1-Glutamine Uptake Inhibitor | 2 | 2 | |
1-Leucine Uptake Inhibitor | 1 | 1 | |
12-lipoxygenase (12-LOX) | 2 | 2 | |
12-lipoxygenase (12-LOX) Inhibitor | 1 | 1 | |
15-Lipoxygenase (15-LOX) Inhibitor | 1 | 1 | |
17beta-hydroxysteroid dehydrogenase inhibitor | 1 | 1 | |
5-alpha reductase inhibitor | 34 | 14 |  |
5-HTergic | 1 | 1 | |
5-Hydroxyeicosatetraenoic acid (5-HETE) Inhibitor | 1 | 1 | |
5-Lipoxygenase Inhibitor | 6 | 5 | |
5-Lipoxygenase Inhibitor | 8 | 7 | |
Abortifacient Agents | 2 | 1 | |
Acetylcholinesterase Down-Regulation | 2 | 1 | |
Acetylcholinesterase Inhibitor | 37 | 19 |  |
Acid Blockers | 40 | 16 |  |
Adenosine deaminase inhibitor | 16 | 5 | |
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK | 7 | 2 | |
Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation | 2 | 1 | |
Adiponectin Down-Regulation | 2 | 1 | |
Adiponectin upregulation | 51 | 11 | |
Adjuvants: Immunologic | 2 | 1 | |
Adrenergic Agents | 2 | 1 | |
Adrenergic Agonists | 2 | 2 | |
Adrenergic alpha-Agonists | 4 | 3 | |
Adrenergic alpha-Antagonists | 11 | 2 | |
Adrenergic beta-Agonists | 3 | 2 | |
Air Pollutants: Radioactive | 1 | 1 | |
Akt-dependent HO-1 expression up-regulation | 2 | 1 | |
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor | 2 | 2 | |
Akt-SREBP-1 activater | 1 | 1 | |
Aldose reductase inhibitor | 15 | 4 | |
Alkylating Agents | 10 | 1 | |
Alpha-amylase inhibitor | 34 | 20 | |
Alpha-glucosidase inhibitor | 162 | 111 |  |
Alpha-hemolysin inhibitor | 1 | 1 | |
Aminopeptidase N (APN/CD13) inhibitor | 1 | 1 | |
AMP-activated protein kinase modulation | 2 | 2 | |
Anabolic Agents | 44 | 11 |  |
Analgesics | 2569 | 470 |  |
Analgesics: Non-Narcotic | 25 | 9 | |
Analgesics: Opioid | 7 | 4 | |
Androgen Antagonists | 25 | 5 | |
Androgens | 10 | 1 | |
Anesthetics | 2 | 1 | |
Angiogenesis Inducing Agents | 2 | 1 | |
Angiogenesis Inhibitors | 114 | 62 | |
Angiogenesis Modulating Agents | 2 | 1 | |
Angiotensin II Type 1 Receptor Blockers | 4 | 2 | |
Angiotensin-Converting Enzyme Inhibitors | 24 | 16 |  |
Antacids | 5 | 1 | |
Anti Inflammatory | 68 | 12 | |
Anti-Adipogenic | 110 | 52 |  |
Anti-Allergic Agents | 167 | 61 |  |
Anti-Androgen | 60 | 18 |  |
Anti-Angiogenic | 282 | 192 |  |
Anti-Anxiety Agents | 356 | 59 | |
Anti-Apoptotic | 1620 | 932 |  |
Anti-Arrhythmia Agents | 2 | 1 | |
Anti-Asthmatic Agents | 24 | 3 | |
Anti-atherogenic | 156 | 39 | |
Anti-bacterial | 1 | 1 | |
Anti-Bacterial Agents | 2088 | 821 |  |
Anti-Cachexic Agents | 2 | 1 | |
Anti-cancer | 1 | 1 | |
Anti-collagenase | 13 | 2 | |
Anti-edemic | 12 | 2 | |
Anti-elastase | 2 | 2 | |
Anti-Estrogenic | 3 | 1 | |
Anti-Fibrotic | 46 | 29 |  |
Anti-Glycation Agents | 46 | 19 | |
Anti-HIV Agents | 111 | 63 |  |
Anti-Infective Agents | 43 | 18 | |
Anti-Infective Agents: Urinary | 3 | 2 | |
Anti-Inflammatory Agents | 12461 | 4729 |  |
Anti-Inflammatory Agents: Non-Steroidal | 4 | 2 | |
Anti-leukemia Effects | 2 | 1 | |
Anti-metastatic | 1284 | 927 |  |
Anti-Platelet | 125 | 38 |  |
Anti-Proliferative | 59 | 52 |  |
Anti-Psychotic | 1 | 1 | |
Anti-pyretic | 28 | 9 | |
Anti-Retroviral Agents | 16 | 1 | |
Anti-thrombotic | 56 | 24 |  |
Anti-Tumor | 146 | 73 |  |
