Paraquat

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3 Problem Substances Researched for Paraquat
NameACCKFocus
Paraquat510Locked
Cesium-13712Locked
Herbicide11Locked
9 Diseases Researched for Paraquat
NameACCKFocus
Parkinson's Disease13Locked
Fibrosis12Locked
Learning disorders12Locked
Neonatal Diseases and Abnormalities12Locked
Oxidative Stress12Locked
Parkinsonism12Locked
Pesticide Toxicity 12Locked
Radiation-Induced Illness: Cesium-137 Exposure12Locked
Herbicide Toxicity11Locked
1 Adverse Pharmacological Actions Researched for Paraquat
NameACCKFocus
Neurotoxic25Locked
2 Substances Researched for Paraquat
NameACCKFocus
Barberry12Locked
Chokeberry11Locked
5 Pharmacological Actions Researched for Paraquat
NameACCKFocus
Anti-Inflammatory Agents12Locked
Interleukin-6 Downregulation12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Antioxidants11Locked
Neuroprotective Agents11Locked

View the Evidence:
40 Abstracts with Paraquat Research

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Parkinson's disease due to laboral exposition to paraquatOct 31, 2012

Pubmed Data : Rev Med Inst Mex Seguro Soc. 2012 Nov-Dec;50(6):665-72. PMID: 23331754
Article Published Date : Oct 31, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Parkinson's Disease
Problem Substances : Paraquat
Adverse Pharmacological Actions : Neurotoxic
[+]

Activated charcoal administrated at 30 minutes after paraquat poisoning can slow down the increased concentration in the plasma.Feb 28, 2017

Pubmed Data : Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 Mar ;29(3):211-215. PMID: 28627339
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Activated Charcoal
Diseases : Chemical Poisoning, Pesticide Toxicity
Pharmacological Actions : Detoxifier
Problem Substances : Paraquat
[+]

Ameliorative effect of crocin on sperm parameters and in vitro fertilization in mice under oxidative stress induced by paraquat.Dec 31, 2019

Pubmed Data : Int J Fertil Steril. 2020 Jan ;13(4):307-314. Epub 2019 Nov 11. PMID: 31710192
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Infertility: Male, Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Paraquat
[+]

Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Reprod Biomed (Yazd). 2019 Dec ;17(11):807-818. Epub 2019 Dec 26. PMID: 31911963
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pesticide Toxicity , Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation
Problem Substances : Paraquat
[+]

Apigenin reverses lung injury and immunotoxicity in paraquat-treated mice.Nov 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Dec ;65:531-538. Epub 2018 Nov 6. PMID: 30408630
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Lung Injury: Acute, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Paraquat
[+]

Astragaloside IV protective effect of against paraquat-induced lung injury.Jan 31, 2016

Pubmed Data : Inflammation. 2016 Feb ;39(1):483-492. PMID: 26452991
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Paraquat
[+]

Bacopa monnieri alleviates paraquat induced toxicity in Drosophila.Nov 30, 2018

Pubmed Data : Neurochem Int. 2018 Dec ;121:98-107. Epub 2018 Oct 5. PMID: 30296463
Article Published Date : Nov 30, 2018
Study Type : Insect Study
Additional Links
Substances : Bacopa
Diseases : Parkinson's Disease, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Paraquat
[+]

Bacopa monnieri supplements offset paraquat-induced behavioural phenotype and brain oxidative pathways in mice.Jan 14, 2019

Pubmed Data : Cent Nerv Syst Agents Med Chem. 2019 Jan 15. Epub 2019 Jan 15. PMID: 30644349
Article Published Date : Jan 14, 2019
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Brain: Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
Problem Substances : Paraquat
[+]

Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0205535. Epub 2018 Nov 5. PMID: 30395570
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fibrosis, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation
Problem Substances : Paraquat
[+]

Berberis vulgaris fruit has beneficial effects in rat pulmonary fibrosis induced by paraquat.Jun 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jul ;81:329-36. Epub 2016 Apr 26. PMID: 27261610
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Barberry
Diseases : Fibrosis, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
Problem Substances : Paraquat
[+]

Chia seeds oil extracts reduce lipid accumulation and produce stress resistance in Caenorhabditis elegans.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2018 ;15:83. Epub 2018 Nov 26. PMID: 30505336
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Chia Seed: Oil
Diseases : Hyperlipidemia, Obesity, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Hypolipidemic
Problem Substances : Paraquat
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Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice.Nov 14, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31732951
Article Published Date : Nov 14, 2019
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Fibrosis, Lung Injury: Acute, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Problem Substances : Paraquat
[+]

Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster.Oct 01, 2018

Pubmed Data : Neurotox Res. 2018 Oct ;34(3):401-416. Epub 2018 Apr 17. PMID: 29667128
Article Published Date : Oct 01, 2018
Study Type : Animal Study
Additional Links
Substances : Catechin
Diseases : Lipid Peroxidation, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
Problem Substances : Paraquat
[+]

