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Gene Expression Regulation
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5 Problem Substances Researched for Gene Expression Regulation
Name
AC
CK
Focus
Doxorubicin
1
5
Acetaminophen
1
2
Pesticides
1
2
Meat: Cooked
1
1
Polycyclic aromatic hydrocarbon
1
1
152 Diseases Researched for Gene Expression Regulation
Name
AC
CK
Focus
Breast Cancer
18
36
Lung Cancer
14
36
Oxidative Stress
12
34
Inflammation
10
24
Prostate Cancer
13
21
Colon Cancer
11
19
Obesity
11
19
Carcinoma: Non-Small-Cell Lung
6
18
High Fat Diet
8
16
Cancers: Drug Resistant
6
15
Cancers: All
8
14
Oral Cancer
2
11
Anemia: Sickle Cell
1
10
Asthma
1
10
Breast Cancer: BRCA1
1
10
Breast Cancer: Drug Resistant
2
10
Carcinoma: Small Cell Lung
1
10
Fibrosarcoma
1
10
Glioblastoma Multiforme
1
10
Leukemia: Monocytic
1
10
Lung Cancer: Metastatic
1
10
Sitting Sickness
1
10
Alzheimer's Disease
6
9
Breast Cancer: Triple Negative
9
9
Colorectal Cancer
7
9
Hypercholesterolemia
4
8
DNA damage
3
7
Diabetes Mellitus: Type 2
4
7
Insulin Resistance
4
7
Atherosclerosis
3
6
Cancer Metastasis
3
6
Cognitive Decline/Dysfunction
3
6
Memory Loss
3
6
Metabolic Diseases
3
6
Astrocytoma
1
5
Breast Cancer: Metastatic
3
5
Cervical Cancer
5
5
Colon Cancer: Prevention
3
5
Glioblastoma
1
5
Graves Disease
1
5
Hydrogen Peroxide Induced Toxicity
1
5
Leukemia: Chronic myelogenous leukemia (CML)
1
5
Non-Small-Cell Lung Carcinoma
1
5
Nonalcoholic fatty liver disease (NAFLD)
3
5
Osteoarthritis
3
5
Wound Healing
1
5
Bladder Cancer
3
4
Cachexia
2
4
Diabetes Mellitus: Type 1
2
4
Down Syndrome
2
4
Hyperlipidemia
2
4
Liver Cancer
3
4
Multiple Sclerosis
2
4
Pancreatic Cancer
3
4
Triglycerides: Elevated
2
4
Breast Cancer: Chemically-Induced
2
3
Breast Cancer: Lung Metastasis
2
3
Dementia
2
3
Leukemia
2
3
Lipid Peroxidation
2
3
Osteoporosis
2
3
Ovarian Cancer
3
3
Prostate Cancer: Prevention
2
3
Acetaminophen (Tylenol) Toxicity
1
2
Acute Myeloid Leukemia
2
2
Acute Respiratory Distress Syndrome
1
2
Aging
1
2
Alcohol Toxicity
1
2
Alcoholic Liver Disease
1
2
Amnesia
1
2
Autoimmune Diseases
1
2
Brain Edema
1
2
Brain Hypoxia
1
2
Cachexia: Cancer
1
2
Cachexia: Chemotherapy Induced
1
2
Cancers: Radiation-Resistant
1
2
Chemically-Induced Liver Damage
1
2
Chronic Kidney Disease (CKD)
1
2
Clostridium Infections
1
2
Demyelinating Diseases
1
2
Diabetes Mellitus: Type 2: Prevention
1
2
Diabetic Nephropathy
1
2
Dysbiosis: Bifidobacteria Deficiency
1
2
Encephalomyelitis
1
2
Epilepsy
1
2
Heart Failure
1
2
Hepatic Steatosis
1
2
Hepatitis C
1
2
Inflammatory Bowel Diseases
1
2
Intracerebral Hemorrhage
1
2
Kidney Fibrosis
1
2
Lipopolysaccharide-Induced Toxicity
1
2
Liver Damage: Aflatoxin-Induced
1
2
Liver Steatosis
1
2
Lung Injury: Acute
1
2
Memory Disorders
1
2
Muscle Atrophy
1
2
Nicotine/Tobacco Toxicity
1
2
Periodontitis
1
2
Prediabetes
1
2
Pseudomonas aeruginosa
2
2
Pulmonary Emphysema
1
2
Pulmonary Fibrosis
1
2
Rheumatoid Arthritis
1
2
Seizures
1
2
Snake Bite: Venom Toxicity
1
2
Staphylococcus aureus: Methicillin-resistant (MRSA)
2
2
Stress
1
2
Stroke: Attenuation/Recovery
1
2
Systemic Lupus Erythematosus
1
2
Ultraviolet Radiation Induced Damage
1
2
Vitamin D Deficiency
1
2
Werner Syndrome
1
2
AIDS
1
1
Advanced Glycation End products (AGE)
1
1
Avian Influenza
1
1
Bile Duct Cancer
1
1
Bone Diseases
1
1
Bone Fractures
1
1
Brain Cancer
1
1
Breast Cancer: HER-2 Overexpressed
1
1
Candidiasis: Vulvovaginal
1
1
Cardiovascular Diseases
1
1
Chemotherapy-Induced Toxicity: Cisplatin
1
1
Cholangiocarcinoma
1
1
Chronic Myeloid Leukemia
1
1
Cytomegalovirus Infections
1
1
Endometrial Cancer
1
1
Esophageal Cancer
1
1
Fibrosis
1
1
Gastric Cancer
1
1
Gastrointestinal Diseases
1
1
Gram-Negative Bacterial Infections
1
1
H5N1 Infection
1
1
HIV Drug-Induced Toxicity
1
1
HIV Infections
1
1
Human Papillomavirus (HPV)
1
1
Hyperglycemia
1
1
Influenza
1
1
Kidney Cancer
1
1
Liver Cirrhosis
1
1
Lung Cancer: Prevention
1
1
Melanoma
1
1
Neuroblastoma
1
1
Parkinson's Disease
1
1
Post-Traumatic Stress Disorders (PTSD)
1
1
Rhabdomyosarcoma
1
1
Skin Cancer
1
1
Skin Cancer: Prevention
1
1
Steptococcus Mutans Infections
1
1
Thyroid Cancer
1
1
Toxoplasma gondii Infection
1
1
1 Problematic Actions Researched for Gene Expression Regulation
Name
AC
CK
Focus
Low Dose Ionizing Radiation
1
2
147 Substances Researched for Gene Expression Regulation
Name
AC
CK
Focus
Curcumin
32
46
Broccoli Sprouts
3
22
Sulforaphane
3
21
Cannabinoids
3
16
Thymoquinone
8
16
Amurensin G
3
15
EGCG (Epigallocatechin gallate)
10
15
Black Raspberry
2
12
Delta-tetrahydrocannabinol (THC)
2
12
Flavonoids
7
12
Water: Deuterium Depleted
2
12
Garlic
2
11
Pycnogenol (Pine Bark)
1
10
Berberine
4
9
Polyphenols
6
9
Alpha-Lipoic Acid
3
8
Bacopa
4
8
Quercetin
3
8
Resveratrol
7
8
Vitamin D
5
8
Nigella sativa (aka Black Seed)
2
7
Propolis: Bee
2
7
Fish Oil
3
6
Kaempferol
2
6
Tomato
3
6
Turmeric
4
6
Astaxanthin
3
5
Bisdemethoxycurcumin
1
5
Mushrooms: All
1
5
Propolis: Brazillian
1
5
Lingonberry
2
4
Reishi Mushroom
3
4
Shiitake Mushroom
2
4
Vitamin C
3
4
Apigenin
2
3
Bee Venom
2
3
Curcuminoids
2
3
Folic Acid
2
3
Genistein
3
3
Ginger
3
3
Green Tea
2
3
Magnolia
2
3
Magnolol
2
3
Piperine
2
3
Pomegranate
3
3
Silibinin
2
3
Acai
1
2
Achiote
1
2
Astragalus
1
2
Betaine
1
2
Bilberry
1
2
Black Currant
1
2
Black Tea
1
2
Carvacrol
1
2
Chlorogenic Acid
1
2
Cinnamon
1
2
Cocoa
1
2
Coffee
1
2
Cryptoxanthin
1
2
Cucurbitacin B
1
2
DHA (Docosahexaenoic Acid)
2
2
EPA (Eicosapentaenoic Acid)
2
2
Ferulic acid
2
2
Flaxseed
1
2
Flaxseed Oil
1
2
Fucoidan
1
2
Gotu Kola
1
2
Green Coffee Bean
1
2
Honey
2
2
Huaier (Trametes robiniophila murr)
2
2
Krill
1
2
Licorice
1
2
Lignans
1
2
Lycopene
1
2
Mucuna pruriens (aka Velvet Beans)
1
2
Mulberry
1
2
Noni leaf extract
1
2
Omega-3 Fatty Acids
1
2
Peach
1
2
Pectin
1
2
Plum
1
2
Red Wine
1
2
Rice Bran
1
2
Rice: Black
1
2
Rosemary
2
2
Seaweed
1
2
Selenium
1
2
Solanum Glaucophyllum
1
2
Tetrahydrocurcumin
1
2
Theophylline
1
2
Trichosanthes Kirilowii
1
2
Turmerones
1
2
Ursolic Acid
2
2
Vitamin D3
1
2
Walnut
1
2
Wogonin
1
2
Xanthohumol
1
2
Yarrow
1
2
beta-Carotene
1
2
6-Shogaol
1
1
Anthocyanins
1
1
Ashwagandha
1
1
Bacillus Clausii
1
1
Baicalein
1
1
Barberry
1
1
Bee Propolis
1
1
Camel Milk
1
1
Cannabidiol
1
1
Cannabis
1
1
Carnosic Acid
1
1
Catechin
1
1
Chokeberry
1
1
Cruciferous Vegetables
1
1
Daidzein
1
1
Diosgenin
1
1
Fenugreek
1
1
Fig
1
1
Fisetin
1
1
Garcinia cambogia
1
1
Ginsenosides
1
1
Guggul
1
1
Hibiscus
1
1
Homeopathic Medicine: All
1
1
Honokiol
1
1
Iodine
1
1
Lactobacillus probiotics
1
1
Lactobacillus reuteri
1
1
Lactobacillus rhamnosus
1
1
Lavender: Essential Oil
1
1
Lettuce
1
1
Mangiferin
1
1
Mangosteen
1
1
Manuka Honey
1
1
Maqui
1
1
Melatonin
1
1
Mustard Oil
1
1
Nobiletin
1
1
Oleocanthal
1
1
Oleuropein
1
1
Perilla
1
1
Polyunsaturated Fatty Acids (PUFAs)
1
1
Prickly Pear Cactus
1
1
Sweet Potato: Purple
1
1
Tamarind
1
1
Urolithin A
1
1
Vitamin E: Gamma-tocotrienol
1
1
Vitamin K2
1
1
4 Therapeutic Actions Researched for Gene Expression Regulation
Name
AC
CK
Focus
Exercise
2
12
Exercise: Endurance
1
10
Light-Emitting Diodes (LEDs) Therapy
1
2
Aromatherapy
1
1
103 Pharmacological Actions Researched for Gene Expression Regulation
Name
AC
CK
Focus
Apoptotic
44
102
Antiproliferative
49
88
Anti-Inflammatory Agents
35
78
Cell cycle arrest
26
50
Antioxidants
23
48
Chemopreventive
25
46
Anti-metastatic
21
34
Anticarcinogenic Agents
20
31
NF-kappaB Inhibitor
16
27
Antineoplastic Agents
8
26
Neuroprotective Agents
13
24
Immunomodulatory
9
23
Chemotherapeutic
7
22
MicroRNA modulator
12
21
Hepatoprotective
11
20
Hypolipidemic
10
19
Tumor Necrosis Factor (TNF) Alpha Inhibitor
11
19
Angiogenesis Inhibitors
5
16
Vascular Endothelial Growth Factor Inhibitors
4
15
Chemosensitizer
5
13
Cyclooxygenase 2 Inhibitors
8
11
Anti Inflammatory
1
10
Anticholesteremic Agents
5
10
Nrf2 activation
1
10
Cardioprotective
5
9
Enzyme Inhibitors
4
9
Interleukin-1 beta downregulation
4
8
Interleukin-6 Downregulation
5
8
Anti-Tumor
2
7
Hypoxia-inducible factor-1 (HIF-1) inhibitor
2
7
Vascular Endothelial Growth Factor A Inhibitor
2
7
Anti-Angiogenic
2
6
Superoxide Dismutase Up-regulation
3
6
Anti-Adipogenic
1
5
Antimicrobial
4
5
Antiviral Agents
4
5
Wnt/β-catenin signaling pathway modulation
3
5
Anti-atherogenic
2
4
Chondroprotective
2
4
Matrix metalloproteinase-3 (MMP-3) inhibitor
2
4
Renoprotective
2
4
Anti-Apoptotic
2
3
Antioxidant Effects
2
3
Autophagy Inhibitors
2
3
Hypoglycemic Agents
2
3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
2
3
Insulin Sensitizers
2
3
Nitric Oxide Inhibitor
2
3
Pancreato Protective Agents
2
3
Prophylactic Agents
2
3
Tumor Suppressor Protein p53 Upregulation
3
3
Androgen Antagonists
1
2
Anti-Bacterial Agents
2
2
Anticonvulsants
1
2
Antidepressive Agents
1
2
Appetite Depressants
1
2
Bcl-2 protein down-regulation
2
2
Catalase Up-Regulation
1
2
Chemoprotective Agents
1
2
Cyclooxygenase Inhibitors
1
2
Fibroblast growth factor 21 upregulation
1
2
Gastroprotective
1
2
Genoprotective
1
2
Histone deacetylase inhibitor
1
2
Immunomodulatory: Th17 downregulation
1
2
Immunostimulatory
1
2
Interferon Gamma Reducer
1
2
Malondialdehyde Down-regulation
1
2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
1
2
Matrix Metalloproteinases Inhibitors
1
2
Matrix metalloproteinase-1 (MMP-1) inhibitor
1
2