Anti-Ulcer Agents | 390 | 140 |  |
Antibacterial Effects | 1 | 1 | |
Antibiotics: Antifungal | 1 | 1 | |
Anticarcinogenic Agents | 1577 | 756 |  |
Anticholesteremic Agents | 2126 | 382 |  |
Anticholinergic | 4 | 2 | |
Anticoagulants | 3 | 2 | |
Anticonvulsants | 534 | 146 |  |
Antidepressive Agents | 2853 | 522 |  |
Antidepressive Agents: Second-Generation | 1 | 1 | |
Antidiarrheals | 110 | 20 | |
Antidiuretic Agents | 2 | 1 | |
Antiemetics | 40 | 4 | |
Antifibrinolytic Agents | 1 | 1 | |
Antifungal Agents | 403 | 237 |  |
Antigiardial agents | 4 | 2 | |
Antihypertensive Agents | 2852 | 424 |  |
Antilipemic Agents | 10 | 1 | |
Antilipolytic | 1 | 1 | |
Antimalarials | 41 | 24 |  |
Antimicrobial | 776 | 352 |  |
Antimitotic Agents | 2 | 2 | |
Antimutagenic Agents | 164 | 99 |  |
Antimycobacterial | 35 | 19 |  |
Antineoplastic Agents | 1594 | 982 |  |
Antinitrosation | 2 | 1 | |
Antinoceceptive | 492 | 153 |  |
Antioxidant | 9 | 4 | |
Antioxidant Effects | 15 | 4 | |
Antioxidants | 14410 | 5758 |  |
Antiparasitic Agents | 150 | 84 |  |
Antiparkinson Agents | 2 | 1 | |
Antiproliferative | 4773 | 3450 |  |
Antiprotozoal Agents | 47 | 19 | |
Antipruritics | 2 | 1 | |
Antipsychotic Agents | 15 | 2 | |
Antispasmodic | 132 | 32 |  |
Antithrombotic | 4 | 2 | |
Antitubercular Agents | 12 | 3 | |
Antitussive Agents | 12 | 2 | |
Antiurolithiatic | 20 | 2 | |
Antiviral Agents | 1307 | 596 |  |
Anxiolytic | 379 | 57 |  |
Apaf-1/caspase-dependent apoptotic pathway activator | 1 | 1 | |
Aphrodisiac | 63 | 20 |  |
Apoptotic | 5217 | 3846 |  |
Appetite Depressants | 8 | 4 | |
Appetite Stimulants | 10 | 1 | |
Appetite Suppresant | 26 | 6 | |
Arginase 1 (Arg1) up-regulation | 1 | 1 | |
Arginine Vasopressin (AVP) up-regulation. | 2 | 1 | |
Aromatase Inhibitors | 37 | 27 |  |
Arylesterase down-regulation | 2 | 1 | |
Astringents | 1 | 1 | |
Atrial Natriuretic Factor Modulation | 3 | 2 | |
Autophagy Inhibitors | 26 | 13 | |
Autophagy Up-regulation | 296 | 197 |  |
Bax/Bcl2 Ratio: Decrease | 15 | 9 | |
Bax/Bcl2 ratio: Increase | 25 | 19 | |
Bcl-2 protein down-regulation | 419 | 295 |  |
Bcl-xL down-regulation | 1 | 1 | |
Benzodiazepine receptor agonist | 8 | 6 | |
Beta-Defensin-2 Up-Regulation | 1 | 1 | |
Bone Density Conservation Agents | 6 | 3 | |
Brain-Associated Sulfotransferase Down-Regulation | 1 | 1 | |
Brain-derived neurotrophic factor modulator | 18 | 5 | |
BRCA-1 Downregulation | 2 | 2 | |
Breast cancer resistance protein (BCRP) down-regulation | 1 | 1 | |
Bronchoconstrictor Agents | 2 | 1 | |
Bronchodilator Agents | 56 | 12 |  |
C-Jun N-Terminal Kinases (JNK) Modulator | 2 | 2 | |
Calcium Channel Blockers | 87 | 23 |  |
Calcium Desensitizer | 2 | 1 | |
Calcium/calmodulin dependent protein kinase II inhibitor | 1 | 1 | |
cAMP up-regulation | 10 | 1 | |
Cancerous inhibitor of protein phosphatase 2A inhibitor | 1 | 1 | |
Cannabinoid Receptor Antagonist/Inverse Agonist | 1 | 1 | |
Carbonyl Reductase 1Inhibitor | 1 | 1 | |
Carcinogens | 31 | 2 | |
Cardioprotective | 3412 | 1032 |  |
Cardiotonic Agents | 46 | 7 | |
Cardiovascular Agents | 160 | 24 |  |
Carminative | 12 | 2 | |
Caspase-14 Upregulation | 1 | 1 | |
Caspase-2 Activation | 1 | 1 | |
