MicroRNA modulator

Name	AC	CK
Curcumin	40	55
EGCG (Epigallocatechin gallate)	32	45
Berberine	27	39
Tanshinone IIA	27	36
Polyphenols	15	29
Ginsenosides	20	27
Resveratrol	15	27
Flavonoids	5	24
Quercetin	19	24
Vitamin C	3	21
Vitamin D	9	21
Astaxanthin	6	18
Astragaloside	13	18
Goji	5	17
Sulforaphane	15	16
Pterostilbene	10	15
Fucoidan	4	14
Paeonol	9	14
Genistein	10	13
Luteolin	10	13
Probiotics	2	12
Puerarin	9	12
Oleanolic acid	2	11
Apigenin	8	10
Chlorella (Algae)	1	10
Chocolate	1	10
Crocin	5	10
Licorice	8	10
Purslane	1	10
Vitamin B-12	1	10
Citrus naringin	5	9
Emodin	6	9
Myricetin	3	9
Oridonin	4	9
Shikonin	7	9
Delta-tetrahydrocannabinol (THC)	4	8
Formononetin	6	8
Indole-3-Carbinol	5	8
Xanthohumol	6	8
Kaempferol	6	7
Lactobacillus plantarum	4	7
Melatonin	6	7
Panax Notoginseng	4	7
Selenium	4	7
Spirulina	2	7
Thymoquinone	5	7
Ursolic Acid	6	7
Angelica	6	6
Ligustrazine	5	6
Mulberry	4	6
Silibinin	5	6
Asiatic Acid	3	5
Beta-Elemene	4	5
Blueberry	4	5
Delphinidin	3	5
Gallic Acid	3	5
Ginger	3	5
Ginseng (Siberian)	1	5
Grape Seed Extract	3	5
Honokiol	4	5
Isoliquiritigenin	3	5
Moringa oleifera	3	5
Naringenin	4	5
Oleuropein	5	5
Reishi Mushroom	4	5
Silymarin	1	5
Vitamin K2	1	5
Carnosic Acid	3	4
Diosgenin	2	4
Flaxseed	2	4
Gastrodin	3	4
Grape	2	4
Hesperidin	3	4
Lotus	4	4
Nobiletin	4	4
Paeoniflorin	4	4
Pomegranate	2	4
Barley	2	3
Bee Venom	2	3
Bufalin	3	3
Catechin	3	3
Cucurbitacin E	2	3
Curcumol	3	3
Ellagic Acid	2	3
Fermented Foods and Beverages	2	3
Ginseng (Korean)	2	3
Green Tea	2	3
Lactoferrin	3	3
Mangiferin	3	3
Omega-3 Fatty Acids	2	3
Polyunsaturated Fatty Acids (PUFAs)	2	3
Prunella vulgaris	2	3
Tangeretin	2	3
Tocotrienol: Delta	2	3
Vitamin E	2	3
2-Methoxyestradiol	1	2
Achiote	1	2
Allicin	2	2
Alpha Linolenic Acid	1	2
Amla Fruit	1	2
Apple Polyphenols	1	2
Artesunate	2	2
Benzyl isothiocyanate	2	2
Black Raspberry	2	2
Boswellia	1	2
Butyrate	2	2
Caffeic Acid	1	2
Caffeic acid phenethyl ester	1	2
Cannabidiol	2	2
Cannabis	1	2
Carotenoids	1	2
Celastrol	2	2
Chlorogenic Acid	2	2
Chokeberry	1	2
Coenzyme Q10	1	2
Corn Silk	1	2
Cranberry	1	2
Crocetin	1	2
Cryptoxanthin	1	2
Cucurbitacin B	1	2
Cucurbitacin D	1	2
Dandelion	2	2
Evodiamine	1	2
Fish Oil	1	2
Garlic	2	2
Genipin	1	2
Geraniol	1	2
Ginkgo biloba	1	2
Glycyrrhizin	1	2
Gold (nanoparticles)	1	2
Gotu Kola	1	2
Gynostemma	1	2
Isoquercitrin	1	2
Isothiocyanates	2	2
Jambul	1	2
Litchi	1	2
Lychee	1	2
Lycopene	1	2
Magnolia	1	2
Mango	1	2
Mangosteen	1	2
NAC (N-acetyl-L-cysteine)	1	2
Nigella sativa (aka Black Seed)	1	2
Nordihydroguaiaretic acid (NDGA)	1	2
Patchouli	1	2
Peony	2	2
Piceatannol	2	2
Pineapple	1	2
Piperlongumine	2	2
Potato: Pigmented	1	2
Pumpkin Seeds	1	2
Pycnogenol (Pine Bark)	1	2
Rice Bran	1	2
Rutin	1	2
S-Adenosylmethionine (SAMe)	2	2
Sweet Potato: Purple	1	2
Tripterygium wilfordii	1	2
Triptolide	1	2
Turmeric	1	2
Vitamin E: Gamma-tocotrienol	1	2
Vitamin E: alpha tocopherol	1	2
Vitexins	1	2
Walnut	1	2
Zinc	1	2
beta-Carotene	1	2
6-Shogaol	1	1
Aloe Vera	1	1
Anthocyanins	1	1
Arctigenin	1	1
Ashwagandha	1	1
Berbamine	1	1
Beta Sitosterol	1	1
Bifidobacterium Bifidum	1	1
Bitter Orange	1	1
Cafestol	1	1
Camel Milk	1	1
Cardamonin	1	1
Citrus Peel	1	1
Cruciferous Vegetables	1	1
Cyanidin 3-glucoside	1	1
Demethoxycurcumin	1	1
Eggplant	1	1
Fiber	1	1
Folate	1	1
Folic Acid	1	1
Frankincense	1	1
Galactooligosaccharides	1	1
Garcinia indica	1	1
Huaier (Trametes robiniophila murr)	1	1
Hydroxytyrosol	1	1
Isoflavones	1	1
Kahweol	1	1
Lactobacillus Acidophilus	1	1
Legumes	1	1
Lentinan	1	1
Liquiritigenin	1	1
Loquat	1	1
Mistletoe	1	1
Nettle	1	1
Oligosaccharides	1	1
Olive Oil	1	1
Olive leaf extract	1	1
Onion	1	1
Phenethyl isothiocyanate	1	1
Phospholipids	1	1
Piperine	1	1
Pomegranate Peel	1	1
Pomegranate Polyphenols	1	1
Propolis: Brazillian	1	1
Psychedelics:All	1	1
Rhubarb	1	1
Rose	1	1
Rosemaric Acid	1	1
Royal Jelly	1	1
Salvia miltiorrhiza	1	1
Seaweed: Brown	1	1
Sweet Potato	1	1
Syrian rue	1	1
Tannic Acid	1	1
Urolithin A	1	1
Vitamin A	1	1
Zerumbone	1	1
acetyl-11-keto-beta-boswellic acid	1	1

