Gene Expression Regulation

Name	AC	CK
Doxorubicin	1	5
Acetaminophen	1	2
Pesticides	1	2
Meat: Cooked	1	1
Polycyclic aromatic hydrocarbon	1	1

Name	AC	CK
Breast Cancer	18	36
Lung Cancer	14	36
Oxidative Stress	12	34
Inflammation	10	24
Prostate Cancer	13	21
Colon Cancer	11	19
Obesity	11	19
Carcinoma: Non-Small-Cell Lung	6	18
High Fat Diet	8	16
Cancers: Drug Resistant	6	15
Cancers: All	8	14
Oral Cancer	2	11
Anemia: Sickle Cell	1	10
Asthma	1	10
Breast Cancer: BRCA1	1	10
Breast Cancer: Drug Resistant	2	10
Carcinoma: Small Cell Lung	1	10
Fibrosarcoma	1	10
Glioblastoma Multiforme	1	10
Leukemia: Monocytic	1	10
Lung Cancer: Metastatic	1	10
Sitting Sickness	1	10
Alzheimer's Disease	6	9
Breast Cancer: Triple Negative	9	9
Colorectal Cancer	7	9
Hypercholesterolemia	4	8
DNA damage	3	7
Diabetes Mellitus: Type 2	4	7
Insulin Resistance	4	7
Atherosclerosis	3	6
Cancer Metastasis	3	6
Cognitive Decline/Dysfunction	3	6
Memory Loss	3	6
Metabolic Diseases	3	6
Astrocytoma	1	5
Breast Cancer: Metastatic	3	5
Cervical Cancer	5	5
Colon Cancer: Prevention	3	5
Glioblastoma	1	5
Graves Disease	1	5
Hydrogen Peroxide Induced Toxicity	1	5
Leukemia: Chronic myelogenous leukemia (CML)	1	5
Non-Small-Cell Lung Carcinoma	1	5
Nonalcoholic fatty liver disease (NAFLD)	3	5
Osteoarthritis	3	5
Wound Healing	1	5
Bladder Cancer	3	4
Cachexia	2	4
Diabetes Mellitus: Type 1	2	4
Down Syndrome	2	4
Hyperlipidemia	2	4
Liver Cancer	3	4
Multiple Sclerosis	2	4
Pancreatic Cancer	3	4
Triglycerides: Elevated	2	4
Breast Cancer: Chemically-Induced	2	3
Breast Cancer: Lung Metastasis	2	3
Dementia	2	3
Leukemia	2	3
Lipid Peroxidation	2	3
Osteoporosis	2	3
Ovarian Cancer	3	3
Prostate Cancer: Prevention	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Acute Myeloid Leukemia	2	2
Acute Respiratory Distress Syndrome	1	2
Aging	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Amnesia	1	2
Autoimmune Diseases	1	2
Brain Edema	1	2
Brain Hypoxia	1	2
Cachexia: Cancer	1	2
Cachexia: Chemotherapy Induced	1	2