Caspase-3 Activation | 137 | 90 |  |
Caspase-3 Inhibition | 4 | 2 | |
Caspase-7 Activation | 2 | 2 | |
Caspase-8 activation | 27 | 6 | |
Caspase-9 Activation | 30 | 19 | |
Catalase Up-Regulation | 118 | 42 | |
Cell cycle arrest | 1289 | 1006 |  |
Cell Differentiation Inducer | 6 | 5 | |
Central Nervous System Agents | 2 | 1 | |
Central Nervous System Depressants | 10 | 1 | |
Chelating Agents | 12 | 1 | |
Chemokine (C-C motif) Ligand 2 (CCL2) Down-Regulation | 3 | 2 | |
Chemopreventive | 4220 | 1326 |  |
Chemoprotective Agents | 356 | 146 | |
Chemosensitizer | 772 | 577 |  |
Chemosterilants | 1 | 1 | |
Chemotherapeutic | 397 | 152 | |
Chemotherapeuticm | 1 | 1 | |
Cholagogues and Choleretics | 54 | 12 |  |
Cholecystokinin (CCK) Up-regulation | 34 | 5 | |
Cholecystokinin Releaser | 20 | 2 | |
Cholinergic Agents | 3 | 2 | |
Cholinergic Antagonists | 3 | 2 | |
Cholinesterase Inhibitors | 10 | 8 | |
Chondroprotective | 1 | 1 | |
Chymotrypsin Inhibitor | 21 | 2 | |
Cicatrizing | 2 | 1 | |
Coccidiostats | 2 | 1 | |
Contraceptive Agents | 1 | 1 | |
Contraceptive Agents: Male | 4 | 2 | |
Cryoprotective Agents | 1 | 1 | |
Cyclin D1 Down-Regulation | 42 | 28 | |
Cyclin-Dependent Kinase 4 Down-Regulation | 1 | 1 | |
Cyclin-Dependent Kinase Inhibitor | 3 | 3 | |
Cyclin-Dependent Kinase Inhibitor: P16 | 2 | 2 | |
Cyclin-dependent kinase inhibitor: P16INK4 | 1 | 1 | |
Cyclooxygenase 1 Inhibitor | 34 | 27 |  |
Cyclooxygenase 2 Inhibitors | 1114 | 645 |  |
Cyclooxygenase Inhibitors | 71 | 39 |  |
CYP1A1 Transcription Inhibitor | 2 | 1 | |
CYP3A enzyme induction | 10 | 1 | |
Cytoprotective | 190 | 94 | |
Cytotoxic | 76 | 60 | |
Cytotoxins | 1 | 1 | |
Death receptor up-regulation | 2 | 1 | |
Dermatologic Agents | 240 | 28 |  |
Detoxifier | 512 | 171 |  |
Detoxifier: Radionuclide Removal | 23 | 4 | |
Diacylglyceride acyltransferase 1 (DGAT1) Inhibition | 10 | 1 | |
Dipeptidyl-Peptidase IV Inhibitors | 1 | 1 | |
Disinfectants | 1 | 1 | |
Diuretics | 53 | 11 |  |
DNA Repair Up-regulation | 67 | 16 | |
Dopamine Agents | 12 | 2 | |
Dopamine Agonists | 1 | 1 | |
Dopamine Antagonists | 1 | 1 | |
Dopamine Receptor D3 Antagonist | 1 | 1 | |
Dopaminergic | 32 | 10 |  |
Drug sparing | 10 | 1 | |
Drug synergy | 40 | 11 |  |
E-cadherin down-regulation | 1 | 1 | |
Emmenagogue | 1 | 1 | |
Endocannabinoid down-regulation | 12 | 2 | |
Endocannabinoid Modulator | 1 | 1 | |
Endothelin-1 Inhibitor | 2 | 1 | |
Enkephalinase inhibitor | 1 | 1 | |
Enoyl-acyl Carrier Protein (ACP) Reductase Inhibitors | 1 | 1 | |
Environmental Pollutants | 2 | 1 | |
Enzyme Activators | 4 | 2 | |
Enzyme Inhibitors | 602 | 312 |  |
Enzyme Inhibitors: Maltase Inhibition | 2 | 1 | |
Enzyme Inhibitors: Pancreatic Amylase | 1 | 1 | |
Enzyme Inhibitors: Pancreatic Lipase | 12 | 2 | |
EpCAM surface marker down-regulation | 1 | 1 | |
Epidermal growth factor receptor (EGFR) inhibitor | 65 | 41 |  |
ER alpha receptor up-regulation | 2 | 1 | |
ER beta receptor up-regulation | 2 | 1 | |
Ergogenic | 43 | 6 | |
Erk/MAP Inactivation | 1 | 1 | |
Eryptotic | 1 | 1 | |
Erythropoietic | 4 | 3 | |
Estradiol 3-glucuronide enhancer | 3 | 3 | |
Estradiol Antagonists | 2 | 1 | |
Estrogen Antagonists | 3 | 1 | |