[+]

Astragaloside IV protects guman cardiomyocytes from hypoxia/reoxygenation injury by regulating miR-101a May 10, 2020

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Pubmed Data : Iran J Basic Med Sci. 2016 Feb ;19(2):125-31. PMID: 27081456

Article Published Date : Jan 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, MicroRNA modulator

[+]

Berberine modulates ASK1 signaling mediated through TLR4/TRAF2 via upregulation of miR-23a.Sep 17, 2018

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Pubmed Data : Toxicol Appl Pharmacol. 2018 Sep 18. Epub 2018 Sep 18. PMID: 30240693

Article Published Date : Sep 17, 2018

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator

[+]

Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia.Feb 12, 2020

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Pubmed Data : Cell Physiol Biochem. 2017 Nov 23 ;44(2):671-681. Epub 2017 Nov 23. PMID: 29169175

Article Published Date : Nov 22, 2017

Study Type : In Vitro Study

Additional Links

Substances : Bufalin

Diseases : Glioma

Pharmacological Actions : Antiproliferative , MicroRNA modulator

Additional Keywords : Cancer Stem Cells

[+]

Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b.Aug 31, 2019

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Pubmed Data : Acta Pharmacol Sin. 2019 Sep ;40(9):1228-1236. Epub 2019 Apr 26. PMID: 31028291

Article Published Date : Aug 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bufalin

Diseases : Prostate Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , MicroRNA modulator

[+]

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.Mar 06, 2017

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Pubmed Data : Redox Biol. 2017 Mar 7 ;12:340-349. Epub 2017 Mar 7. PMID: 28288414