Gallic acid could alleviate the noxious effects of paraquat on the antioxidant defense system and renal tissue.Jul 29, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Jul 30. Epub 2020 Jul 30. PMID: 32734364
Article Published Date : Jul 29, 2020
Study Type : Animal Study
Additional Links
Substances : Gallic Acid
Diseases : Kidney Damage: Chemically-Induced, Paraquat Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Paraquat
[+]

Hepatoprotective role of berberine against paraquat-induced liver toxicity in rat.Dec 15, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 16. Epub 2019 Dec 16. PMID: 31845254
Article Published Date : Dec 15, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Chemically-Induced Liver Damage, Pesticide Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Paraquat
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Mucuna pruriens seed extract treatment significantly reduced the Paraquat induced neurotoxicity.May 31, 2013

Pubmed Data : Neurochem Int. 2013 Jun ;62(8):1039-47. Epub 2013 Apr 3. PMID: 23562769
Article Published Date : May 31, 2013
Study Type : Animal Study
Additional Links
Substances : Mucuna pruriens (aka Velvet Beans)
Diseases : Brain: Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents
Additional Keywords : Plant Extracts
Problem Substances : Paraquat
[+]

Neuroprotective effects of avocado peel on paraquat-induced locomotor impairment, lipid peroxidation and shortage of life span.Jul 31, 2019

Pubmed Data : Neurochem Res. 2019 Aug ;44(8):1986-1998. Epub 2019 Jul 15. PMID: 31309393
Article Published Date : Jul 31, 2019
Study Type : Insect Study
Additional Links
Substances : Avacado
Diseases : Cognitive Decline/Dysfunction, Lipid Peroxidation, Pesticide Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Paraquat
[+]

Orally delivered water soluble Coenzyme Q10 blocks on-going neurodegeneration in rats exposed to paraquat.Jan 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Neurosci. 2014 Jan 31 ;15:21. Epub 2014 Jan 31. PMID: 24483602
Article Published Date : Jan 30, 2014
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Paraquat
[+]

Paraquat could negatively influence the learning and memory abilities of developing mice.May 31, 2011

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Jun ;29(6):437-9. PMID: 22096857
Article Published Date : May 31, 2011
Study Type : Animal Study
Additional Links
Diseases : Learning disorders, Oxidative Stress, Pesticide Toxicity
Additional Keywords : Risk Factors
Problem Substances : Paraquat
Adverse Pharmacological Actions : Neurotoxic
[+]

Paraquat induced alteration in the metabolites leads to oxidative stress and neurodegeneration in the exposed organism along with movement disorder.Dec 31, 2015

Pubmed Data : Mol Neurobiol. 2016 Jan ;53(1):254-69. Epub 2014 Nov 27. PMID: 25428622
Article Published Date : Dec 31, 2015
Study Type : Insect Study
Additional Links
Diseases : Oxidative Stress, Parkinsonism
Problem Substances : Paraquat
Adverse Pharmacological Actions : Neurotoxic
[+]

Paraquat induced oxidative damage of the male reproductive system.Feb 28, 2017

Pubmed Data : J Biochem Mol Toxicol. 2017 Mar ;31(3). Epub 2016 Oct 20. PMID: 27762473
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation, Oxidative Stress, Sperm Quality: Low
Pharmacological Actions : Apoptotic
Problem Substances : Paraquat
[+]

Procyanidin B2 protects rats from paraquat-induced acute lung injury.Sep 30, 2018

Pubmed Data : Immunobiology. 2018 Oct ;223(10):555-561. Epub 2018 Jul 6. PMID: 30025709
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Procyanidin B2
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
Problem Substances : Paraquat
[+]

Protective role of thymoquinone against paraquat-induced hepatotoxicity in mice.May 31, 2018

Pubmed Data : Pestic Biochem Physiol. 2018 Jun ;148:16-21. Epub 2018 Mar 13. PMID: 29891368
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Herbicide Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Paraquat
[+]

Tanshinone IIA attenuates paraquat‑induced acute lung injury.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Sep ;18(3):2955-2962. Epub 2018 Jul 16. PMID: 30015919
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Lung Injury: Acute, Pesticide Toxicity
Pharmacological Actions : Cytoprotective
Problem Substances : Paraquat
[+]

The anti-inflammatory effect of hesperetin on lung damage induced by paraquat..May 19, 2018

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 May 20 ;36(5):336-342. PMID: 29996377
Article Published Date : May 19, 2018
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Paraquat
[+]

The results showed that cognitive functions and alterations in the working memory and anxiety levels were detected in mice exposed to cesium-137combined with paraquat exposure. Mar 01, 2015