Estrogen Receptor Agonist | 2 | 2 | |
Estrogen Receptor Modulators | 51 | 31 |  |
Excitatory Amino Acid Agonists | 7 | 4 | |
Expectorants | 1 | 1 | |
Extracellular Signal-Regulated Kinases Modulator | 5 | 4 | |
Fatty Acid Oxidation | 10 | 1 | |
Fatty Acid Synthesis Inhibitors | 1 | 1 | |
Fertility Agents | 2 | 1 | |
Fertility Agents: Female | 10 | 1 | |
Fertility Agents: Male | 60 | 14 | |
Fibrinolytic Agents | 28 | 6 | |
Fibroblast growth factor 21 upregulation | 2 | 1 | |
Follicle-stimulating hormone receptor (FSHR) up-regulation | 2 | 1 | |
Food Preservatives | 1 | 1 | |
Forkhead Transcription Factor Family O (FOXO) Modulator | 3 | 2 | |
GABA Modulators | 11 | 7 | |
Galactogogue | 73 | 8 | |
Gastric Inhibitory Polypeptide Up-Regulation | 10 | 1 | |
Gastrointestinal Agents | 268 | 41 | |
Gastroprotective | 534 | 228 |  |
Gene Protective | 2 | 1 | |
Genoprotective | 413 | 148 |  |
Ghrelin Down-Regulation | 36 | 6 | |
Ghrelin Up-regulation | 4 | 2 | |
Glucagon Like Peptide 1 (GLP-1) Down-Regulation | 35 | 6 | |
Glucagon Like peptide 1 (GLP-1) Up-regulation | 125 | 33 |  |
Gluconeogenesis Inhibitor | 19 | 14 |  |
Glucose transporter-1 (GLUT1) expression down-regulation | 2 | 2 | |
Glucose transporter-2 (GLUT2) expression down-regulation | 3 | 2 | |
Glucose transporter-2 (GLUT2) expression up-regulation | 10 | 1 | |
Glucose transporter-5 (GLUT5) expression down-regulation | 1 | 1 | |
Glucose Uptake Optimization | 16 | 1 | |
Glutathione peroxidase 1 (GPx1) inhibitors | 10 | 1 | |
Glutathione Peroxidase 1 (GPx1) Up-Regulation | 3 | 2 | |
Glutathione S-transferase Inhibitor | 4 | 3 | |
Glutathione Upregulation | 152 | 53 |  |
Glycine Agents | 2 | 1 | |
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor | 14 | 4 | |
Glyoxalase 1 inhibitor | 1 | 1 | |
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhibitor | 1 | 1 | |
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation | 4 | 2 | |
GSH-Px Up-Regulation | 2 | 1 | |
Heat Shock Protein Down-Regulation | 1 | 1 | |
Heat Shock Protein Inducer | 83 | 30 |  |
Hematologic Agents | 1 | 1 | |
Hematopoietic | 20 | 9 | |
Heme oxygenase-1 inducer | 8 | 5 | |
Heme oxygenase-1 up-regulation | 73 | 40 | |
Hemolytic Agents | 1 | 1 | |
Hepatocyte growth factor (HGF) inhibitor | 15 | 4 | |
Hepatoprotective | 3182 | 1418 |  |
HER-2 oncoprotein down-regulation | 2 | 1 | |
Herbicides | 1 | 1 | |
High-mobility group box-1 (HMGB1) inhibitor | 2 | 1 | |
Histamine Agents | 2 | 1 | |
Histamine Agonists | 2 | 1 | |
Histamine Antagonists | 45 | 17 |  |
Histamine Antagonists | 45 | 17 |  |
Histamine down-regulation | 3 | 2 | |
Histamine H2 Antagonists | 2 | 2 | |
Histamine up-regulation | 1 | 1 | |
Histone deacetylase inhibitor | 48 | 37 |  |
HIV Fusion Inhibitors | 5 | 4 | |
HIV Protease Inhibitors | 29 | 17 |  |
HIV-1 Integrase Inhibitor | 3 | 3 | |
HMG-CoA reductase inhibitor | 3 | 2 | |
Hormones | 10 | 1 | |
Human androgen receptor (AR) antagonist | 2 | 2 | |
Human Polymorphonuclear Leukocyte Degranulation Inhibitor | 1 | 1 | |
Hydroperoxidase Inhibitor | 2 | 1 | |
Hydroxyheptadecatrienoate (HHT) Inhibitor | 1 | 1 | |
Hypnotics and Sedatives | 20 | 6 | |
Hypoglycemic Agents | 3297 | 841 |  |
