Natural Substance/Drug Synergy

Name	AC	CK
Fluoxetine (trade name Prozac)	2	20
Sertraline	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	11
Antidepressants	1	10
Mesalamine	1	10
Simvastatin	1	10
Statin Drugs	1	10
Doxorubicin	2	7
Antibiotics	4	4
Cisplatin	2	4
Fluorouracil (5-FU or f5U)	1	2
Nicotine	1	2
Paclitaxel	1	2
Prednisolone	1	2
Zoledronic Acid	1	2

Name	AC	CK
Depression	5	50
Breast Cancer	17	34
Colorectal Cancer	7	33
Helicobacter Pylori Infection	5	23
Depression: Postmenopausal	2	20
Cancers: All	13	18
Oxidative Stress	6	17
Cancers: Drug Resistant	8	15
Rheumatoid Arthritis	3	13
Chronic Pain	2	11
Ulcerative Colitis	2	11
Acute lymphoblastic leukemia (ALL)	1	10
Anxiety Disorders	1	10
Atherosclerosis	1	10
Breast Cancer: Metastatic	1	10
C-Reactive Protein	1	10
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	10
Cholesterol: High	1	10
Colorectal Adenomas	1	10
Depressive Disorder	1	10
Drug-Induced Toxicity: Methotrexate	1	10
High Cholesterol	1	10
Peripheral Arterial Disease	1	10
Triglycerides: Elevated	1	10
Colon Cancer	6	9
Lung Cancer	6	9
Multiple Myeloma	6	9
Breast Cancer: Triple Negative	5	7
Carcinoma: Non-Small-Cell Lung	4	7
Leukemia	7	7
Staphylococcus aureus: Methicillin-resistant (MRSA)	7	7
Gastric Cancer	4	6
Prostate Cancer	5	6
Arthritis	3	5
Breast Cancer Stem Cells	1	5
Breast Cancer: Drug Resistant	1	5
Ebola Virus Infections	1	5
Escherichia coli Infections	5	5
Pancreatic Cancer	4	5
Staphylococcus aureus infection	5	5
Allodynia	2	4
Lipid Peroxidation	2	4
Neuropathic Pain	2	4
Pseudomonas aeruginosa	4	4
Toxoplasma gondii Infection	2	4
Candida Albicans	2	3
Chemotherapy-Induced Toxicity	2	3
Esophageal Cancer	2	3
Inflammation	2	3
Liver Cancer	2	3
Melanoma	2	3
Acute Myeloid Leukemia	2	2
Candida Infection	2	2
Candidiasis	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Cryptococcosis	1	2
Fibrosarcoma	1	2
Glioblastoma	2	2
Glioma	2	2
Gram-Negative Bacterial Infections	2	2
Hyperalgesia	1	2
Inflammatory Bowel Diseases	1	2
Kidney Cancer	2	2
Liver Metastasis From Colon Cancer	1	2
Malignant Melanoma	1	2
Memory Loss	1	2
Sepsis	1	2
Skin Cancer	1	2
Toxoplasmosis	1	2
AIDS	1	1
Alzheimer's Disease	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cachexia: Cancer	1	1
Campylobacter Infections	1	1
Cancer Metastasis	1	1
Cancer: Pain	1	1
Cancers: Multi-Drug Resistant	1	1
Carcinosarcomas	1	1
Cardiovascular Disease	1	1
Cervical Cancer	1	1
Chemotherapy	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chemotherapy-Induced Toxicity: Tamoxifen	1	1
Chronic Lymphocytic Leukemia	1	1
Cystic Fibrosis	1	1
Diabesity	1	1
Epilepsy	1	1
Epileptic Seizures	1	1
Fungal Infections: Biofilm Formation/Resistance	1	1
Glioblastoma Multiforme	1	1
Gram-Positive Bacterial Infections	1	1
Headache	1	1
Klebsiella Infections	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Melanoma: Metastatic	1	1
Mycobacterium tuberculosis	1	1
Neurofibromatosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Oral Cancer	1	1
Osteosarcoma	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Peripheral Neuropathies	1	1
Radiation Induced Illness	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Schwannoma	1	1
Squamous cell carcinoma	1	1
Streptococcus pyogenes	1	1

