Photoprotective

Name	AC	CK
Astaxanthin	8	28
Vitamin C	7	16
Cocoa	3	13
Carotenoids	3	12
Ferulic acid	2	12
Flavonoids	9	12
Lactobacillus plantarum	2	12
Pomegranate	2	12
Quercetin	2	11
Rosemary	2	11
Apple Polyphenols	1	10
Frankincense	1	10
Fucoidan	4	10
Fucoxanthin	4	10
Grapefruit	1	10
Hesperidin	2	10
Lactobacillus paracasei	1	10
Peppermint	1	10
Phloretin	1	10
Piperine	2	10
Polyphenols	5	10
Aloe Vera	4	8
Seaweed	3	8
Chrysanthemum Indicum	2	7
Ginsenosides	6	7
Green Tea	3	7
Lotus	5	6
Vitamin D	4	6
Carvacrol	1	5
Coconut	1	5
Curcuminoids	1	5
Fennel	1	5
Honeydew (melon)	1	5
Lemon Balm	1	5
Silymarin	1	5
Strawberry	1	5
Turmeric	1	5
White Tea	1	5
Apigenin	3	4
Bee Propolis	3	4
Hawthorn	2	4
Melatonin	3	4
Patchouli	2	4
Perilla	2	4
Spirulina	2	4
Achiote	2	3
Coenzyme Q10	2	3
Lutein	3	3
Naringenin	2	3
Prunella vulgaris	2	3
Rutin	2	3
Silibinin	2	3
Tomato	2	3
Zeaxanthin	3	3
Anthocyanins	2	2
Antrodia Camphorate	1	2
Apple	1	2
Astragaloside	2	2
Bifidobacterium Breve	1	2
Bilberry	1	2
Blackberry	1	2
Caffeic Acid	1	2
Cannabidiol	2	2
Chaga Mushroom (Inonotus obliquus)	1	2
Citrus naringin	2	2
Corn Silk	1	2
Cysteine (see N-Acetylcysteine)	1	2
Ellagic Acid	1	2
Fermented Foods and Beverages	1	2
Flaxseed	1	2
Galactooligosaccharides	1	2
Garlic	1	2
Ginseng (American)	1	2
Ginseng (Korean)	1	2
Glutathione	1	2
Grape	1	2
Honeysuckle	1	2
Hydrangea	1	2
Kaempferia parviflora	1	2
Lycopene	1	2
Moringa oleifera	2	2
Nexrutine (Phellodendrom)	1	2
Orange: Mandarin	1	2
Paeonol	1	2
Peach	1	2
Piceatannol	2	2
Polypodium leucotomos	1	2
Prickly Pear Cactus	1	2
Propolis: Brazillian	2	2
Pumpkin Seeds	1	2
Royal Jelly	1	2
Sesamin	1	2
Sesamol	1	2
Vitamin E	2	2
Walnut	2	2
Zerumbone	2	2
6-Shogaol	1	1
Acai	1	1
Arctigenin	1	1
Baicalein	1	1
Black Currant	1	1
Black Tea	1	1
Blue Honeysuckle	1	1
Burdock	1	1
Caffeic acid phenethyl ester	1	1
Caffeine	1	1
Chrysanthemum Morifolium	1	1
Cinnamaldehyde	1	1
Coconut oil: topical	1	1
Cordyceps sinensis	1	1
Crowberry	1	1
Cyanidin	1	1
Cyanidin 3-glucoside	1	1
Elderberry	1	1
Eriodictyol	1	1
Ginger	1	1
Grape Seed Extract	1	1
Hibiscus	1	1
Holy Basil	1	1
Hops	1	1
Hydroxytyrosol	1	1
Jujube	1	1
Krameria lappacea: topical	1	1
Kudzu	1	1
Lactobacillus fermentum	1	1
Licorice	1	1
Luteolin	1	1
Lychee	1	1
Medicinal Mushrooms	1	1
Myricetin	1	1
Nicotinamide	1	1
Nuts: All	1	1
Okra	1	1
Oleuropein	1	1
Olive	1	1
Olive leaf extract	1	1
Olive oil: topical	1	1
Paeoniflorin	1	1
Panax Notoginseng	1	1
Passion Flower	1	1
Passion fruit	1	1
Peanut oil: topical	1	1
Pterostilbene	1	1
Puerarin	1	1
Pycnogenol (Pine Bark)	1	1
Reishi Mushroom	1	1
Resveratrol	1	1
Rose Hips	1	1
Rosemaric Acid	1	1
Sage	1	1
Seaweed: Brown	1	1
Sesame oil: topical	1	1
Terminalia chebula	1	1
Tetrahydrocurcumin	1	1
Tocopherols	1	1
Violaxanthin	1	1

