Natural Substance/Drug Synergy

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15 Problem Substances Researched for Natural Substance/Drug Synergy
NameACCKFocus
Fluoxetine (trade name Prozac) 220Locked
Sertraline220Locked
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)211Locked
Antidepressants110Locked
Mesalamine110Locked
Simvastatin110Locked
Statin Drugs110Locked
Doxorubicin27Locked
Antibiotics44Locked
Cisplatin24Locked
Fluorouracil (5-FU or f5U) 12Locked
Nicotine12Locked
Paclitaxel12Locked
Prednisolone12Locked
Zoledronic Acid12Locked
117 Diseases Researched for Natural Substance/Drug Synergy
NameACCKFocus
Depression550Locked
Breast Cancer1734Locked
Colorectal Cancer733Locked
Helicobacter Pylori Infection523Locked
Depression: Postmenopausal220Locked
Cancers: All1318Locked
Oxidative Stress617Locked
Cancers: Drug Resistant815Locked
Rheumatoid Arthritis313Locked
Chronic Pain211Locked
Ulcerative Colitis211Locked
Acute lymphoblastic leukemia (ALL)110Locked
Anxiety Disorders110Locked
Atherosclerosis110Locked
Breast Cancer: Metastatic110Locked
C-Reactive Protein110Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide110Locked
Cholesterol: High110Locked
Colorectal Adenomas110Locked
Depressive Disorder110Locked
Drug-Induced Toxicity: Methotrexate110Locked
High Cholesterol110Locked
Peripheral Arterial Disease110Locked
Triglycerides: Elevated110Locked
Colon Cancer69Locked
Lung Cancer69Locked
Multiple Myeloma69Locked
Breast Cancer: Triple Negative 57Locked
Carcinoma: Non-Small-Cell Lung47Locked
Leukemia77Locked
Staphylococcus aureus: Methicillin-resistant (MRSA)77Locked
Gastric Cancer46Locked
Prostate Cancer56Locked
Arthritis35Locked
Breast Cancer Stem Cells15Locked
Breast Cancer: Drug Resistant15Locked
Ebola Virus Infections15Locked
Escherichia coli Infections55Locked
Pancreatic Cancer45Locked
Staphylococcus aureus infection55Locked
Allodynia24Locked
Lipid Peroxidation24Locked
Neuropathic Pain24Locked
Pseudomonas aeruginosa44Locked
Toxoplasma gondii Infection24Locked
Candida Albicans23Locked
Chemotherapy-Induced Toxicity23Locked
Esophageal Cancer23Locked
Inflammation23Locked
Liver Cancer23Locked
Melanoma23Locked
Acute Myeloid Leukemia22Locked
Candida Infection 22Locked
Candidiasis12Locked
Cardiotoxicity: Chemotherapy-Induced12Locked
Chemotherapy and Radiation Toxicity12Locked
Chemotherapy-Induced Toxicity: 5-fluorouracil 12Locked
Chemotherapy-Induced Toxicity: Cisplatin12Locked
Cognitive Decline/Dysfunction12Locked
Colitis12Locked
Cryptococcosis12Locked
Fibrosarcoma12Locked
Glioblastoma22Locked
Glioma22Locked
Gram-Negative Bacterial Infections22Locked
Hyperalgesia12Locked
Inflammatory Bowel Diseases12Locked
Kidney Cancer22Locked
Liver Metastasis From Colon Cancer12Locked
Malignant Melanoma12Locked
Memory Loss12Locked
Sepsis12Locked
Skin Cancer12Locked
Toxoplasmosis12Locked
AIDS11Locked
Alzheimer's Disease11Locked
Bacterial Infections: Resistance/Biofilm Formation11Locked
Bone Cancer11Locked
Brain Cancer11Locked
Breast Cancer: HER-2 Overexpressed11Locked
Cachexia: Cancer11Locked
Campylobacter Infections11Locked
Cancer Metastasis11Locked
Cancer: Pain 11Locked
Cancers: Multi-Drug Resistant11Locked
Carcinosarcomas11Locked
Cardiovascular Disease11Locked
Cervical Cancer11Locked
Chemotherapy11Locked
Chemotherapy-Induced Toxicity: Doxorubicin11Locked
Chemotherapy-Induced Toxicity: Tamoxifen11Locked
Chronic Lymphocytic Leukemia11Locked
Cystic Fibrosis11Locked
Diabesity 11Locked
Epilepsy11Locked
Epileptic Seizures11Locked
Fungal Infections: Biofilm Formation/Resistance11Locked
Glioblastoma Multiforme11Locked
Gram-Positive Bacterial Infections11Locked
Headache11Locked
Klebsiella Infections11Locked
Leukemia: Chronic myelogenous leukemia (CML) 11Locked
Melanoma: Metastatic11Locked
Mycobacterium tuberculosis11Locked
Neurofibromatosis11Locked
Non-Hodgkin's lymphoma: B Cell11Locked
Oral Cancer11Locked
Osteosarcoma11Locked
Parkinson's Disease11Locked
Periodontal Diseases11Locked
Peripheral Neuropathies11Locked
Radiation Induced Illness11Locked
Retinoblastoma11Locked
Rhabdomyosarcoma11Locked
Schwannoma11Locked
Squamous cell carcinoma11Locked
Streptococcus pyogenes 11Locked
118 Substances Researched for Natural Substance/Drug Synergy
NameACCKFocus
Curcumin2659Locked
Chinese Skullcap 221Locked
Astragalus120Locked
Hedyotis corymbosa120Locked
Soy220Locked
EGCG (Epigallocatechin gallate)713Locked
Silibinin413Locked
Vitamin D313Locked
Cannabis312Locked
Melatonin312Locked
Nigella sativa (aka Black Seed)212Locked
Fucoidan211Locked
Pomegranate211Locked
Quercetin1011Locked
Flaxseed110Locked
Lactobacillus reuteri110Locked
Lavender110Locked
Piperidines110Locked
Probiotics110Locked
Green Tea49Locked
Vitamin C58Locked
Catechin 37Locked
Gingerol 37Locked
Wogonin47Locked
Pterostilbene26Locked
6-Shogaol15Locked
Amurensin G15Locked
Cannabidiol 45Locked
Plantago major15Locked
Prunella vulgaris.15Locked
Resveratrol45Locked
Berberine44Locked
Cannabinoids 44Locked
Cannabinoids: Synthetic24Locked
Polyphenols44Locked
Sulforaphane34Locked
Turmeric44Locked
Anthocyanins23Locked
Honokiol33Locked
Olive leaf extract23Locked
Thymoquinone23Locked
Allspice12Locked
Banana12Locked
Beta-glucan12Locked
Black Tea22Locked
Capsaicin22Locked
Chrysin12Locked
Cyanidin 3-glucoside12Locked
Devils Claw12Locked
Emodin22Locked
Evening Primrose Oil12Locked
Garlic: Aged12Locked
Ginger22Locked
Luteolin12Locked
Magnolol22Locked
Maitake Mushroom12Locked
Mangiferin22Locked
Nobiletin 12Locked
Piperine22Locked
Puerarin12Locked
Resistant Starch12Locked
Vitamin E: alpha tocopherol12Locked
Allicin11Locked
Aloe Vera11Locked
Antrodia cinnamomea 11Locked
Asparagus11Locked
Baicalein11Locked
Basil11Locked
Beans: All 11Locked
Bee Venom11Locked
Beet11Locked
Bergamot orange11Locked
Bitter Melon11Locked
Black Currant11Locked
Blueberry11Locked
Cafestol11Locked
Cayenne11Locked
Celery seed11Locked
Chokeberry11Locked
Citrus naringin11Locked
Cruciferous Vegetables11Locked
Cucurbitacin B 11Locked
Echinacea11Locked
Erucin11Locked
Fruit: All11Locked
Fucoxanthin 11Locked
Genistein11Locked
Ginseng (Korean)11Locked
Ginsenosides11Locked
Glycyrrhizin11Locked
Grape11Locked
Grape Seed Extract11Locked
Hesperidin11Locked
Hibiscus sabdariffa 11Locked
Indole-3-Carbinol11Locked
Isothiocyanates11Locked
Lutein11Locked
Magnolia11Locked
Manuka Honey11Locked
Maple Syrup11Locked
Modified Arabinoxylan Rice Bran (MGN-3)11Locked
Plum11Locked
Rice Bran11Locked
Seaweed: Brown 11Locked
Silver (nanoparticles)11Locked
Silymarin11Locked
Tangeretin 11Locked
Theaflavins11Locked
Tocotrienols11Locked
Tomato11Locked
Vanillin11Locked
Vegetables: All 11Locked
Vitamin E: Gamma-tocotrienol11Locked
Vitamin K11Locked
Watercress11Locked
Wheat Grass11Locked
Zinc11Locked
beta-Carotene11Locked
1 Therapeutic Actions Researched for Natural Substance/Drug Synergy
NameACCKFocus
Integrative Medicine23Locked
69 Pharmacological Actions Researched for Natural Substance/Drug Synergy
NameACCKFocus
Apoptotic4871Locked
Antiproliferative 4769Locked
Antidepressive Agents550Locked
Chemosensitizer2244Locked
Anti-Inflammatory Agents1335Locked
Antioxidants1531Locked
Chemotherapeutic1427Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor424Locked
Antineoplastic Agents1319Locked
Anti-Bacterial Agents1616Locked
Analgesics515Locked
Chemopreventive915Locked
Anti-metastatic1113Locked
Cell cycle arrest1012Locked
Hepatoprotective212Locked
Interleukin-1 beta downregulation212Locked
Interleukin-8 downregulation211Locked
Anti-atherogenic110Locked
Anticholesteremic Agents110Locked
Hypolipidemic110Locked
Interleukin-6 Downregulation110Locked
Antimicrobial99Locked
Chemoprotective Agents79Locked
NF-kappaB Inhibitor78Locked
Anti-Tumor27Locked
Anti-Angiogenic46Locked
Angiogenesis Inhibitors45Locked
Anti-Retroviral Agents15Locked
Cyclin D1 Down-Regulation15Locked
Immunomodulatory45Locked
Cyclooxygenase 2 Inhibitors34Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor34Locked
Anticarcinogenic Agents33Locked
Antifungal Agents23Locked
Bcl-2 protein down-regulation33Locked
Cardioprotective23Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor23Locked
MicroRNA modulator23Locked
Neuroprotective Agents33Locked
Vascular Endothelial Growth Factor Inhibitors23Locked
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor12Locked
Antinoceceptive 12Locked
Autophagy Up-regulation12Locked
Cyclooxygenase Inhibitors12Locked
Gastrointestinal Agents12Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor12Locked
Interleukin-12 upregulation12Locked
Malondialdehyde Down-regulation12Locked
Radioprotective22Locked
Renoprotective12Locked
Survivin Down-Regulation22Locked
Tumor Suppressor Protein p53 Upregulation22Locked
apoptosis12Locked
Anti-Apoptotic11Locked
Anti-Ulcer Agents11Locked
Anticonvulsants11Locked
Appetite Stimulants11Locked
Bcl-xL down-regulation11Locked
Cytotoxic11Locked
Gastroprotective11Locked
Heat Shock Protein Inducer11Locked
Multidrug Resistance Gene Modulators11Locked
Nrf2 activation11Locked
P21 Activation11Locked
Photoprotective11Locked
Radiosensitizer11Locked
Reactive Oxygen Species (ROS) attenuation11Locked
STAT3 Inhibitor11Locked
Superoxide Dismutase Up-regulation11Locked