Article Published Date : Mar 06, 2017

Study Type : In Vitro Study

Additional Links

Substances : Butyrate

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator

Additional Keywords : Antiproliferative, Apoptotic, Butyrate, Histone deacetylase inhibitor, liver cancer, MicroRNA modulator

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[+]

Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells.Dec 27, 2018

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Pubmed Data : Transl Oncol. 2018 Dec 28 ;12(3):513-522. Epub 2018 Dec 28. PMID: 30597288

Article Published Date : Dec 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Chemotherapeutic, MicroRNA modulator

Additional Keywords : Exosomes

[+]

Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression.Jan 23, 2017

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Cell cycle regulation by berberine in human melanoma A375 cells.Jul 31, 2020

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Pubmed Data : Bull Exp Biol Med. 2020 Aug ;169(4):491-496. Epub 2020 Sep 11. PMID: 32915362

Article Published Date : Jul 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, MicroRNA modulator

[+]

Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells.Apr 23, 2019

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Pubmed Data : Biosci Biotechnol Biochem. 2019 Apr 24:1-9. Epub 2019 Apr 24. PMID: 31017523

Article Published Date : Apr 23, 2019

Study Type : In Vitro Study

Additional Links

Substances : Citrus Peel , Flavonoids, Hesperidin, Nobiletin , Tangeretin

Pharmacological Actions : Hypolipidemic, MicroRNA modulator

[+]

Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration.Jul 19, 2017

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Pubmed Data : Sci Rep. 2017 Jul 20 ;7(1):6015. Epub 2017 Jul 20. PMID: 28729651

Article Published Date : Jul 19, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Retinal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, MicroRNA modulator

[+]

Combined curcumin and temozolomide treatment significantly inhibited U 87 MG cell proliferation and induced apoptotic death, compared with each alone.Jul 16, 2015

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Pubmed Data : Mol Med Rep. 2015 Jul 17. Epub 2015 Jul 17. PMID: 26239619

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Pubmed Data : Front Oncol. 2021 ;11:651648. Epub 2021 Jul 6. PMID: 34295808

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Tongue Cancer

Pharmacological Actions : Antiproliferative , MicroRNA modulator

[+]

Curcumin as a MicroRNA Regulator in Cancer: A Review.Jul 22, 2016

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Pubmed Data : Rev Physiol Biochem Pharmacol. 2016 Jul 23. Epub 2016 Jul 23. PMID: 27457236

Article Published Date : Jul 22, 2016

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Cancers: All

Pharmacological Actions : MicroRNA modulator

[+]

Curcumin could increase the expression of hsa-miR-138, hsa-miR-138 inhibited cell proliferation and invasive ability.Dec 31, 2014

Pubmed Data : Tumour Biol. 2017 Feb ;39(2):1010428317691680. PMID: 28222667

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Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

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Pubmed Data : J Cancer. 2020 ;11(7):1679-1692. Epub 2020 Jan 14. PMID: 32194780

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, MicroRNA modulator

[+]

Curcumol inhibits the viability and invasion of colorectal cancer cells via miR-30a-5p and Hippo signaling pathway.Mar 31, 2021

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Pubmed Data : Phytomedicine. 2015 Sep 15 ;22(10):961-7. Epub 2015 Jul 14. PMID: 26321746

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Pubmed Data : PLoS One. 2016 ;11(12):e0167435. Epub 2016 Dec 9. PMID: 27935974

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator

[+]

EGCG significantly inhibits HPV11 oncogenes expression in vitro. May 08, 2016

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Pubmed Data : Drug Discov Today. 2019 Sep 18. Epub 2019 Sep 18. PMID: 31541714

Article Published Date : Sep 17, 2019

Study Type : Review

Additional Links

Substances : Thymoquinone

Diseases : Cancers: All

Pharmacological Actions : Chemotherapeutic, MicroRNA modulator

Additional Keywords : Epigenetic Modification In Cancer

[+]

Exosomal miR-512-3p derived from mesenchymal stem cells inhibits oxidized low-density lipoprotein-induced vascular endothelial cells dysfunction via regulating Keap1.Mar 23, 2021

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Pubmed Data : J Biochem Mol Toxicol. 2021 Mar 24:e22767. Epub 2021 Mar 24. PMID: 33760324