Matrix metalloproteinase-9 (MMP-9) inhibitor
2
2
Osteogenic
1
2
Phase I Detoxification Enzyme Inducer
1
2
Phase II Detoxification Enzyme Inducer
1
2
Proteasome Inhibitors
1
2
Radioprotective
1
2
Radiosensitizer
2
2
Remyelination
1
2
SIRT1 Activator
1
2
anti-inflammatory
1
2
Antioxidant
1
1
Antiparasitic Agents
1
1
Cyclin D1 Down-Regulation
1
1
Cyclin-dependent kinase inhibitor: P16INK4
1
1
Cytotoxic
1
1
DNA Repair Up-regulation
1
1
Estradiol Antagonists
1
1
Glutathione S-transferase Inhibitor
1
1
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor
1
1
Heme oxygenase-1 up-regulation
1
1
Interleukin-10 downregulation
1
1
Matrix metalloproteinase-2 (MMP-2) inhibitor
1
1
NF-E2-Related Factor-2 (Nrf2) Modulator
1
1
Neurogenesis
1
1
P16 Activation
1
1
P21 Activation
1
1
Phosphodiesterase Inhibitors
1
1
STAT3 Inhibitor
1
1
Survivin Down-Regulation
1
1
Telomerase Inhibitor
1
1
Transforming growth factor beta (TGF-β) inhibitor
1
1
Vitamin D Receptor (VDR) Modulator
1
1
Research Articles
214
Cumulative Knowledge Score
346
Overall Research Rating
GREAT
View the Evidence:
501 Abstracts with Gene Expression Regulation Research
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[+]
Acute effects of the consumption of Passiflora setacea juice on metabolic risk factors and gene expression profile in humans.
Apr 15, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2020 Apr 16 ;12(4). Epub 2020 Apr 16. PMID:
32316129
Article Published Date
: Apr 15, 2020
Study Type
: Human Study
Additional Links
Substances
:
Passion Flower
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Gerontol. 2015 Sep ;69:159-69. Epub 2015 May 15. PMID:
25981742
Article Published Date
: Aug 31, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Inflammation
Therapeutic Actions
:
Exercise: Aerobic
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
B12 supplementation influences regulation of several metabolically important Type 2 diabetes-associated genes through methylation of miR21.
Nov 13, 2017
Click here to read the entire abstract
Pubmed Data
: Epigenomics. 2017 Nov 14. Epub 2017 Nov 14. PMID:
29135286
Article Published Date
: Nov 13, 2017
Study Type
: Human Study
Additional Links
Substances
:
Vitamin B-12
Diseases
:
Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions
:
MicroRNA modulator
Additional Keywords
:
Epigenetic Modification
,
Gene Expression Regulation
[+]
Brain education-based meditation helps lower LDL cholesterol level and the inflammatory gene expression in patients with hypertension or T2D.
Apr 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Medicine (Baltimore). 2019 May ;98(19):e15574. PMID:
31083232
Article Published Date
: Apr 30, 2019
Study Type
: Human Study
Additional Links
Diseases
:
Diabetes Mellitus: Type 2
,
Hypertension
,
Inflammation
Therapeutic Actions
:
Meditation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticholesteremic Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(4):e0152895. Epub 2016 Apr 12. PMID:
27071063
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Anemia: Sickle Cell
Additional Keywords
:
Gene Expression Regulation
[+]
CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α.
Sep 25, 2017
Click here to read the entire abstract
Pubmed Data
: Gynecol Endocrinol. 2017 Sep 26:1-6. Epub 2017 Sep 26. PMID:
28949260
Article Published Date
: Sep 25, 2017
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.
Aug 14, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Res. 2004 Aug 15 ;64(16):5617-23. PMID:
15313899
Article Published Date
: Aug 14, 2004
Study Type
: Animal Study, Human Study
Additional Links
Substances
:
Cannabinoids
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Glioblastoma Multiforme
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Gene Expression Regulation
[+]
Endurance training positively affects thousands of DNA methylation sites and genes which leads to improvement in muscle function and health.
Dec 01, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epigenetics. 2014 Dec 2 ;9(12):1557-69. PMID:
25484259
Article Published Date
: Dec 01, 2014
Study Type
: Human Study
Additional Links
Therapeutic Actions
:
Exercise: Endurance
Pharmacological Actions
:
Anti Inflammatory
Additional Keywords
:
DNA Methylation
,
Epigenetic Modification
,
Gene Expression Regulation
[+]
Fish oil supplementation for 6 weeks in women with gestational diabetes significantly improved gene expression of PPAR-γ, IL-1, and TNF-α.
Jan 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2018 Jan 31 ;10(2). Epub 2018 Jan 31. PMID:
29385062
Article Published Date
: Jan 30, 2018
Study Type
: Human Study
Additional Links
Substances
:
Fish Oil
Diseases
:
Diabetes: Gestational
,
Gestational Diabetes
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.
May 24, 2019
Click here to read the entire abstract
Pubmed Data
: Gene. 2019 May 25 ;698:179-185. Epub 2019 Mar 4. PMID:
30844477
Article Published Date
: May 24, 2019
Study Type
: Human Study
Additional Links
Substances
:
Ginger
Diseases
:
Inflammation
,
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
,
Phytotherapy
,
Plant Extracts
[+]
Indole-3-carbinol could modulate the gene expression involved in wound healing in systemic lupus erythematosus cases and healthy controls.
Jun 30, 2020
Click here to read the entire abstract
Pubmed Data
: Lupus. 2020 Jul ;29(8):954-963. Epub 2020 Jun 9. PMID:
32517571
Article Published Date
: Jun 30, 2020
Study Type
: Human In Vitro, Human Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Systemic Lupus Erythematosus
,
Wound Healing
Additional Keywords
:
Gene Expression Regulation
[+]
Lactobacillus gasseri CP2305 administration is a potential candidate therapeutic option for patients with IBS.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Appl Microbiol. 2017 Jan ;122(1):212-224. PMID:
27761980
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Lactobacillus gasseri
Diseases
:
Irritable Bowel Syndrome
Additional Keywords
:
Gene Expression Regulation
[+]
Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation.
Feb 16, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2021 Feb 17 ;11(1):3972. Epub 2021 Feb 17. PMID:
33597583
Article Published Date
: Feb 16, 2021
Study Type
: Human Study
Additional Links
Substances
:
Lactobacillus plantarum
Diseases
:
Coronary Artery Disease
,
Endothelial Dysfunction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-12 downregulation
,
Interleukin-8 downregulation
Additional Keywords
:
Gene Expression Regulation
[+]
Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne.
Nov 29, 2016
Click here to read the entire abstract
Pubmed Data
: Benef Microbes. 2016 Nov 30 ;7(5):625-630. Epub 2016 Sep 6. PMID:
27596801
Article Published Date
: Nov 29, 2016
Study Type
: Human Study
Additional Links
Diseases
:
Acne
Additional Keywords
:
Gene Expression Regulation
[+]
Magnesium and zinc co-supplementation for 12 weeks among women with PCOS had beneficial effects on inflammation and oxidative stress.
Nov 09, 2017
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2017 Nov 10. Epub 2017 Nov 10. PMID:
29127547
Article Published Date
: Nov 09, 2017
Study Type
: Human Study
Additional Links
Substances
:
Magnesium
,
Zinc
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Maternal gene expression changes during pregnancy and that these changes are related to vitamin D levels.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(10):e0163832. Epub 2016 Aug 6. PMID:
27711190
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Vitamin D
Diseases
:
Vitamin D Deficiency
Additional Keywords
:
Gene Expression Regulation
[+]
Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID:
25625225
Article Published Date
: Mar 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Pycnogenol (Pine Bark)
Diseases
:
Fibrosarcoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Mindfulness meditation reduces intraocular pressure, lowers stress biomarkers and modulates gene expression in glaucoma.
Nov 30, 2018
Click here to read the entire abstract
Pubmed Data
: J Glaucoma. 2018 Dec ;27(12):1061-1067. PMID:
30256277
Article Published Date
: Nov 30, 2018
Study Type
: Human Study
Additional Links
Diseases
:
Glaucoma
Therapeutic Actions
:
Meditation
,
Mindfullness Training
Additional Keywords
:
Gene Expression Regulation
[+]
Omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-γ and LDLR.
Feb 23, 2017
Click here to read the entire abstract
Pubmed Data
: Horm Metab Res. 2017 Feb 24. Epub 2017 Feb 24. PMID:
28235206
Article Published Date
: Feb 23, 2017
Study Type
: Human Study
Additional Links
Substances
:
Omega-3 Fatty Acids
Diseases
:
Polycystic Ovary Syndrome
Additional Keywords
:
Gene Expression Regulation
[+]
Omega-3 fatty acids supplementation for 6 weeks to women with gestational diabetes mellitus had beneficial effects.
Jan 05, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Br J Nutr. 2020 Jan 6:1-26. Epub 2020 Jan 6. PMID:
31902378
Article Published Date
: Jan 05, 2020
Study Type
: Human Study
Additional Links
Substances
:
Flaxseed
,
Omega-3 Fatty Acids
Diseases
:
Gestational Diabetes
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Oral Shilajit supplementation in adult overweight/class I obese human subjects promoted skeletal muscle adaptation.