View the Evidence:
378 Abstracts with Natural Substance/Drug Synergy Research

[+]

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635
Article Published Date : Nov 30, 2018
Study Type : Meta Analysis, Review
Additional Links
Substances : Cranberry, Curcumin, NAC (N-acetyl-L-cysteine)
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents, Antioxidants
Additional Keywords : Natural Substance/Drug Synergy
[+]

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242
Article Published Date : Dec 31, 2018
Study Type : Meta Analysis
Additional Links
Substances : Peony
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Methotrexate
[+]

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

Pubmed Data : Integr Cancer Ther. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26254190
Article Published Date : Aug 05, 2015
Study Type : Meta Analysis
Additional Links
Substances : Astragalus, Chinese Skullcap , Hedyotis corymbosa
Diseases : Colorectal Cancer
Additional Keywords : Drug: Oxaliplatin, Natural Substance/Drug Synergy
[+]

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

Pubmed Data : Infect Drug Resist. 2016 ;9:275-289. Epub 2016 Dec 7. PMID: 27994474
Article Published Date : Dec 31, 2015
Study Type : Meta Analysis
Additional Links
Substances : Probiotics
Diseases : Diarrhea: Antibiotic-Associated, Helicobacter Pylori Infection
Pharmacological Actions : Gastroprotective
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Antibiotics
[+]

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2011 Mar ;2(2):319-322. Epub 2011 Jan 21. PMID: 22866084
Article Published Date : Feb 28, 2011
Study Type : Human Study
Additional Links
Substances : Fucoidan
Diseases : Colorectal Adenomas
Pharmacological Actions : Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Electron Physician. 2016 Aug ;8(8):2818-2827. Epub 2016 Aug 25. PMID: 27757195
Article Published Date : Jul 31, 2016
Study Type : Human Study
Additional Links
Substances : Barberry
Diseases : Bacterial Vaginosis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2017 Mar-Apr;7(2):129-136. PMID: 28348968
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Substances : Myrtle
Diseases : Bacterial Vaginosis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2012 Nov 21 ;18(43):6302-7. PMID: 23180952
Article Published Date : Nov 20, 2012
Study Type : Human Study
Additional Links
Substances : Probiotics
Diseases : Helicobacter Pylori Infection
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pak J Med Sci. 2018 May-Jun;34(3):616-620. PMID: 30034426
Article Published Date : Apr 30, 2018
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Prunella vulgaris
Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Urinary Tract Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Renal Inj Prev. 2017 ;6(2):127-131. Epub 2016 Dec 18. PMID: 28497089
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Syrian rue
Diseases : Prostatic Hyperplasia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Natural Substance/Drug Synergy
[+]

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Pubmed Data : Infect Disord Drug Targets. 2015 Mar 20. Epub 2015 Mar 20. PMID: 25809628
Article Published Date : Mar 19, 2015
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acute lymphoblastic leukemia (ALL), Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Chemotherapeutic, Hepatoprotective
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Pubmed Data : Drug Alcohol Depend. 2015 Feb 1 ;147:144-50. Epub 2014 Dec 10. PMID: 25533893
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Substances : Cannabis
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Pubmed Data : J Clin Psychopharmacol. 2015 Aug ;35(4):406-10. PMID: 26066335
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome
Problem Substances : Antidepressants
[+]

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cochrane Database Syst Rev. 2012 ;10:CD008424. Epub 2012 Oct 17. PMID: 23076948
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Ulcerative Colitis
Additional Keywords : Complementary Alternative Medicine, Natural Substance/Drug Synergy, Randomized Controlled Trials As Topic
Problem Substances : Mesalamine, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Pubmed Data : Phytother Res. 2015 Jan ;29(1):17-21. Epub 2014 Aug 4. PMID: 25091591
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Curcumin, Piperidines
Diseases : Anxiety Disorders, Depression, Depressive Disorder
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2012 Nov 21 ;18(43):6250-4. PMID: 23180945
Article Published Date : Nov 20, 2012
Study Type : Human Study
Additional Links
Substances : Lactobacillus reuteri
Diseases : Helicobacter Pylori Infection
Additional Keywords : Natural Substance/Drug Synergy
[+]

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Pubmed Data : Iran Red Crescent Med J. 2013 Aug ;15(8):734-9. Epub 2013 Aug 5. PMID: 24578844
Article Published Date : Jul 31, 2013
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

Pubmed Data : J Nutr. 2015 Apr ;145(4):749-57. Epub 2015 Feb 18. PMID: 25694068
Article Published Date : Mar 31, 2015
Study Type : Human Study
Additional Links
Substances : Flaxseed
Diseases : Cholesterol: High, Peripheral Arterial Disease
Pharmacological Actions : Anticholesteremic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:806. Epub 2018 Aug 3. PMID: 30123125
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Prunella vulgaris
Diseases : Breast Cancer
Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238
Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Substances : Silibinin
Diseases : C-Reactive Protein, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Substances : Melatonin, Vitamin D
Diseases : Breast Cancer, Breast Cancer: Metastatic, Chemotherapy-Induced Toxicity: Cyclophosphamide
Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome
[+]

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

Pubmed Data : Atherosclerosis. 2014 Jan ;232(1):204-10. Epub 2013 Nov 19. PMID: 24401239
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Pomegranate
Diseases : Atherosclerosis, High Cholesterol, Oxidative Stress, Triglycerides: Elevated
Pharmacological Actions : Anti-atherogenic, Antioxidants, Hypolipidemic
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
Problem Substances : Simvastatin, Statin Drugs
[+]

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653
Article Published Date : Feb 28, 2014
Study Type : Human Study
Additional Links
Substances : Soy
Diseases : Depression, Depression: Postmenopausal
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Fluoxetine (trade name Prozac) , Sertraline
[+]

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653
Article Published Date : Feb 28, 2014
Study Type : Human Study
Additional Links
Substances : Soy
Diseases : Depression, Depression: Postmenopausal
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Fluoxetine (trade name Prozac) , Sertraline
[+]

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

Pubmed Data : Pharmacol Res. 2019 Mar ;141:392-396. Epub 2019 Jan 9. PMID: 30639384
Article Published Date : Feb 28, 2019
Study Type : Human Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Ovarian Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Ital Urol Androl. 2016 Oct 5 ;88(3):177-182. Epub 2016 Oct 5. PMID: 27711089
Article Published Date : Oct 04, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain, Lycopene, Saw Palmetto, Selenium
Diseases : Prostatitis: Bacterial
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711
Article Published Date : Mar 10, 2015
Study Type : Human In Vitro
Additional Links
Substances : 6-Shogaol, Gingerol , Pterostilbene
Diseases : Breast Cancer, Breast Cancer Stem Cells
Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Pharmacol. 2010 Nov ;78(5):855-64. Epub 2010 Aug 16. PMID: 20713551
Article Published Date : Oct 31, 2010
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Amurensin G
Diseases : Breast Cancer: Drug Resistant, Cancers: Drug Resistant
Pharmacological Actions : Chemosensitizer
Additional Keywords : Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts
Problem Substances : Doxorubicin
[+]

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Pubmed Data : J Cancer Res Clin Oncol. 2015 Sep ;141(9):1511-22. Epub 2014 Dec 28. PMID: 25544670
Article Published Date : Aug 31, 2015
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate), Green Tea
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Pubmed Data : Br J Nutr. 2012 Jun ;107(11):1591-602. Epub 2011 Sep 29. PMID: 22018732
Article Published Date : Jun 01, 2012
Study Type : Human In Vitro
Additional Links
Substances : Plantago major
Diseases : Colorectal Cancer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Pubmed Data : Biomed Pharmacother. 2017 Nov 20. Epub 2017 Nov 20. PMID: 29169726
Article Published Date : Nov 19, 2017
Study Type : Human In Vitro
Additional Links
Substances : Piperine
Diseases : Cervical Cancer
Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Pubmed Data : Antiviral Res. 2016 Mar ;127:20-31. Epub 2016 Jan 9. PMID: 26778707
Article Published Date : Feb 29, 2016
Study Type : Human In Vitro
Additional Links
Substances : Prunella vulgaris
Diseases : Ebola Virus Infections
Pharmacological Actions : Anti-Retroviral Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Nov 8 ;7(45):73200-73215. PMID: 27689322
Article Published Date : Nov 07, 2016
Study Type : Human In Vitro
Additional Links
Substances : Pterostilbene
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gefitinib, Natural Substance/Drug Synergy
[+]

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharmacol. 2016 Nov-Dec;48(6):637-642. PMID: 28066099
Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Genistein
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer
Additional Keywords : Breast Cancer, Breast Cancer: Triple Negative, Chemosensitizer, Genistein, Natural Substance/Drug Synergy, Selective Cytotoxicity
[+]

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(4):e0154159. Epub 2016 Apr 21. PMID: 27101369
Article Published Date : Dec 31, 2015
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Deguelin
Diseases : Chronic Lymphocytic Leukemia
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Access Maced J Med Sci. 2015 Jun 15 ;3(2):331-6. Epub 2015 Jun 2. PMID: 27275246
Article Published Date : Jun 14, 2015
Study Type : Human: Case Report
Additional Links
Substances : Beet, Carrot
Diseases : Leukemia: Chronic Lymphocytic Leukemia (CLL)
Pharmacological Actions : Chemopreventive, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1 ;309(3):R223-34. PMID: 25994956
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Candida Albicans, Candidiasis, Sepsis
Pharmacological Actions : Renoprotective
Additional Keywords : Natural Substance/Drug Synergy
[+]

