MicroRNA modulator

Name	AC	CK
Curcumin	27	39
EGCG (Epigallocatechin gallate)	18	27
Polyphenols	10	23
Berberine	9	16
Flavonoids	2	12
Quercetin	7	11
Vitamin C	2	11
Chlorella (Algae)	1	10
Chocolate	1	10
Resveratrol	5	8
Sulforaphane	7	7
Oridonin	2	6
Pterostilbene	3	6
Genistein	4	5
Silymarin	1	5
Spirulina	1	5
Apigenin	3	4
Delta-tetrahydrocannabinol (THC)	2	4
Grape	2	4
Silibinin	3	4
Blueberry	2	3
Catechin	3	3
Cucurbitacin E	2	3
Emodin	2	3
Ginseng (Korean)	2	3
Honokiol	2	3
Indole-3-Carbinol	2	3
Melatonin	2	3
Reishi Mushroom	2	3
Selenium	2	3
Tocotrienol: Delta	2	3
Ursolic Acid	2	3
Vitamin D	3	3
Xanthohumol	2	3
Achiote	1	2
Amla Fruit	1	2
Boswellia	1	2
Cannabis	1	2
Carnosic Acid	1	2
Chokeberry	1	2
Citrus naringin	1	2
Fish Oil	1	2
Ginsenosides	1	2
Glycyrrhizin	1	2
Jambul	1	2
Kaempferol	1	2
Magnolia	1	2
Mango	1	2
Moringa oleifera	1	2
Naringenin	1	2
Nigella sativa (aka Black Seed)	1	2
Nobiletin	2	2
Potato: Pigmented	1	2
Prunella vulgaris.	1	2
Sweet Potato: Purple	1	2
Tangeretin	1	2
Thymoquinone	1	2
Tripterygium wilfordii	1	2
Triptolide	1	2
Turmeric	1	2
Vitamin E: Gamma-tocotrienol	1	2
Walnut	1	2
beta-Carotene	1	2
6-Shogaol	1	1
Aloe Vera	1	1
Arctigenin	1	1
Camel Milk	1	1
Cruciferous Vegetables	1	1
Fiber	1	1
Folate	1	1
Folic Acid	1	1
Garcinia indica	1	1
Green Tea	1	1
Huaier (Trametes robiniophila murr)	1	1
Isoflavones	1	1
Isothiocyanates	1	1
Legumes	1	1
Licorice	1	1
Mangiferin	1	1
Mistletoe	1	1
Olive leaf extract	1	1
Phenethyl isothiocyanate	1	1
Phospholipids	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Pomegranate Peel	1	1
Pomegranate Polyphenols	1	1
Puerarin	1	1
Tannic Acid	1	1
Vitamin A	1	1
Vitamin E	1	1

[+]

Blueberry phenolics reduce gastrointestinal infection of patients with cerebral venous thrombosis.Dec 31, 2016

[+]

Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells.Dec 27, 2018

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Pubmed Data : Transl Oncol. 2018 Dec 28 ;12(3):513-522. Epub 2018 Dec 28. PMID: 30597288

Article Published Date : Dec 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Chemotherapeutic, MicroRNA modulator

Additional Keywords : Exosomes

[+]

Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression.Jan 23, 2017

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Cell cycle regulation by berberine in human melanoma A375 cells.Jul 31, 2020

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Pubmed Data : Bull Exp Biol Med. 2020 Aug ;169(4):491-496. Epub 2020 Sep 11. PMID: 32915362

Article Published Date : Jul 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, MicroRNA modulator

[+]

Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells.Apr 23, 2019

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Pubmed Data : Biosci Biotechnol Biochem. 2019 Apr 24:1-9. Epub 2019 Apr 24. PMID: 31017523

Article Published Date : Apr 23, 2019

Study Type : In Vitro Study

Additional Links

Substances : Citrus Peel , Flavonoids, Hesperidin, Nobiletin , Tangeretin

Pharmacological Actions : Hypolipidemic, MicroRNA modulator

[+]

Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration.Jul 19, 2017

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Pubmed Data : Sci Rep. 2017 Jul 20 ;7(1):6015. Epub 2017 Jul 20. PMID: 28729651

Article Published Date : Jul 19, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Retinal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, MicroRNA modulator

[+]

Combined curcumin and temozolomide treatment significantly inhibited U 87 MG cell proliferation and induced apoptotic death, compared with each alone.Jul 16, 2015

