Chemothapeutic Synergy: 5-flourouracil

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26 Diseases Researched for Chemothapeutic Synergy: 5-flourouracil
NameACCKFocus
Colon Cancer814Locked
Cancers: Drug Resistant813Locked
Colorectal Cancer812Locked
Gastric Cancer69Locked
Cancers: Multi-Drug Resistant37Locked
Cholangiocarcinoma15Locked
Liver Cancer45Locked
Oral Cancer45Locked
Cancers: All34Locked
Breast Cancer33Locked
Breast Cancer: Triple Negative 33Locked
Squamous cell carcinoma23Locked
Chemotherapy and Radiation Toxicity12Locked
Esophageal Cancer12Locked
Mucositis12Locked
Prostate Cancer22Locked
Adenoid cystic carcinoma (ACC)11Locked
Cervical Cancer11Locked
Head and Neck Cancer11Locked
Kidney Cancer11Locked
Laryngeal Cancer11Locked
Lung Cancer11Locked
Lymphoma11Locked
Osteosarcoma11Locked
Pancreatic Cancer11Locked
Skin Cancer11Locked
35 Substances Researched for Chemothapeutic Synergy: 5-flourouracil
NameACCKFocus
Curcumin57Locked
Mushrooms: All 26Locked
Capsaicin15Locked
Berberine33Locked
EGCG (Epigallocatechin gallate)23Locked
Thymoquinone23Locked
Vitamin D23Locked
Apple12Locked
Fucoxanthin 22Locked
Gynostemma12Locked
Honokiol12Locked
Lupeol12Locked
Quercetin12Locked
Shikonin12Locked
Vitamin C22Locked
Water12Locked
White Mulberry 12Locked
Astragaloside11Locked
Canthaxanthin11Locked
Chinese Skullcap 11Locked
Crocetin11Locked
Crocin11Locked
Garlic11Locked
Geraniol 11Locked
Gingerol 11Locked
Lactobacillus plantarum11Locked
Melatonin11Locked
Phellinus Linteus11Locked
Pterostilbene11Locked
Reishi Mushroom11Locked
Sulforaphane11Locked
Ursolic Acid11Locked
Vitamin A11Locked
Wogonin11Locked
beta-Carotene11Locked
3 Therapeutic Actions Researched for Chemothapeutic Synergy: 5-flourouracil
NameACCKFocus
Heat Therapy23Locked
Dietary Modification: Elemental Diet12Locked
Light-Emitting Diodes (LEDs) Therapy11Locked
32 Pharmacological Actions Researched for Chemothapeutic Synergy: 5-flourouracil
NameACCKFocus
Apoptotic1934Locked
Chemosensitizer2233Locked
Antiproliferative 1822Locked
Chemotherapeutic1116Locked
Cell cycle arrest59Locked
Antineoplastic Agents37Locked
Autophagy Inhibitors15Locked
Chemoprotective Agents35Locked
NF-kappaB Inhibitor35Locked
Bcl-2 protein down-regulation24Locked
Cyclooxygenase 2 Inhibitors24Locked
Wnt/β-catenin signaling pathway modulation24Locked
Anti-Inflammatory Agents23Locked
Survivin Down-Regulation23Locked
Vascular Endothelial Growth Factor Inhibitors23Locked
Anticarcinogenic Agents12Locked
Heat Shock Protein Down-Regulation12Locked
Immunomodulatory12Locked
MicroRNA modulator12Locked
Angiogenesis Inhibitors11Locked
Anti-metastatic11Locked
Autophagy Up-regulation11Locked
Bax/Bcl2 ratio: Increase11Locked
Bcl-xL down-regulation11Locked
Cyclin D1 Down-Regulation11Locked
Heat Shock Protein Inducer11Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor11Locked
Multidrug Resistance Gene Modulators11Locked
P21 Activation11Locked
STAT3 Inhibitor11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Wnt/β-catenin pathway down-regulation11Locked

View the Evidence:
66 Abstracts with Chemothapeutic Synergy: 5-flourouracil Research

[+]

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(5):e0121538. Epub 2015 May 1. PMID: 25933112
Article Published Date : Dec 31, 2014
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Capsaicin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Cholangiocarcinoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Autophagy Inhibitors, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genom Data. 2015 Sep 1 ;5:189-191. PMID: 26309812
Article Published Date : Aug 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Mushrooms: All
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Epigenetic Modification In Cancer, Gene Expression Regulation
[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Gene Expression Regulation
[+]

