Vitamin C Deficiency

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4 Substances Researched for Vitamin C Deficiency
NameACCKFocus
Vitamin C1771Locked
Fruit: All110Locked
Vegetables: All 110Locked
Vitamin D11Locked
2 Problem Substances Researched for Vitamin C Deficiency
NameACCKFocus
Omeprazole (trade name Prisolec)110Locked
Proton-Pump Inhibitors110Locked

View the Evidence:
45 Abstracts with Vitamin C Deficiency Research

[+]

Animal-based nitrite may be an independent dietary risk factor for development of T2D in subjects with lower vitamin C intakes.Nov 30, 2016

Pubmed Data : Nitric Oxide. 2016 Dec 1. Epub 2016 Dec 1. PMID: 27916563
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Diabetes Mellitus: Type 2, Vitamin C Deficiency
Additional Keywords : Risk Factors, Risk Reduction
[+]

Data suggest that measurable health advantages are associated with vitamin C supplementation in men with adequate to low vitamin C status.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2014 Jul ;6(7):2572-83. Epub 2014 Jul 9. PMID: 25010554
Article Published Date : Jun 30, 2014
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Cold: Common, Upper Respiratory Infections, Vitamin C Deficiency
Pharmacological Actions : Antioxidants, Immune Enhancing Properties, Immunomodulatory
Additional Keywords : Physical Activity, Vitamin C Supplementation
[+]

Elevated serum lipid peroxidation and reduced vitamin c and trace element concentrations are correlated with epilepsy.Apr 30, 2018

Pubmed Data : Clin EEG Neurosci. 2018 May 1:1550059418772755. Epub 2018 May 1. PMID: 29788779
Article Published Date : Apr 30, 2018
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Epilepsy, Lipid Peroxidation, Vitamin C Deficiency
[+]

Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations.Mar 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Clin Nutr. 2013 Apr ;97(4):800-7. Epub 2013 Feb 27. PMID: 23446899
Article Published Date : Mar 31, 2013
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Vitamin C Deficiency
[+]

Low vitamin C values are linked with decreased physical performance and increased oxidative stressJan 31, 2016

Pubmed Data : Eur J Nutr. 2016 Feb ;55(1):45-53. Epub 2014 Dec 20. PMID: 25526969
Article Published Date : Jan 31, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Athletic Performance, Oxidative Stress, Vitamin C Deficiency
Pharmacological Actions : Antioxidants
[+]

Lower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Oct 23, 2015

Pubmed Data : Diabet Med. 2015 Oct 24. Epub 2015 Oct 24. PMID: 26498636
Article Published Date : Oct 23, 2015
Study Type : Human Study
Additional Links
Substances : Fruit: All, Vegetables: All , Vitamin C
Diseases : Diabetes Mellitus: Type 2: Prevention, Insulin Resistance, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

Proton pump inhibitors reduce the bioavailability of dietary vitamin C.Sep 15, 2005

Pubmed Data : Aliment Pharmacol Ther. 2005 Sep 15;22(6):539-45. PMID: 16167970
Article Published Date : Sep 15, 2005
Study Type : Human Study
Additional Links
Diseases : Vitamin C Deficiency
Additional Keywords : Drug: Omeprazole
Problem Substances : Omeprazole (trade name Prisolec), Proton-Pump Inhibitors
[+]

The results of this study shows associations between vitamin C and spinal pain.Jul 17, 2016

Pubmed Data : Pain. 2016 Jul 18. Epub 2016 Jul 18. PMID: 27434504
Article Published Date : Jul 17, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Back Pain, Neck Pain, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

The urinary concentrations of ascorbic acid were significantly lower in patients with lichen planus which was associated with infections. Apr 18, 2017

Pubmed Data : J Immunoassay Immunochem. 2017 Apr 19. Epub 2017 Apr 19. PMID: 28422565
Article Published Date : Apr 18, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Oral Lichen Planus, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

This evidence suggests that sub-optimal micronutrient intake may have a negative effect on cognition across the lifespan.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Behav Neurosci. 2019 ;13:115. Epub 2019 May 28. PMID: 31191268
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Substances : Vitamin C, Vitamin D
Diseases : Cognitive Decline/Dysfunction, Vitamin C Deficiency, Vitamin D Deficiency
Pharmacological Actions : Neuroprotective Agents
[+]

