MicroRNA modulator

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90 Substances Researched for MicroRNA modulator
NameACCKFocus
Curcumin2739Locked
EGCG (Epigallocatechin gallate)1827Locked
Polyphenols1023Locked
Berberine916Locked
Flavonoids212Locked
Quercetin711Locked
Vitamin C211Locked
Chlorella (Algae)110Locked
Chocolate110Locked
Resveratrol58Locked
Sulforaphane77Locked
Oridonin26Locked
Pterostilbene36Locked
Genistein45Locked
Silymarin15Locked
Spirulina15Locked
Apigenin34Locked
Delta-tetrahydrocannabinol (THC)24Locked
Grape24Locked
Silibinin34Locked
Blueberry23Locked
Catechin 33Locked
Cucurbitacin E 23Locked
Emodin23Locked
Ginseng (Korean)23Locked
Honokiol23Locked
Indole-3-Carbinol23Locked
Melatonin23Locked
Reishi Mushroom23Locked
Selenium23Locked
Tocotrienol: Delta23Locked
Ursolic Acid23Locked
Vitamin D33Locked
Xanthohumol23Locked
Achiote12Locked
Amla Fruit12Locked
Boswellia12Locked
Cannabis12Locked
Carnosic Acid12Locked
Chokeberry12Locked
Citrus naringin12Locked
Fish Oil12Locked
Ginsenosides12Locked
Glycyrrhizin12Locked
Jambul 12Locked
Kaempferol12Locked
Magnolia12Locked
Mango 12Locked
Moringa oleifera12Locked
Naringenin 12Locked
Nigella sativa (aka Black Seed)12Locked
Nobiletin 22Locked
Potato: Pigmented12Locked
Prunella vulgaris.12Locked
Sweet Potato: Purple12Locked
Tangeretin 12Locked
Thymoquinone12Locked
Tripterygium wilfordii12Locked
Triptolide12Locked
Turmeric12Locked
Vitamin E: Gamma-tocotrienol12Locked
Walnut12Locked
beta-Carotene12Locked
6-Shogaol11Locked
Aloe Vera11Locked
Arctigenin11Locked
Camel Milk 11Locked
Cruciferous Vegetables11Locked
Fiber11Locked
Folate11Locked
Folic Acid 11Locked
Garcinia indica11Locked
Green Tea11Locked
Huaier (Trametes robiniophila murr)11Locked
Isoflavones11Locked
Isothiocyanates11Locked
Legumes11Locked
Licorice11Locked
Mangiferin11Locked
Mistletoe11Locked
Olive leaf extract11Locked
Phenethyl isothiocyanate11Locked
Phospholipids11Locked
Polyunsaturated Fatty Acids (PUFAs)11Locked
Pomegranate Peel11Locked
Pomegranate Polyphenols11Locked
Puerarin11Locked
Tannic Acid11Locked
Vitamin A11Locked
Vitamin E11Locked

View the Evidence:
360 Abstracts with MicroRNA modulator Research

[+]

Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis.Apr 10, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 Apr 11. Epub 2018 Apr 11. PMID: 29654764
Article Published Date : Apr 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Rosmarinic acid might potentially be a therapeutic agent for suppressing the Warburg effect in gastric carcinoma.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2015 ;9:2695-703. Epub 2015 May 19. PMID: 26056431
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Gastric Cancer, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, MicroRNA modulator
Additional Keywords : Warburg Effect
[+]

S-Adenosylmethionine regulates apoptosis and autophagy in MCF-7 breast cancer cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2018 ;18:197. Epub 2018 Dec 4. PMID: 30533999
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : S-Adenosylmethionine (SAMe)
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Chemopreventive, MicroRNA modulator
[+]

Shikonin suppresses proliferation and induces apoptosis in endometrioid endometrial cancer cells.Feb 14, 2018

Pubmed Data : Biosci Rep. 2018 Feb 15. Epub 2018 Feb 15. PMID: 29449346
Article Published Date : Feb 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Endometrial Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator
[+]

Shikonin-mediated up-regulation of miR-34a and miR-202 inhibits retinoblastoma proliferation.Aug 31, 2018

Pubmed Data : Toxicol Res (Camb). 2018 Sep 1 ;7(5):907-912. Epub 2018 Jun 6. PMID: 30310667
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Retinoblastoma
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Silibinin decreased expression of miR-21 and miR-155 in treated cells.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Dec ;18(12):1209-14. PMID: 26877850
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator
Additional Keywords : Dose Response
[+]