Cancers: Radiation-Resistant	1	2
Chemically-Induced Liver Damage	1	2
Chronic Kidney Disease (CKD)	1	2
Clostridium Infections	1	2
Demyelinating Diseases	1	2
Diabetes Mellitus: Type 2: Prevention	1	2
Diabetic Nephropathy	1	2
Dysbiosis: Bifidobacteria Deficiency	1	2
Encephalomyelitis	1	2
Epilepsy	1	2
Heart Failure	1	2
Hepatic Steatosis	1	2
Hepatitis C	1	2
Inflammatory Bowel Diseases	1	2
Intracerebral Hemorrhage	1	2
Kidney Fibrosis	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Steatosis	1	2
Lung Injury: Acute	1	2
Memory Disorders	1	2
Muscle Atrophy	1	2
Nicotine/Tobacco Toxicity	1	2
Periodontitis	1	2
Prediabetes	1	2
Pseudomonas aeruginosa	2	2
Pulmonary Emphysema	1	2
Pulmonary Fibrosis	1	2
Rheumatoid Arthritis	1	2
Seizures	1	2
Snake Bite: Venom Toxicity	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stress	1	2
Stroke: Attenuation/Recovery	1	2
Systemic Lupus Erythematosus	1	2
Ultraviolet Radiation Induced Damage	1	2
Vitamin D Deficiency	1	2
Werner Syndrome	1	2
AIDS	1	1
Advanced Glycation End products (AGE)	1	1
Avian Influenza	1	1
Bile Duct Cancer	1	1
Bone Diseases	1	1
Bone Fractures	1	1
Brain Cancer	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Candidiasis: Vulvovaginal	1	1
Cardiovascular Diseases	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cholangiocarcinoma	1	1
Chronic Myeloid Leukemia	1	1
Cytomegalovirus Infections	1	1
Endometrial Cancer	1	1
Esophageal Cancer	1	1
Fibrosis	1	1
Gastric Cancer	1	1
Gastrointestinal Diseases	1	1
Gram-Negative Bacterial Infections	1	1
H5N1 Infection	1	1
HIV Drug-Induced Toxicity	1	1
HIV Infections	1	1
Human Papillomavirus (HPV)	1	1
Hyperglycemia	1	1
Influenza	1	1
Kidney Cancer	1	1
Liver Cirrhosis	1	1
Lung Cancer: Prevention	1	1
Melanoma	1	1
Neuroblastoma	1	1
Parkinson's Disease	1	1
Post-Traumatic Stress Disorders (PTSD)	1	1
Rhabdomyosarcoma	1	1
Skin Cancer	1	1
Skin Cancer: Prevention	1	1
Steptococcus Mutans Infections	1	1
Thyroid Cancer	1	1
Toxoplasma gondii Infection	1	1

