Natural Substance/Drug Synergy

Name	AC	CK
Fluoxetine (trade name Prozac)	2	20
Sertraline	2	20
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	2	11
Antidepressants	1	10
Mesalamine	1	10
Simvastatin	1	10
Statin Drugs	1	10
Doxorubicin	2	7
Antibiotics	4	4
Cisplatin	2	4
Fluorouracil (5-FU or f5U)	1	2
Nicotine	1	2
Paclitaxel	1	2
Prednisolone	1	2
Zoledronic Acid	1	2

Name	AC	CK
Depression	5	50
Breast Cancer	17	34
Colorectal Cancer	7	33
Helicobacter Pylori Infection	5	23
Depression: Postmenopausal	2	20
Cancers: All	13	18
Oxidative Stress	6	17
Cancers: Drug Resistant	8	15
Rheumatoid Arthritis	3	13
Chronic Pain	2	11
Ulcerative Colitis	2	11
Acute lymphoblastic leukemia (ALL)	1	10
Anxiety Disorders	1	10
Atherosclerosis	1	10
Breast Cancer: Metastatic	1	10
C-Reactive Protein	1	10
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	10
Cholesterol: High	1	10
Colorectal Adenomas	1	10
Depressive Disorder	1	10
Drug-Induced Toxicity: Methotrexate	1	10
High Cholesterol	1	10
Peripheral Arterial Disease	1	10
Triglycerides: Elevated	1	10
Colon Cancer	6	9
Lung Cancer	6	9
Multiple Myeloma	6	9
Breast Cancer: Triple Negative	5	7
Carcinoma: Non-Small-Cell Lung	4	7
Leukemia	7	7
Staphylococcus aureus: Methicillin-resistant (MRSA)	7	7
Gastric Cancer	4	6
Prostate Cancer	5	6
Arthritis	3	5
Breast Cancer Stem Cells	1	5
Breast Cancer: Drug Resistant	1	5
Ebola Virus Infections	1	5
Escherichia coli Infections	5	5
Pancreatic Cancer	4	5
Staphylococcus aureus infection	5	5
Allodynia	2	4
Lipid Peroxidation	2	4
Neuropathic Pain	2	4
Pseudomonas aeruginosa	4	4
Toxoplasma gondii Infection	2	4
Candida Albicans	2	3
Chemotherapy-Induced Toxicity	2	3
Esophageal Cancer	2	3
Inflammation	2	3
Liver Cancer	2	3
Melanoma	2	3
Acute Myeloid Leukemia	2	2
Candida Infection	2	2
Candidiasis	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Cryptococcosis	1	2
Fibrosarcoma	1	2
Glioblastoma	2	2
Glioma	2	2
Gram-Negative Bacterial Infections	2	2
Hyperalgesia	1	2
Inflammatory Bowel Diseases	1	2
Kidney Cancer	2	2
Liver Metastasis From Colon Cancer	1	2
Malignant Melanoma	1	2
Memory Loss	1	2
Sepsis	1	2
Skin Cancer	1	2
Toxoplasmosis	1	2
AIDS	1	1
Alzheimer's Disease	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cachexia: Cancer	1	1
Campylobacter Infections	1	1
Cancer Metastasis	1	1
Cancer: Pain	1	1
Cancers: Multi-Drug Resistant	1	1
Carcinosarcomas	1	1
Cardiovascular Disease	1	1
Cervical Cancer	1	1
Chemotherapy	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chemotherapy-Induced Toxicity: Tamoxifen	1	1
Chronic Lymphocytic Leukemia	1	1
Cystic Fibrosis	1	1
Diabesity	1	1
Epilepsy	1	1
Epileptic Seizures	1	1
Fungal Infections: Biofilm Formation/Resistance	1	1
Glioblastoma Multiforme	1	1
Gram-Positive Bacterial Infections	1	1
Headache	1	1
Klebsiella Infections	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Melanoma: Metastatic	1	1
Mycobacterium tuberculosis	1	1
Neurofibromatosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Oral Cancer	1	1
Osteosarcoma	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Peripheral Neuropathies	1	1
Radiation Induced Illness	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Schwannoma	1	1
Squamous cell carcinoma	1	1
Streptococcus pyogenes	1	1