Silibinin induced apoptosis and downregulated microRNA in MCF-7 human breast cancer cells.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Breast Cancer. 2016 Mar ;19(1):45-52. Epub 2016 Mar 25. PMID: 27066095
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator
[+]

Spica Prunellae can suppress the growth of HCT-8 cells.Aug 31, 2017

Pubmed Data : Oncol Rep. 2017 Sep ;38(3):1895-1901. Epub 2017 Jul 6. PMID: 28713966
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Prunella vulgaris
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
Additional Keywords : Dose Response
[+]

Steroidogenic effects of Taraxacum officinale extract on the levels of steroidogenic enzymes in mouse Leydig cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anim Cells Syst (Seoul). 2018 ;22(6):407-414. Epub 2018 Nov 8. PMID: 30533263
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Hypogonadism
Pharmacological Actions : Enzyme Inhibitors, MicroRNA modulator
[+]

Sulforaphane and epigallocatechin-3-gallate (EGCG) can positively modulate the epigenome and lead to many health benefits.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Biol. 2015 Jan 1 ;218(Pt 1):59-70. PMID: 25568452
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification, Histone Modifications
[+]

Sulforaphane attenuates Ang II-induced hypertrophy of H9c2 cardiomyocytes mediated by the inhibition of intracellular signaling pathways including Akt and NF-κB.Apr 30, 2014

Pubmed Data : Herz. 2014 May ;39(3):390-6. Epub 2013 Jun 21. PMID: 23784363
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Sulforaphane could be considered as a potential adjuvant therapeutic agent in treating glioblastoma patients combined with temozolomide.May 19, 2015

Pubmed Data : J Neurochem. 2015 May 20. Epub 2015 May 20. PMID: 25991372
Article Published Date : May 19, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions : Chemopreventive, Chemotherapeutic, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression.Feb 08, 2018

Pubmed Data : J Nutr Biochem. 2018 Feb 9 ;56:109-115. Epub 2018 Feb 9. PMID: 29525530
Article Published Date : Feb 08, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer
Pharmacological Actions : MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties.Nov 07, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Nov 8 ;6:36796. Epub 2016 Aug 8. PMID: 27824145
Article Published Date : Nov 07, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Gastric Cancer
Pharmacological Actions : Chemosensitizer, MicroRNA modulator
Additional Keywords : Cancer Stem Cells, Chemotherapeutic Synergy: Cisplatin, Natural Substance/Drug Synergy
[+]

Sulforaphane inhibited cancer stemness through miR-200c induction, which resulted in the inhibition of the self-renewal, metastasis, and tumor initiation.Feb 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Formos Med Assoc. 2016 Feb 12. Epub 2016 Feb 12. PMID: 26879838
Article Published Date : Feb 11, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Oral Cancer
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Chemopreventive, MicroRNA modulator
Additional Keywords : Cancer Stem Cells
[+]

Sulforaphane, quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2014 Oct ;45(4):1391-400. Epub 2014 Jul 8. PMID: 25017900
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Quercetin, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, MicroRNA modulator
Additional Keywords : Cancer Stem Cells, K-ras Inhibition, Natural Substance Synergy, Plant Extracts
[+]

Tannic acid inhibits proliferation, migration, invasion of prostate cancer and modulates drug metabolizing and antioxidant enzymes.Nov 09, 2015

Pubmed Data : Anticancer Agents Med Chem. 2015 Nov 10. Epub 2015 Nov 10. PMID: 26555610
Article Published Date : Nov 09, 2015
Study Type : In Vitro Study
Additional Links
Substances : Tannic Acid
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator
Additional Keywords : Dose Response
[+]

Tanshinone IIA ameliorates apoptosis of myocardiocytes by up-regulation of miR-133 and suppression of caspase-9.Nov 14, 2017

Pubmed Data : Eur J Pharmacol. 2017 Nov 15 ;815:343-350. Epub 2017 Sep 1. PMID: 28867607
Article Published Date : Nov 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Chemoprotective Agents, MicroRNA modulator
[+]

Tanshinone IIA ameliorates lipopolysaccharide-induced inflammatory response in bronchial epithelium cell line BEAS-2B.Jul 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:158-164. Epub 2018 May 15. PMID: 29772436
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : MicroRNA modulator
[+]