An apple oligogalactan enhances the growth inhibitory effect of 5-fluorouracil on colorectal cancer.Jun 04, 2017

Pubmed Data : Eur J Pharmacol. 2017 Jun 5 ;804:13-20. Epub 2017 Apr 5. PMID: 28389232
Article Published Date : Jun 04, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Ascorbic acid chemosensitizes colorectal cancer cells and synergistically inhibits tumor growth.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2018 ;9:911. Epub 2018 Jul 23. PMID: 30083105
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin
[+]

Curcumin combined with 5-FU led to the lower cell viability and higher apoptosis than 5-FU treated alone.Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2012 Oct ;44(10):847-55. PMID: 23017833
Article Published Date : Sep 30, 2012
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo.Dec 31, 2015

Pubmed Data : Oncol Res. 2016 ;23(1):29-34. PMID: 26802648
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin
[+]

Deguelin may represent a novel and effective chemo-agent against head and neck squamous cell carcinoma.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(1):e54736. Epub 2013 Jan 23. PMID: 23372762
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Deguelin
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Dietary ellagitannins from pomegranate could alleviate intestinal mucositis in rats induced by 5-FU.Jun 18, 2018

Pubmed Data : J Agric Food Chem. 2018 Jun 19. Epub 2018 Jun 19. PMID: 29920075
Article Published Date : Jun 18, 2018
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil , Colorectal Cancer
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

EGCG enhances 5FU sensitivity in chemoresistant colorectal cancer by targeting cancer stem cells.Mar 28, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Mar 29 ;7(13):16158-71. PMID: 26930714
Article Published Date : Mar 28, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer, MicroRNA modulator
Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: 5-flourouracil
[+]

Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer.Apr 23, 2019

Pubmed Data : Int J Cancer. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31018249
Article Published Date : Apr 23, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2018 Jan ;52(1):127-138. Epub 2017 Nov 1. PMID: 29115601
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Colorectal Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative
Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin
[+]

Gynostemma pentaphyllum saponins could enhance the anti-cancer efficacy of 5-FU.Dec 31, 2015

Pubmed Data : Proteomics. 2016 05 ;16(10):1557-69. Epub 2016 Apr 28. PMID: 26970558
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Gynostemma
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

High-content hydrogen water can inhibit colon cancer, particularly in combination with 5-fluorouracil.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2015 ;3:e859. Epub 2015 Apr 7. PMID: 25870767
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Water
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Honokiol and 5-FU exert a synergistic therapeutic effect on oral squamous cell carcinoma by inducing apoptosis.Jul 27, 2016

Pubmed Data : J Oral Pathol Med. 2016 Jul 28. Epub 2016 Jul 28. PMID: 27465776
Article Published Date : Jul 27, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells.Apr 30, 2016

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2016 May ;389(5):477-84. Epub 2016 Feb 19. PMID: 26892272
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Survivin Down-Regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

M. alba L. fruit extract might be a potential anti-tumor immunomodulatory candidate chemotherapy agent.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2015 ;16(10):24139-58. Epub 2015 Oct 13. PMID: 26473845
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : White Mulberry
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic, Immunomodulatory
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Quercetin inhibited the tumor growth and enhanced the 5-fluorouracil (5-FU) therapeutic efficacy in vitro and in vivo.Nov 30, 2015

Pubmed Data : Tumour Biol. 2015 Dec 1. Epub 2015 Dec 1. PMID: 26628295
Article Published Date : Nov 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Liver Cancer
Therapeutic Actions : Heat Therapy
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Shikonin enhances the chemotherapeutic sensitivity of gastric cancer cells to 5-fluorouracil and oxaliplatin.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Dec 1 ;6:38267. Epub 2016 Dec 1. PMID: 27905569
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin
[+]

The elemental diet may be effective for the prevention of antineoplastic chemotherapy-induced mucositis.Jul 31, 2015

Pubmed Data : Cancer Chemother Pharmacol. 2015 Aug ;76(2):269-77. Epub 2015 Jun 6. PMID: 26048344
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy and Radiation Toxicity, Mucositis
Therapeutic Actions : Dietary Modification: Elemental Diet
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

This study revealed that cotreatment of cardamonin and 5-FU could strongly potentiate the antitumor activity of 5-FU.May 16, 2019

Pubmed Data : Invest New Drugs. 2019 May 17. Epub 2019 May 17. PMID: 31102118
Article Published Date : May 16, 2019
Study Type : Animal Study
Additional Links
Substances : Cardamonin
Diseases : Gastric Cancer
Pharmacological Actions : Chemosensitizer, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949
Article Published Date : Jul 24, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