Achillea fragrantissima, rich in flavonoids and tannins, potentiates the activity of diminazine aceturate against Trypanosoma evansi in rats.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):228-34. Epub 2016 Jan 11. PMID: 26972392
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Achillea fragrantissima
Diseases : Parasitic Diseases
Pharmacological Actions : Antiparasitic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID: 26872471
Article Published Date : Feb 12, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Glioblastoma
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
[+]

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacognosy Res. 2013 Jul ;5(3):189-94. PMID: 23901215
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Garlic: Aged
Diseases : Fibrosarcoma
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(8):e0183003. Epub 2017 Aug 14. PMID: 28806414
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin E: alpha tocopherol
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

An extract of Allspice was shown to be effective in decreasing the growth of MB231 tumors by oral administration, and this effect was greater when pretreated with AAE as a chemo-preventive agent.Apr 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Apr 14. Epub 2015 Apr 14. PMID: 25945840
Article Published Date : Apr 13, 2015
Study Type : Animal Study
Additional Links
Substances : Allspice
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : AKT-mammalian target of rapamycin (mTOR) pathway inhibitor, Apoptotic, Autophagy Up-regulation, Chemopreventive
Additional Keywords : Dietary Concentrations, Drug: Rapamycin, Natural Substance/Drug Synergy
[+]

Anthocyanins work in synergy with trastuzumab by induced apoptosis, inhibited cell growth and affected HER2 downstream signaling.Sep 30, 2014

Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1921-6. Epub 2014 Jul 22. PMID: 25070704
Article Published Date : Sep 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Anthocyanins, Cyanidin 3-glucoside
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-Tumor, Antiproliferative , apoptosis
Additional Keywords : Drug: Trastuzumab, Natural Substance/Drug Synergy, Supplements
[+]

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2016 11 ;9(11):1084-1088. Epub 2016 Oct 22. PMID: 27890369
Article Published Date : Jan 10, 2016
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Antimicrob Chemother. 2012 Feb ;67(2):452-9. Epub 2011 Nov 28. PMID: 22127588
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Renoprotective
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Antibiotics
[+]

Aspalathin from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic mice.Nov 13, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2018 Nov 14 ;67(5):813-818. Epub 2018 Jul 25. PMID: 30044119
Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Rooibos
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.Jul 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 Jul 24 ;42(4):1657-1669. Epub 2017 Jul 24. PMID: 28738346
Article Published Date : Jul 23, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Cancer. 2004 Apr 19 ;90(8):1672-8. PMID: 15083202
Article Published Date : Apr 18, 2004
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancer Metastasis, Melanoma, Skin Cancer
Pharmacological Actions : Anti-metastatic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Calcitriol enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction.Jul 24, 2016

Pubmed Data : Mol Cancer Ther. 2016 Jul 25. Epub 2016 Jul 25. PMID: 27458137
Article Published Date : Jul 24, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Feb 24 ;18(3). Epub 2017 Feb 24. PMID: 28245556
Article Published Date : Feb 23, 2017
Study Type : Animal Study
Additional Links
Substances : Chrysanthemum Indicum
Diseases : Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Chrysin strengthened the therapeutic efficacy of docetaxel and diminished the adverse effect of it.May 04, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2016 May 5. Epub 2016 May 5. PMID: 27151585
Article Published Date : May 04, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Chrysin
Diseases : Carcinoma: Non-Small-Cell Lung, Chemotherapy and Radiation Toxicity, Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemoprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Diclofenac
[+]

Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2014 ;15(9):16284-301. Epub 2014 Sep 15. PMID: 25226537
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic
Additional Keywords : Drug: Mitomycin, Natural Substance/Drug Synergy
[+]

Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.Jun 30, 2016

Pubmed Data : J Med Assoc Thai. 2016 Jul ;99 Suppl 4:S23-31. PMID: 29916670
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Cervical Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Angiogenic, Apoptotic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Pubmed Data : Planta Med. 2014 Apr ;80(6):452-7. Epub 2014 Mar 31. PMID: 24687742
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Drug: Carboplatin, Natural Substance/Drug Synergy, Plant Extracts
[+]

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.Dec 31, 2013

Pubmed Data : J Pharm Pharmacol. 2014 Jan ;66(1):133-44. Epub 2013 Oct 21. PMID: 24138213
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Pubmed Data : Zhong Yao Cai. 2014 Oct ;37(10):1833-6. PMID: 25895394
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Corn Silk
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Chemotherapeutic Agent: Cyclophosphamide, Natural Substance/Drug Synergy, Polysaccharides
[+]

Curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetol Metab Syndr. 2019 ;11:33. Epub 2019 Apr 30. PMID: 31061679
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Dyslipidemias, Hyperglycemia
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin enhances the activity of fluconazole against Cryptococcus gattii-induced cryptococcosis infection in mice.Oct 06, 2015

Pubmed Data : J Appl Microbiol. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26442997
Article Published Date : Oct 06, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cryptococcosis
Pharmacological Actions : Antifungal Agents
Additional Keywords : Drug: Fluconazole, Natural Substance/Drug Synergy
[+]

Dandelion and lemongrass extracts were able to significantly reduce the tumour burden in prostate cancer xenograft models.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2951428. Epub 2019 Jul 17. PMID: 31391857
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Dandelion , Lemongrass
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy, Selective Cytotoxicity
[+]

Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.Mar 31, 2015

Pubmed Data : Behav Pharmacol. 2015 Apr ;26(3):304-14. PMID: 25485642
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence.Oct 14, 2014

Pubmed Data : Eur J Pharmacol. 2014 Oct 15 ;741:272-80. Epub 2014 Aug 30. PMID: 25179576
Article Published Date : Oct 14, 2014
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Morphine Tolerance/Dependence
Additional Keywords : Natural Substance/Drug Synergy
[+]

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

Evening primrose oil significantly reduced the synovial hyperplasia and inflammatory cells invasion in joint tissues.Sep 30, 2014

Pubmed Data : Inflammopharmacology. 2014 Oct ;22(5):305-17. Epub 2014 Mar 25. PMID: 24664592
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Evening Primrose Oil
Diseases : Arthritis, Inflammation, Lipid Peroxidation, Oxidative Stress, Rheumatoid Arthritis
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Flos Lonicera and metformin in combination exerts a synergistic effect on the improvement of hepatosteatosis and insulin sensitivity.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2017 ;8:2271. Epub 2017 Nov 17. PMID: 29204141
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Honeysuckle
Diseases : Diabetes Mellitus: Type 2, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypoglycemic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Gentamicin in combination with ascorbic acid regulates the severity of Staphylococcus aureus infection-induced septic arthritis in mice.Nov 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Scand J Immunol. 2012 Dec ;76(6):528-40. PMID: 22924656
Article Published Date : Nov 30, 2012
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Oxidative Stress, Staphylococcus aureus infection
Pharmacological Actions : Antioxidants, Interferon Gamma Reducer, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Antioxidants, Natural Substance/Drug Synergy, oxidative stress, Staphylococcus aureus infection, Vitamin C
[+]

Ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo.Oct 04, 2014

Pubmed Data : Eur J Pharmacol. 2014 Oct 5 ;740:277-84. Epub 2014 Jul 20. PMID: 25054686
Article Published Date : Oct 04, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

Pubmed Data : Chin Med J (Engl). 2007 Apr 5 ;120(7):584-8. PMID: 17442207
Article Published Date : Apr 04, 2007
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Ovarian Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

H. procumbens cooperates synergistically with morphine in resolving hyperalgesia and allodynia.May 31, 2016

Pubmed Data : Nat Prod Res. 2016 Jun ;30(11):1248-55. Epub 2015 Jul 20. PMID: 26189616
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Devils Claw
Diseases : Allodynia, Hyperalgesia, Neuropathic Pain
Additional Keywords : Natural Substance/Drug Synergy
[+]

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.Jan 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Proc Natl Acad Sci U S A. 2020 Jan 7. Epub 2020 Jan 7. PMID: 31911474
Article Published Date : Jan 06, 2020
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Lymphoma: B-Cell
Pharmacological Actions : Chemotherapeutic, Immunomodulatory
Additional Keywords : Natural Substance/Drug Synergy
[+]

HU-331 was more active on cancer growth and less toxic for the tumor-bearing host than doxorubicin.Jul 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2007 Aug ;322(2):646-53. Epub 2007 May 3. PMID: 17478614
Article Published Date : Jul 31, 2007
Study Type : Animal Study
Additional Links
Substances : Cannabinoids: Synthetic
Diseases : Cancers: All, Lipid Peroxidation
Pharmacological Actions : Antineoplastic Agents, Malondialdehyde Down-regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Lactoferrin modified daunorubicin plus honokiol liposomes could be used as a potential therapy for treatment of brain glioma.Jun 02, 2017

Pubmed Data : Eur J Pharm Sci. 2017 Jun 3 ;106:185-197. Epub 2017 Jun 3. PMID: 28583810
Article Published Date : Jun 02, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Glioma
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Drug: Daunorubicin, Natural Substance/Drug Synergy
[+]

Luteolin could restore sensitivity of oxaliplatin resistant cell lines to chemotherapeutic drugs.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2014 ;15(6):2911-6. PMID: 24761924
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Drug: Oxaliplatin, Natural Substance/Drug Synergy
[+]

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2019 ;19:68. Epub 2019 Mar 21. PMID: 30948928
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Lung Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2018 Dec ;56(1):455-464. PMID: 31070537
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Mangosteen
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-17 downregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Melatonin augments the effects of fluoxetine on depression.Oct 30, 2017

Pubmed Data : Neurosci Bull. 2017 Oct 31. Epub 2017 Oct 31. PMID: 29086908
Article Published Date : Oct 30, 2017
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
Additional Keywords : Natural Substance/Drug Synergy
[+]

Metformin in combination with curcumin inhibits the growth, metastasis and angiogenesis of hepatocellular carcinoma.Aug 18, 2017

Pubmed Data : Mol Carcinog. 2017 Aug 19. Epub 2017 Aug 19. PMID: 28833603
Article Published Date : Aug 18, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.Mar 31, 2007

Pubmed Data : Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2):349-54. PMID: 17624247
Article Published Date : Mar 31, 2007
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Oseltamivir (trade name Tamiflu)
[+]

Nardostachys jatamansi root extract could increase in the protective index of phenytoin.Nov 30, 2005

