Immunomodulatory: Th17 downregulation

Name	AC	CK
Arctigenin	2	4
Burdock	2	4
Ginseng (Korean)	2	4
Cannabidiol	2	3
Acetic Acid	1	2
Astragalus	1	2
Cannabis	1	2
Cinnamon	1	2
DHA (Docosahexaenoic Acid)	1	2
Delta-tetrahydrocannabinol (THC)	1	2
EGCG (Epigallocatechin gallate)	1	2
Ginsenosides	1	2
Mangiferin	1	2
Peony	1	2
Vinegar	1	2
Curcumin	1	1
Probiotics	1	1
Resveratrol	1	1

[+]

Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis.Oct 12, 2017

Click here to read the entire abstract

Pubmed Data : Benef Microbes. 2017 Oct 13 ;8(5):833-840. Epub 2017 Oct 12. PMID: 29022387

Article Published Date : Oct 12, 2017

Study Type : Human Study

Additional Links

Substances : Lactobacillus plantarum

Diseases : Atopic Dermatitis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Interferon Gamma Reducer, Interleukin-4 downregulation

[+]

Oral administration of Zataria multiflora extract decreases IL-17 expression in perennial allergic rhinitis.Mar 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Rep Biochem Mol Biol. 2018 Apr ;6(2):203-207. PMID: 29766004

Article Published Date : Mar 31, 2018

Study Type : Human Study

Additional Links

Substances : Zataria multiflora

Diseases : Allergic Rhinitis

Pharmacological Actions : Immunomodulatory: Th17 downregulation

[+]

These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis.Sep 14, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cells. 2019 Sep 15 ;8(9). Epub 2019 Sep 15. PMID: 31540162

Article Published Date : Sep 14, 2019

Study Type : Human In Vitro

Additional Links

Substances : Fisetin

Diseases : Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, Interferon Gamma Reducer

[+]

Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance.Apr 30, 2011

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Pubmed Data : J Mol Neurosci. 2011 May ;44(1):31-40. Epub 2011 Jan 19. PMID: 21246417

Article Published Date : Apr 30, 2011

Study Type : Animal Study

Additional Links

Substances : Beta-Elemene

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation

[+]

Arctigenin ameliorates colitis through down-regulating the differentiation of Th1 and Th17 cells via mTORC1 pathway. Aug 14, 2015

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Pubmed Data : Biochem Pharmacol. 2015 Aug 15 ;96(4):323-36. Epub 2015 Jun 11. PMID: 26074264

Article Published Date : Aug 14, 2015

Study Type : Animal Study

Additional Links

Substances : Arctigenin, Burdock

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Arctigenin may have anti-inflammatory and immunosuppressive properties via inhibiting Th17 cells.Oct 05, 2015

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Pubmed Data : Mol Neurobiol. 2015 Oct 6. Epub 2015 Oct 6. PMID: 26440666

Article Published Date : Oct 05, 2015

Study Type : Animal Study

Additional Links

Substances : Arctigenin, Burdock

Diseases : Autoimmune Diseases, Brain Inflammation , Multiple Sclerosis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Immunosuppressive Agents

[+]

Astragalus polysaccharide exerts an effective therapeutic effect against experimental colitis by recovering the functional status of Treg cells.Mar 20, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2016 Mar 21 ;22(11):3175-85. PMID: 27003994

Article Published Date : Mar 20, 2016

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Autism is associated with dysregulation of transcription factor signalling that can be corrected by resveratrol treatment in mice. Aug 29, 2016

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Pubmed Data : Mol Neurobiol. 2016 Aug 30. Epub 2016 Aug 30. PMID: 27578011

Article Published Date : Aug 29, 2016

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Autism, Immune Dysregulation: TH1/TH2 imbalance

Pharmacological Actions : Immunomodulatory: Th17 downregulation, MicroRNA modulator

[+]

Berberine has anti-inflammatory effects on H. pylori-induced chronic gastritis.Jan 17, 2018

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Pubmed Data : J Cell Biochem. 2018 Jan 18. Epub 2018 Jan 18. PMID: 29345340

