Chemotherapeutic Synergy: Gemcitabine

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18 Diseases Researched for Chemotherapeutic Synergy: Gemcitabine
NameACCKFocus
Pancreatic Cancer4561Locked
Lung Cancer810Locked
Cancers: Drug Resistant68Locked
Breast Cancer44Locked
Colon Cancer24Locked
Cancers: Radiation-Resistant12Locked
Liver Cancer22Locked
Bladder Cancer11Locked
Bone Cancer11Locked
Breast Cancer: Triple Negative 11Locked
Cancers: All11Locked
Carcinoma: Non-Small-Cell Lung11Locked
Cervical Cancer11Locked
Cholangiocarcinoma11Locked
Gastric Cancer11Locked
Glioblastoma11Locked
Kidney Cancer11Locked
Prostate Cancer11Locked
50 Substances Researched for Chemotherapeutic Synergy: Gemcitabine
NameACCKFocus
Bromelain24Locked
Curcumin34Locked
EGCG (Epigallocatechin gallate)34Locked
Resveratrol24Locked
Cucurbitacin B 23Locked
Cysteine (see N-Acetylcysteine)13Locked
Ginsenosides23Locked
Indole-3-Carbinol23Locked
Piceatannol 23Locked
Piperlongumine 23Locked
Sulforaphane23Locked
Tocotrienol: Delta23Locked
Viruses: Beneficial23Locked
6-Shogaol12Locked
Astaxanthin12Locked
Betulinic acid22Locked
Capsaicin12Locked
Fisetin22Locked
Gold (nanoparticles)22Locked
Long Pepper12Locked
Oridonin12Locked
Orthosiphon12Locked
Polyphenols12Locked
Seaweed12Locked
Shikonin12Locked
Vitamin E12Locked
Adlay11Locked
Anthocyanins11Locked
Bee Venom11Locked
Berbamine11Locked
Bisdemethoxycurcumin11Locked
Chokeberry11Locked
Flavonoids11Locked
Genistein11Locked
Haplophyllum perforatum11Locked
Harmine11Locked
Honokiol11Locked
Isoflavones11Locked
Melatonin11Locked
Mistletoe11Locked
NAC (N-acetyl-L-cysteine)11Locked
Nexrutine (Phellodendrom)11Locked
Oat Bran11Locked
Omega-3 Fatty Acids11Locked
Phellinus Linteus11Locked
Pterostilbene11Locked
Quercetin11Locked
Thymoquinone11Locked
Triptolide11Locked
Vitamin C: Intravenous 11Locked
25 Pharmacological Actions Researched for Chemotherapeutic Synergy: Gemcitabine
NameACCKFocus
Chemosensitizer2938Locked
Antiproliferative 2535Locked
Apoptotic2432Locked
Chemotherapeutic1622Locked
NF-kappaB Inhibitor711Locked
Anti-metastatic68Locked
Cell cycle arrest46Locked
Antineoplastic Agents35Locked
Vascular Endothelial Growth Factor Inhibitors24Locked
Anti-Inflammatory Agents33Locked
Cyclin D1 Down-Regulation23Locked
Angiogenesis Inhibitors12Locked
Antioxidants12Locked
Autophagy Inhibitors12Locked
Bcl-2 protein down-regulation12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor12Locked
STAT3 Inhibitor22Locked
Survivin Down-Regulation12Locked
Autophagy Up-regulation11Locked
Bax/Bcl2 ratio: Increase11Locked
Cyclooxygenase 2 Inhibitors11Locked
Immunomodulatory11Locked
Interleukin-1 beta downregulation11Locked
P21 Activation11Locked
Radiosensitizer11Locked

View the Evidence:
58 Abstracts with Chemotherapeutic Synergy: Gemcitabine Research

[+]

