Epigenetic Modification

Name	AC	CK
Bisphenol A	7	18
Aromatic hydrocarbons	1	10
Infant Formula	1	10
Soy	1	10
Endocrine Disruptors	3	3
Chlorpyrifos	1	2
Electronic Cigarettes	1	2
Etoposide	1	2
Vinclozolin	1	2
Aluminum	1	1
Mercury	1	1
Pesticides	1	1
Pitocin (Synthetic Oxytocin)	1	1

Name	AC	CK
Prenatal Chemical Exposures	5	36
Fetal Origin of Adult Disease	4	24
Smoking	2	22
Asthma	1	20
Cancers: All	19	20
Breast Cancer	7	16
Bisphenol Toxicity	3	14
Aging	3	12
Cesarean Section	2	11
Oral Cancer	2	11
Celiac Disease: Prevalance	1	10
Celiac Disease: Prevention	1	10
Diabetes Mellitus: Type 2: Prevention	1	10
Female Reproductive Development Abnormalities	1	10
Inflammation	8	10
Polycystic Ovary Syndrome	1	10
Sleep Disorders	1	10
Cardiovascular Diseases	4	6
DNA damage	4	6
Cervical Cancer	1	5
Neurodegenerative Diseases	5	5
Oxidative Stress	4	5
Prostate Cancer	5	5
Alzheimer's Disease	3	4
Colon Cancer	3	4
Folic Acid/Folate Deficiency	2	4
Autoimmune Diseases	2	3
Diabetes: Cardiovascular Illness	2	3
Alcohol Toxicity	2	2
Breast Cancer: Chemically-Induced	1	2
Cardiomyopathy	1	2
Cardiomyopathy: Hypertrophic	1	2
Colitis	1	2
Cystic Fibrosis	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes Mellitus: Type 2	2	2
Diabetes: Kidney Function	1	2
Diabetic Nephropathy	1	2
Dry Mouth	1	2
Endocrine Imbalances	2	2
Epilepsy	1	2
Fatty Liver	1	2
Graves Disease	1	2
Gulf War Syndrome	1	2
Hyperlipidemia	1	2
Hypertension	1	2
Hyperthyroidism	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Kidney Diseases	1	2
Leukemia	1	2
Melanoma: Metastatic	2	2
Memory Disorders	1	2
Morphine Tolerance/Dependence	1	2
Pesticide Toxicity	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Salivary Gland Diseases	1	2
Sexual Development: Dysfunctions and Abnormalities	1	2
Stroke: Ischemic	1	2
Vitamin B 12 Deficiency	1	2
Vitamin B Deficiency	1	2
Zinc Deficiency	1	2
Abnormalities	1	1
Aging: Brain	1	1
Aluminum Toxicity	1	1
Amyotrophic Lateral Sclerosis	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bipolar Disorder	1	1
Birth: Labor & Delivery	1	1
Bladder Cancer	1	1
Bone Diseases	1	1
Bone Fractures	1	1
Brain Inflammation	1	1
Brain: Microglial Activation	1	1
Breast Cancer: BRCA1	1	1
Breast Cancer: Metastatic	1	1
Breast Cancer: Triple Negative	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cardiovascular Disease: Prevention	1	1
Circadian Dysregulation	1	1
Colon Cancer: Prevention	1	1
Colorectal Cancer	1	1
Depression	1	1
Diabetes Mellitus: Type 1: Prevention	1	1
Drug-Induced	1	1
Epstein-Barr Virus Infections	1	1
Gastric Cancer	1	1
Glioma	1	1
HIV Infections	1	1
Infertility	1	1
Infertility: Female	1	1
Insulin Resistance	1	1
Lipid Peroxidation	1	1
Lung Cancer	1	1
Melanoma	1	1
Metabolic Diseases	1	1
Neuroblastoma	1	1
Neutropenia: Severe Congenital	1	1
Osteoporosis	1	1
Oxytocin: Low Levels	1	1
Pancreatic Cancer	1	1
Parkinson's Disease	1	1
Psychiatric Disorders	1	1
Schizophrenia	1	1
Skin Cancer	1	1
Stress	1	1
Stroke	1	1
Stroke: Attenuation/Recovery	1	1
Testicular Cancer	1	1
Vitamin D Deficiency	1	1