Article Published Date : Jan 17, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Berberine prevents ulcerative colitis by modifying gut microbiota and regulating the balance of Treg/Th17.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Front Pharmacol. 2018 ;9:571. Epub 2018 May 31. PMID: 29904348

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Ulcerative Colitis

Pharmacological Actions : Immunomodulatory: Th17 downregulation

Additional Keywords : Microbiota

[+]

Cucurbitacin E ameliorates acute graft-versus-host disease.Sep 17, 2018

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Pubmed Data : Immunol Lett. 2018 Sep 18 ;203:62-69. Epub 2018 Sep 18. PMID: 30240636

Article Published Date : Sep 17, 2018

Study Type : Animal Study

Additional Links

Substances : Cucurbitacin E

Diseases : Graft vs Host Disease

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, STAT3 Inhibitor

[+]

Docosahexaenoic acid Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis suppresses experimental autoimmune encephalomyelitis.Sep 18, 2010

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Pubmed Data : Brain Behav Immun. 2010 Sep 18. Epub 2010 Sep 18. PMID: 20854895

Article Published Date : Sep 18, 2010

Study Type : Animal Study

Additional Links

Substances : DHA (Docosahexaenoic Acid)

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory: Th17 downregulation

[+]

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

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Pubmed Data : J Leukoc Biol. 2016 Mar 8. Epub 2016 Mar 8. PMID: 26957211

Article Published Date : Mar 07, 2016

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Heme oxygenase-1 up-regulation, Immunomodulatory: Th17 downregulation, NF-E2-Related Factor-2 (Nrf2) Modulator, STAT3 Inhibitor

[+]

Flos Abelmoschus manihot extract attenuates DSS-induced colitis by regulating gut microbiota and Th17/Treg balance.Aug 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Sep ;117:109162. Epub 2019 Jun 26. PMID: 31254739

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Substances : Okra

Diseases : Colitis

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Gallic acid may be used as a therapeutic agent for allergic rhinitis.Mar 14, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Mar 15 ;70:512-519. Epub 2019 Mar 15. PMID: 30884431

Article Published Date : Mar 14, 2019

Study Type : Animal Study

Additional Links

Substances : Gallic Acid

Diseases : Allergic Rhinitis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 downregulation

[+]

Hydrogen rich water may have great potential in the treatment of Multiple sclerosis.May 14, 2016

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Pubmed Data : J Neuroimmunol. 2016 May 15 ;294:6-13. Epub 2016 Mar 14. PMID: 27138092

Article Published Date : May 14, 2016

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Neuroprotective Agents

[+]

Isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.Nov 29, 2016

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Pubmed Data : J Agric Food Chem. 2016 Nov 30 ;64(47):9012-9021. Epub 2016 Nov 16. PMID: 27933873

Article Published Date : Nov 29, 2016

Study Type : Animal Study

Additional Links

Substances : Mangosteen

Diseases : Autoimmune Diseases, Multiple Sclerosis

Pharmacological Actions : Immunomodulatory: Th17 downregulation

[+]

Isogarcinol is a promising immunosuppressive agent for treating psoriasis.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 Feb 1 ;65(4):846-857. Epub 2017 Jan 24. PMID: 28081600

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Mangosteen

Diseases : Lipopolysaccharide-Induced Toxicity, Psoriasis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Immunosuppressive Agents, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-23 Downregulation, Interleukin-2 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Korean red ginseng extract alleviated neurological impairment of myelin oligodendrocyte glycoprotein induced mouse model of chronic experimental autoimmune encephalomyelitis.Apr 06, 2015

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Pubmed Data : Mol Neurobiol. 2015 Apr 7. Epub 2015 Apr 7. PMID: 25846819

Article Published Date : Apr 06, 2015

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean), Ginsenosides

Diseases : Autoimmune Diseases, Encephalomyelitis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Lactobacillus rhammosus GG might be an additional or supplementary therapy for allergic airway diseases.Mar 22, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Microbiol Immunol Infect. 2019 Mar 23. Epub 2019 Mar 23. PMID: 30952512