5-FU in combination with berberine or curcumin showed a synergistic inhibition of survivin and STAT3 level resulting in enhanced cell death in gastric cancer cells.Oct 21, 2015

Pubmed Data : Nutr Cancer. 2015 Oct 22:1-12. Epub 2015 Oct 22. PMID: 26492225
Article Published Date : Oct 21, 2015
Study Type : In Vitro Study
Additional Links
Substances : Berberine, Curcumin
Diseases : Gastric Cancer
Pharmacological Actions : STAT3 Inhibitor, Survivin Down-Regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Natural Substance Synergy
[+]

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28249781
Article Published Date : Feb 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel
[+]

Anticancer and antimigration effects of a combinatorial treatment of 5-fluorouracil and Lactobacillus paracasei.Jun 05, 2018

Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5549-5555. Epub 2018 May 22. PMID: 29737161
Article Published Date : Jun 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus paracasei, Milk: Fermented
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Anticancer effects of seaweed compound fucoxanthin alone and in combination with 5-fluorouracil in colon cells.Aug 28, 2017

Pubmed Data : J Toxicol Environ Health A. 2017 Aug 29:1-12. Epub 2017 Aug 29. PMID: 28850007
Article Published Date : Aug 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoxanthin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs.Apr 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Chemother Pharmacol. 2011 May ;67(5):1157-66. Epub 2010 Aug 8. PMID: 20694726
Article Published Date : Apr 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Docetaxel
[+]

Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil.May 31, 2017

Pubmed Data : J Pharm Pharmacol. 2017 Jun ;69(6):743-752. Epub 2017 Mar 7. PMID: 28266023
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Cancers: Drug Resistant, Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Beta-elemene increases chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.Jul 31, 2018

Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):7032-7039. Epub 2018 May 8. PMID: 29737579
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas.Aug 03, 2018

Pubmed Data : Med Oncol. 2018 Aug 4 ;35(9):124. Epub 2018 Aug 4. PMID: 30078069
Article Published Date : Aug 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Head and Neck Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Cardamonin reduces chemotherapy resistance of colon cancer cells.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Jun ;15(6):9641-9646. Epub 2018 Apr 26. PMID: 29928339
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cardamonin
Diseases : Cancers: Drug Resistant, Colon Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Chemoresistance to 5-FU was inhibited by 635 nm LED irradiation in CD133+ KB cell line.Sep 26, 2017

Pubmed Data : Lasers Med Sci. 2017 Sep 27. Epub 2017 Sep 27. PMID: 28956217
Article Published Date : Sep 26, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: Drug Resistant, Oral Cancer
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0139298. Epub 2015 Sep 30. PMID: 26421434
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Colon Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Dose Response, Natural Substance/Drug Synergy
[+]

Combination of 5-fluorouracil, 13-cis retinoic acid and vitamin D3 has more inhibitory effect on cell proliferation and apoptotic effect than one of these drugs.Apr 30, 2012

Pubmed Data : J Contemp Dent Pract. 2012 May-Jun;13(3):345-50. Epub 2012 May 1. PMID: 22918008
Article Published Date : Apr 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Vitamin A, Vitamin D
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Crocetin may increase autophagic cell death in fluorouracil-treated breast cancer cells.Feb 28, 2017

Pubmed Data : Tumour Biol. 2017 Mar ;39(3):1010428317694536. PMID: 28351329
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Curcumin demonstrates promising therapeutic potential as a new treatment modality for head and neck cancer management.Oct 26, 2015

Pubmed Data : ACS Comb Sci. 2015 Oct 27. Epub 2015 Oct 27. PMID: 26505786
Article Published Date : Oct 26, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin
[+]

Curcumin potentiates and chemosensitizes HCT116R cells to 5-FU-based chemotherapyDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2015 ;15:250. Epub 2015 Apr 10. PMID: 25884903
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Drug Resistant Cancer, Tumor Microenvironment
[+]

Curcumin was significantly more effective than 5-FU in all three cell lines.Jan 15, 2019

Pubmed Data : Anticancer Agents Med Chem. 2019 Jan 16. Epub 2019 Jan 16. PMID: 30652650
Article Published Date : Jan 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: 5-flourouracil, Superiority of Natural Substances versus Drugs
[+]

