Natural Health Research Discovery

Each Topic is an Index of Curated Biomedical Research Abstracts

Pharmacological Actions (501)

ALLA B C D E F G H I J L M N O P Q R S T U V W X Z Β
Pharmacological Action NameCumulative Knowledgesort iconAbstractsPDF
Antioxidants215288856Downloadable Document
Anti-Inflammatory Agents208598334Downloadable Document
Neuroprotective Agents104044396Downloadable Document
Apoptotic69865304Downloadable Document
Antiproliferative68015032Downloadable Document
Tumor Necrosis Factor (TNF) Alpha Inhibitor67362815Downloadable Document
Cardioprotective53771675Downloadable Document
Chemopreventive53741717Downloadable Document
Hypoglycemic Agents53661338Downloadable Document
Hypolipidemic53581221Downloadable Document
Hepatoprotective50982264Downloadable Document
Interleukin-6 Downregulation50291994Downloadable Document
Antidepressive Agents4882874Downloadable Document
Antihypertensive Agents4527683Downloadable Document
Immunomodulatory40481475Downloadable Document
NF-kappaB Inhibitor35362098Downloadable Document
Analgesics3498646Downloadable Document
Gastrointestinal Agents3145843
Anticholesteremic Agents3078530Downloadable Document
Interleukin-1 beta downregulation30411567Downloadable Document
Anti-Anxiety Agents2913487
Anti-Apoptotic29051672Downloadable Document
Anti-Bacterial Agents28941251Downloadable Document
Renoprotective24041075Downloadable Document
Chemotherapeutic23281086
Chemoprotective Agents2322906
Malondialdehyde Down-regulation2065678Downloadable Document
Anti-metastatic19721481Downloadable Document
Antiviral Agents19571034Downloadable Document
Anticarcinogenic Agents1890889Downloadable Document
Antineoplastic Agents18471170Downloadable Document
Cell cycle arrest16781348Downloadable Document
Radioprotective1668521Downloadable Document
Cyclooxygenase 2 Inhibitors1589926Downloadable Document
Nrf2 activation1584916
Superoxide Dismutase Up-regulation1403551Downloadable Document
Antimicrobial1209582Downloadable Document
Insulin Sensitizers1185244Downloadable Document
Chemosensitizer1124854Downloadable Document
MicroRNA modulator1023618
Osteoprotective971351
Gastroprotective955388Downloadable Document
Anti-Fibrotic924463Downloadable Document
Matrix metalloproteinase-9 (MMP-9) inhibitor786505Downloadable Document
Prophylactic Agents780182
Matrix metalloproteinase-2 (MMP-2) inhibitor727442Downloadable Document
Enzyme Inhibitors692347Downloadable Document
Anticonvulsants678189Downloadable Document
Cytoprotective659326
Antinoceceptive647197Downloadable Document
Detoxifier644202Downloadable Document
Immunostimulatory633192Downloadable Document
Vasodilator Agents626169Downloadable Document
Heme oxygenase-1 up-regulation624373
Tumor Suppressor Protein p53 Upregulation585431Downloadable Document
Interleukin-8 downregulation581231Downloadable Document
Bcl-2 protein down-regulation553407Downloadable Document
Anti-Ulcer Agents523184Downloadable Document
Autophagy Up-regulation518349Downloadable Document
Nitric Oxide Inhibitor498258Downloadable Document
Antifungal Agents494306Downloadable Document
Angiogenesis Inhibitors488296
Genoprotective477177Downloadable Document
Anxiolytic47566Downloadable Document
Hypotensive46763Downloadable Document
Brain-derived neurotrophic factor modulator458166
Photoprotective446198
Anti-Allergic Agents442150Downloadable Document
Antidiarrheals43987
Vascular Endothelial Growth Factor Inhibitors435247
Regenerative408172
Pancreato Protective Agents358194
Interleukin-4 downregulation355128Downloadable Document
Anti-atherogenic348120
Anti-Angiogenic347234Downloadable Document
Interleukin-10 downregulation335128Downloadable Document
Glutathione Upregulation29996Downloadable Document
Radiosensitizer291182Downloadable Document
