Chemothapeutic Synergy: Paclitaxel

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30 Diseases Researched for Chemothapeutic Synergy: Paclitaxel
NameACCKFocus
Breast Cancer1113Locked
Breast Cancer: Triple Negative 78Locked
Lung Cancer56Locked
Cervical Cancer45Locked
Carcinoma: Non-Small-Cell Lung34Locked
Glioma24Locked
Cancers: All33Locked
Gastric Cancer23Locked
Kidney Cancer33Locked
Ovarian Cancer23Locked
Prostate Cancer23Locked
Bladder Cancer12Locked
Cancers: Multi-Drug Resistant22Locked
Chemotherapy-Induced Toxicity: Tamoxifen12Locked
Colon Cancer22Locked
Ehrlich carcinoma12Locked
Liver Cancer22Locked
Pancreatic Cancer22Locked
Thyroid Cancer12Locked
Acute Myeloid Leukemia11Locked
Bone Cancer11Locked
Breast Cancer Stem Cells11Locked
Cancer Metastasis11Locked
Cancers: Drug Resistant11Locked
Choriocarcinoma11Locked
Colorectal Cancer11Locked
Glioblastoma11Locked
Non-Small-Cell Lung Carcinoma11Locked
Oral Cancer11Locked
Skin Cancer11Locked
30 Substances Researched for Chemothapeutic Synergy: Paclitaxel
NameACCKFocus
Curcumin78Locked
Ginsenosides23Locked
Modified Arabinoxylan Rice Bran (MGN-3)23Locked
Nobiletin 23Locked
Bamboo12Locked
Berbamine12Locked
Cannabinoids 12Locked
Cannabinoids: Synthetic12Locked
Flavonoids12Locked
Ginseng (Korean)12Locked
Honokiol22Locked
Mulberry12Locked
Thymoquinone22Locked
Tomato12Locked
Vitamin C12Locked
Wogonin12Locked
Alpha-Lipoic Acid11Locked
Berberine11Locked
Crocin11Locked
Cucurbitacin B 11Locked
Ellagic Acid11Locked
Fermented Foods and Beverages11Locked
Fisetin11Locked
Folic Acid 11Locked
Geraniol 11Locked
Gingerol 11Locked
Luteolin11Locked
Nettle11Locked
Panax Ginseng11Locked
Sulforaphane11Locked
2 Therapeutic Actions Researched for Chemothapeutic Synergy: Paclitaxel
NameACCKFocus
Heat Therapy11Locked
Ultrasound therapy11Locked
24 Pharmacological Actions Researched for Chemothapeutic Synergy: Paclitaxel
NameACCKFocus
Apoptotic2028Locked
Antiproliferative 1419Locked
Chemosensitizer1619Locked
Chemotherapeutic810Locked
NF-kappaB Inhibitor57Locked
Cell cycle arrest46Locked
Antineoplastic Agents35Locked
Bcl-2 protein down-regulation24Locked
Anti-metastatic33Locked
Chemopreventive23Locked
Anti-Inflammatory Agents22Locked
Cannabinoid Receptor Antagonist/Inverse Agonist12Locked
Multidrug Resistance Gene Modulators22Locked
PI3K-AKT inhibitor12Locked
Radiosensitizer22Locked
Bax/Bcl2 ratio: Increase11Locked
Caspase-3 Activation11Locked
Cyclooxygenase 2 Inhibitors11Locked
Heat Shock Protein Down-Regulation11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
P21 Activation11Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Vascular Endothelial Growth Factor Inhibitors11Locked

View the Evidence:
70 Abstracts with Chemothapeutic Synergy: Paclitaxel Research

[+]

Bamboo concentrate enhances the bioavailability of the chemotherapy agent paclitaxel. Nov 01, 2010

Pubmed Data : Radiat Res. 2010 Nov;174(5):624-36. Epub 2010 Sep 13. PMID: 15918522
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Bamboo
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Berbamine has synergistic antitumor effects with paclitaxel in glioma cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:8152526. Epub 2017 Aug 13. PMID: 28883885
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Berbamine
Diseases : Glioma
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Caffeic acid inhibited non-small-cell lung cancer cell growth by inducing apoptosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;48(4):1433-1442. Epub 2018 Jul 31. PMID: 30064123
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Caffeic Acid
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Pubmed Data : Planta Med. 2014 Apr ;80(6):452-7. Epub 2014 Mar 31. PMID: 24687742
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Drug: Carboplatin, Natural Substance/Drug Synergy, Plant Extracts
[+]

