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Natural Substance Synergy
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14 Problem Substances Researched for Natural Substance Synergy
Name
AC
CK
Focus
Aluminum Chloride
2
4
Benzo(a)pyrene
2
4
Sodium Fluoride
2
4
Acetaminophen
1
2
Aflatoxin
1
2
Alloxan
1
2
Arsenite
1
2
Concanavalin A
1
2
Monosodium Glutamate (MSG)
1
2
Mycotoxin
1
2
Nicotine
1
2
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
1
2
Paracetamol
1
2
Antibiotics
1
1
202 Diseases Researched for Natural Substance Synergy
Name
AC
CK
Focus
Oxidative Stress
35
65
Breast Cancer
34
49
Prostate Cancer
26
32
Inflammation
18
26
Cardiovascular Diseases
6
25
Lung Cancer
16
24
Osteoarthritis: Knee
3
21
C-Reactive Protein
2
20
Hyperlipidemia
6
20
Cognitive Decline/Dysfunction
6
19
Colon Cancer
17
19
Colorectal Cancer
9
19
Diabetic Complications
8
18
Breast Cancer: Triple Negative
9
17
Liver Cancer
11
17
Cervical Cancer
6
16
Cancers: All
12
14
Diabetes Mellitus: Type 2
8
14
Hypertension
3
14
Atherosclerosis
2
12
Cardiovascular Disease: Prevention
2
12
Hypercholesterolemia
2
12
Metabolic Diseases
2
12
Obesity
7
12
Vitamin D Deficiency
2
12
Alzheimer's Disease
8
11
Hyperglycemia
4
11
Aging Skin
1
10
Cholesterol: High
1
10
Cytomegalovirus Infections
1
10
Esophageal Cancer
1
10
Fibrosarcoma
1
10
Folic Acid/Folate Deficiency
1
10
Headache: Migraine
1
10
Herpes Simplex Virus Type 1
1
10
High Cholesterol
1
10
Homocysteine: Elevated
1
10
Irritable Bowel Syndrome
1
10
Morphine Tolerance/Dependence
1
10
Neurofibromatosis
1
10
Osteoarthritis
1
10
Polycystic Ovary Syndrome
1
10
Prostate: PSA Doubling
1
10
Prostatic Hyperplasia
1
10
Smoking Cessation: Nicotine Addiction
1
10
Urinary Tract Infections
1
10
Chemically-Induced Liver Damage
5
9
Lipid Peroxidation
5
9
Melanoma
7
9
Brain Inflammation
4
8
Diabetes: Oxidative Stress
4
8
Multiple Myeloma
3
8
Myocardial Infarction
4
8
Parkinson's Disease
5
8
Insulin Resistance
4
7
Neurodegenerative Diseases
5
7
Pancreatic Cancer
6
7
Acute Myeloid Leukemia
5
6
High Fat Diet
3
6
Promyelocytic leukemia
6
6
Sepsis
3
6
Wound Healing
3
6
Cancers: Drug Resistant
1
5
Cancers: Multi-Drug Resistant
1
5
Escherichia coli Infections
5
5
Head and Neck Cancer
3
5
Leukemia: Chronic myelogenous leukemia (CML)
1
5
Malaria
3
5
Oral Cancer
5
5
Staphylococcus aureus infection
5
5
Aluminum Toxicity
2
4
Cadmium Poisoning
2
4
Cancer Metastasis
2
4
Cerebral Ischemia
2
4
Cholestasis
2
4
Cholesterol: Oxidation
2
4
Diabetes Mellitus: Type 1
2
4
Dyslipidemias
2
4
Endothelial Dysfunction
2
4
Fluoride Toxicity
2
4
Gastric Cancer
4
4
Glioblastoma
3
4
Hypoglycemia
3
4
Liver Fibrosis
2
4
Prostate Cancer: Prevention
3
4
Triglycerides: Elevated
2
4
Ulcerative Colitis
2
4
Brain Ischemia
2
3
Candida Albicans
2
3
Carcinoma: Non-Small-Cell Lung
2
3
Chronic Pain
2
3
Colon Cancer: Prevention
2
3
Colorectal Cancer: Prevention
2
3
DNA damage
2
3
Dementia
2
3
Human Papillomavirus (HPV)
2
3
Lipopolysaccharide-Induced Toxicity
3
3
Listeria Infections
3
3
Nonalcoholic fatty liver disease (NAFLD)
2
3
Osteoporosis
2
3
Squamous cell carcinoma
3
3
Staphylococcus aureus: Methicillin-resistant (MRSA)
3
3
Acetaminophen (Tylenol) Toxicity
1
2
Aging: Heart
1
2
Amyotrophic Lateral Sclerosis
1
2
Androgen-Induced Diseases
1
2
Arteriosclerosis
1
2
Avian Influenza
1
2
Bacterial Infections
1
2
Bowel Surgery
1
2
Brain Cancer
1
2
Breast Cancer: Chemically-Induced
2
2
Burns
1
2
Cancers
2
2
Candidiasis: Vulvovaginal
1
2
Chemotherapy and Radiation Toxicity
1
2
Chemotherapy-Induced Toxicity: Cyclophosphamide
1
2
Chemotherapy-Induced Toxicity: Cisplatin
1
2
Chemotherapy-Induced Toxicity: Gentamicin
1
2
Chronic Myeloid Leukemia
1
2
Depressive Disorder
1
2
Diabetes
1
2
Diabetic Neuropathy
1
2
Dry Eye Syndromes
1
2
Emesis
1
2
Fructose-Induced Toxicity
1
2
Gallstones
1
2
Gout
1
2
Heart Failure
1
2
Hepatitis C
1
2
Huntington Disease
1
2
Hyperalgesia
1
2
Hyperinsulinism
1
2
Hyperuricemia
1
2
Immune Dysregulation: TH1/TH2 imbalance
1
2
Influenza A
1
2
Iron Poisoning
1
2
Leishmaniasis
1
2
Leukemia
2
2
Leukemia: Chronic Lymphocytic Leukemia (CLL)
2
2
Liver Cancer: Prevention
1
2
Liver Cirrhosis
1
2
Liver Damage
1
2
Liver Damage: Aflatoxin-Induced
1
2
Liver Damage: Drug-Induced
1
2
Liver Disease
1
2
Malignant Melanoma
1
2
Memory Disorders
1
2
Menopausal Syndrome
1
2
Motor Neuron Disease
1
2
Multiple Sclerosis
2
2
Myelotoxicity
1
2
Nasopharyngeal Cancer
1
2
Nicotine/Tobacco Toxicity
1
2
Peripheral Neuropathies
1
2
Salmonella Infections
2
2
Skin Cancer: Prevention
1
2
Stress
1
2
Ulcers
1
2
Vomiting
1
2
Abdominal Obesity (Midsection Fat)
1
1
Acinetobacter baumannii infection
1
1
Acute T cell Leukemias
1
1
Aging: Brain
1
1
Arthritis
1
1
Autoimmune Diseases
1
1
Bacillus Cereus infection
1
1
Brain Injury: Hippocampal Damage
1
1
Cancer Stem Cells
1
1
Candida Infection
1
1
Chagas Disease
1
1
Chemotherapy-Induced Toxicity: Doxorubicin
1
1
Chronic Lymphocytic Leukemia
1
1
Dental Implantation
1
1
Encephalomyelitis
1
1
Endometrial Cancer
1
1
Food Poisoning
1
1
Gastrointestinal Inflammation
1
1
Gonorrhea
1
1
Gram-Positive Bacterial Infections
1
1
Kidney Cancer
1
1
Learning disorders
1
1
Leiomyosarcoma
1
1
Leukemia: Acute myelogenous leukemia (AML)
1
1
Leukemia: Acute promyelocytic leukemia
1
1
Lymphoma
1
1
Micrococcus luteus infections
1
1
Neuroblastoma
1
1
Neurodevelopmental Disorders
1
1
Neurologic Disorders
1
1
Neurological Conditions
1
1
Non-Small-Cell Lung Carcinoma
1
1
Osteoclastoma
1
1
Osteopenia
1
1
Ovarian Cancer
1
1
Periodontitis
1
1
Photooxidative Stress
1
1
Pseudomonas aeruginosa
1
1
Renal Cancer
1
1
Rotavirus Infections
1
1
Skin Cancer
1
1
Tongue Cancer
1
1
1 Problematic Actions Researched for Natural Substance Synergy
Name
AC
CK
Focus
Radiotherapy
1
2
341 Substances Researched for Natural Substance Synergy
Name
AC
CK
Focus
Curcumin
75
150
Vitamin C
27
67
Resveratrol
32
52
Green Tea
15
50
Quercetin
30
49
Polyphenols
16
46
EGCG (Epigallocatechin gallate)
25
37
Vitamin D
25
34
Vitamin E
16
33
Frankincense
