Chemothapeutic Synergy: 5-flourouracil

Name	AC	CK
Colon Cancer	8	14
Cancers: Drug Resistant	8	13
Colorectal Cancer	8	12
Gastric Cancer	6	9
Cancers: Multi-Drug Resistant	3	7
Cholangiocarcinoma	1	5
Liver Cancer	4	5
Oral Cancer	4	5
Cancers: All	3	4
Breast Cancer	3	3
Breast Cancer: Triple Negative	3	3
Squamous cell carcinoma	2	3
Chemotherapy and Radiation Toxicity	1	2
Esophageal Cancer	1	2
Mucositis	1	2
Prostate Cancer	2	2
Adenoid cystic carcinoma (ACC)	1	1
Cervical Cancer	1	1
Head and Neck Cancer	1	1
Kidney Cancer	1	1
Laryngeal Cancer	1	1
Lung Cancer	1	1
Lymphoma	1	1
Osteosarcoma	1	1
Pancreatic Cancer	1	1
Skin Cancer	1	1

Name	AC	CK
Curcumin	5	7
Mushrooms: All	2	6
Capsaicin	1	5
Berberine	3	3
EGCG (Epigallocatechin gallate)	2	3
Thymoquinone	2	3
Vitamin D	2	3
Apple	1	2
Fucoxanthin	2	2
Gynostemma	1	2
Honokiol	1	2
Lupeol	1	2
Quercetin	1	2
Shikonin	1	2
Vitamin C	2	2
Water	1	2
White Mulberry	1	2
Astragaloside	1	1
Canthaxanthin	1	1
Chinese Skullcap	1	1
Crocetin	1	1
Crocin	1	1
Garlic	1	1
Geraniol	1	1
Gingerol	1	1
Lactobacillus plantarum	1	1
Melatonin	1	1
Phellinus Linteus	1	1
Pterostilbene	1	1
Reishi Mushroom	1	1
Sulforaphane	1	1
Ursolic Acid	1	1
Vitamin A	1	1
Wogonin	1	1
beta-Carotene	1	1

Name	AC	CK
Heat Therapy	2	3
Dietary Modification: Elemental Diet	1	2
Light-Emitting Diodes (LEDs) Therapy	1	1

Name	AC	CK
Apoptotic	19	34
Chemosensitizer	22	33
Antiproliferative	18	22
Chemotherapeutic	11	16
Cell cycle arrest	5	9
Antineoplastic Agents	3	7
Autophagy Inhibitors	1	5
Chemoprotective Agents	3	5
NF-kappaB Inhibitor	3	5
Bcl-2 protein down-regulation	2	4
Cyclooxygenase 2 Inhibitors	2	4
Wnt/β-catenin signaling pathway modulation	2	4
Anti-Inflammatory Agents	2	3
Survivin Down-Regulation	2	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Anticarcinogenic Agents	1	2
Heat Shock Protein Down-Regulation	1	2
Immunomodulatory	1	2
MicroRNA modulator	1	2
Angiogenesis Inhibitors	1	1
Anti-metastatic	1	1
Autophagy Up-regulation	1	1
Bax/Bcl2 ratio: Increase	1	1
Bcl-xL down-regulation	1	1
Cyclin D1 Down-Regulation	1	1
Heat Shock Protein Inducer	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
P21 Activation	1	1
STAT3 Inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Wnt/β-catenin pathway down-regulation	1	1

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Pubmed Data : J Agric Food Chem. 2018 Jun 19. Epub 2018 Jun 19. PMID: 29920075

Article Published Date : Jun 18, 2018

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil , Colorectal Cancer

Pharmacological Actions : Chemoprotective Agents, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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EGCG enhances 5FU sensitivity in chemoresistant colorectal cancer by targeting cancer stem cells.Mar 28, 2016

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Honokiol and 5-FU exert a synergistic therapeutic effect on oral squamous cell carcinoma by inducing apoptosis.Jul 27, 2016

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Pubmed Data : J Oral Pathol Med. 2016 Jul 28. Epub 2016 Jul 28. PMID: 27465776

Article Published Date : Jul 27, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Apoptotic

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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Lactobacillus rhamnosus enhances the immunological antitumor effect of 5-fluorouracil against colon cancer.Dec 31, 2018

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Pubmed Data : Tumour Biol. 2015 Dec 1. Epub 2015 Dec 1. PMID: 26628295

Article Published Date : Nov 30, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Liver Cancer

Therapeutic Actions : Heat Therapy

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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Shikonin enhances the chemotherapeutic sensitivity of gastric cancer cells to 5-fluorouracil and oxaliplatin.Nov 30, 2016

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Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma.Oct 28, 2019