Name	AC	CK	Focus
Low Dose Ionizing Radiation	1	2

Name	AC	CK
Curcumin	32	46
Broccoli Sprouts	3	22
Sulforaphane	3	21
Cannabinoids	3	16
Thymoquinone	8	16
Amurensin G	3	15
EGCG (Epigallocatechin gallate)	10	15
Black Raspberry	2	12
Delta-tetrahydrocannabinol (THC)	2	12
Flavonoids	7	12
Water: Deuterium Depleted	2	12
Garlic	2	11
Pycnogenol (Pine Bark)	1	10
Berberine	4	9
Polyphenols	6	9
Alpha-Lipoic Acid	3	8
Bacopa	4	8
Quercetin	3	8
Resveratrol	7	8
Vitamin D	5	8
Nigella sativa (aka Black Seed)	2	7
Propolis: Bee	2	7
Fish Oil	3	6
Kaempferol	2	6
Tomato	3	6
Turmeric	4	6
Astaxanthin	3	5
Bisdemethoxycurcumin	1	5
Mushrooms: All	1	5
Propolis: Brazillian	1	5
Lingonberry	2	4
Reishi Mushroom	3	4
Shiitake Mushroom	2	4
Vitamin C	3	4
Apigenin	2	3
Bee Venom	2	3
Curcuminoids	2	3
Folic Acid	2	3
Genistein	3	3
Ginger	3	3
Green Tea	2	3
Magnolia	2	3
Magnolol	2	3
Piperine	2	3
Pomegranate	3	3
Silibinin	2	3
Acai	1	2
Achiote	1	2
Astragalus	1	2
Betaine	1	2
Bilberry	1	2
Black Currant	1	2
Black Tea	1	2
Carvacrol	1	2
Chlorogenic Acid	1	2
Cinnamon	1	2
Cocoa	1	2
Coffee	1	2
Cryptoxanthin	1	2
Cucurbitacin B	1	2
DHA (Docosahexaenoic Acid)	2	2
EPA (Eicosapentaenoic Acid)	2	2
Ferulic acid	2	2
Flaxseed	1	2
Flaxseed Oil	1	2
Fucoidan	1	2
Gotu Kola	1	2
Green Coffee Bean	1	2
Honey	2	2
Huaier (Trametes robiniophila murr)	2	2
Krill	1	2
Licorice	1	2
Lignans	1	2
Lycopene	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mulberry	1	2
Noni leaf extract	1	2
Omega-3 Fatty Acids	1	2
Peach	1	2
Pectin	1	2
Plum	1	2
Red Wine	1	2
Rice Bran	1	2
Rice: Black	1	2
Rosemary	2	2
Seaweed	1	2
Selenium	1	2
Solanum Glaucophyllum	1	2
Tetrahydrocurcumin	1	2
Theophylline	1	2
Trichosanthes Kirilowii	1	2
Turmerones	1	2
Ursolic Acid	2	2
Vitamin D3	1	2
Walnut	1	2
Wogonin	1	2
Xanthohumol	1	2
Yarrow	1	2
beta-Carotene	1	2
6-Shogaol	1	1
Anthocyanins	1	1
Ashwagandha	1	1
Bacillus Clausii	1	1
Baicalein	1	1
Barberry	1	1
Bee Propolis	1	1
Camel Milk	1	1
Cannabidiol	1	1
Cannabis	1	1
Carnosic Acid	1	1
Catechin	1	1
Chokeberry	1	1
Cruciferous Vegetables	1	1
Daidzein	1	1
Diosgenin	1	1
Fenugreek	1	1
Fig	1	1
Fisetin	1	1
Garcinia cambogia	1	1
Ginsenosides	1	1
Guggul	1	1
Hibiscus	1	1
Homeopathic Medicine: All	1	1
Honokiol	1	1
Iodine	1	1
Lactobacillus probiotics	1	1
Lactobacillus reuteri	1	1
Lactobacillus rhamnosus	1	1
Lavender: Essential Oil	1	1
Lettuce	1	1
Mangiferin	1	1
Mangosteen	1	1
Manuka Honey	1	1
Maqui	1	1
Melatonin	1	1
Mustard Oil	1	1
Nobiletin	1	1
Oleocanthal	1	1
Oleuropein	1	1
Perilla	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Prickly Pear Cactus	1	1
Sweet Potato: Purple	1	1
Tamarind	1	1
Urolithin A	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin K2	1	1

Name	AC	CK
Exercise	2	12
Exercise: Endurance	1	10
Light-Emitting Diodes (LEDs) Therapy	1	2
Aromatherapy	1	1