Curcumin and vitamin D3 enhanced the tumor response to paclitaxel.Oct 15, 2019

Pubmed Data : Chem Biol Interact. 2019 Oct 16 ;315:108865. Epub 2019 Oct 16. PMID: 31628941
Article Published Date : Oct 15, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin, Vitamin D
Diseases : Breast Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Curcumin is a potent chemosensitizer to improve the therapeutic index of paclitaxel.Jul 13, 2011

Pubmed Data : Oncogene. 2011 Jul 14 ;30(28):3139-52. Epub 2011 Feb 14. PMID: 21317920
Article Published Date : Jul 13, 2011
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo.Feb 01, 2017

Pubmed Data : J Control Release. 2017 Feb 2. Epub 2017 Feb 2. PMID: 28163212
Article Published Date : Feb 01, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Breast Cancer, Glioma
Additional Keywords : Breast Cancer, Chemothapeutic Synergy: Paclitaxel, Glioma, Vitamin C
[+]

Flavopiridol and paclitaxel exerted synergistic cytotoxic activities against SKOV3 cells in vitro and significantly suppress the tumor growth of mice bearing SKOV3 cells.Dec 31, 2014

Pubmed Data : Arch Gynecol Obstet. 2015 Jan ;291(1):143-50. Epub 2014 Aug 14. PMID: 25118834
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Ginsenoside Rg3 promotes cytotoxicity and apoptosis of Paclitaxel by inhibiting NF-κB signalling.Feb 19, 2017

Pubmed Data : Biomed Pharmacother. 2017 Feb 20 ;89:227-232. Epub 2017 Feb 20. PMID: 28231544
Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):3465-3477. PMID: 31432702
Article Published Date : Nov 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ligustrazine
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-metastatic, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Korean red ginseng extract enhances paclitaxel distribution to mammary tumors.May 16, 2016

Pubmed Data : Xenobiotica. 2016 May 17:1-10. Epub 2016 May 17. PMID: 27189791
Article Published Date : May 16, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Bioavailability, Chemothapeutic Synergy: Paclitaxel, Plant Extracts
[+]

MGN-3 supplementation enhances tumor cell demise in the presence of a low dose of paclitaxel.Jun 30, 2016

Pubmed Data : Nutr Cancer. 2016 Jul 1:1-11. Epub 2016 Jul 1. PMID: 27367621
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Modified Arabinoxylan Rice Bran (MGN-3)
Diseases : Ehrlich carcinoma
Pharmacological Actions : Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Mulberry water extract enhanced the cytotoxicity of paclitaxel and induced severe G2/M arrest, mitotic catastrophe and subsequent apoptosis.Dec 31, 2015

Pubmed Data : Sci Rep. 2016 ;6:20417. Epub 2016 Feb 3. PMID: 26838546
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Mulberry
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Plant Extracts
[+]

Nobiletin reversed paclitaxel resistance in multi-drug resistance tumors.Nov 25, 2019

Pubmed Data : Phytomedicine. 2019 Nov 26 ;67:153141. Epub 2019 Nov 26. PMID: 31884406
Article Published Date : Nov 25, 2019
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Cancers: Multi-Drug Resistant, Lung Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jul ;12(1):1506-14. Epub 2015 Mar 11. PMID: 25760096
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Silybin and paclitaxel in dextran-based nanoparticles are an effective treatment through chemotherapy sensitization and microenvironment modulation.Feb 06, 2020

Pubmed Data : J Control Release. 2020 Feb 7 ;321:198-210. Epub 2020 Feb 7. PMID: 32044390
Article Published Date : Feb 06, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Tumor Microenvironment
[+]

The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatmentJan 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Gene Ther. 2008 Feb ;15(2):101-7. Epub 2007 Dec 21. PMID: 18197164
Article Published Date : Jan 31, 2008
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cannabinoids , Cannabinoids: Synthetic
Diseases : Thyroid Cancer
Pharmacological Actions : Apoptotic, Cannabinoid Receptor Antagonist/Inverse Agonist, Chemosensitizer
Additional Keywords : Cannabinoid Receptors, Chemothapeutic Synergy: Paclitaxel
[+]

The synergistic anti cancer effects of paclitaxel and α-tomatine may be beneficial for refractory prostate cancer treatment.Nov 14, 2013

Pubmed Data : Phytomedicine. 2013 Nov 15 ;20(14):1297-305. Epub 2013 Aug 4. PMID: 23920276
Article Published Date : Nov 14, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tomato
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, PI3K-AKT inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Plant Extracts, Significant Treatment Outcome
[+]

These results showed that 20(s)-ginsenoside Rg3 enhanced the oral bioavailability of paclitaxel.Oct 31, 2012