Anti-Asthmatic Agents28671
Alpha-glucosidase inhibitor274201Downloadable Document
Dermatologic Agents27232Downloadable Document
Catalase Up-Regulation264112
Nitric Oxide Enhancer26176Downloadable Document
Telomere Protective23129
Adiponectin upregulation21739
Neurogenesis215109
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor214142
Antiparasitic Agents208121Downloadable Document
Wnt/β-catenin signaling pathway modulation208149
Vasoprotective20752
Uricosuric Agents20544
Transforming growth factor beta (TGF-β) inhibitor203106
Postaglandin PGE2 downregulation202110
Cardiovascular Agents20132Downloadable Document
Platelet Aggregation Inhibitors20045Downloadable Document
Anti-Glycation Agents197100
Prostaglandin PGE2 downregulation19388Downloadable Document
Interleukin-17 downregulation19385
Neuritogenic18589Downloadable Document
Vascular Endothelial Growth Factor A Inhibitor17997Downloadable Document
Secretagogue17838Downloadable Document
Immunomodulatory: Th17 downregulation17781
Autophagy Inhibitors175115
Alpha-amylase inhibitor175110
Acetylcholinesterase Inhibitor17095Downloadable Document
Matrix metalloproteinase-3 (MMP-3) inhibitor16968
Antimutagenic Agents16499Downloadable Document
Anti-Adipogenic16485Downloadable Document
P21 Activation160119
Anti-Tumor15476Downloadable Document
Matrix Metalloproteinase-13 (MMP-13) Inhibitor14566
Antispasmodic14037Downloadable Document
Interleukin-12 downregulation13953
Caspase-3 Activation13790Downloadable Document
Anti-Platelet13747Downloadable Document
Telomerase Upregulation13734Downloadable Document
Anti-HIV Agents13384Downloadable Document
Interleukin-18 down-regulation13261
Glucagon Like peptide 1 (GLP-1) Up-regulation12935Downloadable Document
Heat Shock Protein Inducer12648Downloadable Document
Vascular Cell Adhesion Molecule-1 Inhibitor12334Downloadable Document
Interleukin-2 Downregulation12351
Insulin-releasing12249Downloadable Document
Interleukin-5 downregulation12049
Leishmanicidal11879Downloadable Document
Interleukin-4 upregulation11342
Cyclin D1 Down-Regulation10679
Cardiotonic Agents10610
Interleukin-10 upregulation10524
Interleukin-1 alpha downregulation10242Downloadable Document
Matrix metalloproteinase-1 (MMP-1) inhibitor9959
Angiotensin-Converting Enzyme Inhibitors9954Downloadable Document
Histone deacetylase inhibitor9869Downloadable Document
Calcium Channel Blockers9829Downloadable Document
Telomerase Inhibitor9562Downloadable Document
Phase II Detoxification Enzyme Inducer9552Downloadable Document
DNA Repair Up-regulation9327
Antimalarials9053Downloadable Document
Fertility Agents: Female9018
interleukin-13 down-regulation9047
Angiogenesis Inducing Agents8845
Epidermal growth factor receptor (EGFR) inhibitor8760Downloadable Document
Insulin-Like Growth Factor Inhibition/Downregulation8618Downloadable Document
Neuroplasticity enhancement8323
Immunosuppressive Agents8043Downloadable Document
Anti-Cachexic Agents7926
Bronchodilator Agents7815Downloadable Document
Anti-thrombotic7632Downloadable Document
Cytotoxic7660
Cyclooxygenase Inhibitors7442Downloadable Document
Galactogogue738
Neurorestorative7121Downloadable Document
Caspase-9 Activation7046
NF-E2-Related Factor-2 (Nrf2) Modulator6939
Xanthine oxidase inhibitor6934Downloadable Document
Anti-Proliferative6755Downloadable Document
Aphrodisiac6722Downloadable Document
Anti-Infective Agents6640
Cyclooxygenase 1 Inhibitor6548Downloadable Document
Appetite Suppresant6414
Ergogenic638
Anti-pyretic6224
Malonaldehyde (MDA) Down-Regulation6215
Vascular Endothelial Growth Factor Regulator6229Downloadable Document
Antiprotozoal Agents6132
Antiemetics605
Fertility Agents: Male6014
Interferon-gamma (IFN-gamma) inducer6018