Jun 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Food. 2016 Jul ;19(7):701-9. PMID:
27414521
Article Published Date
: Jun 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
Shilajit
Diseases
:
Obesity
Additional Keywords
:
Gene Expression Regulation
[+]
Prolonged periods of sedentary behavior are associated with significantly lower BRCA1 mRNA expression.
Nov 01, 2015
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2015 Nov 2. Epub 2015 Nov 2. PMID:
26526989
Article Published Date
: Nov 01, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer
,
Breast Cancer: BRCA1
,
Sitting Sickness
Therapeutic Actions
:
Exercise
Additional Keywords
:
Gene Expression Regulation
,
Risk Factors
[+]
Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators
Jan 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Psychoneuroendocrinology. 2014 Feb ;40:96-107. Epub 2013 Nov 15. PMID:
24485481
Article Published Date
: Jan 31, 2014
Study Type
: Human Study
Additional Links
Diseases
:
Inflammation
Therapeutic Actions
:
Meditation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Histone deacetylase inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Spa therapy induces clinical improvement and protein changes in patients with chronic back pain.
Oct 23, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Reumatismo. 2019 Oct 24 ;71(3):119-131. Epub 2019 Oct 24. PMID:
31649376
Article Published Date
: Oct 23, 2019
Study Type
: Human Study
Additional Links
Diseases
:
Back Pain
,
Osteoarthritis
Therapeutic Actions
:
Spa Bathing
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-23 Downregulation
Additional Keywords
:
Gene Expression Regulation
[+]
Sudarshan Kriya practice may exert effects on immunity, aging, cell death, and stress regulation through transcriptional regulation.
Jan 31, 2008
Click here to read the entire abstract
Pubmed Data
: J Psychosom Res. 2008 Feb ;64(2):213-8. PMID:
18222135
Article Published Date
: Jan 31, 2008
Study Type
: Human Study
Additional Links
Diseases
:
Aging
,
DNA damage
,
Oxidative Stress
Therapeutic Actions
:
Yogic Technique: Sudarshan kriya
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Additional Keywords
:
Gene Expression Regulation
[+]
Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Respir Res. 2015 ;16:106. Epub 2015 Sep 15. PMID:
26369337
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Broccoli Sprouts
,
Sulforaphane
Diseases
:
Asthma
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche.
Dec 22, 2015
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2015 Dec 23. Epub 2015 Dec 23. PMID:
26701664
Article Published Date
: Dec 22, 2015
Study Type
: Human Study
Additional Links
Substances
:
Black Raspberry
Diseases
:
Oral Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Gene Expression Regulation
[+]
Taking myo-inositol by women with PCOS had beneficial effects on glycemic control, triglycerides and VLDL-cholesterol levels, and gene expression of PPAR-γ.
Jan 03, 2019
Click here to read the entire abstract
Pubmed Data
: Gynecol Endocrinol. 2019 Jan 4:1-6. Epub 2019 Jan 4. PMID:
30608001
Article Published Date
: Jan 03, 2019
Study Type
: Human Study
Additional Links
Substances
:
Myo-inositol
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Gene Expression Regulation
,
Superiority of Natural Substances versus Drugs
[+]
The bioactivity of garlic is multifaceted and includes activation of genes related to immunity, apoptosis, and xenobiotic metabolism in humans and Mono Mac 6 cells.
Sep 29, 2015
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2015 Sep 30. Epub 2015 Sep 30. PMID:
26423732
Article Published Date
: Sep 29, 2015
Study Type
: Human Study
Additional Links
Substances
:
Garlic
Diseases
:
Leukemia: Monocytic
Pharmacological Actions
:
Apoptotic
,
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Diabetol Metab Syndr. 2019 ;11:111. Epub 2019 Dec 19. PMID:
31890045
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Genistein
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Gene Expression Regulation
[+]
The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Cancer. 2013 ;65(2):240-6. PMID:
23441611
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, Human Study
Additional Links
Substances
:
Water: Deuterium Depleted
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Carcinoma: Small Cell Lung
,
Lung Cancer
,
Lung Cancer: Metastatic
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
Additional Keywords
:
Gene Expression Regulation
,
Proto-oncogene
[+]
Third-trimester high-dose vitD3 supplementation in healthy pregnant women had balanced effects on biomarkers of cord blood Th1 and Th2 responses.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr J. 2016 ;15(1):75. Epub 2016 Aug 9. PMID:
27506771
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Vitamin D
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
Transcriptomic profile of whole blood cells from elderly subjects fed probiotic bacteria Lactobacillus rhamnosus GG.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(2):e0147426. Epub 2016 Feb 9. PMID:
26859761
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Lactobacillus rhamnosus GG
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory CXCL2 gene in humans.
Sep 30, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Res Notes. 2012 Oct 1 ;5:540. Epub 2012 Oct 1. PMID:
23021568
Article Published Date
: Sep 30, 2012
Study Type
: Human Study
Additional Links
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Upregulation of vitamin D-related genes in schizophrenic patients.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neuropsychiatr Dis Treat. 2018 ;14:2583-2591. Epub 2018 Oct 9. PMID:
30349256
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Vitamin D
Diseases
:
Schizophrenia
,
Vitamin D Deficiency
Additional Keywords
:
Gene Expression Regulation
[+]
Vitamin C supplementation has beneficial effects for the male partners of couples with recurrent pregnancy loss could lead to improved pregnancy outcomes.
Feb 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Exp Reprod Med. 2020 Mar ;47(1):68-76. Epub 2020 Mar 1. PMID:
32146776
Article Published Date
: Feb 29, 2020
Study Type
: Human Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Miscarriage: Recurrent
Pharmacological Actions
:
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Vitamin D supplementation may have a beneficial role in ulcerative colitis patients.
Jun 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Gastroenterol. 2016 Jul-Aug;22(4):316-23. PMID:
27488327
Article Published Date
: Jun 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
Vitamin D
Diseases
:
C-Reactive Protein
,
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Anti-Inflammatory Agents
,
C-Reactive Protein
,
Gene Expression Regulation
,
Ulcerative Colitis
,
VITAMIN D
[+]
Yogic practices have rapid effects at the molecular level in circulating immune cells.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(4):e61910. Epub 2013 Apr 17. PMID:
23613970
Article Published Date
: Dec 31, 2012
Study Type
: Human In Vitro, Human Study
Additional Links
Therapeutic Actions
:
Yoga
,
Yogic Technique: Sudarshan kriya
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
Alpha-lipoic acid could be a therapeutic agent because of its inhibitory effects on ROS production, inflammation, and adipose tissue expansion
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Medicine (Baltimore). 2016 Jan ;95(2):e2497. PMID:
26765462
Article Published Date
: Dec 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Graves Disease
,
Oxidative Stress
Pharmacological Actions
:
Anti-Adipogenic
,
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Gene Expression Regulation
[+]
Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.
Jul 31, 2012
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2012 Aug 1 ;84(3):402-10. Epub 2012 Mar 29. PMID:
22483777
Article Published Date
: Jul 31, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Amurensin G
Diseases
:
Cancers: Drug Resistant
,
Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions
:
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Cancer Stem Cells
,
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Amurensin G had significant antiangiogenic and antitumor growth effects in tamoxifen resistant breast cancer.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2012 Oct ;50(10):3625-34. Epub 2012 Jul 27. PMID:
22842120
Article Published Date
: Sep 30, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Amurensin G
Diseases
:
Breast Cancer
,
Breast Cancer: Drug Resistant
Pharmacological Actions
:
Anti-Angiogenic
,
Anti-Tumor
,
Antineoplastic Agents
,
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Epigenetic Modification In Cancer
,
Gene Expression Regulation
[+]
Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.
Oct 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Pharmacol. 2010 Nov ;78(5):855-64. Epub 2010 Aug 16. PMID:
20713551
Article Published Date
: Oct 31, 2010
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Amurensin G
Diseases
:
Breast Cancer: Drug Resistant
,
Cancers: Drug Resistant
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Gene Expression Regulation
,
Natural Substance/Drug Synergy
,
Plant Extracts
Problem Substances
:
Doxorubicin
[+]
Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.
May 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Tradit Chin Med. 2014 Jun ;34(3):302-8. PMID:
24992757
Article Published Date
: May 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Enzyme Inhibitors
,
MicroRNA modulator
Additional Keywords
:
Chinese Herbs
,
Gene Expression Regulation
[+]
Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.
Jan 10, 2015
Click here to read the entire abstract
Pubmed Data
: In Vivo. 2015 11-12;29(6):711-728. PMID:
26546528
Article Published Date
: Jan 10, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Lung Cancer
,
Non-Small-Cell Lung Carcinoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Gene Expression Regulation
[+]
In utero bisphenol A exposure is linked with sex specific changes in the transcriptome and methylome of human amniocytes.
Sep 18, 2019
Click here to read the entire abstract
Pubmed Data
: J Clin Endocrinol Metab. 2019 Sep 19. Epub 2019 Sep 19. PMID:
31536135
Article Published Date
: Sep 18, 2019
Study Type
: Human In Vitro
Additional Links
Diseases
:
Bisphenol Toxicity
Additional Keywords
:
Gene Expression Regulation
Problem Substances
:
Bisphenol A
[+]
LED irradiation promoted elastin gene expression more in elderly than in younger adults.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 1):161-7. PMID:
27469564
Article Published Date
: Mar 31, 2016
Study Type
: Human In Vitro
Additional Links
Diseases
:
Periodontal Diseases
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Additional Keywords
:
Gene Expression Regulation
[+]
Malaysian and Brazilian red propolis show potential to assist in wound healing.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2015 ;15:294. Epub 2015 Aug 25. PMID:
26303848
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Propolis: Bee
,
Propolis: Brazillian
Diseases
:
Wound Healing
Additional Keywords
:
Dose Response
,
Gene Expression Regulation
[+]
Psoralea corylifolia induces apoptosis and autophagy and alteres genes expression assayed by cDNA microarray in human prostate cancer PC-3 cells.
Jun 30, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2018 Jul ;33(7):770-788. Epub 2018 Apr 18. PMID:
29667321
Article Published Date
: Jun 30, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Babchi
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Autophagy Up-regulation
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 Nov-Dec;68(8):1338-1348. Epub 2016 Aug 16. PMID:
27636860
Article Published Date
: Oct 31, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Colon Cancer
Pharmacological Actions
:
Cytoprotective
,
Nrf2 activation
Additional Keywords
:
Gene Expression Regulation
,
Selective Cytotoxicity
[+]
Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes.
Oct 24, 2017
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 2017 Oct 25. Epub 2017 Oct 25. PMID:
29078374
Article Published Date
: Oct 24, 2017
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Taurine
Diseases
:
Chronic Obstructive Pulmonary Disease
Additional Keywords
:
Gene Expression Regulation
[+]
The proapoptotic effect of cannabinoids on tumor cells is mediated by a ceramide dependent upregulation of the stress protein p8.
Mar 31, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell. 2006 Apr ;9(4):301-12. PMID:
16616335
Article Published Date
: Mar 31, 2006
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Cannabinoids
Diseases
:
Astrocytoma
,
Cancers: All
,
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Altered Protein Expression
,
Gene Expression Regulation
[+]
These results provide important new data for ellagic acid in anti-colorectal carcinoma research.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2017 Feb ;50(2):613-621. Epub 2017 Jan 5. PMID:
28101576
Article Published Date
: Jan 31, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Gene Expression Regulation
[+]
Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:2528935. Epub 2015 Dec 28. PMID:
26823946
Article Published Date
: Dec 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Hydrogen Peroxide Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Genom Data. 2015 Sep 1 ;5:189-191. PMID:
26309812
Article Published Date
: Aug 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Mushrooms: All
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Epigenetic Modification In Cancer
,
Gene Expression Regulation
[+]
Vitamin C modulated the immune system.
