Natural Substance Synergy

Name	AC	CK
Aluminum Chloride	2	4
Benzo(a)pyrene	2	4
Sodium Fluoride	2	4
Acetaminophen	1	2
Aflatoxin	1	2
Alloxan	1	2
Arsenite	1	2
Concanavalin A	1	2
Monosodium Glutamate (MSG)	1	2
Mycotoxin	1	2
Nicotine	1	2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2
Paracetamol	1	2
Antibiotics	1	1

Name	AC	CK
Oxidative Stress	35	65
Breast Cancer	34	49
Prostate Cancer	26	32
Inflammation	18	26
Cardiovascular Diseases	6	25
Lung Cancer	16	24
Osteoarthritis: Knee	3	21
C-Reactive Protein	2	20
Hyperlipidemia	6	20
Cognitive Decline/Dysfunction	6	19
Colon Cancer	17	19
Colorectal Cancer	9	19
Diabetic Complications	8	18
Breast Cancer: Triple Negative	9	17
Liver Cancer	11	17
Cervical Cancer	6	16
Cancers: All	12	14
Diabetes Mellitus: Type 2	8	14
Hypertension	3	14
Atherosclerosis	2	12
Cardiovascular Disease: Prevention	2	12
Hypercholesterolemia	2	12
Metabolic Diseases	2	12
Obesity	7	12
Vitamin D Deficiency	2	12
Alzheimer's Disease	8	11
Hyperglycemia	4	11
Aging Skin	1	10
Cholesterol: High	1	10
Cytomegalovirus Infections	1	10
Esophageal Cancer	1	10
Fibrosarcoma	1	10
Folic Acid/Folate Deficiency	1	10
Headache: Migraine	1	10
Herpes Simplex Virus Type 1	1	10
High Cholesterol	1	10
Homocysteine: Elevated	1	10
Irritable Bowel Syndrome	1	10
Morphine Tolerance/Dependence	1	10
Neurofibromatosis	1	10
Osteoarthritis	1	10
Polycystic Ovary Syndrome	1	10
Prostate: PSA Doubling	1	10
Prostatic Hyperplasia	1	10
Smoking Cessation: Nicotine Addiction	1	10
Urinary Tract Infections	1	10
Chemically-Induced Liver Damage	5	9
Lipid Peroxidation	5	9
Melanoma	7	9
Brain Inflammation	4	8
Diabetes: Oxidative Stress	4	8
Multiple Myeloma	3	8
Myocardial Infarction	4	8
Parkinson's Disease	5	8
Insulin Resistance	4	7
Neurodegenerative Diseases	5	7
Pancreatic Cancer	6	7
Acute Myeloid Leukemia	5	6
High Fat Diet	3	6
Promyelocytic leukemia	6	6
Sepsis	3	6
Wound Healing	3	6
Cancers: Drug Resistant	1	5
Cancers: Multi-Drug Resistant	1	5
Escherichia coli Infections	5	5
Head and Neck Cancer	3	5
Leukemia: Chronic myelogenous leukemia (CML)	1	5
Malaria	3	5
Oral Cancer	5	5
Staphylococcus aureus infection	5	5
Aluminum Toxicity	2	4
Cadmium Poisoning	2	4
Cancer Metastasis	2	4
Cerebral Ischemia	2	4
Cholestasis	2	4
Cholesterol: Oxidation	2	4
Diabetes Mellitus: Type 1	2	4
Dyslipidemias	2	4
Endothelial Dysfunction	2	4
Fluoride Toxicity	2	4
Gastric Cancer	4	4
Glioblastoma	3	4
Hypoglycemia	3	4
Liver Fibrosis	2	4
Prostate Cancer: Prevention	3	4
Triglycerides: Elevated	2	4
Ulcerative Colitis	2	4
Brain Ischemia	2	3
Candida Albicans	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Chronic Pain	2	3
Colon Cancer: Prevention	2	3
Colorectal Cancer: Prevention	2	3
DNA damage	2	3
Dementia	2	3
Human Papillomavirus (HPV)	2	3
Lipopolysaccharide-Induced Toxicity	3	3
Listeria Infections	3	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Osteoporosis	2	3
Squamous cell carcinoma	3	3
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging: Heart	1	2
Amyotrophic Lateral Sclerosis	1	2
Androgen-Induced Diseases	1	2
Arteriosclerosis	1	2
Avian Influenza	1	2
Bacterial Infections	1	2
Bowel Surgery	1	2
Brain Cancer	1	2
Breast Cancer: Chemically-Induced	2	2
Burns	1	2
Cancers	2	2
Candidiasis: Vulvovaginal	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chronic Myeloid Leukemia	1	2
Depressive Disorder	1	2
Diabetes	1	2
Diabetic Neuropathy	1	2
Dry Eye Syndromes	1	2
Emesis	1	2
Fructose-Induced Toxicity	1	2
Gallstones	1	2
Gout	1	2
Heart Failure	1	2
Hepatitis C	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hyperinsulinism	1	2
Hyperuricemia	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Influenza A	1	2
Iron Poisoning	1	2
Leishmaniasis	1	2
Leukemia	2	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	2	2
Liver Cancer: Prevention	1	2
Liver Cirrhosis	1	2
Liver Damage	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Damage: Drug-Induced	1	2
Liver Disease	1	2
Malignant Melanoma	1	2
Memory Disorders	1	2
Menopausal Syndrome	1	2
Motor Neuron Disease	1	2
Multiple Sclerosis	2	2
Myelotoxicity	1	2
Nasopharyngeal Cancer	1	2
Nicotine/Tobacco Toxicity	1	2
Peripheral Neuropathies	1	2
Salmonella Infections	2	2
Skin Cancer: Prevention	1	2
Stress	1	2
Ulcers	1	2
Vomiting	1	2
Abdominal Obesity (Midsection Fat)	1	1
Acinetobacter baumannii infection	1	1
Acute T cell Leukemias	1	1
Aging: Brain	1	1
Arthritis	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Brain Injury: Hippocampal Damage	1	1
Cancer Stem Cells	1	1
Candida Infection	1	1
Chagas Disease	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chronic Lymphocytic Leukemia	1	1
Dental Implantation	1	1
Encephalomyelitis	1	1
Endometrial Cancer	1	1
Food Poisoning	1	1
Gastrointestinal Inflammation	1	1
Gonorrhea	1	1
Gram-Positive Bacterial Infections	1	1
Kidney Cancer	1	1
Learning disorders	1	1
Leiomyosarcoma	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lymphoma	1	1
Micrococcus luteus infections	1	1
Neuroblastoma	1	1
Neurodevelopmental Disorders	1	1
Neurologic Disorders	1	1
Neurological Conditions	1	1
Non-Small-Cell Lung Carcinoma	1	1
Osteoclastoma	1	1
Osteopenia	1	1
Ovarian Cancer	1	1
Periodontitis	1	1
Photooxidative Stress	1	1
Pseudomonas aeruginosa	1	1
Renal Cancer	1	1
Rotavirus Infections	1	1
Skin Cancer	1	1
Tongue Cancer	1	1

