Insulin Sensitizers

Name	AC	CK
Vitamin D	8	90
Magnesium	5	60
Spirulina	3	32
Arginine	3	30
Ginger	5	26
Nuts	1	20
Omega-3 Fatty Acids	2	20
Polyphenols	2	20
Cinnamon	4	16
Nigella sativa (aka Black Seed)	4	16
Chlorella (Algae)	2	12
Melatonin	2	12
Probiotics	2	12
Almond	1	10
Banaba	1	10
Berries: All	1	10
Bifidobacterium Bifidum	1	10
Chlorogenic Acid	1	10
Coconut Oil	1	10
Cranberry	1	10
Fruit: All	1	10
Lactobacillus Acidophilus	1	10
Lactobacillus casei	1	10
Lemon	1	10
Lemon Juice	1	10
NAC (N-acetyl-L-cysteine)	1	10
Olive Oil	1	10
Olive leaf extract	1	10
Orange	1	10
Passion fruit	1	10
Pomegranate	1	10
Resistant Starch	1	10
Strawberry	1	10
Vegetables: All	1	10
Vitamin B-3 (Niacin)	1	10
Vitamin C	1	10
Vitamin K	1	10
Walnut	1	10
Whey	1	10
beta-Carotene	1	10
Curcumin	5	9
Coenzyme Q10	2	7
Astaxanthin	3	6
Berberine	2	6
Marjoram	1	5
Cinnamaldehyde	2	4
Gallic Acid	2	4
Bitter Melon	2	3
Jambul	2	3
Naringenin	2	3
Puerarin	2	3
Apple Polyphenols	1	2
Betulinic acid	1	2
Blackberry	1	2
Citrus Pectin	1	2
Coffee: Decaffeinated	1	2
Coffee: Green/Unroasted	1	2
Cucurbitacin E	1	2
D-Chiro-Inositol	1	2
DHA (Docosahexaenoic Acid)	1	2
Docosapentaenoic Acid	1	2
False Black Pepper	1	2
Fig	1	2
Fish Oil	1	2
Garlic	1	2
Genistein	1	2
Gingerol	1	2
Grape Seed Extract	1	2
Honokiol	1	2
Indian Gooseberry	1	2
Krill	1	2
Litchi	1	2
Lycopene	1	2
Miracle Fruit	1	2
Moringa oleifera	1	2
Myricetin	1	2
Nettle	1	2
Onion	1	2
Panax Notoginseng	1	2
Passion Flower	1	2
Phloretin	1	2
Pineapple	1	2
Pomegranate Peel	1	2
Pomegranate Seed	1	2
Pomegranate flower	1	2
Prickly Pear Cactus	1	2
Quercetin	1	2
Rooibos	1	2
Rose	1	2
Royal Jelly	1	2
Sage	1	2
Tarragon	1	2
Trigonelline	1	2
Urolithin A	1	2
White Mulberry	1	2
Zataria multiflora	1	2
Alpha-Lipoic Acid	1	1
Argania spinosa (Argan)	1	1
Camel Milk	1	1
Dihydrocurcumin	1	1
Ginsenosides	1	1
Glyceollins	1	1
Hydroxytyrosol	1	1
Phytoalexins	1	1
Resveratrol	1	1
Rosemaric Acid	1	1
Saffron	1	1
Soy	1	1
Stilbenes	1	1
Tangeretin	1	1
Theaflavins	1	1
Turmeric	1	1

Therapeutic Actions : Exercise: Aerobic

Pharmacological Actions : Insulin Sensitizers

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Berries reduce postprandial insulin responses to wheat and rye breads in healthy women.Mar 31, 2013

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Pubmed Data : J Nutr. 2013 Apr ;143(4):430-6. Epub 2013 Jan 30. PMID: 23365108

Article Published Date : Mar 31, 2013

Study Type : Human Study

Additional Links

Substances : Berries: All

Diseases : Hyperinsulinism, Insulin: Elevated, Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

Problem Substances : Rye, Wheat

Adverse Pharmacological Actions : Insulinotropic

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Black cumin seeds have significant anti-diabetic effects in type 2 diabetics. Oct 01, 2010