Mar 22, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Genomics. 2017 Mar 23 ;18(1):252. Epub 2017 Mar 23. PMID:
28335738
Article Published Date
: Mar 22, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Vitamin C
Diseases
:
Tuberculosis
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
10% pectin supplementation for one month in adult rats decreases body-fat content and ameliorates age-related insulin and leptin resistance.
Jul 21, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 Jul 22. Epub 2015 Jul 22. PMID:
26201873
Article Published Date
: Jul 21, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Pectin
Diseases
:
Insulin Resistance
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
,
Supplementation
[+]
5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID:
27468227
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
,
Wnt/β-catenin signaling pathway modulation
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Gene Expression Regulation
[+]
A cucurbitane type triterpenoid compound from Momordica charantia alleviated diabetic metabolic symptoms in alloxan induced diabetic mice.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Nov ;14(5):4865-4872. Epub 2016 Oct 5. PMID:
27748816
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Bitter Melon
Diseases
:
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Gene Expression Regulation
[+]
A hot water extract from wasabi leaves induces mild suppression of obesity in a high-fat diet induced mice.
Jul 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Res Pract. 2013 Aug ;7(4):267-72. Epub 2013 Aug 7. PMID:
23964313
Article Published Date
: Jul 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Wasabi
Diseases
:
High Fat Diet
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
,
high fat diet
,
obesity
,
Wasabi
[+]
A Polysaccharide from black current is effective in preventing and alleviating the development of atopic dermatitis-like skin disease.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biosci Microbiota Food Health. 2018 ;37(1):19-24. Epub 2017 Nov 16. PMID:
29387518
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Black Currant
Diseases
:
Atopic Dermatitis
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
,
Polysaccharides
[+]
A thymoquinone-rich fraction extracted from Nigella sativa effectively improved the plasma and liver antioxidant capacity.
Feb 28, 2010
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2010 Mar 1 ;48(5):664-72. Epub 2009 Dec 11. PMID:
20005291
Article Published Date
: Feb 28, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Antioxidants
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Gene Expression Regulation
[+]
A. brasiliensis improves the serum lipid profile in hypercholesterolemic rats
May 04, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2016 May 5. Epub 2016 May 5. PMID:
27151383
Article Published Date
: May 04, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Agaricus brasiliensis
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Achillea Millefolium hydro alcoholic extract protects pancreatic cells.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Cell Med. 2014 ;3(4):255-62. PMID:
25635252
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Yarrow
Diseases
:
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Interleukin-1 beta downregulation
,
Pancreato Protective Agents
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Additive effect of walnut and chokeberry on regulation of antioxidant enzyme gene expression and attenuation of lipid peroxidation.
Oct 03, 2018
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2018 Oct 4. Epub 2018 Oct 4. PMID:
30446253
Article Published Date
: Oct 03, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Chokeberry
,
Walnut
Diseases
:
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Administering ubiquinol 30 min before traumatic brain injury significantly affected cerebral gene expression profiles.
Jun 30, 2017
Click here to read the entire abstract
Pubmed Data
: Nurs Outlook. 2017 Jul 1. Epub 2017 Jul 1. PMID:
28755974
Article Published Date
: Jun 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ubiquinol
Diseases
:
Brain Injury: Traumatic
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Administration of Moringa oleifera extract mitigated cyclophosphamide-induced testicular damage.
May 14, 2020
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2020 May 15:112922. Epub 2020 May 15. PMID:
32422360
Article Published Date
: May 14, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Chemoprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Alliin alters gut microbiota and gene expression of colonic epithelial tissues.
Mar 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2019 Apr ;43(4):e12795. Epub 2019 Feb 21. PMID:
31353605
Article Published Date
: Mar 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Allicin
Diseases
:
Bacterial Infections
Pharmacological Actions
:
Antimicrobial
,
Gastrointestinal Agents
,
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
,
Microbiota
[+]
Allium hookeri root extract inhibits adipogenesis by promoting lipolysis in high fat diet-induced obese mice.
Sep 19, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 Sep 20 ;11(10). Epub 2019 Sep 20. PMID:
31547031
Article Published Date
: Sep 19, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Onion
Diseases
:
High Fat Diet
,
Obesity
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
,
Phytotherapy
,
Plant Extracts
[+]
Alpha-lipoic acid can alleviate acute inflammatory response in animals.
Aug 15, 2016
Click here to read the entire abstract
Pubmed Data
: Lipids. 2016 Aug 16. Epub 2016 Aug 16. PMID:
27531126
Article Published Date
: Aug 15, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Alternating consumption of β-glucan and quercetin reduces mortality in mice with colorectal cancer.
Sep 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Sci Nutr. 2019 Oct ;7(10):3273-3285. Epub 2019 Sep 4. PMID:
31660141
Article Published Date
: Sep 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Beta-glucan
,
Quercetin
Diseases
:
Cancer Mortality
,
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemotherapeutic
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biomed Sci. 2015 ;22(1):28. Epub 2015 Apr 17. PMID:
25898131
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Polyphenols
,
Seaweed
Diseases
:
Cancers: Drug Resistant
,
Cancers: Radiation-Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Autophagy Inhibitors
,
Chemotherapeutic
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
,
Gene Expression Regulation
,
Significant Treatment Outcome
[+]
An extract of Bacopa monniera effectively protects the kidney from hypercholesterolemia-mediated oxido-lipidemic damage.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: Pharm Biol. 2014 Oct ;52(10):1327-34. Epub 2014 Jul 28. PMID:
25068673
Article Published Date
: Sep 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Bacopa
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Antioxidant Effects
,
Renoprotective
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
An extract of Bacopa monnieri restored the memory in CoCl2-hypoxia mimetic mice.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2015 ;2015:347978. Epub 2015 Aug 27. PMID:
26413121
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Bacopa
Diseases
:
Brain Hypoxia
,
Cognitive Decline/Dysfunction
,
Memory Disorders
,
Memory Loss
Pharmacological Actions
:
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
An extract of black ginseng ameliorated hypercholesterolemia in rats fed a high-cholesterol diet.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ginseng Res. 2016 Apr ;40(2):160-8. Epub 2015 Jul 18. PMID:
27158237
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Cardioprotective
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Angelica sinensis suppresses body weight gain and alters expression of the FTO Gene in high-fat-diet induced obesity.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2017 ;2017:6280972. Epub 2017 Sep 20. PMID:
29098158
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Angelica
Diseases
:
High Fat Diet
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Annatto extract and β-carotene enhances antioxidant status and regulate gene expression in neutrophils of diabetic rats.
Feb 29, 2012
Click here to read the entire abstract
Pubmed Data
: Free Radic Res. 2012 Mar ;46(3):329-38. Epub 2012 Feb 6. PMID:
22239725
Article Published Date
: Feb 29, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Achiote
,
beta-Carotene
Diseases
:
Diabetes Mellitus: Type 2
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Catalase Up-Regulation
,
MicroRNA modulator
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Anti-aging effects of Korean red ginseng.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ginseng Res. 2021 Jan ;45(1):183-190. Epub 2020 Sep 16. PMID:
33437170
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (Korean)
Diseases
:
Aging
Additional Keywords
:
Gene Expression Regulation
[+]
Apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomol Ther (Seoul). 2016 Mar 1 ;24(2):163-70. PMID:
26902085
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apigenin
Pharmacological Actions
:
Chondroprotective
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Application of aloe vera gel will increase TGF-β gene expression, ultimately accelerating the wound healing process.
Jul 13, 2016
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2016 Jul 14:1-6. Epub 2016 Jul 14. PMID:
27660884
Article Published Date
: Jul 13, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Aloe Vera
Diseases
:
Wound Healing
Pharmacological Actions
:
Transforming growth factor beta (TGF-β) upregulation
Additional Keywords
:
Gene Expression Regulation
[+]
Aqueous extract of burdock root reduced body weight and cholesterol in rats, possibly by modulating the differential expression of genes.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Int Med Res. 2017 Jan 1:300060517716341. Epub 2017 Jan 1. PMID:
28758851
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Burdock
Diseases
:
High Fat Diet
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Astaxanthin and vitamin E effectively improved hepatic gene expression.
Mar 07, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Mol Sci. 2017 Mar 8 ;18(3). Epub 2017 Mar 8. PMID:
28282876
Article Published Date
: Mar 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
,
Vitamin E
Diseases
:
High Fat Diet
,
Liver Fibrosis
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Fibrotic
,
Hepatoprotective
,
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice.
Jan 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Feb ;28:9-18. Epub 2015 Sep 30. PMID:
26878778
Article Published Date
: Jan 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
High Fat Diet
,
Triglycerides: Elevated
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Astaxantin supplementation was found to regulate housekeeping genes in mice.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Genom Data. 2016 Mar ;7:32-7. Epub 2015 Nov 7. PMID:
26981356
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
,
Supplementation
[+]
Baccharis trimera improves the antioxidant defense system and inhibits iNOS and NADPH oxidase expression in a rat model of inflammation.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Biotechnol. 2013 ;14(11):975-84. PMID:
24372242
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Baccharis trimera
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Inflammation
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Baccharis trimera may be a promising pharmacological treatment for alcoholic liver disease.
Dec 24, 2016
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2016 Dec 25 ;260:22-32. Epub 2016 Oct 15. PMID:
27756550
Article Published Date
: Dec 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Baccharis trimera
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Bacopa monnieri extracts have memory enhancing and anti-diabetic properties.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(7):e0131862. Epub 2015 Jul 10. PMID:
26161865
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Bacopa
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
,
Diabetes Mellitus: Type 2
,
Memory Loss
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Bee venom may be a useful therapeutic agent for the prevention of fibrosis that characterizes progression of chronic kidney disease.
May 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Toxins (Basel). 2015 Jun ;7(6):1917-28. Epub 2015 May 29. PMID:
26035488
Article Published Date
: May 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Bee Venom
Diseases
:
Chronic Kidney Disease (CKD)
,
Kidney Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Renoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(8):e0134172. Epub 2015 Aug 7. PMID:
26252777
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Metabolic Diseases
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Berberine nanoencapsulation attenuates hallmarks of scoplomine induced Alzheimer's-like disease.
Jun 27, 2020
Click here to read the entire abstract
Pubmed Data
: Curr Clin Pharmacol. 2020 Jun 28. Epub 2020 Jun 28. PMID:
32598269
Article Published Date
: Jun 27, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Black elderberry may have the potential to influence HDL dysfunction associated with chronic inflammation by impacting hepatic gene expression.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 Apr ;6(4):1278-87. PMID:
25758596
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Elderberry
Diseases
:
Atherosclerosis
,
Hyperlipidemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypoglycemic Agents
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Black rice extract is a potentially useful ingredient to protect against age related osteoporosis and diet induced obesity.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 Jan ;6(1):265-75. Epub 2014 Nov 27. PMID:
25428526
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Rice: Black
Diseases
:
Obesity
,
Osteoarthritis
Pharmacological Actions
:
Osteogenic
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Both curcumin and carvacrol showed a great efficacy against hepatocellular carcinoma.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2015 ;16(12):4949-54. PMID:
26163620
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Carvacrol
,
Curcumin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Gene Expression Regulation
[+]
Broccoli sprout extract protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.
Sep 20, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID:
26401074
Article Published Date
: Sep 20, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Broccoli Sprouts
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
,
Phase I Detoxification Enzyme Inducer
,
Phase II Detoxification Enzyme Inducer
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
Problem Substances
:
Acetaminophen
[+]
C. spinosa has the potential to down regulate inflammation-involved genes in Alzheimer's disease.
Oct 24, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Neurosci. 2016 Oct 25:1-8. Epub 2016 Aug 25. PMID:
27778760
Article Published Date
: Oct 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Capparis spinosa (caper)
,
Flavonoids
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Caffeic acid phenethyl ester increased NDRG1 expression through phosphorylation of ERK1/2 to repress oral squamous cell carcinoma cells growth.