Name	AC	CK
Curcumin	26	59
Chinese Skullcap	2	21
Astragalus	1	20
Hedyotis corymbosa	1	20
Soy	2	20
EGCG (Epigallocatechin gallate)	7	13
Silibinin	4	13
Vitamin D	3	13
Cannabis	3	12
Melatonin	3	12
Nigella sativa (aka Black Seed)	2	12
Fucoidan	2	11
Pomegranate	2	11
Quercetin	10	11
Flaxseed	1	10
Lactobacillus reuteri	1	10
Lavender	1	10
Piperidines	1	10
Probiotics	1	10
Green Tea	4	9
Vitamin C	5	8
Catechin	3	7
Gingerol	3	7
Wogonin	4	7
Pterostilbene	2	6
6-Shogaol	1	5
Amurensin G	1	5
Cannabidiol	4	5
Plantago major	1	5
Prunella vulgaris.	1	5
Resveratrol	4	5
Berberine	4	4
Cannabinoids	4	4
Cannabinoids: Synthetic	2	4
Polyphenols	4	4
Sulforaphane	3	4
Turmeric	4	4
Anthocyanins	2	3
Honokiol	3	3
Olive leaf extract	2	3
Thymoquinone	2	3
Allspice	1	2
Banana	1	2
Beta-glucan	1	2
Black Tea	2	2
Capsaicin	2	2
Chrysin	1	2
Cyanidin 3-glucoside	1	2
Devils Claw	1	2
Emodin	2	2
Evening Primrose Oil	1	2
Garlic: Aged	1	2
Ginger	2	2
Luteolin	1	2
Magnolol	2	2
Maitake Mushroom	1	2
Mangiferin	2	2
Nobiletin	1	2
Piperine	2	2
Puerarin	1	2
Resistant Starch	1	2
Vitamin E: alpha tocopherol	1	2
Allicin	1	1
Aloe Vera	1	1
Antrodia cinnamomea	1	1
Asparagus	1	1
Baicalein	1	1
Basil	1	1
Beans: All	1	1
Bee Venom	1	1
Beet	1	1
Bergamot orange	1	1
Bitter Melon	1	1
Black Currant	1	1
Blueberry	1	1
Cafestol	1	1
Cayenne	1	1
Celery seed	1	1
Chokeberry	1	1
Citrus naringin	1	1
Cruciferous Vegetables	1	1
Cucurbitacin B	1	1
Echinacea	1	1
Erucin	1	1
Fruit: All	1	1
Fucoxanthin	1	1
Genistein	1	1
Ginseng (Korean)	1	1
Ginsenosides	1	1
Glycyrrhizin	1	1
Grape	1	1
Grape Seed Extract	1	1
Hesperidin	1	1
Hibiscus sabdariffa	1	1
Indole-3-Carbinol	1	1
Isothiocyanates	1	1
Lutein	1	1
Magnolia	1	1
Manuka Honey	1	1
Maple Syrup	1	1
Modified Arabinoxylan Rice Bran (MGN-3)	1	1
Plum	1	1
Rice Bran	1	1
Seaweed: Brown	1	1
Silver (nanoparticles)	1	1
Silymarin	1	1
Tangeretin	1	1
Theaflavins	1	1
Tocotrienols	1	1
Tomato	1	1
Vanillin	1	1
Vegetables: All	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin K	1	1
Watercress	1	1
Wheat Grass	1	1
Zinc	1	1
beta-Carotene	1	1