Proteasome Inhibitors5940Downloadable Document
Interferon Gamma Reducer5824
Estrogen Receptor Modulators5834Downloadable Document
Heme oxygenase-1 inducer5739
Thermogenic579
Serotonergic5612
Diuretics5514Downloadable Document
Antitussive Agents5414
Cholagogues and Choleretics5412Downloadable Document
STAT3 Inhibitor5331
Osteogenic5212
Interleukin-2 upregulation5113
Lipoxygenase Inhibitors5027Downloadable Document
Lipolytic4918Downloadable Document
Anti-Retroviral Agents4918
Quorum Sensing Inhibition4949
Interleukin-12 upregulation4813
Reverse Transcriptase Inhibitors4729Downloadable Document
Enzyme Inhibitors: Pancreatic Lipase4619
Aromatase Inhibitors4533Downloadable Document
Histamine Antagonists4517Downloadable Document
Histamine Antagonists4517Downloadable Document
Tumor Necrosis Factor (TNF) Alpha Enhancer4413
GABA Modulators4417
Appetite Depressants429
Heat Shock Protein Down-Regulation4222
Laxative426
Chelating Agents4121
Interferon Inducers4110
Bax/Bcl2 ratio: Increase4032
Iron Chelating Agents4015
Appetite Stimulants398
SIRT1 Activator3923
Insulin Down-Regulation387
Leukotriene Antagonists389
Neuromodulatory376
Ghrelin Down-Regulation366
Glucagon Like Peptide 1 (GLP-1) Down-Regulation356
Antimycobacterial3519Downloadable Document
Analgesics: Non-Narcotic3510
5-Lipoxygenase Inhibitor3521
Bcl-xL down-regulation3526
Uterotonic3411Downloadable Document
Spermatogenic3412
Cholecystokinin (CCK) Up-regulation345
Interleukin-6 upregulation3211
Caspase-8 activation3222
Dopaminergic3210Downloadable Document
Photosensitizing Agents3215
Cholinesterase Inhibitors3223
Aldose reductase inhibitor329
Transforming growth factor beta (TGF-β) upregulation3214
Antiurolithiatic319
HIV Protease Inhibitors3119Downloadable Document
Carcinogens312
Interleukin-8 upregulation303
Bax/Bcl2 Ratio: Decrease2918
Enzyme Activators2918
Protein Kinase Inhibitors2919Downloadable Document
Adiponectin Down-Regulation278
Prostaglandin Antagonists2713Downloadable Document
Glucose Uptake Optimization269
Detoxifier: Radionuclide Removal255
Androgen Antagonists255
Interleukin-22 Downregulation2410
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor234
Natriuretic Agents234
Leptin Down-Regulation238
Viral Hemagglutinin Inhibitor2216Downloadable Document
Chymotrypsin Inhibitor212
Gluconeogenesis Inhibitor2115Downloadable Document
Fibroblast growth factor 21 upregulation2111
Cholecystokinin Releaser202
Adenosine deaminase inhibitor207
Neurominidase Inhibitor2019Downloadable Document
Hypnotics and Sedatives206
Hematopoietic209
Topoisomerase II Inhibitor1917
Anticoagulants1815
Peptide YY (PYY) Up-Regulation164
P38 Mitogen-Activated Protein Kinase Modulator1611
Antioxidant Effects154
Hepatocyte growth factor (HGF) inhibitor154
Antitubercular Agents155
Survivin Down-Regulation1513
Protease Inhibitors156
Antipsychotic Agents152
Glutathione S-transferase Inhibitor144
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor144
Teratogens143
Cell Differentiation Inducer1411
Paraptosis1414
Anti-collagenase132
Topoisomerase I inhibitor1311
Matrix Metalloproteinase-12 (MMP-12) Inhibitor137
Leukotriene B4 downregulation134
Carminative122
Dopamine Agents122
Immunomodulatory: T-Cell down-regulation122
Anti-edemic122
Vasopressin Inhibitor122
VEGFR3 inhibition123
Insulin Receptor Modulator122
Mucolytic122
Endocannabinoid down-regulation122
Mitogen-activated protein kinase kinase 4 (MEK4)112
Insulinotrophic117
Interleukin-1 receptor antagonist112
Mitogen-activated protein kinase inhibitors112
Peptide YY (PYY) Down-regulation101
Isoprostane Down-Regulation101
cAMP up-regulation101
Interleukin-13 Up-Regulation101
Phosphorylase Kinase Inhibitors101
STAT3 Activation108
Fatty Acid Oxidation101
Glutathione peroxidase 1 (GPx1) inhibitors101