Feb 08, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2017 Feb 9. Epub 2017 Feb 9. PMID:
28181403
Article Published Date
: Feb 08, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Caffeic acid phenethyl ester
Diseases
:
Oral Cancer
Pharmacological Actions
:
Antiproliferative
Additional Keywords
:
Gene Expression Regulation
[+]
CBD alleviates behavioural and gene expression alterations suggesting its potential for the management of cocaine withdrawal.
Nov 22, 2020
Click here to read the entire abstract
Pubmed Data
: Neurotherapeutics. 2020 Nov 23. Epub 2020 Nov 23. PMID:
33230690
Article Published Date
: Nov 22, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cocaine Withdrawal
Additional Keywords
:
Gene Expression Regulation
[+]
Celastrol suppresses experimental autoimmune encephalomyelitis.
Mar 31, 2019
Click here to read the entire abstract
Pubmed Data
: Inflamm Res. 2019 Apr ;68(4):285-296. Epub 2019 Feb 28. PMID:
30820608
Article Published Date
: Mar 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Celastrol
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Brain-derived neurotrophic factor modulator
,
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation.
Jan 18, 2018
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2018 Jan 19. Epub 2018 Jan 19. PMID:
29361151
Article Published Date
: Jan 18, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Black Raspberry
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Gene Expression Regulation
[+]
Chrysanthemum indicum L. ethanol extract reduces high-fat diet-induced obesity in mice.
May 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Jun ;15(6):5070-5076. Epub 2018 Apr 10. PMID:
29844801
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Chrysanthemum Indicum
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats.
Jan 12, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Jan 13 ;88:52-60. Epub 2017 Jan 13. PMID:
28092845
Article Published Date
: Jan 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cinnamaldehyde
Diseases
:
Gestational Diabetes
Pharmacological Actions
:
Adiponectin Down-Regulation
,
Anticholesteremic Agents
,
Hypoglycemic Agents
,
Insulin Sensitizers
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.
Jun 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2014 Jul ;8(1):260-266. Epub 2014 May 16. PMID:
24944632
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
High Fat Diet
,
Hyperlipidemia
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Coffee modulates the transcription of genes related to prostate cancer and inflammation.
Sep 02, 2015
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2015 Sep 3. Epub 2015 Sep 3. PMID:
26419686
Article Published Date
: Sep 02, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Coffee
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Combination of apple peel and blueberry extracts synergistically induced lifespan extension via DAF-16 in Caenorhabditis elegans.
Jul 21, 2020
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2020 Jul 22 ;11(7):6170-6185. PMID:
32578648
Article Published Date
: Jul 21, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Apple
,
Blueberry
Diseases
:
Aging
Additional Keywords
:
Gene Expression Regulation
[+]
Consumption of cocoa powder by pigs can contribute to gut health by enhancing the abundance of Lactobacillus and Bifidobacterium species.
Mar 01, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2016 Mar 2. Epub 2016 Mar 2. PMID:
26936136
Article Published Date
: Mar 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cocoa
Diseases
:
Dysbiosis: Bifidobacteria Deficiency
Additional Keywords
:
Gene Expression Regulation
,
Microbiome
[+]
Consumption of lingonberries, and also blackcurrants and bilberries, modulates the liver response to hight fat diet.
Sep 01, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr Biochem. 2015 Sep 2. Epub 2015 Sep 2. PMID:
26423886
Article Published Date
: Sep 01, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Acai
,
Bilberry
,
Black Currant
,
Lingonberry
Diseases
:
High Fat Diet
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Nov ;37:60-66. Epub 2016 Aug 4. PMID:
27619543
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cranberry
Diseases
:
High Fat Diet
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
MicroRNA modulator
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Curcumin administration improved insulin sensitivity and reduced hepatic gluconeogenic gene expression.
Sep 01, 2015
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2015 Sep 2. Epub 2015 Sep 2. PMID:
26338887
Article Published Date
: Sep 01, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Insulin Sensitizers
Additional Keywords
:
Gene Expression Regulation
[+]
Curcumin and its analogue induce apoptosis in leukemia cells and have additive effects with bortezomib.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2015 ;2015:968981. Epub 2015 May 17. PMID:
26075279
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Curcumin could be a potential leading compound for development of drugs for the prevention of obesity and insulin resistance.
May 17, 2016
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2016 May 18. Epub 2016 May 18. PMID:
27208389
Article Published Date
: May 17, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
High Fat Diet
,
Insulin Resistance
,
Obesity
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Curcumin effectively attenuates brain edema in mice with ICH through inhibition of the NF-κB pathway and subsequently the expression of AQP4 and AQP9.
Jun 28, 2015
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2015 Jun 29. Epub 2015 Jun 29. PMID:
26119880
Article Published Date
: Jun 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Brain Edema
,
Intracerebral Hemorrhage
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
,
Gene Expression Regulation
[+]
Curcumin improved pancreatic glucose sensing, insulin gene expression, and insulin secretion.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2015 Sep ;35(9):823-33. Epub 2015 Jul 2. PMID:
26255758
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Prediabetes
Additional Keywords
:
Gene Expression Regulation
[+]
Curcumin protects against intestinal origin endotoxemia in rat liver cirrhosis.
Feb 13, 2017
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2017 Feb 14. Epub 2017 Feb 14. PMID:
28196290
Article Published Date
: Feb 13, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Chemically-Induced Liver Damage
,
Liver Cirrhosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Curcumin was shown to have positive effects on lifespan extension in animal studies.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2013 Jan-Feb;39(1):133-40. Epub 2013 Jan 17. PMID:
23325575
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, Insect Study
Additional Links
Substances
:
Curcumin
,
Tetrahydrocurcumin
Diseases
:
Aging
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Gene Expression Regulation
,
Longevity
[+]
Deep sea water drinking benefits the attenuation of high fat diet-induced cardiovascular disorders in hamsters.
Jul 31, 2011
Click here to read the entire abstract
Pubmed Data
: Food Chem. 2011 Aug 1 ;127(3):1146-52. Epub 2011 Feb 23. PMID:
25214107
Article Published Date
: Jul 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Water: Deep Sea
Diseases
:
High Fat Diet
,
Lipid Peroxidation
Pharmacological Actions
:
Cardioprotective
,
Malondialdehyde Down-regulation
Additional Keywords
:
Gene Expression Regulation
[+]
Delta-tetrahydrocannabinol (THC) may modulate immune response through epigenetic regulation involving histone modifications.
Jul 03, 2014
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2014 Jul 4 ;289(27):18707-18718. Epub 2014 May 19. PMID:
24841204
Article Published Date
: Jul 03, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Delta-tetrahydrocannabinol (THC)
Diseases
:
Autoimmune Diseases
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Epigenetic Modification
,
Gene Expression Regulation
,
Histone Modifications
[+]
Dietary betaine increases Fgf21 levels to improve metabolic health in mice.
Feb 07, 2016
Click here to read the entire abstract
Pubmed Data
: Diabetes. 2016 Feb 8. Epub 2016 Feb 8. PMID:
26858359
Article Published Date
: Feb 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Betaine
Diseases
:
Diabetes Mellitus: Type 2
,
Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions
:
Fibroblast growth factor 21 upregulation
Additional Keywords
:
Gene Expression Regulation
,
Risk Reduction
[+]
dietary chlorophyllin and ellagic acid that can reverse gene expression signature associated with carcinogenesis.
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2012 ;7(4):e34628. Epub 2012 Apr 2. PMID:
22485181
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Chlorophyllin
,
Ellagic Acid
Diseases
:
Oral Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Dietary dandelion extracts promoted intestine health by improving intestine morphology, immunity, antioxidant abilities and intestinal barrier.
Dec 15, 2017
Click here to read the entire abstract
Pubmed Data
: Fish Shellfish Immunol. 2017 Dec 16 ;73:197-206. Epub 2017 Dec 16. PMID:
29258755
Article Published Date
: Dec 15, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Dandelion
Pharmacological Actions
:
Antioxidants
,
Gastrointestinal Agents
,
Immunomodulatory
Additional Keywords
:
Antioxidants
,
Dandelion
,
Gastrointestinal Agents
,
Gene Expression Regulation
,
Immunomodulatory
[+]
Dietary royal jelly ameliorates diet-induced obesity, hyperglycemia, and hepatic steatosis by promoting metabolic thermogenesis in BAT in mice.
Jan 10, 2017
Click here to read the entire abstract
Pubmed Data
: Obes Res Clin Pract. 2017 Jan 11. Epub 2017 Jan 11. PMID:
28089395
Article Published Date
: Jan 10, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Royal Jelly
Diseases
:
Hepatic Steatosis
,
Hyperglycemia
,
Metabolic Diseases
,
Obesity
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Dietary selenium protected chicks from aflatoxin B1-induced liver injury.
Mar 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2016 Mar 9. Epub 2016 Mar 9. PMID:
26962192
Article Published Date
: Mar 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Selenium
Diseases
:
Liver Damage: Aflatoxin-Induced
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Dietary supplementation with dried plum may prevent the skeletal effects of radiation exposures either in space or on Earth.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:21343. Epub 2016 Feb 11. PMID:
26867002
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Plum
Pharmacological Actions
:
Radioprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
Anti Therapeutic Actions
:
Low Dose Ionizing Radiation
[+]
Dietary tomato components reduced testosterone regulated genes associated with early prostate carcinogenesis.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2014 Dec ;7(12):1228-39. Epub 2014 Oct 14. PMID:
25315431
Article Published Date
: Nov 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Lycopene
,
Tomato
Diseases
:
Prostate Cancer
,
Prostate Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Cancer Stem Cells
,
Gene Expression Regulation
[+]
Dietary XN suppressed SREBP-1 target gene expression in the liver accompanied by a reduction of the mature form of hepatic SREBP-1, inhibiting the development of obesity and hepatic steatosis.
Jul 02, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biol Chem. 2015 Jul 3. Epub 2015 Jul 3. PMID:
26140926
Article Published Date
: Jul 02, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Xanthohumol
Diseases
:
Hepatic Steatosis
,
Metabolic Diseases
,
Obesity
Pharmacological Actions
:
Hepatoprotective
,
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
EGCG has significant antipathogenic effects on C. difficile.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2015 Dec ;80(12):M2925-31. Epub 2015 Nov 10. PMID:
26556797
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Clostridium Infections
Pharmacological Actions
:
Antimicrobial
,
Gastroprotective
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG induces miRNA profile changes in the NNK-induced A/J mouse lung tumor.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Genomics. 2014 ;15 Suppl 11:S3. Epub 2014 Dec 16. PMID:
25559244
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
MicroRNA modulator
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG may ameliorate diet-induced metabolic misalignment by regulating the rhythmic expression of the circadian clock genes in the liver and fat.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta. 2017 Jun ;1863(6):1575-1589. Epub 2017 Apr 12. PMID:
28412321
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Metabolic Syndrome X
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Circadian Clock Proteins
,
Gene Expression Regulation
[+]
EGCG may be a useful adjuvant therapeutic agent for the treatment of breast cancer.
Apr 12, 2017
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2017 Apr 13 ;69(5):924-928. Epub 2017 Apr 13. PMID:
28646740
Article Published Date
: Apr 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Chemotherapeutic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substances Versus Drugs
[+]
EGCG might represent a new potential therapeutic or preventive approach to control white spot syndrome.
Jun 21, 2017
Click here to read the entire abstract
Pubmed Data
: Fish Shellfish Immunol. 2017 Jun 22. Epub 2017 Jun 22. PMID:
28648884
Article Published Date
: Jun 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Fish Diseases
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG modulates the reversal of gene silencing involved in colon carcinogenesis.