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Pubmed Data : Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):344-54. PMID: 21675032

Higher magnesium intake is independently associated with better insulin sensitivity in patients at risk for type 2 diabetes mellitus.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Rev Invest Clin. 2017 Jan-Feb;69(1):40-46. PMID: 28239181

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

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Hyperbaric oxygen therapy used in this study may be effective for diabetes patients with acute stroke.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Res. 2015 May ;35(5):409-20. Epub 2015 Apr 10. PMID: 25912765

Article Published Date : Apr 30, 2015

Pubmed Data : J Obstet Gynaecol India. 2019 Feb ;69(1):77-81. Epub 2018 May 28. PMID: 30814814

Article Published Date : Jan 31, 2019

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2009 Apr 21;15(15):1809-15. PMID: 19370776

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Pubmed Data : Nutrients. 2011 Jul ;3(7):712-24. Epub 2011 Jul 18. PMID: 22254118

Article Published Date : Jul 01, 2011

Study Type : Human Study

Additional Links

Substances : Spirulina

Diseases : HIV Infections, Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

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Supplementation with fruit and vegetable juice concentrate was associated with an increase in serum β-carotene concentrations, reduction in adiposity and an improvement in insulin resistance.Jun 30, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pediatr. 2012 Jul ;161(1):58-64.e1-2. Epub 2012 Feb 28. PMID: 22381025

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Lab Physicians. 2015 Jul-Dec;7(2):75-8. PMID: 26417155

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 May 27 ;11(5). Epub 2019 May 27. PMID: 31137828

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Pubmed Data : Biomed Pharmacother. 2017 Jan 13 ;88:52-60. Epub 2017 Jan 13. PMID: 28092845

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(6):e0178910. Epub 2017 Jun 9. PMID: 28598969

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Cucurbitacin E

Diseases : Hyperglycemia, Insulin Resistance, Metabolic Syndrome X, Obesity

Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers

Additional Keywords : Anti-Obesity Agents

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Curcumin administration improved insulin sensitivity and reduced hepatic gluconeogenic gene expression.Sep 01, 2015

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Pubmed Data : J Nutr. 2015 Sep 2. Epub 2015 Sep 2. PMID: 26338887

Embelia ribes extract reduces high fat diet and low dose streptozotocin-induced diabetic nephrotoxicity in rats.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : EXCLI J. 2013 ;12:858-71. Epub 2013 Sep 24. PMID: 26622220

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : False Black Pepper

Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy, Lipid Peroxidation

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Insulin Sensitizers, Renoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

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Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice.Aug 04, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Metab (Lond). 2011 ;8:53. Epub 2011 Jul 27. PMID: 21794123

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Article Publish Status : This is a free article. Click here to read the complete article.

Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat.Sep 30, 2004

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Pubmed Data : J Ethnopharmacol. 2004 Oct ;94(2-3):251-9. PMID: 15325727

Article Published Date : Sep 30, 2004

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Hyperlipidemia, Insulin Resistance

Pharmacological Actions : Hypolipidemic, Insulin Sensitizers

Additional Keywords : Plant Extracts

Problem Substances : Insulin

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Nigella sativa oil and chromium picolinate monotherapy can reduce fructose-induced insulin resistance.Oct 03, 2017

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2017 Oct 4. Epub 2017 Oct 4. PMID: 28975521

Article Published Date : Oct 03, 2017

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : High Fructose Diet, Hyperinsulinism

Pharmacological Actions : Insulin Sensitizers

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O. humifusa supplementation might play an important role for improving insulin sensitivity in rat skeletal muscle.Mar 27, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2013 Mar 28 ;14(4):7140-54. Epub 2013 Mar 28. PMID: 23538842

Article Published Date : Mar 27, 2013

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

Additional Keywords : Plant Extracts

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Ocimum kilimandscharicum L. restores ovarian functions in letrozole-induced polycystic ovary syndrome.Jul 07, 2019

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Pubmed Data : Life Sci. 2019 Jul 8:116640. Epub 2019 Jul 8. PMID: 31295470

Click here to read the entire abstract

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2006 Aug;143(4):429-35. Epub 2006 Apr 28. PMID: 16753349

Article Publish Status : This is a free article. Click here to read the complete article.