Name	AC	CK	Focus
Radiotherapy	1	2

Name	AC	CK
Curcumin	75	150
Vitamin C	27	67
Resveratrol	32	52
Green Tea	15	50
Quercetin	30	49
Polyphenols	16	46
EGCG (Epigallocatechin gallate)	25	37
Vitamin D	25	34
Vitamin E	16	33
Frankincense	4	31
Omega-3 Fatty Acids	3	30
Turmeric	9	30
Vitamin B-12	3	30
Piperine	16	29
Selenium	12	27
Vitamin E: alpha tocopherol	6	27
Fish Oil	5	25
Ginkgo biloba	3	22
Catechin	13	20
Folic Acid	2	20
Lignans	2	20
Anthocyanins	7	19
Coenzyme Q10	4	16
Nigella sativa (aka Black Seed)	4	16
Olive Oil	4	15
Melatonin	11	14
Zinc	4	14
Black Pepper	3	13
EPA (Eicosapentaenoic Acid)	3	13
Luteolin	8	12
Riboflavin (Vitamin B-2)	3	12
Tocotrienol: Gamma	4	12
Cocoa	2	11
Cranberry	2	11
Cyanidin 3-glucoside	2	11
Milk Thistle	2	11
Vitamin E: Gamma-Tocopherol	2	11
Aloe Vera	1	10
Angelica	1	10
Apples	1	10
Chinese Herbal Formula: Jinye Baidu	1	10
Delphinidin	1	10
Egg	1	10
Fennel	1	10
Garlic	6	10
Haritaki (Terminalia chebula)	1	10
Hazelnut	1	10
Lactobacillus rhamnosus	1	10
Magnesium Sulfate	1	10
Mangosteen	1	10
NAC (N-acetyl-L-cysteine)	5	10
Nattokinase	1	10
Phosphatidylserine	1	10
Pine Cone	1	10
Pycnogenol (Pine Bark)	1	10
Red Yeast Rice	1	10
Soup	1	10
Thymoquinone	5	10
Vitamin B-5 (Pantothenic Acid)	1	10
acetyl-11-keto-beta-boswellic acid	1	10
Astragaloside	6	9
Fisetin	4	9
Flavonoids	7	9
Sulforaphane	8	9
Berberine	7	8
Cannabidiol	4	8
Delta-tetrahydrocannabinol (THC)	4	8
Ferulic acid	5	8
Artemisinin	5	7
Cucurbitacin B	2	7
Ginsenosides	4	7
Lycopene	4	7
Silibinin	5	7
Capsaicin	4	6
Fenugreek	3	6
Genistein	6	6
Pomegranate	4	6
Spirulina	3	6
Achiote	1	5
Alpha-Lipoic Acid	3	5
Amurensin G	1	5
Carnosic Acid	4	5
Chrysin	4	5
Citral	1	5
Gingerol	1	5
Ginseng	1	5
Grape Seed Extract	4	5
Hesperidin	3	5
Honey	3	5
Lemongrass	1	5
Lotus	3	5
Panaxadiol	1	5
Pterostilbene	4	5
Rosemary	3	5
Sesamin	1	5
Vitamin K	5	5
Apple Polyphenols	2	4
Arginine	2	4
Astragalus	2	4
Black Tea	2	4
Blackberry	2	4
Blueberry	3	4
Carotenoids	4	4
Cinnamon	3	4
Emodin	2	4
Ginger	4	4
Kaempferol	3	4
Onion	2	4
Oregano	3	4
Phenethyl isothiocyanate	3	4
Piceatannol	3	4
Puerarin	2	4
Red Clover	2	4
Red Sage	2	4
Reishi Mushroom	3	4
Sea buckthorn	3	4
Soy Protein	2	4
Tangeretin	3	4
Vitamin A	3	4
Artichoke	2	3
Astaxanthin	2	3
Beans: All	2	3
Bee Propolis	2	3
Cannabis	2	3
Chinese Skullcap	2	3
Citrus Peel	2	3
Clove	2	3
DHA (Docosahexaenoic Acid)	2	3
Fucoidan	2	3
Indole-3-Carbinol	2	3
Isoflavones	2	3
Isothiocyanates	3	3
Licorice	2	3
Medicinal Mushrooms	2	3
Mistletoe	2	3
Mugwort	2	3
Nobiletin	2	3
Olive	2	3
Silymarin	2	3
St. Johns Wort	2	3
Thyme	2	3
Tomato	3	3
Acai	2	2
Adlay	1	2
Andrographis	1	2
Arctigenin	2	2
Asiatic Acid	1	2
Bael	1	2
Baicalein	2	2
Bamboo	1	2
Bee Venom	2	2
Beta-glucan	1	2
Bisdemethoxycurcumin	1	2
Black Bean	1	2
Boswellia	1	2
Broccoli	2	2
Bromelain	2	2
Cannabinoids	1	2
Carnosine	1	2
Chamomile	1	2
Chlorogenic Acid	1	2
Chokeberry	2	2
Chrysanthemum Indicum	1	2
Coconut	1	2
Coptidis rhizoma	1	2
Creatine	1	2
Crocetin	1	2
Cumin	2	2
Daidzein	2	2
Dates	1	2
Eriodictyol	1	2
Fermented Foods and Beverages	1	2
Fruit: All	2	2
Fucoxanthin	1	2
Gardenia	1	2
Ginseng (Korean)	1	2
Glutamine	1	2
Glutathione	1	2
Glycoaminoglycans	1	2
Glycyrrhizin	1	2
Graviola	1	2
Guar gum	1	2
Hawthorn	1	2
Hedyotis corymbosa	1	2
Hibiscus sabdariffa	1	2
Holy Basil	1	2
Honokiol	2	2
Hu Zhang (Polygonum cuspidatum)	1	2
Huperzine	1	2
Insulin-like Growth Factor (IGF-1)	1	2
Irvingia gabonensis	1	2
Kahweol	2	2
Kudzu	1	2
L-Carnitine	1	2
Lemon	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Loquat	1	2
Lupeol	1	2
Lychee	1	2
Manganese	1	2
Marjoram	1	2
Mint	1	2
Myo-inositol	1	2
Niacin	1	2
Oats	1	2
Oleanolic acid	1	2
Olive leaf extract	1	2
Paeoniflorin	1	2
Parthenolide	1	2
Pea Protein	1	2
Peanut	1	2
Piperlongumine	2	2
Polyunsaturated Fatty Acids (PUFAs)	2	2
Pomegranate Peel	1	2
Pumpkin	1	2
Purple Carrots	1	2
Rhubarb	1	2
Rose Hips	2	2
Rutin	2	2
Sage	2	2
Shiitake Mushroom	1	2
Spikenard	1	2
Tamarind	1	2
Taurine	1	2
Ursolic Acid	2	2
Vitamin K2	1	2
Water: Deuterium Depleted	1	2
Yerba Santa	1	2
Zeolite	1	2
Acerola	1	1
Anise	1	1
Antioxidant formulas	1	1
Apigenin	1	1
Apple	1	1
Bai Zhu	1	1
Bay leaf	1	1
Beet	1	1
Benzyl isothiocyanate	1	1
Berries: All	1	1
Beta Sitosterol	1	1
Beta-Caryophyllene	1	1
Beta-Elemene	1	1
Betulinic acid	1	1
Black Currant	1	1
Black Tea Theaflavins	1	1
Burdock	1	1
Butyrate	1	1
Caffeine	1	1
Caffeoylquinic Acids	1	1
Camu Camu	1	1
Cardamom	1	1
Carnosine	1	1
Carsonic Acid	1	1
Carvacrol	1	1
Cherry: All Varieties	1	1
Chitosan	1	1
Chlorella (Algae)	1	1
Coffee	1	1
Copper	1	1
Cordyceps Militaris	1	1
Coriandor	1	1
Cranberry Proanthocyanidins	1	1
Cryptoxanthin	1	1
Culinary Herbs and Spices	1	1
Curcuma Longa	1	1
D-Limonene	1	1
Dandelion	1	1
Diallyl sulfide	1	1
Diosgenin	1	1
Ellagic Acid	1	1
Eugenol	1	1
Evodiamine	1	1
Fig	1	1
Garcinia dulcis	1	1
Gold (nanoparticles)	1	1
Grapes	1	1
Guava	1	1
Hydrogen Peroxide	1	1
Inositol Hexaphosphate	1	1
Kimchi	1	1
Lactobacillus casei	1	1
Lactobacillus rhamnosus GG	1	1
Lavender: Essential Oil	1	1
Lecithin	1	1
Lettuce	1	1
Lingonberry	1	1
Long Pepper	1	1
Lutein	1	1
Magnolol	1	1
Maitake Mushroom	1	1
Mango	1	1
Milk	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Modified Citrus Pectin	1	1
Modified Rice Bran (MGN-3)	1	1
Monolaurin	1	1
Mulberry	1	1
Mustard Oil	1	1
Myricetin	1	1
Naringenin	1	1
Nettle	1	1
Nisin	1	1
Noni	1	1
Onions	1	1
Orange: Mandarin	1	1
Oridonin	1	1
Palmitoylethanolamide	1	1
Papain	1	1
Plum	1	1
Potassium	1	1
Psychedelics:All	1	1
Raspberry	1	1
Rice Bran	1	1
Rooibos	1	1
Rose	1	1
S-Adenosylmethionine (SAMe)	1	1
Saffron	1	1
Stilbenes	1	1
Strawberry	1	1
Tea	1	1
Testosterone	1	1
Theaflavins	1	1
Thiamine (B-1)	1	1
Thujae occidentalis	1	1
Toad	1	1
Tocopherols	1	1
Tocotrienol: Delta	1	1
Tomatidine	1	1
Ubiquinol	1	1
Vanadium	1	1
Vegetables: All	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin E: delta-tocopherol	1	1
Walnut	1	1
Water: Deep Sea	1	1
Watercress	1	1
Whey	1	1
Yeast	1	1
Zataria multiflora	1	1
beta-Carotene	1	1

Name	AC	CK
Aromatherapy	1	10
Mediterranean diet	1	10
Light Therapy	2	4
Acupuncture	1	2
Exercise: Endurance	1	2