Deuterium depleted water inhibits the proliferation of human MCF7 breast cancer cell lines by inducing cell cycle arrest.Dec 31, 2018

Pubmed Data : Nutr Cancer. 2019 ;71(6):1019-1029. Epub 2019 May 2. PMID: 31045450
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

EGCG inhibits gastric cancer growth and reverses 5-FU resistance in gastric cancer cells.Oct 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Oct 10 ;8(47):82842-82853. Epub 2017 Sep 6. PMID: 29137307
Article Published Date : Oct 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cancers: Drug Resistant, Gastric Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Fucoxanthin combined with other drugs could enhance the effect of both fucoxanthin and the other drug or reduce the dose without reducing the effect.Jan 08, 2019

Pubmed Data : J Cancer Res Clin Oncol. 2019 Jan 9. Epub 2019 Jan 9. PMID: 30627824
Article Published Date : Jan 08, 2019
Study Type : Review
Additional Links
Substances : Fucoxanthin
Diseases : Cancers: All
Pharmacological Actions : Anti-Angiogenic, Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Imatinib
[+]

Ganoderma lucidum polysaccharides show prominent anticancer activities by reactivating several types of mutant p53.Dec 31, 2016

Pubmed Data : Oncol Rep. 2017 Jan ;37(1):594-600. Epub 2016 Nov 15. PMID: 27878254
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Colorectal Cancer
Pharmacological Actions : Chemotherapeutic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Polysaccharides, Reactivation Of Tumor Suppressor Gene
[+]

Geraniol can constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2016 May ;48(5):1772-82. Epub 2016 Mar 9. PMID: 26983575
Article Published Date : Apr 30, 2016
Study Type : Review
Additional Links
Substances : Geraniol
Diseases : Breast Cancer, Cancers: All, Cancers: Drug Resistant, Colon Cancer, Kidney Cancer, Liver Cancer, Lung Cancer, Oral Cancer, Pancreatic Cancer, Prostate Cancer, Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin
[+]

Grape seed extract significantly enhanced the growth-inhibitory effects of 5-Fluorouracil by 26%.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(1):e85184. Epub 2014 Jan 21. PMID: 24465501
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Colon Cancer, Mucositis
Pharmacological Actions : Antioxidants, Antiproliferative , Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

High dose of vitamin C in combination with 5-FU chemotherapy enhances the chemoresponsiveness of cancer cells.Apr 30, 2003

Pubmed Data : In Vivo. 2003 May-Jun;17(3):289-92. PMID: 12929582
Article Published Date : Apr 30, 2003
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Cancers: Multi-Drug Resistant, Liver Cancer, Lymphoma
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Hyperthermia combined with 5-fluorouracil had a synergistic effect in promoting apoptosis and enhancing thermotolerance in gastric cancer cells. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2015 ;8:1265-70. Epub 2015 May 27. PMID: 26064061
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Diseases : Gastric Cancer
Therapeutic Actions : Heat Therapy
Pharmacological Actions : Apoptotic, Bcl-xL down-regulation, Heat Shock Protein Inducer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro.Mar 31, 2019

Pubmed Data : J Food Biochem. 2019 Apr ;43(4):e12802. Epub 2019 Feb 11. PMID: 31353575
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Lycopene, Quercetin, Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Cisplatin, Natural Substance Synergy
[+]

Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells.Jul 25, 2018

Pubmed Data : Free Radic Biol Med. 2018 Jul 26 ;126:41-54. Epub 2018 Jul 26. PMID: 30056083
Article Published Date : Jul 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Manuka Honey
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Chemopreventive, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Melatonin synergized the chemotherapeutic effect of 5-FU in colon cancer through simultaneous suppression of multiple signalling pathways.Nov 18, 2016

Pubmed Data : J Pineal Res. 2016 Nov 19. Epub 2016 Aug 19. PMID: 27865009
Article Published Date : Nov 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Colon Cancer
Pharmacological Actions : Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Phellinus linteus extracts synergized with low doses of 5-FU to inhibit triple-negative breast cancer cell growth.Dec 31, 2014

Pubmed Data : Nutr Cancer. 2015 ;67(2):275-84. Epub 2015 Jan 26. PMID: 25622112
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mushrooms: All , Phellinus Linteus
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Autophagy Up-regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Dose Response, Plant Extracts
[+]

Pre-treatment with berberine enhances effect of 5-fluorouracil and cisplatin in HEP2 laryngeal cancer cell line.Dec 31, 2017