Article Published Date : Mar 23, 2021

Study Type : In Vitro Study

Additional Links

Diseases : Atherosclerosis, Endothelial Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, MicroRNA modulator

Additional Keywords : Exosomes

[+]

Exosomes derived from epigallocatechin gallate-treated cardiomyocytes attenuated acute myocardial infarction.Dec 31, 2019

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Pubmed Data : Ann N Y Acad Sci. 2019 Sep 8. Epub 2019 Sep 8. PMID: 31495936

Article Published Date : Sep 07, 2019

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator

[+]

Galangin inhibits cholangiocarcinoma cell growth and metastasis.Dec 31, 2019

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Pubmed Data : Biomed Res Int. 2020 ;2020:5846938. Epub 2020 Jun 11. PMID: 32626749

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Cholangiocarcinoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator

[+]

Ganoderma lucidum could be a potential cardioprotective agent.Dec 31, 2015

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Pubmed Data : Oncoscience. 2016 ;3(7-8):203-207. Epub 2016 Aug 28. PMID: 27713910

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Cardiovascular Diseases

Pharmacological Actions : Cardioprotective, MicroRNA modulator

Additional Keywords : Risk Reduction

[+]

Garcinol has the potential as an antagonist against pancreatic cancer stem-like cells.Sep 23, 2015

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Pubmed Data : Biotechnol Appl Biochem. 2015 Sep 24. Epub 2015 Sep 24. PMID: 26400206

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Pubmed Data : Biomed Pharmacother. 2019 Oct 16 ;120:109483. Epub 2019 Oct 16. PMID: 31629252

Article Published Date : Oct 15, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Non-Small-Cell Lung Carcinoma

Pharmacological Actions : Antiproliferative , MicroRNA modulator

[+]

Ginsenoside Rh2 exerts anti-metastasis activity in hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491.Jul 03, 2019

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Pubmed Data : Anticancer Agents Med Chem. 2019 Jul 4. Epub 2019 Jul 4. PMID: 31272362

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:624132. Epub 2015 Oct 12. PMID: 26579204

In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis.Apr 30, 2015

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Pubmed Data : Curr Pharmacol Rep. 2015 May ;1(3):179-196. Epub 2015 Jan 30. PMID: 26457242

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Pubmed Data : Front Pharmacol. 2018 ;9:837. Epub 2018 Jul 31. PMID: 30108506

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Licorice

Diseases : Lung Cancer

Pharmacological Actions : Antioxidants, Apoptotic, MicroRNA modulator, Nrf2 activation

[+]

Melatonin inhibits the progression of hepatocellular carcinoma.Sep 09, 2018

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Pubmed Data : Biomed Res Int. 2020 ;2020:1621394. Epub 2020 Nov 24. PMID: 33299858

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator

Additional Keywords : Exosomes

[+]

Melittin-induced long non-coding RNA NONHSAT105177 inhibits proliferation and migration of pancreatic ductal adenocarcinoma.Jan 19, 2018

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Pubmed Data : Cell Death Dis. 2018 09 20 ;9(10):940. Epub 2018 Sep 20. PMID: 30237397

Article Published Date : Jan 19, 2018

Study Type : In Vitro Study

Additional Links

Substances : Bee Venom

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , MicroRNA modulator

Additional Keywords : Exosomes

[+]

Mi-RNA-888-5p is involved in S-adenosylmethionine antitumor effects in laryngeal squamous cancer cells.Dec 06, 2020

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Pubmed Data : J Nutr. 2010 Sep ;140(9):1552-6. Epub 2010 Jul 7. PMID: 20610637

Article Published Date : Aug 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lactoferrin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, MicroRNA modulator

[+]

MiR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells.Mar 05, 2021

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Pubmed Data : Biochem Biophys Res Commun. 2019 Jan 1 ;508(1):97-101. Epub 2018 Nov 22. PMID: 30471854

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Atherosclerosis, Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, MicroRNA modulator

[+]

Novel regulation of miR-34a-5p and HOTAIR by the combination of berberine and gefitinib leading to inhibition of EMT in human lung cancer.Apr 04, 2020

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Pubmed Data : J Cell Mol Med. 2020 Apr 5. Epub 2020 Apr 5. PMID: 32248643