Name	AC	CK
Curcumin	26	59
Chinese Skullcap	2	21
Astragalus	1	20
Hedyotis corymbosa	1	20
Soy	2	20
EGCG (Epigallocatechin gallate)	7	13
Silibinin	4	13
Vitamin D	3	13
Cannabis	3	12
Melatonin	3	12
Nigella sativa (aka Black Seed)	2	12
Fucoidan	2	11
Pomegranate	2	11
Quercetin	10	11
Flaxseed	1	10
Lactobacillus reuteri	1	10
Lavender	1	10
Piperidines	1	10
Probiotics	1	10
Green Tea	4	9
Vitamin C	5	8
Catechin	3	7
Gingerol	3	7
Wogonin	4	7
Pterostilbene	2	6
6-Shogaol	1	5
Amurensin G	1	5
Cannabidiol	4	5
Plantago major	1	5
Prunella vulgaris.	1	5
Resveratrol	4	5
Berberine	4	4
Cannabinoids	4	4
Cannabinoids: Synthetic	2	4
Polyphenols	4	4
Sulforaphane	3	4
Turmeric	4	4
Anthocyanins	2	3
Honokiol	3	3
Olive leaf extract	2	3
Thymoquinone	2	3
Allspice	1	2
Banana	1	2
Beta-glucan	1	2
Black Tea	2	2
Capsaicin	2	2
Chrysin	1	2
Cyanidin 3-glucoside	1	2
Devils Claw	1	2
Emodin	2	2
Evening Primrose Oil	1	2
Garlic: Aged	1	2
Ginger	2	2
Luteolin	1	2
Magnolol	2	2
Maitake Mushroom	1	2
Mangiferin	2	2
Nobiletin	1	2
Piperine	2	2
Puerarin	1	2
Resistant Starch	1	2
Vitamin E: alpha tocopherol	1	2
Allicin	1	1
Aloe Vera	1	1
Antrodia cinnamomea	1	1
Asparagus	1	1
Baicalein	1	1
Basil	1	1
Beans: All	1	1
Bee Venom	1	1
Beet	1	1
Bergamot orange	1	1
Bitter Melon	1	1
Black Currant	1	1
Blueberry	1	1
Cafestol	1	1
Cayenne	1	1
Celery seed	1	1
Chokeberry	1	1
Citrus naringin	1	1
Cruciferous Vegetables	1	1
Cucurbitacin B	1	1
Echinacea	1	1
Erucin	1	1
Fruit: All	1	1
Fucoxanthin	1	1
Genistein	1	1
Ginseng (Korean)	1	1
Ginsenosides	1	1
Glycyrrhizin	1	1
Grape	1	1
Grape Seed Extract	1	1
Hesperidin	1	1
Hibiscus sabdariffa	1	1
Indole-3-Carbinol	1	1
Isothiocyanates	1	1
Lutein	1	1
Magnolia	1	1
Manuka Honey	1	1
Maple Syrup	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Plum	1	1
Rice Bran	1	1
Seaweed: Brown	1	1
Silver (nanoparticles)	1	1
Silymarin	1	1
Tangeretin	1	1
Theaflavins	1	1
Tocotrienols	1	1
Tomato	1	1
Vanillin	1	1
Vegetables: All	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin K	1	1
Watercress	1	1
Wheat Grass	1	1
Zinc	1	1
beta-Carotene	1	1

Name	AC	CK	Focus
Integrative Medicine	2	3

Name	AC	CK
Apoptotic	48	71
Antiproliferative	47	69
Antidepressive Agents	5	50
Chemosensitizer	22	44
Anti-Inflammatory Agents	13	35
Antioxidants	15	31
Chemotherapeutic	14	27
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	24
Antineoplastic Agents	13	19
Anti-Bacterial Agents	16	16
Analgesics	5	15
Chemopreventive	9	15
Anti-metastatic	11	13
Cell cycle arrest	10	12
Hepatoprotective	2	12
Interleukin-1 beta downregulation	2	12
Interleukin-8 downregulation	2	11
Anti-atherogenic	1	10
Anticholesteremic Agents	1	10
Hypolipidemic	1	10
Interleukin-6 Downregulation	1	10
Antimicrobial	9	9
Chemoprotective Agents	7	9
NF-kappaB Inhibitor	7	8
Anti-Tumor	2	7
Anti-Angiogenic	4	6
Angiogenesis Inhibitors	4	5
Anti-Retroviral Agents	1	5
Cyclin D1 Down-Regulation	1	5
Immunomodulatory	4	5
Cyclooxygenase 2 Inhibitors	3	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Anticarcinogenic Agents	3	3
Antifungal Agents	2	3
Bcl-2 protein down-regulation	3	3
Cardioprotective	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	3
MicroRNA modulator	2	3
Neuroprotective Agents	3	3
Vascular Endothelial Growth Factor Inhibitors	2	3
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor	1	2
Antinoceceptive	1	2
Autophagy Up-regulation	1	2
Cyclooxygenase Inhibitors	1	2
Gastrointestinal Agents	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Interleukin-12 upregulation	1	2
Malondialdehyde Down-regulation	1	2
Radioprotective	2	2
Renoprotective	1	2
Survivin Down-Regulation	2	2
Tumor Suppressor Protein p53 Upregulation	2	2
apoptosis	1	2
Anti-Apoptotic	1	1
Anti-Ulcer Agents	1	1
Anticonvulsants	1	1
Appetite Stimulants	1	1
Bcl-xL down-regulation	1	1
Cytotoxic	1	1
Gastroprotective	1	1
Heat Shock Protein Inducer	1	1
Multidrug Resistance Gene Modulators	1	1
Nrf2 activation	1	1
P21 Activation	1	1
Photoprotective	1	1
Radiosensitizer	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
STAT3 Inhibitor	1	1
Superoxide Dismutase Up-regulation	1	1