Name	AC	CK
Apoptotic	96	148
Antioxidants	77	143
Antiproliferative	91	135
Anti-Inflammatory Agents	39	112
Neuroprotective Agents	34	66
Antineoplastic Agents	21	46
Chemopreventive	30	44
Anticholesteremic Agents	7	38
Cell cycle arrest	25	38
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	37
Anticarcinogenic Agents	18	34
Hepatoprotective	18	34
Interleukin-6 Downregulation	13	33
Hypoglycemic Agents	13	31
Antihypertensive Agents	5	26
Hypolipidemic	9	26
NF-kappaB Inhibitor	20	26
Cardioprotective	10	25
Antiviral Agents	4	23
Interleukin-1 beta downregulation	7	20
Chemotherapeutic	7	19
Immunomodulatory	10	19
Chemosensitizer	9	18
Nrf2 activation	7	18
Analgesics	4	15
Cyclooxygenase 2 Inhibitors	13	15
Tumor Suppressor Protein p53 Upregulation	8	13
Anti-metastatic	9	11
Anti-Bacterial Agents	9	10
Anti-Infective Agents	1	10
Dermatologic Agents	1	10
Vascular Cell Adhesion Molecule-1 Inhibitor	1	10
Angiogenesis Inhibitors	5	9
Anti-Apoptotic	4	8
Antimicrobial	8	8
Renoprotective	4	8
Vascular Endothelial Growth Factor Inhibitors	4	8
Antinoceceptive	4	7
Chemoprotective Agents	4	7
Anti-Fibrotic	3	6
Anti-Tumor	3	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	6
MicroRNA modulator	4	6
Vasodilator Agents	3	6
Bcl-2 protein down-regulation	5	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	5
Cytoprotective	2	4
Cytotoxic	3	4
Interleukin-8 downregulation	3	4
Superoxide Dismutase Up-regulation	2	4
Vascular Endothelial Growth Factor A Inhibitor	3	4
Alpha-amylase inhibitor	2	3
Caspase-3 Activation	3	3
Gastroprotective	2	3
Heme oxygenase-1 up-regulation	2	3
Acetylcholinesterase Inhibitor	1	2
Anti-Adipogenic	2	2
Anti-Angiogenic	1	2
Anti-Ulcer Agents	1	2
Anti-atherogenic	1	2
Antidepressive Agents	1	2
Antifungal Agents	1	2
Antioxidant	1	2
Autophagy Up-regulation	2	2
Bax/Bcl2 Ratio: Decrease	1	2
Bone Density Conservation Agents	1	2
Brain-derived neurotrophic factor modulator	1	2
Cardiovascular Agents	1	2
Detoxifier	1	2
Genoprotective	1	2
Immunostimulatory	1	2
Insulin Sensitizers	1	2
Interferon-gamma (IFN-gamma) inducer	1	2
Leishmanicidal	1	2
Malondialdehyde Down-regulation	1	2
Neurorestorative	1	2
Nitric Oxide Inhibitor	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Prophylactic Agents	1	2
Radioprotective	1	2
Radiosensitizer	1	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor Regulator	1	2
Wnt/β-catenin pathway down-regulation	1	2
12-lipoxygenase (12-LOX) Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anabolic Agents	1	1
Anti-cancer	1	1
Antimalarials	1	1
Antiprotozoal Agents	1	1
Cyclin D1 Down-Regulation	1	1
Cyclooxygenase Inhibitors	1	1
Enzyme Inhibitors	1	1
Estrogen Receptor Agonist	1	1
Heat Shock Protein Inducer	1	1
Interleukin-10 downregulation	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
Neuritogenic	1	1
P21 Activation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Photoprotective	1	1
Postaglandin PGE2 downregulation	1	1
SIRT1 Activator	1	1
STAT3 Inhibitor	1	1
Survivin Down-Regulation	1	1
TRAIL sensitizer	1	1
Telomerase Upregulation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vascular smooth muscle cell (VSMC) inhibitor	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2012 ;64(4):550-8. Epub 2012 Apr 20. PMID: 22519865

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Folic Acid , Vitamin B-12

Diseases : Cervical Cancer, Folic Acid/Folate Deficiency

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance Synergy

[+]

A combination of curcumin and fennel essential oil significantly improved symptoms and quality of life in IBS patients over 30 days.May 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Gastrointestin Liver Dis. 2016 Jun ;25(2):151-7. PMID: 27308645

Article Published Date : May 31, 2016

Study Type : Human Study

Additional Links

Substances : Curcumin, Fennel

Diseases : Irritable Bowel Syndrome

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Essential Oils, Natural Substance Synergy, Significant Treatment Outcome

[+]

A combination of green tea and ginkgo biloba extracts effectively improved skin conditions and the improvement of skin elasticity.Aug 31, 2014

Click here to read the entire abstract

Pubmed Data : J Drugs Dermatol. 2014 Sep ;13(9):1092-7. PMID: 25226010

Article Published Date : Aug 31, 2014

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba, Green Tea

Diseases : Aging Skin

Pharmacological Actions : Antioxidants, Dermatologic Agents

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

A combination of selenium and silymari led to a significant reduction in PSA levels.Dec 14, 2013

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2013 Dec 15 ;21(1):75-81. Epub 2013 Sep 5. PMID: 24012146

Article Published Date : Dec 14, 2013

Study Type : Human Study

Additional Links

Substances : Milk Thistle, Selenium

Diseases : Prostate: PSA Doubling, Prostatic Hyperplasia

Additional Keywords : Natural Substance Synergy, Phytotherapy, Plant Extracts

[+]

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Nutr. 2015 Jan ;3(1):32-8. Epub 2014 Dec 12. PMID: 25649891

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Aloe Vera, Green Tea, Mangosteen, Riboflavin (Vitamin B-2), Vitamin B-5 (Pantothenic Acid)

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Natural Substance Synergy

[+]

A herbal formulation is a safe and effective intervention for management of joint discomfort.Apr 30, 2018

Click here to read the entire abstract

Pubmed Data : J Med Food. 2018 May ;21(5):511-520. Epub 2018 Apr 30. PMID: 29708818

Article Published Date : Apr 30, 2018

Study Type : Human Study

Additional Links

Substances : Frankincense, Haritaki (Terminalia chebula), Turmeric

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

A joint consumption of apple juice, natural antioxidants and polyphenols might provide mild favorable effects on cardiometabolic markers, as compared to apple polyphenols alone.Nov 30, 2014

Click here to read the entire abstract

Pubmed Data : Eur J Nutr. 2014 Dec ;53(8):1645-57. Epub 2014 Feb 16. PMID: 24531755

Article Published Date : Nov 30, 2014

Study Type : Human Study

Additional Links

Substances : Apples, Polyphenols, Vitamin C

Pharmacological Actions : Anticholesteremic Agents, Antioxidants

Additional Keywords : Fruit Juice, Natural Substance Synergy

[+]

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2013 Sep ;23(9):843-9. Epub 2012 Aug 17. PMID: 22906565

Article Published Date : Aug 31, 2013

Study Type : Human Study

Additional Links

Substances : Anthocyanins, Cyanidin 3-glucoside, Delphinidin

Diseases : Atherosclerosis, C-Reactive Protein, High Cholesterol, Hypercholesterolemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Vascular Cell Adhesion Molecule-1 Inhibitor

Additional Keywords : Dose Response, Natural Substance Synergy

[+]

Coenzyme Q10 and vitamin E had beneficial effects on cardiometabolic outcomes among women with polycystic ovary syndrome.Jan 31, 2019

Click here to read the entire abstract

Pubmed Data : Arch Med Res. 2019 Feb ;50(2):1-10. Epub 2019 May 21. PMID: 31349945

Article Published Date : Jan 31, 2019

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Vitamin E

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Hypolipidemic

Additional Keywords : Natural Substance Synergy

[+]

Constitutes of Boswellia serrata extract act synergistically to exert anti-inflammatory/anti-arthritic activity.Mar 05, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytother Res. 2019 Mar 6. Epub 2019 Mar 6. PMID: 30838706

Article Published Date : Mar 05, 2019

Study Type : Human Study

Additional Links

Substances : acetyl-11-keto-beta-boswellic acid, Frankincense

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substance Synergy

[+]

CoQ10 and vitamin E supplementation had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels.Sep 06, 2018

Click here to read the entire abstract

Pubmed Data : J Clin Endocrinol Metab. 2018 Sep 7. Epub 2018 Sep 7. PMID: 30202998

Article Published Date : Sep 06, 2018

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Vitamin E

Diseases : Polycystic Ovary Syndrome

Additional Keywords : Natural Substance Synergy

[+]

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2013 Aug ;19(8):709-13. Epub 2013 Mar 28. PMID: 23536963

Article Published Date : Jul 31, 2013

Study Type : Human Study

Additional Links

Substances : Angelica, Black Pepper

Diseases : Smoking Cessation: Nicotine Addiction

Therapeutic Actions : Aromatherapy

Additional Keywords : Natural Substance Synergy

[+]

Gazpacho soup consumption is associated with a lower prevalence of hypertension.Sep 30, 2013

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2013 Oct ;23(10):944-52. Epub 2012 Nov 11. PMID: 23149074

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Substances : Polyphenols, Soup

Diseases : Cardiovascular Diseases, Hypertension

Pharmacological Actions : Antihypertensive Agents

Additional Keywords : Natural Substance Synergy

[+]

Increased dietary ω-3 polyunsaturated fatty acids and extra virgin olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Nutrition. 2015 Jun ;31(6):834-40. Epub 2015 Jan 3. PMID: 25933490

Article Published Date : May 31, 2015

Study Type : Human Study

Additional Links

Substances : Fish Oil, Olive Oil

Diseases : Cholesterol: High, Oxidative Stress

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Natural Substance Synergy

[+]

Magnesium sulphate increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.Nov 20, 2016

Click here to read the entire abstract

Pubmed Data : Pain Manag. 2016 Nov 21. Epub 2016 Aug 21. PMID: 27866449

Article Published Date : Nov 20, 2016

Study Type : Human Study

Additional Links

Substances : Magnesium Sulfate

Diseases : Morphine Tolerance/Dependence

Additional Keywords : Natural Substance Synergy

[+]

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID: 25625225

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Fibrosarcoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Gerontol A Biol Sci Med Sci. 2016 Feb ;71(2):236-42. Epub 2015 Aug 11. PMID: 26265727

