Hepatoprotective

Name	AC	CK
Curcumin	122	261
Coffee	10	98
Ginsenosides	32	56
Vitamin E	10	54
Green Tea	13	51
Anthocyanins	21	47
Thymoquinone	26	47
Resveratrol	25	46
Probiotics	10	43
Nigella sativa (aka Black Seed)	18	42
Polyphenols	23	42
Garlic	13	41
Turmeric	17	41
Vitamin C	21	40
Milk Thistle	11	39
Omega-3 Fatty Acids	7	39
Silymarin	11	38
Spirulina	15	37
Berberine	18	36
Melatonin	20	36
Polyunsaturated Fatty Acids (PUFAs)	3	32
Astaxanthin	17	30
DHA (Docosahexaenoic Acid)	6	28
Fermented Foods and Beverages	10	27
Flavonoids	14	26
Ginger	13	26
NAC (N-acetyl-L-cysteine)	9	25
Quercetin	13	25
Vitamin D	9	25
Guduchi	4	24
Rose	13	24
Zataria multiflora	8	24
Puerarin	12	23
Blue Honeysuckle	11	22
Hydroxytyrosol	7	22
Silibinin	9	22
Fucoidan	11	21
Sulforaphane	8	21
Hibiscus sabdariffa	6	20
Mangiferin	10	20
Naringenin	11	20
Reishi Mushroom	6	20
Tea: Black	1	20
Tea: Green	1	20
Blueberry	10	19
Ellagic Acid	10	19
Artichoke	6	18
Pomegranate	9	18
Catechin	5	17
Citrus naringin	9	17
Lycopene	9	17
Moringa oleifera	10	17
Bilberry	4	16
Black Currant	4	16
Chlorogenic Acid	8	16
Asiatic Acid	8	15
Chokeberry	8	15
Chrysin	8	15
EGCG (Epigallocatechin gallate)	9	15
Olive leaf extract	8	15
Alpha-Lipoic Acid	7	14
Broccoli	3	14
Dandelion	7	14
Flaxseed	3	14
Ginseng (Korean)	4	14
Grape Seed Extract	7	14
Hesperidin	7	14
Honey	7	14
Selenium	7	14
Walnut	7	14
Apigenin	5	13
Luteolin	5	13
Xanthohumol	7	13
Apple Polyphenols	6	12
Black Tea	6	12
Camel Milk	6	12
Cannabidiol	6	12
Crocin	6	12
Fenugreek	6	12
Fisetin	6	12
Gingerol	6	12
Lactobacillus plantarum	6	12
Lotus	7	12
Magnesium	2	12
Sea buckthorn	6	12
Sweet Potato: Purple	6	12
Turmeric: Fermented	2	12
Yoghurt	2	12
Coenzyme Q10	6	11
Diallyl sulfide	6	11
Lychee	6	11
Rosemary	6	11
Royal Jelly	6	11
Shikonin	6	11
Caffeic acid phenethyl ester	5	10
Capsaicin	5	10
Diosmin	5	10
Ginkgo biloba	5	10
Hawthorn	5	10
Holy Basil	1	10
Menatetrenone	1	10
Multivitamin	1	10
Oolong tea	1	10
Rutin	5	10
Strawberry	6	10
Tetrahydrocurcumin	6	10
Ursolic Acid	6	10
Vitamin K2	1	10
Vitamin K2: Menaquinones (MK-4-14)	1	10
Bael	5	9
Garden Cress (Lepidium sativum)	3	9
Genipin	5	9
Ginseng	5	9
Indole-3-Carbinol	5	9
Licorice	5	9
Olive Oil	5	9
Amla Fruit	4	8
Carrot	4	8
Cordyceps sinensis	4	8
Genistein	4	8
Geraniol	4	8
Grape	4	8
Litchi	4	8
Noni	4	8
Oleuropein	4	8
Olive	4	8
Paeoniflorin	4	8
Pomegranate Peel	4	8
Radish	5	8
Solanum nigrum (black nightshade)	4	8
Astragaloside	4	7
Beta-Caryophyllene	4	7
Betulinic acid	4	7
Caffeic Acid	4	7
Carvacrol	4	7
Lactobacillus fermentum	4	7
Lactobacillus rhamnosus GG	4	7
Nettle	4	7
Nobiletin	4	7
Palash	4	7
Panax Notoginseng	4	7
Saffron	4	7
Antrodia camphorata	3	6
Ayurvedic formulation: Liv52	3	6
Beet	3	6
Berries: All	3	6
Bitter Melon	3	6
Blackberry	4	6
Burdock	3	6
Carnosic Acid	3	6
Celery	3	6
Chicory	3	6
Cranberry	3	6
Dates	3	6
Dragon Fruit	3	6
