Chondroprotective

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32 Abstracts with Chondroprotective Research

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A Polyphenol-rich pomegranate fruit extract suppresses NF-κB and IL-6 expression.Mar 08, 2017

Pubmed Data : Phytother Res. 2017 Mar 9. Epub 2017 Mar 9. PMID: 28276100
Article Published Date : Mar 08, 2017
Study Type : Human In Vitro
Additional Links
Substances : Pomegranate
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
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Cytoprotective effects of delphinidin for human chondrocytes against oxidative stress through activation of autophagy.Jan 18, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jan 19 ;9(1). Epub 2020 Jan 19. PMID: 31963866
Article Published Date : Jan 18, 2020
Study Type : Human In Vitro
Additional Links
Substances : Delphinidin
Diseases : Osteoarthritis
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Chondroprotective
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Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Mar 10 ;9(3). Epub 2017 Mar 10. PMID: 28287423
Article Published Date : Mar 09, 2017
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Ginsenosides
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Prostaglandin PGE2 downregulation
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Vitamin C was able to markedly protect the condrocytes against the toxic effects of local anesthetics - ropivacaine, bupivacaine and lidocaine.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Anesthesiol. 2016 Jan-Feb;66(1):29-36. Epub 2015 Oct 9. PMID: 26768927
Article Published Date : Dec 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Vitamin C
Pharmacological Actions : Antioxidants, Chondroprotective
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2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside can be considered as a potential therapeutic for the treatment of postmenopausal osteoporosis.Aug 27, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Aug 28 ;19(9). Epub 2018 Aug 28. PMID: 30154383
Article Published Date : Aug 27, 2018
Study Type : Animal Study
Additional Links
Diseases : Osteoporosis
Pharmacological Actions : Chondroprotective, Osteoprotective
Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts
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Active Vitamin D activates chondrocyte autophagy to reduce osteoarthritis.Dec 08, 2019

Pubmed Data : Biochem Cell Biol. 2019 Dec 9. Epub 2019 Dec 9. PMID: 31815524
Article Published Date : Dec 08, 2019
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Up-regulation, Chondroprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2016 Mar 1 ;24(2):163-70. PMID: 26902085
Article Published Date : Feb 29, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apigenin
Pharmacological Actions : Chondroprotective, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor
Additional Keywords : Gene Expression Regulation
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Apple procyanidins are promising food components that inhibit osteoarthritis progression.May 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 May 8 ;8(1):7229. Epub 2018 May 8. PMID: 29739985
Article Published Date : May 07, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective
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Carnosine had chondroprotective effects on type 2 diabetes mellitus-induced osteoarthritis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:598. Epub 2018 Jun 6. PMID: 29928231
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Carnosine
Diseases : Diabetes Mellitus: Type 2, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective
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Chondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis.Aug 31, 2019

Pubmed Data : J Musculoskelet Neuronal Interact. 2019 Sep 1 ;19(3):362-369. PMID: 31475944
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective
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Epicatechin and scopoletin rich Morinda citrifolia leaf extract supplementation, mitigated OsteoarthritisFeb 28, 2019

Pubmed Data : J Food Biochem. 2019 Mar ;43(3):e12755. Epub 2019 Jan 3. PMID: 31353568
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Epicatechin, Noni
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective
Additional Keywords : Plant Extracts
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Ginsenoside Rb1 has potential for use as a therapeutic agent in osteoarthritis patients.Mar 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2012 Apr ;36(2):161-8. PMID: 23717116
Article Published Date : Mar 31, 2012
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Hydrogen Peroxide Induced Toxicity, Osteoarthritis
Pharmacological Actions : Antioxidants, Chondroprotective
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In vitro effects of cetylated fatty acids mixture from celadrin on chondrogenesis and inflammation with impact on osteoarthritis.Apr 30, 2018

Pubmed Data : Cartilage. 2018 May 1:1947603518775798. Epub 2018 May 1. PMID: 29808705
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Celadrin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Puerarin may serve as a potential target in the treatment of osteoarthritis.Feb 04, 2019

Pubmed Data : Mol Med Rep. 2019 Feb 5. Epub 2019 Feb 5. PMID: 30720093
Article Published Date : Feb 04, 2019
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation
Additional Keywords : Bone Regeneration
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The present data highlights the chondroprotective effects of pomegranate fruit extract consumption.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrition. 2017 Jan ;33:1-13. Epub 2016 Sep 2. PMID: 27908544
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Matrix Metalloproteinase-13 (MMP-13) Inhibitor
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These findings suggest procyanidins can be used to mitigate osteoarthritis pathogenesis.Dec 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Dec 9 ;17(12). Epub 2016 Dec 9. PMID: 27941690
Article Published Date : Dec 08, 2016
Study Type : Animal Study
Additional Links
Substances : Pine Bark Extract
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chondroprotective, osteoarthritis, pine bark extract, Procyanidins, Vascular Endothelial Growth Factor Inhibitors
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These results show that the chondroprotective effects of wogonin are produced by its regulation of the gene expression.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Sep ;23(5):442-8. Epub 2015 Sep 1. PMID: 26336584
Article Published Date : Aug 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Matrix metalloproteinase-3 (MMP-3) inhibitor
Additional Keywords : Gene Expression Regulation
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This study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Sep 30, 2013