Article Published Date : Jan 31, 2016

Study Type : Human Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid), Folic Acid , Ginkgo biloba, Omega-3 Fatty Acids, Phosphatidylserine, Vitamin B-12, Vitamin E: alpha tocopherol

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Asia Pac J Clin Nutr. 2009;18(3):310-7. PMID: 19786378

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Substances : Nattokinase, Red Yeast Rice

Diseases : Hyperlipidemia

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Natural Substance Synergy

[+]

Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.Oct 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2009 Nov-Dec;23(6):1011-6. PMID: 20023248

Article Published Date : Oct 31, 2009

Study Type : Human Study

Additional Links

Substances : Lignans, Pine Cone, Vitamin C

Diseases : Herpes Simplex Virus Type 1

Pharmacological Actions : Anti-Infective Agents, Antiviral Agents

Additional Keywords : Natural Substance Synergy, Plant Extracts, Recurrence Risk, Significant Treatment Outcome

[+]

Study suggests link between tea consumption and vitamin D levelsAug 19, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr J. 2012 Aug 20 ;11(1):56. Epub 2012 Aug 20. PMID: 22905922

Article Published Date : Aug 19, 2012

Study Type : Human Study

Additional Links

Substances : Green Tea

Diseases : Vitamin D Deficiency

Additional Keywords : Natural Substance Synergy

[+]

The administration of cranberries, L. rhamnosus, and vitamin C might represent a safe and effective option in women with recurrent UTIs.Jun 06, 2016

Click here to read the entire abstract

Pubmed Data : Eur Urol. 2016 Jun 7. Epub 2016 Jun 7. PMID: 27283213

Article Published Date : Jun 06, 2016

Study Type : Human Study

Additional Links

Substances : Cranberry, Lactobacillus rhamnosus , Vitamin C

Diseases : Urinary Tract Infections

Additional Keywords : Natural Substance Synergy

[+]

The combination hazelnut and cocoa may act in a synergic and protective way on cardiovascular system.Jul 08, 2017

Click here to read the entire abstract

Pubmed Data : Int J Food Sci Nutr. 2017 Jul 9:1-12. Epub 2017 Jul 9. PMID: 28691541

Article Published Date : Jul 08, 2017

Study Type : Human Study

Additional Links

Substances : Cocoa, Hazelnut

Diseases : Cardiovascular Disease: Prevention

Pharmacological Actions : Cardioprotective

Additional Keywords : Natural Substance Synergy

[+]

The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Complement Ther Med. 2015 Apr ;23(2):165-74. Epub 2015 Jan 14. PMID: 25847554

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Turmeric

Diseases : Metabolic Diseases

Pharmacological Actions : Antihypertensive Agents, Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Natural Substance Synergy, Significant Treatment Outcome

[+]

The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of homocysteine.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asia Pac J Clin Nutr. 2015 ;24(3):403-11. PMID: 26420180

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Fish Oil, Omega-3 Fatty Acids, Vitamin B-12

Diseases : C-Reactive Protein, Cardiovascular Diseases, Homocysteine: Elevated

Additional Keywords : Natural Substance Synergy

[+]

The consumption of cooked whole eggs is an effective way to increase the absorption of α-tocopherol and γ-tocopherol from foods.Oct 31, 2016

Click here to read the entire abstract

Pubmed Data : J Nutr. 2016 Nov ;146(11):2199-2205. Epub 2016 Aug 21. PMID: 27655756

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Substances : Egg, Vitamin E: alpha tocopherol, Vitamin E: Gamma-Tocopherol

Additional Keywords : Food Bioavailability Enhancers, Natural Substance Synergy

[+]

The consumption of nuts is associated with better dietary and lifestyle patterns in Polish adults.Jun 21, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Jun 22 ;11(6). Epub 2019 Jun 22. PMID: 31234530

Article Published Date : Jun 21, 2019

Study Type : Human Study

Additional Links

Substances : Nuts: All

Additional Keywords : Natural Substance Synergy

[+]

The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancersNov 30, 2014

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2014 Dec ;112(12):2002-9. Epub 2014 Oct 27. PMID: 25345471

Article Published Date : Nov 30, 2014

Study Type : Human Study

Additional Links

Substances : Lignans, Quercetin, Resveratrol

Diseases : Esophageal Cancer

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Dietary Modification, Natural Substance Synergy, Plant Extracts

[+]

There is a synergistic interplay between curcumin and polyphenol-rich foods in the Mediterranean diet.Jul 20, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2017 Jul 21 ;9(7). Epub 2017 Jul 21. PMID: 28754004

Article Published Date : Jul 20, 2017

Study Type : Human Study

Additional Links

Substances : Curcumin, Polyphenols

Diseases : Neurofibromatosis

Therapeutic Actions : Mediterranean diet

Additional Keywords : Natural Substance Synergy, Significant Treatment Outcome

[+]

These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.Jun 25, 2019

Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2019 Jun 26:1-10. Epub 2019 Jun 26. PMID: 31241007

Article Published Date : Jun 25, 2019

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Curcumin

Diseases : Headache: Migraine

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Prophylactic Agents

Additional Keywords : Natural Substance Synergy

[+]

Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with osteoarthritis.Jan 08, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2018 Jan 9 ;18(1):7. Epub 2018 Jan 9. PMID: 29316908

Article Published Date : Jan 08, 2018

Study Type : Human Study

Additional Links

Substances : Curcumin, Frankincense

Diseases : Osteoarthritis

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance Synergy

[+]

Zinc and the Chinese herbal formula Jinye Baidu granule significantly increase the negative conversion rate of HCMV-IgM.May 01, 2005

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 May;25(5):449-51. PMID: 15957842

Article Published Date : May 01, 2005

Study Type : Human Study

Additional Links

Substances : Chinese Herbal Formula: Jinye Baidu, Zinc

Diseases : Cytomegalovirus Infections

Pharmacological Actions : Antiviral Agents

Additional Keywords : Natural Substance Synergy

[+]

ω-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.May 31, 2017

Click here to read the entire abstract

Pubmed Data : Immunogenetics. 2017 Jun ;69(6):371-378. Epub 2017 May 6. PMID: 28478481

Article Published Date : May 31, 2017

Study Type : Human Study

Additional Links

Substances : Curcumin, Omega-3 Fatty Acids

Diseases : Headache: Migraine

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2012 Aug 1 ;84(3):402-10. Epub 2012 Mar 29. PMID: 22483777

Article Published Date : Jul 31, 2012

Study Type : Human In Vitro

Additional Links

Substances : Amurensin G

Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Apoptotic, Chemosensitizer

Additional Keywords : Cancer Stem Cells, Gene Expression Regulation, Natural Substance Synergy

[+]

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Click here to read the entire abstract

Pubmed Data : J Med Food. 2017 Jun 26. Epub 2017 Jun 26. PMID: 28650731

Article Published Date : Jun 25, 2017

Study Type : Human In Vitro

Additional Links

Substances : Fisetin, Luteolin

Diseases : Diabetic Complications, Hyperglycemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma.Oct 05, 2015

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2015 Oct 6. Epub 2015 Oct 6. PMID: 26452516

Article Published Date : Oct 05, 2015

Study Type : Human In Vitro

Additional Links

Substances : Cucurbitacin B , Curcumin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Multidrug Resistance, Natural Substance Synergy

[+]

Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.Aug 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Breast Cancer. 2015 Sep ;18(3):225-34. Epub 2015 Sep 24. PMID: 26472972

Article Published Date : Aug 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Citral, Curcumin, Lemongrass

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Dose Response, Natural Substance Synergy, Selective Cytotoxicity

[+]

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.May 08, 2012

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2012 May 8. Epub 2012 May 8. PMID: 22566066

Article Published Date : May 08, 2012

Study Type : Human In Vitro

Additional Links

Substances : Catechin , EGCG (Epigallocatechin gallate), Ginseng, Green Tea, Panaxadiol

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance Synergy

[+]

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxid Redox Signal. 2010 Oct 1 ;13(7):987-97. PMID: 20170403

Article Published Date : Sep 30, 2010

Study Type : Human In Vitro

Additional Links

Substances : Achiote, NAC (N-acetyl-L-cysteine)

Diseases : Cancers: Multi-Drug Resistant, Multiple Myeloma, Oxidative Stress

Pharmacological Actions : Antineoplastic Agents, Apoptotic

Additional Keywords : Natural Substance Synergy, Phytotherapy, Plant Extracts, Selective Cytotoxicity

[+]

The synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells was cytostatic, not cytotoxic.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Fitoterapia. 2013 Jan ;84:347-59. Epub 2012 Dec 22. PMID: 23266736

Article Published Date : Dec 31, 2012

Study Type : Human In Vitro, In Vitro Study

Additional Links

Substances : Sesamin, Tocotrienol: Gamma

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance Synergy

[+]

γ-tocotrienol and 6-gingerol when used in combination act synergistically increasing cytotoxicity and apoptosis in cancer cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2015 ;20(6):10280-97. Epub 2015 Jun 3. PMID: 26046324

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Gingerol , Tocotrienol: Gamma

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Irvingia gabonensis extract has an analgesic effect.Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2009 Jun;47(6):1176-1183. PMID: 7776661

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Irvingia gabonensis

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

A combination of black bean peel and pomegranate peel extracts, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress induced damage to the pancreas.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2015 Jan ;9(1):43-48. Epub 2014 Oct 30. PMID: 25452774