A combination of cucurbitacin B and gemcitabine had profound anti-proliferative effects in vivo against pancreatic cancer cells.May 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2010 Jun ;160(4):998-1007. PMID: 20590594
Article Published Date : May 31, 2010
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin B
Diseases : Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2021 ;11(5):2252-2263. Epub 2021 May 15. PMID: 34094682
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain, Cysteine (see N-Acetylcysteine)
Diseases : Colon Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Sci. 2015 ;22(1):28. Epub 2015 Apr 17. PMID: 25898131
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Polyphenols, Seaweed
Diseases : Cancers: Drug Resistant, Cancers: Radiation-Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Autophagy Inhibitors, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Gene Expression Regulation, Significant Treatment Outcome
[+]

Astaxanthin inhibits gemcitabine-resistant human pancreatic cancer progressionOct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Nov ;14(5):5400-5408. Epub 2017 Aug 28. PMID: 29098031
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Chemovirotherapy of lung squamous cell carcinoma by combining oncolytic adenovirus with gemcitabine.Dec 31, 2019

Pubmed Data : Front Oncol. 2020 ;10:229. Epub 2020 Feb 25. PMID: 32158698
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Viruses: Beneficial
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Chemovirotherapy
[+]

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Pubmed Data : Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28089829
Article Published Date : Jan 11, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Capsaicin, Piceatannol , Resveratrol, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Natural Substance Synergy
[+]

Curcumin potentiates the activity of the chemotherapy agent gemcitabine in vitro and in vivo animal models of pancreatic cancer. Apr 15, 2007

Pubmed Data : Cancer Res. 2007 Apr 15;67(8):3853-61. PMID: 17440100
Article Published Date : Apr 15, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pancreatic Cancer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Drug-Plant-Vitamin Synergies
[+]

EGCG is a strong combination partner of gemcitabine reducing pancreatic cancer cell growth by suppressing glycolysis.Oct 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2019 Oct 5 ;11(10). Epub 2019 Oct 5. PMID: 31590367
Article Published Date : Oct 04, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Cancer Glycolysis, Chemotherapeutic Synergy: Gemcitabine
[+]

Indole-3-carbinol would be effective for enhancing sensitivity of pancreatic cancer cells to gemcitabine.Mar 31, 2013

Pubmed Data : Anticancer Res. 2013 Apr ;33(4):1473-81. PMID: 23564788
Article Published Date : Mar 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer.Jul 22, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2009 Jul 23 ;9:250. Epub 2009 Jul 23. PMID: 19624862
Article Published Date : Jul 22, 2009
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Lung Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Our study represents the first comprehensive preclinical evaluation of the activity of natural vitamin E compounds in pancreatic cancer.Nov 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cancer Ther. 2011 Dec ;10(12):2363-72. Epub 2011 Oct 4. PMID: 21971120
Article Published Date : Nov 30, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Pancreatic Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models.Feb 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Feb 13 ;9(12):10457-10469. Epub 2017 Dec 23. PMID: 29535819
Article Published Date : Feb 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model.Dec 13, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Dec 14. Epub 2015 Dec 14. PMID: 26667450
Article Published Date : Dec 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Long Pepper
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Pretreatment with 6-shogaol resulted in an inhibition of constitutive and gemcitabine induced NF-κB activity and exerted its chemosensitization effects to gemcitabine.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : AAPS J. 2014 Mar ;16(2):246-57. Epub 2014 Jan 15. PMID: 24424498
Article Published Date : Feb 28, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemotherapeutic, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Resveratrol, a multi-targeted agent, can enhance antitumor activity of gemcitabine in a mouse model of human pancreatic cancer.Nov 11, 2009

Pubmed Data : Int J Cancer. 2009 Nov 11. PMID: 19908231
Article Published Date : Nov 11, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Resveratrol
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Drug-Plant-Vitamin Synergies
[+]

The present results demonstrate that oridonin overcomes PANC-1/Gem cells gemcitabine reistance.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2019 ;12:5751-5765. Epub 2019 Jul 17. PMID: 31410021
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