[+]

A combination of rosemary and grapefruit polyphenols have photoprotective and anti-ageing effects. Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Photochem Photobiol. 2021 Dec 12. Epub 2021 Dec 12. PMID: 34897721

Article Published Date : Dec 11, 2021

Study Type : Human In Vitro

Additional Links

Substances : Phlorotannins, Seaweed: Brown

Diseases : Aging Skin, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Photoprotective

[+]

Bellis perennis extract mitigates UVA-induced keratinocyte damage.Jul 31, 2021

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Pubmed Data : J Photochem Photobiol B. 2021 Aug ;221:112247. Epub 2021 Jun 19. PMID: 34175580

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Mar 31 ;10(4). Epub 2018 Mar 31. PMID: 29614719

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Pubmed Data : J Dermatolog Treat. 2019 Mar 21:1-9. Epub 2019 Mar 21. PMID: 30897007

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1032-1040. PMID: 28183235

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Photoprotective

Additional Keywords : Plant Extracts

[+]

Caffeic acid prevents UVB radiation induced photocarcinogenesis.Jul 31, 2018

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Pubmed Data : Toxicol Appl Pharmacol. 2018 Aug 1 ;352:87-96. Epub 2018 May 23. PMID: 29802912

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Caffeic Acid

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Anticarcinogenic Agents, Photoprotective

[+]

Chrysanthemum indicum was a novel photo-protective agent from natural resources against UV irradiation.Sep 30, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Rejuvenation Res. 2015 Oct ;18(5):437-48. Epub 2015 Aug 20. PMID: 25849065

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Substances : Chrysanthemum Indicum

Diseases : Aging Skin, Oxidative Stress, Ultraviolet Radiation Induced Damage

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Photoprotective

Additional Keywords : Plant Extracts

[+]

Cold-pressed perilla oil has therapeutic potential in terms of protecting against skin photo-aging.Feb 21, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : PeerJ. 2019 ;6:e6218. Epub 2019 Jan 9. PMID: 30643686

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Photoprotective

[+]

Dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

In vitro and in vivo photoprotective effects of (-)-Loliode isolated from the brown seaweed, Sargassum horneri.Nov 15, 2021

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Pubmed Data : Photodermatol Photoimmunol Photomed. 2018 Jan ;34(1):82-90. Epub 2017 Oct 9. PMID: 28857273

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Nexrutine (Phellodendrom)

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Anti-Inflammatory Agents, Photoprotective

[+]

Oral administration of black ginger extract significantly prevents UVB-induced photoaging in hairless mice.Sep 30, 2014

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Pubmed Data : Photodermatol Photoimmunol Photomed. 2014 Oct ;30(5):237-45. Epub 2014 Jan 9. PMID: 24313661

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Pubmed Data : Phytother Res. 2018 Sep ;32(9):1741-1749. Epub 2018 May 10. PMID: 29748977

Sesamin has potential for use as a skin protection agent in antiphotodamage and skin care products.Sep 11, 2019

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Pubmed Data : Free Radic Biol Med. 2015 Dec ;89:690-700. Epub 2015 Nov 4. PMID: 26456052

Article Published Date : Nov 30, 2015

Study Type : Animal Study, Transgenic Animal Study

Additional Links

Substances : Achiote

Diseases : Skin Cancer: Prevention, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemopreventive, Nrf2 activation, Photoprotective

Additional Keywords : Nutritional Sunscreen, Plant Extracts

[+]

The dietary ingestion of Aloe sterols protected against chronic UVB damage in mouse skin.Dec 19, 2016