Pubmed Data : J Biol Regul Homeost Agents. 2018 Jan-Feb;32(2 Suppl. 1):167-177. PMID: 29460537
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Laryngeal Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Cisplatin
[+]

Probiotic substances may be useful therapeutic alternatives as biotherapeutics for chemo-resistant colorectal cancer.May 24, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2016 May 25. Epub 2016 May 25. PMID: 27221111
Article Published Date : May 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus plantarum
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Chemosensitizer, Wnt/β-catenin pathway down-regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Drug Resistant Cancer Stem Cells
[+]

Pterostilbene synergizes the cytotoxic effects of 5-FU in Caco-2 colon cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:15239. Epub 2015 Oct 16. PMID: 26472352
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Colon Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Red American ginseng may have clinical utility to decrease the dosage of 5-FU in colorectal cancer therapeutics.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Appl Biomed. 2018 Nov ;16(4):311-319. Epub 2018 May 31. PMID: 30976156
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (American)
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic, Paraptosis
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells.Mar 31, 2018

Pubmed Data : Phytomedicine. 2018 Apr 1 ;43:37-45. Epub 2018 Mar 19. PMID: 29747752
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Doxorubicin
[+]

Reversing resistance of multidrug-resistant hepatic carcinoma cells with parthenolide.Mar 31, 2013

Pubmed Data : Future Oncol. 2013 Apr ;9(4):595-604. PMID: 23560381
Article Published Date : Mar 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Cancers: Drug Resistant, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, Chemotherapeutic, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Rosmarinic acid enhances chemosensitivity of resistant gastric carcinoma SGC7901 cells to 5-flourouracil.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:2327-2334. Epub 2018 Nov 30. PMID: 30551491
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Cancers: Drug Resistant, Gastric Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Sulforaphane and 5-fluorouracil act synergistically in the MDA-MB-231 cells.Nov 01, 2017

Pubmed Data : Food Chem Toxicol. 2017 Nov 2 ;111:1-8. Epub 2017 Nov 2. PMID: 29104175
Article Published Date : Nov 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer.Jul 27, 2013

Pubmed Data : Cancer Lett. 2013 Jul 28 ;335(2):479-86. Epub 2013 Mar 16. PMID: 23507557
Article Published Date : Jul 27, 2013
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

The effect of garlic oil combined with 5-FU on ACC-M cells was stronger than the garlic oil, 5-FU used alone.Jan 31, 2014

Pubmed Data : Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Feb ;28(3):175-7, 181. PMID: 24826454
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Garlic
Diseases : Adenoid cystic carcinoma (ACC)
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

The results indicate that ellagic acid has potential as a novel agent sensitizing colorectal cancer cells to 5-fluorouracil.Sep 30, 2012

Pubmed Data : Anticancer Res. 2012 Oct ;32(10):4413-8. PMID: 23060566
Article Published Date : Sep 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

These results confirm the potential of gold nanoparticles to enhance 5-FU anticancer efficacy.Nov 19, 2016

Pubmed Data : Int J Pharm. 2016 Nov 20 ;513(1-2):648-658. Epub 2016 Sep 29. PMID: 27693737
Article Published Date : Nov 19, 2016
Study Type : In Vitro Study
Additional Links
Substances : Gold (nanoparticles)
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

This study implies that carotenoids may be utilised as chemosensitisers.Aug 14, 2012

Pubmed Data : Phytomedicine. 2012 Aug 15 ;19(11):977-87. Epub 2012 Jul 4. PMID: 22770743
Article Published Date : Aug 14, 2012
Study Type : In Vitro Study
Additional Links
Substances : beta-Carotene, Canthaxanthin, Crocin, Fucoxanthin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Vinblastine
[+]

Thymoquinone is able to inhibit cell proliferation, and induce apoptosis of human osteosarcoma MG-63 cells.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Apr ;20(7):1263-70. PMID: 27097945
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemoprotective Agents, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Ursolic acid exerted chemosensitizing effects in colon cancer cells.Aug 31, 2016

Pubmed Data : J Zhejiang Univ Sci B. 2016 Sep ;17(9):672-82. PMID: 27604859
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Colon Cancer
Pharmacological Actions : Chemosensitizer, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Multidrug Resistance Gene Modulators, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin
[+]

Wogonin has a synergistic effect with 5-fluorouracil, etoposide, and adriamycin to enhance chemotherapy and reverse drug resistance.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2016 ;9:2935-43. Epub 2016 May 17. PMID: 27274287
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Natural Substance/Drug Synergy

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