PER2 Protein Expression Up-regulation101
Interleukin-23 Downregulation101
Immune Enhancing Properties101
Insulin Antagonists101
Intracellular adhesion molecule down-regulation101
Respiratory System Agents101
Interleukin-3 upregulation101
Diacylglyceride acyltransferase 1 (DGAT1) Inhibition101
Drug sparing101
Immunostimulatory: IgA Production Up-Regulation101
Matrix Metalloproteinases Inhibitors106
Immunomodulatory: CD23+ Mature Macrophage Down-Regulation101
Gastric Inhibitory Polypeptide Up-Regulation101
Hormones101
Antilipemic Agents101
Alkylating Agents101
Neurotransmitter Uptake Inhibitors101
Immunomodulatory: Immunoglobulin G up-regulation101
Interleukin 1 receptor antagonist (IL-1Ra) up-regulation101
NOX2 inhibitor101
Oxytocin inducer101
Insulin-mimetic96
Cannabinoid Receptor Antagonist/Inverse Agonist97
Analgesics: Opioid96
Redox Modulator95
Insecticidal84
Benzodiazepine receptor agonist86
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK72
Antigiardial agents74
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation72
Vascular smooth muscle cell (VSMC) inhibitor75
Excitatory Amino Acid Agonists74
Trypsin Inhibitors64
AMP-activated protein kinase modulation64
Monoaminergic63
Interleukin-18 upregulation64
5-Lipoxygenase Inhibitor65
Trypanocidal Agents65
Interleukin-21 downregulation63
Spermicidal Activity51
Extracellular Signal-Regulated Kinases Modulator54
HIV Fusion Inhibitors54
HMG-CoA reductase inhibitor54
Antacids51
Insulin-Like Growth Factor Enhancer/Upregulation53
Antithrombotic42
Adrenergic alpha-Agonists43
Matrix Metalloproteinase-7 (MMP-7) Inhibitor41
Monoamine Oxidase Inhibitors42
Vascular Endothelial Growth Factor A Enhancer42
Ghrelin Up-regulation42
Contraceptive Agents: Male42
Angiotensin II Type 1 Receptor Blockers42
Anticholinergic42
Erythropoietic43
Intracellular adhesion molecule-1 (ICAM-1)43
Phase I Detoxification Enzyme Inducer42
SGLT1 inducer42
Mitochondrial Superoxide Dismutase Upregulation43
Schistosomicides42
Anti-Inflammatory Agents: Non-Steroidal42
Immunomodulatory: Regulatory T Cell Up-Regulation42
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation42
Thrombolytic42
Survival protein down-regulation32
Adrenergic beta-Agonists32
Matrix metalloproteinase-8 (MMP-8) inhibitor32
NF-kappa-B-inducing kinase (NIK) modulator32
Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation32
Cholinergic Agents32
Forkhead Transcription Factor Family O (FOXO) Modulator32
Interleukin-15 downregulation32
Antimitotic Agents33
Cholinergic Antagonists32
Steroidogenesis32
TRAIL sensitizer32
Estradiol 3-glucuronide enhancer33
Platelet aggregation inhibitor: collagen-induced aggregation32
Quinone Reductase-Inducer32
Cyclin-Dependent Kinase Inhibitor33
Glucose transporter-2 (GLUT2) expression down-regulation32
Atrial Natriuretic Factor Modulation32
Histamine down-regulation32
Leukotriene C4 Downregulation22
Muscarinic Antagonists22
Antidiuretic Agents21
P-glycoprotein Inhibitors22
Hydroperoxidase Inhibitor21
Endothelin-1 Inhibitor21
ER beta receptor up-regulation21
Food Preservatives22
GSH-Px Up-Regulation21
Thromboxane B2 Inhibitor22
1-Glutamine Uptake Inhibitor22
JAM3 gene down-regulation21
Remyelination21
Opioid Endogenous Up-regulation21
Insecticides21
Akt-dependent HO-1 expression up-regulation21
Progestagenic21
Angiogenesis Modulating Agents21
Bronchoconstrictor Agents21
Myorelaxant21
Serotonin Agonists21
Environmental Pollutants21
Peroxisome Proliferators21
Antiparkinson Agents21
Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation21
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor22
Progesterone receptor (PR) up-regulation21
RANTES (CCL5) Inhibitor22
Myosin heavy chain alpha (MHCalpha) reducer21