Name	AC	CK	Focus
Integrative Medicine	2	3

Name	AC	CK
Apoptotic	48	71
Antiproliferative	47	69
Antidepressive Agents	5	50
Chemosensitizer	22	44
Anti-Inflammatory Agents	13	35
Antioxidants	15	31
Chemotherapeutic	14	27
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	24
Antineoplastic Agents	13	19
Anti-Bacterial Agents	16	16
Analgesics	5	15
Chemopreventive	9	15
Anti-metastatic	11	13
Cell cycle arrest	10	12
Hepatoprotective	2	12
Interleukin-1 beta downregulation	2	12
Interleukin-8 downregulation	2	11
Anti-atherogenic	1	10
Anticholesteremic Agents	1	10
Hypolipidemic	1	10
Interleukin-6 Downregulation	1	10
Antimicrobial	9	9
Chemoprotective Agents	7	9
NF-kappaB Inhibitor	7	8
Anti-Tumor	2	7
Anti-Angiogenic	4	6
Angiogenesis Inhibitors	4	5
Anti-Retroviral Agents	1	5
Cyclin D1 Down-Regulation	1	5
Immunomodulatory	4	5
Cyclooxygenase 2 Inhibitors	3	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Anticarcinogenic Agents	3	3
Antifungal Agents	2	3
Bcl-2 protein down-regulation	3	3
Cardioprotective	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	3
MicroRNA modulator	2	3
Neuroprotective Agents	3	3
Vascular Endothelial Growth Factor Inhibitors	2	3
AKT-mammalian target of rapamycin (mTOR) pathway inhibitor	1	2
Antinoceceptive	1	2
Autophagy Up-regulation	1	2
Cyclooxygenase Inhibitors	1	2
Gastrointestinal Agents	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Interleukin-12 upregulation	1	2
Malondialdehyde Down-regulation	1	2
Radioprotective	2	2
Renoprotective	1	2
Survivin Down-Regulation	2	2
Tumor Suppressor Protein p53 Upregulation	2	2
apoptosis	1	2
Anti-Apoptotic	1	1
Anti-Ulcer Agents	1	1
Anticonvulsants	1	1
Appetite Stimulants	1	1
Bcl-xL down-regulation	1	1
Cytotoxic	1	1
Gastroprotective	1	1
Heat Shock Protein Inducer	1	1
Multidrug Resistance Gene Modulators	1	1
Nrf2 activation	1	1
P21 Activation	1	1
Photoprotective	1	1
Radiosensitizer	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
STAT3 Inhibitor	1	1
Superoxide Dismutase Up-regulation	1	1

[+]

A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

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Pubmed Data : Helicobacter. 2018 Dec ;23(6):e12535. Epub 2018 Sep 6. PMID: 30191635

Article Published Date : Nov 30, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Cranberry, Curcumin, NAC (N-acetyl-L-cysteine)

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

Pubmed Data : World J Gastroenterol. 2012 Nov 21 ;18(43):6302-7. PMID: 23180952

Article Published Date : Nov 20, 2012

Study Type : Human Study

Additional Links

Substances : Probiotics

Diseases : Helicobacter Pylori Infection

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

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Pubmed Data : Pak J Med Sci. 2018 May-Jun;34(3):616-620. PMID: 30034426

Article Published Date : Apr 30, 2018

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Prunella vulgaris

Diseases : Escherichia coli Infections, Infection: Antibiotic Resistant, Urinary Tract Infections

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

[+]

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

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Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

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Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin, Vitamin D

Diseases : Breast Cancer, Breast Cancer: Metastatic, Chemotherapy-Induced Toxicity: Cyclophosphamide

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

[+]

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Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711

Article Published Date : Mar 10, 2015

Study Type : Human In Vitro

Additional Links

Substances : 6-Shogaol, Gingerol , Pterostilbene

Diseases : Breast Cancer, Breast Cancer Stem Cells

Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

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Pubmed Data : Mol Pharmacol. 2010 Nov ;78(5):855-64. Epub 2010 Aug 16. PMID: 20713551

Article Published Date : Oct 31, 2010

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Amurensin G

Diseases : Breast Cancer: Drug Resistant, Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Doxorubicin

[+]

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

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Pubmed Data : J Cancer Res Clin Oncol. 2015 Sep ;141(9):1511-22. Epub 2014 Dec 28. PMID: 25544670

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Pubmed Data : J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID: 26872471

Article Published Date : Feb 12, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

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Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1921-6. Epub 2014 Jul 22. PMID: 25070704

Article Published Date : Sep 30, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Cyanidin 3-glucoside

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-Tumor, Antiproliferative , apoptosis

Additional Keywords : Drug: Trastuzumab, Natural Substance/Drug Synergy, Supplements