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Pubmed Data : Drug Des Devel Ther. 2021 ;15:245-257. Epub 2021 Jan 22. PMID: 33519190

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Paeoniflorin

Diseases : Breast Cancer

Pharmacological Actions : Chemosensitizer, MicroRNA modulator

Additional Keywords : Synergy with Tamoxifen

[+]

Paeonol attenuated inflammatory response of endothelial cells via stimulating monocytes-derived exosomal microRNA-223.Dec 31, 2017

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Pubmed Data : Front Pharmacol. 2018 ;9:1105. Epub 2018 Nov 20. PMID: 30515094

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, MicroRNA modulator

Additional Keywords : Exosomes

[+]

Click here to read the entire abstract

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Pubmed Data : Phytother Res. 2015 Mar ;29(3):415-22. Epub 2015 Jan 8. PMID: 25572695

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Pomegranate Peel, Pomegranate Polyphenols

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , apoptosis, MicroRNA modulator, Tumor Suppressor Protein p53 Upregulation

[+]

Polyphenols in the Mediterranean diet: from dietary sources to microRNA modulation.Feb 22, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Feb 23 ;10(2). Epub 2021 Feb 23. PMID: 33672251

Article Published Date : Feb 22, 2021

Study Type : Review

Additional Links

Substances : Apigenin, Ellagic Acid, Hesperidin, Kaempferol, Naringenin , Oleuropein, Polyphenols

Diseases : Cancers: All

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Chemotherapeutic, MicroRNA modulator

[+]

Propolis extract regulate microRNA expression in glioblastoma and brain cancer stem cells.May 02, 2021

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Pubmed Data : Anticancer Agents Med Chem. 2021 May 3. Epub 2021 May 3. PMID: 33949939

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Pubmed Data : Oncol Res. 2018 Feb 8. Epub 2018 Feb 8. PMID: 29422113

Article Published Date : Feb 07, 2018

Study Type : In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, MicroRNA modulator, NF-kappaB Inhibitor

[+]

Puerarin inhibits the progression of bladder cancer.Oct 04, 2020

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Pubmed Data : Cancer Biother Radiopharm. 2020 Oct 5. Epub 2020 Oct 5. PMID: 33016781

Article Published Date : Oct 04, 2020

Study Type : In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Bladder Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator

[+]

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Pubmed Data : Molecules. 2019 Dec 23 ;25(1). Epub 2019 Dec 23. PMID: 31878082

Resveratrol induces apoptosis in a time and dose dependent manner in CCRF-CEM cells. Dec 31, 2014

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Pubmed Data : Biochem Biophys Res Commun. 2018 Apr 11. Epub 2018 Apr 11. PMID: 29654764

Article Published Date : Apr 10, 2018

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Fibrosis

Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator

[+]

Rosmarinic acid might potentially be a therapeutic agent for suppressing the Warburg effect in gastric carcinoma.Dec 31, 2014

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Pubmed Data : Drug Des Devel Ther. 2015 ;9:2695-703. Epub 2015 May 19. PMID: 26056431

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Rosemaric Acid

Diseases : Gastric Cancer, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, MicroRNA modulator

Additional Keywords : Warburg Effect

[+]

S-Adenosylmethionine regulates apoptosis and autophagy in MCF-7 breast cancer cells.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2015 Dec ;18(12):1209-14. PMID: 26877850

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Pubmed Data : Inflammation. 2019 Aug ;42(4):1265-1275. PMID: 30847744

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

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Substances : Sinomenine

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, MicroRNA modulator

[+]

Sinomenine inhibits lipopolysaccharide-induced inflammatory injury.Apr 30, 2018

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Pubmed Data : Biomed Pharmacother. 2018 May ;101:422-429. Epub 2018 Mar 22. PMID: 29501764

Article Published Date : Apr 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Sinomenine

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Sinomenine inhibits migration and invasion of human lung cancer cell.Apr 26, 2020

Sulforaphane inhibited cancer stemness through miR-200c induction, which resulted in the inhibition of the self-renewal, metastasis, and tumor initiation.Feb 11, 2016

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Pubmed Data : J Formos Med Assoc. 2016 Feb 12. Epub 2016 Feb 12. PMID: 26879838