Hypolipidemic | 3189 | 707 |  |
Hypomethylating | 1 | 1 | |
Hypotensive | 435 | 59 |  |
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor | 22 | 15 | |
Hypoxia-inducible factor-1 (HIF-1) inhibitor | 1 | 1 | |
IGF-1R expression down-regulation | 1 | 1 | |
Immune Enhancing Properties | 10 | 1 | |
Immunomodulatory | 2249 | 733 |  |
Immunomodulatory: CD23+ Mature Macrophage Down-Regulation | 10 | 1 | |
Immunomodulatory: CD8+ Up-regulation | 2 | 1 | |
Immunomodulatory: Immunoglobulin G up-regulation | 10 | 1 | |
Immunomodulatory: Immunoglobulin M Up-Regulation | 10 | 1 | |
Immunomodulatory: Innate Immunity Up-Regulation | 12 | 2 | |
Immunomodulatory: Regulatory T Cell Up-Regulation | 4 | 2 | |
Immunomodulatory: T-Cell down-regulation | 12 | 2 | |
Immunomodulatory: Th17 downregulation | 30 | 17 | |
Immunostimulatory | 442 | 114 |  |
Immunostimulatory: IgA Production Up-Regulation | 10 | 1 | |
Immunosuppressive Agents | 37 | 24 |  |
Incretin Modulator | 2 | 1 | |
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK) | 2 | 2 | |
Insect Repellents | 1 | 1 | |
Insecticidal | 8 | 4 | |
Insecticides | 2 | 1 | |
Insulin Antagonists | 10 | 1 | |
Insulin Down-Regulation | 12 | 2 | |
Insulin Receptor Modulator | 12 | 2 | |
Insulin Sensitizers | 707 | 139 |  |
Insulin-Like Growth Factor Enhancer/Upregulation | 5 | 3 | |
Insulin-Like Growth Factor Inhibition/Downregulation | 76 | 17 |  |
Insulin-mimetic | 9 | 6 | |
Insulin-releasing | 62 | 28 |  |
Insulinotrophic | 11 | 7 | |
Intercellular adhesion molecule 3 down-regulation | 3 | 2 | |
Interferon Gamma Reducer | 58 | 24 | |
Interferon Inducers | 31 | 9 | |
Interferon-gamma (IFN-gamma) inducer | 24 | 8 | |
Interleukin 1 receptor antagonist (IL-1Ra) up-regulation | 10 | 1 | |
Interleukin-1 alpha downregulation | 42 | 17 |  |
Interleukin-1 alpha upregulation | 3 | 2 | |
Interleukin-1 beta downregulation | 1743 | 868 |  |
Interleukin-1 beta upregulation | 1 | 1 | |
Interleukin-1 receptor antagonist | 11 | 2 | |
Interleukin-10 downregulation | 284 | 103 |  |
Interleukin-10 upregulation | 105 | 24 | |
Interleukin-12 downregulation | 9 | 5 | |
Interleukin-12 upregulation | 17 | 5 | |
interleukin-13 down-regulation | 2 | 1 | |
Interleukin-13 Up-Regulation | 10 | 1 | |
Interleukin-15 downregulation | 3 | 2 | |
Interleukin-17 downregulation | 39 | 13 | |
Interleukin-17 upregulation | 4 | 2 | |
Interleukin-18 down-regulation | 20 | 7 | |
Interleukin-18 upregulation | 1 | 1 | |
Interleukin-2 Downregulation | 4 | 3 | |
Interleukin-2 upregulation | 43 | 8 | |
Interleukin-21 downregulation | 2 | 1 | |
Interleukin-22 Downregulation | 10 | 1 | |
Interleukin-23 Downregulation | 10 | 1 | |
Interleukin-3 upregulation | 10 | 1 | |
Interleukin-4 downregulation | 119 | 34 |  |
Interleukin-4 upregulation | 12 | 2 | |
Interleukin-5 downregulation | 25 | 4 | |
Interleukin-5 upregulation | 2 | 1 | |
Interleukin-6 Downregulation | 3054 | 1144 |  |
Interleukin-6 upregulation | 26 | 7 | |
Interleukin-8 downregulation | 406 | 147 |  |
Interleukin-8 upregulation | 20 | 2 | |
Intracellular adhesion molecule down-regulation | 10 | 1 | |
Intracellular adhesion molecule-1 (ICAM-1) | 4 | 3 | |