Pubmed Data : Toxicology. 2015 Mar 2 ;329:73-9. Epub 2015 Jan 17. PMID: 25602925
Article Published Date : Mar 01, 2015
Study Type : Animal Study
Additional Links
Diseases : Learning disorders, Neonatal Diseases and Abnormalities, Radiation-Induced Illness: Cesium-137 Exposure
Additional Keywords : Chernobyl, Environmental Toxicity, Fukushima, Synergistic Toxicity
Problem Substances : Cesium-137, Paraquat
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Therapeutic potential of Origanum vulgare leaf hydroethanolic extract against renal oxidative stress and nephrotoxicity induced by paraquat.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2019 Nov-Dec;9(6):563-573. PMID: 31763215
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Oregano
Diseases : Kidney Damage: Chemically-Induced, Paraquat Toxicity, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Paraquat
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These findings suggest that methylsulfonylmethane as a natural product attenuates paraquat-induced pulmonary and hepatic oxidative injury.Sep 30, 2013

Pubmed Data : Inflammation. 2013 Oct ;36(5):1111-21. PMID: 23595869
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : MSM (Methylsulfonylmethane)
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Paraquat
[+]

This study showed the protective effects of ellagic acid against paraquat-induced nephrotoxicity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Kidney Dis. 2016 Jan ;11(1):23-28. PMID: 28174349
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Pesticide Toxicity
Pharmacological Actions : Cytoprotective, Renoprotective
Problem Substances : Paraquat
[+]

Tualang honey may protect against Paraquat induced toxicity in the rat midbrain and lung.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:4605782. Epub 2017 Jan 3. PMID: 28127418
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Tualang Honey
Diseases : Pesticide Toxicity
Pharmacological Actions : Cytoprotective, Neuroprotective Agents
Problem Substances : Paraquat
[+]

Z. multiflora treatment improved learning and memory impairment as well as lung inflammation and oxidative stress induced by inhaled paraqut.Oct 03, 2019

Pubmed Data : Nutr Neurosci. 2019 Oct 4:1-14. Epub 2019 Oct 4. PMID: 31583983
Article Published Date : Oct 03, 2019
Study Type : Animal Study
Additional Links
Substances : Zataria multiflora
Diseases : Cognitive Decline/Dysfunction, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Paraquat
[+]

Aronia berry concentrate at low doses restores the homeostatic redox environment of neurons treated with paraquat.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:5296271. Epub 2015 Dec 6. PMID: 26770655
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Chokeberry
Diseases : Herbicide Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Herbicide, Paraquat
[+]

Carnosic acid induces anti-inflammatory effects in paraquat-treated SH-SY5Y cells.Dec 31, 2017

Pubmed Data : Mol Neurobiol. 2018 Jan ;55(1):890-897. Epub 2017 Jan 12. PMID: 28083817
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 inducer, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Paraquat
[+]

Chlorogenic acid prevents paraquat-induced apoptosis via Sirt1-mediated regulation of redox and mitochondrial function.May 31, 2019

Pubmed Data : Free Radic Res. 2019 Jun ;53(6):680-693. Epub 2019 Jun 4. PMID: 31106605
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation
Problem Substances : Paraquat
[+]

Ginkgo biloba leaf extract protects HepG2 cells against paraquat-induced oxidative DNA damage.Nov 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2019 Nov 29 ;8(12). Epub 2019 Nov 29. PMID: 31795413
Article Published Date : Nov 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Chemically-Induced Liver Damage, DNA damage, Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Paraquat
[+]

Glyphosate's synergistic toxicity in combination with other factors as a cause of chronic kidney disease of unknown origin.Jul 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2019 Jul 31 ;16(15). Epub 2019 Jul 31. PMID: 31370256
Article Published Date : Jul 30, 2019
Study Type : Review
Additional Links
Diseases : Chronic Kidney Disease (CKD), Glyphosate Toxicity, Kidney Damage: Chemically-Induced
Additional Keywords : Synergistic Toxicity
Problem Substances : Glyphosate, Paraquat
[+]

N-acetylcysteine alleviated paraquat-induced mitochondrial fragmentation and autophagy in primary murine neural progenitor cells.Jul 31, 2019

Pubmed Data : J Appl Toxicol. 2019 Aug 1. Epub 2019 Aug 1. PMID: 31368586
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Neurodegenerative Diseases, Pesticide Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Paraquat
[+]

Paraquat inhibited differentiation in human neural progenitor cells.Feb 29, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Mar ;42:205-11. Epub 2016 Jan 25. PMID: 26878281
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Pesticide Toxicity
Additional Keywords : paraquat, Pesticide Toxicity
Problem Substances : Paraquat
[+]

Sea buckthorn extract may be used as a potential therapeutic agent for the treatment of various oxidative stress-related diseases.Nov 30, 2013

Pubmed Data : Mol Med Rep. 2013 Dec ;8(6):1852-60. Epub 2013 Oct 16. PMID: 24141985
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sea buckthorn
Diseases : Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Gene Expression Regulation, Plant Extracts
Problem Substances : Paraquat
[+]

The tea polyphenol epigallocatechin gallate inhibits Escherichia coli by increasing endogenous oxidative stress.Feb 14, 2017

Pubmed Data : Food Chem. 2017 Feb 15 ;217:196-204. Epub 2016 Aug 26. PMID: 27664626
Article Published Date : Feb 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Escherichia coli Infections
Pharmacological Actions : Anti-Bacterial Agents
Problem Substances : Paraquat

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