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Pubmed Data : Mol Med Rep. 2015 Jul 17. Epub 2015 Jul 17. PMID: 26239619

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Pubmed Data : Rev Physiol Biochem Pharmacol. 2016 Jul 23. Epub 2016 Jul 23. PMID: 27457236

Article Published Date : Jul 22, 2016

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Cancers: All

Pharmacological Actions : MicroRNA modulator

[+]

Curcumin could increase the expression of hsa-miR-138, hsa-miR-138 inhibited cell proliferation and invasive ability.Dec 31, 2014

Pubmed Data : Tumour Biol. 2017 Feb ;39(2):1010428317691680. PMID: 28222667

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Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

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Pubmed Data : Adv Nutr. 2011 Nov ;2(6):472-85. Epub 2011 Nov 3. PMID: 22332090

Article Published Date : Oct 31, 2011

Study Type : Review

Additional Links

Substances : Curcumin, EGCG (Epigallocatechin gallate), Fiber, Folate, Genistein, Resveratrol, Selenium, Vitamin A, Vitamin D, Vitamin E

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, MicroRNA modulator

Additional Keywords : Dietary Concentrations, Plant Extracts

[+]

DNC potentially can induce DNA hypomethylation and re-expression of silenced tumor suppressor genes in HCC.Sep 14, 2015

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Pubmed Data : Phytomedicine. 2015 Sep 15 ;22(10):961-7. Epub 2015 Jul 14. PMID: 26321746

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Pubmed Data : Surgery. 2015 Jul 17. Epub 2015 Jul 17. PMID: 26189955

Article Published Date : Jul 16, 2015

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Liver Cancer, Liver Cancer: Metastatic

Pharmacological Actions : Anti-metastatic, MicroRNA modulator

[+]

EGCG exerts anti-melanoma activity in a 67LR-dependent manner.Dec 31, 2015

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Pubmed Data : PLoS One. 2016 ;11(12):e0167435. Epub 2016 Dec 9. PMID: 27935974

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator

[+]

EGCG significantly inhibits HPV11 oncogenes expression in vitro. May 08, 2016

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Pubmed Data : Ann N Y Acad Sci. 2019 Sep 8. Epub 2019 Sep 8. PMID: 31495936

Article Published Date : Sep 07, 2019

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator

[+]

Galangin inhibits cholangiocarcinoma cell growth and metastasis.Dec 31, 2019

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Pubmed Data : Biomed Res Int. 2020 ;2020:5846938. Epub 2020 Jun 11. PMID: 32626749

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Cholangiocarcinoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator

[+]

Ganoderma lucidum could be a potential cardioprotective agent.Dec 31, 2015

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Pubmed Data : Oncoscience. 2016 ;3(7-8):203-207. Epub 2016 Aug 28. PMID: 27713910

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Cardiovascular Diseases

Pharmacological Actions : Cardioprotective, MicroRNA modulator

Additional Keywords : Risk Reduction

[+]

Garcinol has the potential as an antagonist against pancreatic cancer stem-like cells.Sep 23, 2015

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Pubmed Data : Biotechnol Appl Biochem. 2015 Sep 24. Epub 2015 Sep 24. PMID: 26400206

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Pubmed Data : Taiwan J Obstet Gynecol. 2020 May ;59(3):403-408. PMID: 32416888

Article Published Date : Apr 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Cervical Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator

Additional Keywords : Dose Response

[+]

Genistein inhibits A549 human lung cancer cell proliferation.Aug 31, 2016

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Pubmed Data : J Ginseng Res. 2019 Oct ;43(4):625-634. Epub 2019 Feb 28. PMID: 31700260

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

[+]

Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway.Oct 15, 2019

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Pubmed Data : Biomed Pharmacother. 2019 Oct 16 ;120:109483. Epub 2019 Oct 16. PMID: 31629252

Article Published Date : Oct 15, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Non-Small-Cell Lung Carcinoma

Pharmacological Actions : Antiproliferative , MicroRNA modulator

[+]

Ginsenoside Rh2 exerts anti-metastasis activity in hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491.Jul 03, 2019

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Pubmed Data : Anticancer Agents Med Chem. 2019 Jul 4. Epub 2019 Jul 4. PMID: 31272362

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:624132. Epub 2015 Oct 12. PMID: 26579204

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Pubmed Data : Front Oncol. 2014 ;4:227. Epub 2014 Aug 25. PMID: 25202679

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Melanoma, Melanoma: Metastatic