Name	AC	CK
Cesarean Delivery	3	21
Prenatal Stress	2	3
Artifical Lighting	2	2
Mobile Phone Radiation	1	2

Name	AC	CK	Focus
Immunotoxic	1	10
Endocrine Disruptor	1	2

Name	AC	CK
Polyphenols	10	21
Curcumin	12	16
Black Raspberry	2	15
Flavonoids	3	13
Vitamin C	12	12
Breast Milk	1	10
Vitamin B-12	1	10
Sulforaphane	7	8
EGCG (Epigallocatechin gallate)	6	6
Resveratrol	4	6
Amla Fruit	1	5
Folic Acid	3	4
Genistein	4	4
Isoflavones	3	4
Apples	2	3
Melatonin	3	3
Catechin	2	2
Delta-tetrahydrocannabinol (THC)	1	2
Folate	1	2
Ginseng (American)	1	2
Indole-3-Carbinol	2	2
Saccharomyces Boulardii	1	2
Soy	1	2
Tetrahydrocurcumin	1	2
Wogonin	1	2
Anthocyanins	1	1
Black Tea	1	1
Blueberry	1	1
Broccoli	1	1
Chaparral	1	1
Cruciferous Vegetables	1	1
Epicatechin	1	1
Garlic	1	1
Glutathione	1	1
Green Tea	1	1
Isothiocyanates	1	1
Luteolin	1	1
Phospholipids	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Quercetin	1	1
S-Adenosylmethionine (SAMe)	1	1
Silibinin	1	1
Spirulina	1	1
Stilbenes	1	1
Thyme	1	1
Vitamin A	1	1
Vitamin B12: methylcobalamin	1	1
Vitamin B6	1	1
Vitamin D	1	1

Name	AC	CK
Breastfeeding	1	10
Electroacupuncture	1	10
Exercise	1	10
Exercise: Endurance	1	10
Meditation	1	10
Dietary Modification: Low Carbohydrate/Ketogenic	2	3
Dietary Modification: Mediterranean Diet	1	2
Acupuncture	1	1
Dietary Modification: Low Calorie Diet	1	1
Reiki Therapy	1	1

Name	AC	CK
MicroRNA modulator	9	28
Chemopreventive	11	25
Antiproliferative	6	14
Apoptotic	9	14
Histone deacetylase inhibitor	12	12
Anticarcinogenic Agents	6	11
Antioxidants	8	11
Gene Protective	2	11
Anti Inflammatory	1	10
Antineoplastic Agents	4	8
Anti-metastatic	3	7
Neuroprotective Agents	5	7
Antiviral Agents	2	6
Anti-Angiogenic	1	5
Anti-Tumor	1	5
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	5
Vascular Endothelial Growth Factor Inhibitors	1	5
anti-inflammatory	1	5
Anti-Inflammatory Agents	4	4
Hepatoprotective	2	4
Immunomodulatory	3	4
NF-kappaB Inhibitor	3	4
Telomerase Inhibitor	3	3
Anticonvulsants	1	2
Cell cycle arrest	2	2
DNA Repair Up-regulation	1	2
Hypolipidemic	1	2
Hypotensive	1	2
Interleukin-6 Downregulation	1	2
Nrf2 activation	2	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vasodilator Agents	1	2
Angiogenesis Inhibitors	1	1
Antimutagenic Agents	1	1
Cardioprotective	1	1
Caspase-9 Activation	1	1
Chemotherapeutic	1	1
Enzyme Inhibitors	1	1
Estrogen Receptor Modulators	1	1
Glutathione Upregulation	1	1
Receptor activator of NF-κB (RANK) gene expression	1	1
Regenerative	1	1

Additional Keywords : Epigenetic Modification

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B12 supplementation influences regulation of several metabolically important Type 2 diabetes-associated genes through methylation of miR21.Nov 13, 2017