[+]

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

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Pubmed Data : Asian Pac J Trop Med. 2016 11 ;9(11):1084-1088. Epub 2016 Oct 22. PMID: 27890369

Article Published Date : Jan 10, 2016

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

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Pubmed Data : Integr Cancer Ther. 2016 May 5. Epub 2016 May 5. PMID: 27151585

Article Published Date : May 04, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chrysin

Diseases : Carcinoma: Non-Small-Cell Lung, Chemotherapy and Radiation Toxicity, Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemoprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

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Pubmed Data : J Appl Microbiol. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26442997

Article Published Date : Oct 06, 2015

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[+]

Nordihydroguaiaretic acid enhances the activities of aminoglycosides against methicillin- sensitive and resistant Staphylococcus aureus.Dec 31, 2014

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Pubmed Data : Front Microbiol. 2015 ;6:1195. Epub 2015 Oct 27. PMID: 26579101

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nordihydroguaiaretic acid (NDGA)

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Pioglitazone plus nettle has synergistic protective effects against STZ-induced nephropathy.Apr 30, 2017

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Pubmed Data : Food Funct. 2018 Jan 2. Epub 2018 Jan 2. PMID: 29292417

Article Published Date : Jan 01, 2018

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Cachexia: Cancer, Lung Cancer

Pharmacological Actions : Anti-Cachexic Agents, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Quercetin has anti-myeloma activity both in vitro and in vivo.Jun 13, 2016

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Problem Substances : Prednisolone

[+]

The overall results suggest that combination of mangiferin with both metformin and gliclazide alleviates diabetic conditions.Mar 21, 2019

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Pubmed Data : Phytomedicine. 2019 Mar 22 ;59:152901. Epub 2019 Mar 22. PMID: 30981189

Article Published Date : Mar 21, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

The results of this study indicate that dry olive leaf extract possesses strong antimelanoma potential.Apr 14, 2011

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Pubmed Data : Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID: 20568104

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Pubmed Data : BMC Complement Altern Med. 2018 Mar 23 ;18(1):106. Epub 2018 Mar 23. PMID: 29566693

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Pubmed Data : Mol Carcinog. 2017 Mar 30. Epub 2017 Mar 30. PMID: 28370562

Article Published Date : Mar 29, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Malignant Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain.Jul 14, 2016

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Pubmed Data : Life Sci. 2016 Jul 15 ;157:25-31. Epub 2016 May 28. PMID: 27245275

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Pubmed Data : Mar Drugs. 2015 Apr ;13(4):2327-46. Epub 2015 Apr 14. PMID: 25874926

Article Published Date : Mar 31, 2015

Study Type : Review

Additional Links

Substances : Fucoidan, Seaweed: Brown

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Anticarcinogenic Agents, Apoptotic, Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

A review of green tea catechins and their uses in treating infectious diseases. Dec 31, 2017

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Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Antibiotics

[+]

Beta-elemene potentiates the cytotoxic effects of various antineoplastic drugs in cell lines overexpressing the ABCB1 transporter.Jan 31, 2014

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Caffeic acid expands anti-tumor effect of Metformin in human metastatic cervical carcinoma HTB-34 cells.Feb 20, 2017

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Pubmed Data : Anticancer Drugs. 2013 Jul ;24(6):577-86. PMID: 23542749

Article Published Date : Jun 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

Combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death.Oct 31, 2017

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Pubmed Data : Nutr Cancer. 2015 Jul 2:1-11. Epub 2015 Jul 2. PMID: 26134366

Article Published Date : Jul 01, 2015

Study Type : In Vitro Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: Allopurinol, Isothiocyanates, Natural Substance/Drug Synergy

[+]

Combined use of doxycycline and vitamin C could represents a new synthetic-lethal metabolic strategy for eradicating CSCs.Sep 14, 2017

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Curcurmin potentiates the cytotoxic effects of tamoxifen on K562 cells and also decreases the associated cytotoxicity on red blood cells and polymorphonuclear leukocytes.Jul 31, 2013

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Pubmed Data : J Enzyme Inhib Med Chem. 2013 Aug ;28(4):734-40. Epub 2012 Apr 23. PMID: 22524678