Ionophores | 1 | 1 | |
IRAK-MAPK Modulator | 1 | 1 | |
Iron Chelating Agents | 4 | 3 | |
Isoprostane Down-Regulation | 10 | 1 | |
JAM3 gene down-regulation | 2 | 1 | |
Lactate Dehydrogenase A Inhibitor | 1 | 1 | |
Laxative | 42 | 6 | |
Leishmanicidal | 38 | 24 |  |
Leptin Down-Regulation | 13 | 3 | |
Leukotriene Antagonists | 38 | 9 | |
Leukotriene B4 downregulation | 13 | 4 | |
Leukotriene C4 Downregulation | 2 | 2 | |
Leukotriene D4 antagonist | 1 | 1 | |
Lipolytic | 45 | 16 |  |
Lipotropic Agents | 2 | 1 | |
Lipoxygenase Inhibitors | 38 | 17 |  |
Lymphagogue | 2 | 1 | |
Malonaldehyde (MDA) Down-Regulation | 20 | 6 | |
Malondialdehyde Down-regulation | 1452 | 466 |  |
Maspin (Protease Inhibitor) Up-Regulation | 1 | 1 | |
Mast Cell Activation Inhibitor | 1 | 1 | |
Matrix metalloproteinase-1 (MMP-1) inhibitor | 32 | 16 | |
Matrix Metalloproteinase-12 (MMP-12) Inhibitor | 2 | 1 | |
Matrix Metalloproteinase-13 (MMP-13) Inhibitor | 23 | 11 | |
Matrix metalloproteinase-14 (MMP-14) inhibitor | 1 | 1 | |
Matrix metalloproteinase-16 (MMP-16) inhibitor | 1 | 1 | |
Matrix metalloproteinase-17 (MMP-17) inhibitor | 1 | 1 | |
Matrix metalloproteinase-2 (MMP-2) inhibitor | 551 | 315 |  |
Matrix metalloproteinase-3 (MMP-3) inhibitor | 61 | 18 | |
Matrix Metalloproteinase-7 (MMP-7) Inhibitor | 4 | 1 | |
Matrix metalloproteinase-8 (MMP-8) inhibitor | 3 | 2 | |
Matrix Metalloproteinase-8 Inhibitor | 1 | 1 | |
Matrix metalloproteinase-9 (MMP-9) inhibitor | 543 | 337 |  |
Matrix Metalloproteinases Inhibitors | 3 | 2 | |
Metal Chelation: Copper | 1 | 1 | |
Metallothionein Up-regulation | 12 | 2 | |
MicroRNA modulator | 264 | 145 | |
Mitochondrial Superoxide Dismutase Upregulation | 4 | 3 | |
Mitogen-activated protein kinase inhibitors | 11 | 2 | |
Mitogen-activated protein kinase kinase 4 (MEK4) | 11 | 2 | |
Molecular Probes | 1 | 1 | |
Monoamine Oxidase Inhibitors | 4 | 2 | |
Monoaminergic | 6 | 3 | |
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor | 1 | 1 | |
mTOR/S6K pathway Activator | 1 | 1 | |
Mucolytic | 12 | 2 | |
Multidrug Resistance Gene Modulators | 20 | 15 | |
Muscarinic Agonists | 2 | 1 | |
Muscarinic Antagonists | 2 | 2 | |
Muscle Relaxants: Central | 1 | 1 | |
Myorelaxant | 2 | 1 | |
Myosin heavy chain alpha (MHCalpha) reducer | 2 | 1 | |
NADPH Oxidase Inhibitors | 1 | 1 | |
Natriuretic Agents | 23 | 4 | |
Neocardiogenic | 8 | 7 | |
Neocardiogenic | 8 | 7 | |
Neovasculogenesis | 1 | 1 | |
Neuritogenic | 133 | 59 |  |
Neurogenesis | 59 | 30 | |
Neuroimmunomodulation | 1 | 1 | |
Neurominidase Inhibitor | 17 | 16 |  |
Neuromodulatory | 2 | 1 | |
Neuroplasticity enhancement | 44 | 12 | |
Neuroprotective Agents | 6374 | 2801 |  |
Neurorestorative | 71 | 21 |  |
Neurotransmitter Uptake Inhibitors | 10 | 1 | |
Neutrophil Activation: Down-Regulation | 2 | 1 | |
Neutrophil Rolling Inhibitor | 2 | 1 | |
NF-E2-Related Factor-2 (Nrf2) Modulator | 48 | 26 | |
NF-kappa-B-inducing kinase (NIK) modulator | 3 | 2 | |
NF-kappaB Inhibitor | 2446 | 1436 |  |
Nitric Oxide Enhancer | 190 | 47 |  |
Nitric Oxide Inhibitor | 390 | 196 |  |
Nonpeptidyl Inhibitors | 1 | 1 | |
Nootropic Agents | 2 | 1 | |
Noradrenergic | 2 | 1 | |
NOX2 inhibitor | 10 | 1 | |