Pubmed Data : Biopharm Drug Dispos. 2012 Nov ;33(8):425-36. Epub 2012 Sep 21. PMID: 22898996
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Wogonin combined with low-dose paclitaxel obtained the same efficacy as with high dose Paclitaxel reducing tumor burden by 61%.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin J Cancer Res. 2013 Oct ;25(5):505-13. PMID: 24255573
Article Published Date : Sep 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Natural Substance/Drug Synergy
[+]

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28249781
Article Published Date : Feb 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel
[+]

A combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells.Jun 24, 2015

Pubmed Data : J Recept Signal Transduct Res. 2015 Jun 25:1-8. Epub 2015 Jun 25. PMID: 26108226
Article Published Date : Jun 24, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Kidney Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Beta-elemene had synergistic effect with paclitaxel.Jun 30, 2013

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jul ;33(7):978-82. PMID: 24063225
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Co-delivery of paclitaxel and honokiol suppressed multidrug resistance and metastasis of breast cancer.Aug 27, 2017

Pubmed Data : Acta Biomater. 2017 Aug 28. Epub 2017 Aug 28. PMID: 28842335
Article Published Date : Aug 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Breast Cancer, Cancers: Multi-Drug Resistant
Pharmacological Actions : Anti-metastatic, Multidrug Resistance Gene Modulators
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0139298. Epub 2015 Sep 30. PMID: 26421434
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Colon Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Dose Response, Natural Substance/Drug Synergy
[+]

Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med. 2019 ;14:7. Epub 2019 Mar 12. PMID: 30911326
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Ovarian Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Combined treatment of β-elemene-paclitaxel is more effective at inhibiting bone neoplasm growth than β-elemene or paclitaxel single treatment GPR124.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Aug ;16(2):2143-2150. Epub 2018 Jun 6. PMID: 30008912
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Bone Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Combined ultrasonic treatment and chemotherapy with paclitaxel showed a significantly increased killing of MCF7 cells compared to both monotherapies.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015;10(8):e0134999. Epub 2015 Aug 4. PMID: 26241649
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Therapeutic Actions : Ultrasound therapy
Pharmacological Actions : Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Selective Cytotoxicity
[+]

Crocin and paclitaxel and crocin and gamma radiation had synergistic effect on MCF-7 cell line to get more significant apoptosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Breast Cancer. 2015 ;2015:139349. Epub 2015 Nov 26. PMID: 26693354
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Radiosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Cucurbitacin B, showed potential in vitro synergistic antiproliferative effects combined with paclitaxel in A549 cells.Jun 09, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2017 Jun 10 ;329:272-281. Epub 2017 Jun 10. PMID: 28610991
Article Published Date : Jun 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Curcumin by itself was as good as carboplatin or paclitaxel in inducing apoptosis in the primary ovarian cancer cells.Mar 31, 2016

Pubmed Data : J Cancer Res Ther. 2016 Apr-Jun;12(2):1050-5. PMID: 27461697
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Carboplatin, Natural Substances Versus Drugs
[+]

Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Apr ;9(4):1470-1476. Epub 2015 Jan 29. PMID: 25780454
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.Mar 31, 2017

Pubmed Data : Tumour Biol. 2017 Apr ;39(4):1010428317698353. PMID: 28443468
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Chemosensitizer
Additional Keywords : Carcinoma: Non-Small-Cell Lung, Chemosensitizer, Chemothapeutic Synergy: Paclitaxel, CURCUMIN
[+]

Curcumin sensitized breast cancer cells to chemotherapeutic drugs by reducing the BCSC population mainly through a reduction in the expression of ABCG2.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(8):e0136694. Epub 2015 Aug 25. PMID: 26305906
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Breast Cancer Stem Cells
Pharmacological Actions : Apoptotic, Chemopreventive, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Mitomycin C
[+]

Cytotoxicity of Tanshinone IIA combined with Taxol on drug-resist breast cancer cells MCF-7 through inhibition of Tau.Mar 31, 2018

Pubmed Data : Phytother Res. 2018 Apr ;32(4):667-671. Epub 2018 Jan 24. PMID: 29368408
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells.May 31, 2019

Pubmed Data : Br J Pharmacol. 2019 Jun ;176(12):2079-2094. Epub 2019 May 11. PMID: 30825187
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Diosmetin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Selective Cytotoxicity
[+]

Effect of Gallic acid in potentiating chemotherapeutic effect of paclitaxel in HeLa cervical cancer cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2019 ;19:154. Epub 2019 Jun 3. PMID: 31171918
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid
Diseases : Cervical Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Effect of ginseng rare ginsenoside components combined with paclitaxel on A549 lung cancer.Mar 31, 2018