Total vitamin C and dietary vitamin C intake are inversely associated with hyperuricemia in the general US adult population.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asia Pac J Clin Nutr. 2018 ;27(6):1271-1276. PMID: 30485926
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Hyperuricemia, Vitamin C Deficiency
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Vitamin C deficiency moderated the relationship between inflammation and cardiac event risks in patients with heart failure.Dec 14, 2016

Pubmed Data : J Cardiovasc Nurs. 2016 Dec 15. Epub 2016 Dec 15. PMID: 27984333
Article Published Date : Dec 14, 2016
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Heart Failure, Inflammation, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

Vitamin C status correlates with markers of metabolic and cognitive health in 50-year-olds.Aug 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Aug 3 ;9(8). Epub 2017 Aug 3. PMID: 28771190
Article Published Date : Aug 02, 2017
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Vitamin C Deficiency
[+]

Vitamin D deficiency has a significant impact in heart failure patients.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dis Markers. 2019 ;2019:4145821. Epub 2019 Oct 13. PMID: 31737126
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Heart Failure, Vitamin C Deficiency
Pharmacological Actions : Cardioprotective
Additional Keywords : Risk Factors
[+]

Vitamin D deficiency may be related to high YKL-40 levels in terms of causing chronic inflammation.Feb 25, 2019

Pubmed Data : Int J Vitam Nutr Res. 2019 Feb 26:1-5. Epub 2019 Feb 26. PMID: 30806610
Article Published Date : Feb 25, 2019
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Inflammation, Vitamin C Deficiency
[+]

Lung anti-oxidant depletion: a predictive indicator of cellular stress induced by ambient fine particles.Jan 20, 2020

Pubmed Data : Environ Sci Technol. 2020 Jan 21. Epub 2020 Jan 21. PMID: 31961142
Article Published Date : Jan 20, 2020
Study Type : Human In Vitro
Additional Links
Diseases : Air Pollution Linked Toxicity, Glutathione Deficiency , Oxidative Stress, Vitamin C Deficiency
Additional Keywords : Risk Reduction
[+]

A case report suggests that mild vitamin C deficiency associated with metabolic syndrome and severe periodontal infection may be associated with the pathogenesis of severe gingival overgrowth.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Case Rep. 2014 Dec ;2(6):286-95. Epub 2014 Sep 4. PMID: 25548632
Article Published Date : Nov 30, 2014
Study Type : Human: Case Report
Additional Links
Substances : Vitamin C
Diseases : Gingivitis, Metabolic Diseases, Periodontal Diseases, Vitamin C Deficiency
Additional Keywords : Significant Treatment Outcome
[+]

Severe gingivitis associated with ascorbic acid-deficiency in a pediatric patient.May 14, 2019

Pubmed Data : J Dent Child (Chic). 2019 May 15 ;86(2):125-128. PMID: 31395119
Article Published Date : May 14, 2019
Study Type : Human: Case Report
Additional Links
Substances : Vitamin C
Diseases : Gingivitis, Periodontal Diseases, Vitamin C Deficiency
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This case describes a rare presentation of scurvy and highlights a previously under reported connection between scurvy and vasomotor instability.Dec 31, 2013

Pubmed Data : BMJ Case Rep. 2014 ;2014. Epub 2014 May 23. PMID: 24859547
Article Published Date : Dec 31, 2013
Study Type : Human: Case Report
Additional Links
Substances : Vitamin C
Diseases : Scurvy, Vitamin C Deficiency
Additional Keywords : Significant Treatment Outcome
[+]

Ascorbic acid deficiency induced inflammation related gene expression in the livers of deficient animals. Jan 31, 2015

Pubmed Data : Nutrition. 2015 Feb ;31(2):373-9. Epub 2014 Aug 1. PMID: 25592017
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Vitamin C Deficiency
Additional Keywords : Gene Expression
Adverse Pharmacological Actions : Inflammatory
[+]

Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain.Nov 29, 2019

Pubmed Data : Neurosci Lett. 2019 Nov 30:134656. Epub 2019 Nov 30. PMID: 31794791
Article Published Date : Nov 29, 2019
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Cardiovascular Diseases, Psychiatric Disorders, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