Pubmed Data : J Ethnopharmacol. 2005 Dec 1 ;102(3):351-6. Epub 2005 Aug 10. PMID: 16095854
Article Published Date : Nov 30, 2005
Study Type : Animal Study
Additional Links
Substances : Spikenard
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 May ;13(5):2193-2202. Epub 2017 Mar 28. PMID: 28565827
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Nordihydroguaiaretic acid enhances the activities of aminoglycosides against methicillin- sensitive and resistant Staphylococcus aureus.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2015 ;6:1195. Epub 2015 Oct 27. PMID: 26579101
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nordihydroguaiaretic acid (NDGA)
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Oleocanthal combined with lapatinib treatment synergized against HER-2 positive breast cancer.Feb 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Feb 15 ;11(2). Epub 2019 Feb 15. PMID: 30781364
Article Published Date : Feb 14, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oleocanthal
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.Aug 01, 2019

Pubmed Data : Cell Oncol (Dordr). 2019 Aug 2. Epub 2019 Aug 2. PMID: 31376137
Article Published Date : Aug 01, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Breast Cancer, Ovarian Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Pioglitazone plus nettle has synergistic protective effects against STZ-induced nephropathy.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2017 May ;20(5):497-502. PMID: 28656084
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Renoprotective
Additional Keywords : Natural Substance/Drug Synergy
[+]

Propolis acted synergistically with cefixime and enhanced the efficacy of antibiotic and reduced its effective dose in combined therapy.Nov 24, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Nov 25 ;16(1):485. Epub 2016 Nov 25. PMID: 27887651
Article Published Date : Nov 24, 2016
Study Type : Animal Study
Additional Links
Substances : Bee Propolis
Diseases : Salmonella Infections
Additional Keywords : Medication Reduction, Natural Substance/Drug Synergy
[+]

Puerarin and 5 FU combined exhibited a significantly greater effect than either drug alone, with the tumor inhibition rate reaching 89.06%.Oct 31, 2014

Pubmed Data : Mol Med Rep. 2014 Nov ;10(5):2535-41. Epub 2014 Sep 5. PMID: 25189132
Article Published Date : Oct 31, 2014
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Drug: 5-flourouracil, Natural Substance/Drug Synergy
[+]

Quercetin could be a favourable antifungal agent and a promising synergist with fluconazole.Nov 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 Nov 30 ;40(3-4):727-742. Epub 2016 Nov 30. PMID: 27915337
Article Published Date : Nov 29, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Candida Albicans, Candidiasis: Vulvovaginal
Pharmacological Actions : Antifungal Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Quercetin enhances the antitumor effect of trichostatin A and prevents its induced muscle wasting.Jan 01, 2018

Pubmed Data : Food Funct. 2018 Jan 2. Epub 2018 Jan 2. PMID: 29292417
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Cachexia: Cancer, Lung Cancer
Pharmacological Actions : Anti-Cachexic Agents, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Quercetin has anti-myeloma activity both in vitro and in vivo.Jun 13, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Jun 14. Epub 2016 Jun 14. PMID: 27329589
Article Published Date : Jun 13, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Drug: Dexamethasone, Natural Substance/Drug Synergy
[+]

Resistance to cetuximab in human colon cancer patients with a mutant KRAS can be bypassed by L-ascorbic acid in an SVCT-2-dependent manner.Mar 21, 2016

Pubmed Data : Free Radic Biol Med. 2016 Mar 22 ;95:200-208. Epub 2016 Mar 22. PMID: 27012422
Article Published Date : Mar 21, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Cancers: Drug Resistant, Colon Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Resveratrol improved the effect of sulfamethoxazole-trimethoprim in reducing oxidative damage, liver damage and the number of cysts in the brain.Apr 03, 2016

Pubmed Data : Microb Pathog. 2016 Apr 4 ;95:166-174. Epub 2016 Apr 4. PMID: 27057672
Article Published Date : Apr 03, 2016
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Toxoplasma gondii Infection
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Natural Substance/Drug Synergy
[+]

Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Leukoc Biol. 2015 Dec ;98(6):1015-25. Epub 2015 Aug 21. PMID: 26297795
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Beta-glucan, Maitake Mushroom
Diseases : Colon Cancer
Pharmacological Actions : Immunomodulatory, Interleukin-12 upregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Supplementation of vitamin E may improve the efficacy of standard and experimental cancer therapies by subsiding the toxic effect of the antineoplastic agent.Mar 31, 2015

Pubmed Data : Hum Exp Toxicol. 2015 Apr ;34(4):380-9. Epub 2014 Oct 10. PMID: 25304969
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin E: alpha tocopherol
Diseases : Cardiotoxicity: Chemotherapy-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats.Dec 01, 2017

Pubmed Data : J Cell Physiol. 2017 Dec 2. Epub 2017 Dec 2. PMID: 29205344
Article Published Date : Dec 01, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Diabetes Mellitus: Type 2
Additional Keywords : Natural Substance/Drug Synergy
[+]

Synergistic combination of N-acetylcysteine and ribavirin to protect from lethal influenza viral infection in a mouse model.Dec 31, 2003

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2004 Jan-Apr;17(1):99-102. PMID: 15000873
Article Published Date : Dec 31, 2003
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Influenza A
Pharmacological Actions : Antioxidants, Antiviral Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2019 ;10(26):6543-6556. Epub 2019 Oct 21. PMID: 31777584
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

The addition of curcumin to FOLFOX based chemotherapy enhances efficacy in patient derived CRLM cultures.Aug 09, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Lett. 2015 Aug 10 ;364(2):135-41. Epub 2015 May 12. PMID: 25979230
Article Published Date : Aug 09, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer, Liver Metastasis From Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Drug: Oxaliplatin, Natural Substance/Drug Synergy
[+]

The administration of EGCG after sunitinib treatment represents a promising strategy for the treatment of cancer.Jan 04, 2016

Pubmed Data : Tumour Biol. 2016 Jan 5. Epub 2016 Jan 5. PMID: 26733173
Article Published Date : Jan 04, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Breast Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

The combination of auranofin and vitamin C could be efficient against triple-negative breast cancer.Nov 19, 2018

Pubmed Data : J Natl Cancer Inst. 2018 Nov 20. Epub 2018 Nov 20. PMID: 30462268
Article Published Date : Nov 19, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

The combination of CS plus metronomic ZOL demonstrated significant antitumor, anti-metastatic and anti-osteolytic effects against breast cancerMay 19, 2015

Pubmed Data : Oncol Rep. 2015 May 20. Epub 2015 May 20. PMID: 25998578
Article Published Date : May 19, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Green Tea
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Zoledronic Acid
[+]

The combination of nigella sativa oil and pyrimethamine had a synergistic effect in the treatment of toxoplasmosis.Oct 06, 2015

Pubmed Data : Parasitol Res. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26446086
Article Published Date : Oct 06, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Toxoplasma gondii Infection, Toxoplasmosis
Therapeutic Actions : Integrative Medicine
Pharmacological Actions : Antioxidants
Additional Keywords : Natural Substance/Drug Synergy
[+]

The combination of pomegranate juice and tolbutamide exhibited profound protection compared to tolbutamide alone against diabetic complications.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Med Res. 2017 Dec ;6(4):354-360. Epub 2017 Aug 1. PMID: 29296562
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Diabetic Complications
Pharmacological Actions : Antinoceceptive
Additional Keywords : Natural Substance/Drug Synergy
[+]

the combination of vitamin C with benznidazole could be considered as an alternative treatment for Chagas' disease.Sep 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS Negl Trop Dis. 2018 Sep 21 ;12(9):e0006764. Epub 2018 Sep 21. PMID: 30240395
Article Published Date : Sep 20, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Chagas Disease
Pharmacological Actions : Antiparasitic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

The dietary use of the green dwarf banana flour constitutes an important dietary supplement and complementary medicine product for the prevention and treatment of human inflammatory bowel disease.Feb 29, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res. 2012 Mar ;32(3):202-9. PMID: 22464807
Article Published Date : Feb 29, 2012
Study Type : Animal Study
Additional Links
Substances : Banana, Resistant Starch
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents
Additional Keywords : Dietary Modification, Natural Substance/Drug Synergy
Problem Substances : Prednisolone
[+]

The overall results suggest that combination of mangiferin with both metformin and gliclazide alleviates diabetic conditions.Mar 21, 2019

Pubmed Data : Phytomedicine. 2019 Mar 22 ;59:152901. Epub 2019 Mar 22. PMID: 30981189
Article Published Date : Mar 21, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

The results of this study indicate that dry olive leaf extract possesses strong antimelanoma potential.Apr 14, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID: 20568104
Article Published Date : Apr 14, 2011
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Chemotherapy-Induced Toxicity, Malignant Melanoma, Melanoma, Skin Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Antagonism, Natural Substance/Drug Synergy, Plant Leaves, Temozolomide
Problem Substances : Cisplatin, Doxorubicin, Paclitaxel
[+]

Theanine significantly enhanced the repression of liver cancer cell growth in combination with anticancer drug pirarubicin.Sep 08, 2016

Pubmed Data : J Agric Food Chem. 2016 Sep 9. Epub 2016 Sep 9. PMID: 27569455
Article Published Date : Sep 08, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Theanine
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

There is a close interaction between curcumin and cholinergic system, and curcumin may have protective effects on cholinergic system.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Apr ;18(4):398-403. PMID: 26019804
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cognitive Decline/Dysfunction, Memory Loss
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Nicotine
[+]

There was a synergistic and potentiating effect of grapefruit juice and aripriprazole.Mar 22, 2018

Pubmed Data : BMC Complement Altern Med. 2018 Mar 23 ;18(1):106. Epub 2018 Mar 23. PMID: 29566693
Article Published Date : Mar 22, 2018
Study Type : Animal Study
Additional Links
Substances : Grapefruit
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Natural Substance/Drug Synergy
[+]

These data suggest that the gabapentin and mangiferin combination produces a synergistic interaction at the peripheral level.Nov 30, 2017

Pubmed Data : Drug Dev Res. 2017 Dec ;78(8):390-402. Epub 2017 Sep 20. PMID: 28940250
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Neuropathic Pain
Additional Keywords : Mangiferin, Natural Substance/Drug Synergy, Neuropathic Pain
[+]

These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic neuropathic pain.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:711. Epub 2019 Jun 27. PMID: 31316381
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Carnosic Acid, Myrrh, Palmitoylethanolamide
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

These results demonstrate that parthenolide potentiates the efficacy of balsalazide.Jan 31, 2017

Pubmed Data : Mol Cancer Res. 2017 Feb ;15(2):141-151. Epub 2016 Nov 14. PMID: 28108625
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

This study demonstrated the results of interactions between ascorbic acid and tramadol or morphine.Jul 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anesth Pain Med. 2014 Aug ;4(3):e19529. Epub 2014 Jun 22. PMID: 25289375
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Pharmacological Actions : Analgesics, Antinoceceptive
Additional Keywords : Dose Response, Natural Substance/Drug Synergy
[+]