These results suggest that the combination of SK and gemcitabine may be a promising chemotherapy regimen for pancreatic cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(12):5507-5517. Epub 2017 Dec 15. PMID: 29312502
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Toxicological studies of Orthosiphon stamineus standardized ethanol extract in combination with gemcitabine.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Adv Res. 2019 Jan ;15:59-68. Epub 2018 May 9. PMID: 30581613
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Orthosiphon
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Synergistic effects of piperlongumine and gemcitabine against KRAS mutant lung cancer.Jun 08, 2020

Pubmed Data : Tumori. 2020 Jun 9:300891620930789. Epub 2020 Jun 9. PMID: 32515291
Article Published Date : Jun 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Berbamine may be a promising candidate to be used in combination with gemcitabine for pancreatic cancer treatment.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anat Rec (Hoboken). 2014 May ;297(5):802-9. Epub 2014 Mar 12. PMID: 24619961
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berbamine
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signalingDec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2019 Jan ;54(1):98-110. Epub 2018 Oct 24. PMID: 30365057
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Cancer Stem Cells, Chemotherapeutic Synergy: Gemcitabine
[+]

Bisdemethoxycurcumin partially offsets the chemoresistance induced by gemcitabine and produces apoptosis in PANC-1 cells.Nov 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Nov 10. Epub 2016 Nov 10. PMID: 27845899
Article Published Date : Nov 09, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Chemovirotherapy of pancreatic adenocarcinoma by combining oncolytic vaccinia virus GLV-1h68 with nab-paclitaxel plus gemcitabine.Sep 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Ther Oncolytics. 2017 Sep 15 ;6:10-21. Epub 2017 Apr 19. PMID: 28607950
Article Published Date : Sep 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Viruses: Beneficial
Diseases : Pancreatic Cancer
Pharmacological Actions : Immunomodulatory
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Gemcitabine, Chemovirotherapy
[+]

Chokeberry extract in combination with gemcitabine was more effective than gemcitabine alone.Sep 16, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Pathol. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25232128
Article Published Date : Sep 16, 2014
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Chokeberry
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Natural Substance/Drug Synergy
[+]

Coix seed extract could augment the efficacy of gemcitabine therapy in pancreatic cancer cells.Oct 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 23 ;20(21). Epub 2019 Oct 23. PMID: 31652737
Article Published Date : Oct 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer.Jun 14, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Cancer. 2013 Jun 15 ;132(12):2730-7. Epub 2012 Dec 13. PMID: 23165325
Article Published Date : Jun 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Docetaxel, Chemotherapeutic Synergy: Gemcitabine
[+]

Curcumin inhibits pancreatic cancer cell growth and acts as a chemosensitizing agent. Jul 01, 2009

Pubmed Data : Mol Pharmacol. 2009 Jul;76(1):81-90. Epub 2009 Apr 24. PMID: 19395473
Article Published Date : Jul 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Drug: Gemcitabine
[+]

Curcumin significantly increased the effectiveness of gemcitabine treatment in vitro via the CUGBP2-mediated post-transcriptional regulation pathway.Dec 20, 2015

Pubmed Data : Langenbecks Arch Surg. 2015 Dec 21. Epub 2015 Dec 21. PMID: 26691217
Article Published Date : Dec 20, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
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DIM and isoflavone may lead to the reversal of a gemcitabine-resistant pancreatic cancer phenotype. Aug 15, 2009

Pubmed Data : Cancer Res. 2009 Aug 15;69(16):6704-12. Epub 2009 Aug 4. PMID: 19654291
Article Published Date : Aug 15, 2009
Study Type : In Vitro Study
Additional Links
Substances : Isoflavones
Diseases : Pancreatic Cancer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Epigenetic Modification
[+]

EGCG may prove beneficial to improve gemcitabine sensitivity in inhibiting pancreatic cancer cell migration and invasion.Aug 08, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Aug 9 ;11(8). Epub 2019 Aug 9. PMID: 31405071
Article Published Date : Aug 08, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines.Jan 14, 2020

Pubmed Data : Arch Biochem Biophys. 2020 10 15 ;692:108546. Epub 2020 Aug 18. PMID: 32818507
Article Published Date : Jan 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Colon Cancer, Lung Cancer, Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine
[+]

Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines.Sep 30, 2011

Pubmed Data : Anticancer Res. 2011 Oct ;31(10):3171-80. PMID: 21965724
Article Published Date : Sep 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2020 ;12(11):7404-7419. Epub 2020 Nov 15. PMID: 33312377
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Liver Cancer, Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine
[+]

Fisetin sensitized human pancreatic cancer cells to gemcitabine-induced cytotoxicityMay 31, 2018

Pubmed Data : Anticancer Res. 2018 Jun ;38(6):3527-3533. PMID: 29848706
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Gemcitabine and betulinic acid co-encapsulated PLGA-PEG polymer nanoparticles for improved efficacy of cancer chemotherapy.Apr 30, 2019

Pubmed Data : Mater Sci Eng C Mater Biol Appl. 2019 May ;98:764-771. Epub 2019 Jan 8. PMID: 30813082
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Genistein potentiates the chemotherapeutic activity of erlotinib and gemcitabine in the treatment of pancreatic cancer cell lines. May 01, 1999

Pubmed Data : Epidemiology. 1999 May;10(3):337-9. PMID: 17079479
Article Published Date : May 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Pancreatic Cancer
Additional Keywords : Chemotherapeutic Synergy: Erlotinib, Chemotherapeutic Synergy: Gemcitabine, Drug-Plant-Vitamin Synergies
[+]

Ginsenoside Rg3 inhibits gemcitabine-induced lung cancer cell invasiveness.Jan 08, 2019

Pubmed Data : J Cell Physiol. 2019 Jan 9. Epub 2019 Jan 9. PMID: 30628067
Article Published Date : Jan 08, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Anti-metastatic, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Gold Nanoparticles sensitize pancreatic cancer cells to gemcitabine.Jul 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Stress. 2019 Jul 31 ;3(8):267-279. Epub 2019 Jul 31. PMID: 31440741
Article Published Date : Jul 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gold (nanoparticles)
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Gold nanoparticles-gemcitabine conjugate is more effective and safe at dosages 275-fold lower than the current clinically-used systemic dose of gemcitabine.Jul 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nanomedicine. 2014 Aug ;10(6):1121-30. Epub 2014 Mar 17. PMID: 24650884
Article Published Date : Jul 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Gold (nanoparticles)
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Haplamine extracted from Haplophyllum perforatum provesto be significantly more potent in pancreatic cells than gemcitabine, the reference cytotoxic drug for treating pancreatic carcinomas.Aug 01, 2008

Pubmed Data : Planta Med. 2008 Aug;74(10):1265-8. Epub 2008 Jul 29. PMID: 18666046
Article Published Date : Aug 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Haplophyllum perforatum
Diseases : Pancreatic Cancer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Superiority of Natural Substances versus Drugs
[+]

Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2019 ;12:4585-4593. Epub 2019 Jun 12. PMID: 31354292
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Hispidin might be a novel chemosensitizer for gemcitabine.Jun 30, 2018

Pubmed Data : Anticancer Res. 2018 Jul ;38(7):3967-3975. PMID: 29970519
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Cancer Stem Cells, Chemotherapeutic Synergy: Gemcitabine
[+]

Honokiol targets mitochondria to halt cancer progression and metastasis.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2016 Jun ;60(6):1383-95. Epub 2016 May 6. PMID: 27276215
Article Published Date : May 31, 2016
Study Type : Review
Additional Links
Substances : Honokiol
Diseases : Bone Cancer, Breast Cancer, Gastric Cancer, Glioblastoma, Kidney Cancer, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer, Radiosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine, Chemotherapeutic Synergy: Oxaliplatin, Natural Substance/Drug Synergy
[+]

Inhibitory effect of oat bran ethanol extract on survival and gemcitabine resistance of pancreatic cancer cells.Oct 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Oct 24 ;24(21). Epub 2019 Oct 24. PMID: 31652886
Article Published Date : Oct 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oat Bran
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Plant Extracts
[+]