Name	AC	CK
Apoptotic	44	102
Antiproliferative	49	88
Anti-Inflammatory Agents	35	78
Cell cycle arrest	26	50
Antioxidants	23	48
Chemopreventive	25	46
Anti-metastatic	21	34
Anticarcinogenic Agents	20	31
NF-kappaB Inhibitor	16	27
Antineoplastic Agents	8	26
Neuroprotective Agents	13	24
Immunomodulatory	9	23
Chemotherapeutic	7	22
MicroRNA modulator	12	21
Hepatoprotective	11	20
Hypolipidemic	10	19
Tumor Necrosis Factor (TNF) Alpha Inhibitor	11	19
Angiogenesis Inhibitors	5	16
Vascular Endothelial Growth Factor Inhibitors	4	15
Chemosensitizer	5	13
Cyclooxygenase 2 Inhibitors	8	11
Anti Inflammatory	1	10
Anticholesteremic Agents	5	10
Nrf2 activation	1	10
Cardioprotective	5	9
Enzyme Inhibitors	4	9
Interleukin-1 beta downregulation	4	8
Interleukin-6 Downregulation	5	8
Anti-Tumor	2	7
Hypoxia-inducible factor-1 (HIF-1) inhibitor	2	7
Vascular Endothelial Growth Factor A Inhibitor	2	7
Anti-Angiogenic	2	6
Superoxide Dismutase Up-regulation	3	6
Anti-Adipogenic	1	5
Antimicrobial	4	5
Antiviral Agents	4	5
Wnt/β-catenin signaling pathway modulation	3	5
Anti-atherogenic	2	4
Chondroprotective	2	4
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	4
Renoprotective	2	4
Anti-Apoptotic	2	3
Antioxidant Effects	2	3
Autophagy Inhibitors	2	3
Hypoglycemic Agents	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	3
Insulin Sensitizers	2	3
Nitric Oxide Inhibitor	2	3
Pancreato Protective Agents	2	3
Prophylactic Agents	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
Androgen Antagonists	1	2
Anti-Bacterial Agents	2	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Appetite Depressants	1	2
Bcl-2 protein down-regulation	2	2
Catalase Up-Regulation	1	2
Chemoprotective Agents	1	2
Cyclooxygenase Inhibitors	1	2
Fibroblast growth factor 21 upregulation	1	2
Gastroprotective	1	2
Genoprotective	1	2
Histone deacetylase inhibitor	1	2
Immunomodulatory: Th17 downregulation	1	2
Immunostimulatory	1	2
Interferon Gamma Reducer	1	2
Malondialdehyde Down-regulation	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
Matrix Metalloproteinases Inhibitors	1	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	2
Osteogenic	1	2
Phase I Detoxification Enzyme Inducer	1	2
Phase II Detoxification Enzyme Inducer	1	2
Proteasome Inhibitors	1	2
Radioprotective	1	2
Radiosensitizer	2	2
Remyelination	1	2
SIRT1 Activator	1	2
anti-inflammatory	1	2
Antioxidant	1	1
Antiparasitic Agents	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Cytotoxic	1	1
DNA Repair Up-regulation	1	1
Estradiol Antagonists	1	1
Glutathione S-transferase Inhibitor	1	1
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	1
Heme oxygenase-1 up-regulation	1	1
Interleukin-10 downregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
Neurogenesis	1	1
P16 Activation	1	1
P21 Activation	1	1
Phosphodiesterase Inhibitors	1	1
STAT3 Inhibitor	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vitamin D Receptor (VDR) Modulator	1	1

[+]

Aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.Aug 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Endurance training positively affects thousands of DNA methylation sites and genes which leads to improvement in muscle function and health.Dec 01, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Epigenetics. 2014 Dec 2 ;9(12):1557-69. PMID: 25484259

Article Published Date : Dec 01, 2014

Study Type : Human Study

Additional Links

Therapeutic Actions : Exercise: Endurance

Pharmacological Actions : Anti Inflammatory

Additional Keywords : DNA Methylation, Epigenetic Modification, Gene Expression Regulation

[+]

Fish oil supplementation for 6 weeks in women with gestational diabetes significantly improved gene expression of PPAR-γ, IL-1, and TNF-α.Jan 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Jan 31 ;10(2). Epub 2018 Jan 31. PMID: 29385062

Article Published Date : Jan 30, 2018

Study Type : Human Study

Additional Links

Substances : Fish Oil

Diseases : Diabetes: Gestational, Gestational Diabetes

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Gene Expression Regulation

[+]

Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.May 24, 2019

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Pubmed Data : Gene. 2019 May 25 ;698:179-185. Epub 2019 Mar 4. PMID: 30844477

Article Published Date : May 24, 2019

Study Type : Human Study

Additional Links

Substances : Ginger

Diseases : Inflammation, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

Additional Keywords : Gene Expression Regulation, Phytotherapy, Plant Extracts

[+]

[+]

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID: 25625225

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Nutr. 2020 Jan 6:1-26. Epub 2020 Jan 6. PMID: 31902378

Article Published Date : Jan 05, 2020

Study Type : Human Study

Additional Links

Substances : Flaxseed, Omega-3 Fatty Acids

Diseases : Gestational Diabetes

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation

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Additional Keywords : Gene Expression Regulation

[+]

The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

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[+]

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Tradit Chin Med. 2014 Jun ;34(3):302-8. PMID: 24992757

Article Published Date : May 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Berberine