This study established a new mechanism for using EGCG as an adjuvant chemotherapy agent through modifying microvasculature and microenvironments. Apr 30, 2013

Pubmed Data : Chin J Nat Med. 2013 May ;11(3):245-53. PMID: 23725836
Article Published Date : Apr 30, 2013
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Carcinoma: Non-Small-Cell Lung, Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer
Pharmacological Actions : Anti-Angiogenic, Antineoplastic Agents, Antiproliferative , Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Cisplatin
[+]

This study highlights the potential therapeutic usefulness of curcumin as an adjunct in patients with chemoresistant advanced CRC. Feb 28, 2015

Pubmed Data : Carcinogenesis. 2015 Mar ;36(3):355-67. Epub 2015 Feb 4. PMID: 25653233
Article Published Date : Feb 28, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: Drug Resistant, Chemotherapy-Induced Toxicity: 5-fluorouracil , Colorectal Cancer
Pharmacological Actions : Chemosensitizer, MicroRNA modulator
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Fluorouracil (5-FU or f5U)
[+]

This study shows for the first time that carnosic acid and trastuzumab cooperate in inhibiting breast cancer cell migration and survival.Nov 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2017 Nov 3 ;36(1):154. Epub 2017 Nov 3. PMID: 29100552
Article Published Date : Nov 02, 2017
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer
Pharmacological Actions : Cell cycle arrest, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Thymoquinone can enhance the anticancer activity of bortezomib in vitro and in vivoFeb 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2014 Feb 15 ;5(3):634-48. PMID: 24504138
Article Published Date : Feb 14, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Thymoquinone increased the potency of valproate in both PTZ and MES models.Dec 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Health Sci (Qassim). 2008 Jan ;2(1):15-25. PMID: 21475467
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy
[+]

Tinospora cordifolia extract could increase in the bio availability of glibenclamide.Mar 19, 2018

Pubmed Data : J Pharm Biomed Anal. 2018 Mar 20 ;151:310-316. Epub 2018 Jan 10. PMID: 29413979
Article Published Date : Mar 19, 2018
Study Type : Animal Study
Additional Links
Substances : Guduchi
Additional Keywords : Increased Bioavailability, Medication Reduction, Natural Substance/Drug Synergy, Plant Extracts
Problem Substances : Glibenclamide
[+]

Valerenic acid and valerian extracts have anticonvulsant properties in adult zebrafish. Jul 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 Jul 14 ;15:228. Epub 2015 Jul 14. PMID: 26168917
Article Published Date : Jul 13, 2015
Study Type : Animal Study
Additional Links
Substances : Valerian
Diseases : Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations.Mar 29, 2017

Pubmed Data : Mol Carcinog. 2017 Mar 30. Epub 2017 Mar 30. PMID: 28370562
Article Published Date : Mar 29, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Malignant Melanoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain.Jul 14, 2016

Pubmed Data : Life Sci. 2016 Jul 15 ;157:25-31. Epub 2016 May 28. PMID: 27245275
Article Published Date : Jul 14, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Neuropathic Pain, Oxidative Stress
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
[+]

WIN55212 and morphine reduced allodynia in a synergistic manner.Jun 08, 2016

Pubmed Data : Br J Pharmacol. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27278681
Article Published Date : Jun 08, 2016
Study Type : Animal Study
Additional Links
Substances : Cannabinoids: Synthetic
Diseases : Allodynia, Neuropathic Pain
Additional Keywords : Natural Substance/Drug Synergy
[+]

Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs.Jan 14, 2017

Pubmed Data : Phytomedicine. 2017 Jan 15 ;24:87-95. Epub 2016 Nov 16. PMID: 28160866
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Interleukin-10 downregulation, Interleukin-12 upregulation, Interleukin-4 downregulation, Leishmanicidal, Nitric Oxide Enhancer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Wogonin and 5-fluorouracil combination treatment caused a significant growth inhibition of human tumor xenografts in vivo.Jul 31, 2013

Pubmed Data : Biochem Cell Biol. 2013 Aug ;91(4):221-9. Epub 2013 Feb 14. PMID: 23859016
Article Published Date : Jul 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Drug: 5-flourouracil, Natural Substance/Drug Synergy, Plant Extracts
[+]

Wogonin combined with low-dose paclitaxel obtained the same efficacy as with high dose Paclitaxel reducing tumor burden by 61%.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin J Cancer Res. 2013 Oct ;25(5):505-13. PMID: 24255573
Article Published Date : Sep 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Natural Substance/Drug Synergy
[+]

Wogonin represses multiple myeloma stimulated angiogenesis and tumor progression.Dec 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Dec 30. Epub 2015 Dec 30. PMID: 26735336
Article Published Date : Dec 29, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Multiple Myeloma
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

γ-tocotrienol potentiates and sustains the 5-FU-induced expression of Nrf2 in human keratinocytes, leading to the continuous degradation of 5-FU-generated ROSMar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2015 Apr ;46(4):1453-60. Epub 2015 Jan 26. PMID: 25625649
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Pharmacological Actions : Chemoprotective Agents, Nrf2 activation, Radioprotective
Additional Keywords : Natural Substance/Drug Synergy
[+]

"Antibacterial and synergy of berberines with antibacterial agents against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA)."Dec 31, 2011

Pubmed Data : Molecules. 2012 ;17(9):10322-30. Epub 2012 Aug 29. PMID: 22932213
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

"Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation."May 31, 2012

Pubmed Data : Expert Opin Investig Drugs. 2012 Jun ;21(6):819-31. Epub 2012 Apr 16. PMID: 22500582
Article Published Date : May 31, 2012
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity, Oxidative Stress, Radiation Induced Illness
Pharmacological Actions : Antineoplastic Agents, Antioxidants
Additional Keywords : Natural Substance/Drug Synergy
[+]

A combination of pemetrexed and astaxanthin resulted in synergistic enhancing cytotoxicity and cell growth inhibition in NSCLC cells.Sep 27, 2016

Pubmed Data : Regul Toxicol Pharmacol. 2016 Sep 28. Epub 2016 Aug 28. PMID: 27693704
Article Published Date : Sep 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

A maple syrup extract exhibited antimicrobial activity as well as strong synergistic interaction with selected antibiotics against gram negative clinical strains of bacteria.Mar 26, 2015

Pubmed Data : Appl Environ Microbiol. 2015 Mar 27. Epub 2015 Mar 27. PMID: 25819960
Article Published Date : Mar 26, 2015
Study Type : In Vitro Study
Additional Links
Substances : Maple Syrup
Diseases : Bacterial Infections: Resistance/Biofilm Formation, Escherichia coli Infections, Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antimicrob Agents Chemother. 2019 Feb ;63(2). Epub 2019 Jan 29. PMID: 30420480
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Breast Milk
Diseases : Mycobacterium tuberculosis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

A review of cannabis and cannabinoids and their benefits in many health conditions. May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Pharmacol Ther. 2015 Jun ;97(6):575-86. Epub 2015 Apr 17. PMID: 25777363
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : AIDS, Cachexia: Cancer, Cancer: Pain , Cancers: All, Peripheral Neuropathies
Pharmacological Actions : Analgesics, Antiproliferative , Apoptotic, Appetite Stimulants, Chemopreventive
Additional Keywords : Natural Substance/Drug Synergy
[+]

A review of fucoidan which induces cell death within tumor cells and increases the survival rate of tumor-bearing animal models by suppression of metastasis and angiogenesis.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2015 Apr ;13(4):2327-46. Epub 2015 Apr 14. PMID: 25874926
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Fucoidan, Seaweed: Brown
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Anticarcinogenic Agents, Apoptotic, Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
[+]

A review of green tea catechins and their uses in treating infectious diseases. Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2018 ;2018:9105261. Epub 2018 Jul 17. PMID: 30105263
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate), Epicatechin
Diseases : Escherichia coli Infections, Helicobacter Pylori Infection, Pseudomonas aeruginosa, Staphylococcus aureus infection, Steptococcus Mutans Infections
Pharmacological Actions : Antimicrobial, Quorum Sensing Inhibition
Additional Keywords : Natural Substance/Drug Synergy
[+]

A review of the anticancer effects of ginsenoside Rg3. Feb 28, 2017

Pubmed Data : Int J Mol Med. 2017 Mar ;39(3):507-518. Epub 2017 Jan 13. PMID: 28098857
Article Published Date : Feb 28, 2017
Study Type : Review
Additional Links
Substances : Ginsenosides
Diseases : Cancers: All
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

A review of the clinical potential of pterostilbene in the prevention and treatment of various medical conditions.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2013 ;2013:575482. Epub 2013 Apr 4. PMID: 23691264
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Substances : Blueberry, Pterostilbene
Diseases : Breast Cancer, Cardiovascular Disease, Colon Cancer, Diabesity , Esophageal Cancer, Gastric Cancer, Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Cardioprotective, Neuroprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

A review of the combined effect of parthenolide and various anti-cancer drugs.Dec 31, 2013

Pubmed Data : Mini Rev Med Chem. 2014 ;14(3):222-8. PMID: 24552263
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Parthenolide
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Aloe-emodin significantly reduced the proliferation, stemness and invasive potential of melanospheres.Jun 02, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jun 3 ;762:283-292. Epub 2015 Jun 3. PMID: 26048310
Article Published Date : Jun 02, 2015
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic, Immunomodulatory
Additional Keywords : Natural Substance/Drug Synergy
[+]

Anti-parasitic activities of Allium sativum and Allium cepa against Trypanosoma b. brucei and Leishmania tarentolae.Apr 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicines (Basel). 2018 Apr 21 ;5(2). Epub 2018 Apr 21. PMID: 29690511
Article Published Date : Apr 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Onion
Diseases : Leishmaniasis, Trypanosomiasis
Pharmacological Actions : Antiparasitic Agents, Leishmanicidal
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice.Sep 30, 2008

Pubmed Data : Cancer Biother Radiopharm. 2008 Oct ;23(5):647-53. PMID: 18999937
Article Published Date : Sep 30, 2008
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Breast Cancer
Pharmacological Actions : Anti-Angiogenic, Chemotherapeutic, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antifungal effects of phytocompounds on Candida species alone and in combination with fluconazole.Jan 31, 2017

Pubmed Data : Int J Antimicrob Agents. 2017 Feb ;49(2):125-136. Epub 2016 Dec 15. PMID: 28040409
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Substances : Honokiol, Magnolol, Shikonin
Diseases : Candida Infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antimicrobial and enhancement of the antibiotic activity by phenolic compounds.Sep 30, 2016