Article Published Date : Feb 11, 2016

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Oral Cancer

Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Chemopreventive, MicroRNA modulator

Additional Keywords : Cancer Stem Cells

[+]

Sulforaphane inhibits the activation of hepatic stellate cell by miRNA-423-5p targeting suppressor of fused.Sep 30, 2019

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Pubmed Data : Hum Cell. 2019 Oct ;32(4):403-410. Epub 2019 Jul 5. PMID: 31278688

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator

[+]

Sulforaphane, quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras.Sep 30, 2014

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Pubmed Data : Biochimie. 2019 May 9. Epub 2019 May 9. PMID: 31078586

Article Published Date : May 08, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Chemosensitizer, MicroRNA modulator

Additional Keywords : Cancer Stem Cells

[+]

Tanshinone IIA could represent a promising candidate for heart failure therapy.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2016 ;8(7):3124-32. Epub 2016 Jul 15. PMID: 27508033

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Heart Failure

Pharmacological Actions : Cardioprotective, MicroRNA modulator

[+]

Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox-LDL-challenged human monocyte-derived macrophages.Sep 11, 2019

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Pubmed Data : J Cell Biochem. 2019 Sep 12. Epub 2019 Sep 12. PMID: 31512787

Article Published Date : Sep 11, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator

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Astragaloside IV protects guman cardiomyocytes from hypoxia/reoxygenation injury by regulating miR-101a May 10, 2020

Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells.Sep 30, 2018

Astragaloside significantly inhibited colorectal cancer cell migration and invasion by inducing miR-134 expression.Oct 16, 2017

Astragaloside Ⅳ can improve the function of human EPC secretory exosomes.Dec 19, 2020

Attenuating role of withaferin A in the proliferation and migration of lung cancer cells.Feb 28, 2021

Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A.Nov 30, 2013

Baicalein induces apoptosis of pancreatic cancer cells. Dec 31, 2020

Baicalein modulates the radiosensitivity of cervical cancer cells in vitro.Jun 10, 2021

Benzyl isothiocyanate promotes miR-99a expression through ERK/AP-1-dependent pathway in bladder cancer cells.Oct 05, 2019

Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells.May 31, 2019

Berberine attenuates Aβ-induced neuronal damage through regulating miR-188/NOS1 in Alzheimer's disease,Oct 31, 2020

Berberine encapsulated PEG-coated liposomes attenuate Wnt1/β-catenin signaling in rheumatoid arthritis via miR-23a activation.Feb 13, 2020

Berberine induces apoptosis in non-small-cell lung cancer cells by upregulating miR-19a targeting tissue factor.Dec 31, 2018

Berberine inhibited metastasis through miR-145/MMP16 axis in vitro.Jan 05, 2021

Berberine inhibits adipocyte differentiation, proliferation and adiposity through down-regulating galectin-3.Sep 15, 2019

Berberine is a promising natural drug that has a potential therapeutic effect on neurodegenerative diseases.Oct 30, 2019

Berberine may be a novel agent to enhance chemotherapeutic responses in cisplatin-resistant gastric cancer patients.May 02, 2016

Berberine might be a potential preventive biofactor for human breast cancer metastasis by targeting chemokine receptor genes.Jan 31, 2016

Berberine modulates ASK1 signaling mediated through TLR4/TRAF2 via upregulation of miR-23a.Sep 17, 2018

Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia.Feb 12, 2020

Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability.Mar 31, 2018

Berberine sensitizes human hepatoma cells to regorafenib.Dec 31, 2020

Berberine suppressed MCF-7 and MDA-MB-231 breast cancer cells by upregulating miR-214-3p.Dec 31, 2019

Berberine treatment suppresses the replication of Respiratory syncytial virus (RSV).May 01, 2015

Beta-elemene reverses chemoresistance of breast cancer via regulating MDR-related microRNA expression.Dec 31, 2013

Beta-phenethyl isothiocyanate promotes neurite growth in primary sensory neurons.Dec 31, 2018

Bioactive compounds of Rheum ribes L. and its anticancerogenic effect via induction of apoptosis and miR-200 family expression in human colorectal cancer cells.Jul 20, 2020

Blueberry inhibits invasion and angiogenesis in chemically induced oral squamous cell carcinogenesis.Jun 18, 2016