EPA (Eicosapentaenoic Acid)	3	6
Folic Acid	3	6
Hydrogen Water	3	6
Jujube	3	6
Juniper	3	6
Krill	3	6
Lactobacillus paracasei	3	6
Onion	3	6
Passion Flower	3	6
Phosphatidylcholine	3	6
Prickly Pear Cactus	4	6
Propolis: Bee	3	6
Pterostilbene	3	6
Pumpkin Seed Oil/Meal	3	6
Pycnogenol (Pine Bark)	3	6
Sesamol	3	6
Shiitake Mushroom	3	6
Stevia	3	6
White Tea	3	6
Yellow Tea	3	6
Zinc	3	6
Carotenoids	3	5
Fig	3	5
Gallic Acid	3	5
Purslane	4	5
Red Cabbage	3	5
Rosemaric Acid	3	5
Sage	3	5
Tanshinone IIA	4	5
Thistle	4	5
Wheat Grass	3	5
Aloe Vera	2	4
Angelica	2	4
Arctigenin	2	4
Ashwagandha	2	4
Baccharis trimera	2	4
Baicalein	2	4
Barley	2	4
Basil	2	4
Bee Propolis	2	4
Beeswax	2	4
Beta Sitosterol	2	4
Bifidobacterium Longum	2	4
Bitter Apple	2	4
Black Raspberry	2	4
Chaga Mushroom (Inonotus obliquus)	3	4
Chamomile	2	4
Chlorella (Algae)	2	4
Choline	2	4
Citrus Peel	2	4
Coconut Water	2	4
Cordyceps Militaris	2	4
Coriandrum sativum	2	4
Corn: Purple	2	4
D-Limonene	2	4
Date Seeds	2	4
Dill	2	4
Embelia ribes	2	4
FOS (Fructooligosaccharides)	2	4
Flaxseed Oil	2	4
Garlic: Aged	2	4
Gastrodin	2	4
Ginseng (American)	2	4
Glycyrrhizin	2	4
Goji	2	4
Henna	2	4
Horehound	2	4
Hu Zhang (Polygonum cuspidatum)	2	4
Isoliquiritigenin	2	4
Kimchi	2	4
Lignans	3	4
Lingonberry	2	4
Lutein	2	4
Marjoram	2	4
Myricetin	2	4
Panax Ginseng	2	4
Piceatannol	2	4
Piperine	2	4
Policosanol	2	4
Pomegranate Seed	2	4
Potato	2	4
Procyanidin B2	2	4
Pumpkin Seeds	2	4
Rhubarb	2	4
Salvia miltiorrhiza	2	4
Stigmasterol	2	4
Syrian rue	2	4
Tamarind	3	4
Taurine	2	4
Thyme	2	4
Verbascoside	2	4
Vitex negundo	2	4
Yeast	2	4
Allicin	2	3
Astragalus	2	3
Barberry	2	3
Bee Venom	2	3
Cannabinoids	2	3
Cryptoxanthin	2	3
Cucumber	2	3
Diosgenin	2	3
Ferulic acid	2	3
Honokiol	2	3
Huperzine	2	3
Kudzu	2	3
Lion's Mane (Hericium Erinaceus)	2	3
Mulberry	2	3
Oleanolic acid	2	3
Phloretin	2	3
Phyllanthus urinaria	2	3
Pine Bark Extract	2	3
Punicalagin	2	3
Thymol	2	3
Water: Deep Sea	2	3
2-Methoxyestradiol	1	2
6-Shogaol	1	2
Acai	1	2
Ajwain	1	2
Almond	1	2
Amygdalin (laetrile)	1	2
Andrographis	1	2
Anise	1	2
Apocynin	1	2
Apple Cider Vinegar	1	2
Apples	1	2
Apricot	1	2
Apricot Kernel	1	2
Arginine	1	2
Artesunate	1	2
Asparagus	1	2
Avocado	1	2
Bacopa	1	2
Bamboo	1	2
Banana Peel	1	2
Banana Stem	1	2
Bay leaf	1	2
Berbamine	1	2
Bisdemethoxycurcumin	1	2
Bitter Orange	1	2
Black Tea Theaflavins	1	2
Boron	1	2
Broccoli Sprouts	1	2
Bromelain	1	2
Butterbur	1	2
Caffeine	1	2
Calcium	1	2
Cannabis	1	2
Carnosine	1	2
Celery Oil	1	2
Celery seed	1	2
Celosia cristata (cockscomb)	1	2
Centella asiatica	1	2
Cherry: All Varieties	1	2
Chickpea	1	2
Chrysanthemum Indicum	1	2
Cinnamon	1	2
Cissus quadrangularis	1	2
Cloudberry	1	2
Cocoa Butter	1	2
Coconut Oil	1	2
Coffee: Green/Unroasted	1	2
Copper	1	2
Coptidis rhizoma	1	2
Crowberry	1	2
Cucurbitacin B	1	2
Cucurbitacin E	1	2
Cumin	1	2