Article Published Date : Mar 22, 2019

Study Type : Animal Study

Additional Links

Substances : Lactobacillus rhamnosus GG

Diseases : Asthma

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Mangiferin may ameliorate colitis by the restoration of disturbed Th17/Treg cells and inhibition of macrophage activation.Apr 30, 2016

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Pubmed Data : Int Immunopharmacol. 2016 May ;34:220-8. Epub 2016 Mar 9. PMID: 26971225

Article Published Date : Apr 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Colitis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Oral administration of cinnamon powder may be beneficial in MS patients and that no other existing anti-MS therapies could be so economical and trouble free as this approach.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(1):e0116566. Epub 2015 Jan 8. PMID: 25569428

Article Published Date : Dec 31, 2014

Study Type : Transgenic Animal Study

Additional Links

Substances : Cinnamon

Diseases : Encephalomyelitis, Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation

Additional Keywords : Dose Response, Gene Expression Regulation

[+]

Oral berberine exerted anti-arthritic effect through inhibiting Th17 cell response.Jun 20, 2017

Click here to read the entire abstract

Pubmed Data : FEBS J. 2017 Jun 21. Epub 2017 Jun 21. PMID: 28636167

Article Published Date : Jun 20, 2017

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Arthritis

Pharmacological Actions : Immunomodulatory: Th17 downregulation

[+]

Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities.Jul 14, 2019

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Pubmed Data : Inflammopharmacology. 2019 Jul 15. Epub 2019 Jul 15. PMID: 31309485

Article Published Date : Jul 14, 2019

Study Type : Insect Study

Additional Links

Substances : Paeoniflorin

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Prophylactic effects of Lonicera japonica extract on dextran sulphate sodium-induced colitis.Jan 27, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Nutr. 2013 Jan 28 ;109(2):283-92. Epub 2012 May 9. PMID: 22569277

Article Published Date : Jan 27, 2013

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Red ginseng extracts can ameliorate arthritis in mice with CIA by targeting pathogenic Th17 and osteoclast differentiation, suggesting a novel therapy for treatment of RA.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2014 ;2014:351856. Epub 2014 Jul 23. PMID: 25147435

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean)

Diseases : Arthritis, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation

Additional Keywords : Plant Extracts

[+]

Resveratrol modulates the gut microbiota to prevent murine colitis development.Mar 20, 2019

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Pubmed Data : J Leukoc Biol. 2019 Mar 21. Epub 2019 Mar 21. PMID: 30897248

Article Published Date : Mar 20, 2019

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Colitis

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory: Th17 downregulation

[+]

Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.Feb 18, 2019

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Pubmed Data : Behav Brain Res. 2019 Feb 19 ;364:213-224. Epub 2019 Feb 19. PMID: 30790585

Article Published Date : Feb 18, 2019

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Autism

Pharmacological Actions : Antioxidants, Immunomodulatory: Th17 downregulation, Nrf2 activation

[+]

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.Jul 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2016 Aug ;14(2):1601-9. Epub 2016 Jun 23. PMID: 27357729

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-23 Downregulation

[+]

THC treatment during Delayed-type hypersensitivity response can simultaneously inhibit Th1/Th17 activation via regulation of microRNA expression.Mar 31, 2016

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Pubmed Data : J Mol Med (Berl). 2016 Apr 1. Epub 2016 Apr 1. PMID: 27038180

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Hypersensitivity

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, MicroRNA modulator

[+]

The consumption of phenolic and protein compounds extracted from flaxseeds has a protective effect on TNBS-induced colitis.Jun 21, 2018

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Pubmed Data : Mol Nutr Food Res. 2018 Jun 22:e1800088. Epub 2018 Jun 22. PMID: 29932491

Article Published Date : Jun 21, 2018

Study Type : Animal Study

Additional Links

Substances : Flaxseed

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation

[+]

The effect of Zataria multiflora on Th1/Th2 and Th17/T regulatory in a mouse model of allergic asthma.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2017 ;8:458. Epub 2017 Aug 7. PMID: 28824424

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Zataria multiflora

Diseases : Asthma

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-4 downregulation

[+]