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Pubmed Data : Photodermatol Photoimmunol Photomed. 2016 Dec 20. Epub 2016 Dec 20. PMID: 27995657

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Pubmed Data : Photochem Photobiol Sci. 2020 May 20. Epub 2020 May 20. PMID: 32432303

Article Published Date : May 19, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Polypodium leucotomos

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Photoprotective, Tumor Suppressor Protein p53 Upregulation

[+]

The study delineated the efficacy of chaga polysaccharides in mitigating UV-induced DNA damage in zebrafish.Jan 31, 2021

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Pubmed Data : Heliyon. 2021 Feb ;7(2):e06003. Epub 2021 Feb 4. PMID: 33598573

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Pubmed Data : Chem Biol Interact. 2018 Feb 25 ;282:63-68. Epub 2018 Jan 6. PMID: 29317250

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Pubmed Data : Mar Drugs. 2020 Jul 25 ;18(8). Epub 2020 Jul 25. PMID: 32722441

Article Published Date : Jul 24, 2020

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Blue Light Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Photoprotective

Anti Therapeutic Actions : Blue Light (400−495 nm)

[+]

Astaxanthin has distinct biological effects to prevent the photo-aging of the skin.Oct 18, 2018

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Pubmed Data : Photochem Photobiol. 2018 Oct 19. Epub 2018 Oct 19. PMID: 30338860

Article Published Date : Oct 18, 2018

Study Type : Review

Additional Links

Substances : Astaxanthin

Diseases : Aging Skin, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Photoprotective

[+]

Astragalin attenuates UVB radiation-induced actinic keratosis formation. Dec 31, 2017

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Pubmed Data : Anticancer Agents Med Chem. 2018 ;18(7):1001-1008. PMID: 29298652

Article Published Date : Dec 31, 2017

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Pubmed Data : Biomol Ther (Seoul). 2016 Nov 1 ;24(6):616-622. PMID: 27257012

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Pubmed Data : Int J Biol Macromol. 2020 Oct 31. Epub 2020 Oct 31. PMID: 33144254

Article Published Date : Oct 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Photoprotective

[+]

Galangin shields human keratinocytes from ultraviolet B-induced oxidative stress.Feb 28, 2015

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Pubmed Data : Biomol Ther (Seoul). 2015 Mar ;23(2):165-73. Epub 2015 Mar 1. PMID: 25767685

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Photooxidative Stress, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Photoprotective

[+]

Ganoderma polysaccharides treatment may serve as a novel strategy for antiphotoaging.Dec 31, 2016

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Pubmed Data : Mol Med Rep. 2017 Jan ;15(1):111-116. Epub 2016 Dec 12. PMID: 27959406

Herbs provide protection against harmful UV radiation due to their antioxidant activity.Jul 01, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Rev. 2011 Jul ;5(10):164-73. PMID: 22279374

Article Published Date : Jul 01, 2011

Study Type : Review

Additional Links

Substances : Coconut oil: topical, Flavonoids, Krameria lappacea: topical, Olive oil: topical, Peanut oil: topical, Sesame oil: topical, Vitamin C, Vitamin E

Diseases : Skin Diseases: Photo-Aging, Sunburn, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Antioxidants, Photoprotective

[+]

Hydroxytyrosol might be proposed as an encouraging candidate for the prevention of blue light-induced premature photoaging.May 31, 2019

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Pubmed Data : J Cell Physiol. 2019 Jun ;234(6):9065-9076. Epub 2018 Oct 26. PMID: 30367495

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Pubmed Data : Photochem Photobiol. 2019 Jan 12. Epub 2019 Jan 12. PMID: 30636010

Article Published Date : Jan 11, 2019

Study Type : In Vitro Study

Additional Links

Substances : Apigenin, Flavonoids, Naringenin

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Genoprotective, Photoprotective

[+]

piceatannol and passion fruit seed extract containing high amounts of piceatannol are potential anti-photoageing cosmetic ingredients.Dec 31, 2012

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The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers.Dec 31, 2019

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Pubmed Data : Adv Exp Med Biol. 2020 ;1268:257-283. PMID: 32918223

Article Published Date : Dec 31, 2019

Study Type : Review

Additional Links

Substances : Vitamin D

Diseases : Skin Cancer

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Chemopreventive, Photoprotective

