Hypoxia-inducible factor-1 (HIF-1) inhibitor

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4 Substances Researched for Hypoxia-inducible factor-1 (HIF-1) inhibitor

Name	AC	CK
Apigenin	1	1
Fisetin	1	1
Luteolin	1	1
Quercetin	1	1

Research Articles 1
Cumulative Knowledge Score 1
Overall Research Rating GOOD

View the Evidence:
22 Abstracts with Hypoxia-inducible factor-1 (HIF-1) inhibitor Research

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View the Evidence: 22 Abstracts with Hypoxia-inducible factor-1 (HIF-1) inhibitor Research

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Increased tumor ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1.Dec 31, 2013

Resveratrol may improve some outcomes of PCOS patients.Jul 20, 2019

Amurensin G had significant antiangiogenic and antitumor growth effects in tamoxifen resistant breast cancer.Sep 30, 2012

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Wogonin decreased the expression of glycolysis-related proteins, glucose uptake and lactate generation in a dose-dependent manner.Jan 31, 2014

Restoration of ascorbate from adequate to optimal physiological levels reduced tumor growth rates and moderated HIF-1 pathway activityJan 31, 2015

Curcumin prevents chronic intermittent hypoxia-induced myocardial injury. Dec 31, 2019

EGCG can be developed into a potential agent for the prevention and treatment of smoking‑associated NSCLC.May 31, 2015

Partridgeberry polyphenols significantly induced a decline in OGD/R injury-triggered apoptosis in vitro, suppressed the inflammatory biomarkers in primary neurons following hypoxic injury.May 04, 2015

Tetrahydrocurcumin demonstrated an inhibitory effect against tumor angiogenesis in CaSki-implanted nude mice model.Dec 31, 2014

The anti-neoplastic activity of nobiletin was due to its ability to inhibit angiogenesisMay 31, 2015

These results support the suppression of the hypoxic response by ascorbate as a plausible mechanism of action of its anti-tumour activity.Aug 23, 2016

Procyanidin B2 gallate regulates TNF-α production from T cells through inhibiting glycolytic activity via mTOR-HIF-1 pathway.Jun 30, 2020

A ketogenic diet attenuates proliferation and stemness of glioma stem‑like cells by altering metabolism resulting in increased ROS production.Jan 31, 2020

Apigenin as tumor suppressor in cancers: biotherapeutic activity, nanodelivery, and mechanisms with emphasis on pancreatic cancer.Dec 31, 2019

Baicalein inhibits MCF-7 cell proliferation In vitro and induces radiosensitivity.Dec 31, 2014

Baicalin attenuated the abnormal proliferation of HPASMCs through suppression of the HIF-1α and AhR pathways.Sep 30, 2014

Chlorogenic acid may act as a chemosensitizing agent leading to cancer growth suppression.Dec 31, 2017

Low tumor tissue ascorbate levels were associated with high HIF-1 activation and tumor growth.Jul 14, 2010

Luteolin impairs hypoxia adaptation and progression in human breast and colon cancer cells. Jun 07, 2020

Silver nano particles might be a promising anticancer treatment that counteracts the shortcomings of current cancer therapy.Dec 31, 2015

The flavonoids apigenin, luteolin, fisetin and quercetin inhibit hypoxia-induced VEGF expression, which is associated with angiogenesis and cancer promotion. Feb 10, 2010

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Hypoxia-inducible factor-1 (HIF-1) inhibitor

View the Evidence:
22 Abstracts with Hypoxia-inducible factor-1 (HIF-1) inhibitor Research