Pubmed Data : Microb Pathog. 2016 Oct ;99:56-61. Epub 2016 Aug 3. PMID: 27497894
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid, Gallic Acid, Pyrogallol
Diseases : Candida Infection , Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antibiotics (Basel). 2019 May 4 ;8(2). Epub 2019 May 4. PMID: 31060239
Article Published Date : May 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : Piperine, Piperlongumine
Diseases : Candida Albicans, Pseudomonas aeruginosa, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antioxidants have the potential to be clinically applied to prevent cardiac toxicity and hand foot syndrome.Dec 24, 2014

Pubmed Data : Integr Cancer Ther. 2014 Dec 25. Epub 2014 Dec 25. PMID: 25542609
Article Published Date : Dec 24, 2014
Study Type : In Vitro Study
Additional Links
Substances : Antrodia cinnamomea , Curcumin, Resveratrol
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Reactive Oxygen Species (ROS) attenuation, Superoxide Dismutase Up-regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Aqueous extracts of Hibiscus sabdariffa could be used alone, or in combination with antibiotics for the treatment of HP infection.Jan 04, 2016

Pubmed Data : Pharm Biol. 2016 Jan 5:1-5. Epub 2016 Jan 5. PMID: 26731378
Article Published Date : Jan 04, 2016
Study Type : In Vitro Study
Additional Links
Substances : Hibiscus sabdariffa
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Arctigenin results in autophagic cell death and decreased ER expression in ER-positive human breast cancer cells.Feb 08, 2018

Pubmed Data : Int J Oncol. 2018 Feb 9. Epub 2018 Feb 9. PMID: 29436614
Article Published Date : Feb 08, 2018
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Arctigenin, Breast Cancer, Chemotherapeutic, Natural Substance/Drug Synergy
[+]

Arctiin has great value in treating various tumors sheltering constitutively activated STAT3.Feb 28, 2019

Pubmed Data : Phytomedicine. 2019 Mar 1 ;55:282-292. Epub 2018 Aug 11. PMID: 30668440
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Multiple Myeloma
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, STAT3 Inhibitor
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Artesunate demonstrates in vitro synergism with several antiviral agents against human cytomegalovirus.Dec 31, 2015

Pubmed Data : Antivir Ther. 2016 ;21(6):535-539. Epub 2016 Feb 4. PMID: 26844400
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Cytomegalovirus Infections
Pharmacological Actions : Antiviral Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Artesunate enhances the cytotoxicity of 5-aminolevulinic acid-based sonodynamic therapy against mouse mammary tumor cells.Mar 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Mar 27 ;22(4). Epub 2017 Mar 27. PMID: 28346389
Article Published Date : Mar 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Breast Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Artesunate with bortezomib shows a significant synergistic effects on proliferation, apoptosis and autophagy of MV4-11 cell lines.Mar 13, 2019

Pubmed Data : Zhonghua Xue Ye Xue Za Zhi. 2019 Mar 14 ;40(3):204-208. PMID: 30929387
Article Published Date : Mar 13, 2019
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ascorbic acid along with antibiotics ofloxacin or chloramphenicol promoted bacterial clearance.Jan 31, 2018

Pubmed Data : Microb Pathog. 2018 Feb ;115:239-250. Epub 2017 Dec 20. PMID: 29274459
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Inflammation, Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ascorbic acid synergistically potentiates phloxine b-induced photocytotoxicity in human acute promyelocytic leukemia cells.Mar 31, 2014

Pubmed Data : J Biochem Mol Toxicol. 2014 Apr ;28(4):167-73. Epub 2014 Jan 31. PMID: 24488945
Article Published Date : Mar 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Oxidative Stress, Promyelocytic leukemia
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Astaxanthin and carbendazim co-treatment enhances the anti-proliferative effect of carbendazim as a single agent.Dec 12, 2018

Pubmed Data : In Vitro Cell Dev Biol Anim. 2018 Dec 13. Epub 2018 Dec 13. PMID: 30547284
Article Published Date : Dec 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Natural Substance/Drug Synergy
[+]

Astragaloside IV enhances taxol chemosensitivity of breast cancer.Aug 25, 2018

Pubmed Data : J Cell Physiol. 2018 Aug 26. Epub 2018 Aug 26. PMID: 30146689
Article Published Date : Aug 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug: Taxol, Natural Substance/Drug Synergy
[+]

Baicalein combinated with taxol at low concentrations could exert synergistic antitumor effects in ovarian cancer cells.Oct 31, 2016

Pubmed Data : DNA Cell Biol. 2016 Nov ;35(11):646-656. Epub 2016 Jul 14. PMID: 27414207
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Baicalein seems to be a promising novel effective synergistic antimicrobial agent.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Microbiol. 2016 ;16(1):181. Epub 2016 Aug 8. PMID: 27502110
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Klebsiella Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Bee venom has antibacterial and synergistic activities with ampicillin, penicillin, gentamicin and vancomycin against MRSA strains.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 ;21(1). Epub 2016 Jan 12. PMID: 26771592
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Bee Venom
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Antimicrobial
Additional Keywords : Gene Expression Regulation, Natural Substance/Drug Synergy
[+]

Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.Jul 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Jul 23. Epub 2019 Jul 23. PMID: 31338966
Article Published Date : Jul 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Breast Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Natural Substance/Drug Synergy
[+]

Berberine can inhibit MRSA biofilm formation and could enhance the bactericidal activity of antibiotics.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:24748. Epub 2016 Apr 22. PMID: 27103062
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Biofilm, Natural Substance/Drug Synergy
[+]

Berberine has a synergistic effect with imipenem to re-sensitize imipenem resistant P. aeruginosa.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Jan ;15(1):467-472. Epub 2017 Nov 1. PMID: 29387199
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Bergamot juice was effective against H. pylori strains in vitro, both alone and in combination with antibiotics.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15:256. Epub 2015 Jul 30. PMID: 26220068
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bergamot orange
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Antibiotics
[+]

Beta-elemene potentiates the cytotoxic effects of various antineoplastic drugs in cell lines overexpressing the ABCB1 transporter.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2014 Feb ;31(2):858-66. Epub 2013 Nov 27. PMID: 24284783
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Beta-sesquiphellandrenehas anticancer potential that was comparable to that of curcumin.Nov 30, 2015

Pubmed Data : Invest New Drugs. 2015 Dec ;33(6):1175-86. Epub 2015 Nov 2. PMID: 26521943
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Beta-sesquiphellandrene, Turmeric
Diseases : Colorectal Cancer, Leukemia, Lung Cancer, Multiple Myeloma
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Bcl-xL down-regulation, Survivin Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Black tea extract and theaflavins exerts antibacterial activity against major periodontopathogens.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0143158. Epub 2015 Nov 18. PMID: 26581041
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Periodontal Diseases
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-8 downregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

C. verum and P. graveolens could be effective candidates to enhance the efficacy of fluconazole-based therapy of C. albicans infections.Aug 31, 2017

Pubmed Data : Appl Microbiol Biotechnol. 2017 Sep ;101(18):6993-7006. Epub 2017 Aug 1. PMID: 28766033
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon, Pelargonium graveolens
Diseases : Candida Infection
Pharmacological Actions : Antifungal Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cabazitaxel and thymoquinone co-loaded lipospheres are the efficient delivery vehicles in management of breast cancer.Dec 02, 2018

Pubmed Data : Chem Phys Lipids. 2018 Dec 3. Epub 2018 Dec 3. PMID: 30521787
Article Published Date : Dec 02, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

cafestol may be effectively used to enhance ABT-737 sensitivity in cancer therapy via downregulation of Mcl-1 expression and upregulation of Bim expression. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2014 ;5:e1514. Epub 2014 Nov 6. PMID: 25375379
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cafestol
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy, Selective Cytotoxicity
[+]

Caffeic acid expands anti-tumor effect of Metformin in human metastatic cervical carcinoma HTB-34 cells.Feb 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Feb 21 ;18(2). Epub 2017 Feb 21. PMID: 28230778
Article Published Date : Feb 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid
Diseases : Cervical Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Caffeic acid phenethyl ester synergistically enhances the antifungal activity of fluconazole against resistant Candida albicans.Jan 31, 2018

Pubmed Data : Phytomedicine. 2018 Feb 1 ;40:55-58. Epub 2018 Jan 2. PMID: 29496175
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Candida Albicans, Infection: Antibiotic Resistant
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Anti-Bacterial Agents, Caffeic acid phenethyl ester, Natural Substance/Drug Synergy
[+]

Calcitriol sensitizes prostate cancer cells to aPPD-mediated anticancer effects.Mar 31, 2016

Pubmed Data : J Steroid Biochem Mol Biol. 2016 Apr ;158:207-19. Epub 2015 Dec 17. PMID: 26709138
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides, Vitamin D
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cannabidiol by itself or in synergy with bortezomib strongly inhibited growth, arrested cell cycle progression and induced multiple myeloma cell death.May 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Cancer. 2014 Jun 1 ;134(11):2534-46. Epub 2013 Dec 2. PMID: 24293211
Article Published Date : May 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Multiple Myeloma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cannabidiol Is a novel modulator of bacterial membrane vesicles.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Infect Microbiol. 2019 ;9:324. Epub 2019 Sep 10. PMID: 31552202
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Escherichia coli Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration.Oct 17, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Oct 18. Epub 2016 Aug 18. PMID: 27769052
Article Published Date : Oct 17, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)
Diseases : Multiple Myeloma
Pharmacological Actions : Chemosensitizer
Additional Keywords : Dose Response, Natural Substance/Drug Synergy
[+]

Carnosic acid enhances the cytotoxicity of β-lapachone in melanoma cell lines.Jan 31, 2018

Pubmed Data : Oncol Lett. 2018 Feb ;15(2):2393-2400. Epub 2017 Dec 14. PMID: 29434949
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Melanoma
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Carnosic acid impedes cell growth and enhances anti-cancer effects of carmustine and lomustine in melanoma.May 21, 2018

Pubmed Data : Biosci Rep. 2018 May 22. Epub 2018 May 22. PMID: 29789400
Article Published Date : May 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Carnosol controls the human glioblastoma stemness features.Nov 08, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Nov 9 ;7(1):15174. Epub 2017 Nov 9. PMID: 29123181
Article Published Date : Nov 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosol
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic, Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Carvacrol shows good anti-M. tuberculosis activity and synergism with rifampicin.Dec 31, 2017