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Pubmed Data : Med Oncol. 2019 Oct 29 ;36(12):97. Epub 2019 Oct 29. PMID: 31664534

Article Published Date : Oct 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Caffeine

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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Cardamonin reduces chemotherapy resistance of colon cancer cells.May 31, 2018

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Pubmed Data : J Contemp Dent Pract. 2012 May-Jun;13(3):345-50. Epub 2012 May 1. PMID: 22918008

Article Published Date : Apr 30, 2012

Study Type : In Vitro Study

Additional Links

Substances : Vitamin A, Vitamin D

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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Cost effective use of a thiosulfinate-enriched Allium sativum extract in combination with chemotherapy in colon cancer.Apr 15, 2020

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EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines.Jan 14, 2020

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Pubmed Data : Arch Biochem Biophys. 2020 10 15 ;692:108546. Epub 2020 Aug 18. PMID: 32818507

Article Published Date : Jan 14, 2020

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Colon Cancer, Lung Cancer, Pancreatic Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine

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Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine.Dec 31, 2019

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Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells.Dec 31, 2020

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Pubmed Data : Sci Rep. 2015 ;5:15239. Epub 2015 Oct 16. PMID: 26472352

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Pterostilbene

Diseases : Colon Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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Red American ginseng may have clinical utility to decrease the dosage of 5-FU in colorectal cancer therapeutics.Oct 31, 2018

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Pubmed Data : Anticancer Res. 2012 Oct ;32(10):4413-8. PMID: 23060566

Article Published Date : Sep 30, 2012

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid

Diseases : Cancers: Drug Resistant, Colorectal Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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The synergistic Antitumor effect of 5-fluorouracil combined with allicin against lung and colorectal carcinoma cells.Apr 21, 2020

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Pubmed Data : J Zhejiang Univ Sci B. 2016 Sep ;17(9):672-82. PMID: 27604859

Article Published Date : Aug 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Colon Cancer

Pharmacological Actions : Chemosensitizer, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Multidrug Resistance Gene Modulators, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin

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Wogonin has a synergistic effect with 5-fluorouracil, etoposide, and adriamycin to enhance chemotherapy and reverse drug resistance.Dec 31, 2015

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Pubmed Data : Onco Targets Ther. 2016 ;9:2935-43. Epub 2016 May 17. PMID: 27274287

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Chinese Skullcap , Wogonin

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Natural Substance/Drug Synergy

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β-elemene reverses the resistance of p53-deficient colorectal cancer cells to 5-fluorouracil.Dec 31, 2019

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Pubmed Data : Front Bioeng Biotechnol. 2020 ;8:378. Epub 2020 May 8. PMID: 32457882

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Colorectal Cancer

Pharmacological Actions : Autophagy Up-regulation, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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View the Evidence: 101 Abstracts with Chemothapeutic Synergy: 5-flourouracil Research

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Calebin A potentiates the effect of 5-FU and TNF-β against human colorectal cancer cells.Mar 30, 2020

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Promising cytotoxic activity profile of fermented wheat germ extract in human cancer cell lines.Apr 15, 2011

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

An apple oligogalactan enhances the growth inhibitory effect of 5-fluorouracil on colorectal cancer.Jun 04, 2017

Ascorbic acid chemosensitizes colorectal cancer cells and synergistically inhibits tumor growth.Dec 31, 2017

Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma.Jan 25, 2020

Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus.Feb 29, 2012

Curcumin combined with 5-FU led to the lower cell viability and higher apoptosis than 5-FU treated alone.Sep 30, 2012

Curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo.Dec 31, 2015

Deguelin may represent a novel and effective chemo-agent against head and neck squamous cell carcinoma.Dec 31, 2012

Dietary ellagitannins from pomegranate could alleviate intestinal mucositis in rats induced by 5-FU.Jun 18, 2018

EGCG enhances 5FU sensitivity in chemoresistant colorectal cancer by targeting cancer stem cells.Mar 28, 2016

Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer.Apr 23, 2019

Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer.Aug 31, 2019

Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo.Dec 31, 2017

Gynostemma pentaphyllum saponins could enhance the anti-cancer efficacy of 5-FU.Dec 31, 2015

Hericium erinaceus could promote the antitumor efficacy of 5-Fu by improving the microbiota composition, the immune inflammatory response, and homeostasis.May 26, 2020

High-content hydrogen water can inhibit colon cancer, particularly in combination with 5-fluorouracil.Dec 31, 2014

Honokiol and 5-FU exert a synergistic therapeutic effect on oral squamous cell carcinoma by inducing apoptosis.Jul 27, 2016

Lactobacillus rhamnosus enhances the immunological antitumor effect of 5-fluorouracil against colon cancer.Dec 31, 2018

Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells.Apr 30, 2016

Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced solid ehrlich carcinomaAug 31, 2019

M. alba L. fruit extract might be a potential anti-tumor immunomodulatory candidate chemotherapy agent.Dec 31, 2014

Quercetin inhibited the tumor growth and enhanced the 5-fluorouracil (5-FU) therapeutic efficacy in vitro and in vivo.Nov 30, 2015

Shikonin enhances the chemotherapeutic sensitivity of gastric cancer cells to 5-fluorouracil and oxaliplatin.Nov 30, 2016

Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma.Jan 31, 2010

The elemental diet may be effective for the prevention of antineoplastic chemotherapy-induced mucositis.Jul 31, 2015

This study revealed that cotreatment of cardamonin and 5-FU could strongly potentiate the antitumor activity of 5-FU.May 16, 2019

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death.Sep 30, 2018

ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells.Jan 03, 2019

5-FU in combination with berberine or curcumin showed a synergistic inhibition of survivin and STAT3 level resulting in enhanced cell death in gastric cancer cells.Oct 21, 2015

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

6-shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells.May 10, 2020

Anticancer and antimigration effects of a combinatorial treatment of 5-fluorouracil and Lactobacillus paracasei.Jun 05, 2018

Anticancer effect of 5-fluorouracil combined with extract of Rosa roxburghii Tratt on human endometrial adenocarcinoma.Jul 31, 2011

Anticancer effects of seaweed compound fucoxanthin alone and in combination with 5-fluorouracil in colon cells.Aug 28, 2017

Antiproliferation and apoptosis induction of paeonol in HepG2 cells.Jan 13, 2007

Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells.Mar 31, 2008

Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells.Feb 28, 2017

Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs.Apr 30, 2011

Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil.May 31, 2017

Beta-elemene enhances the chemotherapeutic effect of 5-fluorouracil in triple-negative breast cancer.Dec 31, 2019

Beta-elemene increases chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.Jul 31, 2018

Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas.Aug 03, 2018

Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells.Apr 30, 2018

Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma.Oct 28, 2019

Cardamonin reduces chemotherapy resistance of colon cancer cells.May 31, 2018

Carvacrol exhibits chemopreventive potential against cervical cancer cells.Dec 29, 2020

Chemoresistance to 5-FU was inhibited by 635 nm LED irradiation in CD133+ KB cell line.Sep 26, 2017

Co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents.Dec 31, 2014

Combination of 5-fluorouracil, 13-cis retinoic acid and vitamin D3 has more inhibitory effect on cell proliferation and apoptotic effect than one of these drugs.Apr 30, 2012

Cost effective use of a thiosulfinate-enriched Allium sativum extract in combination with chemotherapy in colon cancer.Apr 15, 2020

Crocetin may increase autophagic cell death in fluorouracil-treated breast cancer cells.Feb 28, 2017

Curcumin demonstrates promising therapeutic potential as a new treatment modality for head and neck cancer management.Oct 26, 2015

Curcumin potentiates and chemosensitizes HCT116R cells to 5-FU-based chemotherapyDec 31, 2014

Curcumin was significantly more effective than 5-FU in all three cell lines.Jan 15, 2019

Deuterium depleted water inhibits the proliferation of human MCF7 breast cancer cell lines by inducing cell cycle arrest.Dec 31, 2018

EGCG inhibits gastric cancer growth and reverses 5-FU resistance in gastric cancer cells.Oct 09, 2017

EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines.Jan 14, 2020

Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine.Dec 31, 2019

Fucoxanthin combined with other drugs could enhance the effect of both fucoxanthin and the other drug or reduce the dose without reducing the effect.Jan 08, 2019

Ganoderma lucidum polysaccharides show prominent anticancer activities by reactivating several types of mutant p53.Dec 31, 2016

Geraniol can constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs.Apr 30, 2016

Grape seed extract significantly enhanced the growth-inhibitory effects of 5-Fluorouracil by 26%.Dec 31, 2013

High dose of vitamin C in combination with 5-FU chemotherapy enhances the chemoresponsiveness of cancer cells.Apr 30, 2003

Honokiol is a potential therapeutic agent and has a synergistic effect with 5-FU in human urothelial cell carcinoma cells.Nov 30, 2019

Hyperthermia combined with 5-fluorouracil had a synergistic effect in promoting apoptosis and enhancing thermotolerance in gastric cancer cells. Dec 31, 2014

Lactoferrin nanoparticle mediated targeted delivery of 5-fluorouracil for enhanced therapeutic efficacy.Jan 31, 2017

Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro.Mar 31, 2019

Chemothapeutic Synergy: 5-flourouracil

View the Evidence:
101 Abstracts with Chemothapeutic Synergy: 5-flourouracil Research