Cysteine (see N-Acetylcysteine)	1	2
Dibenzoylmethane (DBM)	1	2
Earthworms	1	2
Echinacea	1	2
Eggplant	1	2
Elderberry	1	2
Emodin	1	2
Eriodictyol	1	2
Feijoa	1	2
Feverfew	1	2
Fish Oil	1	2
Flowers	1	2
Frankincense	1	2
Fruit: All	1	2
Gamma-Oryzanol	1	2
Gardenia	1	2
Geranium	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Guarana	1	2
Guava	1	2
Gynostemma	2	2
Helenalin	1	2
Hibiscus rosa-sinensis	1	2
Histidine	1	2
Homeopathic Medicine: All	1	2
Homeopathic Medicine: Lycopodium	1	2
Honeydew (melon)	1	2
Hops	1	2
Humic Acid	1	2
Isoquercitrin	1	2
Kefir	1	2
Kombucha Tea	2	2
Lactobacillus casei	1	2
Lactobacillus casei: Shirota	1	2
Lactobacillus probiotics	1	2
Lactobacillus reuteri	1	2
Lactobacillus rhamnosus	1	2
Lactobacillus salivarius	1	2
Lecithin	1	2
Ligustrazine	1	2
Linden (Tilia)	1	2
Long Pepper	1	2
Loquat	1	2
Loquat Seeds	1	2
MSM (Methylsulfonylmethane)	1	2
Maca	1	2
Magnesium Sulfate	1	2
Magnolol	1	2
Maitake Mushroom	1	2
Mango	1	2
Mangosteen	1	2
Manuka Honey	1	2
Mastic gum	1	2
Medicinal Mushrooms	1	2
Medium Chain Triglycerides	1	2
Mint	1	2
Miso	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Myrica rubra	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Nutmeg	1	2
Oak	1	2
Oats	1	2
Okra	1	2
Oleic acid	1	2
Olives	1	2
Orange	1	2
Oregano	1	2
Oyster Mushroom	1	2
Palmitoylethanolamide	1	2
Papaya	1	2
Papaya: Fermented	1	2
Parsley	1	2
Parthenolide	1	2
Pectin	1	2
Peppermint	1	2
Phellinus Linteus	2	2
Phospholipids	1	2
Phyllanthus emblica	1	2
Pine Needle	1	2
Pine Nut	1	2
Piper cubeba (Cubeb)	1	2
Plant Stem Cells	1	2
Plantago	1	2
Plantago major	1	2
Pleurotus nebrodensis	1	2
Proanthocyanidins	1	2
Protein Supplement	1	2
Pterocarpus marsupium	1	2
Pueraria mirifica	1	2
Purple Carrots	1	2
Rambutan	1	2
Raspberry	1	2
Red Sage	1	2
Rice	1	2
Rice Bran	1	2
Rice: Brown	1	2
Rice: Parboiled	1	2
Rooibos	1	2
Rose Hips	1	2
Rosmarinic acid	1	2
SAMe (S-adenosylmethionine)	1	2
Saikosaponin	1	2
Sessile Joyweed	1	2
Shallot	1	2
Skullcap: Chinese	1	2
Soy	1	2
Soybean: Black	1	2
Spearmint	1	2
St. Johns Wort	1	2
Star Fruit	1	2
Stilbenes	1	2
Sweet Cherry	1	2
Sweet Potato	1	2
Tannic Acid	1	2
Taro	1	2
Toona sinensis	1	2
Tribulus	1	2
Tyrosine	1	2
Vanillin	1	2
Virgin Coconut Oil	1	2
Vitamin E: Gamma-tocotrienol	1	2
Vitamin E: alpha tocopherol	1	2
Vitexins	1	2
Water: Deuterium Depleted	1	2
Water: Electrolyzed Reduced	1	2
Watercress	1	2
Xanthones	1	2
Yellow Sweet Clover (Melilotus officinalis)	1	2
Zerumbone	1	2
Agrimony	1	1
Beta-Elemene	1	1
Caraway	1	1
Cocoa	1	1
Coriandor	1	1
Crimini Mushroom	1	1
Curcuminoids	1	1
Cyperus longus	1	1
Eugenol	1	1
Fucoxanthin	1	1
Haritaki (Terminalia chebula)	1	1
Lavender	1	1
Lupeol	1	1
Methionine	1	1
Mugwort	1	1
Mushrooms: All	1	1
Muskmelon	1	1
Mustard: Field/Turnip	1	1
Persimmon	1	1
Prebiotics	1	1
Rice: Black	1	1
Vitamin A	1	1
White Mulberry	1	1
Wormwood	1	1