Nrf2 activation | 177 | 86 | |
Oncogene Suppressor | 15 | 11 |  |
Opioid Endogenous Up-regulation | 2 | 1 | |
Osteogenic | 52 | 12 | |
Osteoprotective | 20 | 6 | |
Ovogenic | 2 | 1 | |
Oxidants | 1 | 1 | |
Oxytocics | 1 | 1 | |
Oxytocin inducer | 10 | 1 | |
P-glycoprotein Inhibitors | 2 | 2 | |
P16 Activation | 1 | 1 | |
P21 Activation | 72 | 47 | |
p300/NF-κB down-regulation | 1 | 1 | |
P38 Mitogen-Activated Protein Kinase Modulator | 6 | 5 | |
Palmitoylation Inhibitors | 1 | 1 | |
Pancreato Protective Agents | 40 | 23 | |
Paraoxonase down-regulation | 2 | 1 | |
Paraptosis | 1 | 1 | |
Peptide YY (PYY) Down-regulation | 10 | 1 | |
Peptide YY (PYY) Up-Regulation | 16 | 4 | |
PER2 Protein Expression Up-regulation | 10 | 1 | |
Peroxisome Proliferators | 2 | 1 | |
Phase I Detoxification Enzyme Inducer | 4 | 2 | |
Phase I Detoxification Enzyme Inhibitor | 2 | 1 | |
Phase II Detoxification Enzyme Inducer | 78 | 40 |  |
Phosphodiesterase Inhibitors | 1 | 1 | |
Phospholipase D Inhibitors | 1 | 1 | |
Phosphorylase Kinase Inhibitors | 10 | 1 | |
Phosphorylated Rb Down-Regulation | 1 | 1 | |
Photoprotective | 74 | 27 | |
Photosensitizing Agents | 1 | 1 | |
PI3K-AKT inhibitor | 1 | 1 | |
PI3K/Akt/signaling suppression | 1 | 1 | |
PKM2 downregulation | 1 | 1 | |
Platelet aggregation inhibitor: collagen-induced aggregation | 1 | 1 | |
Platelet Aggregation Inhibitors | 186 | 40 |  |
Postaglandin PGE2 downregulation | 23 | 11 | |
PPAR-Gamma Up-Regulation | 1 | 1 | |
PRL-3 Down-Regulation | 1 | 1 | |
Progestagenic | 2 | 1 | |
Progesterone receptor (PR) up-regulation | 2 | 1 | |
Prophylactic Agents | 129 | 31 | |
Prostaglandin Antagonists | 27 | 13 |  |
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation | 2 | 1 | |
Prostaglandin H Synthase-1 (PGHS-1) Inhibits | 1 | 1 | |
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation | 1 | 1 | |
Prostaglandin PGE2 downregulation | 187 | 83 |  |
Prostaglandin PGF2 downregulation | 2 | 2 | |
Protease Inhibitors | 15 | 6 | |
Proteasome Inhibitors | 51 | 33 |  |
Protein Kinase C Inhibitor | 1 | 1 | |
Protein Kinase Inhibitors | 17 | 13 |  |
Protein tyrosine phosphatase 1B (PTP1B) modulator | 4 | 2 | |
Proton Pump Inhibitor | 36 | 13 |  |
Psychedelic | 1 | 1 | |
Quinone Reductase-Inducer | 3 | 2 | |
Quorum Sensing Inhibition | 1 | 1 | |
Radiation-Protective Agents | 4 | 2 | |
Radiation-Sensitizing Agents | 1 | 1 | |
Radiopharmaceuticals | 1 | 1 | |
Radioprotective | 1247 | 406 |  |
Radiosensitizer | 244 | 142 |  |
RANK Downregulation | 1 | 1 | |
RANTES (CCL5) Inhibitor | 2 | 2 | |
Reactive Oxygen Species (ROS) attenuation | 1 | 1 | |
Receptor activator of NF-κB (RANK) gene expression | 2 | 2 | |
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor | 2 | 1 | |
Redox Balancer | 2 | 1 | |
Redox Modulator | 5 | 3 | |
Regenerative | 52 | 28 | |
Remyelination | 2 | 1 | |
Renoprotective | 1308 | 593 |  |
Respiratory System Agents | 10 | 1 | |
Reverse Transcriptase Inhibitors | 42 | 24 |  |
Ribonucleotide Reductase Inhibitor | 1 | 1 | |
S-phase kinase associated protein 2 inhibition | 1 | 1 | |
Sarcoplasmic Calcium ATPase Up-regulation | 2 | 1 | |
Schistosomicides | 2 | 1 | |
Scolicidal | 1 | 1 | |
