10
B-complex	1	10
Calcium	1	10
Chinense Herbal Formula: Jinqi Jiangtang	1	10
Chinese Herbal Formula: Tiangui Fang	1	10
Folate	1	10
Magnesium Sulfate	1	10
Probiotics	1	10
Selenium	1	10
Testosterone	1	10
Vinegar	1	10
Walnut	1	10
Ginseng (Korean)	3	6
Thymoquinone	3	6
Marjoram	1	5
Rutin	2	4
Vitamin C	2	4
Paeoniflorin	2	3
Quercetin	2	3
African Basil	1	2
Astaxanthin	1	2
Catechin	1	2
Crocetin	1	2
Genistein	1	2
Grape Seed Extract	1	2
Indole-3-Carbinol	1	2
Lactobacillus probiotics	1	2
Lutein	1	2
Moringa oleifera	1	2
Naringenin	1	2
Nettle	1	2
Nigella sativa (aka Black Seed)	1	2
Oolong tea	1	2
Peony	1	2
Royal Jelly	1	2
Safflower	1	2
Sage	1	2
Seaweed: Brown	1	2
Tanshinone IIA	1	2
Thujae occidentalis	1	2
Tribulus	1	2
Vitamin E: alpha tocopherol	1	2
Aloe Vera	1	1
Ginger	1	1
Green Tea	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Puerarin	1	1
Silymarin	1	1

Name	AC	CK
Bisphenol A	10	78
Metformin	2	20
Organochlorine pesticides	2	20
Pesticides	2	20
Insulin	1	10
Octylphenol	1	10
Phthalates	1	10
Polychlorinated biphenyls (PCBs)	1	10
Hydrocarbons	1	2
Jet fuel	1	2
Letrozole (trade name Femera)	1	2
Dexamethasone	1	1

Name	AC	CK
Acupuncture	7	52
Electroacupuncture	3	22
Exercise	2	20
Yoga	2	20
Dietary Modification: Low Carbohydrate/Ketogenic	1	10
Dietary Modification: Low Starch/Low Dairy	1	10
Integrative Medicine	1	10
Moxibustion	1	10
Laser Treatment: Low-Level	1	2
Fasting/Caloric Restriction	1	1

[+]

Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.Dec 31, 2017

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Pubmed Data : J Clin Endocrinol Metab. 2011 Mar ;96(3):623-31. Epub 2010 Dec 22. PMID: 21177795

Article Published Date : Mar 01, 2011

Study Type : Human Study

Additional Links

Diseases : Adrenal Hyperandrogenism, Polycystic Ovary Syndrome

Additional Keywords : Diseases that are Linked

[+]

A single bout of electroacupuncture remodels epigenetic and transcriptional changes in adipose tissue in polycystic ovary syndrome.Jan 29, 2018

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Pubmed Data : Sci Rep. 2018 Jan 30 ;8(1):1878. Epub 2018 Jan 30. PMID: 29382850

[+]

Beneficial effects of ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese.Feb 28, 2021

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Pubmed Data : J Obstet Gynaecol Res. 2021 Mar ;47(3):1145-1152. Epub 2021 Jan 18. PMID: 33462940

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Pubmed Data : Gynecol Endocrinol. 2017 Sep 26:1-6. Epub 2017 Sep 26. PMID: 28949260

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Pubmed Data : Gynecol Endocrinol. 2019 Jun 20:1-4. Epub 2019 Jun 20. PMID: 31219355

Article Published Date : Jun 19, 2019

Study Type : Human Study

Additional Links

Diseases : Bisphenol Toxicity, Polycystic Ovary Syndrome

Additional Keywords : Increased Risk

Problem Substances : Bisphenol A , Phthalates

[+]

Exercise improves psychological well-being in women with polycystic ovary syndrome.Dec 31, 2019

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Pubmed Data : Adv Exp Med Biol. 2020 ;1228:123-136. PMID: 32342454

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Diseases : Polycystic Ovary Syndrome