4
31
Omega-3 Fatty Acids
3
30
Turmeric
9
30
Vitamin B-12
3
30
Piperine
16
29
Selenium
12
27
Vitamin E: alpha tocopherol
6
27
Fish Oil
5
25
Ginkgo biloba
3
22
Catechin
13
20
Folic Acid
2
20
Lignans
2
20
Anthocyanins
7
19
Coenzyme Q10
4
16
Nigella sativa (aka Black Seed)
4
16
Olive Oil
4
15
Melatonin
11
14
Zinc
4
14
Black Pepper
3
13
EPA (Eicosapentaenoic Acid)
3
13
Luteolin
8
12
Riboflavin (Vitamin B-2)
3
12
Tocotrienol: Gamma
4
12
Cocoa
2
11
Cranberry
2
11
Cyanidin 3-glucoside
2
11
Milk Thistle
2
11
Vitamin E: Gamma-Tocopherol
2
11
Aloe Vera
1
10
Angelica
1
10
Apples
1
10
Chinese Herbal Formula: Jinye Baidu
1
10
Delphinidin
1
10
Egg
1
10
Fennel
1
10
Garlic
6
10
Haritaki (Terminalia chebula)
1
10
Hazelnut
1
10
Lactobacillus rhamnosus
1
10
Magnesium Sulfate
1
10
Mangosteen
1
10
NAC (N-acetyl-L-cysteine)
5
10
Nattokinase
1
10
Phosphatidylserine
1
10
Pine Cone
1
10
Pycnogenol (Pine Bark)
1
10
Red Yeast Rice
1
10
Soup
1
10
Thymoquinone
5
10
Vitamin B-5 (Pantothenic Acid)
1
10
acetyl-11-keto-beta-boswellic acid
1
10
Astragaloside
6
9
Fisetin
4
9
Flavonoids
7
9
Sulforaphane
8
9
Berberine
7
8
Cannabidiol
4
8
Delta-tetrahydrocannabinol (THC)
4
8
Ferulic acid
5
8
Artemisinin
5
7
Cucurbitacin B
2
7
Ginsenosides
4
7
Lycopene
4
7
Silibinin
5
7
Capsaicin
4
6
Fenugreek
3
6
Genistein
6
6
Pomegranate
4
6
Spirulina
3
6
Achiote
1
5
Alpha-Lipoic Acid
3
5
Amurensin G
1
5
Carnosic Acid
4
5
Chrysin
4
5
Citral
1
5
Gingerol
1
5
Ginseng
1
5
Grape Seed Extract
4
5
Hesperidin
3
5
Honey
3
5
Lemongrass
1
5
Lotus
3
5
Panaxadiol
1
5
Pterostilbene
4
5
Rosemary
3
5
Sesamin
1
5
Vitamin K
5
5
Apple Polyphenols
2
4
Arginine
2
4
Astragalus
2
4
Black Tea
2
4
Blackberry
2
4
Blueberry
3
4
Carotenoids
4
4
Cinnamon
3
4
Emodin
2
4
Ginger
4
4
Kaempferol
3
4
Onion
2
4
Oregano
3
4
Phenethyl isothiocyanate
3
4
Piceatannol
3
4
Puerarin
2
4
Red Clover
2
4
Red Sage
2
4
Reishi Mushroom
3
4
Sea buckthorn
3
4
Soy Protein
2
4
Tangeretin
3
4
Vitamin A
3
4
Artichoke
2
3
Astaxanthin
2
3
Beans: All
2
3
Bee Propolis
2
3
Cannabis
2
3
Chinese Skullcap
2
3
Citrus Peel
2
3
Clove
2
3
DHA (Docosahexaenoic Acid)
2
3
Fucoidan
2
3
Indole-3-Carbinol
2
3
Isoflavones
2
3
Isothiocyanates
3
3
Licorice
2
3
Medicinal Mushrooms
2
3
Mistletoe
2
3
Mugwort
2
3
Nobiletin
2
3
Olive
2
3
Silymarin
2
3
St. Johns Wort
2
3
Thyme
2
3
Tomato
3
3
Acai
2
2
Adlay
1
2
Andrographis
1
2
Arctigenin
2
2
Asiatic Acid
1
2
Bael
1
2
Baicalein
2
2
Bamboo
1
2
Bee Venom
2
2
Beta-glucan
1
2
Bisdemethoxycurcumin
1
2
Black Bean
1
2
Boswellia
1
2
Broccoli
2
2
Bromelain
2
2
Cannabinoids
1
2
Carnosine
1
2
Chamomile
1
2
Chlorogenic Acid
1
2
Chokeberry
2
2
Chrysanthemum Indicum
1
2
Coconut
1
2
Coptidis rhizoma
1
2
Creatine
1
2
Crocetin
1
2
Cumin
2
2
Daidzein
2
2
Dates
1
2
Eriodictyol
1
2
Fermented Foods and Beverages
1
2
Fruit: All
2
2
Fucoxanthin
1
2
Gardenia
1
2
Ginseng (Korean)
1
2
Glutamine
1
2
Glutathione
1
2
Glycoaminoglycans
1
2
Glycyrrhizin
1
2
Graviola
1
2
Guar gum
1
2
Hawthorn
1
2
Hedyotis corymbosa
1
2
Hibiscus sabdariffa
1
2
Holy Basil
1
2
Honokiol
2
2
Hu Zhang (Polygonum cuspidatum)
1
2
Huperzine
1
2
Insulin-like Growth Factor (IGF-1)
1
2
Irvingia gabonensis
1
2
Kahweol
2
2
Kudzu
1
2
L-Carnitine
1
2
Lemon
1
2
Ligustrazine
1
2
Lion's Mane (Hericium Erinaceus)
1
2
Loquat
1
2
Lupeol
1
2
Lychee
1
2
Manganese
1
2
Marjoram
1
2
Mint
1
2
Myo-inositol
1
2
Niacin
1
2
Oats
1
2
Oleanolic acid
1
2
Olive leaf extract
1
2
Paeoniflorin
1
2
Parthenolide
1
2
Pea Protein
1
2
Peanut
1
2
Piperlongumine
2
2
Polyunsaturated Fatty Acids (PUFAs)
2
2
Pomegranate Peel
1
2
Pumpkin
1
2
Purple Carrots
1
2
Rhubarb
1
2
Rose Hips
2
2
Rutin
2
2
Sage
2
2
Shiitake Mushroom
1
2
Spikenard
1
2
Tamarind
1
2
Taurine
1
2
Ursolic Acid
2
2
Vitamin K2
1
2
Water: Deuterium Depleted
1
2
Yerba Santa
1
2
Zeolite
1
2
Acerola
1
1
Anise
1
1
Antioxidant formulas
1
1
Apigenin
1
1
Apple
1
1
Bai Zhu
1
1
Bay leaf
1
1
Beet
1
1
Benzyl isothiocyanate
1
1
Berries: All
1
1
Beta Sitosterol
1
1
Beta-Caryophyllene
1
1
Beta-Elemene
1
1
Betulinic acid
1
1
Black Currant
1
1
Black Tea Theaflavins
1
1
Burdock
1
1
Butyrate
1
1
Caffeine
1
1
Caffeoylquinic Acids
1
1
Camu Camu
1
1
Cardamom
1
1
Carnosine
1
1
Carsonic Acid
1
1
Carvacrol
1
1
Cherry: All Varieties
1
1
Chitosan
1
1
Chlorella (Algae)
1
1
Coffee
1
1
Copper
1
1
Cordyceps Militaris
1
1
Coriandor
1
1
Cranberry Proanthocyanidins
1
1
Cryptoxanthin
1
1
Culinary Herbs and Spices
1
1
Curcuma Longa
1
1
D-Limonene
1
1
Dandelion
1
1
Diallyl sulfide
1
1
Diosgenin
1
1
Ellagic Acid
1
1
Eugenol
1
1
Evodiamine
1
1
Fig
1
1
Garcinia dulcis
1
1
Gold (nanoparticles)
1
1
Grapes
1
1
Guava
1
1
Hydrogen Peroxide
1
1
Inositol Hexaphosphate
1
1
Kimchi
1
1
Lactobacillus casei
1
1
Lactobacillus rhamnosus GG
1
1
Lavender: Essential Oil
1
1
Lecithin
1
1
Lettuce
1
1
Lingonberry
1
1
Long Pepper
1
1
Lutein
1
1
Magnolol
1
1
Maitake Mushroom
1
1
Mango
1
1
Milk
1
1
Modified Arabinoxylan Rice Bran (MGN-3)
1
1
Modified Citrus Pectin
1
1
Modified Rice Bran (MGN-3)
1
1
Monolaurin
1
1
Mulberry
1
1
Mustard Oil
1
1
Myricetin
1
1
Naringenin
1
1
Nettle
1
1
Nisin
1
1
Noni
1
1
Onions
1
1
Orange: Mandarin
1
1
Oridonin
1
1
Palmitoylethanolamide
1
1
Papain
1
1
Plum
1
1
Potassium
1
1
Psychedelics:All
1
1
Raspberry
1
1
Rice Bran
1
1
Rooibos
1
1
Rose
1
1
S-Adenosylmethionine (SAMe)
1
1
Saffron
1
1
Stilbenes
1
1
Strawberry
1
1
Tea
1
1
Testosterone
1
1
Theaflavins
1
1
Thiamine (B-1)
1
1
Thujae occidentalis
1
1
Toad
1
1
Tocopherols
1
1
Tocotrienol: Delta
1
1
Tomatidine
1
1
Ubiquinol
1
1
Vanadium
1
1
Vegetables: All
1
1
Vitamin E: Gamma-tocotrienol
1
1
Vitamin E: delta-tocopherol
1
1
Walnut
1
1
Water: Deep Sea
1
1
Watercress
1
1
Whey
1
1
Yeast
1
1
Zataria multiflora
1
1
beta-Carotene
1
1
5 Therapeutic Actions Researched for Natural Substance Synergy
Name
AC
CK
Focus
Aromatherapy
1
10
Mediterranean diet
1
10
Light Therapy
2
4
Acupuncture
1
2
Exercise: Endurance
1
2
111 Pharmacological Actions Researched for Natural Substance Synergy
Name
AC
CK
Focus
Apoptotic
96
148
Antioxidants
77
143
Antiproliferative
91
135
Anti-Inflammatory Agents