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Beans: All , Black Bean, Pomegranate Peel

Diseases : Diabetes, Diabetes: Oxidative Stress, Hyperglycemia

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83. PMID: 25384193

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Turmeric

Diseases : Dyslipidemias, Endothelial Dysfunction, Fructose-Induced Toxicity , Hyperglycemia, Hyperinsulinism, Hypertension, Metabolic Diseases

Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents, Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Natural Substance Synergy, Risk Reduction

[+]

A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.Sep 01, 2016

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2016 Sep 2:1-9. Epub 2016 Sep 2. PMID: 27875075

Article Published Date : Sep 01, 2016

Study Type : Animal Study

Additional Links

Substances : Chamomile, Oregano

Diseases : Diabetic Complications

Pharmacological Actions : Alpha-amylase inhibitor, Anti-Apoptotic, Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Natural Substance Synergy, Plant Extracts

Problem Substances : Alloxan

[+]

A combination of five main alkaloids from Rhizoma Coptidis showed a synergetic cholesterol-lowering efficacy.Apr 14, 2016

Click here to read the entire abstract

Pubmed Data : Life Sci. 2016 Apr 15 ;151:50-60. Epub 2016 Feb 11. PMID: 26876917

Article Published Date : Apr 14, 2016

Study Type : Animal Study

Additional Links

Substances : Coptidis rhizoma

Diseases : Cardiovascular Disease: Prevention, Hypercholesterolemia, Hyperlipidemia

Pharmacological Actions : Anticholesteremic Agents, Hepatoprotective, Hypolipidemic

Additional Keywords : Natural Substance Synergy

[+]

A combination of lycopene and vitamin E acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : J Alzheimers Dis. 2017 ;57(2):475-482. PMID: 28269786

Article Published Date : Dec 31, 2016

Study Type : Transgenic Animal Study

Additional Links

Substances : Lycopene, Vitamin E

Diseases : Alzheimer's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

Click here to read the entire abstract

Pubmed Data : Metab Brain Dis. 2015 Jul 30. Epub 2015 Jul 30. PMID: 26220010

Article Published Date : Jul 29, 2015

Study Type : Animal Study

Additional Links

Substances : Ferulic acid, Piperine

Diseases : Depressive Disorder

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

[+]

A combination of pomegranate, date fruit and date seeds led to a more potent treatment result than each alone. Mar 25, 2015

Click here to read the entire abstract

Pubmed Data : Food Funct. 2015 Mar 26. Epub 2015 Mar 26. PMID: 25811166

Article Published Date : Mar 25, 2015

Study Type : Animal Study

Additional Links

Substances : Dates, Polyphenols, Pomegranate

Diseases : Atherosclerosis, Oxidative Stress, Triglycerides: Elevated

Pharmacological Actions : Anti-atherogenic, Anticholesteremic Agents, Antioxidants

Additional Keywords : Natural Substance Synergy

[+]

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.Feb 06, 2017

Click here to read the entire abstract

Pubmed Data : J Alzheimers Dis. 2017 Feb 7. Epub 2017 Feb 7. PMID: 28222524

Article Published Date : Feb 06, 2017

Study Type : Animal Study

Additional Links

Substances : Curcumin, Resveratrol

Diseases : Aluminum Toxicity , Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

Problem Substances : Aluminum Chloride

[+]

A curcumin-artemisinin combination is effective for malaria. May 01, 2006

Click here to read the entire abstract

Pubmed Data : Antimicrob Agents Chemother. 2006 May;50(5):1859-60. PMID: 16641461

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Artemisinin, Curcumin

Diseases : Malaria

Additional Keywords : Natural Substance Synergy

[+]

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Biotechnol. 2018 Aug ;27(4):1193-1200. Epub 2018 Apr 4. PMID: 30263850

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean), Kudzu

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Wiad Lek. 2017;70(2):200-204. PMID: 28511159

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Apple Polyphenols, Catechin , EGCG (Epigallocatechin gallate), Quercetin

Diseases : Insulin Resistance

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

A sea buckthorn and olive oil mixture could be considered as an alternative dressing for full-thickness burns.Jun 30, 2014

Click here to read the entire abstract

Pubmed Data : Adv Skin Wound Care. 2014 Jul ;27(7):317-23. PMID: 24932952

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : Olive Oil, Sea buckthorn

Diseases : Burns, Wound Healing

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance Synergy

[+]

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria.Feb 29, 2012

Click here to read the entire abstract

Pubmed Data : Int J Mol Med. 2012 Mar ;29(3):447-53. Epub 2011 Dec 5. PMID: 22160132

Article Published Date : Feb 29, 2012

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Immune Dysregulation: TH1/TH2 imbalance

Pharmacological Actions : Immunomodulatory

Additional Keywords : Natural Substance Synergy

[+]

ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with AI or CL alone.Jul 22, 2015

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2015 Jul 23. Epub 2015 Jul 23. PMID: 26212022

Article Published Date : Jul 22, 2015

Study Type : Animal Study

Additional Links

Substances : Mugwort, Turmeric

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

Additional Keywords : Natural Substance Synergy

[+]

Administration of melatonin and vitamin C as radioprotectors before irradiation may reduce genotoxicity caused by x-ray irradiation.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell J. 2016 ;18(1):46-51. Epub 2016 Apr 4. PMID: 27054118

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin, Vitamin C

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Radioprotective

Additional Keywords : Natural Substance Synergy

Anti Therapeutic Actions : Radiotherapy

[+]

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2011 ;6(12):e29240. Epub 2011 Dec 14. PMID: 22195029

Article Published Date : Dec 31, 2010

Study Type : Animal Study

Additional Links

Substances : Vitamin C, Vitamin E

Diseases : Hyperalgesia, Inflammation, Peripheral Neuropathies

Pharmacological Actions : Analgesics, Antinoceceptive

Additional Keywords : Natural Substance Synergy

[+]

Amelioration of oxidative stress by dietary fenugreek seeds is potentiated by onion in streptozotocin-induced diabetic rats.Mar 19, 2017

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Pubmed Data : Appl Physiol Nutr Metab. 2017 Mar 20. Epub 2017 Mar 20. PMID: 28319671

Article Published Date : Mar 19, 2017

Study Type : Animal Study

Additional Links

Substances : Fenugreek, Onion

Diseases : Diabetes: Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance Synergy

[+]

Andrographis and Hedyotis corymbosa in combination with curcumin have anti-malaria action.Feb 01, 2004

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Pubmed Data : Phytother Res. 2004 Feb;18(2):164-8. PMID: 19216765

Article Published Date : Feb 01, 2004

Study Type : Animal Study

Additional Links

Substances : Andrographis, Curcumin, Hedyotis corymbosa

Diseases : Malaria

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

Antioxidants exhibited protective effects against D-galactose-induced oxidative damage in rats.Mar 29, 2016

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Pubmed Data : Biol Trace Elem Res. 2016 Mar 30. Epub 2016 Mar 30. PMID: 27025718

Article Published Date : Mar 29, 2016

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Purple Carrots, Selenium, Vitamin E

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

Additional Keywords : Natural Substance Synergy

[+]

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2006 Nov 14 ;12(42):6835-41. PMID: 17106933

Article Published Date : Nov 13, 2006

Study Type : Animal Study

Additional Links

Substances : Vitamin C, Vitamin E

Diseases : Cholestasis, Liver Cirrhosis, Oxidative Stress

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Apple polyphenol extracts might emerge as a promising nutritional ingredient in the management of chronic diseases such as diabetes.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Metab (Lond). 2016 ;13:32. Epub 2016 Apr 30. PMID: 27141227

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apple Polyphenols

Diseases : Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

Artemisinin and curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity.Jun 30, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : IUBMB Life. 2014 Jul ;66(7):496-506. Epub 2014 Jun 27. PMID: 24975030

Article Published Date : Jun 30, 2014

Study Type : Insect Study

Additional Links

Substances : Artemisinin, Curcumin

Diseases : Brain Cancer

Pharmacological Actions : Antineoplastic Agents

Additional Keywords : Natural Substance Synergy

[+]

Artificial tears containing epigallocatechin gallate and hyaluronic acid had a synergistic effect in the treatment of dry eye syndrome.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016;11(6):e0157982. Epub 2016 Jun 23. PMID: 27336157

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Dry Eye Syndromes

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Astaxanthin reduces the susceptibility to oxidation and potentizes the immunomodulatory properties of fish oil. Oct 05, 2011

Click here to read the entire abstract

Pubmed Data : Eur J Nutr. 2011 Oct 5. Epub 2011 Oct 5. PMID: 21972007

Article Published Date : Oct 05, 2011

Study Type : Animal Study

Additional Links

Substances : Astaxanthin, Fish Oil

Diseases : Oxidative Stress

Pharmacological Actions : Immunomodulatory, Interleukin-1 beta downregulation

Additional Keywords : Natural Substance Synergy

[+]

Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2017 02 ;37(2):465-473. PMID: 28179291

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Astragaloside, Curcumin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, MicroRNA modulator, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance Synergy

[+]

Astragalus polysaccharides combined with Crataegus flavonoids may facilitate the treatment of type 1 or 2 diabetes.Apr 14, 2016