Secretagogue | 178 | 38 |  |
Secretagogues: Prolactin Up-Regulation | 1 | 1 | |
Selective estrogen enzyme modulator (SEEM) | 11 | 8 | |
Selective Estrogen Receptor Modulators | 10 | 6 | |
Serine Proteinase Inhibitors | 1 | 1 | |
Serotonergic | 32 | 8 | |
Serotonin Agonists | 2 | 1 | |
Serum ceruloplasmin oxidase reducer | 2 | 1 | |
SGLT1 inducer | 4 | 2 | |
SGLT1 inducer | 4 | 2 | |
Sigma-1 Receptor Agonist | 2 | 2 | |
SIRT1 Activator | 39 | 23 | |
Spasmogenic | 2 | 1 | |
Spermatogenic | 12 | 2 | |
Spermicidal Activity | 5 | 1 | |
STAT3 Activation | 2 | 1 | |
STAT3 Inhibitor | 53 | 31 | |
STAT3-NFκB Signaling: downregulation | 1 | 1 | |
Stearoyl coenzyme A desaturase-1 modulator | 2 | 1 | |
Steroidogenesis | 3 | 2 | |
Stomachic | 2 | 1 | |
Sulfonation | 1 | 1 | |
Superoxide Dismutase Up-regulation | 1039 | 415 |  |
Superoxide Scavenger | 1 | 1 | |
Survival protein down-regulation | 3 | 2 | |
Survivin Down-Regulation | 15 | 13 | |
Telomerase Inhibitor | 55 | 35 |  |
Telomerase Upregulation | 102 | 28 |  |
Telomere Protective | 83 | 10 | |
Teratogens | 14 | 3 | |
Thermogenic | 57 | 9 | |
Thrombolytic | 4 | 2 | |
Thromboxane (TXB) Inhibitors | 5 | 4 | |
Thromboxane B2 Inhibitor | 2 | 2 | |
Tocolytic Agents | 11 | 2 | |
Topoisomerase I inhibitor | 1 | 1 | |
Topoisomerase II Inhibitor | 3 | 3 | |
TRAIL sensitizer | 3 | 2 | |
Transforming growth factor beta (TGF-β) inhibitor | 32 | 9 | |
Transforming growth factor beta (TGF-β) upregulation | 2 | 1 | |
Transient Receptor Potential Melastatin 2 Inhibition | 1 | 1 | |
Transient receptor potential vanilloid type-2 activation | 1 | 1 | |
Trypanocidal Agents | 2 | 2 | |
Trypsin Inhibitors | 2 | 1 | |
Tumor Necrosis Factor (TNF) Alpha Enhancer | 38 | 8 | |
Tumor Necrosis Factor (TNF) Alpha Inhibitor | 4357 | 1763 |  |
Tumor Necrosis Factor (TNF) Alpha Upregulation | 2 | 1 | |
Tumor Suppressor Protein p53 Upregulation | 480 | 343 |  |
Tumor Suppressor Protein p73 Upregulation | 3 | 2 | |
Tyrosinase Inhibition | 1 | 1 | |
Tyrosinase inhibitors | 4 | 4 | |
Uncoupling Agents | 2 | 1 | |
Uricosuric Agents | 2 | 1 | |
Uterotonic | 34 | 11 |  |
Vanilloid Receptor-1 Modulator | 2 | 2 | |
Vascular Cell Adhesion Molecule-1 Inhibitor | 117 | 30 |  |
Vascular Endothelial Growth Factor A Enhancer | 4 | 2 | |
Vascular Endothelial Growth Factor A Inhibitor | 132 | 71 |  |
Vascular Endothelial Growth Factor C Inhibitor | 2 | 1 | |
Vascular Endothelial Growth Factor D Inhibitor | 2 | 1 | |
Vascular Endothelial Growth Factor Inhibitors | 123 | 61 | |
Vascular Endothelial Growth Factor Regulator | 31 | 14 |  |
Vascular smooth muscle cell (VSMC) inhibitor | 7 | 5 | |
Vasodilator Agents | 347 | 74 |  |
Vasopressin Inhibitor | 12 | 2 | |
Vasoprotective | 21 | 9 | |
VEGFR3 inhibition | 12 | 3 | |
Viral Hemagglutinin Inhibitor | 18 | 14 |  |
Vitamin D Receptor (VDR) Modulator | 1 | 1 | |
Wnt/β-catenin pathway down-regulation | 49 | 27 | |
Wnt/β-catenin signaling pathway modulation | 36 | 24 | |
Wound Healing Effects | 10 | 1 | |
Xanthine oxidase inhibitor | 26 | 13 |  |
Zinc-dependent metalloproteinase inhibitor | 1 | 1 | |
β(2)-adrenoceptor up-regulation | 2 | 1 | |
β-secretase Inhibitor | 1 | 1 | |