[+]

Coffee consumption can significantly reduce the risk for hepatic fibrosis and cirrhosis.Dec 31, 2014

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Pubmed Data : Clin Gastroenterol Hepatol. 2016 May 4. Epub 2016 May 4. PMID: 27155553

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Pubmed Data : Clin Nutr. 2016 Mar 30. Epub 2016 Mar 30. PMID: 27060021

Article Published Date : Mar 29, 2016

Study Type : Meta Analysis, Review

Additional Links

Substances : Coffee, Tea: Black, Tea: Green

Diseases : Metabolic Diseases, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Risk Reduction

[+]

These results found a significantly decreased risk of NAFLD among coffee drinkers and significantly decreased risk of liver fibrosis.Nov 06, 2016

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Pubmed Data : Eur J Gastroenterol Hepatol. 2016 Nov 7. Epub 2016 Aug 7. PMID: 27824642

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Pubmed Data : Medicine (Baltimore). 2015 May ;94(20):e758. PMID: 25997043

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Pubmed Data : Pak J Med Sci. 2017 Jul-Aug;33(4):931-936. PMID: 29067068

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Pubmed Data : Transplant Proc. 2008 Nov;40(9):2978-80. PMID: 19010165

Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID: 28071871

Article Published Date : Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Case Reports Hepatol. 2014 ;2014:697359. Epub 2014 Sep 3. PMID: 25374729

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Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : Fig

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Isoniazid, Paracetamol

[+]

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."Oct 01, 2006

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Pubmed Data : Mol Cell Biochem. 2006 Oct ;290(1-2):61-7. Epub 2006 Aug 26. PMID: 16937016

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Pubmed Data : J Steroid Biochem Mol Biol. 2016 Apr 12. Epub 2016 Apr 12. PMID: 27084531

Pubmed Data : Phytomedicine. 2019 Jan 9 ;58:152824. Epub 2019 Jan 9. PMID: 30836218

Article Published Date : Jan 08, 2019

Study Type : Animal Study

Additional Links

Substances : Kudzu, Milk Thistle

Diseases : Alcoholic Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic

[+]

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

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Pubmed Data : Folia Morphol (Warsz). 2019 Mar 5. Epub 2019 Mar 5. PMID: 30835338

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Pubmed Data : Phytother Res. 2015 Oct ;29(10):1577-84. Epub 2015 Jul 14. PMID: 26178909

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Pubmed Data : J Pak Med Assoc. 2016 Jul ;66(7):859-63. PMID: 27427136