May 05, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 May 6. Epub 2016 May 6. PMID:
27167203
Article Published Date
: May 05, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Dose Response
,
Epigenetic Modification In Cancer
,
Gene Expression Regulation
[+]
EGCG supplement specifically counteracts daytime overeating induced by high fat diet in mice.
Jul 27, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 Jul 28. Epub 2016 Jul 28. PMID:
27468160
Article Published Date
: Jul 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
Pharmacological Actions
:
Appetite Depressants
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG-containing supplements may be important in correcting skeletal deficits associated with Down syndrome.
Jan 08, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 Jan 9. Epub 2016 Jan 9. PMID:
26748562
Article Published Date
: Jan 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Additional Keywords
:
Gene Expression Regulation
[+]
Epigallocatechin-3-gallate ameliorates atherosclerosis and modulates hepatic lipid metabolic gene expression.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:195. Epub 2018 Mar 9. PMID:
29593532
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Ethanolic extract of Salvia hispanica L. regulates blood pressure.
Aug 25, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 Aug 26 ;25(17). Epub 2020 Aug 26. PMID:
32858788
Article Published Date
: Aug 25, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Chia
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Exercise modulates the levels of growth inhibitor genes before and after multiple sclerosis.
Jan 29, 2020
Click here to read the entire abstract
Pubmed Data
: J Neuroimmunol. 2020 Jan 30 ;341:577172. Epub 2020 Jan 30. PMID:
32028123
Article Published Date
: Jan 29, 2020
Study Type
: Animal Study
Additional Links
Diseases
:
Multiple Sclerosis
Therapeutic Actions
:
Exercise
Additional Keywords
:
Gene Expression Regulation
[+]
Exercise-induced changes of gene expression in the cerebellum of aged mice.
Jan 21, 2020
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2020 Jan 22 ;521(4):952-956. Epub 2019 Nov 11. PMID:
31718796
Article Published Date
: Jan 21, 2020
Study Type
: Animal Study
Additional Links
Diseases
:
Aging
,
Cognitive Decline/Dysfunction
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
,
Risk Reduction
[+]
Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injury
Jun 30, 2019
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2019 Jul ;129:365-375. Epub 2019 May 3. PMID:
31054998
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Ferulic acid
Diseases
:
Psoriasis
Pharmacological Actions
:
Interleukin-17 downregulation
Additional Keywords
:
Gene Expression Regulation
[+]
Fish oil and krill oil supplementation decreases fasting blood glucose and improves glucose tolerance in obese New Zealand white rabbits.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2015 Oct ;54(7):1055-67. Epub 2014 Oct 15. PMID:
25315197
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Fish Oil
,
Krill
Diseases
:
Obesity
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Folic acid supplementation delays atherosclerotic lesion development.
May 04, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 May 5 ;18(5). Epub 2017 May 5. PMID:
28475147
Article Published Date
: May 04, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Folic Acid
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
Additional Keywords
:
Gene Expression Regulation
[+]
Freeze-dried strawberry-blueberry powder might be useful for treatment or prevention of obesity-related diseases.
Oct 11, 2017
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2017 Oct 12. Epub 2017 Oct 12. PMID:
29022978
Article Published Date
: Oct 11, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Blueberry
,
Strawberry
Diseases
:
Insulin Resistance
,
Obesity
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Fresh rice bran protein regulates cholesterol metabolism in mice fed the high fat and cholesterol diet.
May 23, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 May 24. Epub 2016 May 24. PMID:
27216972
Article Published Date
: May 23, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Rice Bran
Diseases
:
High Fat Diet
,
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Fruit juice improves the antioxidant capacity and prevents the oxidative damage in liver, brain and colon.
Mar 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Genet Mol Biol. 2017 Mar 20:0. Epub 2017 Mar 20. PMID:
28323302
Article Published Date
: Mar 19, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Fruit: All
,
Vegetables: All
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
Additional Keywords
:
Gene Expression Regulation
[+]
Fucoidan lowers lipids by enhancing reverse cholesterol transport-related genes expression.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2019 Aug 1 ;134:759-769. Epub 2019 May 14. PMID:
31100394
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Fucoidan may be beneficial against hyperlipidemia and atherosclerosis.
Mar 21, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Pharmacol Sci. 2016 Mar 22. Epub 2016 Mar 22. PMID:
27094367
Article Published Date
: Mar 21, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Atherosclerosis
,
Hyperlipidemia
Pharmacological Actions
:
Cardioprotective
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Ganoderma lucidum and San-Miao-San supplements could be used in the treatment of systemic lupus erythematosus.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Chin Med. 2016 ;11:23. Epub 2016 Apr 29. PMID:
27134645
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Reishi Mushroom
Diseases
:
Systemic Lupus Erythematosus
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
Ganoderma lucidum of Mexican origin represent a new source of bioactive compounds showing hypocholesterolemic properties and prebiotic effects.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(7):e0159631. Epub 2016 Aug 20. PMID:
27438015
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Prebiotics
,
Reishi Mushroom
Diseases
:
High Fat Diet
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substances Versus Drugs
,
Superiority of Natural Substances versus Drugs
[+]
Genes induced by Panax notoginseng in a rodent model of ischemia-reperfusion injury.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Immunol Res. 2020 ;2020:8873261. Epub 2020 Nov 25. PMID:
33294469
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Panax Notoginseng
Diseases
:
Stroke
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Genistein intake mimicking Asian consumption patterns improved response of mammary tumors to tamoxifen therapy.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2017 Feb 1 ;23(3):814-824. PMID:
28148690
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Genistein
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemotherapeutic
,
Immunomodulatory
Additional Keywords
:
Breast Cancer
,
Chemotherapeutic
,
Gene Expression Regulation
,
Genistein
,
Immunomodulatory
[+]
Ginkgo biloba leaves extract elicited marked improvement in the histological feature of liver tissue in HCC groups.
Oct 13, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Biochim Pol. 2016 Oct 14. Epub 2016 Aug 14. PMID:
27741326
Article Published Date
: Oct 13, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Ginseng may be able to prevent obesity, hyperlipidemia, and hepatic steatosis in men with testosterone deficiency.
Aug 23, 2017
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2017 Aug 24 ;210:80-87. Epub 2017 Aug 24. PMID:
28844680
Article Published Date
: Aug 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (Korean)
Diseases
:
Hepatic Steatosis
,
Hyperlipidemia
,
Obesity
,
Testosterone: Too Low
Pharmacological Actions
:
Anti-Adipogenic
,
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity.
Feb 15, 2017
Click here to read the entire abstract
Pubmed Data
: Diabetes. 2017 Feb 16. Epub 2017 Feb 16. PMID:
28209760
Article Published Date
: Feb 15, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Insulin Resistance
,
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Glycyrrhizic acid produces a markedly protective effect against non-alcoholic steatohepatitis.
Aug 03, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Aug 4. Epub 2016 Aug 4. PMID:
27487733
Article Published Date
: Aug 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Licorice
Diseases
:
Liver Steatosis
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Green coffee bean extract has a potential anti-obesity effect with lowering body fat accumulation.
Jun 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Trop Med. 2016 Jul ;9(7):635-43. Epub 2016 May 30. PMID:
27393090
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Green Coffee Bean
Diseases
:
High Fat Diet
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
,
Plant Extracts
[+]
Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis.
Jan 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pathog Dis. 2013 Feb ;67(1):76-83. Epub 2012 Nov 15. PMID:
23620122
Article Published Date
: Jan 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
,
Porphyromonas gingivalis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Heme oxygenase-1 up-regulation
,
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
GTE+Ex function in part by inducing the conversion of WAT to BLAT and provides novel mechanistic insight into this combination.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Funct Foods. 2015 Apr 1 ;14:210-214. PMID:
25844091
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Green Tea
Diseases
:
Metabolic Diseases
Therapeutic Actions
:
Exercise
Additional Keywords
:
Gene Expression Regulation
[+]
Harmine and harmaline are promising candidate to inhibit TCDD-mediated induction of Cyp1a1 in mice hepatic and extrahepatic tissues.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Biomed Res Int. 2013 ;2013:258095. Epub 2012 Dec 20. PMID:
23509697
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Syrian rue
Diseases
:
Liver Cancer
,
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Enzyme Inhibitors
Additional Keywords
:
Gene Expression Regulation
[+]
Hemp seed oil and evening primrose oil has beneficial effects on the repair of myelin.
Jan 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Res Pharm Sci. 2019 Feb ;14(1):36-45. PMID:
30936931
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Evening Primrose Oil
,
Hemp Seed
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
Additional Keywords
:
Gene Expression Regulation
,
Remyelination
[+]
Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biosci Biotechnol Biochem. 2011 ;75(4):774-6. Epub 2011 Apr 22. PMID:
21512236
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Hydrogen Water
Diseases
:
Liver Damage
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Hesperidin attenuated apoptotic-related genes in testicle of a male rat model of varicocoele.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: Andrology. 2020 Jan ;8(1):249-258. Epub 2019 Jul 19. PMID:
31325243
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Hesperidin
Diseases
:
Varicocele
Pharmacological Actions
:
Anti-Apoptotic
Additional Keywords
:
Gene Expression Regulation
[+]
Hyperbaric oxygen therapy exerts an anti-inflammatory effect on DSS-induced colitis in mice.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2016;2016:7141430. Epub 2016 Aug 30. PMID:
27656047
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Diseases
:
Colitis
Therapeutic Actions
:
Hyperbaric Treatment
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Anti-Inflammatory Agents
,
Colitis
,
Gene Expression Regulation
[+]
In utero exposure to germinated brown rice and its GABA extract attenuates high-fat-diet-induced insulin resistance in rat offspring.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutrigenet Nutrigenomics. 2017 ;10(1-2):19-31. Epub 2017 Apr 12. PMID:
28399529
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Brown Rice: Pre-Germinated
Diseases
:
Fetal Origin of Adult Disease
,
High Fat Diet
,
Insulin Resistance
Pharmacological Actions
:
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
,
Risk Reduction
[+]
Inhaled resveratrol treatments could slow ageing-related degenerative changes in mouse lung.
Jan 08, 2017
Click here to read the entire abstract
Pubmed Data
: Thorax. 2017 Jan 9. Epub 2017 Jan 9. PMID:
28070015
Article Published Date
: Jan 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Lung Diseases
Additional Keywords
:
Gene Expression Regulation
[+]
Inhibitory effect of crocin against gastric carcinoma via regulating TPM4 gene.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Onco Targets Ther. 2021 ;14:111-122. Epub 2021 Jan 7. PMID:
33442270
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Crocin
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Gene Expression Regulation
[+]
Intake of lingonberries resulted in decreased triglyceridemia and reduced atherosclerosis in mice.
Feb 17, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 Feb 18. Epub 2016 Feb 18. PMID:
26890232
Article Published Date
: Feb 17, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lingonberry
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
,
Microbiota
[+]
It is suggested that genes playing a key role in the cell cycle regulation and tumour development are sensitive to deuterium depletion.
Apr 30, 2000
Click here to read the entire abstract
Pubmed Data
: In Vivo. 2000 May-Jun;14(3):437-9. PMID:
10904878
Article Published Date
: Apr 30, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Water: Deuterium Depleted
Diseases
:
Cancers: All
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Gene Expression Regulation
,
Proto-oncogene
[+]
Korean red ginseng plays an anti-aging role by modulating expression of aging-related genes and immune cell subsets.
Mar 24, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 Mar 25 ;25(7). Epub 2020 Mar 25. PMID:
32218338
Article Published Date
: Mar 24, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (Korean)
Diseases
:
Aging
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
L. salivarius LI01 and P. pentosaceus LI05 attenuated liver fibrosis by protecting the intestinal barrier and promoting microbiome health.