39
112
Neuroprotective Agents
34
66
Antineoplastic Agents
21
46
Chemopreventive
30
44
Anticholesteremic Agents
7
38
Cell cycle arrest
25
38
Tumor Necrosis Factor (TNF) Alpha Inhibitor
15
37
Anticarcinogenic Agents
18
34
Hepatoprotective
18
34
Interleukin-6 Downregulation
13
33
Hypoglycemic Agents
13
31
Antihypertensive Agents
5
26
Hypolipidemic
9
26
NF-kappaB Inhibitor
20
26
Cardioprotective
10
25
Antiviral Agents
4
23
Interleukin-1 beta downregulation
7
20
Chemotherapeutic
7
19
Immunomodulatory
10
19
Chemosensitizer
9
18
Nrf2 activation
7
18
Analgesics
4
15
Cyclooxygenase 2 Inhibitors
13
15
Tumor Suppressor Protein p53 Upregulation
8
13
Anti-metastatic
9
11
Anti-Bacterial Agents
9
10
Anti-Infective Agents
1
10
Dermatologic Agents
1
10
Vascular Cell Adhesion Molecule-1 Inhibitor
1
10
Angiogenesis Inhibitors
5
9
Anti-Apoptotic
4
8
Antimicrobial
8
8
Renoprotective
4
8
Vascular Endothelial Growth Factor Inhibitors
4
8
Antinoceceptive
4
7
Chemoprotective Agents
4
7
Anti-Fibrotic
3
6
Anti-Tumor
3
6
Matrix metalloproteinase-2 (MMP-2) inhibitor
4
6
MicroRNA modulator
4
6
Vasodilator Agents
3
6
Bcl-2 protein down-regulation
5
5
Matrix metalloproteinase-9 (MMP-9) inhibitor
4
5
Cytoprotective
2
4
Cytotoxic
3
4
Interleukin-8 downregulation
3
4
Superoxide Dismutase Up-regulation
2
4
Vascular Endothelial Growth Factor A Inhibitor
3
4
Alpha-amylase inhibitor
2
3
Caspase-3 Activation
3
3
Gastroprotective
2
3
Heme oxygenase-1 up-regulation
2
3
Acetylcholinesterase Inhibitor
1
2
Anti-Adipogenic
2
2
Anti-Angiogenic
1
2
Anti-Ulcer Agents
1
2
Anti-atherogenic
1
2
Antidepressive Agents
1
2
Antifungal Agents
1
2
Antioxidant
1
2
Autophagy Up-regulation
2
2
Bax/Bcl2 Ratio: Decrease
1
2
Bone Density Conservation Agents
1
2
Brain-derived neurotrophic factor modulator
1
2
Cardiovascular Agents
1
2
Detoxifier
1
2
Genoprotective
1
2
Immunostimulatory
1
2
Insulin Sensitizers
1
2
Interferon-gamma (IFN-gamma) inducer
1
2
Leishmanicidal
1
2
Malondialdehyde Down-regulation
1
2
Neurorestorative
1
2
Nitric Oxide Inhibitor
1
2
Osteoprotective
1
2
Pancreato Protective Agents
1
2
Prophylactic Agents
1
2
Radioprotective
1
2
Radiosensitizer
1
2
Uricosuric Agents
1
2
Vascular Endothelial Growth Factor Regulator
1
2
Wnt/β-catenin pathway down-regulation
1
2
12-lipoxygenase (12-LOX) Inhibitor
1
1
Alpha-glucosidase inhibitor
1
1
Anabolic Agents
1
1
Anti-cancer
1
1
Antimalarials
1
1
Antiprotozoal Agents
1
1
Cyclin D1 Down-Regulation
1
1
Cyclooxygenase Inhibitors
1
1
Enzyme Inhibitors
1
1
Estrogen Receptor Agonist
1
1
Heat Shock Protein Inducer
1
1
Interleukin-10 downregulation
1
1
NF-E2-Related Factor-2 (Nrf2) Modulator
1
1
Neuritogenic
1
1
P21 Activation
1
1
Phase II Detoxification Enzyme Inducer
1
1
Photoprotective
1
1
Postaglandin PGE2 downregulation
1
1
SIRT1 Activator
1
1
STAT3 Inhibitor
1
1
Survivin Down-Regulation
1
1
TRAIL sensitizer
1
1
Telomerase Upregulation
1
1
Transforming growth factor beta (TGF-β) inhibitor
1
1
Vascular smooth muscle cell (VSMC) inhibitor
1
1
Wnt/β-catenin signaling pathway modulation
1
1
Research Articles
392
Cumulative Knowledge Score
634
Overall Research Rating
EXCELLENT
View the Evidence:
490 Abstracts with Natural Substance Synergy Research
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[+]
Synergistic and hepatoprotective effect of total glucosides of paeony on ankylosing spondylitis.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:231. Epub 2019 Mar 19. PMID:
30941036
Article Published Date
: Dec 31, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Peony
Diseases
:
Spondylitis: Ankylosing
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Natural Substance Synergy
[+]
A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.
Dec 31, 2011
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2012 ;64(4):550-8. Epub 2012 Apr 20. PMID:
22519865
Article Published Date
: Dec 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Folic Acid
,
Vitamin B-12
Diseases
:
Cervical Cancer
,
Folic Acid/Folate Deficiency
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Natural Substance Synergy
[+]
A combination of curcumin and fennel essential oil significantly improved symptoms and quality of life in IBS patients over 30 days.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Gastrointestin Liver Dis. 2016 Jun ;25(2):151-7. PMID:
27308645
Article Published Date
: May 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
,
Fennel
Diseases
:
Irritable Bowel Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Essential Oils
,
Natural Substance Synergy
,
Significant Treatment Outcome
[+]
A combination of green tea and ginkgo biloba extracts effectively improved skin conditions and the improvement of skin elasticity.
Aug 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Drugs Dermatol. 2014 Sep ;13(9):1092-7. PMID:
25226010
Article Published Date
: Aug 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Ginkgo biloba
,
Green Tea
Diseases
:
Aging Skin
Pharmacological Actions
:
Antioxidants
,
Dermatologic Agents
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
A combination of selenium and silymari led to a significant reduction in PSA levels.
Dec 14, 2013
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2013 Dec 15 ;21(1):75-81. Epub 2013 Sep 5. PMID:
24012146
Article Published Date
: Dec 14, 2013
Study Type
: Human Study
Additional Links
Substances
:
Milk Thistle
,
Selenium
Diseases
:
Prostate: PSA Doubling
,
Prostatic Hyperplasia
Additional Keywords
:
Natural Substance Synergy
,
Phytotherapy
,
Plant Extracts
[+]
A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Sci Nutr. 2015 Jan ;3(1):32-8. Epub 2014 Dec 12. PMID:
25649891
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Aloe Vera
,
Green Tea
,
Mangosteen
,
Riboflavin (Vitamin B-2)
,
Vitamin B-5 (Pantothenic Acid)
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Natural Substance Synergy
[+]
A herbal formulation is a safe and effective intervention for management of joint discomfort.