Lipoprotein(a) and vitamin C impair development of breast cancer tumors.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2016 Sep ;49(3):895-902. Epub 2016 Aug 1. PMID: 27573077
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Breast Cancer, Vitamin C Deficiency
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Risk Reduction
[+]

Maternal vitamin C regulates reprogramming of DNA methylation and germline development.Aug 31, 2019

Pubmed Data : Nature. 2019 Sep ;573(7773):271-275. Epub 2019 Sep 4. PMID: 31485074
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Vitamin C Deficiency
Additional Keywords : DNA Methylation, Transgenerational Epigenetic Modification
[+]

Mice with decreased ascorbic acid had increased oxidative stress in brain, increased mortality and faster seizure onset.Jan 31, 2015

Pubmed Data : Epilepsy Res. 2015 Feb ;110:20-5. Epub 2014 Nov 26. PMID: 25616451
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Epilepsy, Seizures, Seizures: Drug-Induced, Vitamin C Deficiency
Additional Keywords : Risk Factors, Risk Reduction
[+]

Severe liver damage induced by inflammation could be prevented by sufficient supplementation with vitamin C.Dec 09, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2013 Dec 10 ;19(17):2040-53. Epub 2013 Apr 18. PMID: 23472641
Article Published Date : Dec 09, 2013
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Hepatitis, Inflammation, Liver Damage, Vitamin C Deficiency
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

These findings suggest that vitamin C deficiency could induce spatial memory deficits.Jun 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2018 Jun 29 ;7(7). Epub 2018 Jun 29. PMID: 29966224
Article Published Date : Jun 28, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Memory Disorders, Vitamin C Deficiency
[+]

This animal study found that vitamin C depletion increased the growth and metastasis of melanoma cells. Nov 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Oncol. 2011 Dec ;33(4):226-30. PMID: 22217712
Article Published Date : Nov 30, 2011
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Melanoma: Metastasis, Skin Cancer, Vitamin C Deficiency
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Additional Keywords : Risk Factors
[+]

This study demonstrates the impact of suboptimal levels of ascorbate on longevity and the metabolic profile of a mouse model.Feb 19, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging (Albany NY). 2016 Feb 20. Epub 2016 Feb 20. PMID: 26922388
Article Published Date : Feb 19, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Inflammation, Metabolic Diseases, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory.Jan 07, 2019

Pubmed Data : Arch Biochem Biophys. 2019 Jan 8 ;663:120-128. Epub 2019 Jan 8. PMID: 30629958
Article Published Date : Jan 07, 2019
Study Type : Animal Study
Additional Links
Diseases : Inflammation, Vitamin C Deficiency, Vitamin E Deficiency
Additional Keywords : Risk Factors
[+]

Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance.Mar 19, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Mar 20 ;9(1):4702. Epub 2019 Mar 20. PMID: 30894591
Article Published Date : Mar 19, 2019
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Muscle Atrophy , Vitamin C Deficiency
[+]

Vitamin C is an important nutrient for adequate immune function and the limitation of pathogenesis following influenza virus infection.Sep 30, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr. 2006 Oct ;136(10):2611-6. PMID: 16988135
Article Published Date : Sep 30, 2006
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Influenza A, Vitamin C Deficiency
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Risk Factors
[+]

Vitamin C is essential for preventing and improving insulin resistance.Apr 02, 2018

Pubmed Data : Eur J Pharmacol. 2018 Apr 3. Epub 2018 Apr 3. PMID: 29625084
Article Published Date : Apr 02, 2018
Study Type : Animal Study
Additional Links
Diseases : Insulin Disorders, Vitamin C Deficiency
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Anti-Inflammatory Agents, Insulin Disorders, Vitamin C Deficiency
[+]

Vitamin C is essential for the renal function maintenance in diabetes.Dec 31, 2016

Pubmed Data : Biochim Biophys Acta. 2017 09 ;1861(9):2186-2195. Epub 2017 Jun 23. PMID: 28652077
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Vitamin C Deficiency
Pharmacological Actions : Renoprotective
[+]