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Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells.Jun 30, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1327-1336. Epub 2018 May 7. PMID: 29864915

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Dihydrocurcumin

Diseases : Inflammation, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Insulin Sensitizers

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DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake.Jun 30, 2018

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Pubmed Data : Obesity (Silver Spring). 2018 Jul ;26(7):1153-1160. Epub 2018 May 3. PMID: 29722480

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Insulin Resistance

Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers

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Ginsenosides enhance insulin-stimulated glucose uptake and homeostasis. Nov 01, 2008

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View the Evidence: 148 Abstracts with Insulin Sensitizers Research

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A systematic review and meta-analysis of the role of acupuncture in the treatment of insulin resistance.Aug 04, 2019

Magnesium supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes.Aug 16, 2016

Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension.Apr 30, 2017

These results suggest that nut consumption may improve insulin sensitivity.Jan 31, 2019

Vitamin D supplementation helps to control glycemic response and improve insulin sensitivity in type 2 diabetic patients.Aug 31, 2017

L-arginine augments the effects of exercise training on insulin sensitivity and capillary growth in muscles.Jan 01, 2007

3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes.Feb 09, 2015

A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents.Jan 31, 2010

A single-loading dose of intravenous magnesium improved insulin resistance indices in critically ill patients with stress-induced hyperglycemia.Dec 31, 2017

Aerobic exercise increases peripheral and hepatic insulin sensitivity in sedentary adolescents.Oct 31, 2009

Berries reduce postprandial insulin responses to wheat and rye breads in healthy women.Mar 31, 2013

Black cumin seeds have significant anti-diabetic effects in type 2 diabetics. Oct 01, 2010

Brief intense interval exercise improved indices of cardiometabolic health to the same extent as traditional endurance training in sedentary men.Dec 31, 2015

Chlorella vulgaris supplementation have therapeutic value in patients with non-alcoholic fatty liver disease.Oct 31, 2012

Chlorogenic acid increased insulin sensitivity and improved both anthropometric evaluations and the lipid profile.Dec 19, 2017

Coconut oil consumption improves fat-free mass, plasma HDL-cholesterol and insulin sensitivity.Dec 28, 2018

Correction of vitamin D deficiency leads to increased insulin sensitivity that was significantly able to maintain glucose in the normal range.Jan 13, 2016

DLBS3233 treatment once daily was promisingly efficacious in improving insulin sensitivity and preserving the performance of β-cells.Dec 31, 2015

Exercise overcomes skeletal muscle insulin resistance. Aug 01, 2011

Ginger has a beneficial effect on type 2 diabetics.Mar 17, 2013

High-dose vitamin D supplementation significantly improved insulin resistance in pregnant women with GDM.Aug 31, 2016

Higher magnesium intake is independently associated with better insulin sensitivity in patients at risk for type 2 diabetes mellitus.Dec 31, 2016

Hyperbaric oxygen therapy used in this study may be effective for diabetes patients with acute stroke.Dec 31, 2016

in the form of a new beverage can improve insulin resistance, insulin, testosterone level, BMI, weight and waist circumference in PCOS. Dec 31, 2018

Insulin sensitivity improvement with exercise training is mediated by body weight loss in subjects with metabolic syndrome.May 30, 2019

Lemon detox program reduces body fat and insulin resistance through caloric restriction and might have a potential beneficial effect on risk factors for cardiovascular diseaseApr 30, 2015

Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients.May 01, 2001

Long-term oral L-arginine treatment has a beneficial effect when added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients.Nov 01, 2006

Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease.Dec 11, 2017

NAC can be used as a substitute for insulin-sensitizing agent in treatment of polycystic ovarian syndrome.Jan 31, 2019

Niacin action in the atherogenic mixed dyslipidemia of metabolic syndrome.Mar 28, 2018

Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men.Dec 31, 2012

Olive oil consumption has an ameliorative effect in non-alcoholic fatty liver disease.Apr 21, 2009

Oral magnesium supplementation decreases high sensitivity C-reactive protein levels in subjects with prediabetes and hypomagnesemia.Apr 30, 2014

Polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects.Jan 31, 2017

Resistant starch from high-amylose maize increases insulin sensitivity in overweight and obese men.Mar 31, 2012

Spirulina improves insulin resistance in 100% of patients tested. Jul 01, 2011

Supplementation with fruit and vegetable juice concentrate was associated with an increase in serum β-carotene concentrations, reduction in adiposity and an improvement in insulin resistance.Jun 30, 2012

Synbiotic supplementation in diabetic patients with coronary heart disease had beneficial effects on insulin metabolism and HDL-cholesterol levels.Dec 31, 2016

The study concluded that there was a beneficial effect of vitamin D supplementation on ovulatory dysfunctions and blood pressure.Sep 30, 2017

These results suggested that a daily consumption of orange had a positive effect on the intestinal microbiota and metabolic biomarkers of young women.Jan 31, 2019

This study showed a lower serum magnesium level in diabetic patients compared to control. Jun 30, 2015

Vitamin C ameliorates skeletal muscle oxidative stress and improves insulin-mediated glucose disposal in people with type 2 diabetes.Jan 12, 2016

Vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among gestational diabetes patients had beneficial effects.Mar 31, 2017

Vitamin D supplementation for 1 year effectively improves fasting glucose level and insulin resistance in healthy Japanese adults.Sep 30, 2016

Vitamin D supplementation had beneficial effects in diabetic diabetic hemodialysis patients.Sep 27, 2017

Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose.Nov 01, 2011

Vitamin K1 supplementation for 4 weeks in prediabetic and premenopause women had beneficial effects on glycemic status and insulin sensitivity.Jul 31, 2015

Walnuts and almonds may improve metabolic and endocrine parameters in PCOS.Mar 01, 2011

Whey proteins improve fasting lipids and insulin levels in overweight and obese individuals.Sep 01, 2010

Yellow passion fruit peel flour supplementation decreased insulin resistance in type 2 diabetic patients.Oct 21, 2012

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

The present study show the beneficial effects of marjoram tea on the hormonal profile of polycystic ovary syndrome.Jan 31, 2016

These data suggest that mitochondrial CoQ is a proximal driver of mitochondrial oxidants and insulin resistance.Feb 05, 2018

These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.Mar 07, 2012

"6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice."Jan 10, 2012

"Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats."Oct 31, 2012

13 weeks of swim training could reverse HFD-induced metabolic disorders including insulin resistance and inflammation.Dec 31, 2016

A Panax notoginseng root extract is a promising agent for controlling hyperglycemia by enhancing glucose uptake in skeletal muscle.Oct 23, 2016

Antidiabetic potential of gallic acid from Emblica officinalis.Mar 31, 2019

Apple polyphenol extracts might emerge as a promising nutritional ingredient in the management of chronic diseases such as diabetes.Dec 31, 2015

Aspalathin-enriched green rooibos extract reduces hepatic insulin resistance.Jan 31, 2019

Astaxanthin prevents fructose-induced adverse changes in insulin signaling and inflammation in obese rats.Nov 17, 2011

Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice.Oct 31, 2012

Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome.Oct 04, 2018

Black cumin may have antidiabetic effects by increasing insulin sensitivity. Jan 01, 2011

Blackberry extract given to rats decreased glycemia and increased insulin sensitivity.May 31, 2015

Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats.Jan 12, 2017

Cinnamaldehyde protects from the hypertension associated with type 1 and type 2 diabetes.Aug 05, 2011

Cinnamon reduces insulin resistance in an animal model. May 05, 2011

Cucurbitacin E reduces obesity and related metabolic dysfunction in mice.Dec 31, 2016

Curcumin administration improved insulin sensitivity and reduced hepatic gluconeogenic gene expression.Sep 01, 2015

Insulin Sensitizers

View the Evidence:
148 Abstracts with Insulin Sensitizers Research