Apr 30, 2018
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2018 May ;21(5):511-520. Epub 2018 Apr 30. PMID:
29708818
Article Published Date
: Apr 30, 2018
Study Type
: Human Study
Additional Links
Substances
:
Frankincense
,
Haritaki (Terminalia chebula)
,
Turmeric
Diseases
:
Osteoarthritis: Knee
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
A joint consumption of apple juice, natural antioxidants and polyphenols might provide mild favorable effects on cardiometabolic markers, as compared to apple polyphenols alone.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2014 Dec ;53(8):1645-57. Epub 2014 Feb 16. PMID:
24531755
Article Published Date
: Nov 30, 2014
Study Type
: Human Study
Additional Links
Substances
:
Apples
,
Polyphenols
,
Vitamin C
Pharmacological Actions
:
Anticholesteremic Agents
,
Antioxidants
Additional Keywords
:
Fruit Juice
,
Natural Substance Synergy
[+]
Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex.
Nov 17, 2019
Click here to read the entire abstract
Pubmed Data
: Nutr Neurosci. 2019 Nov 18:1-12. Epub 2019 Nov 18. PMID:
31736428
Article Published Date
: Nov 17, 2019
Study Type
: Human Study
Additional Links
Substances
:
Bacopa
,
Coffee
,
Ginseng (American)
Diseases
:
Memory Disorders
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.
Aug 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2013 Sep ;23(9):843-9. Epub 2012 Aug 17. PMID:
22906565
Article Published Date
: Aug 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Anthocyanins
,
Cyanidin 3-glucoside
,
Delphinidin
Diseases
:
Atherosclerosis
,
C-Reactive Protein
,
High Cholesterol
,
Hypercholesterolemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords
:
Dose Response
,
Natural Substance Synergy
[+]
Chemopreventive synergism between green tea extract and curcumin in patients with potentially malignant oral disorders.
Apr 30, 2020
Click here to read the entire abstract
Pubmed Data
: J Contemp Dent Pract. 2020 May 1 ;21(5):521-531. Epub 2020 May 1. PMID:
32690834
Article Published Date
: Apr 30, 2020
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
,
Green Tea
Diseases
:
Oral Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Chemopreventive
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
Co-administration of flaxseed and hesperidin appears to be superior to either supplementation alone on metabolic syndrome treatment.
Apr 14, 2020
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2020 Apr 15. Epub 2020 Apr 15. PMID:
32296931
Article Published Date
: Apr 14, 2020
Study Type
: Human Study
Additional Links
Substances
:
Flaxseed
,
Hesperidin
Diseases
:
Metabolic Syndrome X
Pharmacological Actions
:
Hypolipidemic
,
Insulin Sensitizers
Additional Keywords
:
Natural Substance Synergy
[+]
Coenzyme Q10 and vitamin E had beneficial effects on cardiometabolic outcomes among women with polycystic ovary syndrome.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Arch Med Res. 2019 Feb ;50(2):1-10. Epub 2019 May 21. PMID:
31349945
Article Published Date
: Jan 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10
,
Vitamin E
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Constitutes of Boswellia serrata extract act synergistically to exert anti-inflammatory/anti-arthritic activity.
Mar 05, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Phytother Res. 2019 Mar 6. Epub 2019 Mar 6. PMID:
30838706
Article Published Date
: Mar 05, 2019
Study Type
: Human Study
Additional Links
Substances
:
acetyl-11-keto-beta-boswellic acid
,
Frankincense
Diseases
:
Osteoarthritis: Knee
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Natural Substance Synergy
[+]
CoQ10 and vitamin E supplementation had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels.
Sep 06, 2018
Click here to read the entire abstract
Pubmed Data
: J Clin Endocrinol Metab. 2018 Sep 7. Epub 2018 Sep 7. PMID:
30202998
Article Published Date
: Sep 06, 2018
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10
,
Vitamin E
Diseases
:
Polycystic Ovary Syndrome
Additional Keywords
:
Natural Substance Synergy
[+]
Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.
Jul 31, 2013
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2013 Aug ;19(8):709-13. Epub 2013 Mar 28. PMID:
23536963
Article Published Date
: Jul 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Angelica
,
Black Pepper
Diseases
:
Smoking Cessation: Nicotine Addiction
Therapeutic Actions
:
Aromatherapy
Additional Keywords
:
Natural Substance Synergy
[+]
Gazpacho soup consumption is associated with a lower prevalence of hypertension.
Sep 30, 2013
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2013 Oct ;23(10):944-52. Epub 2012 Nov 11. PMID:
23149074
Article Published Date
: Sep 30, 2013
Study Type
: Human Study
Additional Links
Substances
:
Polyphenols
,
Soup
Diseases
:
Cardiovascular Diseases
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Grapefruit juice enhances the systolic blood pressure-lowering effects of dietary nitrate-containing beetroot juice.
Jun 09, 2020
Click here to read the entire abstract
Pubmed Data
: Br J Clin Pharmacol. 2020 Jun 10. Epub 2020 Jun 10. PMID:
32520418
Article Published Date
: Jun 09, 2020
Study Type
: Human Study
Additional Links
Substances
:
Beet
,
Grapefruit
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Increased dietary ω-3 polyunsaturated fatty acids and extra virgin olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2015 Jun ;31(6):834-40. Epub 2015 Jan 3. PMID:
25933490
Article Published Date
: May 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Fish Oil
,
Olive Oil
Diseases
:
Cholesterol: High
,
Oxidative Stress
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Magnesium sulphate increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.
Nov 20, 2016
Click here to read the entire abstract
Pubmed Data
: Pain Manag. 2016 Nov 21. Epub 2016 Aug 21. PMID:
27866449
Article Published Date
: Nov 20, 2016
Study Type
: Human Study
Additional Links
Substances
:
Magnesium Sulfate
Diseases
:
Morphine Tolerance/Dependence
Additional Keywords
:
Natural Substance Synergy
[+]
Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID:
25625225
Article Published Date
: Mar 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Pycnogenol (Pine Bark)
Diseases
:
Fibrosarcoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.
Jan 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Gerontol A Biol Sci Med Sci. 2016 Feb ;71(2):236-42. Epub 2015 Aug 11. PMID:
26265727
Article Published Date
: Jan 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
EPA (Eicosapentaenoic Acid)
,
Folic Acid
,
Ginkgo biloba
,
Omega-3 Fatty Acids
,
Phosphatidylserine
,
Vitamin B-12
,
Vitamin E: alpha tocopherol
Diseases
:
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Asia Pac J Clin Nutr. 2009;18(3):310-7. PMID:
19786378
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Nattokinase
,
Red Yeast Rice
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.
Oct 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: In Vivo. 2009 Nov-Dec;23(6):1011-6. PMID:
20023248
Article Published Date
: Oct 31, 2009
Study Type
: Human Study
Additional Links
Substances
:
Lignans
,
Pine Cone
,
Vitamin C
Diseases
:
Herpes Simplex Virus Type 1
Pharmacological Actions
:
Anti-Infective Agents
,
Antiviral Agents
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
,
Recurrence Risk
,
Significant Treatment Outcome
[+]
Study suggests link between tea consumption and vitamin D levels
Aug 19, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr J. 2012 Aug 20 ;11(1):56. Epub 2012 Aug 20. PMID:
22905922
Article Published Date
: Aug 19, 2012
Study Type
: Human Study
Additional Links
Substances
:
Green Tea
Diseases
:
Vitamin D Deficiency
Additional Keywords
:
Natural Substance Synergy
[+]
The administration of cranberries, L. rhamnosus, and vitamin C might represent a safe and effective option in women with recurrent UTIs.
Jun 06, 2016
Click here to read the entire abstract
Pubmed Data
: Eur Urol. 2016 Jun 7. Epub 2016 Jun 7. PMID:
27283213
Article Published Date
: Jun 06, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cranberry
,
Lactobacillus rhamnosus
,
Vitamin C
Diseases
:
Urinary Tract Infections
Additional Keywords
:
Natural Substance Synergy
[+]
The combination hazelnut and cocoa may act in a synergic and protective way on cardiovascular system.
Jul 08, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2017 Jul 9:1-12. Epub 2017 Jul 9. PMID:
28691541
Article Published Date
: Jul 08, 2017
Study Type
: Human Study
Additional Links
Substances
:
Cocoa
,
Hazelnut
Diseases
:
Cardiovascular Disease: Prevention
Pharmacological Actions
:
Cardioprotective
Additional Keywords
:
Natural Substance Synergy
[+]
The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2015 Apr ;23(2):165-74. Epub 2015 Jan 14. PMID:
25847554
Article Published Date
: Mar 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Turmeric
Diseases
:
Metabolic Diseases
Pharmacological Actions
:
Antihypertensive Agents
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
,
Significant Treatment Outcome
[+]
The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of homocysteine.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asia Pac J Clin Nutr. 2015 ;24(3):403-11. PMID:
26420180
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Fish Oil
,
Omega-3 Fatty Acids
,
Vitamin B-12
Diseases
:
C-Reactive Protein
,
Cardiovascular Diseases
,
Homocysteine: Elevated
Additional Keywords
:
Natural Substance Synergy
[+]
The consumption of cooked whole eggs is an effective way to increase the absorption of α-tocopherol and γ-tocopherol from foods.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2016 Nov ;146(11):2199-2205. Epub 2016 Aug 21. PMID:
27655756
Article Published Date
: Oct 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Egg
,
Vitamin E: alpha tocopherol
,
Vitamin E: Gamma-Tocopherol
Additional Keywords
:
Food Bioavailability Enhancers
,
Natural Substance Synergy
[+]
The consumption of nuts is associated with better dietary and lifestyle patterns in Polish adults.