Diseases : Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Enzyme Inhibitors, MicroRNA modulator

Additional Keywords : Chinese Herbs, Gene Expression Regulation

[+]

Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.Jan 10, 2015

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Pubmed Data : In Vivo. 2015 11-12;29(6):711-728. PMID: 26546528

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID: 26401074

Curcumin could be a potential leading compound for development of drugs for the prevention of obesity and insulin resistance.May 17, 2016

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Pubmed Data : Toxicol Appl Pharmacol. 2016 May 18. Epub 2016 May 18. PMID: 27208389

Article Published Date : May 17, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : High Fat Diet, Insulin Resistance, Obesity

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation

[+]

Curcumin effectively attenuates brain edema in mice with ICH through inhibition of the NF-κB pathway and subsequently the expression of AQP4 and AQP9.Jun 28, 2015

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Pubmed Data : Acta Pharmacol Sin. 2015 Jun 29. Epub 2015 Jun 29. PMID: 26119880

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Pubmed Data : J Nutr. 2016 Mar 9. Epub 2016 Mar 9. PMID: 26962192

Article Published Date : Mar 08, 2016

Study Type : Animal Study

Additional Links

Substances : Selenium

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Gene Expression Regulation

[+]

Dietary supplementation with dried plum may prevent the skeletal effects of radiation exposures either in space or on Earth.Dec 31, 2015

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Pubmed Data : J Food Sci. 2015 Dec ;80(12):M2925-31. Epub 2015 Nov 10. PMID: 26556797

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Clostridium Infections

Pharmacological Actions : Antimicrobial, Gastroprotective

Additional Keywords : Gene Expression Regulation

[+]

EGCG induces miRNA profile changes in the NNK-induced A/J mouse lung tumor.Dec 31, 2013

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Pubmed Data : BMC Genomics. 2014 ;15 Suppl 11:S3. Epub 2014 Dec 16. PMID: 25559244

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Pubmed Data : Fish Shellfish Immunol. 2017 Jun 22. Epub 2017 Jun 22. PMID: 28648884

Article Published Date : Jun 21, 2017

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Fish Diseases

Additional Keywords : Gene Expression Regulation

[+]

EGCG modulates the reversal of gene silencing involved in colon carcinogenesis.May 05, 2016

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Pubmed Data : Oncotarget. 2016 May 6. Epub 2016 May 6. PMID: 27167203

Article Published Date : May 05, 2016

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Dose Response, Epigenetic Modification In Cancer, Gene Expression Regulation

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Pubmed Data : J Nutrigenet Nutrigenomics. 2017 ;10(1-2):19-31. Epub 2017 Apr 12. PMID: 28399529

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Resveratrol may contribute towards the protection of hepatic cells from ethanol-induced oxidative stress.Mar 31, 2016

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Pubmed Data : Exp Ther Med. 2016 Apr ;11(4):1231-1238. Epub 2016 Feb 16. PMID: 27073428

Article Published Date : Mar 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Alcohol Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Gene Expression Regulation

[+]

Routine consumption of guarana might be beneficial in protecting against mercury-induced toxicity.Oct 31, 2016

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Pubmed Data : Toxicol Res (Camb). 2016 Nov 1 ;5(6):1629-1638. Epub 2016 Aug 24. PMID: 28316775

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cell Biochem. 2019 Nov 26. Epub 2019 Nov 26. PMID: 31769066

Article Published Date : Nov 25, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shikonin

Diseases : Lung Injury: Acute, Sepsis

Pharmacological Actions : MicroRNA modulator

Additional Keywords : Gene Expression Regulation

[+]

Silibinin can modulate TI-induced FAT10 expression and also restores normal chromosome numbers to cells treated with TI.Jul 02, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Open. 2015 Jul 3. Epub 2015 Jul 3. PMID: 26142316

The present study demonstrates potential beneficial effects of metformin and flax/fish oil intervention in improving serum lipid profile.Dec 31, 2015