[+]

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

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Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635

Article Published Date : Nov 30, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Cranberry, Curcumin, NAC (N-acetyl-L-cysteine)

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis

Additional Links

Substances : Peony

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Methotrexate

[+]

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Clin Psychopharmacol. 2015 Aug ;35(4):406-10. PMID: 26066335

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

Problem Substances : Antidepressants

[+]

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

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Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

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Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin, Vitamin D

Diseases : Breast Cancer, Breast Cancer: Metastatic, Chemotherapy-Induced Toxicity: Cyclophosphamide

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

[+]

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID: 26872471

Article Published Date : Feb 12, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

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Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1921-6. Epub 2014 Jul 22. PMID: 25070704

Article Published Date : Sep 30, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Cyanidin 3-glucoside

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-Tumor, Antiproliferative , apoptosis

Additional Keywords : Drug: Trastuzumab, Natural Substance/Drug Synergy, Supplements

[+]

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Pubmed Data : Drug Deliv. 2018 Nov ;25(1):1779-1789. PMID: 30338719

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Safflower

Diseases : Wound Healing

Pharmacological Actions : Angiogenesis Inducing Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

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Pubmed Data : J Appl Microbiol. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26442997

Article Published Date : Oct 06, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cryptococcosis

Pharmacological Actions : Antifungal Agents

Additional Keywords : Drug: Fluconazole, Natural Substance/Drug Synergy

[+]

Dandelion and lemongrass extracts were able to significantly reduce the tumour burden in prostate cancer xenograft models.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2951428. Epub 2019 Jul 17. PMID: 31391857

Article Published Date : Dec 31, 2018

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Pubmed Data : Front Pharmacol. 2019 ;10:1249. Epub 2019 Oct 25. PMID: 31708779

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : False Black Pepper

Diseases : Seizures: Drug-Induced

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

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Pubmed Data : Cancer Cell Int. 2019 ;19:68. Epub 2019 Mar 21. PMID: 30948928

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

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Pubmed Data : Pharm Biol. 2018 Dec ;56(1):455-464. PMID: 31070537

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Mangosteen

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-17 downregulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Additional Keywords : Natural Substance/Drug Synergy

[+]

Nordihydroguaiaretic acid enhances the activities of aminoglycosides against methicillin- sensitive and resistant Staphylococcus aureus.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2015 ;6:1195. Epub 2015 Oct 27. PMID: 26579101

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nordihydroguaiaretic acid (NDGA)

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Oleocanthal combined with lapatinib treatment synergized against HER-2 positive breast cancer.Feb 14, 2019

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Pubmed Data : Mol Carcinog. 2017 Mar 30. Epub 2017 Mar 30. PMID: 28370562

Article Published Date : Mar 29, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Malignant Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain.Jul 14, 2016

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Pubmed Data : Life Sci. 2016 Jul 15 ;157:25-31. Epub 2016 May 28. PMID: 27245275

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Pubmed Data : Mini Rev Med Chem. 2014 ;14(3):222-8. PMID: 24552263

Article Published Date : Dec 31, 2013

Study Type : Review

Additional Links

Substances : Parthenolide

Diseases : Cancers: All

Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Activity of allyl isothiocyanate and Its synergy with fluconazole against Candida albicans biofilms.Apr 27, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ascorbic acid synergistically potentiates phloxine b-induced photocytotoxicity in human acute promyelocytic leukemia cells.Mar 31, 2014

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Pubmed Data : J Biochem Mol Toxicol. 2014 Apr ;28(4):167-73. Epub 2014 Jan 31. PMID: 24488945