Jun 21, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 Jun 22 ;11(6). Epub 2019 Jun 22. PMID:
31234530
Article Published Date
: Jun 21, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nuts: All
Additional Keywords
:
Natural Substance Synergy
[+]
The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancers
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2014 Dec ;112(12):2002-9. Epub 2014 Oct 27. PMID:
25345471
Article Published Date
: Nov 30, 2014
Study Type
: Human Study
Additional Links
Substances
:
Lignans
,
Quercetin
,
Resveratrol
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Dietary Modification
,
Natural Substance Synergy
,
Plant Extracts
[+]
There is a synergistic interplay between curcumin and polyphenol-rich foods in the Mediterranean diet.
Jul 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Jul 21 ;9(7). Epub 2017 Jul 21. PMID:
28754004
Article Published Date
: Jul 20, 2017
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
,
Polyphenols
Diseases
:
Neurofibromatosis
Therapeutic Actions
:
Mediterranean diet
Additional Keywords
:
Natural Substance Synergy
,
Significant Treatment Outcome
[+]
These findings suggest a possible synergistic effect of nano-curcumin and coenzyme Q10 on clinical features of migraine.
Jun 25, 2019
Click here to read the entire abstract
Pubmed Data
: Nutr Neurosci. 2019 Jun 26:1-10. Epub 2019 Jun 26. PMID:
31241007
Article Published Date
: Jun 25, 2019
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10
,
Curcumin
Diseases
:
Headache: Migraine
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Prophylactic Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with osteoarthritis.
Jan 08, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2018 Jan 9 ;18(1):7. Epub 2018 Jan 9. PMID:
29316908
Article Published Date
: Jan 08, 2018
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
,
Frankincense
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Natural Substance Synergy
[+]
Use of aloe vera and turmeric paste as a supplementary medicine in oral submucosal fibrosis.
Sep 30, 2019
Click here to read the entire abstract
Pubmed Data
: Indian J Otolaryngol Head Neck Surg. 2019 Oct ;71(Suppl 1):883-886. Epub 2019 Jan 29. PMID:
31742088
Article Published Date
: Sep 30, 2019
Study Type
: Human Study
Additional Links
Substances
:
Aloe Vera
,
Turmeric
Diseases
:
Fibrosis
Additional Keywords
:
Natural Substance Synergy
[+]
Zinc and the Chinese herbal formula Jinye Baidu granule significantly increase the negative conversion rate of HCMV-IgM.
May 01, 2005
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 May;25(5):449-51. PMID:
15957842
Article Published Date
: May 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Chinese Herbal Formula: Jinye Baidu
,
Zinc
Diseases
:
Cytomegalovirus Infections
Pharmacological Actions
:
Antiviral Agents
Additional Keywords
:
Natural Substance Synergy
[+]
ω-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: Immunogenetics. 2017 Jun ;69(6):371-378. Epub 2017 May 6. PMID:
28478481
Article Published Date
: May 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
,
Omega-3 Fatty Acids
Diseases
:
Headache: Migraine
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.
Jul 31, 2012
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2012 Aug 1 ;84(3):402-10. Epub 2012 Mar 29. PMID:
22483777
Article Published Date
: Jul 31, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Amurensin G
Diseases
:
Cancers: Drug Resistant
,
Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions
:
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Cancer Stem Cells
,
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.
Jun 25, 2017
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2017 Jun 26. Epub 2017 Jun 26. PMID:
28650731
Article Published Date
: Jun 25, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Fisetin
,
Luteolin
Diseases
:
Diabetic Complications
,
Hyperglycemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma.
Oct 05, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2015 Oct 6. Epub 2015 Oct 6. PMID:
26452516
Article Published Date
: Oct 05, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Cucurbitacin B
,
Curcumin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Multidrug Resistance
,
Natural Substance Synergy
[+]
Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Breast Cancer. 2015 Sep ;18(3):225-34. Epub 2015 Sep 24. PMID:
26472972
Article Published Date
: Aug 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Citral
,
Curcumin
,
Lemongrass
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Natural Substance Synergy
,
Selective Cytotoxicity
[+]
Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.
May 08, 2012
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2012 May 8. Epub 2012 May 8. PMID:
22566066
Article Published Date
: May 08, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Ginseng
,
Green Tea
,
Panaxadiol
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Natural Substance Synergy
[+]
The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.
Sep 30, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxid Redox Signal. 2010 Oct 1 ;13(7):987-97. PMID:
20170403
Article Published Date
: Sep 30, 2010
Study Type
: Human In Vitro
Additional Links
Substances
:
Achiote
,
NAC (N-acetyl-L-cysteine)
Diseases
:
Cancers: Multi-Drug Resistant
,
Multiple Myeloma
,
Oxidative Stress
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
Additional Keywords
:
Natural Substance Synergy
,
Phytotherapy
,
Plant Extracts
,
Selective Cytotoxicity
[+]
The synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells was cytostatic, not cytotoxic.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2013 Jan ;84:347-59. Epub 2012 Dec 22. PMID:
23266736
Article Published Date
: Dec 31, 2012
Study Type
: Human In Vitro, In Vitro Study
Additional Links
Substances
:
Sesamin
,
Tocotrienol: Gamma
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Natural Substance Synergy
[+]
γ-tocotrienol and 6-gingerol when used in combination act synergistically increasing cytotoxicity and apoptosis in cancer cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2015 ;20(6):10280-97. Epub 2015 Jun 3. PMID:
26046324
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Gingerol
,
Tocotrienol: Gamma
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Natural Substance Synergy
[+]
Irvingia gabonensis extract has an analgesic effect.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2009 Jun;47(6):1176-1183. PMID:
7776661
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Irvingia gabonensis
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
SKN-1 is involved in combination of apple peels and blueberry extracts synergistically protecting against oxidative stress in Caenorhabditis elegans.
Jun 23, 2020
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2020 Jun 24 ;11(6):5409-5419. PMID:
32469357
Article Published Date
: Jun 23, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Apple
,
Blueberry
Diseases
:
Aging
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
[+]
Synergistic lipid-lowering effects of Zingiber mioga and Hippophae rhamnoides extracts.
Aug 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2020 Sep ;20(3):2270-2278. Epub 2020 Jun 19. PMID:
32765704
Article Published Date
: Aug 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Ginger
,
Sea buckthorn
Diseases
:
Obesity
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nanomedicine (Lond). 2020 Jan ;15(1):41-54. PMID:
31868113
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Betulinic acid
,
Ginsenosides
,
Honokiol
,
Parthenolide
Diseases
:
Lung Cancer
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Natural Substance Synergy
[+]
A combination of black bean peel and pomegranate peel extracts, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress induced damage to the pancreas.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2015 Jan ;9(1):43-48. Epub 2014 Oct 30. PMID:
25452774
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Beans: All
,
Black Bean
,
Pomegranate Peel
Diseases
:
Diabetes
,
Diabetes: Oxidative Stress
,
Hyperglycemia
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83. PMID:
25384193
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Turmeric
Diseases
:
Dyslipidemias
,
Endothelial Dysfunction
,
Fructose-Induced Toxicity
,
Hyperglycemia
,
Hyperinsulinism
,
Hypertension
,
Metabolic Diseases
Pharmacological Actions
:
Anticholesteremic Agents
,
Antihypertensive Agents
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
,
Risk Reduction
[+]
A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.
Sep 01, 2016
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2016 Sep 2:1-9. Epub 2016 Sep 2. PMID:
27875075
Article Published Date
: Sep 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chamomile
,
Oregano
Diseases
:
Diabetic Complications
Pharmacological Actions
:
Alpha-amylase inhibitor
,
Anti-Apoptotic
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
Problem Substances
:
Alloxan
[+]
A combination of five main alkaloids from Rhizoma Coptidis showed a synergetic cholesterol-lowering efficacy.