Therapeutic Actions : Exercise

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Pubmed Data : Gynecol Endocrinol. 2010 Dec;26(12):861-8. Epub 2010 Jul 20. PMID: 20642382

Article Published Date : Dec 01, 2010

Pubmed Data : Arch Iran Med. 2017 Oct ;20(10):640-645. PMID: 29137465

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2020 Nov 19 ;32(5):899-910. Epub 2020 Nov 19. PMID: 34592079

Article Published Date : Nov 18, 2020

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Infertility: Female, Polycystic Ovary Syndrome

Pharmacological Actions : Fertility Agents: Female

[+]

NAC can be used as a substitute for insulin-sensitizing agent in treatment of polycystic ovarian syndrome.Jan 31, 2019

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Pubmed Data : J Obstet Gynaecol India. 2019 Feb ;69(1):77-81. Epub 2018 May 28. PMID: 30814814

Article Published Date : Jan 31, 2019

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Insulin Sensitizers

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Metformin

[+]

NAC improves oocyte and embryo quality and could be administered as an alternative to metformin.Mar 31, 2016

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Pubmed Data : Reprod Fertil Dev. 2016 Apr ;28(6):723-31. PMID: 25482371

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Pubmed Data : J Res Med Sci. 2018 ;23:33. Epub 2018 Apr 26. PMID: 29887901

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Chamomile

Diseases : Polycystic Ovary Syndrome

[+]

Organochlorine pesticides levels may play a role in the pathogenesis of polycystic ovary syndrome by affecting hormones levels.Feb 28, 2017

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Pubmed Data : Chemosphere. 2017 Mar ;171:595-600. Epub 2016 Dec 26. PMID: 28043072

Article Published Date : Feb 28, 2017

Study Type : Human Study

Additional Links

Diseases : Pesticide Toxicity , Polycystic Ovary Syndrome

Additional Keywords : Risk Factors

Problem Substances : Organochlorine pesticides, Pesticides

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Resveratrol may improve some outcomes of PCOS patients.Jul 20, 2019

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Pubmed Data : J Assist Reprod Genet. 2019 Jul 21. Epub 2019 Jul 21. PMID: 31327131

Article Published Date : Jul 20, 2019

Study Type : Human Study

Additional Links

Substances : Resveratrol

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Hypoxia-inducible factor-1 (HIF-1) inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Resveratrol significantly reduced ovarian and adrenal androgens.Oct 17, 2016

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Pubmed Data : J Clin Endocrinol Metab. 2016 Oct 18:jc20161858. Epub 2016 Aug 18. PMID: 27754722

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Pubmed Data : J Hum Reprod Sci. 2017 Jan-Mar;10(1):31-36. PMID: 28479753

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Pubmed Data : Front Cell Neurosci. 2020 ;14:87. Epub 2020 Apr 9. PMID: 32327976

Cinnamon supplementation improves insulin resistance and may be a potential therapeutic agent for the treatment of PCOS.Oct 18, 2018

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Pubmed Data : Mol Med. 2020 Jul 22 ;26(1):73. Epub 2020 Jul 22. PMID: 32698821

Article Published Date : Jul 21, 2020

Study Type : Animal Study

Additional Links

Diseases : Polycystic Ovary Syndrome

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Autophagy Up-regulation

[+]

Grape seed extract could reduce the effects of dyslipidemia and inflammation in polycystic ovary syndrome.Sep 30, 2017

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Pubmed Data : Int J Fertil Steril. 2017 Oct ;11(3):176-183. Epub 2017 Aug 27. PMID: 28868839

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic, Interleukin-6 Downregulation

[+]

Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.Jul 21, 2019

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Pubmed Data : Nat Med. 2019 Jul 22. Epub 2019 Jul 22. PMID: 31332392

Article Published Date : Jul 21, 2019

Study Type : Animal Study

Additional Links

Diseases : Dysbiosis, Polycystic Ovary Syndrome

[+]

Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model.May 31, 2018

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Pubmed Data : Iran J Basic Med Sci. 2018 Jun ;21(6):645-650. PMID: 29942457