Jul 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Jul 31 ;7(1):6927. Epub 2017 Jul 31. PMID:
28761060
Article Published Date
: Jul 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus salivarius
,
Probiotics
Diseases
:
Chemically-Induced Liver Damage
,
Liver Cirrhosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastroprotective
,
Hepatoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Lactobacillus plantarum alleviates aflatoxins B1 and M1 induced disturbances in the intestinal genes expression and DNA fragmentation.
Mar 20, 2018
Click here to read the entire abstract
Pubmed Data
: Toxicon. 2018 Mar 21 ;146:13-23. Epub 2018 Mar 21. PMID:
29574215
Article Published Date
: Mar 20, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus plantarum
Diseases
:
DNA damage
Pharmacological Actions
:
Genoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
DNA damage
,
Gene Expression Regulation
,
Genoprotective
,
Lactobacillus plantarum
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Aflatoxin
[+]
Lactobacillus plantarum LMT1-48 exerts anti-obesity effect in high-fat diet-induced obesity model.
Jan 20, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2020 Jan 21 ;10(1):869. Epub 2020 Jan 21. PMID:
31964951
Article Published Date
: Jan 20, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus plantarum
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Lactobacillus plantarum LRCC 5273 isolated from Kimchi ameliorates diet-induced hypercholesterolemia.
Oct 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2018 Nov ;82(11):1964-1972. Epub 2018 Jul 21. PMID:
30032716
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Kimchi
,
Lactobacillus plantarum
Diseases
:
Hypercholesterolemia
Additional Keywords
:
Gene Expression Regulation
[+]
Lactoferrin contributes a renoprotective effect in acute kidney injury and early renal fibrosis.
May 07, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmaceutics. 2020 May 8 ;12(5). Epub 2020 May 8. PMID:
32397266
Article Published Date
: May 07, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Lactoferrin
Diseases
:
Kidney Damage
,
Kidney Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Renoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Litchi pulp could be useful for the prevention and control of alcoholic liver disease.
Jan 24, 2017
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2017 Jan 25 ;8(1):189-200. PMID:
27942667
Article Published Date
: Jan 24, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Litchi
Diseases
:
Alcoholic Liver Disease
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Alcoholic Liver Disease
,
Gene Expression Regulation
,
Hepatoprotective
,
Litchi
[+]
Long-term pantethine treatment counteracts pathologic gene dysregulation and decreases Alzheimer's disease pathogenesis.
Jul 01, 2019
Click here to read the entire abstract
Pubmed Data
: Neurotherapeutics. 2019 Jul 2. Epub 2019 Jul 2. PMID:
31267473
Article Published Date
: Jul 01, 2019
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Pantethine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Longevity-promoting efficacies of rutin in high fat diet fed.
May 19, 2020
Click here to read the entire abstract
Pubmed Data
: Biogerontology. 2020 May 20. Epub 2020 May 20. PMID:
32430858
Article Published Date
: May 19, 2020
Study Type
: Insect Study
Additional Links
Substances
:
Rutin
Diseases
:
High Fat Diet
Additional Keywords
:
Gene Expression Regulation
[+]
Lycopene supplementation attenuates western diet-induced body weight gain.
Jun 30, 2019
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2019 Jul ;69:63-72. Epub 2019 Apr 4. PMID:
31060024
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
Anti Therapeutic Actions
:
Western Diet
[+]
M. pruriens seed pre-treatment had cardio-protective actions against snake venom poisoning.
Aug 31, 2014
Click here to read the entire abstract
Pubmed Data
: Indian J Exp Biol. 2014 Sep ;52(9):849-59. PMID:
25241584
Article Published Date
: Aug 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Mucuna pruriens (aka Velvet Beans)
Diseases
:
Snake Bite: Venom Toxicity
Pharmacological Actions
:
Cardioprotective
,
Prophylactic Agents
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Magnolol is a promising chemopreventive supplement for preventing chemotherapy-induced skeletal muscle atrophy associated with cancer cachexia.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(11):e0143594. Epub 2015 Nov 24. PMID:
26600425
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Magnolia
,
Magnolol
Diseases
:
Bladder Cancer
,
Cachexia: Cancer
,
Cachexia: Chemotherapy Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Mechanisms involved in anti-aging effects of guarana in Caenorhabditis elegans.
Jul 01, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Braz J Med Biol Res. 2018 Jul 2 ;51(9):e7552. Epub 2018 Jul 2. PMID:
29972429
Article Published Date
: Jul 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Guarana
Diseases
:
Aging
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats.
Aug 31, 2005
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2005 Sep ;39(2):129-36. PMID:
16098089
Article Published Date
: Aug 31, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
Problem Substances
:
Aluminum
[+]
Moringa leaves prevent hepatic lipid accumulation and inflammation.
Jun 21, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 Jun 22 ;18(7). Epub 2017 Jun 22. PMID:
28640194
Article Published Date
: Jun 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Mulberry fruit extract pre-treatment could substantially alleviate PC12 cells injury and downregulate expression of AD-related genes.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2014 ;2014:150617. Epub 2014 Dec 17. PMID:
25580148
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Mulberry
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Mulberry leaf regulates differentially expressed genes in diabetic mice liver based on RNA-Seq analysis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Front Physiol. 2018 ;9:1051. Epub 2018 Aug 7. PMID:
30131712
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Mulberry
Diseases
:
Diabetic Complications
,
Liver Damage
Pharmacological Actions
:
Hepatoprotective
,
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Myricetin might represent an effective therapeutic agent to treat HFD-induced hepatic steatosis.
Dec 10, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2016 Dec 11 ;8(12). Epub 2016 Dec 11. PMID:
27973423
Article Published Date
: Dec 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Myricetin
Diseases
:
Hepatic Steatosis
,
High Fat Diet
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Gene Expression Regulation
[+]
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
May 16, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 May 17. Epub 2018 May 17. PMID:
29778538
Article Published Date
: May 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Naringenin
Diseases
:
Cardiac Hypertrophy
,
Diabetic Complications
Pharmacological Actions
:
Cardioprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Naringin was found to be an effective antidiabetic agent which increased Insulin gene expression and insulin secretion.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Cells Tissues Organs. 2018 ;206(3):133-143. Epub 2019 Mar 18. PMID:
30884485
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Citrus naringin
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Insulin-releasing
Additional Keywords
:
Gene Expression Regulation
[+]
Nigella sativa oil and thymoquinone treatment decreased albuminuria in experimental models of the diabetic nephropathy.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2016 Jun ;20(12):2680-8. PMID:
27383323
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
MicroRNA modulator
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Nobiletin could be used as an intervention that enhances circadian rhythms to combat metabolic disease via the circadian gene network.
Apr 11, 2016
Click here to read the entire abstract
Pubmed Data
: Cell Metab. 2016 Apr 12 ;23(4):610-21. PMID:
27076076
Article Published Date
: Apr 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nobiletin
Diseases
:
Metabolic Diseases
Additional Keywords
:
Circadian Rhythm
,
Gene Expression Regulation
,
Metabolic Diseases
,
Nobiletin
[+]
Noni leaf extract at 300mg/kg was more effective than Erlotinib for most of the parameters measured in this study.
Apr 21, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Apr 22. Epub 2016 Apr 22. PMID:
27106908
Article Published Date
: Apr 21, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Noni leaf extract
Diseases
:
Cancer Metastasis
,
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
,
Superiority of Natural Substances versus Drugs
[+]
Obese rats supplemented with bitter melon display marked shifts in the expression of genes controlling inflammatory response and lipid metabolism.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Genes Genomics. 2018 06 ;40(6):561-567. Epub 2018 Feb 20. PMID:
29892950
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Bitter Melon
Diseases
:
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Octacosanol and policosanol ameliorate diet-induced obesity and metabolic disorders.
Mar 25, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2019 Mar 26 ;9(1):5169. Epub 2019 Mar 26. PMID:
30914769
Article Published Date
: Mar 25, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Octacosanol
,
Policosanol
Diseases
:
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Okra powder could be useful intervention for improvement of ovaian dysfunction in diabetes.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Pharm Res. 2019 ;18(1):369-382. PMID:
31089371
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Okra
Diseases
:
Diabetes: Oxidative Stress
,
Diabetic Complications
,
High Fat Diet
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Additional Keywords
:
Gene Expression Regulation
[+]
Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice.
Jun 28, 2018
Click here to read the entire abstract
Pubmed Data
: Biochimie. 2018 Jun 29. Epub 2018 Jun 29. PMID:
29966735
Article Published Date
: Jun 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Oleanolic acid
Diseases
:
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
Additional Keywords
:
Gene Expression Regulation
[+]
Oligonol attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic mice.
Jan 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Discov Ther. 2015 Feb ;9(1):13-22. PMID:
25788048
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Lychee
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Glycation Agents
,
Renoprotective
Additional Keywords
:
Advanced Glycation End products (AGE)
,
Diabetes mellitus: Type 2
,
Gene Expression Regulation
,
Lychee
[+]
Oligonol derived from lychee alleviates muscle loss in diabetes.
Sep 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Sep 20 ;9(9). Epub 2017 Sep 20. PMID:
28930190
Article Published Date
: Sep 19, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lychee
,
Oligonol
Diseases
:
Diabetic Complications
,
Muscle Atrophy
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Oligonol may function to suppress MetS and the progression of geriatric diseases in western diet fed mice.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2016 Jul ;36(7):3705-13. PMID:
27354644
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lychee
,
Polyphenols
Diseases
:
Metabolic Syndrome X
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
Anti Therapeutic Actions
:
Western Diet
[+]
Oolong tea polyphenols ameliorate circadian rhythm of intestinal microbiome and liver clock genes in mouse model.
Oct 03, 2019
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2019 Oct 4. Epub 2019 Oct 4. PMID:
31583884
Article Published Date
: Oct 03, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Tea: Oolong
Diseases
:
Circadian Dysregulation
Additional Keywords
:
Gene Expression Regulation
[+]
Oral administration of a curcuminoid extract from C. xanthorrhiza and curcuminoid cider exerted promising hypocholesterolemic effects.
Jun 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacognosy Res. 2016 Jul-Sep;8(3):153-9. PMID:
27365981
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curcuminoids
,
Turmeric
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Antioxidants
Additional Keywords
:
Gene Expression Regulation
[+]
Oral administration of cinnamon powder may be beneficial in MS patients and that no other existing anti-MS therapies could be so economical and trouble free as this approach.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(1):e0116566. Epub 2015 Jan 8. PMID:
25569428
Article Published Date
: Dec 31, 2014
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Cinnamon
Diseases
:
Encephalomyelitis
,
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
,
Immunomodulatory: Th17 downregulation
Additional Keywords
:
Dose Response
,
Gene Expression Regulation
[+]
Oral curcumin intake could inhibit androgen receptor expression and probably PSA activity.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Korean J Urol. 2015 Sep ;56(9):656-65. Epub 2015 Aug 31. PMID:
26366279
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Androgen Antagonists
,
Antiproliferative
,
Wnt/β-catenin signaling pathway modulation
Additional Keywords
:
Gene Expression Regulation
[+]
Origanum Majoranum extract improved dyslipidemia associated with type 2 diabetes through regulation of genes related to glucose and lipid metabolism.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Pharm Res. 2016 ;15(Suppl):45-54. PMID:
28228803
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Marjoram
Diseases
:
Diabetes Mellitus: Type 2
,
Dyslipidemias
Pharmacological Actions
:
Hepatoprotective
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
P. incarnata extract positively modulates circadian rhythms by inducing high-amplitude rhythms in the expression of several circadian clock genes.