Pharmacological Actions : Anti-metastatic, Apoptotic, Cell cycle arrest, MicroRNA modulator

Additional Keywords : DNA Methyltransferase, Epigenetic Modification

[+]

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Pubmed Data : Cancer Cell Int. 2015 ;15:96. Epub 2015 Oct 9. PMID: 26457069

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Chemosensitizer, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Cancer Stem Cells

[+]

In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis.Apr 30, 2015

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Pubmed Data : Curr Pharmacol Rep. 2015 May ;1(3):179-196. Epub 2015 Jan 30. PMID: 26457242

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Pubmed Data : Front Pharmacol. 2018 ;9:837. Epub 2018 Jul 31. PMID: 30108506

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Licorice

Diseases : Lung Cancer

Pharmacological Actions : Antioxidants, Apoptotic, MicroRNA modulator, Nrf2 activation

[+]

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Pubmed Data : Front Pharmacol. 2020 ;11:137. Epub 2020 Mar 5. PMID: 32210798

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Lipopolysaccharide-Induced Toxicity, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor

[+]

Melatonin and pterostilbene is a potent strategy for colorectal cancer therapy.Oct 28, 2019

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Pubmed Data : Cancers (Basel). 2019 Oct 29 ;11(11). Epub 2019 Oct 29. PMID: 31671847

Article Published Date : Oct 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Melatonin, Pterostilbene

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, MicroRNA modulator

Additional Keywords : Natural Substance Synergy

[+]

Melatonin inhibits the progression of hepatocellular carcinoma.Sep 09, 2018

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Pubmed Data : Biomed Res Int. 2020 ;2020:1621394. Epub 2020 Nov 24. PMID: 33299858

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator

Additional Keywords : Exosomes

[+]

Melittin-induced long non-coding RNA NONHSAT105177 inhibits proliferation and migration of pancreatic ductal adenocarcinoma.Jan 19, 2018

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Pubmed Data : Cell Death Dis. 2018 09 20 ;9(10):940. Epub 2018 Sep 20. PMID: 30237397

Article Published Date : Jan 19, 2018

Study Type : In Vitro Study

Additional Links

Substances : Bee Venom

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , MicroRNA modulator

Additional Keywords : Exosomes

[+]

Mi-RNA-888-5p is involved in S-adenosylmethionine antitumor effects in laryngeal squamous cancer cells.Dec 06, 2020

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Pubmed Data : Biochem Biophys Res Commun. 2019 Jan 1 ;508(1):97-101. Epub 2018 Nov 22. PMID: 30471854

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Atherosclerosis, Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, MicroRNA modulator

[+]

Novel regulation of miR-34a-5p and HOTAIR by the combination of berberine and gefitinib leading to inhibition of EMT in human lung cancer.Apr 04, 2020

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Pubmed Data : J Cell Mol Med. 2020 Apr 5. Epub 2020 Apr 5. PMID: 32248643

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Pubmed Data : Front Pharmacol. 2018 ;9:1105. Epub 2018 Nov 20. PMID: 30515094

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, MicroRNA modulator

Additional Keywords : Exosomes

[+]

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:947-954. Epub 2018 Apr 24. PMID: 29710511

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor

[+]

polyphenols are able to modify epigenetic mechanisms promoting immune modulationJun 30, 2013

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Quercetin alleviated lipopolysaccharide-stimulated injury by up-regulating miR-124.Dec 04, 2019

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Pubmed Data : Biofactors. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804760

Article Published Date : Dec 04, 2019

Study Type : In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, MicroRNA modulator

[+]

Quercetin induces MiR-200b-3p which could inhibit cancer stem cells self-renewal and proliferation.Jan 30, 2017

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Pubmed Data : Mol Cancer. 2017 Jan 31 ;16(1):23. Epub 2017 Jan 31. PMID: 28137273

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Pubmed Data : Molecules. 2019 Dec 23 ;25(1). Epub 2019 Dec 23. PMID: 31878082

Resveratrol induces apoptosis in a time and dose dependent manner in CCRF-CEM cells. Dec 31, 2014

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(15):6463-8. PMID: 26434860

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Apoptotic, MicroRNA modulator

[+]

Resveratrol inhibits pulmonary fibrosis by regulating miR-21 through MAPK/AP-1 pathways.May 25, 2018

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Pubmed Data : Biomed Pharmacother. 2018 May 26 ;105:37-44. Epub 2018 May 26. PMID: 29843043