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Pubmed Data : Genes Nutr. 2016 ;11:10. Epub 2016 Mar 17. PMID: 27551311

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Fish Oil, Flaxseed Oil, Omega-3 Fatty Acids

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Hypolipidemic

Additional Keywords : Gene Expression Regulation

[+]

The present study indicates that BCX is a preventive agent against emphysema and lung cancer with SIRT1 as a potential target.Mar 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Prev Res (Phila). 2013 Apr ;6(4):309-20. Epub 2012 Dec 28. PMID: 23275008

Article Published Date : Mar 31, 2013

Study Type : Animal Study

Additional Links

Substances : Cryptoxanthin

Diseases : Lung Cancer, Nicotine/Tobacco Toxicity , Pulmonary Emphysema

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, SIRT1 Activator

Additional Keywords : Gene Expression Regulation, Risk Reduction

[+]

These data provided an insight into understanding the molecular mechanisms underlying the effect of ginsenoside Rg3 treatment of diabetic nephropathy.Jul 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2016 Aug ;14(2):1162-72. Epub 2016 May 27. PMID:

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Aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.Aug 31, 2015

B12 supplementation influences regulation of several metabolically important Type 2 diabetes-associated genes through methylation of miR21.Nov 13, 2017

Brain education-based meditation helps lower LDL cholesterol level and the inflammatory gene expression in patients with hypertension or T2D.Apr 30, 2019

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α.Sep 25, 2017

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

Endurance training positively affects thousands of DNA methylation sites and genes which leads to improvement in muscle function and health.Dec 01, 2014

Fish oil supplementation for 6 weeks in women with gestational diabetes significantly improved gene expression of PPAR-γ, IL-1, and TNF-α.Jan 30, 2018

Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.May 24, 2019

Lactobacillus gasseri CP2305 administration is a potential candidate therapeutic option for patients with IBS.Dec 31, 2016

Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne.Nov 29, 2016

Magnesium and zinc co-supplementation for 12 weeks among women with PCOS had beneficial effects on inflammation and oxidative stress. Nov 09, 2017

Maternal gene expression changes during pregnancy and that these changes are related to vitamin D levels.Dec 31, 2015

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Mindfulness meditation reduces intraocular pressure, lowers stress biomarkers and modulates gene expression in glaucoma.Nov 30, 2018

Omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-γ and LDLR.Feb 23, 2017

Omega-3 fatty acids supplementation for 6 weeks to women with gestational diabetes mellitus had beneficial effects.Jan 05, 2020

Oral Shilajit supplementation in adult overweight/class I obese human subjects promoted skeletal muscle adaptation.Jun 30, 2016

Prolonged periods of sedentary behavior are associated with significantly lower BRCA1 mRNA expression.Nov 01, 2015

Spa therapy induces clinical improvement and protein changes in patients with chronic back pain.Oct 23, 2019

Sudarshan Kriya practice may exert effects on immunity, aging, cell death, and stress regulation through transcriptional regulation.Jan 31, 2008

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche.Dec 22, 2015

Taking myo-inositol by women with PCOS had beneficial effects on glycemic control, triglycerides and VLDL-cholesterol levels, and gene expression of PPAR-γ.Jan 03, 2019

The bioactivity of garlic is multifaceted and includes activation of genes related to immunity, apoptosis, and xenobiotic metabolism in humans and Mono Mac 6 cells.Sep 29, 2015

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia.Dec 31, 2018

The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.Dec 31, 2012

Third-trimester high-dose vitD3 supplementation in healthy pregnant women had balanced effects on biomarkers of cord blood Th1 and Th2 responses.Dec 31, 2015

Transcriptomic profile of whole blood cells from elderly subjects fed probiotic bacteria Lactobacillus rhamnosus GG.Dec 31, 2015

ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory CXCL2 gene in humans.Sep 30, 2012

Upregulation of vitamin D-related genes in schizophrenic patients.Dec 31, 2017

Vitamin C supplementation has beneficial effects for the male partners of couples with recurrent pregnancy loss could lead to improved pregnancy outcomes.Feb 29, 2020