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2016 Apr 15. Epub 2016 Apr 15. PMID: 27081750

Article Published Date : Apr 14, 2016

Study Type : Animal Study

Additional Links

Substances : Astragalus, Hawthorn

Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents

Additional Keywords : Natural Substance Synergy

[+]

Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2016 Jun 6 ;190:83-90. Epub 2016 Jun 6. PMID: 27282665

Article Published Date : Jun 05, 2016

Study Type : Animal Study

Additional Links

Substances : Astragalus, Licorice

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

Article Published Date : Aug 19, 2018

Study Type : Animal Study

Additional Links

Substances : Bael , Piperine

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Bamboo extracts were found to modulate the immunostimulating effects of medicinal mushrooms.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : Int J Med Mushrooms. 2012 ;14(6):537-47. PMID: 23510247

Article Published Date : Dec 31, 2011

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bamboo, Beta-glucan, Medicinal Mushrooms

Pharmacological Actions : Immunostimulatory

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(2):e0147745. Epub 2016 Feb 16. PMID: 26881746

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Bisdemethoxycurcumin, Silymarin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Blackberry juice and quercetin together significantly reduced sodium fluoride induced oxidative and histological changes in rats.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 May 1 ;26(3):237-51. PMID: 25918918

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Blackberry, Quercetin

Diseases : Fluoride Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Cytoprotective, Hepatoprotective, Renoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Sodium Fluoride

[+]

Cannabidiol enhanced the ability of THC to inhibit cell proliferation, induce cell cycle arrest and apoptosis.Dec 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID: 20053780

Article Published Date : Dec 31, 2009

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Cancer Metastasis, Glioblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Cannabinoid Receptors, Natural Substance Synergy

[+]

Cannabidiol potentiates pharmacological effects of THC.Jan 09, 2008

Click here to read the entire abstract

Pubmed Data : Brain Res. 2008 Jan 10 ;1188:157-64. Epub 2007 Oct 12. PMID: 18021759

Article Published Date : Jan 09, 2008

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Memory Disorders

Additional Keywords : Natural Substance Synergy

[+]

Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction.Apr 19, 2017

Click here to read the entire abstract

Pubmed Data : Int J Oncol. 2017 Apr 20. Epub 2017 Apr 20. PMID: 28440400

Article Published Date : Apr 19, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carnosic Acid, Fisetin

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Chrysanthemum indicum and Cinnamomum cassia mixture may have potential as a treatment for hyperuricemia and gout.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:9764843. Epub 2017 Jul 9. PMID: 28769989

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Chrysanthemum Indicum, Cinnamon

Diseases : Gout, Hyperuricemia

Pharmacological Actions : Uricosuric Agents

Additional Keywords : Natural Substance Synergy

[+]

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2014 Jul ;8(1):260-266. Epub 2014 May 16. PMID: 24944632

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : High Fat Diet, Hyperlipidemia, Triglycerides: Elevated

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Coconut and holy basil rescued the affected mice from the disease.Feb 28, 2017

Click here to read the entire abstract

Pubmed Data : J Parasit Dis. 2017 Mar ;41(1):76-85. Epub 2016 Apr 4. PMID: 28316391

Article Published Date : Feb 28, 2017

Study Type : Animal Study

Additional Links

Substances : Coconut, Holy Basil

Diseases : Leishmaniasis

Pharmacological Actions : Immunomodulatory, Leishmanicidal

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

Colon tumors in Pirc rats were significantly reduced by 3,3'-diindolylmethane and curcumin.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2015 ;15(1):611. Epub 2015 Sep 3. PMID: 26335331

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colon Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Combination of berberine with resveratrol improves the lipid-lowering efficacy.Dec 05, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2018 Dec 6 ;19(12). Epub 2018 Dec 6. PMID: 30563192

Article Published Date : Dec 05, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine, Resveratrol

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

Additional Keywords : Natural Substance Synergy

[+]

Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice.Feb 21, 2019

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2019 Feb 22. Epub 2019 Feb 22. PMID: 30802477

Article Published Date : Feb 21, 2019

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid, Carnosine

Diseases : Diabetic Complications, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28089829

Article Published Date : Jan 11, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Capsaicin, Piceatannol , Resveratrol, Sulforaphane

Diseases : Pancreatic Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Natural Substance Synergy

[+]

Combination therapy of niacin and selenium attenuated lung injury and improved survival during sepsis. Dec 01, 2015

Click here to read the entire abstract

Pubmed Data : Crit Care Med. 2015 Dec 2. Epub 2015 Dec 2. PMID: 26646455

Article Published Date : Dec 01, 2015

Study Type : Animal Study

Additional Links

Substances : Niacin, Selenium

Diseases : Sepsis

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Natural Substance Synergy

[+]

Combination therapy using CoQ(10) and creatine may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease and Huntington Disease.Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : J Neurochem. 2009 Jun;109(5):1427-39. Epub 2009 Mar 28. PMID: 19476553

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10, Creatine

Diseases : Huntington Disease, Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Combined administration of selenium enriched green tea polysaccharides and Huo-ji polysaccharides synergistically improve immune function and decrease the oxidative stress.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : J Sci Food Agric. 2015 Jul 1. Epub 2015 Jul 1. PMID: 26130565

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Green Tea, Selenium

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Immunomodulatory, Interleukin-6 Downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy, Polysaccharides

[+]

Combined administration of vitamin C and L-carnitine could prevent the adverse effects of cisplatin on gastric tissues.Apr 19, 2018

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29677454

Article Published Date : Apr 19, 2018

Study Type : Animal Study

Additional Links

Substances : L-Carnitine, Vitamin C

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Gastroprotective

Additional Keywords : Natural Substance Synergy

[+]

Combined application of propolis and honey on the open wound healing in rats has a synergistic effect.Mar 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Med Iran. 2016 Apr ;54(4):233-9. PMID: 27309263

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Bee Propolis, Honey

Diseases : Wound Healing

Additional Keywords : bee propolis, Honey, Natural Substance Synergy, wound healing

[+]

Combined curcumin and resveratrol reduces prostate cancer incidence in mice.Jul 01, 2009

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2009 Jul 1;125(1):1-8. PMID: 19326431

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin, Resveratrol

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Natural Substance Synergy, Stilbenes

[+]

Combined pretreatment with the extract of Nardosatchys jatamansi, crocetin and selenium led to improved behavioural outcomes.Sep 30, 2012

Click here to read the entire abstract

Pubmed Data : Neurol Sci. 2012 Oct ;33(5):1011-20. Epub 2011 Dec 15. PMID: 22170092

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : Crocetin, Selenium, Spikenard

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy, Phytotherapy

[+]

Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on type 1 diabetic rats.Mar 01, 2010

Click here to read the entire abstract

Pubmed Data : Gen Physiol Biophys. 2010 Mar;29(1):23-30. PMID: 20371877

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid, Curcumin

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance Synergy

[+]

Combining curcumin with guar gum may help increase its effectiveness in treating colon cancer.Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : Drugs Aging. 2007;24(11):945-55. PMID: 20614824

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin, Guar gum

Diseases : Colon Cancer, Colorectal Cancer

Additional Keywords : Natural Substance Synergy

[+]

Combining green tea polyphenols and quercetin significantly enhanced the antiproliferative and proapoptotic effect in vivo. Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Biochem. 2014 Jan ;25(1):73-80. Epub 2013 Oct 10. PMID: 24314868

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Green Tea, Quercetin

Diseases : Prostate Cancer, Prostate Cancer: Prevention

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Bioavailability, Multidrug Resistance, Natural Substance Synergy

[+]

Compounds in oats are bioavailable and act synergistically with vitamin C enhance hamster and human LDL resistance to oxidation.Jun 01, 2004

Click here to read the entire abstract

Pubmed Data : J Nutr. 2004 Jun;134(6):1459-66. PMID: 15173412

Article Published Date : Jun 01, 2004

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Oats, Polyphenols, Vitamin C

Diseases : Cholesterol: Oxidation

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance Synergy

[+]

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Curcumin and boswellic acid induced upregulation of tumor suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila). 2015 May ;8(5):431-43. Epub 2015 Feb 23. PMID: 25712055

Article Published Date : Apr 30, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Boswellia, Curcumin

Diseases : Colorectal Cancer, Colorectal Cancer: Prevention

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, MicroRNA modulator

Additional Keywords : Natural Substance Synergy

[+]

Curcumin and capsaicin individually are protective to LDL oxidation both in vivo and in vitro, to iron-induced hepatotoxicity and to carrageenan-induced inflammation.Aug 26, 2009

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2009 Aug 26;57(16):7401-8. PMID: 16956363

Article Published Date : Aug 26, 2009

Study Type : Animal Study

Additional Links

Substances : Capsaicin, Curcumin

Diseases : Chemically-Induced Liver Damage, Cholesterol: Oxidation, Inflammation, Iron Poisoning

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Curcumin and phenethyl isothiocyanate have a synergistic inhibitory effect on the growth of human prostate xenografts. Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID: 16423986

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Phenethyl isothiocyanate

Diseases : Prostate Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Isothiocyanates, Natural Substance Synergy

[+]

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2016 Nov 16. Epub 2016 Nov 16. PMID: 27853890