Article Published Date : May 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2015 Dec ;18(12):1209-14. PMID: 26877850

Article Published Date : Nov 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, MicroRNA modulator

Additional Keywords : Dose Response

[+]

Silibinin encapsulation in polymersome is a promising anticancer nanoparticle against human breast cancer cells.Nov 30, 2019

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Pubmed Data : J Cell Physiol. 2019 Dec ;234(12):22285-22298. Epub 2019 May 9. PMID: 31073992

Article Published Date : Nov 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, MicroRNA modulator

[+]

Silibinin induced apoptosis and downregulated microRNA in MCF-7 human breast cancer cells.Feb 29, 2016

Sulforaphane inhibited cancer stemness through miR-200c induction, which resulted in the inhibition of the self-renewal, metastasis, and tumor initiation.Feb 11, 2016

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Pubmed Data : J Formos Med Assoc. 2016 Feb 12. Epub 2016 Feb 12. PMID: 26879838

Article Published Date : Feb 11, 2016

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Oral Cancer

Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Chemopreventive, MicroRNA modulator

Additional Keywords : Cancer Stem Cells

[+]

Sulforaphane inhibits the activation of hepatic stellate cell by miRNA-423-5p targeting suppressor of fused.Sep 30, 2019

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Pubmed Data : Hum Cell. 2019 Oct ;32(4):403-410. Epub 2019 Jul 5. PMID: 31278688

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator

[+]

Sulforaphane, quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras.Sep 30, 2014

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Pubmed Data : Biochimie. 2019 May 9. Epub 2019 May 9. PMID: 31078586

Article Published Date : May 08, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Chemosensitizer, MicroRNA modulator

Additional Keywords : Cancer Stem Cells

[+]

Tanshinone IIA could represent a promising candidate for heart failure therapy.Dec 31, 2015

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Pubmed Data : Eur J Pharmacol. 2019 Apr 16. Epub 2019 Apr 16. PMID: 31002779

Article Published Date : Apr 15, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Cerebral Ischemia

Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents

[+]

Tanshinone IIA reduces oxidized low-density lipoprotein-induced inflammatory responses.Dec 31, 2018

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Pubmed Data : Ann N Y Acad Sci. 2017 Jun 29. Epub 2017 Jun 29. PMID: 28662290

Article Published Date : Jun 28, 2017

Study Type : In Vitro Study

Additional Links

Substances : Pterostilbene, Resveratrol

Diseases : Prostate Cancer

Pharmacological Actions : Chemopreventive, MicroRNA modulator

[+]

These data provides evidence to utilize the EGCG and silibinin combination as a novel approach to target tumor angiogenesis in the future.May 30, 2019

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Pubmed Data : ACS Omega. 2019 May 31 ;4(5):8421-8430. Epub 2019 May 13. PMID: 31459931

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Pubmed Data : Biomed Pharmacother. 2018 Oct ;106:665-671. Epub 2018 Jul 11. PMID: 29990856

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Laryngeal Cancer

Pharmacological Actions : Apoptotic, MicroRNA modulator, Tumor Suppressor Protein p53 Upregulation

[+]

These findings suggest that ursolic acid inhibits osteoclast differentiation through targeting XPO5.Mar 26, 2019

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Pubmed Data : Biol Pharm Bull. 2018 ;41(9):1440-1447. PMID: 30175778

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Propolis: Brazillian, Royal Jelly

Diseases : Allergic Rhinitis

Pharmacological Actions : MicroRNA modulator

[+]

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Pubmed Data : Oncotarget. 2017 Aug 29 ;8(35):58072-58085. Epub 2017 Jul 22. PMID: 28938538

Article Published Date : Aug 28, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, MicroRNA modulator, Vascular Endothelial Growth Factor A Enhancer

[+]

This suggests the potential of using fucoidan against the invasion and metastasis of liver cancer.Sep 23, 2015

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[+]

Urtica dioica extract could inhibit breast cancer cell migration.Jun 15, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Jun 16 ;93:95-102. Epub 2017 Jun 16. PMID: 28628833

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Pubmed Data : Mol Cell Biochem. 2016 Jun 13. Epub 2016 Jun 13. PMID: 27295094

Article Published Date : Jun 12, 2016

Study Type : In Vitro Study

Additional Links

Substances : Vitamin D

Diseases : HIV Infections

Pharmacological Actions : MicroRNA modulator

[+]