Vitamin D supplementation may have a beneficial role in ulcerative colitis patients.Jun 30, 2016

Yogic practices have rapid effects at the molecular level in circulating immune cells.Dec 31, 2012

Alpha-lipoic acid could be a therapeutic agent because of its inhibitory effects on ROS production, inflammation, and adipose tissue expansionDec 31, 2015

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Amurensin G had significant antiangiogenic and antitumor growth effects in tamoxifen resistant breast cancer.Sep 30, 2012

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.Jan 10, 2015

In utero bisphenol A exposure is linked with sex specific changes in the transcriptome and methylome of human amniocytes.Sep 18, 2019

LED irradiation promoted elastin gene expression more in elderly than in younger adults.Mar 31, 2016

Malaysian and Brazilian red propolis show potential to assist in wound healing.Dec 31, 2014

Psoralea corylifolia induces apoptosis and autophagy and alteres genes expression assayed by cDNA microarray in human prostate cancer PC-3 cells.Jun 30, 2018

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes.Oct 24, 2017

The proapoptotic effect of cannabinoids on tumor cells is mediated by a ceramide dependent upregulation of the stress protein p8.Mar 31, 2006

These results provide important new data for ellagic acid in anti-colorectal carcinoma research.Jan 31, 2017

Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.Dec 31, 2015

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

Vitamin C modulated the immune system.Mar 22, 2017

10% pectin supplementation for one month in adult rats decreases body-fat content and ameliorates age-related insulin and leptin resistance.Jul 21, 2015

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

A cucurbitane type triterpenoid compound from Momordica charantia alleviated diabetic metabolic symptoms in alloxan induced diabetic mice.Oct 31, 2016

A hot water extract from wasabi leaves induces mild suppression of obesity in a high-fat diet induced mice.Jul 31, 2013

A Polysaccharide from black current is effective in preventing and alleviating the development of atopic dermatitis-like skin disease.Dec 31, 2017

A thymoquinone-rich fraction extracted from Nigella sativa effectively improved the plasma and liver antioxidant capacity.Feb 28, 2010

A. brasiliensis improves the serum lipid profile in hypercholesterolemic rats May 04, 2016

Achillea Millefolium hydro alcoholic extract protects pancreatic cells.Dec 31, 2013

Additive effect of walnut and chokeberry on regulation of antioxidant enzyme gene expression and attenuation of lipid peroxidation.Oct 03, 2018

Administering ubiquinol 30 min before traumatic brain injury significantly affected cerebral gene expression profiles.Jun 30, 2017

Administration of Moringa oleifera extract mitigated cyclophosphamide-induced testicular damage.May 14, 2020

Alliin alters gut microbiota and gene expression of colonic epithelial tissues.Mar 31, 2019

Allium hookeri root extract inhibits adipogenesis by promoting lipolysis in high fat diet-induced obese mice.Sep 19, 2019

Alpha-lipoic acid can alleviate acute inflammatory response in animals. Aug 15, 2016

Alternating consumption of β-glucan and quercetin reduces mortality in mice with colorectal cancer.Sep 30, 2019

An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells.Dec 31, 2014

An extract of Bacopa monniera effectively protects the kidney from hypercholesterolemia-mediated oxido-lipidemic damage.Sep 30, 2014

An extract of Bacopa monnieri restored the memory in CoCl2-hypoxia mimetic mice.Dec 31, 2014

An extract of black ginseng ameliorated hypercholesterolemia in rats fed a high-cholesterol diet.Mar 31, 2016

Angelica sinensis suppresses body weight gain and alters expression of the FTO Gene in high-fat-diet induced obesity. Dec 31, 2016

Annatto extract and β-carotene enhances antioxidant status and regulate gene expression in neutrophils of diabetic rats.Feb 29, 2012

Gene Expression Regulation

View the Evidence:
466 Abstracts with Gene Expression Regulation Research