Article Published Date : Mar 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Oxidative Stress, Promyelocytic leukemia

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Assessment synergistic effects of integrated therapy with epigallocatechin-3-gallate & arsenic trioxide and irradiation on breast cancer cell line.Jul 31, 2020

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Beta-elemene potentiates the cytotoxic effects of various antineoplastic drugs in cell lines overexpressing the ABCB1 transporter.Jan 31, 2014

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Caffeic acid expands anti-tumor effect of Metformin in human metastatic cervical carcinoma HTB-34 cells.Feb 20, 2017

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Pubmed Data : Phytomedicine. 2017 Oct 15 ;34:85-96. Epub 2017 Aug 17. PMID: 28899514

Article Published Date : Oct 14, 2017

Study Type : In Vitro Study

Additional Links

Substances : Citral

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Co-administration of cytotoxic agents together with CBD increases drug uptake and potentiates cytotoxic activity in human glioma cells.Dec 31, 2012

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[+]

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells.Dec 31, 2019

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[+]

Curcumin ameliorates the targeted delivery of methotrexate intercalated montmorillonite clay to cancer cells.Jun 30, 2019

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Pubmed Data : Eur J Pharm Sci. 2019 Jul 1 ;135:91-102. Epub 2019 May 9. PMID: 31078644

Article Published Date : Jun 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cervical Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on drug-resistant carcinosarcoma cells.Jul 07, 2016

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Pubmed Data : Acta Biochim Pol. 2016 Jul 8. Epub 2016 Jul 8. PMID: 27390785

Article Published Date : Jul 07, 2016

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Carcinosarcomas

Pharmacological Actions : Anti-metastatic, Chemoprotective Agents, Cytotoxic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin can be used as a modulator which may have a potential therapeutic value for the treatment of retinoblastoma cancer patients.Dec 10, 2014

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Pubmed Data : Curr Eye Res. 2014 Dec 11:1-13. Epub 2014 Dec 11. PMID: 25495096

Article Published Date : Dec 10, 2014

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Retinoblastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin could enhance the effects of irinotecan on colorectal cancer cells.Apr 03, 2017

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Pubmed Data : Oncotarget. 2017 Apr 4. Epub 2017 Apr 4. PMID: 28402965

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View the Evidence: 471 Abstracts with Natural Substance/Drug Synergy Research

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A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Bee products are effective in symptomatic treatment of upper respiratory tract infections.Dec 31, 2019

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Clinical efficacy of acetylcysteine combined with tetrandrine tablets on patients with silicosis.Jul 31, 2020

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

The combined use of echinacea with azithromycin produced favourable outcome than azithromycin alone in pediatric patients with recurrent tonsillitis.Jul 31, 2020

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Hydrocortisone and ascorbic acid synergistically prevent and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.Jan 10, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.Jan 22, 2016

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma.Dec 31, 2019

The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice. Aug 23, 2020

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

Achillea fragrantissima, rich in flavonoids and tannins, potentiates the activity of diminazine aceturate against Trypanosoma evansi in rats.Feb 29, 2016

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK.Dec 31, 2016

An extract of Allspice was shown to be effective in decreasing the growth of MB231 tumors by oral administration, and this effect was greater when pretreated with AAE as a chemo-preventive agent.Apr 13, 2015

Anthocyanins work in synergy with trastuzumab by induced apoptosis, inhibited cell growth and affected HER2 downstream signaling.Sep 30, 2014

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Aspalathin from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic mice.Nov 13, 2018

Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.Jul 23, 2017

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Calcitriol enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction.Jul 24, 2016

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Chrysin strengthened the therapeutic efficacy of docetaxel and diminished the adverse effect of it.May 04, 2016

Cinnamaldehyde enhances antimelanoma activity through covalently binding ENO1 and exhibits a promoting effect with dacarbazine.Jan 28, 2020

Co-administration of carrot fruit significantly enhanced both ulcer preventive effects and ulcer healing properties of the pantoprazole.Nov 12, 2020

Co-administration of EGb 761 and donepezil exerted better anti-amnestic effect.Dec 24, 2020

Co-administration of hyperforin and lanicemine induces long-lasting antidepressant effects.Dec 31, 2017

Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis.Oct 31, 2018

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury.Dec 24, 2020

Combination of Rheum ribes and metformin against diabetes, thermal hyperalgesia, and tactile allodynia.Aug 31, 2018

Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.Jun 30, 2016

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.Dec 31, 2013

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Natural Substance/Drug Synergy

View the Evidence:
471 Abstracts with Natural Substance/Drug Synergy Research