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Pubmed Data : Epigenomics. 2017 Nov 14. Epub 2017 Nov 14. PMID: 29135286

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Pubmed Data : Acta Paediatr. 2009 Jul ;98(7):1096-9. PMID: 19638013

Article Published Date : Jun 30, 2009

Study Type : Human Study

Additional Links

Diseases : Cesarean Section

Additional Keywords : DNA Methylation, Epigenetic Modification

Anti Therapeutic Actions : Cesarean Delivery

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Girls fed soy formula had altered DNA methylation in vaginal cell DNA which may be associated with decreased expression of an estrogen-responsive gene.Dec 31, 2016

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Pubmed Data : Brain Behav Immun. 2020 Feb ;84:36-44. Epub 2019 Nov 13. PMID: 31733290

Pubmed Data : Physiol Behav. 2020 Aug 14 ;227:113135. Epub 2020 Aug 14. PMID: 32798568

Article Published Date : Aug 13, 2020

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Pubmed Data : Biomed Environ Sci. 2015 Aug ;28(8):558-70. PMID: 26383594

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2018 ;9:1832. Epub 2018 Aug 14. PMID: 30154787

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Pubmed Data : Science. 2017 04 21 ;356(6335):320-323. PMID: 28428426

Article Published Date : Jan 21, 2017

Study Type : Animal Study

Additional Links

Additional Keywords : Epigenetic Modification

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Pubmed Data : Neuropharmacology. 2015 Aug 6 ;99:500-509. Epub 2015 Aug 6. PMID: 26256422

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Pubmed Data : Biol Open. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26092868

Article Published Date : Jun 18, 2015

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Cystic Fibrosis, Dry Mouth, Salivary Gland Diseases

Additional Keywords : Epigenetic Modification

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S. boulardii reduces colonic inflammation in a rat experimental model of Colitis.Jul 10, 2008

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Pubmed Data : Dig Dis Sci. 2008 Jul 10. PMID: 18612822

Pubmed Data : Food Chem Toxicol. 2013 Sep ;59:724-30. Epub 2013 Jul 17. PMID: 23872129

Article Published Date : Aug 31, 2013

Study Type : Animal Study

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Pubmed Data : Int J Oncol. 2012 Jul ;41(1):353-61. Epub 2012 Apr 26. PMID: 22552582

Article Published Date : Jun 30, 2012

Study Type : In Vitro Study

Additional Links

Substances : Catechin , Polyphenols

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic, Histone deacetylase inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Epigenetic Modification, Plant Extracts

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"Humanity and human DNA."Sep 30, 2012

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Pubmed Data : AAPS J. 2011 Dec ;13(4):606-14. Epub 2011 Sep 22. PMID: 21938566

Article Published Date : Dec 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Prostate Cancer

Additional Keywords : Epigenetic Modification

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Curcumin supplementation by reducing vascular inflammation may prevent diabetic complications.Jul 21, 2010

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Pubmed Data : J Nutr Biochem. 2010 Jul 21. Epub 2010 Jul 21. PMID: 20655188

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Pubmed Data : Anticancer Drugs. 2008 Jun;19(5):487-94. PMID: 18418215

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Chaparral

Diseases : Breast Cancer

Additional Keywords : Epigenetic Modification

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Neuroprotective effects of Paeonia Lactiflora extract against cell death of dopaminergic SH-SY5Y cells is mediated by epigenetic modulation.Jul 11, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Jul 12 ;16:208. Epub 2016 Jul 12. PMID: 27405852

Article Published Date : Jul 11, 2016

Study Type : In Vitro Study

Additional Links

Substances : Peony

Diseases : Brain: Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

Additional Keywords : Epigenetic Modification, Plant Extracts

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Prenatal exposures to endocrine disruptors, heavy metals, and other environmental contaminants can result in fetal epigenomic changes.Jan 01, 2017

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Pubmed Data : Epigenomics. 2017 03 ;9(3):333-350. Epub 2017 Feb 17. PMID: 28234024