Article Published Date : Jul 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Vanillin

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Doxycycline and vitamin C may represent a new synthetic lethal drug combination for eradicating cancer stem cells.Jun 08, 2017

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Pubmed Data : Sci Rep. 2014 Dec 15 ;4:7490. Epub 2014 Dec 15. PMID: 25502402

Article Published Date : Dec 14, 2014

Study Type : In Vitro Study

Additional Links

Substances : Gold (nanoparticles)

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Ferulic acid also demonstrated a synergistic effect in combination with caspofungin against C. albicans.Dec 31, 2017

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Pubmed Data : Br J Cancer. 2012 Jan 17 ;106(2):333-43. Epub 2011 Dec 13. PMID: 22166800

Article Published Date : Jan 16, 2012

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Ovarian Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

[+]

Indole-3-carbinol synergizes with and restores fludarabine sensitivity in chronic lymphocytic leukemia cells .Dec 31, 2015

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Pubmed Data : PLoS One. 2012 ;7(6):e37736. Epub 2012 Jun 29. PMID: 22768036

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

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Substances : Curcumin, Polyphenols, Resveratrol

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Natural Substance/Drug Synergy

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Luteolin and quercetin have a synergistic effect with ceftazidime against S. pyogenes and β-lactamase. Dec 31, 2014

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Pubmed Data : Biomed Res Int. 2015 ;2015:283630. Epub 2015 Aug 19. PMID: 26357651

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

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Substances : Honokiol, Magnolia, Magnolol

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Antimicrobial

Additional Keywords : Dose Response, Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts

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Magnolol and honokiol showed a broad spectrum of synergistic potentiation of conventional antibacterial agents.Dec 31, 2014

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Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):425. Epub 2015 Dec 1. PMID: 26627468

Nordihydroguaiaretic acid might be effective for the development of a novel Helicobacter pylori eradication therapy.Dec 31, 2014

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Pubmed Data : Biomed Res Int. 2015 ;2015:734548. Epub 2015 Apr 6. PMID: 25945343

Phytochemicals and micronutrients may enhance efficacy of doxycycline in combating all the morphological forms of studied Borrelia sp.Dec 31, 2015

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Protolichesterinic acid could be a suitable agent for treatment against HER2-overexpressing breast cancer.Oct 14, 2014

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Pubmed Data : Phytomedicine. 2014 Oct 15 ;21(12):1717-24. Epub 2014 Sep 16. PMID: 25442282

Article Published Date : Oct 14, 2014

Study Type : In Vitro Study

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Substances : Lichens

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance/Drug Synergy

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Pterostilbene could enhance of bactericidal activity of gentamicin.Mar 16, 2017

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Pubmed Data : Molecules. 2017 Mar 17 ;22(3). Epub 2017 Mar 17. PMID: 28304328

Article Published Date : Mar 16, 2017

Study Type : In Vitro Study

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Substances : Pterostilbene

Diseases : Escherichia coli Infections, Pseudomonas aeruginosa, Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

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Pterostilbene, a potential MCR-1 inhibitor that enhances the efficacy of polymyxin B.Jan 15, 2018

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Pubmed Data : Antimicrob Agents Chemother. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29339386

Article Published Date : Jan 15, 2018

Study Type : Review<

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View the Evidence: 338 Abstracts with Natural Substance/Drug Synergy Research

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A review of the beneficial effects of antioxidants on Helicobacter pylori eradication.Nov 30, 2018

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

The addition of probiotics to standard therapy is associated with improved H. pylori eradication rates in both children and adults.Dec 31, 2015

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Adding Berberis vulgaris fruit extract on metronidazole improve the efficacy of bacterial vaginosis therapy.Jul 31, 2016

Adding M. communis extract to metronidazole increases the efficiency of bacterial vaginosis treatment.Feb 28, 2017

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection.Nov 20, 2012

Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection.Apr 30, 2018

Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with benign prostatic hyperplasia.Dec 31, 2016

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Cannabis users report greater pain relief in combination with opioids than when opioids are used alone.Jan 31, 2015