These obtained results suggest that P. nigrum fruit extract has the promising strategy for immunotherapy in allergic rhinitis disease.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1915-1923. Epub 2018 Nov 26. PMID: 30551446

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, STAT3 Inhibitor

[+]

These results provide insights into butyrate as a potential therapeutic for the treatment of inflammatory bowel disease.Mar 26, 2019

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Pubmed Data : Inflamm Bowel Dis. 2019 Mar 27. Epub 2019 Mar 27. PMID: 30918945

Article Published Date : Mar 26, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Butyrate

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-10 upregulation

[+]

These results suggest that vinegar supplementation might provide a new dietary strategy for the prevention of ulcerative colitis.Feb 09, 2016

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2016 Feb 10 ;64(5):1111-21. Epub 2016 Feb 1. PMID: 26795553

Article Published Date : Feb 09, 2016

Study Type : Animal Study

Additional Links

Substances : Acetic Acid, Vinegar

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

These results support the use of CoQ10 as a potential targeted therapy for the treatment of colitis.Aug 31, 2017

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Pubmed Data : J Med Food. 2017 Sep ;20(9):821-829. Epub 2017 Aug 17. PMID: 28816577

Article Published Date : Aug 31, 2017

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, STAT3 Inhibitor

[+]

This data suggests that CBD exerts its immunoregulatory effects via induction of CD4(+)CD25(-)CD69(+)LAG3(+) cells.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neuroinflammation. 2015 ;12:52. Epub 2015 Mar 15. PMID: 25880134

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Total glucosides of peony could be a potential therapeutic agent for multiple sclerosis.Jul 14, 2015

Click here to read the entire abstract

Pubmed Data : J Neuroimmunol. 2015 Jul 15 ;284:67-73. Epub 2015 May 12. PMID: 26025060

Article Published Date : Jul 14, 2015

Study Type : Animal Study

Additional Links

Substances : Peony

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

Additional Keywords : Phytotherapy

[+]

Vitamin D down-regulates the expression of inflammatory cytokines, chemokines and chemokine receptors in experimental autoimmune encephalomyelitis.Feb 14, 2018

Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2018 Feb 15:1-13. Epub 2018 Feb 15. PMID: 29447086

Article Published Date : Feb 14, 2018

Study Type : Animal Study

Additional Links

Substances : Vitamin D

Diseases : Encephalomyelitis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-23 Downregulation

[+]

A novel probiotic mixture, slows down the tumor growth significantly and reduces the tumor size and weight by 40% compared with the control.Feb 15, 2016

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Pubmed Data : Proc Natl Acad Sci U S A. 2016 Feb 16. Epub 2016 Feb 16. PMID: 26884164

Article Published Date : Feb 15, 2016

Study Type : In Vitro Study

Additional Links

Substances : Probiotics

Diseases : Gastrointestinal Inflammation, Liver Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-17 downregulation

Additional Keywords : Microbiota

[+]

A review of the immunomodulatory role of vitamin D.Aug 25, 2018

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Pubmed Data : Adv Exp Med Biol. 2018 Aug 26. Epub 2018 Aug 26. PMID: 30143987

Article Published Date : Aug 25, 2018

Study Type : Review

Additional Links

Substances : Vitamin D

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Astragaloside could be used for the treatment of multiple sclerosis and other similar autoimmune diseases.Oct 28, 2018

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Pubmed Data : Toxicol Appl Pharmacol. 2018 Oct 29 ;362:105-115. Epub 2018 Oct 29. PMID: 30385269

Article Published Date : Oct 28, 2018

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Autoimmune Diseases, Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Betulinic acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation.Jul 31, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Aug ;73:343-352. Epub 2019 May 23. PMID: 31129421

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as multiple sclerosis.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2018 ;9:1807. Epub 2018 Aug 13. PMID: 30150982

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Carnosol

Diseases : Autoimmune Diseases, Encephalomyelitis, Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Curcumin can modulate Th17/Treg balance specifically on CD4+ T cells of SLE patients without affecting healthy subjects.Dec 31, 2015

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Pubmed Data : Cent Eur J Immunol. 2016 ;40(4):461-9. Epub 2016 Jan 15. PMID: 26862311