Article Published Date : Jan 01, 2017

Study Type : Review

Additional Links

Diseases : Fetal Diseases

Additional Keywords : Epigenetic Modification, Pregnancy

Anti Therapeutic Actions : Vaccination: All

Problem Substances : Heavy Metals, Xenobiotics

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Prenatal stress could, through the generation of epigenetic alterations, become one of the most powerful influences on mental health in later life.Dec 31, 2014

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Pubmed Data : Neurosci Biobehav Rev. 2015 Jan ;48:70-91. Epub 2014 Nov 24. PMID: 25464029

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Fetal Origin of Adult Disease, Psychiatric Disorders, Stress

Additional Keywords : Epigenetic Modification, Transgenerational Epigenetic Modification

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Quercetin, epigallocatechin gallate, curcumin, and resveratrol: from dietary sources to human microRNA modulation.Dec 22, 2019

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Pubmed Data : Trends Genet. 2020 Jan 14. Epub 2020 Jan 14. PMID: 31952840

Article Published Date : Jan 13, 2020

Study Type : In Vitro Study

Additional Links

Additional Keywords : Epigenetic Modification, Transgenerational inheritance

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Sulforaphane and epigallocatechin-3-gallate (EGCG) can positively modulate the epigenome and lead to many health benefits.Dec 31, 2014

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Pubmed Data : Curr Pharmacol Rep. 2015 Nov 1 ;1(6):382-390. Epub 2015 Apr 16. PMID: 26557472

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Pubmed Data : Am J Physiol Cell Physiol. 2016 Jul 1 ;311(1):C129-35. Epub 2016 Apr 27. PMID: 27122159

Article Published Date : Jun 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Alcohol Toxicity

Additional Keywords : Epigenetic Modification

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These findings together indicate an epigenetic role of vitamin C in midbrain DA neuron development.Mar 31, 2015

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Pubmed Data : Stem Cells. 2015 Apr ;33(4):1320-32. PMID: 25535150

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Pubmed Data : Oncotarget. 2015 Jul 10 ;6(19):16866-82. PMID: 26220712

Article Published Date : Jul 09, 2015

Study Type : Review

Additional Links

Substances : Melatonin

Diseases : Breast Cancer, Circadian Dysregulation

Additional Keywords : Circadian Clock Proteins, Epigenetic Modification

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This review focuses on encompassing the efficacy and mechanisms of silibinin against lung cancer.Dec 31, 2012

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Pubmed Data : Nutr Cancer. 2013 ;65 Suppl 1:3-11. PMID: 23682778

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Pubmed Data : Epigenomics. 2017 Jun ;9(6):863-871. Epub 2017 May 30. PMID: 28554227

Article Published Date : May 31, 2017

Study Type : Review

Additional Links

Substances : Vitamin A, Vitamin C

Diseases : Cancers: All

Pharmacological Actions : Regenerative

Additional Keywords : Cancers: All, Epigenetic Modification, Regenerative, Vitamin A, Vitamin C

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Vitamin C augmented pluripotency in iPS cells and reduced unwanted spontaneous differentiation during iPS cells maintenance.Jun 24, 2016

Pubmed Data : Clin Epigenetics. 2015 ;7(1):51. Epub 2015 Apr 29. PMID: 25977731

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Melanoma: Metastatic, Skin Cancer

Pharmacological Actions : Anti-metastatic

Additional Keywords : Epigenetic Modification

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When Vitamin D is deficient, many processes begin to decline and this sets the stage for the onset of diseases such as diabetes.Mar 23, 2017

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Pubmed Data : Biochem J. 2017 Mar 24 ;474(8):1321-1332. Epub 2017 Mar 24. PMID: 28341729

Article Published Date : Mar 23, 2017

Study Type : Review

Additional Links

Substances : Vitamin D

Diseases : Diabetes Mellitus: Type 1: Prevention, Diabetes Mellitus: Type 2, Insulin Resistance, Oxidative Stress, Vitamin D Deficiency

Additional Keywords : Epigenetic Modification

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View the Evidence: 159 Abstracts with Epigenetic Modification Research