"The genetics of vitamin C loss in vertebrates."Aug 01, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Genomics. 2011 Aug ;12(5):371-8. PMID: 22294879
Article Published Date : Aug 01, 2011
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Scurvy, Vitamin C Deficiency
[+]

Ascorbate could act as an adjuvant therapy for severe sepsis and septic shock.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Crit Care. 2015 ;19(1):418. Epub 2015 Nov 27. PMID: 26612352
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Sepsis, Septic Shock, Vitamin C Deficiency
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Ascorbic acid serum levels are reduced in patients with hematological malignancies.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Results Immunol. 2016 ;6:8-10. Epub 2016 Jan 12. PMID: 27014565
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Liver Diseases, Vitamin C Deficiency
[+]

Deficiency of vitamin D and vitamin C could alter the pathogenesis of bronchial asthma.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bratisl Lek Listy. 2016 ;117(6):305-7. PMID: 27546360
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Vitamin C, Vitamin D
Diseases : Bronchial Asthma, Vitamin C Deficiency, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

Limited vitamin C availability resulted in a functional type II cell but a cell more sensitive to oxidant-induced injury.Sep 30, 1997

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 1997 Oct 1 ;273(4):L782-L788. PMID: 29585842
Article Published Date : Sep 30, 1997
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Oxidative Stress, Vitamin C Deficiency
Pharmacological Actions : Antioxidants
[+]

Low tumor tissue ascorbate levels were associated with high HIF-1 activation and tumor growth.Jul 14, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Res. 2010 Jul 15 ;70(14):5749-58. Epub 2010 Aug 22. PMID: 20570889
Article Published Date : Jul 14, 2010
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Endometrial Cancer, Vitamin C Deficiency
Pharmacological Actions : Hypoxia-inducible factor-1 (HIF-1) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Proton pump inhibitors low gastric vitamin C levels resulting in a rise of nitrate, reduce the absorption of vitamin B-12 and reduce the absorption of non-heme iron.Mar 01, 2009

Pubmed Data : Am J Gastroenterol. 2009 Mar;104 Suppl 2:S5-9. PMID: 19262546
Article Published Date : Mar 01, 2009
Study Type : Commentary
Additional Links
Diseases : Anemia: Iron Deficiency, Helicobacter Pylori Infection, Vitamin B 12 Deficiency, Vitamin C Deficiency
Additional Keywords : Drug: Omeprazole
[+]

Reprogramming the epigenome with vitamin C.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2019 ;7:128. Epub 2019 Jul 16. PMID: 31380368
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Cancers: All, Vitamin C Deficiency
Additional Keywords : Epigenetic Modification In Cancer
[+]

Tumor necrosis factor alpha (TNF-α) reduces intestinal vitamin C uptake.Apr 05, 2018

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2018 Apr 6. Epub 2018 Apr 6. PMID: 29631379
Article Published Date : Apr 05, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Inflammation, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

Vitamin C deficiency and the injection of foreign proteins can cause a high blood histamine level, leading to capillary fragility and venular bleeding.Jan 01, 2004

Pubmed Data : Med Hypotheses. 2004 ;62(4):533-6. PMID: 15050101
Article Published Date : Jan 01, 2004
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Shaken Baby Syndrome, Vaccine-induced Toxicity , Vitamin C Deficiency
Anti Therapeutic Actions : Vaccination: All
[+]

Vitamin C deficiency is an under-diagnosed contributor to degenerative disc disease in the elderly.Mar 31, 2010

Pubmed Data : Med Hypotheses. 2010 Apr ;74(4):695-7. Epub 2009 Nov 22. PMID: 19932568
Article Published Date : Mar 31, 2010
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Degenerative Disk Disease, Vitamin C Deficiency
Additional Keywords : Risk Factors
[+]

Vitamins and bone health: beyond calcium and vitamin D.Sep 30, 2011

Pubmed Data : Nutr Rev. 2011 Oct ;69(10):584-98. PMID: 21967159
Article Published Date : Sep 30, 2011
Study Type : Review
Additional Links
Substances : B-complex, Vitamin A, Vitamin C, Vitamin E, Vitamin K
Diseases : Osteoporosis, Vitamin C Deficiency, Vitamin D Deficiency
Pharmacological Actions : Osteoprotective

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