Tanshinone IIA could attenuate the stemness of breast cancer cells.May 08, 2019

Pubmed Data : Biochimie. 2019 May 9. Epub 2019 May 9. PMID: 31078586
Article Published Date : May 08, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer, MicroRNA modulator
Additional Keywords : Cancer Stem Cells
[+]

Tanshinone IIA could represent a promising candidate for heart failure therapy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2016 ;8(7):3124-32. Epub 2016 Jul 15. PMID: 27508033
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Heart Failure
Pharmacological Actions : Cardioprotective, MicroRNA modulator
[+]

Tanshinone IIA protects H9c2 cells from oxidative stress-induced cell death.Jul 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Aug ;12(2):1147-1152. Epub 2016 May 26. PMID: 27446335
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, MicroRNA modulator
[+]

Tanshinone IIA protects hypoxia-induced injury by preventing microRNA-28 up-regulation in PC-12 cells.Apr 15, 2019

Pubmed Data : Eur J Pharmacol. 2019 Apr 16. Epub 2019 Apr 16. PMID: 31002779
Article Published Date : Apr 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Cerebral Ischemia
Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents
[+]

Tanshinone ⅡA inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation.Jan 14, 2016

Pubmed Data : Arch Biochem Biophys. 2016 05 15 ;598:50-6. Epub 2016 Mar 31. PMID: 27040384
Article Published Date : Jan 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Esophageal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , MicroRNA modulator
[+]

Tanshinone-IIA Tan IIA could exert an anti-inflammatory effect on LPS-induced RAW264.7 cells.Jan 31, 2016

Pubmed Data : Inflammation. 2016 Feb ;39(1):375-384. PMID: 26639663
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

The activation of miR-429 by delta-tocotrienol may be an effective approach for the prevention and treatment of triple-negative breast cancer.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(9):15648-56. Epub 2015 Sep 15. PMID: 26629059
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Chemopreventive, MicroRNA modulator
[+]

The combination of Arc and Q that target similar pathways, at low physiological doses, provides a novel regimen with enhanced chemoprevention in prostate cancer.Jan 31, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Feb ;59(2):250-61. Epub 2014 Dec 5. PMID: 25380086
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin, Quercetin
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, MicroRNA modulator
Additional Keywords : Natural Substance Synergy
[+]

The in vitro activity of Angelica archangelica essential oil on inflammation.Aug 28, 2018

Pubmed Data : J Med Food. 2018 Aug 29. Epub 2018 Aug 29. PMID: 30156459
Article Published Date : Aug 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Angelica
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
Additional Keywords : Essential Oils
[+]

The present results indicate that Reishi might reduce the risk of intestinal infection.Mar 24, 2018

Pubmed Data : J Ethnopharmacol. 2018 Mar 25 ;214:240-243. Epub 2017 Dec 14. PMID: 29248453
Article Published Date : Mar 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Pharmacological Actions : Immunomodulatory, MicroRNA modulator
[+]

The present review article highlights the anticancer perspectives of thymoquinone in human by various pathways.Jun 28, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun 29 ;106:390-402. Epub 2018 Jun 29. PMID: 29966985
Article Published Date : Jun 28, 2018
Study Type : Review
Additional Links
Substances : Thymoquinone
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Apoptotic, Chemopreventive, MicroRNA modulator, NF-kappaB Inhibitor
[+]

The present review explores the potential anti-metastatic mechanisms of curcumin.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2016 Nov ;36(11):5639-5647. PMID: 27793885
Article Published Date : Oct 31, 2016
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Interleukin-6 Downregulation, Interleukin-8 downregulation, MicroRNA modulator, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

The present study demonstrated the potential anticancer effects of apigenin on glioma cells.Jun 29, 2016

Pubmed Data : Mol Med Rep. 2016 Jun 30. Epub 2016 Jun 30. PMID: 27430517
Article Published Date : Jun 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, MicroRNA modulator
Additional Keywords : Dose Response
[+]

The present study proposes that piceatannol can be taken into account to be a hopeful anticancer agent for melanoma.Oct 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Res. 2017 Oct 17 ;50(1):36. Epub 2017 Oct 17. PMID: 29041990
Article Published Date : Oct 16, 2017
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Melanoma
Pharmacological Actions : Apoptotic, Chemopreventive, MicroRNA modulator
[+]

The present study showed that berberine, baicalin, emodin, and schizandrin all have antibacterial activities against MDR, and can reduce the MICs of amoxicillin and tetracycline.Apr 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Apr 14 ;21(14):4225-31. PMID: 25892872
Article Published Date : Apr 13, 2015
Study Type : In Vitro Study
Additional Links
Substances : Berberine, Emodin
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents, MicroRNA modulator
Additional Keywords : Multi-Drug Resistant Pathogens, Natural Substance/Drug Synergy
[+]

The proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non small cell lung cancer.Jan 31, 2015

Pubmed Data : Cancer Lett. 2015 Feb 1 ;357(1):196-205. Epub 2014 Nov 18. PMID: 25444916
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Apoptotic, MicroRNA modulator, Tumor Suppressor Protein p53 Upregulation
[+]

The use of resveratrol and its analogs as an attractive miRNA-mediated chemopreventive and therapeutic strategy in prostate cancer.Jun 28, 2017

Pubmed Data : Ann N Y Acad Sci. 2017 Jun 29. Epub 2017 Jun 29. PMID: 28662290
Article Published Date : Jun 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene, Resveratrol
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive, MicroRNA modulator
[+]

These findings demonstrate an attractive therapeutic potential for solasodine in lung cancer anti-metastatic therapy.Apr 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Apr 25 ;268:129-135. Epub 2017 Mar 7. PMID: 28283413
Article Published Date : Apr 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Eggplant
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, MicroRNA modulator
[+]

These findings demonstrate that fucoidan inhibits breast cancer progression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2016 ;7(15):2408-2419. Epub 2016 Dec 9. PMID: 27994679
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Seaweed: Brown
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Chemotherapeutic, MicroRNA modulator
[+]

These findings demonstrate, for the first time, that the growth suppressive effect of XN in pancreatic cancer cells is mainly mediated by Notch1 reduction.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cancer Ther. 2015 Jun ;14(6):1395-403. Epub 2015 Apr 17. PMID: 25887885
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator
Additional Keywords : Dose Response
[+]

These findings may provide novel mechanistic insight into the anti-obesity effects of berberine.Aug 31, 2016

Pubmed Data : Mol Med Rep. 2016 Sep ;14(3):2725-31. Epub 2016 Jul 25. PMID: 27484069
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Obesity
Pharmacological Actions : MicroRNA modulator
Additional Keywords : Anti-Obesity Agents
[+]

These findings reveal a novel molecular mechanism underlying the inhibitory effects of β-elemene on lung cancer cells.Sep 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Mol Med. 2018 Sep 12 ;50(9):121. Epub 2018 Sep 12. PMID: 30209296
Article Published Date : Sep 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Lung Cancer
Pharmacological Actions : MicroRNA modulator, STAT3 Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

These findings suggest 3-acetyl-11-keto-β-boswellic acid as a therapeutic drug for alleviating the symptoms of neuroinflammatory disorders.Oct 26, 2017

Pubmed Data : Mol Neurobiol. 2017 Oct 27. Epub 2017 Oct 27. PMID: 29079998
Article Published Date : Oct 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Frankincense
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, Neuroprotective Agents
[+]

These findings suggest that genistein can suppress laryngeal cancer cell survival.Sep 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Oct ;106:665-671. Epub 2018 Jul 11. PMID: 29990856
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Laryngeal Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator, Tumor Suppressor Protein p53 Upregulation
[+]

These findings suggest that ursolic acid inhibits osteoclast differentiation through targeting XPO5.Mar 26, 2019

Pubmed Data : J Agric Food Chem. 2019 Mar 27 ;67(12):3333-3340. Epub 2019 Mar 18. PMID: 30827108
Article Published Date : Mar 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Loquat, Ursolic Acid
Diseases : Osteoporosis
Pharmacological Actions : MicroRNA modulator, Osteoprotective
Additional Keywords : Plant Extracts
[+]

These findings support dandelion extract might be a potential therapeutic approach to treat triple-negative breast cancer.Apr 27, 2017

Pubmed Data : J Ethnopharmacol. 2017 Apr 28. Epub 2017 Apr 28. PMID: 28461119
Article Published Date : Apr 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Cell cycle arrest, MicroRNA modulator
Additional Keywords : Gene Expression Regulation, Plant Extracts
[+]

These results demonstrated that sulforaphane possesses effective anti-HCV activity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(3):e0152236. Epub 2016 Mar 29. PMID: 27023634
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents, Heme oxygenase-1 up-regulation, MicroRNA modulator
Additional Keywords : Dose Response
[+]

These results imply that cucurbitacin E possesses powerful anti-encephalitogenic activity.Jun 21, 2016