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Flaxseed

Diseases : Polycystic Ovary Syndrome, Testosterone: Too High

[+]

Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations.Mar 31, 2013

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Pubmed Data : Obstet Gynecol Sci. 2021 03 19. Epub 2021 Mar 19. PMID: 33743577

Article Published Date : Jan 18, 2021

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean)

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome.Feb 25, 2021

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Pubmed Data : Aging (Albany NY). 2021 Feb 26 ;13(5):7084-7095. Epub 2021 Feb 26. PMID: 33638949

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2020 Mar 11. Epub 2020 Mar 11. PMID: 32160160

Article Published Date : Mar 10, 2020

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Antioxidants

[+]

Resveratrol suppressed damage to the ovaries in PCOS rats by restoring glycolytic activity.Oct 18, 2021

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Pubmed Data : BMC Complement Med Ther. 2021 Feb 8 ;21(1):55. Epub 2021 Feb 8. PMID: 33557822

Article Published Date : Feb 07, 2021

Study Type : Animal Study

Additional Links

Substances : Lutein, Nettle

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Antioxidants

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The present study provides in vivo evidence that crocetin improved the polycystic ovarian syndrome in mice.Oct 31, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1363-1369. Epub 2018 Aug 31. PMID: 30257351

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Crocetin

Diseases : Polycystic Ovary Syndrome

[+]

The regulatory effect of genistein on granulosa cell in ovary of rat with polycystic ovarian syndrome.Aug 29, 2018

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Pubmed Data : Biomed Pharmacother. 2021 Mar 16 ;138:111468. Epub 2021 Mar 16. PMID: 33740526

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Pubmed Data : Reprod Biomed Online. 2016 Dec ;33(6):770-780. Epub 2016 Sep 16. PMID: 27717596

Article Published Date : Nov 30, 2016

Study Type : Review

Additional Links

Substances : Inositol

Diseases : Insulin Resistance, Obesity, Polycystic Ovary Syndrome

Pharmacological Actions : Insulin Sensitizers

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Insulin resistance directly exaggerates the androgenic potential within theca cells, suggesting the possible involvement of this ovarian metabolic phenotype in polycystic ovary syndrome hyperandrogenism.May 01, 2009

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Pubmed Data : Fertil Steril. 2009 May;91(5 Suppl):1990-7. Epub 2008 Jul 30. PMID: 18672234

Article Published Date : May 01, 2009

Study Type : In Vitro Study

Additional Links

Diseases : Insulin Resistance, Polycystic Ovary Syndrome

Additional Keywords : Diseases that are Linked

[+]

Myo-inositol is effective in normalizing ovarian function, improving oocyte and embryo quality in PCOS.Jan 18, 2021

Protective effects of berberine in a model of polycystic ovary syndrome.Mar 10, 2021

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Pubmed Data : J Obstet Gynaecol Res. 2021 Mar 11. Epub 2021 Mar 11. PMID: 33709493

Article Published Date : Mar 10, 2021

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Apoptotic, Insulin Sensitizers

[+]

Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic reviewJan 30, 2020

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Pubmed Data : Reprod Biol Endocrinol. 2021 Sep 23 ;19(1):147. Epub 2021 Sep 23. PMID: 34551795

Article Published Date : Sep 22, 2021

Study Type : Review

Additional Links

Substances : Green Tea

Diseases : Insulin Resistance, Polycystic Ovary Syndrome

Pharmacological Actions : Hypoglycemic Agents

[+]

This summarizes the role of dietary AGEs as mediators of metabolic and reproductive alterations in PCOS.Dec 03, 2015

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Pubmed Data : Nutrients. 2015 Dec 4 ;7(12):10129-44. Epub 2015 Dec 4. PMID: 26690206

Article Published Date : Dec 03, 2015

Study Type : Review

Additional Links

Diseases : Advanced Glycation End products (AGE), Polycystic Ovary Syndrome

Additional Keywords : Risk Factors

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View the Evidence: 176 Abstracts with Polycystic Ovary Syndrome Research

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Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.Dec 31, 2017