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Curcuminoids with piperine may be used as a safe and effective add on to standard antidepressants in patients with major depressive disorders.Dec 31, 2014

Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation.Nov 20, 2012

Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.Jul 31, 2013

Milled flaxseed lowers total and LDL cholesterol in patients with peripheral artery disease.Mar 31, 2015

Prunella vulgaris may be a potential adjuvant medicine for breast cancer treatment.Dec 31, 2017

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

The addition of POMx to simvastatin therapy in hypercholesterolemic patients improved oxidative stress and lipid status in the patient's serum and in their HMDM. Dec 31, 2013

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The administration of soybean could enhance the response to SSRI anti depressants in menopausal women.Feb 28, 2014

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.Aug 31, 2015

Findings suggest that Plantago ovata husk could be a potentially useful adjuvant in chemotherapy for colorectal cancer.Jun 01, 2012

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Prunella vulgaris has potent anti-Ebola virus activity and may be developed as a novel antiviral approach against EBOV infection.Feb 29, 2016

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Beetroot-carrot juice can be used as an effective treatment for CLL alone or in combination with chlorambucil.Jun 14, 2015

A combination of ascorbate with Amphotericin B is a potentially effective treatment that may reduce nephrotoxicity in patients with systemic candidiasis.Jul 31, 2015

Achillea fragrantissima, rich in flavonoids and tannins, potentiates the activity of diminazine aceturate against Trypanosoma evansi in rats.Feb 29, 2016

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

AGE showed synergistic effects with NTX on inhibition of tumor growth and increment of survival times.Jun 30, 2013

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK.Dec 31, 2016

An extract of Allspice was shown to be effective in decreasing the growth of MB231 tumors by oral administration, and this effect was greater when pretreated with AAE as a chemo-preventive agent.Apr 13, 2015

Anthocyanins work in synergy with trastuzumab by induced apoptosis, inhibited cell growth and affected HER2 downstream signaling.Sep 30, 2014

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics.Jan 31, 2012

Aspalathin from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic mice.Nov 13, 2018

Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.Jul 23, 2017

Calcitriol enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction.Jul 24, 2016

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Chrysin strengthened the therapeutic efficacy of docetaxel and diminished the adverse effect of it.May 04, 2016

Combination of curcumin and mitomycin C can synergistically inhibit tumor growth in MCF-7 breast cancer xenografts and induce apoptosis in breast cancer MCF-7 cells.Dec 31, 2013

Combinational treatment effect of tetrahydrocurcumin and celecoxib on cervical cancer cell-induced tumor growth and tumor angiogenesis.Jun 30, 2016

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.Dec 31, 2013

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels.Dec 31, 2018

Curcumin enhances the activity of fluconazole against Cryptococcus gattii-induced cryptococcosis infection in mice.Oct 06, 2015

Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.Mar 31, 2015

Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence.Oct 14, 2014

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

Evening primrose oil significantly reduced the synovial hyperplasia and inflammatory cells invasion in joint tissues.Sep 30, 2014

Gentamicin in combination with ascorbic acid regulates the severity of Staphylococcus aureus infection-induced septic arthritis in mice.Nov 30, 2012

Ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo.Oct 04, 2014

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

H. procumbens cooperates synergistically with morphine in resolving hyperalgesia and allodynia.May 31, 2016

HU-331 was more active on cancer growth and less toxic for the tumor-bearing host than doxorubicin.Jul 31, 2007

Lactoferrin modified daunorubicin plus honokiol liposomes could be used as a potential therapy for treatment of brain glioma.Jun 02, 2017

Luteolin could restore sensitivity of oxaliplatin resistant cell lines to chemotherapeutic drugs.Dec 31, 2013

Melatonin augments the effects of fluoxetine on depression.Oct 30, 2017

Metformin in combination with curcumin inhibits the growth, metastasis and angiogenesis of hepatocellular carcinoma.Aug 18, 2017

N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection.Mar 31, 2007

Nardostachys jatamansi root extract could increase in the protective index of phenytoin.Nov 30, 2005

Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury.Apr 30, 2017

Natural Substance/Drug Synergy

View the Evidence:
338 Abstracts with Natural Substance/Drug Synergy Research