Pubmed Data : J Agric Food Chem. 2016 Jun 22 ;64(24):4900-7. Epub 2016 Jun 8. PMID: 27225664
Article Published Date : Jun 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E
Diseases : Autoimmune Diseases, Encephalitis
Pharmacological Actions : Antioxidants, Interferon Gamma Reducer, Interleukin-17 downregulation, MicroRNA modulator, Nitric Oxide Inhibitor
[+]

These results indicated that miRNA-150-5p might be involved in the antihypertensive effect of EGCG.Jun 14, 2018

Pubmed Data : Life Sci. 2018 Jun 15 ;203:193-202. Epub 2018 Apr 27. PMID: 29705350
Article Published Date : Jun 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, MicroRNA modulator
Additional Keywords : Antihypertensive Agents, EGCG (Epigallocatechin gallate), hypertension, MicroRNA modulator
[+]

These results suggest that DIM may through the miR-30e-ATG5 modulating autophagy inhibit the proliferation of gastric cancer cells.Aug 31, 2016

Pubmed Data : Biochem Pharmacol. 2016 Sep 1 ;115:77-84. Epub 2016 Jun 29. PMID: 27372603
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
Additional Keywords : Dose Response
[+]

These results suggest that royal jelly and Brazilian green propolis could be good therapeutics against allergic rhinitis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2018 ;41(9):1440-1447. PMID: 30175778
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Propolis: Brazillian, Royal Jelly
Diseases : Allergic Rhinitis
Pharmacological Actions : MicroRNA modulator
[+]

These results thus demonstrate that VA-mediated inhibition of PGE2 implicates destabilization of COX-2 mRNA. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(2):e0114965. Epub 2015 Feb 9. PMID: 25664986
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mistletoe
Diseases : Inflammation, Lung Cancer
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, MicroRNA modulator, Prostaglandin PGE2 downregulation
[+]

These studies suggest that CBD-mediated apoptosis in neuroblastoma cells is regulated by miRNA.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2019 Jan 1 ;10(1):45-59. Epub 2019 Jan 1. PMID: 30713602
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Neuroblastoma
Pharmacological Actions : Apoptotic, MicroRNA modulator
[+]

This reviews the effects of butyrate on modulating miRNA expression in colorectal cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genet Epigenet. 2017 ;9:1179237X17729900. Epub 2017 Sep 25. PMID: 28979170
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Butyrate
Diseases : Colorectal Cancer
Pharmacological Actions : Chemoprotective Agents, MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

This study highlighted the potential therapeutic application of Tanshinone IIA against ovarian malignancy.Sep 30, 2018

Pubmed Data : J Pharm Pharmacol. 2018 Oct ;70(10):1369-1377. Epub 2018 Jun 25. PMID: 29943422
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator, Survivin Down-Regulation
[+]

This study identified RUNX2 as a regulator of ginsenoside Rg1-induced angiogenesis.Aug 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Aug 29 ;8(35):58072-58085. Epub 2017 Jul 22. PMID: 28938538
Article Published Date : Aug 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, MicroRNA modulator, Vascular Endothelial Growth Factor A Enhancer
[+]

This suggests the potential of using fucoidan against the invasion and metastasis of liver cancer.Sep 23, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2015 Sep 24 ;13(10):6099-116. Epub 2015 Sep 24. PMID: 26404322
Article Published Date : Sep 23, 2015
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, MicroRNA modulator
[+]

Ursolic acid inhibits the proliferation of gastric cancer cells by targeting miR-133a.Dec 31, 2014

Pubmed Data : Oncol Res. 2015 ;22(5):267-73. PMID: 26629938
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator
[+]

Urtica dioica extract could inhibit breast cancer cell migration.Jun 15, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jun 16 ;93:95-102. Epub 2017 Jun 16. PMID: 28628833
Article Published Date : Jun 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Nettle
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, MicroRNA modulator
Additional Keywords : Plant Extracts
[+]

Vitamin D3 inhibits TNFα-induced latent HIV reactivation in J-LAT cells.Jun 12, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jun 13. Epub 2016 Jun 13. PMID: 27295094
Article Published Date : Jun 12, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : HIV Infections
Pharmacological Actions : MicroRNA modulator
[+]

Xanthohumol upregulated miR-204-3p and induced apoptosis in glioma cells.Oct 31, 2016

Pubmed Data : Neuropharmacology. 2016 Nov ;110(Pt A):362-75. Epub 2016 Jul 31. PMID: 27487563
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic, MicroRNA modulator

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