BPA might be involved in the insulin-resistance and hyperandrogenism of polycystic ovary syndrome.Nov 29, 2017

N-acetyl-cysteine may be considered as an alternative supplement to metformin in PCOS patients.Nov 20, 2019

Serum 25-hydroxyvitamin D, follicle stimulating hormone and sex hormone-binding globulin were significantly lower in PCOS patients than controls.Aug 09, 2017

Serum level of vitamin D was associated with the risk of polycystic ovary syndrome.Sep 13, 2015

Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome.Dec 31, 2020

Vitamin D supplementation had beneficial on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome.Feb 22, 2018

Vitamin D supplementation improves markers of polycystic ovarian syndrome.Apr 01, 2020

Vitamin D supplementation is sufficient for decreasing serum triglyceride.Dec 08, 2016

"Hyperandrogenism in women with polycystic ovary syndrome persists after menopause."Mar 01, 2011

A single bout of electroacupuncture remodels epigenetic and transcriptional changes in adipose tissue in polycystic ovary syndrome.Jan 29, 2018

Abdominal acupuncture treatment can improve the endocrine and metabolic function of patients with obesity-type polycystic ovarian syndrome. Aug 01, 2010

Acupuncture at Zhibian through Shuidao could significantly improve the basic temperature of patients with polycystic ovary syndrome, and regulate hormone level of reproductive endocrine.Apr 30, 2015

Acupuncture can effectively reduce FINS, HOMA-IR and WC levels in PCOS patients with abdominal obesity.Apr 24, 2018

Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin. Jun 01, 2005

Adrenal androgen excess in the polycystic ovary syndrome patients is related to an exaggerated secretory response of the adrenal cortex for DHEA and androstenedione (A4).Jul 01, 1998

An 8-week low-starch/low-dairy diet resulted in weight loss, improved insulin sensitivity and reduced testosterone in women with PCOS.Mar 31, 2015

Beneficial effects of ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese.Feb 28, 2021

Berberine can represent a safe novel dietary supplement, helpful in treatment strategy for PCOS.Oct 18, 2021

Bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls.Mar 31, 2015

Bodily retention of environmental organic pollutants-including PCBs, pesticides and PAHs-was associated with PCOS.Jul 31, 2015

BPA may play a major role in the pathogenesis of polycystic ovarian syndrome.Nov 30, 2017

Cinnamon reduces insulin resistance parameters in polycystic ovary syndrome.Apr 01, 2001

Cinnamon supplementation improved antioxidant status and serum lipid profile in women with PCOS.Dec 31, 2017

Co-administration of vitamin D and probiotic for 12 weeks to women with polycystic ovary syndrome had beneficial effects.Jan 20, 2019

Coenzyme Q10 and vitamin E had beneficial effects on cardiometabolic outcomes among women with polycystic ovary syndrome.Jan 31, 2019

Consuming daily synbiotic pomegranate juice improved metabolic, oxidative, inflammatory, and blood pressure outcomes in females with PCOS.Nov 10, 2019

Controlled-release alpha lipoic acid has a therapeutic effect in lean, nondiabetic patients with polycystic ovary syndrome.Mar 01, 2010

CoQ10 and vitamin E supplementation had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels.Sep 06, 2018

CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α.Sep 25, 2017

CoQ10 supplementation had beneficial effects in subjects with PCOS, involving glucose metabolism, serum total and LDL-cholesterol levels.Dec 01, 2016

Curcumin seems to be an efficient reducer of oxidative stress related complications in patients with PCOS.Jan 07, 2020

D-chiro-inositol has a therapeutic effect in lean women with the polycystic ovary syndrome.Nov 01, 2002

Electroacupuncture improves oocytes' growth in patients with polycystic ovary syndrome.Nov 30, 2019

Endocrine disruptors such as BPA could modify neuroendocrine, reproductive, and metabolic regulation favouring PCOS development in adolescents.Jun 19, 2019

Exercise improves psychological well-being in women with polycystic ovary syndrome.Dec 31, 2019