Xanthohumol regulates miR-4749-5p-inhibited RFC2 signalling in enhancing temozolomide cytotoxicity to glioblastoma. May 14, 2020

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Pubmed Data : Life Sci. 2020 May 15:117807. Epub 2020 May 15. PMID: 32422304

Article Published Date : May 14, 2020

Study Type : In Vitro Study

Additional Links

Substances : Xanthohumol

Diseases : Glioblastoma

Pharmacological Actions : Chemosensitizer, Chemotherapeutic, MicroRNA modulator

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

[+]

Xanthohumol upregulated miR-204-3p and induced apoptosis in glioma cells.Oct 31, 2016

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Pubmed Data : Neuropharmacology. 2016 Nov ;110(Pt A):362-75. Epub 2016 Jul 31. PMID: 27487563

Article Published Date : Oct 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Xanthohumol

Diseases : Glioblastoma

Pharmacological Actions : Apoptotic, MicroRNA modulator

[+]

β-Sitosterol regulated microRNAs in endothelial cells against an oxidized low-density lipoprotein.Feb 25, 2020

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Pubmed Data : Food Funct. 2020 Feb 26 ;11(2):1881-1890. PMID: 32068754

Article Published Date : Feb 25, 2020

Study Type : In Vitro Study

Additional Links

Substances : Beta Sitosterol

Diseases : Lipid Peroxidation

Pharmacological Actions : MicroRNA modulator

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View the Evidence: 593 Abstracts with MicroRNA modulator Research

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Blueberry phenolics reduce gastrointestinal infection of patients with cerebral venous thrombosis.Dec 31, 2016

Bufalin inhibits cell proliferation and induces mitochondria-dependent apoptosis in osteosarcoma cells.Dec 31, 2015

Bufalin inhibits cellular proliferation and cancer stem cell-like phenotypes via upregulation of MiR-203 in glioma.Nov 22, 2017

Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b.Aug 31, 2019

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.Mar 06, 2017

Cafestol may be a novel agent for bone diseases.Jun 30, 2015

Calcitriol potentiates the anti-HCV effect of miR-130a in both Con1b replicon and J6/JFH1 culture systems.Dec 31, 2014

Camel milk could protect against or decrease the deleterious effects of many environmental toxicants and carcinogens such as PAHs.Dec 31, 2011

Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells.Dec 27, 2018

Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression.Jan 23, 2017

Cardioprotective effect of paeonol against epirubicin-induced heart injury.Apr 24, 2018

Carnosic acid might be a prospective therapeutic drug for liver fibrosis.Dec 31, 2016

Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells.Apr 30, 2018

Celastrol inhibits growth and metastasis of human gastric cancer cell MKN45 by down-regulating microRNA-21.May 31, 2019

Celastrol may inhibit colon cancer cell proliferation by negatively regulating miR-21 and the PI3K/AKT/GSK-3β pathway.Dec 31, 2018

Cell cycle regulation by berberine in human melanoma A375 cells.Jul 31, 2020

Chemicals from the diet can influence the expression of functionally important long noncoding RNAs.Jan 11, 2017

Chlorogenic acid can regulate theapoptosis of non-small lung cancer through Notch pathway.Aug 19, 2017

Citrus aurantium dry extracts ameliorate adipocyte differentiation of 3T3-L1 cells exposed to TNFα by down-regulating miR-155 expression. May 27, 2020

Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells.Apr 23, 2019

Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration.Jul 19, 2017

Combined curcumin and temozolomide treatment significantly inhibited U 87 MG cell proliferation and induced apoptotic death, compared with each alone.Jul 16, 2015

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression.Nov 05, 2018

Cowpea is a promising anti-inflammatory dietary component by down regulation of proinflammatory cytokines.Oct 09, 2014

Curcumin as a MicroRNA Regulator in Cancer: A Review.Jul 22, 2016

Curcumin could increase the expression of hsa-miR-138, hsa-miR-138 inhibited cell proliferation and invasive ability.Dec 31, 2014

Curcumin decreases miR-21 levels through both increasing miR-21 exosome exclusion from the cells and inhibiting the transcription of the miR-21 gene.Nov 30, 2015

Curcumin induces p16 and its downstream target miR-146b-5p and suppresses IL-6.Aug 16, 2015

Curcumin inhibited cell proliferation and induced apoptosis of human non-small cell lung cancer cells.Sep 07, 2015

Curcumin inhibited oral squamous cell carcinoma cells proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling.Oct 29, 2014