Article Published Date : Nov 15, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Brain Inflammation , Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Inflammatory Agents, Brain Inflammation, CURCUMIN, Interleukin-1 beta downregulation, Natural Substance Synergy, Parkinson's disease, Piperine

[+]

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Click here to read the entire abstract

Pubmed Data : Pharmacology. 2016 Jan 30 ;97(3-4):151-160. Epub 2016 Jan 30. PMID: 26828892

Article Published Date : Jan 29, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Curcumin and resveratrol effectively prevent benzo(a)pyrene induced testicular germ cell apoptosis and restore male reproductive health.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2016 ;7:245. Epub 2016 Aug 8. PMID: 27551266

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin, Resveratrol

Pharmacological Actions : Anti-Apoptotic, Bax/Bcl2 Ratio: Decrease

Additional Keywords : Natural Substance Synergy

Problem Substances : Benzo(a)pyrene

[+]

Curcumin and resveratrol work synergistically to improve the condition of mice with lung cancer. Dec 29, 2009

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2009 Dec 29. Epub 2009 Dec 29. PMID: 20041413

Article Published Date : Dec 29, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin, Resveratrol

Diseases : Lung Cancer

Additional Keywords : Natural Substance Synergy

[+]

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lipids Health Dis. 2015 ;14(1):100. Epub 2015 Sep 3. PMID: 26335572

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Gallstones, High Fat Diet

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

[+]

Curcumin in combination with EPA and DHA work synergistically to reduce inflammation. Feb 01, 2010

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8. PMID: 19744468

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin, DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid)

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants

Additional Keywords : Natural Substance Synergy

[+]

Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own. Jul 25, 2015

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2015 Jul 26 ;40(2):445-452. Epub 2015 Jul 26. PMID: 26278679

Article Published Date : Jul 25, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Liver Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Curcumin might increase the effect of vitamin C in protecting the function of endothelial cells through its anti-oxidant with hypoglycemic and hypolipidemic actions.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Clin Hemorheol Microcirc. 2006;35(4):481-9. PMID: 17148847

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin, Vitamin C

Diseases : Dyslipidemias, Endothelial Dysfunction

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Natural Substance Synergy

[+]

Curcumin synergistically increases effects of beta-interferon and retinoic acid on breast cancer cells in vitro and in vivo.Sep 27, 2016

Click here to read the entire abstract

Pubmed Data : J Drug Target. 2016 Sep 28:1-23. Epub 2016 Sep 28. PMID: 27677346

Article Published Date : Sep 27, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Curcumin, resveratrol, and EGCG, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors.Feb 15, 2018

Click here to read the entire abstract

Pubmed Data : Cancer Immunol Immunother. 2018 Feb 16. Epub 2018 Feb 16. PMID: 29453519

Article Published Date : Feb 15, 2018

Study Type : Animal Study

Additional Links

Substances : Curcumin, EGCG (Epigallocatechin gallate), Resveratrol

Diseases : Head and Neck Cancer, Human Papillomavirus (HPV)

Pharmacological Actions : Immunomodulatory

Additional Keywords : Natural Substance Synergy

[+]

Curcumin-manganese complexes have enhanced antioxidant activity. Dec 15, 2003

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2003 Dec 15;35(12):1632-44. PMID: 14680686

Article Published Date : Dec 15, 2003

Study Type : Animal Study

Additional Links

Substances : Curcumin, Manganese

Diseases : Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic mice.Aug 06, 2008

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Pubmed Data : Forensic Sci Int. 2008 Aug 6;179(2-3):e25-9. Epub 2008 Jun 6. PMID: 17715888

Article Published Date : Aug 06, 2008

Study Type : Animal Study

Additional Links

Substances : Fish Oil, Fucoxanthin

Diseases : Diabetes Mellitus: Type 2, Obesity

Additional Keywords : Natural Substance Synergy

[+]

Drinking green tea may reduce the toxic potential of acute high oral doses of EGCG supplementation. Jan 31, 2015

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Pubmed Data : Food Chem Toxicol. 2015 Feb ;76:103-8. Epub 2014 Dec 17. PMID: 25528115

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Green Tea

Pharmacological Actions : Hepatoprotective

Additional Keywords : Bioavailability, Natural Substance Synergy, Supplementation

[+]

Effect of fermented Spirulina maxima extract on cognitive-enhancing activities in mice with scopolamine-induced dementia.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:7218504. Epub 2018 Nov 26. PMID: 30598686

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Fermented Foods and Beverages, Spirulina

Diseases : Dementia

Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.Dec 31, 2017

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Pubmed Data : Future Microbiol. 2018 09 ;13:1375-1382. Epub 2018 Sep 26. PMID: 30256168

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Pea Protein

Diseases : Candida Albicans, Candidiasis: Vulvovaginal

Pharmacological Actions : Antifungal Agents

Additional Keywords : Natural Substance Synergy

[+]

Effects of puerarin on the pharmacokinetics of triptolide in rats.Nov 30, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2019 Dec ;57(1):407-411. PMID: 31230510

Article Published Date : Nov 30, 2019

Study Type : Animal Study

Additional Links

Substances : Puerarin, Triptolide

Additional Keywords : Natural Substance Synergy

[+]

EGCG can be used as an enhanced supplement for huperzine A to treat Alzheimer's disease.Aug 01, 2009

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Pubmed Data : Nutr Neurosci. 2009 Aug;12(4):142-8. PMID: 19622237

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Catechin , Huperzine

Diseases : Alzheimer's Disease

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin.Mar 31, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2011 Apr ;32(4):561-7. Epub 2011 Jan 27. PMID: 21273642

Article Published Date : Mar 31, 2011

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol, Silibinin

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Eriodictyol synergistically potentiates the anti-tumour effect of EGCG by amplifying 67LR-dependent signalling in MM cellsDec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2015 ;5:9474. Epub 2015 Mar 31. PMID: 25824377

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Eriodictyol, Yerba Santa

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Bioenhancer, EGCG Sensitizer, Natural Substance Synergy

[+]

Essential oil S. aromaticum and ethanolic extract R. officinalis could be useful in combination with ketorolac for the treatment of inflammatory pain.Sep 30, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Oct ;94:858-864. Epub 2017 Aug 10. PMID: 28802239

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Clove, Rosemary

Diseases : Inflammation

Pharmacological Actions : Antinoceceptive

Additional Keywords : Natural Substance Synergy

[+]

Ferulic acid enhances the vasorelaxant properties of EGCG in TNF-α-induced inflammatory aorta.Jun 30, 2014

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2014 Jul ;25(7):807-14. Epub 2014 Apr 4. PMID: 24794014

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Ferulic acid

Diseases : Inflammation

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vasodilator Agents

Additional Keywords : Natural Substance Synergy

[+]

Ginkgo biloba and red clover in combination was more effective as protective agents compared to each one of them alone.Jul 31, 2016

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2016 Aug ;94:112-27. Epub 2016 May 24. PMID: 27234133

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba, Red Clover

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents, Prophylactic Agents

Additional Keywords : Natural Substance Synergy

Problem Substances : Arsenite

[+]

Glutamine enhances the gut-trophic effects of growth hormone in rat after massive small bowel resection.Jan 01, 1986

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Pubmed Data : Arch Dermatol Res. 1986;278(6):433-6. PMID: 11421603

Article Published Date : Jan 01, 1986

Study Type : Animal Study

Additional Links

Substances : Glutamine

Diseases : Bowel Surgery

Additional Keywords : Natural Substance Synergy

[+]

Glycosaminoglycans co-administration enhance insulin-like growth factor-I neuroprotective and neuroregenerative activity in traumatic and genetic models of motor neuron disease.Jul 01, 2000

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Pubmed Data : Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):339-46. PMID: 10817918

Article Published Date : Jul 01, 2000

Study Type : Animal Study

Additional Links

Substances : Glycoaminoglycans, Insulin-like Growth Factor (IGF-1)

Diseases : Amyotrophic Lateral Sclerosis, Motor Neuron Disease

Pharmacological Actions : Neuroprotective Agents, Neurorestorative

Additional Keywords : Natural Substance Synergy

[+]

Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats.May 20, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Higenamine enhances the antitumor effects of cucurbitacin B in breast cancer.Sep 30, 2018

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2018 Oct ;40(4):2127-2136. Epub 2018 Aug 6. PMID: 30106443

Article Published Date : Sep 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Natural Substance Synergy

[+]

Hypericin, a compound found within St. John's wort, in combination with photodynamic therapy induces cell death in nasopharyngeal cancer. Nov 01, 2003

Click here to read the entire abstract

Pubmed Data : Int J Oncol. 2003 Nov;23(5):1401-5. PMID: 14532982

Article Published Date : Nov 01, 2003

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Nasopharyngeal Cancer

Therapeutic Actions : Light Therapy

Pharmacological Actions : Anti-Tumor, Antioxidants, Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Kaempferol and chrysin have synergistic effects to improve septic mice survival.Jan 05, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Jan 6 ;22(1). Epub 2017 Jan 6. PMID: 28067837

Article Published Date : Jan 05, 2017

Study Type : Animal Study

Additional Links

Substances : Chrysin, Kaempferol

Diseases : Sepsis

Additional Keywords : Natural Substance Synergy

[+]

L-arginine augments the antioxidant effect of garlic against acetic acid-induced ulcerative colitis in rats.Oct 01, 2009