Melatonin inhibits proliferation and invasion of PDAC cells and overcomes gemcitabine resistance of pancreatic tumors through NF-κB inhibition.Oct 06, 2015

Pubmed Data : J Pineal Res. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26445000
Article Published Date : Oct 06, 2015
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Drug Resistant Cancer, Gemcitabine Resistance
[+]

Melittin is capable of suppressing tumor growth and promoting gemcitabine sensitivity in pancreatic ductal adenocarcinoma.Jul 27, 2017

Pubmed Data : Cancer Lett. 2017 Jul 28 ;399:1-9. Epub 2017 Apr 17. PMID: 28428074
Article Published Date : Jul 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bee Venom
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Nexrutine has the potential to improve gemcitabine sensitivity.Jan 31, 2017

Pubmed Data : Mol Carcinog. 2017 Feb ;56(2):402-411. Epub 2016 May 25. PMID: 27208550
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Nexrutine (Phellodendrom)
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemosensitizer, NF-kappaB Inhibitor, STAT3 Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Omega 3 fatty acids inhibit proliferation of various chemoresistant (gemcitabine resistant) pancreatic cancer cell lines. Dec 01, 2007

Pubmed Data : Ann Surg Oncol. 2007 Dec;14(12):3620-8. Epub 2007 Sep 26. PMID: 17896154
Article Published Date : Dec 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Pancreatic Cancer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Gemcitabine Resistance, Superiority of Natural Substances versus Drugs
[+]

Pharmacologic ascorbate also inhibits the growth of pancreatic tumor xenografts and displays synergistic cytotoxic effects when combined with gemcitabine in pancreatic cancer. Dec 31, 2014

Pubmed Data : Curr Pharm Biotechnol. 2015 ;16(9):759-70. PMID: 26201606
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Vitamin C: Intravenous
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Selective Cytotoxicity
[+]

Piceatannol can enhance the cytotoxic effects of gemcitabine.Dec 31, 2013

Pubmed Data : Oncol Res. 2014 ;22(4):213-7. PMID: 26351210
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Pterostilbene enhances cytotoxicity and chemosensitivity in human pancreatic cancer cells.May 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 May 4 ;10(5). Epub 2020 May 4. PMID: 32375296
Article Published Date : May 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Quercetin facilitates cell death and chemosensitivity in human pancreatic cancer cells.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2019 Oct ;27(4):887-896. Epub 2019 Aug 21. PMID: 31590760
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Sulforaphane exhibits anti-carcinogenic activity against cervical cancer. Oct 16, 2010

Pubmed Data : Cancer Epidemiol. 2010 Oct 16. Epub 2010 Oct 16. PMID: 20956097
Article Published Date : Oct 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cervical Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Drug: Gemcitabine, Drug-Plant-Vitamin Synergies
[+]

These in vitro results are in line with clinical experiences and trials that Iscador can be used concomitant with conventional oncological drugs without safety hazard by herb drug interactions.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14:6. Epub 2014 Jan 8. PMID: 24397864
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Mistletoe
Diseases : Breast Cancer, Lung Cancer, Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine
[+]

These results suggest fisetin in combination with gemcitabine as a candidate for use in improved anticancer regimens.Jan 10, 2016

Pubmed Data : Anticancer Res. 2016 11 ;36(11):6109-6116. PMID: 27793939
Article Published Date : Jan 10, 2016
Study Type : In Vitro Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Antiproliferative, Apoptotic, Chemotherapeutic, Chemotherapeutic Synergy: Gemcitabine, Cholangiocarcinoma, Fisetin, Flavonoids
[+]

This study demonstrated for the first time that δ-T3 is a potent agent against human bladder cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0122712. Epub 2015 Apr 7. PMID: 25849286
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemosensitizer, STAT3 Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities.Aug 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Aug 3 ;8(1):11674. Epub 2018 Aug 3. PMID: 30076320
Article Published Date : Aug 02, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(6):3750-3760. Epub 2019 Jun 15. PMID: 31312385
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Triptolide
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

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