Article Published Date : Jun 30, 2016

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Pubmed Data : Int Immunopharmacol. 2018 Jan ;54:125-130. Epub 2017 Nov 9. PMID: 29128856

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Can J Physiol Pharmacol. 2017 Sep ;95(9):1046-1057. Epub 2017 Jun 30. PMID: 28666094

Article Published Date : Aug 31, 2017

Study Type : Animal Study

Additional Links

Substances : Ginseng (American)

Diseases : Alcohol Toxicity , Dyslipidemias, Fatty Liver, Metabolic Syndrome X

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Allicin have the effective hepato-protection on ethanol-induced hepatotoxicity.Nov 29, 1998

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Pubmed Data : Wei Sheng Yan Jiu. 1998 Nov 30 ;27(6):415-7. PMID: 11939034

Article Published Date : Nov 29, 1998

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Alcoholic Liver Disease

Pharmacological Actions : Hepatoprotective

[+]

Allium fistulosum attenuates the development of NAFLD.Mar 31, 2018

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Pubmed Data : Int J Mol Sci. 2019 Apr 3 ;20(7). Epub 2019 Apr 3. PMID: 30987167

Article Published Date : Apr 02, 2019

Study Type : Animal Study

Additional Links

Substances : Spinach

Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.Jan 19, 2017

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Pubmed Data : Nagoya J Med Sci. 2015 Feb ;77(1-2):145-53. PMID: 25797979

Pubmed Data : Nat Prod Res. 2016 Mar ;30(6):715-9. Epub 2015 May 15. PMID: 25978515

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Tamarind

Pharmacological Actions : Hepatoprotective

Problem Substances : Tubercular Drugs

[+]

An extract of Fragaria ananassa had a protective effect against cadmium chloride toxicity upon the liver. Jan 21, 2017

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Pubmed Data : Toxicol Mech Methods. 2017 Jan 22:1-27. Epub 2017 Jan 22. PMID: 28110594

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Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Article Published Date : Dec 31, 2013

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Pubmed Data : J Ethnopharmacol. 2016 Dec 4 ;193:169-178. Epub 2016 Aug 4. PMID: 27497636

Article Published Date : Dec 03, 2016

Study Type : Animal Study

Additional Links

Substances : Angelica

Diseases : Anemia

Therapeutic Actions : Exercise

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Hepatoprotective, Interleukin-6 Downregulation

[+]

Anise seed possesses protective effects against carbon tetrachloride (CCl4)-induced toxicity.Jan 31, 2015

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Pubmed Data : Iran J Basic Med Sci. 2015 Feb ;18(2):205-11. PMID: 25825639

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Anise

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Essential Oils

[+]

Anthocyanin from Lonicera caerulea can be used as a dietary health supplement for alcoholic steatohepatitis.Jun 09, 2019

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[+]

Antidiabetic activity and chemical composition of Sanbai melon seed oil.Dec 31, 2017

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Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:5434156. Epub 2018 May 2. PMID: 29853958

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Pubmed Data : BMC Complement Altern Med. 2017 Jan 18 ;17(1):56. Epub 2017 Jan 18. PMID: 28100199

Article Published Date : Jan 17, 2017

Study Type : Animal Study

Additional Links

Substances : Henna

Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : J Intercult Ethnopharmacol. 2016 Jan-Feb;5(1):27-35. Epub 2016 Jan 27. PMID: 27069723

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Papaya

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Aqueous extracts of leaves of R. sativus offer partial protection against hepatotoxicity induced by carbon tetrachloride.Dec 31, 2013

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Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Morphine

[+]

Baicalein could ameliorate liver I/R injury via induction of HO-1-mediated autophagy.Dec 31, 2015

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Pubmed Data : Sci Rep. 2016 ;6:25042. Epub 2016 May 6. PMID: 27150843

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Baicalein

Diseases : Liver Injury: Ischemia/reperfusion

Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective

[+]

Baicalein executed a kidney-protection action in hyperuricemia and therefore may be used as a therapeutic alternative for hyperuricemic nephropathy.Jun 19, 2017

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Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:614580. Epub 2013 Jun 3. PMID: 23818929