[+]

These findings imply that ginsenoside Rg3 stereoselectively demonstrates skin anti-photoaging activities.Dec 31, 2013

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Pubmed Data : Biol Pharm Bull. 2014 ;37(10):1583-90. Epub 2014 Jul 24. PMID: 25056231

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Aging Skin, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Photoprotective

[+]

These results demonstrate that walnuts can protect human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis.Dec 31, 2013

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Pubmed Data : Skin Pharmacol Physiol. 2014 ;27(3):132-40. Epub 2014 Jan 11. PMID: 24434642

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View the Evidence: 221 Abstracts with Photoprotective Research

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A combination of rosemary and grapefruit polyphenols have photoprotective and anti-ageing effects. Dec 31, 2015

Astaxanthin seems protective against UV-induced skin deterioration and helps maintain healthy skin in healthy people.Jun 24, 2018

Continuous administration of apple polyphenol for 12 weeks alleviated ultraviolet irradiation induced skin pigmentation.Apr 12, 2020

Cutaneous photoprotective activity of a short-term ingestion of high flavanol cocoa.Jan 19, 2019

Daily oral pomegranate consumption may lead to enhanced protection from ultraviolet photodamage.Oct 09, 2019

Daily supplementation with carotenoids protects human skin against both UVB-induced erythema and UVA-induced pigmentation.Feb 17, 2020

Evaluation of the effectiveness and safety of peppermint peel soft peeling for skin ageing.Oct 31, 2019

L. paracasei KW3110 suppressed blue light-induced retinal pigment epithelial cell death.Aug 08, 2018

Long-term prophylactic astaxanthin supplementation may inhibit age-related skin deterioration.Jun 30, 2017

Protective effects of a topical antioxidant mixture against ultraviolet-induced photodamage in human skin.Nov 30, 2008

Quercetin is able to reduce redness, itching, and inflammation of damaged skin; it may also help restore skin barrier function.Dec 31, 2015

These findings are preliminary confirmation of the anti-aging benefit to the skin of L. plantarum HY7714 as a nutricosmetic agent.Dec 27, 2015

Topical application of boswellic acids may represent a suitable treatment option for selected features of skin photoaging.Dec 31, 2009

A phlorotanin, 6,6'-bieckol from Ecklonia cava, against photoaging by inhibiting MMP-1, -3 and -9 expression on UVB-induced HaCaT keratinocytes.Dec 11, 2021

Bellis perennis extract mitigates UVA-induced keratinocyte damage.Jul 31, 2021

Carvacrol mediates its protective effect through modulation of UVB-induced ROS.Oct 31, 2015

Cultured coconut extract showed a barrier-enhancing effect and anti-inflammatory properties against UVB irradiation-induced inflammation.Jul 31, 2017

Fennel is a potential botanical agent for the treatment of skin damage induced by UV irradiation.Nov 14, 2016

Fucoxanthin exerted a protective effect against UV irradiation.Aug 31, 2016

Hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis.Jan 14, 2016

Hesperidin treatment effectively protected HaCaT keratinocytes from these UVA radiation-induced skin injuries.Nov 30, 2016

Lemon balm extract may be considered as a candidate for oral or topical photoprotective agents against UVB-induced skin damage.Aug 03, 2016

Melon concentrate administration could be a useful strategy for photoprotection due to its antioxidant properties.Mar 30, 2018

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Protective effect of a fucose-rich fucoidan isolated from Saccharina japonica against ultraviolet B-induced photodamage.Jun 14, 2020

Skin protective activity of silymarin and its flavonolignans.Mar 13, 2019

Strawberry-based formulations protect human dermal fibroblasts against UVA-induced damage.Jun 13, 2017

Topical application of green and white tea extracts provides protection from solar-simulated ultraviolet light in human skin.May 31, 2009

Turmeric extract and its curcuminoids provided significant protection against photooxidative damage and apoptosis retinal cells.Feb 28, 2017

Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoagingFeb 29, 2016

Aloe polysaccharide protects skin cells from UVB irradiation.Mar 20, 2019

An aloe vera gel powder containing aloe sterols prevents skin damage induced by UVB irradiation.Oct 11, 2016

Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo.Jun 05, 2016

Bifidobacterium breve supplementation has a photoprotective effect against skin damage induced by ultraviolet irradiation in hairless mice.Nov 30, 2012

Cacao extract may offer a protective effects against photo-aging.Feb 04, 2016

Cactus cladodes extract minimizes the effects of UV irradiation on keratinocytes and hairless mice.Nov 30, 2017

Caffeic acid prevents UVB radiation induced photocarcinogenesis.Jul 31, 2018

Chrysanthemum indicum was a novel photo-protective agent from natural resources against UV irradiation.Sep 30, 2015

Cold-pressed perilla oil has therapeutic potential in terms of protecting against skin photo-aging.Feb 21, 2020

Combination of Bifidobacterium longum and galacto-oligosaccharide protects the skin from photoaging.May 31, 2021

CoQ10 reduces corneal damages after UVB exposure in vivo and in vitro by preserving mitochondrial function.Oct 08, 2014

Didymin improves UV irradiation resistance in C. elegans.Dec 31, 2018

Dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA.Dec 31, 2016

Dietary immature Citrus unshiu alleviates UVB- induced photoaging.May 31, 2020

Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice.Sep 30, 2013

Effects of topical application of patchouli alcohol on the UV-induced skin photoaging in mice.Oct 14, 2014

Ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation.Jul 31, 2010

Ergostatrien-3β-ol has significant beneficial antiinflammatory and antiphotoaging activities.Sep 09, 2016

Fermented blackberry by Lactobacillus plantarum can be a potential candidate for protecting skin aging against UV irradiation.Oct 10, 2019

Ferulic acid has potential against UVB-induced carcinogenesis in the swiss albino mice.Jul 31, 2015

Formulations containing naringenin may be a promising approach to protecting the skin from the deleterious effects of UVB irradiation.Dec 31, 2015

Fucoxanthin could be a novel adjuvant for preventing exacerbations associated with skin inflammation as well as protecting skin against UV radiation.Oct 09, 2018

Garlic may be effective for preventing skin photoaging accelerated by UV irradiation through the antioxidative system and MMP regulation.Dec 31, 2015

Grape stem extract reduces UVB-induced oxidative damage and hence can play a protective role in skin photo-damage.Jul 31, 2017

Hawthorn polyphenol extract inhibits UVB-induced skin photoaging.Aug 14, 2018

Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth.Jan 25, 2017

Hydrangea serrata extract attenuate UVB-induced photoaging. Feb 28, 2019

In vitro and in vivo photoprotective effects of (-)-Loliode isolated from the brown seaweed, Sargassum horneri.Nov 15, 2021

Korean red ginseng is an excellent skin whitening and anti-aging product.Apr 30, 2020

Long-term intake of the lotus seed tea showed the effect of preventing loss of skin moisture, mitigating the formation of abnormal keratinocytes.Aug 31, 2015

Low molecular-weight fucoidan can be used as a skin-protective remedy for photoaging.Aug 17, 2018

Luteolin prevents UVB-induced skin photoaging damage.Dec 31, 2020

Mekabu fucoidan is an effective suppressor of inflammation in an ultraviolet B-irradiated mouse model.Sep 30, 2015

N-acetylcysteine protects against chorioretinal damage induced by photodynamic therapy. Apr 17, 2018

Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina.Dec 31, 2016

Nexrutine inhibits the ultraviolet B induced cutaneous inflammatory responses in SKH-1 mouse skin.Dec 31, 2017

Oral administration of black ginger extract significantly prevents UVB-induced photoaging in hairless mice.Sep 30, 2014

Oral Aloe vera gel powder has the ability to prevent the skin photoaging.Apr 03, 2016

Oral supplementation of L-glutathione prevents UVB-induced melanogenesis and oxidative stress.Jun 25, 2019

Paeonol a promising botanical in protecting skin from UVB-induced photoaging.Aug 31, 2018

Patchouli oil was capable of maintaining skin structural integrity caused by UV irradiation and it was useful in preventing photoaging.Jun 10, 2014

Photoprotective

View the Evidence:
221 Abstracts with Photoprotective Research