Pubmed Data : Future Microbiol. 2018 06 1 ;13:877-888. Epub 2018 Jun 7. PMID: 29877104
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol
Diseases : Mycobacterium tuberculosis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Celery Seed Extract has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis.Dec 31, 2014

Pubmed Data : Prog Drug Res. 2015 ;70:133-53. PMID: 26462366
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Celery seed
Diseases : Arthritis, Campylobacter Infections, Escherichia coli Infections, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antimicrobial, Gastroprotective
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Cell proliferation, viability and apoptosis of MDA-MB-231 cells were impaired by the combination of EGCG and tapentadol. Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2019 Sep-Oct;33(5):1463-1468. PMID: 31471393
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Chlorogenic acid improves the regorafenib effects in human hepatocellular carcinoma cells.May 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 May 19 ;19(5). Epub 2018 May 19. PMID: 29783729
Article Published Date : May 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
[+]

Chokeberry extract in combination with gemcitabine was more effective than gemcitabine alone.Sep 16, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Pathol. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25232128
Article Published Date : Sep 16, 2014
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Chokeberry
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Natural Substance/Drug Synergy
[+]

Cinnamon bark oil and cinnamaldehyde might be an alternative treatment for multidrug-resistant P. aeruginosa infection.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Jun 1 ;16:158. Epub 2016 Jun 1. PMID: 27245046
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde, Cinnamon
Diseases : Infection: Antibiotic Resistant, Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy, Plant Oils
[+]

Co-administration of cytotoxic agents together with CBD increases drug uptake and potentiates cytotoxic activity in human glioma cells.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2013 Jan ;34(1):48-57. Epub 2012 Oct 18. PMID: 23079154
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Co-administration with nilotinib and perilla-derived methoxyflavanone significantly suppressed in vivo tumorigenicity of A549 cells in mice.Jul 28, 2017

Pubmed Data : Cytotechnology. 2017 Jul 29. Epub 2017 Jul 29. PMID: 28756527
Article Published Date : Jul 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Perilla
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
[+]

Co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0139298. Epub 2015 Sep 30. PMID: 26421434
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Colon Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Dose Response, Natural Substance/Drug Synergy
[+]

Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells.Jun 30, 2013

Pubmed Data : Anticancer Drugs. 2013 Jul ;24(6):577-86. PMID: 23542749
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2017 Nov ;108(11):2265-2272. Epub 2017 Sep 19. PMID: 28846180
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Antiproliferative, Apoptotic, Betulinic acid, Carcinoma: Non-Small-Cell Lung, Natural Substance/Drug Synergy
[+]

Combination therapy with sulindac and vitamin C could be a novel anti-cancer therapeutic strategy for p53 wild type colon cancers.Jun 19, 2016

Pubmed Data : Toxicol Lett. 2016 Jun 20. Epub 2016 Jun 20. PMID: 27339904
Article Published Date : Jun 19, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combination treatment with cyclophosphane and its homeopathically potentiated forms increases antiblastic activity of the preparation.Dec 31, 2002

Pubmed Data : Bull Exp Biol Med. 2003 Jan ;135 Suppl 7:107-10. PMID: 12949669
Article Published Date : Dec 31, 2002
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Lung Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combination treatment with parthenolide and balsalazide may offer an effective strategy for the induction of apoptosis in HCT116 cells.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Intest Res. 2015 Jul ;13(3):233-41. Epub 2015 Jun 9. PMID: 26130998
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combined treatment induced apoptosis more efficiently than either agent alone; however the most effective was a combination of lapatinib with erucin.Jul 01, 2015

Pubmed Data : Nutr Cancer. 2015 Jul 2:1-11. Epub 2015 Jul 2. PMID: 26134366
Article Published Date : Jul 01, 2015
Study Type : In Vitro Study
Additional Links
Substances : Erucin, Sulforaphane
Diseases : Breast Cancer: HER-2 Overexpressed
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Drug: Allopurinol, Isothiocyanates, Natural Substance/Drug Synergy
[+]

Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells.Dec 15, 2019

Pubmed Data : J Cancer Res Clin Oncol. 2019 Dec 16. Epub 2019 Dec 16. PMID: 31844979
Article Published Date : Dec 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Demethoxycurcumin
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combined use of doxycycline and vitamin C could represents a new synthetic-lethal metabolic strategy for eradicating CSCs.Sep 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Sep 15 ;8(40):67269-67286. Epub 2017 Jun 9. PMID: 28978032
Article Published Date : Sep 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Combined use of lower concentrations of jerantinine A and γ-tocotrienol induced potent cytotoxic effects on U87MG cancer cells.Jun 30, 2017

Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:74-84. Epub 2017 Mar 10. PMID: 28545672
Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemoprotective Agents, Chemosensitizer, Chemotherapeutic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Antiproliferative, Apoptotic, Cell cycle arrest, Glioblastoma, Natural Substance/Drug Synergy, Vitamin E: Gamma-tocotrienol
[+]

Combining high-dose vitamin C with conventional anti-cancer drugs can have therapeutic advantages against breast cancer cells.Jan 31, 2019

Pubmed Data : Anticancer Res. 2019 Feb ;39(2):751-758. PMID: 30711954
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Combining the Quercetin with rituximab may present an attractive and potentially effective way for the treatment of DLBCL. Oct 31, 2014

Pubmed Data : Cell Biochem Biophys. 2014 Nov ;70(2):1357-62. PMID: 24902540
Article Published Date : Oct 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Non-Hodgkin's lymphoma: B Cell
Pharmacological Actions : STAT3 Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cucurbitacin B alone or in combination with methotrexate shows promising antiproliferative activity against human osteosarcoma.Jul 27, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Lett. 2011 Jul 28 ;306(2):161-70. Epub 2011 Mar 26. PMID: 21440986
Article Published Date : Jul 27, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin ameliorates the targeted delivery of methotrexate intercalated montmorillonite clay to cancer cells.Jun 30, 2019

Pubmed Data : Eur J Pharm Sci. 2019 Jul 1 ;135:91-102. Epub 2019 May 9. PMID: 31078644
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on drug-resistant carcinosarcoma cells.Jul 07, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Biochim Pol. 2016 Jul 8. Epub 2016 Jul 8. PMID: 27390785
Article Published Date : Jul 07, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: Drug Resistant, Carcinosarcomas
Pharmacological Actions : Anti-metastatic, Chemoprotective Agents, Cytotoxic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin can be used as a modulator which may have a potential therapeutic value for the treatment of retinoblastoma cancer patients.Dec 10, 2014

Pubmed Data : Curr Eye Res. 2014 Dec 11:1-13. Epub 2014 Dec 11. PMID: 25495096
Article Published Date : Dec 10, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Retinoblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin could enhance the effects of irinotecan on colorectal cancer cells.Apr 03, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Apr 4. Epub 2017 Apr 4. PMID: 28402965
Article Published Date : Apr 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin could increase the sensitivity of leukemia stem-like KG1a cells to busulfan by downregulating the expression of survivin.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015;2015:630397. Epub 2015 Oct 18. PMID: 26557682
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Chemosensitizer, Survivin Down-Regulation
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Curcumin could provide a novel strategy to combat antibiotic resistance and virulence of M. abscessus.Nov 28, 2017

Pubmed Data : Phytother Res. 2017 Nov 29. Epub 2017 Nov 29. PMID: 29193368
Article Published Date : Nov 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Infection: Antibiotic Resistant, Mycobacterium abscessus
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin had a high synergistic interaction with the antibiotics Amikacin, Gentamicin and Ciprofloxacin.Oct 31, 2015

Pubmed Data : Pak J Pharm Sci. 2015 Nov ;28(6):2109-14. PMID: 26639480
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Antibiotics
[+]

Curcumin has antibacterial synergy with antibiotics against biofilm producing clinical bacterial isolates.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Basic Clin Pharm. 2016 Jun ;7(3):93-6. PMID: 27330262
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Biofilm, Natural Substance/Drug Synergy
[+]

Curcumin has potential as a chemosensitizer for carboplatin in the treatment of patients with NSCLC.Feb 24, 2015

Pubmed Data : Exp Biol Med (Maywood). 2015 Feb 25. Epub 2015 Feb 25. PMID: 25716014
Article Published Date : Feb 24, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemosensitizer, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Drug: Carboplatin, Natural Substance/Drug Synergy
[+]

Curcumin has the potential to improve the effect of chemotherapeutic agents against acute lymphoblastic leukemia.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Nov ;12(5):4117-4124. Epub 2016 Sep 30. PMID: 27895780
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Chemosensitizer, Chemotherapeutic, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin in combination with antibiotics could lead to the development of new combination of antibiotics against MRSA infection.Jun 14, 2013

Pubmed Data : Phytomedicine. 2013 Jun 15 ;20(8-9):714-8. Epub 2013 Mar 26. PMID: 23537748
Article Published Date : Jun 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Turmeric
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.Jul 31, 2017

Pubmed Data : Clin Sci (Lond). 2017 Aug 1 ;131(15):1781-1799. Epub 2017 Jul 5. PMID: 28679846
Article Published Date : Jul 31, 2017
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Chemosensitizer, Chemotherapeutic, Radiosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumin potentiates the fungicidal effect of dodecanol.Sep 30, 2018

Pubmed Data : Lett Appl Microbiol. 2018 Oct 1. Epub 2018 Oct 1. PMID: 30276838
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumins ability to augment the apoptotic effects of ceramides, suggest it would have a synergistic effect with cytotoxic chemotherapy agents.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2015 Dec ;35(12):6373-8. PMID: 26637846
Article Published Date : Nov 30, 2015
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Glioblastoma
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer.Dec 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Dec 29 ;8(70):115526-115545. Epub 2017 Dec 14. PMID: 29383179
Article Published Date : Dec 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcurmin potentiates the cytotoxic effects of tamoxifen on K562 cells and also decreases the associated cytotoxicity on red blood cells and polymorphonuclear leukocytes.Jul 31, 2013

Pubmed Data : J Enzyme Inhib Med Chem. 2013 Aug ;28(4):734-40. Epub 2012 Apr 23. PMID: 22524678
Article Published Date : Jul 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Vanillin
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Doxycycline and vitamin C may represent a new synthetic lethal drug combination for eradicating cancer stem cells.Jun 08, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Jun 9. Epub 2017 Jun 9. PMID: 28622697
Article Published Date : Jun 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Berberine, Vitamin C
Diseases : Breast Cancer, Breast Cancer Stem Cells, Cancers: All
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells.Sep 30, 2017

Pubmed Data : Pathol Res Pract. 2017 Oct ;213(10):1242-1250. Epub 2017 Sep 12. PMID: 28964574
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cancers: Multi-Drug Resistant, Esophageal Cancer
Pharmacological Actions : Chemotherapeutic, Multidrug Resistance Gene Modulators
Additional Keywords : Natural Substance/Drug Synergy
[+]