Serum ceruloplasmin oxidase reducer21
Histamine Agents21
Tumor Necrosis Factor (TNF) Alpha Upregulation21
Fertility Agents21
Lymphagogue21
Arginine Vasopressin (AVP) up-regulation.21
Reactive Oxygen Species (ROS) attenuation22
C-Jun N-Terminal Kinases (JNK) Modulator22
Stomachic21
Ovogenic21
Histamine Agonists21
Vascular Endothelial Growth Factor C Inhibitor21
Glycine Agents21
Phase I Detoxification Enzyme Inhibitor21
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor21
Sigma-1 Receptor Agonist22
Nootropic Agents21
Immunomodulatory: CD8+ Up-regulation21
Enzyme Inhibitors: Maltase Inhibition21
Incretin Modulator21
Antinitrosation21
Adjuvants: Immunologic21
Redox Balancer21
Calcium Desensitizer21
Noradrenergic21
Cicatrizing21
Uncoupling Agents21
Human androgen receptor (AR) antagonist22
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK)22
Abortifacient Agents21
Adrenergic Agents21
Anesthetics21
Muscarinic Agonists21
Neutrophil Activation: Down-Regulation21
Central Nervous System Agents21
Coccidiostats21
Cyclin-Dependent Kinase Inhibitor: P1622
Death receptor up-regulation21
Follicle-stimulating hormone receptor (FSHR) up-regulation21
Gene Protective21
Phospholipase D Inhibitors11
Mast Cell Activation Inhibitor11
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation11
Serine Proteinase Inhibitors11
Neuroimmunomodulation11
Antibiotics: Antifungal11
Cyclin-dependent kinase inhibitor: P16INK411
Histamine up-regulation11
Hypoxia-inducible factor-1 (HIF-1) inhibitor11
Zinc-dependent metalloproteinase inhibitor11
Leukotriene D4 antagonist11
PPAR-Gamma Up-Regulation11
Alpha-hemolysin inhibitor11
Molecular Probes11
Breast cancer resistance protein (BCRP) down-regulation11
Muscle Relaxants: Central11
Cancerous inhibitor of protein phosphatase 2A inhibitor11
P16 Activation11
Hydroxyheptadecatrienoate (HHT) Inhibitor11
Dopamine Agonists11
IGF-1R expression down-regulation11
Enkephalinase inhibitor11
β-secretase Inhibitor11
Interleukin-1 beta upregulation11
Contraceptive Agents11
17beta-hydroxysteroid dehydrogenase inhibitor11
Lactate Dehydrogenase A Inhibitor11
Matrix Metalloproteinase-8 Inhibitor11
RANK Downregulation11
Antifibrinolytic Agents11
Herbicides11
Eryptotic11
Fatty Acid Synthesis Inhibitors11
p300/NF-κB down-regulation11
5-HTergic11
Arginase 1 (Arg1) up-regulation11
Carbonyl Reductase 1Inhibitor11
Hematologic Agents11
Cryoprotective Agents11
5-Hydroxyeicosatetraenoic acid (5-HETE) Inhibitor11
PI3K/Akt/signaling suppression11
Akt-SREBP-1 activater11
Matrix metalloproteinase-14 (MMP-14) inhibitor11
Chondroprotective11
Dipeptidyl-Peptidase IV Inhibitors11
E-cadherin down-regulation11
Palmitoylation Inhibitors11
Ionophores11
PKM2 downregulation11
Matrix metalloproteinase-17 (MMP-17) inhibitor11
Psychedelic11
mTOR/S6K pathway Activator11
S-phase kinase associated protein 2 inhibition11
Neovasculogenesis11
Sulfonation11
Oxidants11
Cyclin-Dependent Kinase 4 Down-Regulation11
Tyrosinase Inhibition11
Disinfectants11
Hypomethylating11
Emmenagogue11
Vitamin D Receptor (VDR) Modulator11
Estrogen Antagonists11
IRAK-MAPK Modulator11
Astringents11
Oxytocics11
Transient Receptor Potential Melastatin 2 Inhibition11
Cytotoxins11
Glyoxalase 1 inhibitor11
Antilipolytic11
Phosphodiesterase Inhibitors11
Maspin (Protease Inhibitor) Up-Regulation11
Prostaglandin H Synthase-1 (PGHS-1) Inhibits11
Beta-Defensin-2 Up-Regulation11
Calcium/calmodulin dependent protein kinase II inhibitor11
Anti-cancer11
Superoxide Scavenger11
Hemolytic Agents11
Human Polymorphonuclear Leukocyte Degranulation Inhibitor11
Endocannabinoid Modulator11
Insect Repellents11
Glucose transporter-5 (GLUT5) expression down-regulation11

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