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Immunomodulatory: Th17 downregulation

[+]

HS-23, a Lonicera japonica extract, reverses sepsis-induced immunosuppression by inhibiting lymphocyte apoptosis.Aug 01, 2015

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Pubmed Data : J Ethnopharmacol. 2015 Aug 2 ;171:231-9. Epub 2015 Jun 9. PMID: 26068428

Article Published Date : Aug 01, 2015

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Sepsis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Panax notoginseng saponin controls IL-17 expression in helper T cells.Dec 31, 2016

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Pubmed Data : J Ocul Pharmacol Ther. 2017 05 ;33(4):285-289. Epub 2017 Jan 4. PMID: 28051353

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Panax Notoginseng

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation

[+]

Resveratrol has immunomodulatory activity that may be useful for autoimmune conditions such as MS. Mar 01, 2011

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2011 Mar;11(3):310-8. Epub 2010 Aug 12. PMID: 20708723

Article Published Date : Mar 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Autoimmune Diseases, Multiple Sclerosis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Immunosuppressive Agents

[+]

This study explains the beneficial role of CBD in pathological memory T cells and in autoimmune diseases.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neuroinflammation. 2016 ;13(1):136. Epub 2016 Jun 3. PMID: 27256343

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Autoimmune Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Immunomodulatory: Th17 downregulation, Nrf2 activation

[+]

This study identified that arctigenin is a selective ERβ agonist.Dec 19, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Dec 20 ;7(51):83893-83906. PMID: 27863380

Article Published Date : Dec 19, 2016

Study Type : In Vitro Study

Additional Links

Substances : Arctigenin

Diseases : Colitis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Thymol as a reciprocal regulator of T cell differentiation: Promotion of regulatory T cells and suppression of Th1/Th17 cells.Jan 31, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Feb ;67:417-426. Epub 2018 Dec 31. PMID: 30586665

Article Published Date : Jan 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Thymol

Diseases : Immune Dysregulation: TH17 over-expression, Immune Dysregulation: TH1 dominance

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

[+]

Z. multiflora showed anti-inflammatory, antioxidant, and immunomodulatory effects.Jan 31, 2018

Click here to read the entire abstract

Pubmed Data : Fundam Clin Pharmacol. 2018 Feb ;32(1):26-50. PMID: 29125648

Article Published Date : Jan 31, 2018

Study Type : Review

Additional Links

Substances : Zataria multiflora

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-4 downregulation

Additional Keywords : Phytotherapy, Plant Extracts

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Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis.Oct 12, 2017

Oral administration of Zataria multiflora extract decreases IL-17 expression in perennial allergic rhinitis.Mar 31, 2018

These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis.Sep 14, 2019

Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance.Apr 30, 2011

Arctigenin ameliorates colitis through down-regulating the differentiation of Th1 and Th17 cells via mTORC1 pathway. Aug 14, 2015

Arctigenin may have anti-inflammatory and immunosuppressive properties via inhibiting Th17 cells.Oct 05, 2015

Astragalus polysaccharide exerts an effective therapeutic effect against experimental colitis by recovering the functional status of Treg cells.Mar 20, 2016

Autism is associated with dysregulation of transcription factor signalling that can be corrected by resveratrol treatment in mice. Aug 29, 2016

Berberine has anti-inflammatory effects on H. pylori-induced chronic gastritis.Jan 17, 2018

Berberine prevents ulcerative colitis by modifying gut microbiota and regulating the balance of Treg/Th17.Dec 31, 2017

Cucurbitacin E ameliorates acute graft-versus-host disease.Sep 17, 2018

Docosahexaenoic acid Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis suppresses experimental autoimmune encephalomyelitis.Sep 18, 2010

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

Flos Abelmoschus manihot extract attenuates DSS-induced colitis by regulating gut microbiota and Th17/Treg balance.Aug 31, 2019

Gallic acid may be used as a therapeutic agent for allergic rhinitis.Mar 14, 2019

Hydrogen rich water may have great potential in the treatment of Multiple sclerosis.May 14, 2016

Isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.Nov 29, 2016

Isogarcinol is a promising immunosuppressive agent for treating psoriasis.Jan 31, 2017