May 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Biomed Sci. 2017 Jun ;13(2):84-92. PMID:
28824345
Article Published Date
: May 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Diseases
:
Sleep Disorders
Additional Keywords
:
Circadian Rhythm
,
Gene Expression Regulation
[+]
Peach polyphenols inhibited tumor growth and reduced the risk of metastasis in MDA-MB-435 cells at levels achievable with diet.
Mar 18, 2014
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2014 Mar 19. Epub 2014 Mar 19. PMID:
24745759
Article Published Date
: Mar 18, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Peach
,
Polyphenols
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Anti-Tumor
,
Chemopreventive
,
Matrix Metalloproteinases Inhibitors
Additional Keywords
:
Breast Cancer Diet
,
Fruit Extract
,
Gene Expression Regulation
[+]
Phaseolus vulgaris lower non-HDL cholesterol in animals
May 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2019 Jun 1 ;149(6):996-1003. PMID:
31006805
Article Published Date
: May 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Common bean
Diseases
:
High Fat Diet
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Photobiomodulation may be beneficial for tendon healing because functional remodelling improves without adverse effects.
Jan 21, 2020
Click here to read the entire abstract
Pubmed Data
: J Orthop Res. 2020 Jan 22. Epub 2020 Jan 22. PMID:
31965620
Article Published Date
: Jan 21, 2020
Study Type
: Animal Study
Additional Links
Diseases
:
Tendon Injury
Therapeutic Actions
:
Laser Treatment: Low-Level
Additional Keywords
:
Gene Expression Regulation
[+]
Pistachio consumption is able to prevent and to ameliorate obesity-related dysfunctions.
Nov 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2018 Dec 1 ;10(12). Epub 2018 Dec 1. PMID:
30513740
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Pistachio nut
Diseases
:
Dyslipidemias
,
Fatty Liver
,
Obesity
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Polymerized nano-curcumin has significant effects on the EAE scores and myelin repair mechanisms in an animal model of multiple sclerosis.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2015 Dec ;99:156-67. Epub 2015 Jul 23. PMID:
26211978
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Demyelinating Diseases
,
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
,
Remyelination
Additional Keywords
:
Gene Expression Regulation
[+]
Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biochem Biophys Rep. 2020 Dec ;24:100825. Epub 2020 Oct 13. PMID:
33088927
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Urolithin A
,
Vitamin D
Additional Keywords
:
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Pomegranate flower polyphenols prevents high fat diet-induced obesity in Apo E-/- mice.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2017 ;9(6):3073-3083. Epub 2017 Jun 15. PMID:
28670394
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate flower
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Probiotic treatment might reduce diet-induced obesity and modulate genes associated with metabolism and inflammation in the liver and adipose tissue.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(3):e59470. Epub 2013 Mar 21. PMID:
23555678
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study
Additional Links
Diseases
:
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
,
Microbiota
[+]
PTHrP mediates energy wasting in fat tissues and contributes to the broader aspects of cancer cachexia.
Sep 03, 2014
Click here to read the entire abstract
Pubmed Data
: Nature. 2014 Sep 4 ;513(7516):100-4. Epub 2014 Jul 13. PMID:
25043053
Article Published Date
: Sep 03, 2014
Study Type
: Animal Study
Additional Links
Diseases
:
Cachexia
Additional Keywords
:
Gene Expression Regulation
,
Parathyroid-hormone-related Protein
[+]
Puerarin can decrease the blood glucose level of T2DM.
Jul 31, 2008
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2008 Aug ;33(16):2026-8, 2060. PMID:
19086646
Article Published Date
: Jul 31, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Puerarin
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Diabetes mellitus: Type 2
,
Gene Expression Regulation
,
Hypoglycemic Agents
,
Puerarin
[+]
Puerarin may be a potential therapeutic agent for the treatment of stroke.
Nov 13, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Nov 14. Epub 2016 Nov 14. PMID:
27844252
Article Published Date
: Nov 13, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Puerarin
Diseases
:
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Anti-Apoptotic
,
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Purified betacyanins from Hylocereus undatus peel ameliorate obesity and insulin resistance in high-fat-diet-fed mice.
Jan 12, 2016
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2016 Jan 13 ;64(1):236-44. Epub 2015 Dec 24. PMID:
26653843
Article Published Date
: Jan 12, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Dragon Fruit
Diseases
:
High Fat Diet
,
Insulin Resistance
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
,
Plant Extracts
Problem Substances
:
Insulin
[+]
Quercetin and green tea extract supplementation downregulates genes related to tissue inflammatory responses.
Jul 18, 2017
Click here to read the entire abstract
Pubmed Data
: Nutrients. 2017 Jul 19 ;9(7). Epub 2017 Jul 19. PMID:
28753942
Article Published Date
: Jul 18, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
,
Quercetin
Diseases
:
High Fat Diet
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet-induced obese mice.
Oct 25, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 Oct 26. Epub 2015 Oct 26. PMID:
26499876
Article Published Date
: Oct 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Quercetin
Diseases
:
Inflammation
,
Obesity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Red light modulates ultraviolet-induced gene expression in the epidermis of hairless mice.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: Photomed Laser Surg. 2015 Oct ;33(10):498-503. Epub 2015 Sep 23. PMID:
26398729
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study
Additional Links
Diseases
:
Ultraviolet Radiation Induced Damage
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Gene Expression Regulation
[+]
Red pitaya had beneficial effects on energy balance homeostasis by modulating the anorectic, orexigenic and energy expenditure related genes.
Jul 25, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2016 Jul 26 ;16:243. Epub 2016 Jul 26. PMID:
27456968
Article Published Date
: Jul 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Dragon Fruit
Diseases
:
High Fat Diet
,
Metabolic Syndrome X
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Red wine and black tea and polyphenolic extracts modulate COX-2, iNOS and GSH-related gene expression in tumors, suggesting also a possible chemotherapeutic activity of these compounds.
May 31, 2002
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr. 2002 Jun ;132(6):1376-9. PMID:
12042461
Article Published Date
: May 31, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Black Tea
,
Polyphenols
,
Red Wine
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemotherapeutic
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
,
Enzyme Inhibitors
,
Nitric Oxide Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Resveratrol may contribute towards the protection of hepatic cells from ethanol-induced oxidative stress.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Exp Ther Med. 2016 Apr ;11(4):1231-1238. Epub 2016 Feb 16. PMID:
27073428
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Alcohol Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Gene Expression Regulation
[+]
Routine consumption of guarana might be beneficial in protecting against mercury-induced toxicity.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Toxicol Res (Camb). 2016 Nov 1 ;5(6):1629-1638. Epub 2016 Aug 24. PMID:
28316775
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Guarana
Diseases
:
Mercury Poisoning
Pharmacological Actions
:
Antioxidants
,
Detoxifier
Additional Keywords
:
Gene Expression Regulation
,
Methylmercury
Problem Substances
:
Mercury
[+]
Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2020 Jan 1:e13138. Epub 2020 Jan 1. PMID:
31894585
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Royal Jelly
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Gene Expression Regulation
[+]
Royal jelly enhanced the antioxidant activities and modulated the gut microbiota in healthy mice.
Mar 30, 2021
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2021 Mar 31:e13701. Epub 2021 Mar 31. PMID:
33792081
Article Published Date
: Mar 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Royal Jelly
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Gastrointestinal Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Sesamin exerts anti-aging effects in the muscles, brain and midgut by inducing antioxidative and DNA repair genes.
Jan 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2019 Feb ;23(4):1826-1839. PMID:
30840309
Article Published Date
: Jan 31, 2019
Study Type
: Insect Study
Additional Links
Substances
:
Sesamin
Diseases
:
Aging
Pharmacological Actions
:
Antioxidants
,
DNA Repair Up-regulation
Additional Keywords
:
Gene Expression Regulation
[+]
Sesamum indicum oil and sesamin induce auditory-protective effects through changes in hearing loss-related gene expression.
Apr 30, 2020
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2020 May ;23(5):491-498. Epub 2020 Mar 18. PMID:
32186941
Article Published Date
: Apr 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sesame Seed Oil
Diseases
:
Hearing Loss
Additional Keywords
:
Gene Expression Regulation
[+]
Shiitake polysaccharide enhanced systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 Jun ;6(6):2068-80. PMID:
26034783
Article Published Date
: May 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Shiitake Mushroom
Pharmacological Actions
:
Immunomodulatory
,
Immunostimulatory
Additional Keywords
:
Gene Expression Regulation
,
Microbiota
[+]
Shiitake supplementation modulated the transcriptional profile of some genes involved in the cholesterol metabolism similarly to simvastatin.
Mar 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2016 Mar 9 ;64(9):1910-20. Epub 2016 Mar 1. PMID:
26877235
Article Published Date
: Mar 08, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Shiitake Mushroom
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substances Versus Drugs
[+]
Shikonin improved sepsis induced lung injury by regulation miRNA-140-5p/TLR4.
Nov 25, 2019
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Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Biochem. 2019 Nov 26. Epub 2019 Nov 26. PMID:
31769066
Article Published Date
: Nov 25, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Shikonin
Diseases
:
Lung Injury: Acute
,
Sepsis
Pharmacological Actions
:
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Silibinin can modulate TI-induced FAT10 expression and also restores normal chromosome numbers to cells treated with TI.
Jul 02, 2015
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Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Open. 2015 Jul 3. Epub 2015 Jul 3. PMID:
26142316
Article Published Date
: Jul 02, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Silibinin
Diseases
:
Cancers: All
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Antiproliferative
,
Chemopreventive
,
Genoprotective
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Chromosome
,
Cytokines
,
Gene Expression Regulation
[+]
Solanum glaucophyllum leaf administered to mice can elicit colon-specific enhancement of Cyp24a1 gene expression without inducing hypercalcemia through targeted delivery.
Mar 31, 2015
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Pubmed Data
: J Steroid Biochem Mol Biol. 2015 Apr ;148:318-25. Epub 2014 Nov 1. PMID:
25445916
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Solanum Glaucophyllum
,
Vitamin D3
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
,
Inflammatory Bowel Diseases
Additional Keywords
:
Dose Response
,
Gene Expression Regulation
[+]
Spirulina reduces diet-induced obesity through downregulation of lipogenic genes expression in Psammomys obesus.
Mar 23, 2020
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Pubmed Data
: Arch Physiol Biochem. 2020 Mar 24:1-9. Epub 2020 Mar 24. PMID:
32207345
Article Published Date
: Mar 23, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Spirulina
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Gene Expression Regulation
[+]
Steamed ginger can decrease plasma total cholesterol and triglyceride and can inhibit liver steatosis by regulating the expressions of hepatic genes.
Nov 30, 2018
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Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Res Pract. 2018 Dec ;12(6):503-511. Epub 2018 Nov 30. PMID:
30515278
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Ginger
Diseases
:
Liver Steatosis
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Supplementation of spirulina and whey protein concentrate could modulate DNA damage and gene expression caused by aflatoxins.
Apr 30, 2012
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Pubmed Data
: Ecotoxicol Environ Saf. 2012 May ;79:294-300. Epub 2012 Feb 9. PMID:
22325339
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Spirulina
,
Whey
Diseases
:
Aflatoxicosis
,
DNA damage
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Genoprotective
Additional Keywords
:
Gene Expression Regulation
Problem Substances
:
Aflatoxin
[+]
Synergistic cytotoxic activity of cannabinoids from cannabis sativa against cutaneous T-cell lymphoma.
Mar 30, 2020
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Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2020 Mar 31 ;11(13):1141-1156. Epub 2020 Mar 31. PMID:
32284791
Article Published Date
: Mar 30, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Lymphoma
Pharmacological Actions
:
Cytotoxic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Taurine could be a potential target to correct or ameliorate the disturbances in circadian rhythms caused by obesity.
Nov 17, 2016
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Article Publish Status
: This is a free article.
Click here to read the complet