Phenolic fractions from Muscadine grape "Noble" pomace can inhibit breast cancer cell MDA-MB-231 better than those from European grape. - GreenMedInfo Summary

Tons of grape pomace which still contained a rich amount of plant polyphenols, is discarded after winemaking. Plant polyphenols have multi-functional activities for human body. In this study, polyphenols of pomaces from Muscadinia rotundifolia"Noble"and Vitis vinifera"Cabernet Sauvignon"were extracted and fractionated, and then they were analyzed with LC-MS and the inhibitory effects on breast cancer cells were compared. The inhibition on MDA-MB-231 cells of fractions from"Noble"was further evaluated. The results showed that polyphenols from 2 grape pomaces could be separated into 3 fractions, and ellagic acid and/or ellagitannins were only detected in fractions from"Noble"pomace. All 3 fractions from"Noble"pomace inhibited MDA-MB-231 better than MCF-7. But fraction 2 from"Cabernet Sauvignon"inhibited MCF-7 better while fraction 1 and fraction 3 inhibited both 2 cells similarly. Moreover, the fractions from"Noble"pomace rather than"Cabernet Sauvignon"can inhibit MDA-MB-231 better. Finally, fractions from"Noble"pomace can induce S-phase arrest and apoptosis on MDA-MB-231. These findings suggested the extracts from grape pomace especially those from"Noble,"are potential to be utilized as health beneficial products or even anti-breast cancer agents.