Curcumin inhibits cancer progression through regulating expression of microRNAs.Jan 31, 2017

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells.Nov 17, 2014

Curcumin inhibits the proliferation, migration, invasion, and apoptosis of diffuse large B-cell lymphoma cell line.Dec 31, 2019

Curcumin intake affects miRNA signature in murine melanoma.Dec 31, 2012

Curcumin modulates chronic myelogenous leukemia exosomes compositionMar 29, 2016

Curcumin modulates miR-19/PTEN/AKT/p53 axis to exhibit its protective effects against BPA-associated breast cancer promotion.Sep 30, 2014

Curcumin prevented human autocrine growth hormone signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated EMT in T47D breast cancer cells.Nov 22, 2018

Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases.May 29, 2016

Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer.Jan 09, 2020

Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

Cyanidin-3-glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway.Dec 31, 2018

Cytoprotective effects of galacto-oligosaccharides on colon epithelial cells via up-regulating miR-19b.Aug 14, 2019

Defective insulin receptor signaling in patients with gestational diabetes is related to dysregulated miR-140 which can be improved by naringenin.Aug 15, 2020

Delphinidin suppresses breast carcinogenesis through HOTAIR/microRNA-34a axis.Jul 18, 2019

Demethoxycurcumin hindered ovarian cancer cells' malignant progress via up-regulating miR-551a.Feb 28, 2017

Dietary administration of black raspberry inhibits oral carcinogenesis via inhibition of pro-inflammatory and anti-apoptotic pathways.Dec 31, 2016

Dietary factors modify miRNA expression and their mRNA targets in various cancer processes.Oct 31, 2011

DNC potentially can induce DNA hypomethylation and re-expression of silenced tumor suppressor genes in HCC.Sep 14, 2015

Downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer.Mar 31, 2015

Dynamic regulation of miRNA expression by functionally enhanced placental Mesenchymal Stem Cells promotes hepatic regeneration in a rat model with bile duct ligation.Oct 24, 2019

EGCG decreases osteopontin mRNA and secreted OPN protein levels by decreasing the half-life of OPN mRNA in MHCC-97H cells.Jul 16, 2015

EGCG exerts anti-melanoma activity in a 67LR-dependent manner.Dec 31, 2015

EGCG has a protective role in hypoxia-induced impairment in mesenchymal stem cells.Jan 15, 2016

EGCG has an anticancer effect on Osteosarcoma cells.Mar 31, 2016

EGCG inhibits cancer stem cells-like properties through targeting miR-485/CD44 axis in A549-cisplatin resistant cells.Sep 03, 2018

EGCG may be considered a novel anti-cervical cancer drug in the future.Feb 28, 2019

EGCG may have benefit as a protective agent in settings of liver injury.Dec 31, 2015

EGCG significantly inhibits HPV11 oncogenes expression in vitro. May 08, 2016

EGCG suppresses lung cancer cell growth through upregulating miR-210 expression.Nov 30, 2011

Emodin could regulate Notch1 and RhoA/ROCK pathways by regulating the miR-218a-5p expression in the intestine.Dec 31, 2019

Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics.Sep 17, 2019

Exosomes derived from epigallocatechin gallate-treated cardiomyocytes attenuated acute myocardial infarction.Dec 31, 2019

Exosomes derived from miR-143-overexpressing MSCs inhibit cell migration and invasion in human prostate cancer.Aug 15, 2019

Fermented barley extracts with Lactobacillus plantarum dy-1 rich in vanillic acid modulate glucose consumption in human HepG2 cells.Dec 31, 2017

Folic acid protected neuronal cells against aluminium maltolate induced apoptosis.Apr 24, 2016

Formononetin can inhibit the growth of cervical cancer and reduce the mRNA and protein expression levels of HIF-1α and VEGF.Aug 31, 2019

Formononetin inhibits colon carcinoma cell growth and invasion.May 31, 2018

Formononetin inhibits human bladder cancer cell proliferation and invasiveness.Mar 21, 2017

Fucoidan affects oral squamous cell carcinoma cell functions in vitro by regulating FLNA-derived circular RNA.Sep 07, 2019

Galangin inhibits cholangiocarcinoma cell growth and metastasis.Dec 31, 2019

Ganoderma lucidum could be a potential cardioprotective agent.Dec 31, 2015

Garcinol has the potential as an antagonist against pancreatic cancer stem-like cells.Sep 23, 2015

View the Evidence:
593 Abstracts with MicroRNA modulator Research