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Apr ;43(7):1446-1452. PMID: 29728035
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Lung Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Fermented red ginseng extract may be more effective for decreasing cancer cell survival by inducing apoptotic cell death.Mar 31, 2015

Pubmed Data : J Med Food. 2015 Apr ;18(4):421-8. Epub 2015 Feb 6. PMID: 25658580
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Ginsenosides, Panax Ginseng
Diseases : Breast Cancer, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Folic acid significantly enhanced the efficacy of curcumin in down-regulating various survival signals induced by paclitaxel in cervical cancer.Dec 07, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Dec 8 ;8(64):107374-107389. Epub 2017 Nov 10. PMID: 29296172
Article Published Date : Dec 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Folic Acid
Diseases : Cervical Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Functional paclitaxel plus honokiol micelles destroying tumour metastasis in treatment of non-small-cell lung cancer.Jul 24, 2018

Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 Jul 25:1-16. Epub 2018 Jul 25. PMID: 30043652
Article Published Date : Jul 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Geraniol can constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2016 May ;48(5):1772-82. Epub 2016 Mar 9. PMID: 26983575
Article Published Date : Apr 30, 2016
Study Type : Review
Additional Links
Substances : Geraniol
Diseases : Breast Cancer, Cancers: All, Cancers: Drug Resistant, Colon Cancer, Kidney Cancer, Liver Cancer, Lung Cancer, Oral Cancer, Pancreatic Cancer, Prostate Cancer, Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin
[+]

Honokiol targets mitochondria to halt cancer progression and metastasis.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2016 Jun ;60(6):1383-95. Epub 2016 May 6. PMID: 27276215
Article Published Date : May 31, 2016
Study Type : Review
Additional Links
Substances : Honokiol
Diseases : Bone Cancer, Breast Cancer, Gastric Cancer, Glioblastoma, Kidney Cancer, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer, Radiosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine, Chemotherapeutic Synergy: Oxaliplatin, Natural Substance/Drug Synergy
[+]

Liposomal co-delivery of curcumin and albumin/paclitaxel nanoparticle for enhanced synergistic antitumor efficacy.Mar 31, 2015

Pubmed Data : Colloids Surf B Biointerfaces. 2015 Apr 1 ;128:419-426. Epub 2015 Mar 7. PMID: 25797481
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Liposomal codelivery of HSA-paclitaxel and HSA-ellagic acid complexes for enhanced drug perfusion and efficacy against pancreatic cancer.Aug 01, 2017

Pubmed Data : ACS Appl Mater Interfaces. 2017 Aug 2 ;9(30):25138-25151. Epub 2017 Jul 24. PMID: 28696100
Article Published Date : Aug 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Luteolin plays an important role in the treatment of human choriocarcinoma cells.Aug 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Reprod. 2016 Aug 31. Epub 2016 Aug 31. PMID: 27580988
Article Published Date : Aug 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Choriocarcinoma
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Natural Substance/Drug Synergy
[+]

MGN-3 is an effective chemosensitizer and may represent a novel adjuvant for the treatment of metastatic breast cancer.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2014 Jan ;34(1):81-7. PMID: 24403447
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Modified Arabinoxylan Rice Bran (MGN-3)
Diseases : Breast Cancer, Cancer Metastasis
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Modified citrus pectin targets galectin-3-induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Med. 2019 Aug ;8(9):4315-4329. Epub 2019 Jun 13. PMID: 31197964
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Ovarian Cancer
Pharmacological Actions : Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, STAT3 Inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer.Feb 20, 2018

Pubmed Data : Eur J Nutr. 2018 Feb 21. Epub 2018 Feb 21. PMID: 29468462
Article Published Date : Feb 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hydroxytyrosol
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Naringin acts as a chemosensitizer which synergistically strengthens the cytotoxic effect of paclitaxel in prostate cancer cells.Nov 30, 2018

Pubmed Data : Prostate Int. 2018 Dec ;6(4):126-135. Epub 2017 Nov 28. PMID: 30505814
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Prostate Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Nettle extract substantially increased sensitivity of breast cancer cells to paclitaxel.Aug 04, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug 5 ;83:835-842. Epub 2016 Aug 5. PMID: 27501501
Article Published Date : Aug 04, 2016
Study Type : In Vitro Study
Additional Links
Substances : Nettle
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Plant Extracts
[+]

Nobiletin significantly reversed ABCB1 mediated multidrug resistance in cancer cells. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:18789. Epub 2015 Dec 22. PMID: 26689156
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Cancers: All, Cancers: Multi-Drug Resistant, Colorectal Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Multidrug Resistance Gene Modulators
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Doxorubicin
[+]