Apr 14, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Apr 15 ;151:50-60. Epub 2016 Feb 11. PMID:
26876917
Article Published Date
: Apr 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Coptidis rhizoma
Diseases
:
Cardiovascular Disease: Prevention
,
Hypercholesterolemia
,
Hyperlipidemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Hepatoprotective
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
A combination of Korean red ginseng extract and Glycyrrhiza glabra L. extract enhances their individual anti-obesity properties.
Feb 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Food. 2020 Mar ;23(3):215-223. PMID:
32191576
Article Published Date
: Feb 29, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (Korean)
,
Licorice
Diseases
:
Dyslipidemias
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Natural Substance Synergy
[+]
A combination of lycopene and vitamin E acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2017 ;57(2):475-482. PMID:
28269786
Article Published Date
: Dec 31, 2016
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Lycopene
,
Vitamin E
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.
Jul 29, 2015
Click here to read the entire abstract
Pubmed Data
: Metab Brain Dis. 2015 Jul 30. Epub 2015 Jul 30. PMID:
26220010
Article Published Date
: Jul 29, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Ferulic acid
,
Piperine
Diseases
:
Depressive Disorder
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Increased Bioavailability
,
Natural Substance Synergy
[+]
A combination of pomegranate, date fruit and date seeds led to a more potent treatment result than each alone.
Mar 25, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 Mar 26. Epub 2015 Mar 26. PMID:
25811166
Article Published Date
: Mar 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Dates
,
Polyphenols
,
Pomegranate
Diseases
:
Atherosclerosis
,
Oxidative Stress
,
Triglycerides: Elevated
Pharmacological Actions
:
Anti-atherogenic
,
Anticholesteremic Agents
,
Antioxidants
Additional Keywords
:
Natural Substance Synergy
[+]
A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.
Feb 06, 2017
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2017 Feb 7. Epub 2017 Feb 7. PMID:
28222524
Article Published Date
: Feb 06, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Diseases
:
Aluminum Toxicity
,
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
Problem Substances
:
Aluminum Chloride
[+]
A curcumin-artemisinin combination is effective for malaria.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Antimicrob Agents Chemother. 2006 May;50(5):1859-60. PMID:
16641461
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Artemisinin
,
Curcumin
Diseases
:
Malaria
Additional Keywords
:
Natural Substance Synergy
[+]
A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.
Jul 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Sci Biotechnol. 2018 Aug ;27(4):1193-1200. Epub 2018 Apr 4. PMID:
30263850
Article Published Date
: Jul 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (Korean)
,
Kudzu
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Acetylcholinesterase Inhibitor
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft.
Nov 26, 2019
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2019 Nov 27 ;72:110659. Epub 2019 Nov 27. PMID:
31986320
Article Published Date
: Nov 26, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Therapeutic Actions
:
Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
,
Natural Substance Synergy
[+]
A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Wiad Lek. 2017;70(2):200-204. PMID:
28511159
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Apple Polyphenols
,
Catechin
,
EGCG (Epigallocatechin gallate)
,
Quercetin
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
A sea buckthorn and olive oil mixture could be considered as an alternative dressing for full-thickness burns.
Jun 30, 2014
Click here to read the entire abstract
Pubmed Data
: Adv Skin Wound Care. 2014 Jul ;27(7):317-23. PMID:
24932952
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Olive Oil
,
Sea buckthorn
Diseases
:
Burns
,
Wound Healing
Pharmacological Actions
:
Anti-Bacterial Agents
Additional Keywords
:
Natural Substance Synergy
[+]
A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria.
Feb 29, 2012
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2012 Mar ;29(3):447-53. Epub 2011 Dec 5. PMID:
22160132
Article Published Date
: Feb 29, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Natural Substance Synergy
[+]
ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with AI or CL alone.
Jul 22, 2015
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2015 Jul 23. Epub 2015 Jul 23. PMID:
26212022
Article Published Date
: Jul 22, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Mugwort
,
Turmeric
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Administration of melatonin and vitamin C as radioprotectors before irradiation may reduce genotoxicity caused by x-ray irradiation.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell J. 2016 ;18(1):46-51. Epub 2016 Apr 4. PMID:
27054118
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Vitamin C
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
Additional Keywords
:
Natural Substance Synergy
Anti Therapeutic Actions
:
Radiotherapy
[+]
Administration of vitamins C and E in combination may exert synergistic antinociceptive effects.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2011 ;6(12):e29240. Epub 2011 Dec 14. PMID:
22195029
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Hyperalgesia
,
Inflammation
,
Peripheral Neuropathies
Pharmacological Actions
:
Analgesics
,
Antinoceceptive
Additional Keywords
:
Natural Substance Synergy
[+]
Amelioration of oxidative stress by dietary fenugreek seeds is potentiated by onion in streptozotocin-induced diabetic rats.
Mar 19, 2017
Click here to read the entire abstract
Pubmed Data
: Appl Physiol Nutr Metab. 2017 Mar 20. Epub 2017 Mar 20. PMID:
28319671
Article Published Date
: Mar 19, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Fenugreek
,
Onion
Diseases
:
Diabetes: Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
[+]
Andrographis and Hedyotis corymbosa in combination with curcumin have anti-malaria action.
Feb 01, 2004
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2004 Feb;18(2):164-8. PMID:
19216765
Article Published Date
: Feb 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Andrographis
,
Curcumin
,
Hedyotis corymbosa
Diseases
:
Malaria
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
Antioxidants exhibited protective effects against D-galactose-induced oxidative damage in rats.
Mar 29, 2016
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2016 Mar 30. Epub 2016 Mar 30. PMID:
27025718
Article Published Date
: Mar 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Purple Carrots
,
Selenium
,
Vitamin E
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Natural Substance Synergy
[+]
Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.
Nov 13, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2006 Nov 14 ;12(42):6835-41. PMID:
17106933
Article Published Date
: Nov 13, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Cholestasis
,
Liver Cirrhosis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Fibrotic
,
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Apple polyphenol extracts might emerge as a promising nutritional ingredient in the management of chronic diseases such as diabetes.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Metab (Lond). 2016 ;13:32. Epub 2016 Apr 30. PMID:
27141227
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apple Polyphenols
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Insulin Sensitizers
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
Artemisinin and curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity.
Jun 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: IUBMB Life. 2014 Jul ;66(7):496-506. Epub 2014 Jun 27. PMID:
24975030
Article Published Date
: Jun 30, 2014
Study Type
: Insect Study
Additional Links
Substances
:
Artemisinin
,
Curcumin
Diseases
:
Brain Cancer
Pharmacological Actions
:
Antineoplastic Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Artificial tears containing epigallocatechin gallate and hyaluronic acid had a synergistic effect in the treatment of dry eye syndrome.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016;11(6):e0157982. Epub 2016 Jun 23. PMID:
27336157
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dry Eye Syndromes
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Astaxanthin reduces the susceptibility to oxidation and potentizes the immunomodulatory properties of fish oil.
Oct 05, 2011
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2011 Oct 5. Epub 2011 Oct 5. PMID:
21972007
Article Published Date
: Oct 05, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
,
Fish Oil
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Immunomodulatory
,
Interleukin-1 beta downregulation
Additional Keywords
:
Natural Substance Synergy
[+]
Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2017 02 ;37(2):465-473. PMID:
28179291
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
,
Curcumin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
MicroRNA modulator
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Natural Substance Synergy
[+]
Astragalus polysaccharides combined with Crataegus flavonoids may facilitate the treatment of type 1 or 2 diabetes.
Apr 14, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Apr 15. Epub 2016 Apr 15. PMID:
27081750
Article Published Date
: Apr 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragalus
,
Hawthorn
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.
Jun 05, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 Jun 6 ;190:83-90. Epub 2016 Jun 6. PMID:
27282665
Article Published Date
: Jun 05, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragalus
,
Licorice
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Anti-Inflammatory Agents
,
Hepatoprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.
Aug 19, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID:
30123925
Article Published Date
: Aug 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Bael
,
Piperine
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Bamboo extracts were found to modulate the immunostimulating effects of medicinal mushrooms.
Dec 31, 2011
Click here to read the entire abstract
Pubmed Data
: Int J Med Mushrooms. 2012 ;14(6):537-47. PMID:
23510247
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Bamboo
,
Beta-glucan
,
Medicinal Mushrooms
Pharmacological Actions
:
Immunostimulatory
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(2):e0147745. Epub 2016 Feb 16. PMID:
26881746
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Bisdemethoxycurcumin
,
Silymarin
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Blackberry juice and quercetin together significantly reduced sodium fluoride induced oxidative and histological changes in rats.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2015 May 1 ;26(3):237-51. PMID:
25918918
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Blackberry
,
Quercetin
Diseases
:
Fluoride Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
,
Hepatoprotective
,
Renoprotective
Additional Keywords
:
Natural Substance Synergy
Problem Substances
:
Sodium Fluoride
[+]
Calcitriol enhances pyrazinamide treatment of murine tuberculosis.