Article Published Date : Dec 31, 2012

Study Type : Animal Study

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Substances : Honey

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Metanil-Yellow Dye

Adverse Pharmacological Actions : Hepatotoxic

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Beeswax contains long-chain alcohols which have a preventive effect against chemically-induced liver damage in mice. Jun 01, 2007

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Pubmed Data : J Med Food. 2007 Jun;10(2):379-83. PMID: 17651079

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Substances : Beeswax

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

[+]

Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats.May 31, 2012

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Pubmed Data : Food Chem Toxicol. 2012 Jun ;50(6):2027-33. Epub 2012 Mar 24. PMID: 22465004

Article Published Date : May 31, 2012

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2018 Mar 2. Epub 2018 Mar 2. PMID: 29505790

Article Published Date : Mar 01, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Hypolipidemic

[+]

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.Mar 07, 2019

Click here to read the entire abstract

Pubmed Data : FASEB J. 2019 Mar 8:fj201802316R. Epub 2019 Mar 8. PMID: 30848932

Article Published Date : Mar 07, 2019

Study Type : Animal Study

Additional Links

Substances :

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Coffee consumption can significantly reduce the risk for hepatic fibrosis and cirrhosis.Dec 31, 2014

Coffee consumption could lower the risks of liver cancers, liver diseases and liver cirrhosis.Dec 31, 2015

Green tea intake reduces the risk of liver disease.Dec 31, 2014

Physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD.May 03, 2016

Polyunsaturated fatty acids supplementation can improve liver steatosis and liver functions.Dec 22, 2016

Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

Studies on coffee and NAFLD suggest that coffee consumption could have a protective role on fibrosis.Mar 29, 2016

These results found a significantly decreased risk of NAFLD among coffee drinkers and significantly decreased risk of liver fibrosis.Nov 06, 2016

Vitamin E significantly improved liver function and histologic changes in patients with NAFLD/NASH.Jun 30, 2015

8 weeks of provision of a diet low in free sugar content compared with usual diet resulted in significant improvement in hepatic steatosis.Jan 21, 2019

A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients. Apr 30, 2015

A multivitamin and phospholipids complex protects the hepatic cells from androgenic-anabolic-steroids-induced toxicity.Jan 01, 2008

A probiotic yogurt demonstrates a significant rate of minimal hepatic encephalopathy reversal. Jul 01, 2008

A vitamin K2 preparation inhibits the development of liver cancer in patients with type C cirrhosis. Sep 01, 2010

An improved diet is particularly important for individuals with a high genetic risk for NAFLD.Mar 27, 2018

Artichoke leaf extracts have benefits in the management of NASH.Dec 31, 2015

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD.Nov 30, 2018

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea Jan 30, 2018

Consumption of hibiscus sabdariffa extracts reduced obesity, abdominal fat, serum FFA and improved liver steatosis.Mar 31, 2014

Curcuma longa (turmeric) and tinospora cordifolia (guduchi) prevents antibiotic-induced liver damage in patients with tubercolosis. Aug 14, 2008

Curcumin alleviates ethanol-induced oxidative damage in liver cells. Jan 18, 2010

Curcumin prevented the development of immunological alterations in NAFLD.Dec 31, 2016

Curcumin-galactomannoside complex offered significant hepatoprotective effects to attenuate alcohol induced alterations to hepatic function markers.Dec 31, 2017

DHA supplementation improves liver steatosis in children with NAFLD. Oct 31, 2013

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity.Mar 14, 2017

Fermented garlic extracts might be effective and safe management options for mild hepatic dysfunction.Jul 31, 2017

Fermented turmeric powder is well-tolerated and effective in subjects with elevated alanine transaminase levels.Dec 31, 2012

Flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.May 31, 2016

Fructose restriction decreased liver fat, visceral fat, and de novo lipogenesis, and improved insulin kinetics in children with obesity.May 31, 2017

Garlic may reduce the amount of fat in the liver and prevent or delay the progression of NAFLD.Dec 31, 2015

Green tea extract therapy resulted in significant improvement in metabolic, chemical, inflammatory and radiological parameters of NAFLD patients.Jun 30, 2017

Hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD.Jun 30, 2019

High intake of magnesium may be associated with reduced risks of fatty liver disease and prediabetes.Apr 01, 2018