Flaxseed oil omega-3 supplementation for 12 weeks in women with PCOS had beneficial effects.Mar 31, 2018

Folate improves the effect of metformin treatment on vascular endothelial function in women with polycystic ovary sydrome. Feb 01, 2010

Folate supplementation for 8 weeks among women with PCOS had beneficial effects on metabolic profiles.Jun 30, 2014

Furocyst was efficacious in ameliorating the symptoms of polycystic ovary syndrome.Dec 31, 2014

Girls with PCOS and IR more hirsute, more AN, lower SHBG and higher fasting insulin levelsMay 31, 2010

in the form of a new beverage can improve insulin resistance, insulin, testosterone level, BMI, weight and waist circumference in PCOS. Dec 31, 2018

Increasing protein intake and restricting simple sugar intake may be therapeutic in polycystic ovary syndrome (PCOS)Mar 01, 2007

Inositol improves ovarian function in women with oligomenorrhea and polycystic ovaries.Nov 01, 2003

L-arginine appears to counteract the hypertensive properties of estradiol in patients with PCOS.Dec 01, 2010

Licorice reduces serum testosterone in healthy women. Oct 01, 2004

Licorice reduces the side effects of spironolactone in the treatment of polycystic ovary syndrome. Mar 01, 2007

Low intakes of dietary fiber and magnesium are associated with insulin resistance and hyperandrogenism in polycystic ovary syndrome.Mar 31, 2019

Lower serum magnesium was associated with aggravated insulin resistance and higher testosterone levels among women with PCOS.Dec 31, 2020

Magnesium and zinc co-supplementation for 12 weeks among women with PCOS had beneficial effects on inflammation and oxidative stress. Nov 09, 2017

Magnesium-zinc-calcium-vitamin D supplementation in patients with PCOS had beneficial effects on insulin metabolism and markers of cardio-metabolic risk.Sep 30, 2017

Myo-inositol decreases circulating insulin and serum testosterone as well as improvement in metabolic factors in women with polycystic ovary syndrome. Mar 01, 2009

Myo-inositol plus folic acid has a beneficial effect in improving ovarian function in women with oligomenorrhea and polycystic ovaries. Sep 01, 2007

Myo-inositol was useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle.Dec 31, 2016

N-acetyl-cysteine as adjuvant therapy in female infertility.Nov 18, 2020

NAC can be used as a substitute for insulin-sensitizing agent in treatment of polycystic ovarian syndrome.Jan 31, 2019

NAC improves oocyte and embryo quality and could be administered as an alternative to metformin.Mar 31, 2016

Octylphenol may play a role in insulin resistance in PCOS patients.Oct 01, 2011

Omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-γ and LDLR.Feb 23, 2017

Oral administration of chamomile capsule caused a significant decrease in total testosterone in patients with polycystic ovary syndrome.Dec 31, 2017

Organochlorine pesticides levels may play a role in the pathogenesis of polycystic ovary syndrome by affecting hormones levels.Feb 28, 2017

PCOS women are considered as a high-risk population for prediabetes.Sep 19, 2016

Progesterone resistance may play a role in polycystic ovary syndromeJun 01, 2011

Raw red onion consumption appears to be effective as a cholesterol-lowering food agent in women with polycystic ovary syndrome.Mar 31, 2014

Regular mindful yoga practice can be a useful complementary therapeutic option for women with polycystic ovary syndrome.Apr 13, 2020

Resveratrol may improve some outcomes of PCOS patients.Jul 20, 2019

Resveratrol significantly reduced ovarian and adrenal androgens.Oct 17, 2016

Selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.Aug 11, 2015

Serum vitamin D levels are correlated with metabolic risk factors in women with PCOS.Jan 01, 2020

Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. Jul 07, 2009

Taking myo-inositol by women with PCOS had beneficial effects on glycemic control, triglycerides and VLDL-cholesterol levels, and gene expression of PPAR-γ.Jan 03, 2019

The beneficial effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome.Jan 23, 2020

Polycystic Ovary Syndrome

View the Evidence:
176 Abstracts with Polycystic Ovary Syndrome Research