Sep 04, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Chin Med J (Engl). 2019 Sep 5 ;132(17):2089-2095. PMID:
31425356
Article Published Date
: Sep 04, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin D
Diseases
:
Tuberculosis
Pharmacological Actions
:
Anti-Bacterial Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Cannabidiol enhanced the ability of THC to inhibit cell proliferation, induce cell cycle arrest and apoptosis.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID:
20053780
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Cancer Metastasis
,
Glioblastoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Cannabinoid Receptors
,
Natural Substance Synergy
[+]
Cannabidiol potentiates pharmacological effects of THC.
Jan 09, 2008
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2008 Jan 10 ;1188:157-64. Epub 2007 Oct 12. PMID:
18021759
Article Published Date
: Jan 09, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Memory Disorders
Additional Keywords
:
Natural Substance Synergy
[+]
Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction.
Apr 19, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2017 Apr 20. Epub 2017 Apr 20. PMID:
28440400
Article Published Date
: Apr 19, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Carnosic Acid
,
Fisetin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Natural Substance Synergy
[+]
Chrysanthemum indicum and Cinnamomum cassia mixture may have potential as a treatment for hyperuricemia and gout.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2017 ;2017:9764843. Epub 2017 Jul 9. PMID:
28769989
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chrysanthemum Indicum
,
Cinnamon
Diseases
:
Gout
,
Hyperuricemia
Pharmacological Actions
:
Uricosuric Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.
Jun 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2014 Jul ;8(1):260-266. Epub 2014 May 16. PMID:
24944632
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
High Fat Diet
,
Hyperlipidemia
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substance Synergy
[+]
Coconut and holy basil rescued the affected mice from the disease.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: J Parasit Dis. 2017 Mar ;41(1):76-85. Epub 2016 Apr 4. PMID:
28316391
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Coconut
,
Holy Basil
Diseases
:
Leishmaniasis
Pharmacological Actions
:
Immunomodulatory
,
Leishmanicidal
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
Colon tumors in Pirc rats were significantly reduced by 3,3'-diindolylmethane and curcumin.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2015 ;15(1):611. Epub 2015 Sep 3. PMID:
26335331
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Natural Substance Synergy
[+]
Combination of berberine with resveratrol improves the lipid-lowering efficacy.
Dec 05, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2018 Dec 6 ;19(12). Epub 2018 Dec 6. PMID:
30563192
Article Published Date
: Dec 05, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Resveratrol
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice.
Feb 21, 2019
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2019 Feb 22. Epub 2019 Feb 22. PMID:
30802477
Article Published Date
: Feb 21, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Asiatic Acid
,
Carnosine
Diseases
:
Diabetic Complications
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Combination of curcumin and luteolin synergistically inhibits TNF-α-induced vascular inflammation in human vascular cells and mice.
Aug 14, 2019
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2019 Aug 15 ;73:108222. Epub 2019 Aug 15. PMID:
31665675
Article Published Date
: Aug 14, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
,
Luteolin
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.
Jan 11, 2017
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID:
28089829
Article Published Date
: Jan 11, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Capsaicin
,
Piceatannol
,
Resveratrol
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemosensitizer
,
Chemotherapeutic
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
,
Natural Substance Synergy
[+]
Combination of white tea and peppermint demonstrated synergistic antibacterial and anti-inflammatory activities.
Oct 14, 2020
Click here to read the entire abstract
Pubmed Data
: J Sci Food Agric. 2020 Oct 15. Epub 2020 Oct 15. PMID:
33058206
Article Published Date
: Oct 14, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Peppermint
,
White Tea
Diseases
:
Staphylococcal Infections
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Combination therapy of niacin and selenium attenuated lung injury and improved survival during sepsis.
Dec 01, 2015
Click here to read the entire abstract
Pubmed Data
: Crit Care Med. 2015 Dec 2. Epub 2015 Dec 2. PMID:
26646455
Article Published Date
: Dec 01, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Niacin
,
Selenium
Diseases
:
Sepsis
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Natural Substance Synergy
[+]
Combination therapy using CoQ(10) and creatine may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease and Huntington Disease.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2009 Jun;109(5):1427-39. Epub 2009 Mar 28. PMID:
19476553
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
,
Creatine
Diseases
:
Huntington Disease
,
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Combined administration of selenium enriched green tea polysaccharides and Huo-ji polysaccharides synergistically improve immune function and decrease the oxidative stress.
Jun 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Sci Food Agric. 2015 Jul 1. Epub 2015 Jul 1. PMID:
26130565
Article Published Date
: Jun 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Green Tea
,
Selenium
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
,
Interleukin-6 Downregulation
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
,
Polysaccharides
[+]
Combined administration of vitamin C and L-carnitine could prevent the adverse effects of cisplatin on gastric tissues.
Apr 19, 2018
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2018 Apr 20. Epub 2018 Apr 20. PMID:
29677454
Article Published Date
: Apr 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
L-Carnitine
,
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
,
Gastroprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Combined application of propolis and honey on the open wound healing in rats has a synergistic effect.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Med Iran. 2016 Apr ;54(4):233-9. PMID:
27309263
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Honey
Diseases
:
Wound Healing
Additional Keywords
:
bee propolis
,
Honey
,
Natural Substance Synergy
,
wound healing
[+]
Combined curcumin and resveratrol reduces prostate cancer incidence in mice.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2009 Jul 1;125(1):1-8. PMID:
19326431
Article Published Date
: Jul 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Natural Substance Synergy
,
Stilbenes
[+]
Combined pretreatment with the extract of Nardosatchys jatamansi, crocetin and selenium led to improved behavioural outcomes.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Neurol Sci. 2012 Oct ;33(5):1011-20. Epub 2011 Dec 15. PMID:
22170092
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Crocetin
,
Selenium
,
Spikenard
Diseases
:
Cognitive Decline/Dysfunction
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
,
Phytotherapy
[+]
Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on type 1 diabetic rats.
Mar 01, 2010
Click here to read the entire abstract
Pubmed Data
: Gen Physiol Biophys. 2010 Mar;29(1):23-30. PMID:
20371877
Article Published Date
: Mar 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid
,
Curcumin
Diseases
:
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Combining curcumin with guar gum may help increase its effectiveness in treating colon cancer.
Jan 01, 2007
Click here to read the entire abstract
Pubmed Data
: Drugs Aging. 2007;24(11):945-55. PMID:
20614824
Article Published Date
: Jan 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Guar gum
Diseases
:
Colon Cancer
,
Colorectal Cancer
Additional Keywords
:
Natural Substance Synergy
[+]
Combining green tea polyphenols and quercetin significantly enhanced the antiproliferative and proapoptotic effect in vivo.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr Biochem. 2014 Jan ;25(1):73-80. Epub 2013 Oct 10. PMID:
24314868
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Green Tea
,
Quercetin
Diseases
:
Prostate Cancer
,
Prostate Cancer: Prevention
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Bioavailability
,
Multidrug Resistance
,
Natural Substance Synergy
[+]
Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Sep ;93:948-960. Epub 2017 Jul 14. PMID:
28715876
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Licorice
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
Chemotherapeutic
Additional Keywords
:
Natural Substance Synergy
[+]
Comparison of acute and chronic effects of Bacopa monnieri, Ginkgo biloba, and Lavandula angustifolia and their mixture on learning and memory in mice.
Jan 10, 2021
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2021 Jan 11. Epub 2021 Jan 11. PMID:
33429454
Article Published Date
: Jan 10, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Bacopa
,
Ginkgo biloba
,
Lavender
Diseases
:
Amnesia
,
Memory Disorders
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Compounds in oats are bioavailable and act synergistically with vitamin C enhance hamster and human LDL resistance to oxidation.
Jun 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2004 Jun;134(6):1459-66. PMID:
15173412
Article Published Date
: Jun 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Oats
,
Polyphenols
,
Vitamin C
Diseases
:
Cholesterol: Oxidation
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
[+]
Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID:
20020926
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
DNA damage
,
Myelotoxicity
Pharmacological Actions
:
Genoprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin and boswellic acid induced upregulation of tumor suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2015 May ;8(5):431-43. Epub 2015 Feb 23. PMID:
25712055
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Boswellia
,
Curcumin
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
,
MicroRNA modulator
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin and capsaicin individually are protective to LDL oxidation both in vivo and in vitro, to iron-induced hepatotoxicity and to carrageenan-induced inflammation.
Aug 26, 2009
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2009 Aug 26;57(16):7401-8. PMID:
16956363
Article Published Date
: Aug 26, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Capsaicin
,
Curcumin
Diseases
:
Chemically-Induced Liver Damage
,
Cholesterol: Oxidation
,
Inflammation
,
Iron Poisoning
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin and phenethyl isothiocyanate have a synergistic inhibitory effect on the growth of human prostate xenografts.