Blueberry phenolics reduce gastrointestinal infection of patients with cerebral venous thrombosis.Dec 31, 2016

Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs.Nov 30, 2020

Bufalin inhibits cell proliferation and induces mitochondria-dependent apoptosis in osteosarcoma cells.Dec 31, 2015

Bufalin inhibits cellular proliferation and cancer stem cell-like phenotypes via upregulation of MiR-203 in glioma.Nov 22, 2017

Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b.Aug 31, 2019

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.Mar 06, 2017

Cafestol may be a novel agent for bone diseases.Jun 30, 2015

Calcitriol potentiates the anti-HCV effect of miR-130a in both Con1b replicon and J6/JFH1 culture systems.Dec 31, 2014

Camel milk could protect against or decrease the deleterious effects of many environmental toxicants and carcinogens such as PAHs.Dec 31, 2011

Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells.Dec 27, 2018

Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression.Jan 23, 2017

Cardioprotective effect of paeonol against epirubicin-induced heart injury.Apr 24, 2018

Carnosic acid might be a prospective therapeutic drug for liver fibrosis.Dec 31, 2016

Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells.Apr 30, 2018

Celastrol inhibits growth and metastasis of human gastric cancer cell MKN45 by down-regulating microRNA-21.May 31, 2019

Celastrol may inhibit colon cancer cell proliferation by negatively regulating miR-21 and the PI3K/AKT/GSK-3β pathway.Dec 31, 2018

Cell cycle regulation by berberine in human melanoma A375 cells.Jul 31, 2020

Chemicals from the diet can influence the expression of functionally important long noncoding RNAs.Jan 11, 2017

Chlorogenic acid can regulate theapoptosis of non-small lung cancer through Notch pathway.Aug 19, 2017

Citrus aurantium dry extracts ameliorate adipocyte differentiation of 3T3-L1 cells exposed to TNFα by down-regulating miR-155 expression. May 27, 2020

Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells.Apr 23, 2019

Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration.Jul 19, 2017

Combined curcumin and temozolomide treatment significantly inhibited U 87 MG cell proliferation and induced apoptotic death, compared with each alone.Jul 16, 2015

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression.Nov 05, 2018

Cowpea is a promising anti-inflammatory dietary component by down regulation of proinflammatory cytokines.Oct 09, 2014

Cucurbitacin B exerts significant anti-cancer activity by regulating expression of XIST via miR-29b.Dec 31, 2020

Curcumin as a MicroRNA Regulator in Cancer: A Review.Jul 22, 2016

Curcumin could increase the expression of hsa-miR-138, hsa-miR-138 inhibited cell proliferation and invasive ability.Dec 31, 2014

Curcumin decreases miR-21 levels through both increasing miR-21 exosome exclusion from the cells and inhibiting the transcription of the miR-21 gene.Nov 30, 2015

Curcumin induces p16 and its downstream target miR-146b-5p and suppresses IL-6.Aug 16, 2015

Curcumin inhibited cell proliferation and induced apoptosis of human non-small cell lung cancer cells.Sep 07, 2015

Curcumin inhibited oral squamous cell carcinoma cells proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling.Oct 29, 2014

Curcumin inhibits cancer progression through regulating expression of microRNAs.Jan 31, 2017

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells.Nov 17, 2014

Curcumin inhibits the proliferation, migration, invasion, and apoptosis of diffuse large B-cell lymphoma cell line.Dec 31, 2019

Curcumin intake affects miRNA signature in murine melanoma.Dec 31, 2012

Curcumin modulates chronic myelogenous leukemia exosomes compositionMar 29, 2016

Curcumin modulates miR-19/PTEN/AKT/p53 axis to exhibit its protective effects against BPA-associated breast cancer promotion.Sep 30, 2014

Curcumin prevented human autocrine growth hormone signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated EMT in T47D breast cancer cells.Nov 22, 2018

Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases.May 29, 2016

Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer.Jan 09, 2020

Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

Curcumol inhibits the viability and invasion of colorectal cancer cells via miR-30a-5p and Hippo signaling pathway.Mar 31, 2021

Cyanidin-3-glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway.Dec 31, 2018

View the Evidence:
663 Abstracts with MicroRNA modulator Research