Paclitaxel and curcumin coadministration in novel cationic PEGylated niosomal formulations exhibit enhanced synergistic antitumor efficacy.Mar 22, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nanobiotechnology. 2018 Mar 23 ;16(1):28. Epub 2018 Mar 23. PMID: 29571289
Article Published Date : Mar 22, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Selective Cytotoxicity
[+]

Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2015 Sep ;10(3):1649-1654. Epub 2015 Jun 25. PMID: 26622726
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Psychedelics:All
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Paclitaxel-betulinic acid hybrid nanosuspensions for enhanced anti-breast cancer activity.Jan 31, 2019

Pubmed Data : Colloids Surf B Biointerfaces. 2019 Feb 1 ;174:270-279. Epub 2018 Nov 14. PMID: 30469048
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Quercetin enhanced paclitaxel therapeutic effects towards PC-3 prostate cancer. Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2020 ;13:513-523. Epub 2020 Jan 16. PMID: 32021294
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Resveratrol enhances chemosensitivity of renal cell carcinoma to paclitaxel.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Biosci (Landmark Ed). 2019 Jun 1 ;24:1452-1461. Epub 2019 Jun 1. PMID: 31136990
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Shikonin can sensitize esophageal cancer cells to paclitaxel-treatment.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2019 Sep ;18(3):3195-3201. Epub 2019 Jul 25. PMID: 31452796
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Esophageal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells.Feb 26, 2017

Pubmed Data : Cancer Lett. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28254410
Article Published Date : Feb 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Docetaxel
[+]

Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines.Jul 31, 2018

Pubmed Data : Mol Med Rep. 2018 Aug ;18(2):1835-1841. Epub 2018 Jun 5. PMID: 29901126
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Gastric Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Tetramethylpyrazine enhances the antitumor effect of paclitaxel by inhibiting angiogenesis and inducing apoptosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:707. Epub 2019 Jun 25. PMID: 31293426
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ligustrazine
Diseases : Ovarian Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

The combination of fisetin and paclitaxel is expected to have a synergistic anticancer efficacy and a significant potential for the treatment of NSCLC.Feb 26, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Feb 27 ;19(3). Epub 2018 Feb 27. PMID: 29495431
Article Published Date : Feb 26, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Non-Small-Cell Lung Carcinoma
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Thermotherapy in combination with chemotherapy showed more strong inhibitory effect than those of thermotherapy or chemotherapy alone.Aug 31, 2008

Pubmed Data : Wei Sheng Yan Jiu. 2008 Sep ;37(5):529-32. PMID: 19069644
Article Published Date : Aug 31, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Lung Cancer
Therapeutic Actions : Heat Therapy
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Therapeutic Action Synergy with Drugs
[+]

Thymoquinone and paclitaxel combined act in synergy against triple negative breast cancer cells.Oct 25, 2015

Pubmed Data : Tumour Biol. 2015 Oct 26. Epub 2015 Oct 26. PMID: 26500095
Article Published Date : Oct 25, 2015
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, P21 Activation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Gene Expression Regulation
[+]

Thymoquinone enhances paclitaxel anti-breast cancer activity.Jan 19, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Jan 20 ;25(2). Epub 2020 Jan 20. PMID: 31968657
Article Published Date : Jan 19, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: Paclitaxel
[+]

Thymoquinone is a potentially effective suppressor of inflammation, tumor cell survival, proliferation, invasion, and angiogenesis.May 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cancer Res. 2008 Jun ;6(6):1059-70. PMID: 18567808
Article Published Date : May 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Acute Myeloid Leukemia, Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Doxorubicin
[+]

Ursolic acid reverses the chemoresistance of breast cancer cells to paclitaxel.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2019 ;9:501. Epub 2019 Jun 14. PMID: 31259152
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Chemosensitizer, MicroRNA modulator
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Vitamin D may further contribute to the cytotoxic effect of paclitaxel and carboplatin.Jan 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2017 12 ;37(12):6575-6581. PMID: 29187432
Article Published Date : Jan 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Endometrial Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Carboplatin
[+]

α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents.Jul 17, 2016

Pubmed Data : Int J Oncol. 2016 Jul 18. Epub 2016 Jul 18. PMID: 27431988
Article Published Date : Jul 17, 2016
Study Type : In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin
[+]

β-elemene and taxanes synergistically induce cytotoxicity and inhibit proliferation in ovarian cancer and other tumor cells.Feb 28, 2013

Pubmed Data : Anticancer Res. 2013 Mar ;33(3):929-40. PMID: 23482764
Article Published Date : Feb 28, 2013
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Docetaxel

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