Jul 01, 2008
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID:
16423986
Article Published Date
: Jul 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Phenethyl isothiocyanate
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Isothiocyanates
,
Natural Substance Synergy
[+]
Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.
Nov 15, 2016
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2016 Nov 16. Epub 2016 Nov 16. PMID:
27853890
Article Published Date
: Nov 15, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
Brain Inflammation
,
Parkinson's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Brain Inflammation
,
CURCUMIN
,
Interleukin-1 beta downregulation
,
Natural Substance Synergy
,
Parkinson's disease
,
Piperine
[+]
Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.
Jan 29, 2016
Click here to read the entire abstract
Pubmed Data
: Pharmacology. 2016 Jan 30 ;97(3-4):151-160. Epub 2016 Jan 30. PMID:
26828892
Article Published Date
: Jan 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin and resveratrol effectively prevent benzo(a)pyrene induced testicular germ cell apoptosis and restore male reproductive health.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:245. Epub 2016 Aug 8. PMID:
27551266
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Pharmacological Actions
:
Anti-Apoptotic
,
Bax/Bcl2 Ratio: Decrease
Additional Keywords
:
Natural Substance Synergy
Problem Substances
:
Benzo(a)pyrene
[+]
Curcumin and resveratrol work synergistically to improve the condition of mice with lung cancer.
Dec 29, 2009
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2009 Dec 29. Epub 2009 Dec 29. PMID:
20041413
Article Published Date
: Dec 29, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Diseases
:
Lung Cancer
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of dietary green tea extract.
Jun 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: BMC Complement Altern Med. 2019 Jun 13 ;19(1):129. Epub 2019 Jun 13. PMID:
31196040
Article Published Date
: Jun 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
Curcumin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Antioxidants
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.
Dec 31, 2014
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Article Publish Status
: This is a free article.
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Pubmed Data
: Lipids Health Dis. 2015 ;14(1):100. Epub 2015 Sep 3. PMID:
26335572
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
Gallstones
,
High Fat Diet
Additional Keywords
:
Increased Bioavailability
,
Natural Substance Synergy
[+]
Curcumin in combination with EPA and DHA work synergistically to reduce inflammation.
Feb 01, 2010
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Pubmed Data
: Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8. PMID:
19744468
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
DHA (Docosahexaenoic Acid)
,
EPA (Eicosapentaenoic Acid)
Diseases
:
Cancers: All
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antineoplastic Agents
,
Antioxidants
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own.
Jul 25, 2015
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Pubmed Data
: Environ Toxicol Pharmacol. 2015 Jul 26 ;40(2):445-452. Epub 2015 Jul 26. PMID:
26278679
Article Published Date
: Jul 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin might increase the effect of vitamin C in protecting the function of endothelial cells through its anti-oxidant with hypoglycemic and hypolipidemic actions.
Jan 01, 2006
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Pubmed Data
: Clin Hemorheol Microcirc. 2006;35(4):481-9. PMID:
17148847
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Vitamin C
Diseases
:
Dyslipidemias
,
Endothelial Dysfunction
Pharmacological Actions
:
Antioxidants
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin synergistically increases effects of beta-interferon and retinoic acid on breast cancer cells in vitro and in vivo.
Sep 27, 2016
Click here to read the entire abstract
Pubmed Data
: J Drug Target. 2016 Sep 28:1-23. Epub 2016 Sep 28. PMID:
27677346
Article Published Date
: Sep 27, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin, resveratrol, and EGCG, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors.
Feb 15, 2018
Click here to read the entire abstract
Pubmed Data
: Cancer Immunol Immunother. 2018 Feb 16. Epub 2018 Feb 16. PMID:
29453519
Article Published Date
: Feb 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Head and Neck Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin-manganese complexes have enhanced antioxidant activity.
Dec 15, 2003
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Pubmed Data
: Free Radic Biol Med. 2003 Dec 15;35(12):1632-44. PMID:
14680686
Article Published Date
: Dec 15, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Manganese
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Cyanocobalamin and cholecalciferol synergistically improve functional and histopathological nerve healing.
Mar 29, 2020
Click here to read the entire abstract
Pubmed Data
: Ideggyogy Sz. 2020 Mar 30 ;73(3-4):113-120. PMID:
32364338
Article Published Date
: Mar 29, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin B-12
,
Vitamin D
Diseases
:
Peripheral Neuropathies
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Natural Substance Synergy
,
Nerve Regeneration
[+]
Danshensu plus hydroxysafflor yellow A could achieve remarkable synergistic neuroprotective effects on ischemia-reperfusion injury.
Dec 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Oncotarget. 2017 Dec 29 ;8(70):115434-115443. Epub 2017 Dec 15. PMID:
29383171
Article Published Date
: Dec 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Safflower
,
Salvia miltiorrhiza
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Neuroprotective Agents
,
Nrf2 activation
Additional Keywords
:
Natural Substance Synergy
[+]
Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic mice.
Aug 06, 2008
Click here to read the entire abstract
Pubmed Data
: Forensic Sci Int. 2008 Aug 6;179(2-3):e25-9. Epub 2008 Jun 6. PMID:
17715888
Article Published Date
: Aug 06, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Fish Oil
,
Fucoxanthin
Diseases
:
Diabetes Mellitus: Type 2
,
Obesity
Additional Keywords
:
Natural Substance Synergy
[+]
Drinking green tea may reduce the toxic potential of acute high oral doses of EGCG supplementation.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2015 Feb ;76:103-8. Epub 2014 Dec 17. PMID:
25528115
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Bioavailability
,
Natural Substance Synergy
,
Supplementation
[+]
Effect of fermented Spirulina maxima extract on cognitive-enhancing activities in mice with scopolamine-induced dementia.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:7218504. Epub 2018 Nov 26. PMID:
30598686
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Fermented Foods and Beverages
,
Spirulina
Diseases
:
Dementia
Pharmacological Actions
:
Brain-derived neurotrophic factor modulator
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Future Microbiol. 2018 09 ;13:1375-1382. Epub 2018 Sep 26. PMID:
30256168
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Grape Seed Extract
,
Pea Protein
Diseases
:
Candida Albicans
,
Candidiasis: Vulvovaginal
Pharmacological Actions
:
Antifungal Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Effect of the proportion of curcuminoids on the gastroprotective action of Curcuma longa L. in rats.
Jul 23, 2019
Click here to read the entire abstract
Pubmed Data
: Nat Prod Res. 2019 Jul 24:1-6. Epub 2019 Jul 24. PMID:
31339383
Article Published Date
: Jul 23, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Curcuminoids
,
Turmeric
Pharmacological Actions
:
Gastroprotective
Additional Keywords
:
Natural Substance Synergy
[+]
Effects of puerarin on the pharmacokinetics of triptolide in rats.
Nov 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Pharm Biol. 2019 Dec ;57(1):407-411. PMID:
31230510
Article Published Date
: Nov 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Puerarin
,
Triptolide
Additional Keywords
:
Natural Substance Synergy
[+]
EGCG can be used as an enhanced supplement for huperzine A to treat Alzheimer's disease.
Aug 01, 2009
Click here to read the entire abstract
Pubmed Data
: Nutr Neurosci. 2009 Aug;12(4):142-8. PMID:
19622237
Article Published Date
: Aug 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
Huperzine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin.
Mar 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Carcinogenesis. 2011 Apr ;32(4):561-7. Epub 2011 Jan 27. PMID:
21273642
Article Published Date
: Mar 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
,
Silibinin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
Additional Keywords
:
Natural Substance Synergy
[+]
Eriodictyol synergistically potentiates the anti-tumour effect of EGCG by amplifying 67LR-dependent signalling in MM cells
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:9474. Epub 2015 Mar 31. PMID:
25824377
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Eriodictyol
,
Yerba Santa
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Bioenhancer
,
EGCG Sensitizer
,
Natural Substance Synergy
[+]
Essential oil S. aromaticum and ethanolic extract R. officinalis could be useful in combination with ketorolac for the treatment of inflammatory pain.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Oct ;94:858-864. Epub 2017 Aug 10. PMID:
28802239
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Clove
,
Rosemary
Diseases
:
Inflammation
Pharmacological Actions
:
Antinoceceptive
Additional Keywords
:
Natural Substance Synergy
[+]
Ferulic acid enhances the vasorelaxant properties of EGCG in TNF-α-induced inflammatory aorta.
Jun 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2014 Jul ;25(7):807-14. Epub 2014 Apr 4. PMID:
24794014
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Ferulic acid
Diseases
:
Inflammation
Pharmacological Actions
:
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vasodilator Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Fig extract and extra virgin olive oil have a powerful antioxidant and many protective effects against cardiac and renal toxicity induced by 5-FU.
Sep 17, 2020
Click here to read the entire abstract
Pubmed