Higher coffee consumption was associated with lower risk of elevated aminotransferase concentration in Korean adults.Nov 30, 2016

Korean Red Ginseng could be used as a complementary therapy for chronic hepatitis B.Nov 30, 2016

Maintenance of high cardiorespiratory fitness and stability of body weight are critical public health considerations for the treatment of NAFLD.Jul 20, 2016

n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.Jun 04, 2015

N-acetyl cysteine may have a protective effect against reperfusion injury in liver transplant recipients. Nov 01, 2008

N. sativa seed oil seems to be safe and improve liver steatosis and injury and blood levels of triglycerides, LDL-C and HDL-C in the NAFLD patients.Apr 23, 2019

Probiotic compounds can be effective in improving pediatric NAFLD.Oct 12, 2016

Short-term supplementation with Curcumin led to an improvement in different features of NAFLD.Jun 07, 2016

Short-term vitamin E treatment significantly improves abnormal liver enzyme levels in NAFLD patients with metabolic syndrome.Nov 30, 2015

Silibinin could be beneficial in preventing drug-induced liver injury in tuberculosis treatments. Dec 31, 2014

Silymarin has an efficacy to prevent liver injury from standard combined antituberculosis drugs without significant adverse effects.Dec 31, 2014

Silymarin in high dose is a good choice for improvement of liver biochemical profile and QoL in chronic hepatitis C virus cirrhotic patients.Oct 31, 2017

Supplementation at a high dosage of 6 g daily in NAFLD patients has strong and multiple beneficial metabolic effects and improves their health-related quality of life.Dec 31, 2013

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

The present intervention demonstrated the antioxidation, anti-aging and hepatoprotective nature of Ganoderma lucidum.Nov 30, 2017

These observations clearly indicate the beneficial effects of O. sanctum on various biochemical parameters in young overweight or obese subjects.Jun 30, 2017

Tinospora cordifolia has a protective effect on hepatic and gastrointestinal toxicity induced by chronic and moderate alcoholism.Dec 31, 2015

Treatment of non-alcoholic steatohepatitis patients with vitamin D.Sep 28, 2018

Vitamin E and C intake may be protective from NAFLD-related liver damage.Jul 03, 2019

Vitamin E and hydroxytyrosol may be a promising strategy that could be easily diet integrated to improve NAFLD-related liver damage in children.Feb 10, 2019

Yogurt improves insulin resistance and liver fat in obese women with nonalcoholic fatty liver disease and metabolic syndrome.May 31, 2019

Zataria multiflora supplementation for 12 weeks improved insulin resistance in patients with NAFLD.Nov 30, 2018

Apigenin and Luteolin significantly activate the PI3K/Nrf2/ARE system, and this activation may be responsible for their anti-inflammatory effects.Apr 21, 2015

Curcumin could modulate hepatocyte epithelial-mesenchymal transition implicated in treatment of liver fibrosis.Aug 23, 2015

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

The study suggests the cytoprotective effects of Lepidium sativum seed against H2O2-induced toxicity in HepG2.Dec 31, 2015

A case report of severe alcoholic hepatitis effectively treated with vitamin E as an add-on to corticosteroids.Oct 10, 2017

After taking 30 mg artichoke leaf extract tea 3 times a day, patients bilirubin levels significantly declined at the end of the first week and all liver function tests were normalized within 2 months. Dec 31, 2013

A diet rich in vitamin C and quercetin could prevent nicotine-induced toxicity.Nov 30, 2016

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."Oct 01, 2006

6-gingerol ameliorates age-related hepatic steatosisDec 31, 2018

6-gingerol ameliorates age-related hepatic steatosis.Dec 31, 2018

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced liver damage in mice.Nov 01, 2011

6-shogaol can be used as a therapeutic agent for preventing complications in diabetic patients.Dec 31, 2018

A broccoli extract enriched diet increases antioxidant enzyme activities and exerts an antioxidant effect towards cholesterol oxidation in rat liver.Apr 11, 2016

A combination of five main alkaloids from Rhizoma Coptidis showed a synergetic cholesterol-lowering efficacy.Apr 14, 2016

Hepatoprotective

View the Evidence:
1484 Abstracts with Hepatoprotective Research