Korean red ginseng extract alleviated neurological impairment of myelin oligodendrocyte glycoprotein induced mouse model of chronic experimental autoimmune encephalomyelitis.Apr 06, 2015

Lactobacillus rhammosus GG might be an additional or supplementary therapy for allergic airway diseases.Mar 22, 2019

Mangiferin may ameliorate colitis by the restoration of disturbed Th17/Treg cells and inhibition of macrophage activation.Apr 30, 2016

Oral administration of cinnamon powder may be beneficial in MS patients and that no other existing anti-MS therapies could be so economical and trouble free as this approach.Dec 31, 2014

Oral berberine exerted anti-arthritic effect through inhibiting Th17 cell response.Jun 20, 2017

Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities.Jul 14, 2019

Prophylactic effects of Lonicera japonica extract on dextran sulphate sodium-induced colitis.Jan 27, 2013

Red ginseng extracts can ameliorate arthritis in mice with CIA by targeting pathogenic Th17 and osteoclast differentiation, suggesting a novel therapy for treatment of RA.Dec 31, 2013

Resveratrol modulates the gut microbiota to prevent murine colitis development.Mar 20, 2019

Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.Feb 18, 2019

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.Jul 31, 2016

THC treatment during Delayed-type hypersensitivity response can simultaneously inhibit Th1/Th17 activation via regulation of microRNA expression.Mar 31, 2016

The consumption of phenolic and protein compounds extracted from flaxseeds has a protective effect on TNBS-induced colitis.Jun 21, 2018

The effect of Zataria multiflora on Th1/Th2 and Th17/T regulatory in a mouse model of allergic asthma.Dec 31, 2016

These obtained results suggest that P. nigrum fruit extract has the promising strategy for immunotherapy in allergic rhinitis disease.Dec 31, 2018

These results provide insights into butyrate as a potential therapeutic for the treatment of inflammatory bowel disease.Mar 26, 2019

These results suggest that vinegar supplementation might provide a new dietary strategy for the prevention of ulcerative colitis.Feb 09, 2016

These results support the use of CoQ10 as a potential targeted therapy for the treatment of colitis.Aug 31, 2017

This data suggests that CBD exerts its immunoregulatory effects via induction of CD4(+)CD25(-)CD69(+)LAG3(+) cells.Dec 31, 2014

Total glucosides of peony could be a potential therapeutic agent for multiple sclerosis.Jul 14, 2015

Vitamin D down-regulates the expression of inflammatory cytokines, chemokines and chemokine receptors in experimental autoimmune encephalomyelitis.Feb 14, 2018

A novel probiotic mixture, slows down the tumor growth significantly and reduces the tumor size and weight by 40% compared with the control.Feb 15, 2016

A review of the immunomodulatory role of vitamin D.Aug 25, 2018

Astragaloside could be used for the treatment of multiple sclerosis and other similar autoimmune diseases.Oct 28, 2018

Betulinic acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation.Jul 31, 2019

Carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as multiple sclerosis.Dec 31, 2017

Curcumin can modulate Th17/Treg balance specifically on CD4+ T cells of SLE patients without affecting healthy subjects.Dec 31, 2015

HS-23, a Lonicera japonica extract, reverses sepsis-induced immunosuppression by inhibiting lymphocyte apoptosis.Aug 01, 2015

Panax notoginseng saponin controls IL-17 expression in helper T cells.Dec 31, 2016

Resveratrol has immunomodulatory activity that may be useful for autoimmune conditions such as MS. Mar 01, 2011

This study explains the beneficial role of CBD in pathological memory T cells and in autoimmune diseases.Dec 31, 2015

This study identified that arctigenin is a selective ERβ agonist.Dec 19, 2016

Thymol as a reciprocal regulator of T cell differentiation: Promotion of regulatory T cells and suppression of Th1/Th17 cells.Jan 31, 2019

Z. multiflora showed anti-inflammatory, antioxidant, and immunomodulatory effects.Jan 31, 2018

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Immunomodulatory: Th17 downregulation

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52 Abstracts with Immunomodulatory: Th17 downregulation Research