Pubmed Data : Eur J Nutr. 2013 Oct ;52(7):1787-99. Epub 2012 Dec 27. PMID: 23269651
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Arthritis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Vitexin alleviates ER-stress-activated apoptosis and the related inflammation in chondrocytes.Nov 13, 2018

Pubmed Data : Food Funct. 2018 Nov 14 ;9(11):5740-5749. PMID: 30321247
Article Published Date : Nov 13, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitexins
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Apoptotic, Chondroprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects.Mar 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 3 ;7:43789. Epub 2017 Mar 3. PMID: 28256567
Article Published Date : Mar 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
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Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm (Lond). 2018 ;15:14. Epub 2018 Jul 20. PMID: 30038551
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin
Diseases : Cartilage Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interferon Gamma Reducer, Interleukin-10 downregulation, Interleukin-4 downregulation
Additional Keywords : Mesenchymal Stem Cells
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Diosmin can maintain the homeostasis of extracellular matrix of articular cartilage.Jul 02, 2019

Pubmed Data : Phytother Res. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31270886
Article Published Date : Jul 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Diosmin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor
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Gypenoside inhibits interleukin-1β-induced inflammatory response in human osteoarthritis chondrocytes.Aug 31, 2017

Pubmed Data : J Biochem Mol Toxicol. 2017 Sep ;31(9). Epub 2017 Apr 19. PMID: 28422402
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gynostemma
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor
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Hydroxytyrosol reduced the expression of NOX and inhibited the inflammatory response caused by Advanced oxidation protein products in chondrocytes.Sep 30, 2019

Pubmed Data : Int J Mol Med. 2019 Oct ;44(4):1531-1540. Epub 2019 Aug 5. PMID: 31432093
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hydroxytyrosol
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Up-regulation, Chondroprotective, SIRT1 Activator
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Liquiritigenin inhibits IL-1β-induced inflammation and cartilage matrix degradation in rat chondrocytes.Sep 04, 2019

Pubmed Data : Eur J Pharmacol. 2019 Sep 5 ;858:172445. Epub 2019 Jun 15. PMID: 31211985
Article Published Date : Sep 04, 2019
Study Type : In Vitro Study
Additional Links
Substances : Liquiritigenin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation
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Melatonin combined with or without exercise prevented periarticular muscle damage as well as cartilage degeneration.Nov 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 14 ;8(57):97633-97647. Epub 2017 Jul 16. PMID: 29228639
Article Published Date : Nov 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Chondroprotective
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Olive and its derivatives show potential in preventing cartilage damage due to osteoarthritis. Sep 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Sep 26 ;9(10). Epub 2017 Sep 26. PMID: 28954409
Article Published Date : Sep 25, 2017
Study Type : Review
Additional Links
Substances : Olive
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective
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Propolis reduces the expression of autophagy-related proteins in chondrocytes under interleukin-1β stimulus.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Aug 1 ;20(15). Epub 2019 Aug 1. PMID: 31374866
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bee Propolis
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Nitric Oxide Inhibitor
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Quercetin may serve as a potential osteoarthritis treatment.Sep 20, 2019

Pubmed Data : Free Radic Biol Med. 2019 Sep 21 ;145:146-160. Epub 2019 Sep 21. PMID: 31550528
Article Published Date : Sep 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation
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Red clover extract has a chondroprotective effect on inflammation and may be a potential preventative agent for osteoarthritis progression.Dec 31, 2017

Pubmed Data : Cells Tissues Organs. 2018 ;206(1-2):95-105. Epub 2019 Jan 31. PMID: 30703768
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Clover
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
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Sesamol has chondroprotective properties.May 11, 2011

Pubmed Data : J Agric Food Chem. 2011 May 11 ;59(9):4969-78. Epub 2011 Mar 23. PMID: 21428299
Article Published Date : May 11, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, NF-kappaB Inhibitor
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Wogonin intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes.Aug 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Aug 25 ;274:13-23. Epub 2017 Jul 5. PMID: 28688942
Article Published Date : Aug 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Interleukin-1 beta downregulation

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