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This meta-analysis strongly suggested a significant association of the MTHFR C677T polymorphism with autism.Jan 01, 2016

This study found substantial persistence of the effects of maternal smoking identified in newborns into later childhood.Apr 06, 2016

A single bout of electroacupuncture remodels epigenetic and transcriptional changes in adipose tissue in polycystic ovary syndrome.Jan 29, 2018

B12 supplementation influences regulation of several metabolically important Type 2 diabetes-associated genes through methylation of miR21.Nov 13, 2017

Breast-feeding protects against celiac disease. May 01, 2002

Celiac disease prevalence is higher in females, but suprisingly more common in HLA-DQ2/8 negative males, suggesting a sex bias and possible parent-specific epigenetic modifications in the two genders.Apr 01, 2008

Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells.Dec 31, 2014

Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress.Dec 31, 2011

Endurance training positively affects thousands of DNA methylation sites and genes which leads to improvement in muscle function and health.Dec 01, 2014

Epigenetic modulation at birth - altered DNA-methylation in white blood cells after Caesarean section.Jun 30, 2009

Girls fed soy formula had altered DNA methylation in vaginal cell DNA which may be associated with decreased expression of an estrogen-responsive gene.Dec 31, 2016

Physical exercise improves breast cancer survival and is likely mediated through epigenetic modification of breast tunmors.Aug 12, 2011

Prenatal bisphenol A exposure is linked to epigenetic changes in glutamate receptor subunit gene grin2b in female rats and humans.Jul 26, 2018

Short meditation intervention in trained subjects may rapidly influence the epigenome at sites of potential relevance for immune function.Jan 31, 2020

Short-term sleep deprivation leads to decreased systemic redox metabolites and altered epigenetic status.Dec 31, 2016

Synesthesia in twins: incomplete concordance in monozygotes suggests extragenic factors.May 31, 2015

The aquatic exercise program induced functional improvement in individuals with Parkinson's disease.Aug 13, 2020

The mode of delivery could affect the epigenetic state of newborn infants.Oct 31, 2014

This hypothesizes that the cumulative effects of a regular meditation practice may help to slow the epigenetic clock.Oct 31, 2017

This pilot study provides the first evidence of miRNA modulation by diet and other factors, that can be detected consistently in both plasma and stools samples.Aug 31, 2014

A Black Raspberry extract could prevent the initiation, promotion, and progression of carcinogenesis in the digestive tract and esophagus.Oct 27, 2014

An extract of Amla fruit inhibited human papillomavirus viral oncogenes responsible for development and progression of cervical cancer.Dec 31, 2012

Long-term, low-level microwave exposure may inhibit learning and memory by altering gene expression.Aug 01, 2015

Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications.Sep 23, 2019

"Epigenetic instability in ES cells and cloned mice."Jul 05, 2001

A high methionine, low folate and vitamin B6/B12 containing diet can be associated with memory loss.Jun 30, 2019

American Ginseng positively effects the phenotype expression of genes associated with diabetes in the male rat.Oct 17, 2007

Apples may exert their colon cancer protective effects through favorably altering gene patterns resulting in protection of cells against toxicological insults. Jun 15, 2008

Bacosides encapsulated in lactoferrin conjugated PEG-PLA-PCL-OH based polymersomes act as epigenetic modulator in chemically induced amnesia.Mar 31, 2020

Butyrate and dietary soluble fiber improves neuroinflammation associated with aging.Dec 31, 2017

Chlorpyrifos may act as a breast cancer risk factor.Oct 01, 2018

Curcumin blocks chronic morphine analgesic tolerance and positively modulates brain chemistry. Jan 07, 2009

Curcumin may play a role in preventing diabetes-induced cardiomyopathy. Jun 01, 2008

Curcumin protects against the development of diabetic nephropathy, in a diabetic rat experimental model. Mar 01, 2008

Delta-tetrahydrocannabinol (THC) may modulate immune response through epigenetic regulation involving histone modifications.Jul 03, 2014