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2009 Oct;22(4):373-80. PMID: 19783514

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine, Garlic

Diseases : Ulcerative Colitis

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance Synergy, Plant Extracts

[+]

Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats.Jun 23, 2006

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Pubmed Data : J Biol Chem. 2006 Jun 23;281(25):17359-68. Epub 2006 Apr 17. PMID: 20804619

Article Published Date : Jun 23, 2006

Study Type : Animal Study

Additional Links

Substances : Lotus , Taurine

Diseases : Obesity

Additional Keywords : Natural Substance Synergy

[+]

Mechanism of antidiabetic and synergistic effects of ginseng polysaccharide and ginsenoside Rb1 on diabetic rat model.Sep 04, 2018

Click here to read the entire abstract

Pubmed Data : J Pharm Biomed Anal. 2018 Sep 5 ;158:451-460. Epub 2018 Jun 18. PMID: 30032757

Article Published Date : Sep 04, 2018

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Hypoglycemia

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance Synergy, Polysaccharides

[+]

Monotherapy with oligonol showed a superior anti-inflammatory efficacy as compared to quantum light and acupuncture monotherapies.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:687196. Epub 2015 May 3. PMID: 26064171

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lychee

Diseases : Inflammation

Therapeutic Actions : Acupuncture, Light Therapy

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Acupuncture, Anti-Inflammatory Agents, light therapy, Lychee, Natural Substance Synergy

[+]

NAC and myo-inositol work synergistically to prevent lung tumor formation in a mouse model. Sep 01, 2002

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2002 Sep;23(9):1455-61. PMID: 12189187

Article Published Date : Sep 01, 2002

Study Type : Animal Study

Additional Links

Substances : Myo-inositol, NAC (N-acetyl-L-cysteine)

Diseases : Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Chemopreventive

Additional Keywords : Isothiocyanates, Natural Substance Synergy

[+]

Nanozeolites and artichoke leaf extract has the synergetic effect on increasing the urinary excretion of nicotine.Nov 28, 2012

Click here to read the entire abstract

Pubmed Data : Arzneimittelforschung. 2012 Nov 29. Epub 2012 Nov 29. PMID: 23196970

Article Published Date : Nov 28, 2012

Study Type : Animal Study

Additional Links

Substances : Artichoke, Zeolite

Diseases : Nicotine/Tobacco Toxicity

Pharmacological Actions : Detoxifier

Additional Keywords : Natural Substance Synergy

Problem Substances : Nicotine

[+]

OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property with higher cytoprotective effects and antioxidant activities.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2015;2015:318125. Epub 2015 Jun 9. PMID: 26180582

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa , Olive leaf extract

Diseases : Hypertension, Oxidative Stress

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardiovascular Agents, Cytoprotective, Vasodilator Agents

Additional Keywords : Dose Response, Natural Substance Synergy, Plant Extracts

[+]

P.cuspidatum extract suppressed NF-κB signaling pathway and exerts its anti-colitis effects via synergistic effects of polydatin, resveratrol or emodin.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2018 ;9:347. Epub 2018 Apr 11. PMID: 29695964

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Emodin, Hu Zhang (Polygonum cuspidatum), Resveratrol

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Paeoniflorin and astragaloside IV alleviate ischemic brain edema.Aug 31, 2017

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2017 Sep ;31(9):1410-1418. Epub 2017 Jul 28. PMID: 28752625

Article Published Date : Aug 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astragaloside, Paeoniflorin

Diseases : Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 ;46(sup3):S931-S942. Epub 2018 Oct 11. PMID: 30307334

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides, Parthenolide

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Piperine enhanced the bioavailability of curcumin and potentiated its protective effects against CUS induced cognitive impairment and associated oxidative damage in mice.Dec 06, 2012

Click here to read the entire abstract

Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Piperine enhances the antioxidant and anti-Inflammatory activities of thymoquinone against microcystin-LR-induced hepatotoxicity and neurotoxicity.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:1309175. Epub 2019 Apr 16. PMID: 31178949

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Piperine, Thymoquinone

Diseases : Bacterial Infections

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

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View the Evidence: 401 Abstracts with Natural Substance Synergy Research

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A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Dec 31, 2011

A combination of curcumin and fennel essential oil significantly improved symptoms and quality of life in IBS patients over 30 days.May 31, 2016

A combination of green tea and ginkgo biloba extracts effectively improved skin conditions and the improvement of skin elasticity.Aug 31, 2014

A combination of selenium and silymari led to a significant reduction in PSA levels.Dec 14, 2013

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

A herbal formulation is a safe and effective intervention for management of joint discomfort.Apr 30, 2018

A joint consumption of apple juice, natural antioxidants and polyphenols might provide mild favorable effects on cardiometabolic markers, as compared to apple polyphenols alone.Nov 30, 2014

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

Coenzyme Q10 and vitamin E had beneficial effects on cardiometabolic outcomes among women with polycystic ovary syndrome.Jan 31, 2019

Constitutes of Boswellia serrata extract act synergistically to exert anti-inflammatory/anti-arthritic activity.Mar 05, 2019

CoQ10 and vitamin E supplementation had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels.Sep 06, 2018

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Gazpacho soup consumption is associated with a lower prevalence of hypertension.Sep 30, 2013

Increased dietary ω-3 polyunsaturated fatty acids and extra virgin olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS.May 31, 2015

Magnesium sulphate increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.Nov 20, 2016

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.Jan 01, 2009

Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.Oct 31, 2009

Study suggests link between tea consumption and vitamin D levelsAug 19, 2012

The administration of cranberries, L. rhamnosus, and vitamin C might represent a safe and effective option in women with recurrent UTIs.Jun 06, 2016

The combination hazelnut and cocoa may act in a synergic and protective way on cardiovascular system.Jul 08, 2017

The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.Mar 31, 2015

The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of homocysteine.Dec 31, 2014

The consumption of cooked whole eggs is an effective way to increase the absorption of α-tocopherol and γ-tocopherol from foods.Oct 31, 2016

The consumption of nuts is associated with better dietary and lifestyle patterns in Polish adults.Jun 21, 2019

The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancersNov 30, 2014

There is a synergistic interplay between curcumin and polyphenol-rich foods in the Mediterranean diet.Jul 20, 2017

These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.Jun 25, 2019

Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with osteoarthritis.Jan 08, 2018

Zinc and the Chinese herbal formula Jinye Baidu granule significantly increase the negative conversion rate of HCMV-IgM.May 01, 2005

ω-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.May 31, 2017

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma.Oct 05, 2015

Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.Aug 31, 2015

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.May 08, 2012

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

The synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells was cytostatic, not cytotoxic.Dec 31, 2012

γ-tocotrienol and 6-gingerol when used in combination act synergistically increasing cytotoxicity and apoptosis in cancer cells.Dec 31, 2014

Irvingia gabonensis extract has an analgesic effect.Jun 01, 2009

A combination of black bean peel and pomegranate peel extracts, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress induced damage to the pancreas.Dec 31, 2014

A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.Jan 31, 2015

A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.Sep 01, 2016

A combination of five main alkaloids from Rhizoma Coptidis showed a synergetic cholesterol-lowering efficacy.Apr 14, 2016

A combination of lycopene and vitamin E acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies.Dec 31, 2016

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

A combination of pomegranate, date fruit and date seeds led to a more potent treatment result than each alone. Mar 25, 2015

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.Feb 06, 2017

A curcumin-artemisinin combination is effective for malaria. May 01, 2006

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.Dec 31, 2016

A sea buckthorn and olive oil mixture could be considered as an alternative dressing for full-thickness burns.Jun 30, 2014

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria.Feb 29, 2012

ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with AI or CL alone.Jul 22, 2015

Administration of melatonin and vitamin C as radioprotectors before irradiation may reduce genotoxicity caused by x-ray irradiation.Dec 31, 2015

Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.Dec 31, 2010

Amelioration of oxidative stress by dietary fenugreek seeds is potentiated by onion in streptozotocin-induced diabetic rats.Mar 19, 2017

Andrographis and Hedyotis corymbosa in combination with curcumin have anti-malaria action.Feb 01, 2004

Antioxidants exhibited protective effects against D-galactose-induced oxidative damage in rats.Mar 29, 2016

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Apple polyphenol extracts might emerge as a promising nutritional ingredient in the management of chronic diseases such as diabetes.Dec 31, 2015

Artemisinin and curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity.Jun 30, 2014

Artificial tears containing epigallocatechin gallate and hyaluronic acid had a synergistic effect in the treatment of dry eye syndrome.Dec 31, 2015

Astaxanthin reduces the susceptibility to oxidation and potentizes the immunomodulatory properties of fish oil. Oct 05, 2011

Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.Dec 31, 2016

Astragalus polysaccharides combined with Crataegus flavonoids may facilitate the treatment of type 1 or 2 diabetes.Apr 14, 2016

Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Bamboo extracts were found to modulate the immunostimulating effects of medicinal mushrooms.Dec 31, 2011

Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.Dec 31, 2015

Blackberry juice and quercetin together significantly reduced sodium fluoride induced oxidative and histological changes in rats.Apr 30, 2015

Natural Substance Synergy

View the Evidence:
401 Abstracts with Natural Substance Synergy Research