EGCG-antibiotic combinations might provide an alternative approach to treat infections with A. baumannii regardless of antibiotic resistance.Jan 14, 2017

Pubmed Data : Phytomedicine. 2017 Jan 15 ;24:49-55. Epub 2016 Nov 17. PMID: 28160861
Article Published Date : Jan 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Acinetobacter baumannii infection, Infection: Antibiotic Resistant
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Emodin reduces the activity of (1,3)-β-D-glucan synthase from Candida albicans and does not interact with caspofungin.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pol J Microbiol. 2018 ;67(4):463-470. PMID: 30550232
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Candida Albicans
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Enhanced cytotoxic activity of cetuximab in EGFR-positive lung cancer by conjugating with gold nanoparticles.Dec 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2014 Dec 15 ;4:7490. Epub 2014 Dec 15. PMID: 25502402
Article Published Date : Dec 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Gold (nanoparticles)
Diseases : Lung Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ferulic acid also demonstrated a synergistic effect in combination with caspofungin against C. albicans.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2018 Jan ;26(1):439-443. Epub 2017 Feb 13. PMID: 29389586
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Candida Albicans
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ferulic acid potentiates the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii.Dec 31, 2018

Pubmed Data : Microb Pathog. 2019 Jan ;126:393-398. Epub 2018 Nov 23. PMID: 30476577
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Acinetobacter baumannii infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Folic acid receptor-targeted solid lipid nanoparticles to enhance cytotoxicity of letrozole.Jan 01, 2020

Pubmed Data : Pharm Dev Technol. 2020 Jan 2:1-11. Epub 2020 Jan 2. PMID: 31893979
Article Published Date : Jan 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Folic Acid
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Formononetin and epirubicin may pave the way for a powerful chemotherapeutic regimen for treating human cervical cancer.Oct 04, 2013

Pubmed Data : Chem Biol Interact. 2013 Oct 5 ;205(3):188-97. Epub 2013 Jul 16. PMID: 23867903
Article Published Date : Oct 04, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:2084-2089. Epub 2018 Nov 26. PMID: 30551465
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Hypoglycemic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Fucoidan has been shown to synergize with standard anti-cancer agents and reduces their side effects.Mar 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 14 ;8(11):17887-17896. PMID: 28060735
Article Published Date : Mar 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Melanoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

G1-4A may offer an attractive option of adjunct therapy for tuberculosis treatment along with current anti-TB drugs.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0154725. Epub 2016 Aug 5. PMID: 27148868
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Guduchi
Diseases : Mycobacterium tuberculosis
Pharmacological Actions : Immunomodulatory, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance/Drug Synergy, Polysaccharides
[+]

Galbanic acid enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus.Aug 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2007 Sep ;30(9):1805-7. PMID: 17827745
Article Published Date : Aug 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Galbanic Acid
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Gamma tocotrienol inhibited the growth of human colorectal cancer cells and sensitised them to capecitabine.Aug 29, 2016

Pubmed Data : Br J Cancer. 2016 Aug 30. Epub 2016 Aug 30. PMID: 27575851
Article Published Date : Aug 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Grape seed extract attenuates hepatitis C virus replication and virus-induced inflammation.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:490. Epub 2016 Dec 21. PMID: 28066241
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Hepatitis C
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

Green tea is a cancer preventive, and green tea catechins act as synergists with anticancer compounds. Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Prev. 2015 Mar ;20(1):1-4. PMID: 25853098
Article Published Date : Feb 28, 2015
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
Additional Keywords : Natural Substance/Drug Synergy, Natural Substance Synergy, Plant Extracts, Recurrence Risk, Risk Reduction
[+]

Hatay propolis samples have important antiviral effects compared with acyclovir.Feb 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2016 Feb 9 ;22:422-30. Epub 2016 Feb 9. PMID: 26856414
Article Published Date : Feb 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bee Propolis
Diseases : Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2
Pharmacological Actions : Antiviral Agents
Additional Keywords : Natural Substance/Drug Synergy, Superiority of Natural Substances versus Drugs
[+]

Hesperidin and silibinin showed potential anti-leukemic activity hence may be used for AML therapy alone or in combination with other chemotherapeutic agents.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Res Ther. 2015 Apr-Jun;11(2):352-7. PMID: 26148599
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin, Silibinin
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Dose Response, Drug: Cytarabine, Natural Substance/Drug Synergy
[+]

Honey has potential as an adjunct treatment with rifampicin for chronic wounds infected with staphylococcal biofilms.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2017 ;8:2653. Epub 2018 Jan 11. PMID: 29375518
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Manuka Honey
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Anti-Bacterial Agents, Biofilm, Manuka Honey, Natural Substance/Drug Synergy, Staphylococcus aureus infection
[+]

Honokiol targets mitochondria to halt cancer progression and metastasis.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2016 Jun ;60(6):1383-95. Epub 2016 May 6. PMID: 27276215
Article Published Date : May 31, 2016
Study Type : Review
Additional Links
Substances : Honokiol
Diseases : Bone Cancer, Breast Cancer, Gastric Cancer, Glioblastoma, Kidney Cancer, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer, Radiosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine, Chemotherapeutic Synergy: Oxaliplatin, Natural Substance/Drug Synergy
[+]

Immunomodulatory and antimicrobial effects of vitamin C.Oct 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Microbiol Immunol (Bp). 2019 Oct 3 ;9(3):73-79. Epub 2019 Aug 16. PMID: 31662885
Article Published Date : Oct 02, 2019
Study Type : Review
Additional Links
Substances : Pomegranate, Quercetin, Vitamin C, White Tea
Diseases : Campylobacter Infections, Helicobacter Pylori Infection, Klebsiella Infections, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Staphylococcus aureus infection, Staphylococcus epidermidis
Pharmacological Actions : Antimicrobial, Immunomodulatory
Additional Keywords : Natural Substance/Drug Synergy, Natural Substance Synergy
[+]

In animal experiments, wheatgrass demonstrated benefits in cancer prevention and as an adjunct to cancer treatment.Dec 31, 2014

Pubmed Data : Mini Rev Med Chem. 2015 ;15(12):1002-10. PMID: 26156538
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Wheat Grass
Diseases : Cancers: All, Oxidative Stress, Rheumatoid Arthritis, Ulcerative Colitis
Pharmacological Actions : Antioxidants, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

In this review, they have summarized the recent progress on dietary nutraceuticals in reversing multidrug resistance.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(16):6831-9. PMID: 26514453
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : beta-Carotene, Bitter Melon, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Fruit: All, Fucoxanthin , Gingerol , Grape Seed Extract, Indole-3-Carbinol, Piperine, Quercetin, Resveratrol, Vegetables: All
Diseases : Cancers: All
Pharmacological Actions : Multidrug Resistance Gene Modulators
Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy
[+]

Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment.Jan 16, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Cancer. 2012 Jan 17 ;106(2):333-43. Epub 2011 Dec 13. PMID: 22166800
Article Published Date : Jan 16, 2012
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
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Indole-3-carbinol synergizes with and restores fludarabine sensitivity in chronic lymphocytic leukemia cells .Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2016 Jan 1 ;22(1):134-45. Epub 2015 Aug 31. PMID: 26324744
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Chronic Lymphocytic Leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Natural Substance/Drug Synergy
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Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation.Apr 09, 2018

Pubmed Data : Nucleosides Nucleotides Nucleic Acids. 2018 Apr 10:1-10. Epub 2018 Apr 10. PMID: 29634384
Article Published Date : Apr 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Epigenetic Modification In Cancer, Natural Substance/Drug Synergy, Reactivation Of Tumor Suppressor Gene
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Korean red ginseng extract can enhance the anticancer activity of imatinib mesylate and may have a substantial potential in the treatment of chronic myelogenous leukemia.Apr 07, 2015

Pubmed Data : Phytother Res. 2015 Apr 8. Epub 2015 Apr 8. PMID: 25857479
Article Published Date : Apr 07, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
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Liposome as a drug delivery system shows great advantages over traditional formulations for β-elemene.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:259523. Epub 2012 Nov 28. PMID: 23243436
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Substances : Beta-Elemene
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Low dose Resveratrol and Curcumin enhances the Centchroman action through ROS mediated JNK/p38 as well as mitochondrial pathway in MCF-7 cells.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(6):e37736. Epub 2012 Jun 29. PMID: 22768036
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Polyphenols, Resveratrol
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Natural Substance/Drug Synergy
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Luteolin and quercetin have a synergistic effect with ceftazidime against S. pyogenes and β-lactamase. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015;2015:759459. Epub 2015 Oct 21. PMID: 26576195
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lutein, Quercetin
Diseases : Streptococcus pyogenes
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Antibiotics
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Luteolin plays an important role in the treatment of human choriocarcinoma cells.Aug 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Reprod. 2016 Aug 31. Epub 2016 Aug 31. PMID: 27580988
Article Published Date : Aug 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Choriocarcinoma
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Natural Substance/Drug Synergy
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Luteolin, quercetin, and antibiotics have complemented each another against MRSA.Nov 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Nov 22 ;17(11). Epub 2016 Nov 22. PMID: 27879665
Article Published Date : Nov 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Luteolin, Quercetin
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy, Natural Substance Synergy
Problem Substances : Antibiotics
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Magnolol and honokiol are potentially useful for the treatment of drug-resistant S. aureus infections when used in combination with lower concentration of antibiotics.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:283630. Epub 2015 Aug 19. PMID: 26357651
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolia, Magnolol
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Antimicrobial
Additional Keywords : Dose Response, Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts
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Magnolol and honokiol showed a broad spectrum of synergistic potentiation of conventional antibacterial agents.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):425. Epub 2015 Dec 1. PMID: 26627468
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolol
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Antibiotic Resistance, Natural Substance/Drug Synergy, Natural Substances Versus Drugs, Resistance Reversal
Problem Substances : Antibiotics
[+]

Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs.May 31, 2016

Pubmed Data : Int J Oncol. 2016 Jun ;48(6):2704-12. Epub 2016 Apr 1. PMID: 27035859
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Multiple Myeloma
Pharmacological Actions : Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Mango ginger treatment inhibited tumor growth rate with and without VBL and increased the survival rate significantly.May 03, 2015

Pubmed Data : Phytother Res. 2015 May 4. Epub 2015 May 4. PMID: 25939344
Article Published Date : May 03, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginger, Turmeric
Diseases : Rhabdomyosarcoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords :